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Littérature scientifique sur le sujet « SOX6, Cell differentiation »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "SOX6, Cell differentiation"

Han, Yu, and Véronique Lefebvre. "L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer." Molecular and Cellular Biology 28, no. 16 (2008): 4999–5013. http://dx.doi.org/10.1128/mcb.00695-08.

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ABSTRACT The Sry-related high-mobility-group box transcription factor Sox9 recruits the redundant L-Sox5 and Sox6 proteins to effect chondrogenesis, but the mode of action of the trio remains unclear. We identify here a highly conserved 359-bp sequence 10 kb upstream of the Agc1 gene for aggrecan, a most essential cartilage proteoglycan and key marker of chondrocyte differentiation. This sequence directs expression of a minimal promoter in both embryonic and adult cartilage in transgenic mice, in a manner that matches Agc1 expression. The chondrogenic trio is required and sufficient to mediate

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Smits, Patrick, Peter Dy, Srijeet Mitra, and Véronique Lefebvre. "Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate." Journal of Cell Biology 164, no. 5 (2004): 747–58. http://dx.doi.org/10.1083/jcb.200312045.

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Sox5 and Sox6 encode Sry-related transcription factors that redundantly promote early chondroblast differentiation. Using mouse embryos with three or four null alleles of Sox5 and Sox6, we show that they are also essential and redundant in major steps of growth plate chondrocyte differentiation. Sox5 and Sox6 promote the development of a highly proliferating pool of chondroblasts between the epiphyses and metaphyses of future long bones. This pool is the likely cellular source of growth plates. Sox5 and Sox6 permit formation of growth plate columnar zones by keeping chondroblasts proliferating

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Saad, Eman A., Rana M. Abdalla, and Mona A. Aboelkheir. "Significance of sex-determining region Y box family members (SOX6 and SOX9) in clear cell renal cell carcinoma: immunohistochemical study." Egyptian Journal of Pathology 44, no. 2 (2024): 183–89. https://doi.org/10.4103/egjp.egjp_27_24.

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Background Renal cell carcinoma (RCC) ranks as the third most common urological malignancy worldwide, comprising ~2.2% of all cancers. The clear cell subtype, which accounts for 80–90% of RCC cases, is characterized by a wide spectrum of survival outcomes. The sex-determining region Y box (SOX) family of proteins, expressed in multiple cell types, plays a crucial role in regulating cell differentiation and fate in various physiological contexts. Among them, SOX6 and SOX9 have been implicated in the regulation of carcinogenesis in several human cancers. Aim The primary objective of this study i

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Cantù, Claudio, Rossella Ierardi, Ilaria Alborelli, et al. "Sox6 enhances erythroid differentiation in human erythroid progenitors." Blood 117, no. 13 (2011): 3669–79. http://dx.doi.org/10.1182/blood-2010-04-282350.

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Abstract Sox6 belongs to the Sry (sex-determining region Y)–related high-mobility-group–box family of transcription factors, which control cell-fate specification of many cell types. Here, we explored the role of Sox6 in human erythropoiesis by its overexpression both in the erythroleukemic K562 cell line and in primary erythroid cultures from human cord blood CD34+ cells. Sox6 induced significant erythroid differentiation in both models. K562 cells underwent hemoglobinization and, despite their leukemic origin, died within 9 days after transduction; primary erythroid cultures accelerated thei

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Guimont, Philippe, Francine Grondin, and Claire M. Dubois. "Sox9-dependent transcriptional regulation of the proprotein convertase furin." American Journal of Physiology-Cell Physiology 293, no. 1 (2007): C172—C183. http://dx.doi.org/10.1152/ajpcell.00349.2006.

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The proprotein convertase furin participates in the maturation/bioactivation of a variety of proproteins involved in chondrogenesis events. These include parathyroid hormone-related peptide (PTHrP), an autocrine/paracrine factor that is crucial to both normal cartilage development and cartilage-related pathological processes. Despite the known importance of furin activity in the bioactivation of the polypeptides, the mechanisms that control furin regulation in chondrogenesis remain unknown. To gain insight into the molecular regulation of furin, we used the mouse prechondrogenic ATDC5 cell lin

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Amano, Katsuhiko, Kenji Hata, Atsushi Sugita, et al. "Sox9 Family Members Negatively Regulate Maturation and Calcification of Chondrocytes through Up-Regulation of Parathyroid Hormone–related Protein." Molecular Biology of the Cell 20, no. 21 (2009): 4541–51. http://dx.doi.org/10.1091/mbc.e09-03-0227.

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Sox9 is a transcription factor that plays an essential role in chondrogenesis and has been proposed to inhibit the late stages of endochondral ossification. However, the molecular mechanisms underlying the regulation of chondrocyte maturation and calcification by Sox9 remain unknown. In this study, we attempted to clarify roles of Sox9 in the late stages of chondrocyte differentiation. We found that overexpression of Sox9 alone or Sox9 together with Sox5 and Sox6 (Sox5/6/9) inhibited the maturation and calcification of murine primary chondrocytes and up-regulated parathyroid hormone–related pr

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Binlateh, Thunwa, Supita Tanasawet, Onnicha Rattanaporn, Wanida Sukketsiri, and Pilaiwanwadee Hutamekalin. "Metformin Promotes Neuronal Differentiation via Crosstalk between Cdk5 and Sox6 in Neuroblastoma Cells." Evidence-Based Complementary and Alternative Medicine 2019 (February 19, 2019): 1–13. http://dx.doi.org/10.1155/2019/1765182.

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Metformin has recently emerged as a key player in promotion of neuroblastoma differentiation and neurite outgrowth. However, molecular mechanisms of how metformin promotes cellular differentiation have not yet been fully elucidated. In this study, we investigated how metformin promotes cell differentiation, via an inhibition of cell proliferation, by culturing SH-SY5Y neuroblastoma cells with or without metformin. Pretreatment with reactive oxygen species (ROS) scavenger, NAC, revealed that ROS plays a crucial role in induction of cell differentiation. Cell differentiation was observed under v

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Dumitriu, Bogdan, Michael R. Patrick, Jane P. Petschek, et al. "Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development." Blood 108, no. 4 (2006): 1198–207. http://dx.doi.org/10.1182/blood-2006-02-004184.

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Abstract Erythropoiesis, the essential process of hematopoietic stem cell development into erythrocytes, is controlled by lineage-specific transcription factors that determine cell fate and differentiation and by the hormone erythropoietin that stimulates cell survival and proliferation. Here we identify the Sry-related high-mobility-group (HMG) box transcription factor Sox6 as an important enhancer of definitive erythropoiesis. Sox6 is highly expressed in proerythroblasts and erythroblasts in the fetal liver, neonatal spleen, and bone marrow. Mouse fetuses and pups lacking Sox6 develop erythr

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Haseeb, Abdul, and Véronique Lefebvre. "The SOXE transcription factors—SOX8, SOX9 and SOX10—share a bi-partite transactivation mechanism." Nucleic Acids Research 47, no. 13 (2019): 6917–31. http://dx.doi.org/10.1093/nar/gkz523.

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Abstract SOX8, SOX9 and SOX10 compose the SOXE transcription factor group. They govern cell fate and differentiation in many lineages, and mutations impairing their activity cause severe diseases, including campomelic dysplasia (SOX9), sex determination disorders (SOX8 and SOX9) and Waardenburg-Shah syndrome (SOX10). However, incomplete knowledge of their modes of action limits disease understanding. We here uncover that the proteins share a bipartite transactivation mechanism, whereby a transactivation domain in the middle of the proteins (TAM) synergizes with a C-terminal one (TAC). TAM comp

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Li, Yi, Ming Xiao, and Fangchun Guo. "The role of Sox6 and Netrin-1 in ovarian cancer cell growth, invasiveness, and angiogenesis." Tumor Biology 39, no. 5 (2017): 101042831770550. http://dx.doi.org/10.1177/1010428317705508.

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SOX6 plays important roles in cell proliferation, differentiation, and cell fate determination. It has been confirmed that SOX6 is a tumor suppressor and downregulated in various cancers, including esophageal squamous cell carcinoma, hepatocellular carcinoma, and chronic myeloid leukemia. Netrin-1 is highly expressed in various human cancers and acts as an anti-apoptotic and proangiogenic factor to drive tumorigenesis. The role of SOX6 and netrin-1 in regulating the growth of ovarian tumor cells still remains unclear. Real-time polymerase chain reaction and western blot were used to determine

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Thèses sur le sujet "SOX6, Cell differentiation"

BARBARANI, GLORIA. "The transcription factor Sox6 induces differentiation and cell cycle withdrawal in BCR-ABL+ and JAK2 V617F+ cellular model systems of leukemia." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/113929.

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SOX6 is a transcription factor (TF) belonging to the Sry-related HMG-box TFs family. It controls terminal differentiation and lineage specification of many cell types, by mediating cell cycle withdrawal and activation of lineage specific genes. In hematopoiesis, Sox6 sustains cell survival, proliferation and terminal maturation of murine erythroid cells. To explore the role of SOX6 in human erythropoiesis, we first overexpressed it in erythroleukemic BCR-ABL+ K562 cell line. In these cells, Sox6 overexpression induces a strong erythroid differentiation coupled with growth arrest. This last ef

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Moleri, S. "Sox18 and Sox7 play redundant roles in endothelial cell differentiation." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/56632.

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The main focus of our laboratory is clarifying the roles of DNA binding proteins belonging to the HMG box superfamily during embryonic development. In particular, I studied Sox18 and Sox7 in zebrafish and our data show that they act redundantly in vascular development. Mutations in SOX18 have been associated with Hypotrichosis-Lymphedema-Telangiectasia (HLT), a human syndrome combining defects in hair follicle, blood and lymphatic vessels development. Similarly, spontaneous mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice, including symptoms of lymphatic dysf

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Stavridis, Marios Pericles. "Construction and use of a Sox1 reporter cell line to study embryonic stem cell differentiation." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/14484.

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Sox1 is upregulated during ES cell differentiation into neural precursors, and its misexpression causes an EC cell line to differentiate into neurons. Sox1 expression during nervous system development is associated with proliferating cells of the CNS, expression being lost as cells exist mitosis and terminally differentiate. Its expression pattern is more restricted than that of most other markers for early neural cells such as nestin, making it a good marker gene for the study of neural development both in vivo and in vitro from ES cells. Here I have used gene targ

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Okolicsanyi, Rachel K. "Mesenchymal stem cells as mediators of the neuronal cell niche." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84485/1/Rachel_Okolicsanyi_Thesis.pdf.

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This study examined the role of heparan sulfate proteoglycans (HSPGs) in neural lineage differentiation of human mesenchymal stem cells (hMSCs). Several HSPGs were identified as potential new targets controlling neural fate specification and may be applied to the development of improved models to examine and repair brain damage. hMSCs were characterised throughout extended in vitro expansion for neural lineage potential (neurons, astrocytes, oligodendrocytes) and differentiated using terminal differentiation and intermediate sphere formation. Brain damage and neurological disorders caused by i

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Ghanem, A. M. "Molecular regulation of Sox2 expression during differentiation of chick embryonic stem cells." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/133262/.

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The transcription factor Sox2 has a key role not only in maintaining stem state but also in specification of neural fate of embryonic cells. Multiple regulatory elements have been identified in the Sox2 locus (Uchikawa et al, 2003). In the developing embryo, these regulatory elements are activated differentially in time and space. We studied the activity of 25 defined regulatory elements of the Sox2 promoter in three different lines of chick ES cells. By transfection of plasmids encoding Enhanced Green Fluorescent Protein (EGFP) and the minimal promoter thymidine kinase (tk) coupled with indiv

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Yagi, Rieko. "Bcl-2 Regulates Chondrocyte Phenotype Through MEK-ERK1/2 Pathway; Relevance to Osteoarthritis and Cartilage Biology." [Kent, Ohio] : Kent State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1118329494.

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Thesis (Ph.D.)--Kent State University, 2005. Title from PDF t.p. (viewed Sept. 5, 2006). Advisor: Walter E. Horton. Keywords: chondrocytes; osteoarthritis; Sox9; Bcl-2; MEK-ERK 1/2. Includes bibliographical references (p. 91-106).

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MARIANI, JESSICA. "Transcriptional regulation, target genes and functional roles of the SOX2 transcription factor in mouse neural stem cells maintenance and neuronal differentiation." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/8321.

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The aims of this PhD research were: to examine molecular mechanisms underlying the transcriptional regulation of the Sox2 gene during forebrain development; to examine the role of Sox2 for the proper neuronal differentiation of neural stem cells; and to examine the role of Sox2 in controlling the maintenance of neural stem cells (in vivo and in vitro). The aim of the first work (Chapter 1) was to investigate the transcription factors and the regulatory sequences that control transcription of the Sox2 gene in the developing brain and neural stem cells. Our laboratory previously identified Sox2

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Kimura, Yoshito. "ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice." Kyoto University, 2018. http://hdl.handle.net/2433/235986.

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Al-Asaad, Imane. "Étude de marqueurs de différenciation testiculaire Sox9 et Amh lors d'un développement normal, d'une inversion sexuelle et d'un développement en absence de cellules germinales chez l'amphibien urodèle Pleurodeles waltl. Intérêt pour la physiologie comparée de la reproduction des vertébrés." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0229/document.

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Dans le contexte de la physiologie comparée de la reproduction, les amphibiens sont peu étudiés. Le travail réalisé durant cette thèse visait à analyser des marqueurs de différenciation testiculaire chez l'urodèle Pleurodeles waltl, dont le déterminisme génétique du sexe (ZZ/ZW) peut être influencé par la température. Nos études ont d'abord porté sur le gène sox9 marqueur de la différenciation testiculaire chez les vertébrés supérieurs. Le gène cloné chez le pleurodèle montre une bonne conservation par rapport aux autres vertébrés. Son expression plus élevée dans la gonade mâle n'apparaît que

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Kaur, Navdeep. "Influence of culture conditions on the molecular signature of mesenchymal stem cells." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/43719/1/Navdeep_Kaur_Thesis.pdf.

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Cell based therapies require cells capable of self renewal and differentiation, and a prerequisite is the ability to prepare an effective dose of ex vivo expanded cells for autologous transplants. The in vivo identification of a source of physiologically relevant cell types suitable for cell therapies is therefore an integral part of tissue engineering. Bone marrow is the most easily accessible source of mesenchymal stem cells (MSCs), and harbours two distinct populations of adult stem cells; namely hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs). Unlike HSCs, there ar

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Chapitres de livres sur le sujet "SOX6, Cell differentiation"

Lucchesi, John C. "Stem cells." In Epigenetics, Nuclear Organization & Gene Function. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198831204.003.0017.

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The zygote and the very early cells are totipotent because they can produce a whole organism. Later, cells become pluripotent because they can differentiate into different subgroups of tissues. These cells can be extracted as embryonic stem cells (ESCs). Their pluripotent nature is due to the action of the pioneer transcription factors Oct4, Sox2 and Nanog. Multipotent or progenitor stem cells are present in adult organisms where they can differentiate into the various cells present in specific tissues. Differentiation depends on their microenvironment or niche. Differentiation of stem cells r

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Huang A., Qiu Y., and Sun G. "Expression and significance of Sox9 in chondrocyte cells from adolescent idiopathic scoliosis patients." In Studies in Health Technology and Informatics. IOS Press, 2008. https://doi.org/10.3233/978-1-58603-888-5-324.

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Although it is now widely accepted that growth is related strongly to the onset and progression of scoliosis, the pathomechanism or etiology of idiopathic scoliosis still is not clear. In mammals, most skeletal elements are formed through endochondral bone formation. Several studies demonstrate that Sox9 as the first transcription factor that is essential for chondrocyte differentiation and cartilage formation. To investigate a possible related molecular mechanism between pathogenesis of adolescent idiopathic scoliosis (AIS) and expression of Sox9 from chondrocyte level. The study include 15 A

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Rai, Vikas. "Neurons, Glial Cells and Imaging." In The Brain: A Systems Neuroscience Perspective. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815256987124010003.

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Scientists at the European Molecular Biology Laboratory have investigated how embryonic stem cells become mature nerve cells. They assessed the complex interplay of molecules during the differentiation process. Consequently, new insights into the role of a protein called SOX2 in neurons emerged. This protein is expressed by a gene, SOX2, located on chromosome 3 in humans. This gene is a sex-determining Yrelated HMG box2 and serves as a marker for neural stem and progenitor cells [1]. Progenitor stem cells become neurons and glial cells. The ratio of glia to neurons in the human brain is 10:1.

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Lucchesi, John C. "Nuclear reprogramming and induced pluripotency." In Epigenetics, Nuclear Organization & Gene Function. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198831204.003.0018.

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Four core transcription factors known to maintain the pluripotent state in embryonic stem cells (ESCs)—Oct4, Sox2, Klf4 and c-Myc—were used to induce pluripotent stem cells in adult-derived fibroblasts. Induced pluripotent stem cells (iPSCs), like ESCs, have less condensed and more transcriptionally active chromatin than differentiated cells. The number of genes with bivalent promoter marks increases during reprogramming, reflecting the switch of differentiation-specific active genes to an inactive, but poised, status. The levels of DNA methyl transferases and demethylases are increased, under

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Adachi, Keiko, Hirofumi Suemori, Norio Nakatsuji, and Eihachiro Kawase. "The Role of SOX2 in Maintaining Pluripotency and Differentiation of Human Embryonic Stem Cells." In Stem Cells in Clinic and Research. InTech, 2011. http://dx.doi.org/10.5772/23094.

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Mondal, Susmita, Sutapa Saha, Saptarshi Chatterjee, and Biplab Bhowmik. "Chemoresistance of Cervical Cancer Stem Cells: Challenges and Prospects." In Life as Basic Science: An Overview and Prospects for the Future [Volume: 1]. International Academic Publishing House (IAPH), 2024. http://dx.doi.org/10.52756/lbsopf.2024.e01.016.

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Cervical cancer (CC) is one of the leading causes of death among women, with thousands of women diagnosed each year, particularly in developing countries where access to healthcare resources may be limited. Persistent infection with high-risk human papillomavirus (HPV) induces CC. While advancements in treatment modalities, such as chemotherapy, have improved outcomes for many patients, a significant challenge remains in the form of chemoresistance, particularly in the context of cervical cancer stem cells (cCSCs). cCSCs are a small subpopulation of cells within CC with self-renewal and aberra

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Osuna, Marumi, Hideji Yako, Saishu Yoshida, et al. "S100b-Expressing Folliculo-Stellate Cells Are Found in SOX2-Positive Population in the Anterior Pituitary Lobe and Show Multiple Differentiation Capacities in the Defined Culture Conditions." In BASIC/TRANSLATIONAL - Pituitary Biology & Tumorigenesis. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part2.p2.p1-386.

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Actes de conférences sur le sujet "SOX6, Cell differentiation"

Abdel-Sayed, Philippe, Arne Vogel, and Dominique P. Pioletti. "Dissipation Can Act as a Mechanobiological Signal in Cartilage Differentiation." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-62268.

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Knee cartilage is a soft tissue having viscoelastic properties. Under cyclic loadings, viscoelastic materials dissipate mechanical loadings through heat generation. In knee cartilage, this heat might not be convected because of the tissue avascularity, resulting thus to a local temperature increase. As cells are sensitive to temperature, these thermo-mechanical phenomena of energy dissipation could influence their metabolism. The goal of this study is to evaluate the effect of thermogenesis on chondrogenic differentiation. First, we focused our work in quantifying the heat generated in cartila

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Singh, Ankur, Shalu Suri, Ted T. Lee, et al. "Adhesive Signature-Based, Label-Free Isolation of Human Pluripotent Stem Cells." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80044.

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Generation of human induced pluripotent stem cells (hiPSCs) from fibroblasts and other somatic cells represents a highly promising strategy to produce auto- and allo-genic cell sources for therapeutic approaches as well as novel models of human development and disease1. Reprogramming protocols involve transduction of the Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc into the parental somatic cells, followed by culturing the transduced cells on mouse embryonic fibroblast (MEF) or human fibroblast feeder layers, and subsequent mechanical dissociation of pluripotent cell-like colonies for propag

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Thobakgale, Lebogang, Sello Lebohang Manoto, Satuurnin Ombinda Lemboumba, Malik Maaza, and Patience Mthunzi-Kufa. "Efficient femtosecond driven SOX 17 delivery into mouse embryonic stem cells: differentiation studies." In SPIE BiOS, edited by Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif. SPIE, 2017. http://dx.doi.org/10.1117/12.2252255.

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Guarnerio, Jlenia, Andrea Lunardi, and Pier Paolo Pandolfi. "Abstract 601: Essential role of LRF in mesenchymal stem cell differentiation and tumorigenesis through Dlk1 and Sox9 repression." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-601.

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Lazic, Stefan, Filip Duzanic, Danijela Stanisavljevic Ninkovic, et al. "Hypoxia affects the expression of SOX genes and induction of neural differentiation of human embryonal carcinoma NT2/D1 cells." In RAD Conference. RAD Centre, 2022. http://dx.doi.org/10.21175/rad.spr.abstr.book.2022.22.2.

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Rapports d'organisations sur le sujet "SOX6, Cell differentiation"

จันทรวิสูตร, นพัต. การใช้ Differentiation Therapy ในการเปลี่ยนแปลงสภาวะเหนือพันธุกรรมและความรุนแรงของเซลล์มะเร็งในการรักษามะเร็งสมองชนิดกลัยโอบลาสโตมา. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2018. https://doi.org/10.58837/chula.res.2018.38.

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มะเร็งสมองชนิดกลัยโอบาสโตมา (Glioblastoma) เป็นมะเร็งสมองชนิดที่พบมากที่สุด และมีความรุนแรงมากที่สุดชนิดหนึ่งเมื่อเทียบกับมะเร็งชนิดอื่น ๆ โดยมีอัตราการรอดชีวิตของผู้ป่วยต่ำ เนื่องจากทางเลือกของวิธีการรักษามีน้อย และผู้ป่วยมักเกิดการกลับเป็นซ้ำ นำมาซึ่งความจำเป็นในการศึกษาเพิ่มเติมเกี่ยวกับชีววิทยาของเซลล์มะเร็งชนิดนี้ เพื่อเพิ่มความเข้าใจที่จะทำให้นำไปสู่หนทางการรักษาได้ในอนาคต การศึกษาวิจัยนี้ต้องการศึกษาความสัมพันธ์ระหว่างความรุนแรงของมะเร็งสมองชนิดกลัยโอบลาสโตมา กับการแสดงออกของยีนที่มีความเกี่ยวข้องกับความเป็นเซลล์ต้นกำเนิด (Stemness-related genes) โดยเฉพาะ LIN28/let-7 pathway และวิถีการส

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