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Littérature scientifique sur le sujet « Site-Specific Targeting »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "Site-Specific Targeting"

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Nuno-Gonzalez, Patricia, Hsu Chao, and Kazuhiro Oka. "Targeting site-specific chromosome integration." Acta Biochimica Polonica 52, no. 2 (2005): 285–91. http://dx.doi.org/10.18388/abp.2005_3441.

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The concept of gene therapy was introduced with great promise and high expectations. However, what appeared simple in theory has not translated into practice. Despite some success in clinical trials, the research community is still facing an old problem: namely, the need for a vector that can deliver a gene to target cells without adverse events while maintaining a long-term therapeutic effect. Some of these challenges are being addressed by the development of hybrid vectors which meld two different viral systems to incorporate efficient gene delivery and large cloning capacity with site-speci

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Horn, C., and A. M. Handler. "Site-specific genomic targeting in Drosophila." Proceedings of the National Academy of Sciences 102, no. 35 (2005): 12483–88. http://dx.doi.org/10.1073/pnas.0504305102.

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Fruitwala, Mushtaq A., and N. M. Sanghavi. "Site-Specific Drug Targeting with Fluorouracil Microspheres." Drug Delivery 3, no. 1 (1996): 5–8. http://dx.doi.org/10.3109/10717549609031375.

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García-Otín, Angel-Luis. "Mammalian genome targeting using site-specific recombinases." Frontiers in Bioscience 11, no. 1 (2006): 1108. http://dx.doi.org/10.2741/1867.

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Tomlinson, E. "Site-Specific Drug Carriers." Engineering in Medicine 15, no. 4 (1986): 197–202. http://dx.doi.org/10.1243/emed_jour_1986_015_053_02.

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Site-specific drug carriers are required to exclusively deliver drug molecules to difficult targets within the body. They should do so in a form which protects the drug and host from one another. This contribution reviews the reasons for drug targeting, and describes some of the features required of two types of carrier system, i.e., particulates and soluble (bio)conjugates.

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D'Souza, Martin J., and Patrick DeSouza. "Site specific microencapsulated drug targeting strategies- liver and gastro-intestinal tract targeting." Advanced Drug Delivery Reviews 17, no. 3 (1995): 247–54. http://dx.doi.org/10.1016/0169-409x(95)00058-f.

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Mason, Rosemarie, Cameron Adams, Carole Bewley, John Mascola, and Mario Roederer. "Potent SIV-specific Antibodies Targeting the Cyanovirin Binding Site." AIDS Research and Human Retroviruses 30, S1 (2014): A211—A212. http://dx.doi.org/10.1089/aid.2014.5457c.abstract.

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Gorman, Cori, and Clayton Bullock. "Site-specific gene targeting for gene expression in eukaryotes." Current Opinion in Biotechnology 11, no. 5 (2000): 455–60. http://dx.doi.org/10.1016/s0958-1669(00)00127-0.

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Lovering, Richard M., Camilo Vanegas, Stephen J. P. Pratt, Su Xu, and Jason Hammond. "Site-specific Targeting Platelet-rich Plasma Via Superparamagnetic Nanoparticles." Medicine & Science in Sports & Exercise 46 (May 2014): 357. http://dx.doi.org/10.1249/01.mss.0000494250.63191.70.

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Bodor, N. "Drag targeting by site-specific chemical drug delivery systems." European Journal of Pharmacology 183, no. 1 (1990): 119–20. http://dx.doi.org/10.1016/0014-2999(90)91385-o.

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Thèses sur le sujet "Site-Specific Targeting"

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Redhead, Helen Margaret. "Drug loading of biodegradable nanoparticles for site specific drug delivery." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338495.

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Smith, Lacie Marie. "Synthesis of site specific DNA methylating compounds targeting pancreatic ß-cells." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-3/smithl/laciesmith.pdf.

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Liu, Daniel S. (Daniel Shao-Chen). "Extending the utility of enzymes for site-specific targeting of fluorescent probes." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/87470.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, February 2014.<br>Cataloged from PDF version of thesis. "February 2014."<br>Includes bibliographical references.<br>Genetically encodable fluorescence reporters such as the green fluorescent protein (GFP) are useful for studying protein expression, localization, and dynamics in a variety of biological systems. GFP and its related variants, however, suffer from several drawbacks. Compared to chemical fluorophores, they are large, dim, and limited in other reporting capabilities. Super-bright chemical fluorophores su

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Uttamapinant, Chayasith. "Cellular delivery and site-specific targeting of organic fluorophores for super-resolution imaging in living cells." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/79263.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Recent advances in super-resolution fluorescence microscopy have pushed the spatial resolution of biological imaging down to a few nanometers. The key element to the development of such imaging modality is synthetic organic fluorophores with suitable brightness and photostability. However, organic fluorophores are very difficult to use in live cells because of their chemical compositions. Many excellent fluorophores, such as

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Di, Domenico Alexandra Isabelle. "Characterisation of transgene expression in human embryonic stem cells by combining gene targeting and site-specific recombination." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/24524.

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Predictable levels of transgene expression will be essential for full exploitation of human ES cells (hES) in basic research and medicine. In practice however, transgene expression in mammalian cells is often found to be silenced, low or variegated presenting a serious drawback in this area of research. Unpredictability of transgene expression arises mostly as a consequence of variable transgene copy number and/or inhibitory effects of surrounding chromatin structures in which the transgene has randomly integrated. We have addressed this issue in hES cells, by combining gene targeting and site

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Barattin, Michela. "Development of nanocarriers with responsive interfacial properties for site-specific drug delivery." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424682.

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The functional and morphological alterations of the vascular endothelium of the lymphatic system, the micro-environmental alterations such as the amplification of the enzyme kit, the overexpression of specific receptors, the increase in the redox potential, temperature and the lowering of the pH, are typical characteristics of tumor tissues. These features can be exploited successfully for the development of suitable supramolecular and colloidal systems with passivelly and activelly guided delivery of anticancer drugs at the site of action. Here we aimed at investigating a novel pH responsive

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Tennant, Peter Andrew. "Genome editing using site-specific nucleases : targeting highly expressed genomic regions for robust transgene expression and genetic analysis." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22857.

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Integration and expression of exogenous genetic material – in particular, transgenes – into the genomes of model organisms, cell lines or patients is widely used for the creation of genetically modified experimental systems and gene therapy. However, loss of transgene expression due to silencing is still a major hurdle which remains to be overcome. Judicious selection of integration loci can help alleviate the risk of silencing; in recent years the ability to efficiently and specifically target transgene integration has been improved by the advent of site-specific nucleases (SSNs). SSNs can be

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Grabentin, Christoph [Verfasser], and Rolf [Akademischer Betreuer] Schubert. "Development and in vitro as well as in vivo characterization of perfluorocarbon nanoemulsions for passive or site-specific targeting applications in 19F magnetic resonance imaging / Christoph Grapentin ; Betreuer: Rolf Schubert." Freiburg : Albert-Ludwigs-Universität Freiburg, 2016. http://d-nb.info/1126920436/34.

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Khamassi, Marwa. "Conception de nouveaux vaccins anti-VIH basés sur des épitopes conformationels cross clade de gp41 issus d'anticorps muqueux protecteurs de sujets exposés au VIH mais restant séronégatifs (ESN) By shaping the antigen-binding site in IgA, the CH1α domain is crucial for HIV-1 protection in highly exposed sero-negative individuals IgA targeting human immunodeficiency virus-1 envelope gp41 triggers antibody-dependent cellular cytotoxicity cross-clade and cooperates with gp41-specific IgG to increase cell Lysis". Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB036.

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Le SIDA est une infection transmise essentiellement au niveau des muqueuses génitales. Pour empêcher la transmission du virus de l'immunodéficience humaine (VIH-1), il faudrait dresser des barrières efficaces susceptibles de bloquer l'infection dès l'entrée du VIH-1 dans les muqueuses, avant l'établissement de réservoirs muqueux. Les IgA sont les principaux effecteurs immunitaires protecteurs des muqueuses génitales et participent à la protection contre la transmission muqueuse du virus. En effet, chez des femmes hautement exposées au VIH-1 qui restent séronégatives malgré des rapports sexuels

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Livres sur le sujet "Site-Specific Targeting"

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Cellesi, Francesco, Martin Ehrbar, and Filippo Rossi, eds. Nanosized Drug Delivery Systems: Colloids and Gels for Site Specific Targeting. Frontiers Media SA, 2020. http://dx.doi.org/10.3389/978-2-88966-022-3.

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Yamamoto, Takashi. Targeted Genome Editing Using Site-Specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System. Springer, 2016.

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Yamamoto, Takashi. Targeted Genome Editing Using Site-Specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System. Springer, 2015.

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Yamamoto, Takashi. Targeted Genome Editing Using Site-Specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System. Springer, 2015.

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Yamamoto, Takashi. Targeted Genome Editing Using Site-Specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System. Springer Japan, 2015.

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Joyner, Alexandra, ed. Gene Targeting. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637928.001.0001.

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Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications. As with the previous edition Gene Targeting: A Practical Approach 2e concentrates on gene targeting in mouse ES cells, but the techniques described can be easily adapted to applications in tissue culture including those for human cells. The first

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Chapitres de livres sur le sujet "Site-Specific Targeting"

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Patel, Vivek, Ajay J. Khopade, and Jayvadan K. Patel. "Subcellular Targeting of Nanoparticles for Cancer Theranostics." In Site-specific Cancer Nanotheranostics. CRC Press, 2023. http://dx.doi.org/10.1201/9781003368731-18.

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Ofosu-Boateng, Malvin, Seth Kwabena Amponsah, and Benedicta Obenewaa Dankyi. "Antibody-Based Targeting of Nanoplatforms for Cancer Theranostics." In Site-specific Cancer Nanotheranostics. CRC Press, 2023. http://dx.doi.org/10.1201/9781003368731-16.

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Amoafo, Emmanuel Boadi, Malvin Ofosu-Boateng, Kwasi Agyei Bugyei, and Seth Kwabena Amponsah. "Carbohydrate-Based Targeting of Nanoplatforms for Cancer Theranostics." In Site-specific Cancer Nanotheranostics. CRC Press, 2023. http://dx.doi.org/10.1201/9781003368731-17.

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Adeyemi, Samson A., Philemon N. Ubanako, Pavan Walvekar, and Yahya E. Choonara. "Peptide-Based Targeting of Nanoplatforms for Cancer Theranostics." In Site-specific Cancer Nanotheranostics. CRC Press, 2023. http://dx.doi.org/10.1201/9781003368731-15.

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Tiwari, Gaurav, Ancha Kishore Babu, Charul Khatri, and Namdev L. Dhas. "Aptamer-Based Targeting of Nanoplatforms for Cancer Theranostics." In Site-specific Cancer Nanotheranostics. CRC Press, 2023. http://dx.doi.org/10.1201/9781003368731-14.

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Runge, C. Ford. "Land Targeting and Agricultural Policy." In Site-Specific Management for Agricultural Systems. American Society of Agronomy, Crop Science Society of America, Soil Science Society of America, 2015. http://dx.doi.org/10.2134/1995.site-specificmanagement.c58.

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Davis, S. S., and L. Illum. "Particulate Systems for Site Specific Drug Delivery." In Targeting of Drugs 4. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4899-1207-7_17.

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Tomlinson, E. "Biological Dispersion and the Design of Site-Specific Protein Therapeutic Systems." In Targeting of Drugs 2. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-9001-5_1.

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Zorro Shahidian, Lara, and Sylvain Daujat. "Development and Validation of Antibodies Targeting Site-Specific Histone Methylation." In Histone Methyltransferases. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2481-4_9.

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Bouma, J., J. Verhagen, J. Brouwer, and J. M. Powell. "Using systems approaches for targeting site-specific management on field level." In Applications of Systems Approaches at the Field Level. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-017-0754-1_2.

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Actes de conférences sur le sujet "Site-Specific Targeting"

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Jarausch, Konrad, John F. Richards, Lloyd Denney, Alex Guichard, and Phillip E. Russell. "Site Specific 2-D Implant Profiling Using FIB Assisted SCM." In ISTFA 2002. ASM International, 2002. http://dx.doi.org/10.31399/asm.cp.istfa2002p0467.

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Abstract Advances in semiconductor technology are driving the need for new metrology and failure analysis techniques. Failures due to missing, or misregistered implants are particularly difficult to resolve. Two-dimensional implant profiling techniques such as scanning capacitance microscopy (SCM) rely on polish preparation, which makes reliably targeting sub 0.25 um structures nearly impossible.[1] Focused ion beam (FIB) machining is routinely used to prepare site-specific cross-sections for electron microscopy inspection; however, FIB induced artifacts such as surface amorphization and Ga io

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Ma, Lixin, Miao Zhang, and Ping Yu. "Imaging site-specific peptide-targeting in tumor tissues using spectral-domain optical coherence tomography." In SPIE BiOS, edited by Anita Mahadevan-Jansen, Tuan Vo-Dinh, and Warren S. Grundfest. SPIE, 2011. http://dx.doi.org/10.1117/12.874079.

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Bansal, Nidhi, Joanna Wexler, Yeon-jin Kwon, et al. "Abstract 1989: Targeting Sin3-Pf1 complex: Novel site-specific epigenetic therapy for triple negative breast cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1989.

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Mazzucchelli, Serena, Miriam Colombo, Elisabetta Galbiati, et al. "O6-alkylguanine-DNA transferase (SNAP) as capture module for site-specific covalent bioconjugation of targeting protein on nanoparticles." In SPIE BiOS, edited by Wolfgang J. Parak, Marek Osinski, and Kenji Yamamoto. SPIE, 2013. http://dx.doi.org/10.1117/12.2001648.

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Gupta, Dr Madhu, Dr Vikas Sharma, Prof G. P. Agrawal, and Prof S. P. Vyas. "Abstract A31: Cyclic NGR peptide functionalized PEG-PLGA nanoparticles as dual-targeting carrier for site specific antitumor drug delivery." In Abstracts: AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.brain15-a31.

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Kwon, Woo Jun, Jisu Ryu, Christopher H. Kang, Michael B. Schmidt, and Nicholas Croy. "Automated Sample Depth Targeting with Low kV Cleaning by Focused Ion Beam Microscopy for Atom Probe Tomography." In ISTFA 2020. ASM International, 2020. http://dx.doi.org/10.31399/asm.cp.istfa2020p0299.

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Abstract Focused ion beam (FIB) microscopy is an essential technique for the site-specific sample preparation of atom probe tomography (APT). The site specific APT and automated APT sample preparation by FIB have allowed increased APT sample volume. In the workflow of APT sampling, it is very critical to control depth of the sample where exact region of interest (ROI) for accurate APT analysis. Very precise depth control is required at low kV cleaning process in order to remove the damaged layer by previous high kV FIB process steps. We found low kV cleaning process with 5 kV and followed by 2

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Rudra-Ganguly, Nandini, Pia M. Challita-Eid, Christine Lowe, et al. "Abstract 574: AGS62P1, a novel site-specific antibody drug conjugate targeting FLT3 exhibits potent anti-tumor activity regardless of FLT3 kinase activation status." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-574.

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Lueshen, Eric, Indu Venugopal, and Andreas Linninger. "Intrathecal Magnetic Drug Targeting: A New Approach to Treating Diseases of the Central Nervous System." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93117.

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Intrathecal (IT) drug delivery is a standard technique which involves direct injection of drugs into the cerebrospinal fluid (CSF)-filled space within the spinal canal to treat many diseases of the central nervous system. Currently, in order to reach the therapeutic drug concentration at certain locations within the spinal canal, high drug doses are used. With no method to deliver the large drug doses locally, current IT drug delivery treatments are hindered with wide drug distributions throughout the central nervous system (CNS) which cause harmful side effects. In order to overcome the curre

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Humphreys, Robin C., Jessica Kirtely, Amha Hewit, et al. "Abstract 639: Site specific conjugation of ARX-788, an antibody drug conjugate (ADC) targeting HER2, generates a potent and stable targeted therapeutic for multiple cancers." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-639.

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Chen, Xiaoming, Garrett W. Astary, Thomas H. Mareci, and Malisa Sarntinoranont. "In Vivo Contrast-Enhanced MR Imaging for Direct Infusion Into Rat Peripheral Nerve." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192919.

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Direct infusion of therapeutic agents into the spinal cord provides a promising way to treat traumatic injury and intrinsic diseases of the spinal cord, which may cause paralysis and other neurological deficits. Direct infusion into the spinal cord involves complex invasive surgery since the spinal cord is well protected by the vertebral bone. Instead, infusion directly into peripheral nerves is of interest since it provides a remote delivery site to the spinal cord, requiring less invasive surgery and reducing the risk of spinal cord injury during surgery. It may also allow targeting of speci

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Rapports d'organisations sur le sujet "Site-Specific Targeting"

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Hodges, Thomas K., and David Gidoni. Regulated Expression of Yeast FLP Recombinase in Plant Cells. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7574341.bard.

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Research activities in both our laboratories were directed toward development of control of the FLP/frt recombination system for plants. As described in the text of the research proposal, the US lab has been engaged in developing regulatory strategies such as tissue-specific promoters and the steroid-inducible activation of the FLP enzyme while the main research activities in Israel have been directed toward the development and testing of a copper-regulated expression of flp recombinase in tobacco (this is an example of a promoter activation by metal ions). The Israeli lab hat additionally com

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Barash, Itamar, J. Mina Bissell, Alexander Faerman, and Moshe Shani. Modification of Milk Composition via Transgenesis: The Role of the Extracellular Matrix in Regulating Transgene Expression. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570558.bard.

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Altering milk composition via transgenesis depends on three main factors. (1) The availability of an efficient regulatory sequences for targeting transgene(s) to the mammary gland; (2) a reliable in vitro model to test the expression of transgenes prior to their introduction to the animal genome; and (3) better understanding of the major factors which determine the rate of gene expression and protein synthesis. The current studies provide the necessary means and knowledge to alter milk protein composition via transgenesis. The following specific goals were achieved: a: Identifying regulatory r

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Burns, Malcom, and Gavin Nixon. Literature review on analytical methods for the detection of precision bred products. Food Standards Agency, 2023. http://dx.doi.org/10.46756/sci.fsa.ney927.

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The Genetic Technology (Precision Breeding) Act (England) aims to develop a science-based process for the regulation and authorisation of precision bred organisms (PBOs). PBOs are created by genetic technologies but exhibit changes which could have occurred through traditional processes. This current review, commissioned by the Food Standards Agency (FSA), aims to clarify existing terminologies, explore viable methods for the detection, identification, and quantification of products of precision breeding techniques, address and identify potential solutions to the analytical challenges presente

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