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Articles de revues sur le sujet « Sp/KLFs factor »

Auteur : Grafiati

Publié le 1 avril 2023

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1

Ilsley, Melissa, Kevin R. Gillinder, Graham Magor, Merlin Crossley, and Andrew C. Perkins. "Fine-Tuning Erythropoiesis By Competition Between Krüppel-like Factors for Promoters and Enhancers." Blood 128, no. 22 (2016): 1036. http://dx.doi.org/10.1182/blood.v128.22.1036.1036.

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Abstract Krüppel-like factors (KLF) are a group of 17 transcription factors with highly conserved DNA-binding domains that contain three C-terminal C2H2-type zinc fingers and a variable N-terminal domain responsible for recruiting cofactors 1. KLFs participate in diverse roles in stem cell renewal, early patterning, organogenesis and tissue homeostasis. Krüppel-like factor 1 (KLF1) is an erythroid-specific KLF responsible for coordinating many aspects of terminal erythroid differentiation 2. It functions as a transcriptional activator by recruiting cofactors such as p300 and chromatin modifier

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Simmen, R. C. M., J. M. P. Pabona, M. C. Velarde, C. Simmons, O. Rahal, and F. A. Simmen. "The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues." Journal of Endocrinology 204, no. 3 (2009): 223–31. http://dx.doi.org/10.1677/joe-09-0329.

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Krüppel-like factors (KLFs), of which there are currently 17 known protein members, belong to the specificity protein (Sp) family of transcription factors and are characterized by the presence of Cys2/His2 zinc finger motifs in their carboxy-terminal domains that confer preferential binding to GC/GT-rich sequences in gene promoter and enhancer regions. While previously regarded to simply function as silencers of Sp1 transactivity, many KLFs are now shown to be relevant to human cancers by their newly identified abilities to mediate crosstalk with signaling pathways involved in the control of c

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Fernandez-Zapico, Martin E., Gwen A. Lomberk, Shoichiro Tsuji, et al. "A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth." Biochemical Journal 435, no. 2 (2011): 529–37. http://dx.doi.org/10.1042/bj20100773.

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SP/KLF (Specificity protein/Krüppel-like factor) transcription factors comprise an emerging group of proteins that may behave as tumour suppressors. Incidentally, many cancers that display alterations in certain KLF proteins are also associated with a high incidence of KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue) mutations. Therefore in the present paper we investigate whether SP/KLF proteins suppress KRAS-mediated cell growth, and more importantly, the potential mechanisms underlying these effects. Using a comprehensive family-wide screening of the 24 SP/KLF members, we disco

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Ulfhammer, Erik, Pia Larsson, Mia Magnusson, Lena Karlsson, Niklas Bergh, and Sverker Jern. "Dependence of Proximal GC Boxes and Binding Transcription Factors in the Regulation of Basal and Valproic Acid-Induced Expression of t-PA." International Journal of Vascular Medicine 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/7928681.

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Objective.Endothelial tissue-type plasminogen activator (t-PA) release is a pivotal response to protect the circulation from occluding thrombosis. We have shown that the t-PA gene is epigenetically regulated and greatly induced by the histone deacetylase (HDAC) inhibitor valproic acid (VPA). We now investigated involvement of known t-PA promoter regulatory elements and evaluated dependence of potential interacting transcription factors/cofactors.Methods.A reporter vector with an insert, separately mutated at either the t-PA promoter CRE or GC box II or GC box III elements, was transfected into

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Funnell, Alister P. W., Christopher A. Maloney, Lucinda J. Thompson, et al. "Erythroid Krüppel-Like Factor Directly Activates the Basic Krüppel-Like Factor Gene in Erythroid Cells." Molecular and Cellular Biology 27, no. 7 (2007): 2777–90. http://dx.doi.org/10.1128/mcb.01658-06.

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ABSTRACT The Sp/Krüppel-like factor (Sp/Klf) family is comprised of around 25 zinc finger transcription factors that recognize CACCC boxes and GC-rich elements. We have investigated basic Krüppel-like factor (Bklf/Klf3) and show that in erythroid tissues its expression is highly dependent on another family member, erythroid Krüppel-like factor (Eklf/Klf1). We observe that Bklf mRNA is significantly reduced in erythroid tissues from Eklf-null murine embryos. We find that Bklf is driven primarily by two promoters, a ubiquitously active GC-rich upstream promoter, 1a, and an erythroid downstrea

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Gillinder, Kevin R., Graham Magor, Charles Bell, Melissa D. Ilsley, Stephen Huang, and Andrew Perkins. "KLF1 Acts As a Pioneer Transcription Factor to Open Chromatin and Facilitate Recruitment of GATA1." Blood 132, Supplement 1 (2018): 501. http://dx.doi.org/10.1182/blood-2018-99-119608.

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Abstract Only a small subset of transcription factors (TFs) can act as pioneer factors; i.e. those that can 'open' otherwise 'closed' chromatin to facilitate assembly of TF complexes and co-factors to enable transcription. The KLF/SP family of TFs bind to a 9-10 bp consensus motif in DNA to activate or repress target gene expression. We have studied the potential for KLF1, which is essential for erythropoiesis, to provide a pioneering function in erythroid progentior cells. Previous ChIP-seq studies have shown KLF1 binds a few thousand enhancers and promoters to activate erythroid cell gene ex

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Orzechowska-Licari, Emilia J., Joseph F. LaComb, Aisharja Mojumdar, and Agnieszka B. Bialkowska. "SP and KLF Transcription Factors in Cancer Metabolism." International Journal of Molecular Sciences 23, no. 17 (2022): 9956. http://dx.doi.org/10.3390/ijms23179956.

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Tumor development and progression depend on reprogramming of signaling pathways that regulate cell metabolism. Alterations to various metabolic pathways such as glycolysis, oxidative phosphorylation, lipid metabolism, and hexosamine biosynthesis pathway are crucial to sustain increased redox, bioenergetic, and biosynthesis demands of a tumor cell. Transcription factors (oncogenes and tumor suppressors) play crucial roles in modulating these alterations, and their functions are tethered to major metabolic pathways under homeostatic conditions and disease initiation and advancement. Specificity

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Hong, Jie, George Stamatoyannopoulos, and Chao-Zhong Song. "Regulation of Globin Gene Expression and Erythroid Differentiation by Sp/KLF Factors." Blood 106, no. 11 (2005): 4241. http://dx.doi.org/10.1182/blood.v106.11.4241.4241.

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Abstract Sp/Krüppel-like factor (KLF) family of proteins are characterized by the presence of three highly homologous Cys2His2 type zinc-fingers near the C-terminus that bind GC/CACCC boxes, which are one of the most common regulatory elements found in promoters of many cellular and viral genes. Currently, more than 20 members have been identified in the family. This family of factors plays important roles in cell growth, differentiation, development and homeostasis by regulating the expression of their target genes. The GC and GT/CACCC boxes in the globin gene promoters and the beta globin l

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Wittner, Jens, Sebastian R. Schulz, Tobit Steinmetz, et al. "Krüppel-Like-Factor 2, a new player in mucosal IgA homeostasis." Journal of Immunology 204, no. 1_Supplement (2020): 235.10. http://dx.doi.org/10.4049/jimmunol.204.supp.235.10.

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Abstract Krüppel-Like-Factor 2 (KLF2) is a transcription factor that controls organ development, differentiation and trafficking of cells. In the immune system, KLF2 fosters the egress of T lymphocytes from the thymus via S1PR1 and promotes quiescent states of B lymphocytes as well as homing of antigen-specific IgG plasmablasts (PB) and plasma cells (PC) to the bone marrow (BM) via the α4β7 receptor. To investigate the PC-specific role of KLF2, we analyzed CD138+/TACI+ PB/PC subpopulations and isotype changes in various organs such as spleen (SP), BM, gut associated lymphoid tissues (GALT) and

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Lei, Lijuan, Minghua Chen, Chenyin Wang та ін. "Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation". International Journal of Molecular Sciences 23, № 21 (2022): 13477. http://dx.doi.org/10.3390/ijms232113477.

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Krüppel-like factor 2 (KLF2) is an atherosclerotic protective transcription factor that maintains endothelial cell homeostasis through its anti-inflammatory, anti-oxidant, and antithrombotic properties. The aim of this study was to discover KLF2 activators from microbial secondary metabolites and explore their potential molecular mechanisms. By using a high-throughput screening model based on a KLF2 promoter luciferase reporter assay, column chromatography, electrospray ionization mass spectrometry (ESI-MS), and nuclear magnetic resonance (NMR) spectra, trichostatin D (TSD) was isolated from t

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Suske, Guntram, Elspeth Bruford, and Sjaak Philipsen. "Mammalian SP/KLF transcription factors: Bring in the family." Genomics 85, no. 5 (2005): 551–56. http://dx.doi.org/10.1016/j.ygeno.2005.01.005.

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Kim, Chang-Kyung, Ping He, Agnieszka B. Bialkowska, and Vincent W. Yang. "SP and KLF Transcription Factors in Digestive Physiology and Diseases." Gastroenterology 152, no. 8 (2017): 1845–75. http://dx.doi.org/10.1053/j.gastro.2017.03.035.

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Presnell, Jason S., Christine E. Schnitzler, and William E. Browne. "KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes." Genome Biology and Evolution 7, no. 8 (2015): 2289–309. http://dx.doi.org/10.1093/gbe/evv141.

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Singh, Parul, Natalia Kunz, Gaelle Le Friec, et al. "A novel and human-specific CD46-KLF/SP interaction mediates gene expression required for successful Th1 induction." Journal of Immunology 204, no. 1_Supplement (2020): 76.13. http://dx.doi.org/10.4049/jimmunol.204.supp.76.13.

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Abstract Signals mediated by autocrine activation of the human-specific complement receptor CD46 during T cell receptor (TCR) stimulation are vital to Th1 induction in human CD4+ T cells, but how exactly CD46 in a molecular level mediates this role is currently undefined. CD46 is expressed in different isoforms that can bear either one of two distinct cytoplasmic tails: CYT-1 or CYT-2. Nuclear translocation of CYT-1 is a critical requirement for the expression of genes coding for nutrient-influx-channels and mTORC1 activity that mediate metabolic adaptations needed for Th1 responses. The lack

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McCulloch, Kyle J., and Kristen M. Koenig. "Krüppel-like factor/specificity protein evolution in the Spiralia and the implications for cephalopod visual system novelties." Proceedings of the Royal Society B: Biological Sciences 287, no. 1937 (2020): 20202055. http://dx.doi.org/10.1098/rspb.2020.2055.

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The cephalopod visual system is an exquisite example of convergence in biological complexity. However, we have little understanding of the genetic and molecular mechanisms underpinning its elaboration. The generation of new genetic material is considered a significant contributor to the evolution of biological novelty. We sought to understand if this mechanism may be contributing to cephalopod-specific visual system novelties. Specifically, we identified duplications in the Krüppel-like factor/specificity protein (KLF/SP) sub-family of C2H2 zinc-finger transcription factors in the squid Doryte

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Shi, Lewis Zhichang, Jordy Saravia, Hu Zeng, et al. "Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes." Proceedings of the National Academy of Sciences 114, no. 1 (2016): E67—E74. http://dx.doi.org/10.1073/pnas.1617669114.

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Double-positive (DP) thymocytes respond to intrathymic T-cell receptor (TCR) signals by undergoing positive selection and lineage differentiation into single-positive (SP) mature cells. Concomitant with these well-characterized events is the acquisition of a mature T-cell gene expression program characterized by the induction of the effector molecules IL-7Rα, S1P1, and CCR7, but the underlying mechanism remains elusive. We report here that transcription repressor Growth factor independent 1 (Gfi1) orchestrates the fidelity of the DP gene expression program and developmental maturation into SP

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Yerra, Veera Ganesh, and Konstantinos Drosatos. "Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology." International Journal of Molecular Sciences 24, no. 5 (2023): 4682. http://dx.doi.org/10.3390/ijms24054682.

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The liver acts as a central hub that controls several essential physiological processes ranging from metabolism to detoxification of xenobiotics. At the cellular level, these pleiotropic functions are facilitated through transcriptional regulation in hepatocytes. Defects in hepatocyte function and its transcriptional regulatory mechanisms have a detrimental influence on liver function leading to the development of hepatic diseases. In recent years, increased intake of alcohol and western diet also resulted in a significantly increasing number of people predisposed to the incidence of hepatic d

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Daftary, Gaurang S., Ye Zheng, Zaid M. Tabbaa, et al. "A Novel Role of the Sp/KLF Transcription Factor KLF11 in Arresting Progression of Endometriosis." PLoS ONE 8, no. 3 (2013): e60165. http://dx.doi.org/10.1371/journal.pone.0060165.

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van Vliet, Jane, Linda A. Crofts, Kate G. R. Quinlan, Robert Czolij, Andrew C. Perkins, and Merlin Crossley. "Human KLF17 is a new member of the Sp/KLF family of transcription factors." Genomics 87, no. 4 (2006): 474–82. http://dx.doi.org/10.1016/j.ygeno.2005.12.011.

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Kennedy, Mark W., Ravindra B. Chalamalasetty, Sara Thomas, Robert J. Garriock, Parthav Jailwala та Terry P. Yamaguchi. "Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription". Proceedings of the National Academy of Sciences 113, № 13 (2016): 3545–50. http://dx.doi.org/10.1073/pnas.1519994113.

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The ancient, highly conserved, Wnt signaling pathway regulates cell fate in all metazoans. We have previously shown that combined null mutations of the specificity protein (Sp) 1/Klf-like zinc-finger transcription factors Sp5 and Sp8 (i.e., Sp5/8) result in an embryonic phenotype identical to that observed when core components of the Wnt/β-catenin pathway are mutated; however, their role in Wnt signal transduction is unknown. Here, we show in mouse embryos and differentiating embryonic stem cells that Sp5/8 are gene-specific transcriptional coactivators in the Wnt/β-catenin pathway. Sp5/8 bind

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Hu, Jie Hong, Patrick Navas, Hua Cao, George Stamatoyannopoulos, and Chao-Zhong Song. "Systematic RNAi Studies on the Role of Sp/KLF Factors in Globin Gene Expression and Erythroid Differentiation." Journal of Molecular Biology 366, no. 4 (2007): 1064–73. http://dx.doi.org/10.1016/j.jmb.2006.12.047.

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Alpy, Fabien, Anne Boulay, Christel Moog-Lutz, et al. "Metastatic lymph node 64 (MLN64), a gene overexpressed in breast cancers, is regulated by Sp/KLF transcription factors." Oncogene 22, no. 24 (2003): 3770–80. http://dx.doi.org/10.1038/sj.onc.1206500.

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Sharma, Archna, Qinghua Chen, Trang Nguyen, Qing Yu, and Jyoti Sen. "T Cell Factor-1 and beta-catenin regulate the development of memory-like CD8 thymocytes (110.6)." Journal of Immunology 188, no. 1_Supplement (2012): 110.6. http://dx.doi.org/10.4049/jimmunol.188.supp.110.6.

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Abstract In addition to conventional alpha-beta T cells, recent studies have demonstrated the presence of a subset of CD8 single positive (SP) mature thymocytes, referred to as memory-like or innate-like thymocytes that acquire effector functions in the thymus as a result of the maturation process. These cells have been described in mice with mutations in KLF2, Itk, CBP genes and SLAM family members and in non-mutant Balb/c mice in response to IL-4 produced by thymocytes. Here, we demonstrate that enhanced function of transcription factors T Cell Factor (TCF)-1 and beta-catenin regulate the fr

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Truty, M. J., M. E. Fernandez-Zapico, and R. Urrutia. "COMPREHENSIVE ANALYSIS OF THE SP/KLF FAMILY OF TRANSCRIPTION FACTORS IN THE TGF-BETA SIGNALING IN PANCREATIC CANCER CELLS." Pancreas 31, no. 4 (2005): 474. http://dx.doi.org/10.1097/01.mpa.0000193781.42217.51.

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Daftary, Gaurang S., Gwen A. Lomberk, Navtej S. Buttar, et al. "Detailed Structural-Functional Analysis of the Krüppel-like Factor 16 (KLF16) Transcription Factor Reveals Novel Mechanisms for Silencing Sp/KLF Sites Involved in Metabolism and Endocrinology." Journal of Biological Chemistry 287, no. 10 (2011): 7010–25. http://dx.doi.org/10.1074/jbc.m111.266007.

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Zheng, Ye, Zaid M. Tabbaa, Zaraq Khan, et al. "Epigenetic Regulation of Uterine Biology by Transcription Factor KLF11 via Posttranslational Histone Deacetylation of Cytochrome p450 Metabolic Enzymes." Endocrinology 155, no. 11 (2014): 4507–20. http://dx.doi.org/10.1210/en.2014-1139.

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Abstract Endocrine regulation of uterine biology is critical for embryo receptivity and human reproduction. Uterine endometrium depends on extrinsic sex steroid input and hence likely has mechanisms that enable adaptation to hormonal variation. Emerging evidence suggests that sex steroid bioavailability in the endometrium is determined by adjusting their metabolic rate and fate via regulation of cytochrome (CYP) p450 enzymes. The CYP enzymes are targeted by ubiquitously expressed Sp/Krüppel-like (Sp/KLF) transcription factors. Specifically, KLF11 is highly expressed in reproductive tissues, re

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Utami, Trianna W., Keiko Miyoshi, Hiroko Hagita, Ryna Dwi Yanuaryska, Taigo Horiguchi, and Takafumi Noma. "Possible Linkage of SP6 Transcriptional Activity with Amelogenesis by Protein Stabilization." Journal of Biomedicine and Biotechnology 2011 (2011): 1–10. http://dx.doi.org/10.1155/2011/320987.

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Ameloblasts produce enamel matrix proteins such as amelogenin, ameloblastin, and amelotin during tooth development. The molecular mechanisms of ameloblast differentiation (amelogenesis) are currently not well understood. SP6 is a transcription factor of the Sp/KLF family that was recently found to regulate cell proliferation in a cell-type-specific manner.Sp6-deficient mice demonstrate characteristic tooth anomalies such as delayed eruption of the incisors and supernumerary teeth with disorganized amelogenesis. However, it remains unclear howSp6controls amelogenesis. In this study, we used SP6

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Setton, Emily V. W., and Prashant P. Sharma. "Cooption of an appendage-patterning gene cassette in the head segmentation of arachnids." Proceedings of the National Academy of Sciences 115, no. 15 (2018): E3491—E3500. http://dx.doi.org/10.1073/pnas.1720193115.

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The jointed appendages of arthropods have facilitated the spectacular diversity and success of this phylum. Key to the regulation of appendage outgrowth is the Krüppel-like factor (KLF)/specificity protein (Sp) family of zinc finger transcription factors. In the fruit fly, Drosophila melanogaster, the Sp6-9 homolog is activated by Wnt-1/wingless (wg) and establishes ventral appendage (leg) fate. Subsequently, Sp6-9 maintains expression of the axial patterning gene Distal-less (Dll), which promotes limb outgrowth. Intriguingly, in spiders, Dll has been reported to have a derived role as a segme

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van Ouwerkerk, Antoinette F., Fernanda M. Bosada, Karel van Duijvenboden, et al. "Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction." Circulation 145, no. 8 (2022): 606–19. http://dx.doi.org/10.1161/circulationaha.121.054347.

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Background: The pathogenic missense variant p.G125R in TBX5 (T-box transcription factor 5) causes Holt–Oram syndrome (also known as hand–heart syndrome) and early onset of atrial fibrillation. Revealing how an altered key developmental transcription factor modulates cardiac physiology in vivo will provide unique insights into the mechanisms underlying atrial fibrillation in these patients. Methods: We analyzed ECGs of an extended family pedigree of Holt–Oram syndrome patients. Next, we introduced the TBX5-p.G125R variant in the mouse genome ( Tbx5 G125R ) and performed electrophysiologic analy

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Zhang, Yachao, Jieqiong Yang, Shijian Lv, et al. "Downregulation of decidual SP1 and P300 is associated with severe preeclampsia." Journal of Molecular Endocrinology 60, no. 2 (2018): 133–43. http://dx.doi.org/10.1530/jme-17-0180.

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Preeclampsia (PE) is a pregnancy-induced disorder characterized by hypertension and proteinuria after 20 weeks of gestation, affecting 5–7% of pregnancies worldwide. So far, the etiology of PE remains poorly understood. Abnormal decidualization is thought to contribute to the development of PE. SP1 belongs to the Sp/KLF superfamily and can recruit P300 to regulate the transcription of several genes. SP1 is also very important for decidualization as it enhances the expression of tissue factor. In this study, we investigated the expression of SP1 and P300 in deciduae and their relationship with

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Nishimura, Toshinobu, Shin Kaneko, Yoko Tajima, et al. "In Vitro Generation of Mature T Lymphocytes From Human Ips Cells and Genetic Analysis of TCR Gene Rearrangements." Blood 118, no. 21 (2011): 2984. http://dx.doi.org/10.1182/blood.v118.21.2984.2984.

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Abstract Abstract 2984 T lymphocytes play central roles in cellular immunity, exerting their proliferative and effector activities when they recognize antigens via T-cell receptors (TCRs) in HLA-restricted and antigen-specific manner. Adoptive cell transfer therapy (ACT), the administration of ex vivo-activated and -expanded autologous tumor-reactive T lymphocytes, is currently one of the effective methods for immunotherapy, especially for treatment of metastatic solid tumors including melanoma. However, the successful applications of this method are currently limited for tumor therapies. To b

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Lin, Kuanyin Karen, Lara Rossi, and Margaret A. Goodell. "CD81 Is Essential for HSC Self-Renewal through Suppressing Proliferation." Blood 112, no. 11 (2008): 76. http://dx.doi.org/10.1182/blood.v112.11.76.76.

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Abstract Hematopoietic stem cells (HSCs) comprise only ~0.02% of the whole bone marrow cells but possess the capacity to extensively proliferate in order to restore hematopoietic homeostasis. Under homeostasis, HSCs are relatively quiescent with a slow cell cycle progression rate. However, upon stimulation, HSCs are able to promptly proliferate and undergo self-renewal to regenerate HSCs as daughter cells. While regulatory mechanisms involved in cell cycle progression are well characterized to be essential for HSC self-renewal, the mechanisms that facilitate the return of proliferating HSC to

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Hu, Kang, Qing-Kang Zheng, Rui-Jie Ma, Chao Ma, Zhi-Gang Sun, and Nan Zhang. "Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors." Frontiers in Cell and Developmental Biology 9 (March 18, 2021). http://dx.doi.org/10.3389/fcell.2021.661731.

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Krüppel-like factor 6 (KLF6) is one of the most studied members of the specificity protein/Krüppel-like factor (SP/KLF) transcription factor family. It has a typical zinc finger structure and plays a pivotal role in regulating the biological processes of cells. Recently, it has been considered to play a role in combatting cancer. Krüppel-like factor 6 splice variant 1 (KLF6-SV1), being one of the alternative KLF6 splicing isoforms, participates in tumor occurrence and development and has the potential to become a new target for molecular targeted therapy, although its action mechanism remains

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Helbing, Thomas, Jennifer Heinke, Franziska Volkmar, et al. "Abstract 403: BMPER Is an Angiogenic Modulator that is Regulated by KLF-15 and FoxO3A and Controls Bone Morphogentic Protein Activity." Circulation 118, suppl_18 (2008). http://dx.doi.org/10.1161/circ.118.suppl_18.s_298.

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BMPER (bone morphogenetic protein [BMP] endothelial precursor cell derived regulator) is an extracellular protein, that interacts with BMPs and thereby modulates BMP dependent vasculogenesis and angiogenesis. Our previous observations suggest a complex regulation of BMPER expression. During embryogenesis BMPER is expressed at the time and at sites of vasculogenesis, whereas in the adult organism it is expressed in heart, lung and skin. Methods and Results: We have cloned the mouse BMPER promoter and appropriate deletion constructs into pGL3 to regulate luciferase expression. As predicted in si

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Meng, Guoliang, Liping Xie, and Yong Ji. "Abstract 72: Hydrogen Sulfide Prevents Myocardial Hypertrophy in a Klf5-dependent Manner." Circulation Research 117, suppl_1 (2015). http://dx.doi.org/10.1161/res.117.suppl_1.72.

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Rationale: H 2 S is a gasotransmitter that regulates multiple cardiovascular functions. Krüppel-like transcription factor (KLF) exerts diverse functions in the cardiovascular system. Objectives: The aim of present study was to investigate the effect of hydrogen sulfide (H 2 S) on myocardial hypertrophy. Methods and results: Myocardial samples of 22 patients with left ventricle hypertrophy were collected and underwent histological and molecular biological analysis. Spontaneously hypertensive rats (SHR) and neonatal rat cardiomyocytes were studied for functional and signaling response to GYY4137

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Schmidt, Arne, Maximilian Fuchs, Stevan D. Stojanović, et al. "Deciphering Pro-angiogenic Transcription Factor Profiles in Hypoxic Human Endothelial Cells by Combined Bioinformatics and in vitro Modeling." Frontiers in Cardiovascular Medicine 9 (June 17, 2022). http://dx.doi.org/10.3389/fcvm.2022.877450.

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BackgroundConstant supply of oxygen is crucial for multicellular tissue homeostasis and energy metabolism in cardiac tissue. As a first response to acute hypoxia, endothelial cells (ECs) promote recruitment and adherence of immune cells to the dysbalanced EC barrier by releasing inflammatory mediators and growth factors, whereas chronic hypoxia leads to the activation of a transcription factor (TF) battery, that potently induces expression of growth factors and cytokines including platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). We report a hypoxia-minded, t

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Finco, Timothy Scott, Victoria E. Hamilton, Shivani J. Patel, Cindy Zheng, and Geri E. Justice. "Regulation of the human LAT gene by Ets and Sp/KLF transcription factors." FASEB Journal 20, no. 4 (2006). http://dx.doi.org/10.1096/fasebj.20.4.a82-a.

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Ilsley, Melissa D., Stephen Huang, Graham W. Magor, Michael J. Landsberg, Kevin R. Gillinder, and Andrew C. Perkins. "Corrupted DNA-binding specificity and ectopic transcription underpin dominant neomorphic mutations in KLF/SP transcription factors." BMC Genomics 20, no. 1 (2019). http://dx.doi.org/10.1186/s12864-019-5805-z.

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mukund, kavitha, and Shankar Subramaniam. "Signed Differential Co‐Expression Network Analysis Suggests Differential Regulation of SP/KLF Family of Transcription Factors in Dilated Cardiomyopathy." FASEB Journal 32, S1 (2018). http://dx.doi.org/10.1096/fasebj.2018.32.1_supplement.803.5.

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Gura, Megan A., Soňa Relovská, Kimberly M. Abt, et al. "TAF4b transcription networks regulating early oocyte differentiation." Development 149, no. 3 (2022). http://dx.doi.org/10.1242/dev.200074.

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ABSTRACT Establishment of a healthy ovarian reserve is contingent upon numerous regulatory pathways during embryogenesis. Previously, mice lacking TBP-associated factor 4b (Taf4b) were shown to exhibit a diminished ovarian reserve. However, potential oocyte-intrinsic functions of TAF4b have not been examined. Here, we use a combination of gene expression profiling and chromatin mapping to characterize TAF4b-dependent gene regulatory networks in mouse oocytes. We find that Taf4b-deficient oocytes display inappropriate expression of meiotic, chromatin modification/organization, and X-linked gene

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Houser, Josef, Kristina Jendruchova, Andrea Knight, and Martin Piskacek. "The NFkB activation domain is 14-amino-acid-long variant of the 9aaTAD." Biochemical Journal, February 24, 2023. http://dx.doi.org/10.1042/bcj20220605.

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The nine-amino-acid TransActivation Domains (9aaTAD) was identified in numerous transcription factors including Gal4, p53, E2A, MLL, c-Myc, N-Myc, and also in SP, KLF and SOX families. Most of the 9aaTAD domains interact with the KIX domain of transcription mediators MED15 and CBP to activate transcription. The NFkB activation domain occupied the same position on the KIX domain as the 9aaTADs of MLL, E2A and p53. Binding of the KIX domain is established by the two-point interaction involving 9aaTAD positions p3-4 and p6-7. The NFkB primary binding region (position p3-4) is almost identical to

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Koike, Nobuyuki, Jun Sugimoto, Motonori Okabe, et al. "Distribution of Amniotic Stem Cells in Human Term Amnion Membrane." Microscopy, September 18, 2021. http://dx.doi.org/10.1093/jmicro/dfab035.

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Abstract Amnion membrane studies related to miscarriage have been conducted in the field of obstetrics and gynecology. However, the distribution of stem cells within the amnion, and the differences in the properties of each type of stem cells are still not well understood. We address this gap in knowledge in the present study where we morphologically classified, the amnion membrane, and we clarified the distribution of stem cells here to identify functionally different amniotic membrane-derived stem cells. The amnion is composed of the chorion frondosum region [umbilical cord -adjacent amnion

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Lu, Tianyuan, and Jessica C. Mar. "Investigating transcriptome-wide sex dimorphism by multi-level analysis of single-cell RNA sequencing data in ten mouse cell types." Biology of Sex Differences 11, no. 1 (2020). http://dx.doi.org/10.1186/s13293-020-00335-2.

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Abstract Background It is a long established fact that sex is an important factor that influences the transcriptional regulatory processes of an organism. However, understanding sex-based differences in gene expression has been limited because existing studies typically sequence and analyze bulk tissue from female or male individuals. Such analyses average cell-specific gene expression levels where cell-to-cell variation can easily be concealed. We therefore sought to utilize data generated by the rapidly developing single cell RNA sequencing (scRNA-seq) technology to explore sex dimorphism an

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