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Littérature scientifique sur le sujet « Skin recurrences »

Auteur : Grafiati

Publié le 14 mars 2023

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Articles de revues sur le sujet "Skin recurrences"

Gage, I., S. J. Schnitt, A. Recht, A. Abner, S. Come, L. N. Shulman, J. M. Monson, B. Silver, J. R. Harris et J. L. Connolly. « Skin recurrences after breast-conserving therapy for early-stage breast cancer. » Journal of Clinical Oncology 16, n^o 2 (février 1998) : 480–86. http://dx.doi.org/10.1200/jco.1998.16.2.480.

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PURPOSE To assess the frequency and prognosis of skin recurrences after breast-conserving therapy (BCT) compared with other breast recurrences. MATERIALS AND METHODS From 1968 to 1986, 1,624 patients with unilateral stage I or II breast cancer treated with BCT at the Joint Center for Radiation Therapy (Boston, MA) underwent gross tumor excision and received a dose of > or = 60 Gy to the tumor bed. Skin recurrences (SR) were defined as breast recurrences without associated parenchymal disease. An invasive breast recurrence with any parenchymal disease noted clinically or radiographically was scored as an other breast recurrence (OBR). Median follow-up for survivors was 137 months. RESULTS SR represented 8% (18 of 229) of all breast recurrences and occurred in 1.1% of all patients. The outcome after local recurrence was different for patients with SR and invasive OBR. Patients with SR more frequently had uncontrolled local failure (50%; 9 of 18) than did patients with OBR (14%; 26 of 188) (P = .0007). Forty-four percent (8 of 18) of patients with SR had distant metastasis simultaneously or within 2 months of the recurrence compared with 5% (9 of 188) of invasive OBR patients (P < .0001). For patients without distant metastasis at the time of recurrence, the 5-year actuarial rate of development of distant metastasis was 60% for SR patients compared with 39% for invasive OBR patients (P = .07), and the corresponding 5-year actuarial survival rates beyond the time of local failure were 51% and 79%, respectively (P = .06). CONCLUSION In contrast to other types of invasive breast recurrence after breast-conserving therapy, skin recurrences are rare and are associated with a significantly higher rate of distant metastasis and uncontrolled local disease as well as a lower rate of survival.

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Rahimian, Joseph, Raymond Khan et Keith A. LaScalea. « Does Nasal Colonization or Mupirocin Treatment Affect Recurrence of Methicillin-Resistant Staphylococcus aureus Skin and Skin Structure Infections ? » Infection Control & ; Hospital Epidemiology 28, n^o 12 (novembre 2007) : 1415–16. http://dx.doi.org/10.1086/523273.

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Some patients with community-associated methicillin-resistant Staphylococcus aureus skin and skin structure infections have experienced frequent recurrences. We performed a retrospective study and determined that the presence of nasal colonization did not affect recurrence and nasal mupirocin treatment marginally decreased recurrence

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Long, Tyler, Austin Dunn, Mary Arndt et Eric Parlette. « Melanoma Recurrence after Mohs Micrographic Surgery with MART-1 : A Systematic Review and Meta-analysis ». SKIN The Journal of Cutaneous Medicine 5, n^o 6 (5 novembre 2021) : 579–89. http://dx.doi.org/10.25251/skin.5.6.2.

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Background: Surveys suggest wide-spread use of MART-1 in MMS for CM among Mohs surgeons, but no previous systematic review has investigated the efficacy of this specific procedure. Methods: A systematic search and meta-analysis of retrospective studies on MMS with MART-1 was performed from Pubmed, Medline, and Cochrane databases for articles published from their inception to October 30, 2020. We performed a chi-squared analysis of homogenized data to examine the relationship between recurrence location and rate of recurrence. A risk of bias was obtained with the ROBINS-I tool. [PROSPERO ID: CRD42020221826] Results: Among the included studies, there were a total of 15 (0.52%) local recurrences of melanoma in-situ and invasive melanoma after MMS with MART-1. Conclusions: This review has served to demonstrate that MMS with MART-1 immunostaining in frozen sections is a technique that produces satisfactory recurrence rates for melanoma in-situ and invasive melanoma.

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Tonev, Ivan Dimitrov, Yana Stoeva Pirgova et Nikolay Vladimirov Conev. « Primary Adenoid Cystic Carcinoma of the Skin with Multiple Local Recurrences ». Case Reports in Oncology 8, n^o 2 (3 juin 2015) : 251–55. http://dx.doi.org/10.1159/000431082.

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Primary adenoid cystic carcinoma (PACC) of the skin is a rare tumor with fewer than 70 cases studied in detail in the English literature. This type of tumor shows a prolonged course and a growth pattern usually manifested by multiple local recurrences and has a low potential for distant metastases. The most important modality for primary treatment is surgical resection followed by radiotherapy. We report a woman aged 43 years at the time of diagnosis, who presented with a slow-growing nodule in the right axilla without lymph node enlargement. A wide local excision was performed, and the histology revealed an adenoid cystic carcinoma. During the next 24 years, another four local recurrences were excised (the last one in 2015) and confirmed histologically to be adenoid cystic carcinoma. The patient was given 44 Gy of radiotherapy after the second surgery in 1996. PACC of the skin is a rare tumor with insufficient data concerning the efficacy of the surgical technique and chemotherapy and radiotherapy treatment, even more so in the case of multiple recurrences. After the last recurrence, the patient was offered an active follow-up based on the long tumor-free intervals in the past and because the site of the primary tumor allowed further surgical excisions in future recurrences.

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Berlière, M., F. P. Duhoux, L. Taburiaux, V. Lacroix, C. Galant, I. Leconte, L. Fellah et al. « The Place of Extensive Surgery in Locoregional Recurrence and Limited Metastatic Disease of Breast Cancer : Preliminary Results ». BioMed Research International 2015 (2015) : 1–7. http://dx.doi.org/10.1155/2015/782654.

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The aims of this study were first to clearly define two different entities: locoregional recurrences and limited metastatic disease and secondly to evaluate the place of extensive surgery in these two types of recurrence.Material and Methods. Twenty-four patients were followed from June 2004 until May 2014. All patients underwent surgery but for 1 patient this surgery was stopped because the tumour was unresectable.Results. The median interval between surgery for the primary tumour and the locoregional recurrence or metastatic evolution was 129 months. Eight patients had pure nodal recurrences, 4 had nodal and muscular recurrences, 5 had muscular + skin recurrences, and 8 had metastatic evolution. Currently, all patients are still alive but 2 have liver metastases. Disease free survival was measured at 2 years and extrapolated at 5 years and was 92% at these two time points. No difference was observed for young or older women; limited metastatic evolution and locoregional recurrence exhibited the same disease free survival.Conclusion. Extensive surgery has a place in locoregional and limited metastatic breast cancer recurrences but this option must absolutely be integrated in the multidisciplinary strategy of therapeutic options and needs to be planned with a curative intent.

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Yevcheva, A. F., et S. M. Pukhlik. « CLINICAL SIGNS AND TREATMENT MANAGEMENT IN MALIGNANT PROCESSES OF THE SKIN OF THE EXTERNAL NOSE ». Odes’kij medičnij žurnal (The Odessa Medical Journal), n^o 6 (2022) : 43–48. http://dx.doi.org/10.54229/2226-2008-2021-6-8.

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Diagnosis and treatment of malignant neoplasms of the head and neck is an urgent modern problem of oncology, as there is a steady increasing of this pathology. At the same time are untimely diagnosis and frequent recurrences take place. The purpose is to test the method of excision of the tumor of the skin of the external nose and assess its feasibility in radical surgical removal by using anemic Klein solution. Material and methods of research: 64 patients were examined with skin neoplasms that received surgical treatment options using Klein’s anematize solution at the ENT department from 2015 to 2020 years. Patients ranged in age from 28 to 65 years, 15 women and 49 men. Patients are divided into two groups depending on the morphology of the tumor. The first group — 50 (78.2%) patients with malignant skin lesions. From this sample, 17 (34%) with basal cell carcinoma of the nasal skin and 33 (66%) with squamous cell carcinoma (G1) of the nasal skin. The second group consists of 14 (21.8%) patients with melanoma of the skin of the nose and torso. Metastasis in the deep jugular chain were diagnosed in 6 (16.7%) patients from the group of patients with melanoma. Results of the study and discussion: observations of patients for 5 years showed a satisfactory quality of life of all patients with malignant skin tumors. No recurrence of nasal cancer in the first group was registered during the follow-up of patients. Among a group of patients with melanoma, 1 (7.1%) patient was diagnosed with recurrence in the visual organ and brain. Conclusions: 1. Clinically, skin cancer was non-aggressive, had a relatively slow growth and 100% of patients had no recurrence of cancer after surgery for 5 years (p<0.05). 2. Melanoma of the skin was aggressive in a year — 1 (7.1%) patient was diagnosed recurrence in the visual organ and brain. 3. The use of Klein’s solution 5 minutes before the surgery under the base of the tumor provided a pronounced hemostasis due to vasospasm and contributed to the prevention of intraoperative recurrence in 63 (98.4%) patients (p<0.05). Key words: malignant tumors, skin of the external nose, surgical treatment, recurrences.

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Ganusevich, O. N., T. N. Nesterovich, I. V. Fedorkevich et A. S. Yakovenko. « Treatment of Locoregional Recurrences of Skin Melanoma (a Clinical Case) ». Kuban Scientific Medical Bulletin 27, n^o 3 (18 juin 2020) : 105–12. http://dx.doi.org/10.25207/1608-6228-2020-27-3-105-112.

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Aim. To demonstrate an interesting clinical case of treating a patient with intradermal melanoma metastases.Materials and methods. A patient with intradermal melanoma metastases was given a combined treatment including photodynamic therapy (PDT) and immunotherapy (intradermal administration of an immunological preparation into metastatic foci).Results. A clinical case of a patient with a locoregional recurrence of skin melanoma (SM) of the left lower leg was described. Given the prevalence of the pathological substrate and the presence of concomitant pathologies, two treatment methods were selected – PDT and intradermal administration of interferon into metastatic foci. These methods provided both the local and systemic effect. As a result, the stabilisation of the tumour process was achieved.Conclusion. Combined treatment of locoregional recurrences of skin melanoma using PDT and intrametastatic injections of immunopreparations can be used as an alternative to surgical intervention in somatically weakened patients with a large area of intradermal metastases, which will allow the tumour process to be stabilised. In cases where the area of locoregional intradermal recurrences in somatically compensated patients does not permit surgical treatment, the proposed technique may be the only possible treatment method.

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Sequeira, Andrew Jose, et MARIO Jose SEQUEIRA. « Long Term Follow Up of Cutaneous Sinus Histiocytosis (Rosai-Dorfman Disease) ». SKIN The Journal of Cutaneous Medicine 3, n^o 5 (13 septembre 2019) : 350–52. http://dx.doi.org/10.25251/skin.3.5.11.

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Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology with cutaneous variants clinically presenting with painless cervical lympadenopathy, fever, leukocytosis and other systemic findings.1 Although the skin is the most common extranodal site, rare purely cutaneous forms of the disease exist and diagnosing such case rests solely on histopathologic findings.2 We report a case with a fifteen year follow up period of this uncommon disorder and describe itsclinical course marked by multiple episodic recurrences.

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Chung, Sun M., Sandra J. Shin, Xia Chen et Paul Peter Rosen. « Recurrent Breast Carcinoma Arising in a Transverse Rectus Abdominis Myocutaneous Flap ». Archives of Pathology & ; Laboratory Medicine 128, n^o 10 (1 octobre 2004) : 1157–60. http://dx.doi.org/10.5858/2004-128-1157-rbcaia.

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Abstract Reconstruction after mastectomy for breast carcinoma with implants or myocutaneous flaps is a widely used surgical technique. Recurrence of breast carcinoma after these procedures is uncommon. Most recurrences occur in the skin or scar site of the mastectomy and are readily detectable by physical examination. There are rare reported cases of recurrent carcinoma occurring within the flaps that are usually diagnosed with the aid of imaging and subsequent pathologic examination. In most cases, these recurrences represent invasive or in situ ductal carcinoma. We report an additional 2 cases of breast carcinoma recurring within the myocutaneous flap, both of which exhibited uncommon histologic features not previously reported.

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Alarcon-Rozas, A. E., M. R. Cueva, J. Galarreta, J. Torres, E. Gonzales et J. Ramirez. « Features of recurrence of triple-negative (TN), non-metastatic breast cancer (NMBC) patients : A single institution study. » Journal of Clinical Oncology 29, n^o 27_suppl (20 septembre 2011) : 180. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.180.

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180 Background: The TN BC is the most agressive subtype. Previous studies suggested that DFS of women with TN-BC is shorter than any other subtype and they demonstrated racial differences. The behaviour of these tumours are characterised by poor prognosis affecting mostly African American young obese women. Our goal is to determine the incidence of TN in non metastatic (NM) BC, the recurrence rate (RR), the patterns of recurrence by anatomic region and the DFS. Methods: We reviewed the medical records of patients with BC diagnosed between Jan/2000 to Dec/2005 at Almenara Hospital in Lima, Peru. There were a total of 1042 patients with BC; of them 215 were identified as TN NM BC according to IHC ER, PR, and Her2/neu negatives. We collected the clinical data including age, menopausal status, staging, hormone receptor status as well as Her2/neu status. The data were analized by statistic software SPSS v. 17.0. Results: The incidence of TN NM BC were 20.6% (215); of them 18.6% (40) patients had recurrences. The median age of recurrence were 52.5 years (31-93); the median DFS were 27 months, with a median follow-up of 64 months. According to inicial staging the recurrences were 7.5% (3); 32.5% (13); and 60% (24) respectively for patients with stages I, II and III. Almost one third (35%) of patients with recurrences were lymphatic node negative at diagnosis after mastectomy. The most frequent involved organs were visceral (lung=12, liver=3) 37.5% (15); bone 25% (10); skin 20% (8); CNS 12.5% (5) and contralateral breast 5% (2). There were four nuliparus women two of them had skin recurrence and the others two had bone metastasis. Conclusions: TN NM BC constitutes 20.6% of all BC in our institution; the majority of relapses were stage III (60%). The median DFS for recurrence were 27 months and the most frequent sites involved were visceral (37%) and bone (25%). 12.5% of recurrences were to CNS and one third of the patients were lymph node negatives. This is to our knowledge the first study of patterns of recurrence in TN nonmetastatic BC in a Latino population. The incidence of TN-BC which is close to African-American population (25%).

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Thèses sur le sujet "Skin recurrences"

Mandelli, Andrea Paola. « Unfolding the immune response against Staphylococcus aureus-mediated systemic sequelae of skin recurrences ». Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1203731.

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Staphylococcal protein A (SpA) is a surface-associated virulence factor of Staphylococcus aureus (S. aureus) which binds human immunoglobulins via both Fc and Fab fragment masking the pathogen to the host immune system. This activity interacts with the normal maturation of the host immune system during an infection and allows S. aureus to cause recurrent infections as, for example, skin recurrences. Skin recurrences are not only bothersome superficial infections that require continuous treatments, but may also evolve in more complicated and systemic complications. Immunization with SpA protects animals against S. aureus systemic infections unmasking the pathogen to the host immune system, which turns out to recognize bacterial antigens otherwise hidden by SpA activity. The aim of this project was to assess the protective effect of SpAmut against skin recurrences and systemic complications in a mouse model of Skin and Soft Tissues Infections (SSTIs) set up in C57BL/6 mice, which are naturally susceptible to re-infections with S. aureus. Vaccination with SpAmut adjuvanted with AS01 (SpAmut/AS01) was able to limit bacterial spreading from the skin through the blood, abrogating S. aureus infiltration to the kidneys (target for systemic disease). S. aureus-specific protein microarrays were used to compare sera of mice vaccinated with SpAmut/AS01 and then infected with those of mice only infected for their ability to recognize a selection of S. aureus antigens. Vaccination with SpAmut/AS01 was able to unmask several S. aureus antigens to the immune system during SSTIs in mice. Interestingly, mice infected with S. aureus did not develop measurable antibodies against the mutated version of SpA, whereas infection in vaccinated mice significantly increased the avidity of antibodies against SpAmut induced by previous immunization. Furthermore, only sera from vaccinated and infected mice allowed internalization of S. aureus by human phagocytes in vitro, suggesting a functional role in mediating the in vivo observed protection. Overall, these data support the essential role of vaccination with SpA, an immunomodulator antigen of S. aureus, in the induction of a functional specific antibody response during recurrences, contributing to the control of systemic bacterial dissemination, one of the main complications developed during S. aureus-mediated SSTIs.

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Pinto, Ana Filipa Santos. « Short term morbidity and ipsilateral breast tumor recurrence associated to nipple/skin sparing mastectomy with immediate reconstruction ». Master's thesis, 2019. https://hdl.handle.net/10216/120810.

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Pinto, Ana Filipa Santos. « Short term morbidity and ipsilateral breast tumor recurrence associated to nipple/skin sparing mastectomy with immediate reconstruction ». Dissertação, 2019. https://hdl.handle.net/10216/120810.

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Eder, Simone Gabriele [Verfasser]. « 3D-histology and malignant soft tissue sarcomas of the skin : local recurrence rate and growth pattern / vorgelegt von Simone Gabriele Eder ». 2007. http://d-nb.info/983727740/34.

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Livres sur le sujet "Skin recurrences"

Sybert, Virginia. Genetic Skin Disorders. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780195397666.001.0001.

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This lavishly-illustrated resource represents a comprehensive survey of well over 300 distinct inherited dermatologic conditions. Each disease entry follows a consistent format, containing sections devoted to dermatologic features, associated clinical abnormalities, histopathology, biochemical and molecular information, treatment, mode of inheritance and recurrence risk, prenatal diagnosis, and information on differential diagnosis. Any clinician faced with a patient in whom the possibility for a genetic disorder of the skin exists will find this book a practical tool of immense interest.

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A case of sarcoma of the arm involving the skin : Amputation, recurrence in the stump a year later. [S.l : s.n., 1986.

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Chapitres de livres sur le sujet "Skin recurrences"

Jacopo, Andreuccetti, Di Leo Alberto et Enrico Lauro. « Endoscopic Subcutaneous Onlay Laparoscopic Approach ». Dans Mastering Endo-Laparoscopic and Thoracoscopic Surgery, 475–78. Singapore : Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-3755-2_66.

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AbstractIn recent years, abdominal wall surgery has shown a clear interest in reproducing traditional open techniques and avoiding intraperitoneal mesh placement. The endoscopic Subcutaneous Onlay Laparoscopic Approach (SCOLA) is very popular in South American countries, especially for small umbilical and epigastric hernias with concomitant rectus muscles diastasis. In these cases, a full midline reconstruction should be scheduled, because hernia repair alone is affected by a higher recurrences rate compared to simultaneous hernia and diastasis repair [1–5]. Through an endoscopic dissection of the preaponeurotic subcutaneous space is possible to reconstruct the abdominal wall by placing an onlay prosthesis in those patients without excess skin or subcutaneous tissue. Although SCOLA repair is safe and feasible to correct diastasis recti and symptomatic midline hernias with excellent cosmetic results, seroma and abdominal numbness are frequent complications.

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Notter, M., A. R. Thomsen, A. L. Grosu, K. Münch et Peter Vaupel. « Thermography-Controlled, Contact-Free wIRA-Hyperthermia Combined with Hypofractionated Radiotherapy for Large-Sized Lesions of Unresectable, Locally Recurrent Breast Cancer ». Dans Water-filtered Infrared A (wIRA) Irradiation, 83–95. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92880-3_6.

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AbstractUnresectable locally recurrent breast cancers (LRBCs) lead to life-threatening situations and a tremendous loss of quality of life. Most patients have received radiotherapy (RT) during primary treatment and re-irradiation (re-RT) using standard doses might be denied due to the risk of unacceptable cumulative toxicity. Therefore, an effective tumor control is often abandoned.Mild hyperthermia (39–43 °C), allows for significant reductions in re-RT dose and effective tumor responses with acceptable toxicity even after heavy pretreatment. More than 280 patients have been treated with superficial hyperthermia by water-filtered infrared A (wIRA-HT), which can cover even large lesions. Hyperthermia was immediately followed by hypofractionated re-RT of 5x4 Gy, once a week.Evaluating 201 patients, overall response rate was 94%. 170 patients with macroscopic LRBC were stratified into 4 size classes (rClasses), and detailed response rates are presented. Accordingly, response rates of 31 patients with microscopic disease after resection of LRBC are communicated.RT-related acute and late toxicity was limited to grades 1 and 2. Due to this low toxicity, re-recurrences after CR and new local progression after PR could be re-treated using the same treatment schedule. Real-time thermographic and visual controls have allowed to almost exclude the risk of thermal skin damage.

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Tchero, Huidi. « Management of Scars in Skin of Color ». Dans Textbook on Scar Management, 371–77. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_43.

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AbstractKeloids and hypertrophic scars are abnormal scars, produced by an odd wound-healing response to trauma with a higher incidence in pigmented skin patients. They could be painful or itchy, producing functional and/or cosmetic disability. This chapter focuses on defining scars especially in pigmented skin and the different methods for treating keloids that have been investigated in the literature. Up to the present time, the ideal treatment method has not been defined, although numerous modalities have been designated. We will represent the variances among different scar types and their management methods, concentrating on their indications, modes of action, uses, safety, and efficiency of the following therapies: intralesional steroid, injections of silicone gel/sheet, radiotherapy, photodynamic therapy, electrical stimulation, surgical excision and adjuvant therapy, and cryosurgery. Combination therapies have also shown some value. Still, there is a shortage of randomized clinical trials (RCTs) evaluating such treatment modalities. Management of scar in pigmented (colored) skin is clinically challenging. Therefore, strategic assessment and targeted therapy with focus on deterring recurrence are most needed. The quality of evidence is crucial to select efficient treatments for patients with colored skin, presenting with keloid.

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Téot, Luc. « Atrophic Scars : Reinforcing the Flap Mattress Using Adipocyte Transfer in Paraplegic Patients at Risk of Pressure Ulcer Recurrence ». Dans Textbook on Scar Management, 531–33. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_63.

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AbstractAtrophic scars may be defined as depressive areas on the skin, due to a defect of fatty tissue under the skin. This situation may lead to adherence to the depth (fascia, bone, tendon) to be a source of functional impairment. Most of the atrophic scars are secondary to acne localized over the face. Multiple techniques were proposed to restore the volume and uniformize the surface, like laser, injection of fat, microneedling, microdermabrasion, dermal fillers, and surgical techniques such as subcision and platlet rich plasma (PRP). On the basis of level 1 evidence currently available, it appears that PRP can improve the quality of atrophic acne scars treated with ablative fractional CO2 laser and decrease the duration of laser-related side effects including edema and erythema (Goutos). Regenerative surgery, including fat harvesting, centrifugation, and isolation of adipocyte stem cells, has been promoted since years and should be repeated when injected fat progressive crush is observed. The clinical case presented here is a paraplegic patient presenting a pressure sore in the left ischiatic area. The flap was successful but the depth of the transplanted fatty tissue was decreasing after some years. A first fat injection was programmed.

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Liu, Wei, Xiaoli Wu, Zheng Gao et Lingling Xia. « Minimally Invasive Technologies for Treatment of HTS and Keloids : Low-Dose 5-Fluorouracil ». Dans Textbook on Scar Management, 251–62. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_30.

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AbstractBoth hypertrophic scar (HTS) and keloid are pathological scars that tend to overgrow and overproduce extracellular matrices, lead to large-sized scars along with severe pain and itching, and even result in functional disability. In particular, keloids are considered as benign skin tumors due to their nature of uncontrolled growth beyond the original wound boundary and invasion into normal skin; therefore, anticancer therapy has been employed in keloid therapy. 5-Fluorouraci (5-FU), a pyrimidine analog, is a commonly used chemotherapy agent and it has also been previously used in keloid treatment with intralesional injection at a concentration of 40–50 mg/ml. The authors propose the use of low dose 5-FU at the concentration of 1.5–5 mg/ml for establishing a sustainable chemotherapy without causing significant side effects in order to cure keloid by a possible long-term chemotherapy, which is essential for controlling keloid relapse. Since 2002, the authors have treated over 10,000 cases of keloids and demonstrated that this approach is effective and safe. In addition to intralesional injection treatment of keloids and HTS with combined use of 5-FU and steroids, it was also used for preventing keloid recurrence after surgical excision. In this chapter, the authors introduce the general background of keloid and HTS chemotherapy, the rational of using low-dose drugs, and the clinical protocol of low-dose 5-FU injection therapy and its applications along with typical case presentation.

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Zöller, N., et S. Kippenberger. « Influence of wIRA Irradiation on Wound Healing : Focus on the Dermis ». Dans Water-filtered Infrared A (wIRA) Irradiation, 195–202. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92880-3_16.

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AbstractImpaired wound healing, imbalanced fibroblast proliferation, and extracellular matrix synthesis are associated with aberrant scarring. The impact of impaired wound healing can be tremendous due to physical restrictions, high recurrence rates, stigmatization, and secondary infections in chronic wounds. It is therefore essential to develop alternative treatment regimens to those that are currently used. The highly diverse influence of water-filtered infrared-A (wIRA) on cell metabolism, bacterial colonisation, wound healing, and its high tissue penetration – reaching the subcutis without inducing harmful increases in skin surface temperature or pain – led to the investigation of the influence of the spectral and thermal component of wIRA on normal and keloid fibroblasts in vitro. Data show the potential value of the spectral and the thermal component of wIRA as an adjuvant therapy for aberrant scarring due to its differential influence on the proliferation, migration, and collagen type I synthesis of normal and keloid fibroblasts. The observed aspects in the context of hypertrophic scar treatment need to be evaluated in further basic research and clinical studies.

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Viscidi, Raphael P., Chen Sabrina Tan et Carole Fakhry. « Papillomaviruses and polyomaviruses ». Dans Oxford Textbook of Medicine, sous la direction de Christopher P. Conlon, 877–85. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0094.

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There are nearly 200 human papillomavirus types that infect epithelia of skin and mucous membranes. They infect only humans, and cause conditions including the following: skin warts and verrucas, which are caused by types 1 and 2; infection initiated when, after minor skin abrasions, for example, the basal cells of the epithelium come in contact with infectious virus; anogenital warts, which are caused by types 6 and 11; transmitted by direct sexual contact, these are the most common sexually transmitted infection; present clinically as multiple exophytic lesions or as subclinical flat lesions. They can be treated topically with podophyllin or imiquimod, or by ablative surgical methods. Recurrences are common. A highly efficacious prophylactic vaccine is available.

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Abdelsattar, Jad M., Moustafa M. El Khatib, T. K. Pandian, Samuel J. Allen et David R. Farley. « Soft Tissue ». Dans Mayo Clinic General Surgery, 207–16. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190650506.003.0015.

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The integumentary system is formed from the mesoderm. Skin and its appendages compose the largest bodily organ. The integumentary system and underlying soft tissue (fat, fascia, and muscle) protect the body from damage and infection. Skin lesions are typically asymptomatic, but they occasionally itch, bleed, or ulcerate. Work-up for diagnosis of soft tissue sarcomas includes CT, MRI, and biopsy. First-line treatment for symptomatic benign lipomas is surgical resection. Complications of surgical treatment of malignant tumors of the skin and soft tissue are postoperative bleeding, infection, hematoma, and recurrence.

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Peris, Ketty, et Maria Concetta Fargnoli. « Dermoscopy for treatment monitoring (recurrence vs. clearance) ». Dans Dermatoscopy of Non-Pigmented Skin Tumors, 123–26. CRC Press, 2016. http://dx.doi.org/10.1201/b18754-32.

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Peris, Ketty, et Maria Fargnoli. « Dermoscopy for treatment monitoring (recurrence vs. clearance) ». Dans Dermatoscopy of Non-Pigmented Skin Tumors, 123–26. CRC Press, 2015. http://dx.doi.org/10.1201/b18754-36.

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Actes de conférences sur le sujet "Skin recurrences"

Rubio, IT, M. Ramos, J. Palacin, T. Ramos, M. Iglesias, J. Gonzalez-Orus, I. Toscas et V. Marco. « Skin sparing mastectomy and immediate breast reconstruction : more indications with no increased in recurrences in breast cancer patients. » Dans CTRC-AACR San Antonio Breast Cancer Symposium : 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-4152.

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Janosky, M., S. Demaria, Y. Novik, R. Oratz, A. Tiersten, J. Goldberg, E. Wang et al. « Abstract OT2-1-02 : Novel combination of toll-like receptor (TLR)-7 agonist imiquimod and local radiotherapy in the treatment of breast cancer chest wall recurrences or skin metastases ». Dans Abstracts : Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013 ; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-ot2-1-02.

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Broekmans, A. W., F. J. M. der Meer et K. Briët. « TREATMENT OF CONGENITAL THROMBOTIC SYNDROMES ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643718.

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Hereditary antithrombin III deficiency,protein C deficiency, and protein S deficiency predispose to the occurrence of venous thrombotic disease at a relatively youngage and often without an apparent cause. These disorders inherit as an autosomal dominant trait. Heterozygotes are at risk fosuperficial thrombophlebitis, thrombosis atnearly every venous site, and pulmonary embolism. Homozygous protein C deficiency may present itself with a purpura fulminans syndrome shortly after birth.In the acute phase of venous thromboembolism heparin is effective for preventing extension of the thrombotic process, and pulmonary embolism. In patients with antithrombin III deficiency the concomittant useof antithrombin III concentrate is controversial, although some patients may requirehigher doses of heparin.Substitution therapy is only indicated in homozygous protein C deficient patientswith purpura fulminans. Fresh frozen plasma i.v. is the treatment of choice, in a dosage of 10 ml/kg once or twice daily. The current prothrombin complex concentrates may induce new skin lesions and disseminated intravascular coagulation. After the lesions have been healed(mostly in 4 to6 weeks)coumarin therapy may effectively prevent new episodes of purpura fulminans, provided the prothrombin time is kept within 2,5 - 4,0 INR. Heparin is ineffective for preventing purpura fulminans due to homozygous protein C deficiency.The thrombotic manifestations in heterozygotes are effectively prevented by coumarin therapy. This is supported by the observation that patients may remain free of thrombosis during long-term treatment and may have recurrences shortly after the withdrawal of the coumarin drug. The therapeutic range for the prothrombin time should be within 2,0 - 4,0 INR, target value 3,0 INR. In the initial phase of oral anticoagulant therapy protein C deficient patients are prone to the development of coumarin induced hemorrhagic skin (tissue) necrosis.In the patients studied in Leiden, it occurred in about 3% of the treated patients. Heparin appears to be ineffective for the prevention of coumarin-induced skin necrosis; high loading doses of coumarin should be avoided and the prothrombin timeshouldbe checked dialy during the initial phase of oral anticoagulant treatment. Tissue necrosis may contribute to bleeding complications after fibrinolytic therapy, ashas been observed in two protein C deficient patients.In clinical situations with an increased risk for thrombosis such as surgery and pregnancy, heparin (in-low-doses) alone orin combination with coumarins have been used succesfully for the prevention of thrombosis. The need for antithrombin III concentrates in patients with hereditary antithrombin III deficiency in such situations is not substantiated.Although anabolic steroids are capable to increase the plasma concentrations of antithrombin III and of protein C in the respective deficiency states, its efficacy in preventing thrombotic episodes remains to be established.An optimal strategy for preventing thrombosis in congenital thrombotic syndromes is to identify still asymptomatic patients. In case of antithrombin III, protein C, and protein S deficiency this search is feasible. During risk situations for thrombosis patients are to be protected against the development of thrombosis.In Leiden pregnant women with one of the deficiencies are treated from the 14th week of pregnancy, initially with a shortacting coumarin drug, after the 34th week withheparin s.c. b.i.d. at therapeutic dosages,and after delivery coumarin therapy is reTnstituted during 6 weeks. The use of oralcontraceptives should be avoided, unlesspatients are under coumarin treatment. As long as deficient patients remain asymptomatic no antithrombotic treatment is indicated. After the first documented thromboticincident patients are treated indefinitelywith oral anticoagulants.

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Yi, M., KK Hunt, F. Meric-Bernstam, SJ Kronowitz, KM Nayeemuddin, B. Feig, RF Hwang et al. « Local-regional and distant recurrence rates in skin-sparing mastectomies compared with non-skin-sparing mastectomies. » Dans CTRC-AACR San Antonio Breast Cancer Symposium : 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-4138.

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Frasson, Antônio Luiz, Martina Lichtenfels, Fernanda Barbosa, Alessandra Borba Souza et Carolina Malhone. « IS NIPPLE-SPARING MASTECTOMY AN OPTION FOR PATIENTS WITH IPSILATERAL BREAST CANCER RECURRENCE ? » Dans Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1074.

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Introduction: Nipple-sparing mastectomy (NSM) is a conservative mastectomy approach for breast cancer with oncological safety and good aesthetic satisfaction. The initial indications of NSM excluded patients with previous radiation, ptosis, high body mass index (BMI) and macromastia, although these contraindications have been challenged. Different authors expanded the classic indications of NSM for patients with previous breast surgery/irradiation, neoadjuvant chemotherapy, and short tumor-nipple distance and showed safety and low complication rates. However, there are few data about the suitability of performing NSM with immediate reconstruction for the treatment of recurrent disease. Objectives: The aim of this study was to analyze the complication and local recurrence rates of 24 patients with indication of mastectomy, however with no skin or nipple involvement, who opted to undergo NSMs with immediate reconstruction for the treatment of ipsilateral breast tumor recurrence (IBTR). Methods: Between January 2001 and December 2018, we evaluated 24 patients that underwent NSMs for the treatment of IBRT after a previous BCS (breast cancer surgery) followed by radiotherapy. All patients were operated by the same surgeon, the data were retrospectively evaluated by the medical chart and the patient`s follow-up was updated during the appointments. Results: The patient’s mean age in the salvage surgery was 49 years. The majority of patients (70.8%) underwent bilateral procedures, one (5.9%) patient due to the diagnosis of invasive cancer in both breasts, one (5.9%) DCIS in both breasts, and 15 (88.2%) patients without disease in the contralateral breast, most of them for prophylactic or aesthetic reasons to avoid asymmetry and to reach a better aesthetic result. Breast reconstruction was performed using silicone prosthetic implants for 22 (91.7%) patients and with tissue expander for only two (8.3%) patients. Patients were followed for a mean time of 132 months since the first surgery. In the mean follow-up of 40 months after the NSM surgery, five (20.8%) patients were diagnosed with local recurrence and only one patient died from the progression of the disease. Patients presented 4.8% of partial and 2.4% of total nipple necrosis. No infection and no implant loss was observed. Conclusions: In the long-term follow-up since the first surgery, we observed low complication rates and a good survival rate, although associated with high local recurrence in patients diagnosed with IBTR undergoing NSM as salvage surgery. We demonstrated that NSM may be considered after IBTR for patients with indication of mastectomy, with no skin or NAC (nipple-areola complex) involvement, who did not want to undergo total mastectomy with resection of the skin and NAC.

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Winkler, S., R. L. Prosst, T. Haase, Flechtenmacher Chr, J. Stern et J. Gahlen. « First experimental experience in adjuvant intraoperative photodynamic therapy (AIOPDT) in S117 sarcoma in mice ». Dans European Conference on Biomedical Optics. Washington, D.C. : Optica Publishing Group, 2001. http://dx.doi.org/10.1364/ecbo.2001.4433_140.

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The effectiveness of photodynamic therapy (PDT) as an adjuvant treatment for diverse malignant tumors has been investigated in numerous studies. The therapeutic success and extent of side effects of PDT is mainly determined by the applied photosensitizer (PS) and laser energy. Adjuvant intraoperative photodynamic therapy (AIOPDT) using the PS mTHPC (meso-Tetrahydroxyphenylchlorin) causes selective tumor cell death when combined with laser irradiation of a PS specific wavelength (652 nm). Our study proved AIOPDT as an efficient modality to significantly increase postoperative recurrence-free survival after R1/R2 resection of a subcutaneously implanted soft tissue sarcoma in mice. We used mTHPC in a dose of (0,3 mg/kg BW) and a laser light energy of 5 Joule (irradiation time: 50 seconds). First results showed an increase of postoperative recurrence-free survival (Median: 103 days) in 5 animals treated with AIOPDT compared to a control group of 7 animals (Median: 20 days). The tissue specific accumulation of mTHPC was determined by point spectrofluorometry and showed a 2.28 higher PS-accumulation in the tumor center, tumor bed (1.5) and overlying skin (3.8) compared to muscle tissue (1.0) as reference parameter. Our first experimental data recommend AIOPDT to be an efficient adjuvant method to prolonge recurrence-free survival after tumor resection.

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Fuyuan Liao et Yih-Kuen Jan. « Using recurrence network approach to quantify nonlinear dynamics of skin blood flow in response to loading pressure ». Dans 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2012. http://dx.doi.org/10.1109/embc.2012.6346892.

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Cruz, Marcelo Ribeiro da Luz, Valéria Fernandes Roppa Cruz, Marcelle Gomes Pinheiro Maia Lessa, Ana Cláudia de Oliveira Mazoni et Claudinei Dextro. « BREAST LIPOSARCOMA ». Dans XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1013.

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Breast sarcomas are a heterogenous group of malignancies that originate from the breast support stroma. They represent less than 0.1% of all breast neoplasms and less than 5% of all sarcomas. They are more frequent in women and between the fourth and sixth decades. Previous breast cancer treatment and radiotherapy are the main risk factors. The usual clinical presentation is a breast mass, which grows progressively and can reach a large size. They rarely attach themselves to the thorax or infiltrate the skin. Skin changes, when occur, are usually secondary to a large distitute. The tumor is usually well or partially defined, with a firm consistency. Lymph nodes are palpable in up to 25% of cases but tend to be reactional. Imaging findings are nonspecific. For histopathological diagnosis, it is necessary to exclude metaplastic carcinoma, and immunohistochemistry is useful to detect evidence of epithelial origin. Treatment requires resection with wide margins, and mastectomy may be necessary. Hematogenous dissemination occurs, and lymph node interventions should only be performed in the presence of a proven histopathological impairment. There is a trend of improvement in survival with radiotherapy after conservative surgery. After mastectomy, radiotherapy may be beneficial in cases of increased risk of local recurrence (lesions larger than 50 mm, unsuitable margins, and higher grade variants). The role of chemotherapy remains controversial. Liposarcoma, a histological subtype of sarcoma, despite being the second most frequent subtype in soft tissues, rarely occurs in the breast. Liposarcoma encompasses a spectrum, from lesions with essentially benign behavior to frankly malign lesions. Liposarcomas classified as myxoid, pleomorphic, and dedifferentiated have a higher risk of recurrence and metastases. The main differential diagnoses of breast liposarcoma include other breast tumors with lipomatous or liposarcomatous components, fat necrosis, and metaplastic carcinoma. CSSP, 48 years old, female, attended the Mastology Service of the Central Hospital of the Army, referring a breast nodule for 2 months with growth in the period. On clinical examination, a well-defined, mobile oval nodule with firm consistency was observed, measuring 40 mm, with no associated findings. At mammography and ultrasonography, the nodule was oval and circumscribed. Magnetic resonance imaging showed heterogeneous enhancement and a type II curve. A simple mastectomy was performed due to the poor tumor-breast relationship, with a histopathological result of dedifferentiated liposarcoma with areas of myxoid pattern, measuring 40 mm, and free histopathological margins. Adjuvant radiotherapy was indicated due to the diagnosis of dedifferentiated liposarcoma with areas of myxoid pattern.

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Nissen, Leonardo Paese, Iris Rabinovich, João Pedro Cruz Lima Chagas, Jacqueline Justino Nabhen et Isadora Machado Agresta. « ONCOLOGICAL OUTCOME IN PATIENTS SUBMITTED TO NIPPLE-AREOLA COMPLEX SPARING MASTECTOMY AFTER NEODADJUVANT CHEMOTHERAPY ». Dans XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1061.

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Introduction: Breast cancer is the most frequent cancer among women in Brazil and worldwide, with the exception of nonmelanoma skin tumors. The nipple-areola complex (NAC)-sparing mastectomy was developed with the aim of improving aesthetic results and psychological impact on patients. The oncological safety of this technique has been well established in early-stage tumors and risk-reducing surgery; however, it is still uncertain in patients undergoing neoadjuvant chemotherapy who are often at a higher risk for relapse. Objectives: This study aims to analyze the oncologic outcome in a retrospective cohort of patients that were submitted to mastectomy with preservation of the NAC after neoadjuvant chemotherapy for breast cancer treatment, and to correlate clinicopathological and magnetic resonance (MRI) variables to NAC local relapse. Methods: All the patients who were submitted to nipple-sparing mastectomy after neoadjuvant chemotherapy at the Centro de Doenças de Mama de Curitiba, in the period from January 1, 2012, to December 31, 2019, for breast cancer curative treatment were selected. Patients who had incomplete data in their medical records or who were lost to follow-up were excluded. Local and systemic recurrence rates and clinicopathological and MRI variables associated with the oncological outcome were analyzed. To evaluate factors associated with the incidence of recurrence, the Fine and Gray models were adjusted, considering death as a competitive risk. The estimated association measure was the subdistribution hazard ratio (SHR), for which the 95% confidence interval was presented. After adjusting the models, the significance of each variable was analyzed using the Wald test. Values of p <0.05 indicated statistical significance. Results: In all, 134 patients were included, with a mean age of 42.3±10.1 (23–68) years in an average follow-up time of 44.5 (4.2–148) months. The locoregional recurrence rate in the sample was 9.7% (13 cases) in a median time of 17.8 (4.5–40) months; in 5 of these 13 cases, the local relapse involved the nipple-areolar complex corresponding to 3.7% of the sample in a median time of 24.2 (11.7–40.1) months. The systemic recurrence rate was 11.9% (16 cases) in a median time of 20.9 (2.7–130) months. There were 12 deaths (9%) in this sample, in a median follow-up time of 37.8 (4.6–98.4) months. Stage 3 tumors (p=0.016, SHR) and Ki67 index (p=0.004) were significantly associated with local and/or systemic recurrence risk. There was found no association between the NAC recurrence and multicentricity/multifocality presentation (p=0.716; SHR 1.39, 95%CI 0.23–8.30), tumor size on prechemotherapy MRI (p=0.934; SHR 1.00, 95%CI 0.96–1.05), or the distance from the tumor to the NAC on pre (p=0.866; SHR 0.99, 95%CI 0.92–1.08) or pos chemotherapy MRI (p=0.205; SHR 1.03, 95%CI 0.98–1.09). Adjuvant radiotherapy was also a nonsignificant factor. When analyzing immunohistochemical parameters, the Ki67 index was the only variable that was correlated (p=0.018; SHR 1.04, 95%CI 1.01–1.08) to the locoregional failure in the NAC. Conclusion: Locoregional relapse rate in NAC was within acceptable limits for performing nipple-sparing mastectomy in patients submitted to neoadjuvant chemotherapy in this sample. More studies are needed to confirm the safety of this technique, especially in the stage 3 subgroup of patients.

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Drabble, EH. « Abstract P2-14-02 : Get skin sparing mastectomy right : Reduce local recurrence rate by meticulous removal all breast tissue ». Dans Abstracts : 2018 San Antonio Breast Cancer Symposium ; December 4-8, 2018 ; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p2-14-02.

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Rapports d'organisations sur le sujet "Skin recurrences"

Tang, Liheng, Jin Xian, Ye Zhang, Changyun Zhang, Huijuan Yu, Qiwen Tan et Xin Zhang. Efficacy of acupuncture for melasma : a protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, novembre 2021. http://dx.doi.org/10.37766/inplasy2021.11.0097.

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Review question / Objective: How effective is acupuncture in treating melasma compared to conventional treatment？ Condition being studied: Melasma is a common acquired hyperpigmentation of the skin. The clinical manifestations are light brown or dark brown patches symmetrically distributed on the cheeks, forehead and mandibular with different shades and unclear borders. Melasma particularly affects women during menstruation, especially in thirties and forties Asian women. The incidence of Asian women of childbearing age is as high as 30%. Current treatments for melasma include topical drugs, chemical peeling agents, laser and light treatments, and systemic drugs. Despite the strong demand for treatment, the treatment of melasma is still very challenging, the results are inconsistent, and the recurrence rate is almost constant.

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