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Thèses sur le sujet « Spinal cord Sex role »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 13 février 2022

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1

Norrbrink, Budh Cecilia. "Pain following spinal cord injury /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-995-1/.

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2

Gray, de Cristoforis Angelica [Verfasser], and Tanja [Akademischer Betreuer] Vogel. "Role of DOT1L in spinal cord formation." Freiburg : Universität, 2021. http://d-nb.info/1238016545/34.

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3

Little, Janine Monique. "Spinal cord processing of cardiac nociception are there sex differences? /." Oklahoma City : [s.n.], 2010.

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4

Glasgow, Stacey Marie. "The role of PTF1A in spinal cord development." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=155.

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5

Sahinkaya, Fatma Rezan. "The Role of Intraspinal Hemorrhage in Spinal Cord Injury." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1414437916.

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6

López, Serrano Clara. "Role of lysophosphatidic acid receptors in spinal cord injury physiopathology." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/458682.

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La médula espinal, la cual constituye una parte vital para el sistema nervioso central (SNC), puede resultar dañada a pesar de estar muy bien protegida por la columna vertebral, dando lugar a importantes consecuencias. La lesión medular provoca una alteración de las redes neuronales que están involucradas en diversas funciones fisiológicas. De hecho, dado que los axones del SNC de mamíferos adultos no pueden regenerarse tras una lesión, y que las células dañadas no pueden ser reparadas, esta patología viene acompañada de una pérdida funcional irreversible para los pacientes afectados. La fisi

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7

Perry, Sharn. "Deciphering the Locomotor Network : The Role of Spinal Cord Interneurons." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-305601.

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In the spinal cord, an intricate neural network generates and coordinates the patterning of limb movements during locomotion. This network, known as the locomotor central pattern generator (CPG), comprises of various cell populations that together orchestrate the output of motor neurons. Identification of CPG neurons through their specific gene expression is a valuable tool that can provide considerable insight to the character, intrinsic properties and role of a population, which represents a step toward understanding locomotor circuit function and correlating neural activity to behaviour. We

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8

Rottkamp, Catherine Anne-Marie. "The Role of Hox Cofactors in Vertebrate Spinal Cord Development." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1194575822.

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9

Fabes, J. "Investigating the role of ephrin signalling in spinal cord injury." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445432/.

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Spinal cord injury in adult mammals commonly leads to the permanent loss of motor and sensory function in regions of the body below the level of injury. The inability of the central nervous system to regenerate is, in part, due to the presence of growth-inhibitory agents surrounding the lesion site. This thesis presents a previously unreported, inhibitory interaction between ephrinB2 expressed on reactive astrocytes and the EphA4 receptor present on lesioned corticospinal tract axons. This interaction appears to mediate the unusually large retraction of the corticospinal tract away from spinal

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10

Restrepo, Arboleda Carlos Ernesto. "Neurotransmitter phenotypes of neurons in the spinal cord and their functional role in the mouse locomotor network." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-833-4/.

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11

Washburn, Stephanie Nicole. "Role of the opioid system in the behavioral deficit observed after uncontrollable shock." Texas A&M University, 2003. http://hdl.handle.net/1969.1/3993.

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Spinal cord neurons can support a simple form of instrumental learning that can be used to assess behavioral potential (plasticity) within this system. In this paradigm, subjects completely transected at the second thoracic vertebra learn to minimize shock exposure by maintaining a hindlimb in a flexed position. Preexposure to uncontrollable shock (shock independent of leg position) disrupts this learning. Activation of opioid receptors seems to contribute to the expression of the behavioral deficit observed after uncontrollable shock. Intrathecal application of naltrexone, a nonselective opio

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12

Urch, Catherine. "Post-natal development of nociceptive transmission : the role of the NMDA receptor complex." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270184.

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13

Johansson, Martin M. "The Human Y chromosome and its role in the developing male nervous system." Doctoral thesis, Uppsala universitet, Institutionen för organismbiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-261789.

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Recent research demonstrated that besides a role in sex determination and male fertility, the Y chromosome is involved in additional functions including prostate cancer, sex-specific effects on the brain and behaviour, graft-versus-host disease, nociception, aggression and autoimmune diseases. The results presented in this thesis include an analysis of sex-biased genes encoded on the X and Y chromosomes of rodents. Expression data from six different somatic tissues was analyzed and we found that the X chromosome is enriched in female biased genes and depleted of male biased ones. The second st

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14

Xiong, Yiqin. "ROLE OF REACTIVE OXYGEN SPECIES PEROXYNITRITE IN TRAUMATIC SPINAL CORD INJURY." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/657.

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Peroxynitrite (PN, ONOO-), formed by nitric oxide radical (•NO) and superoxide radical (O2•-), plays an important role in post-traumatic oxidative damage. In the early work, we determined the temporal characteristics of PN-derived oxidative damage in a rat spinal cord injury (SCI) model. Our results showed 3-nitrotyrosine (3-NT), a specific marker for PN, rapidly accumulated at early time points (1 hr, 3 hrs), after when it plateaued and the high level was sustained to 1 week post injury. The co-localization of 3-NT and lipid peroxidation derived-4-HNE observed in immunohistochemistry indicat

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15

Clark, Jordan Mills. "ROLE OF CYCLOPHILIN D IN SECONDARY SPINAL CORD AND BRAIN INJURY." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/730.

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In the hours and days following acute CNS injury, a secondary wave of events is initiated that exacerbate spinal tissue damage and neuronal cell death. A potential mechanism driving these secondary events is opening of the mitochondrial permeability transition pore (mPTP) and subsequent release of several cell death proteins. Previous studies have shown that inhibition of cyclophilin D(CypD), the key regulating component in mPTP opening, was protective against insults that induce necrotic cell death. We therefore hypothesized that CypD-null mice would show improved functional and pathological

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16

Rigato, Chiara. "Role of microglial cells during the mouse embryonic spinal cord development." Paris 6, 2013. http://www.theses.fr/2013PA066326.

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Le but de mon projet de thèse a été d’investiguer le rôle des cellules microgliales in vivo au cours du développement. On s’est particulièrement intéressés au développement de la moelle épinière car ce modèle a été bien caractérisé. Nous avons trouvé que les microglies colonisent la moelle épinière embryonnaire grâce à leur migration et prolifération. A E12. 5 les microglies s’accumulent transitoirement au point d’insertion des ganglions de la racine dorsale et phagocytent les axons apoptotiques des neurones sensoriels. A E13. 5 les microglies interagissent avec les glies radiaires, expriment

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17

Almad, Akshata A. "Role Of PPAR Family Of Transcription Factors In Spinal Cord Injury." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1292952253.

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18

Lang, Bradley Thomas. "THE ROLE OF PTPs IN REGENERATION FAILURE FOLLOWING SPINAL CORD INJURY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1417619755.

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19

Santos, Nogueira Eva. "Spinal cord injury: Role of endothelial differentiation gene family lysophosphatidic acid receptors." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/285416.

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El daño tisular secundario que se produce tras una lesión de la médula espinal contribuye de manera significativa a las pérdidas funcionales que se observan pacientes que padecen este tipo de afectación. Aunque la regeneración axonal y la sustitución de las neuronas dañadas tras el traumatismo medular son objetivos importantes para reparar estas lesiones, el desarrollo de estrategias experimentales que tengan como meta evitar el daño secundario sobre axones, neuronas, mielina y las células gliales, sea probablemente más factible de conseguir. La respuesta inflamatoria que se produce después d

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20

Al, Ghamdi Kholoud Saad. "Populations of spinal cord dorsal horn neurons and their role in nociception." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3425/.

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Nociception involves detection of tissue damage by specialized receptors; nociceptors. These convey information to the first synaptic relays in the dorsal horn of the spinal cord. Within the dorsal horn itself are the dorsal horn neurons which can be divided into two broad classes, based on their axonal projections: projection neurons and interneurons. The neurokinin 1 receptor (NK1r), the main target for substance P, is expressed by most projection neurons and many interneurons in the dorsal horn. These NK1r-expressing neurons show a bimodal size distribution in lamina I. The 1st part of the

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21

Wilson, Leigh Jane. "The role of retinoids in dorso-ventral patterning of the spinal cord." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404894.

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22

Washburn, Stephanie Nicole. "The role of stress in recovery of function after spinal cord injury." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1607.

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23

Hesp, Zoe Ciambro. "The Role of NG2+ Cells in Endogenous Repair after Spinal Cord Injury." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487785833325771.

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24

Filous, Angela R. Ph D. "The Role of NG2+ Cells in Regeneration Failure After Spinal Cord Injury." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1396605992.

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25

Maloney, Jessica K. "Role of activated microglia in spinal cord plasticity following peripheral axon injury." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1501146935183192.

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26

Velázquez, Ulloa Norma Andrea. "Mechanism for Spontaneous Calcium Activity and Spinal Cord Neurotransmitter Specification, and the Role of Calcium Activity in Dopamine Specification in the Brain and Spinal Cord." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3369539.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed September 15, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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27

Dasgupta, Prokar. "Towards an understanding of the role of the intravesical capsaicin in the treatment of detrusor hyperreflexia." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368709.

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28

Rottkamp, Catherine Anne-Marie. "The role of Hox cofactors in vertebrate spinal coed development." Cleveland, Ohio : Case Western Reserve University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1194575822.

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29

Redensek, Adriana. "The role of prostaglandin D2 as an inflammatory mediator following spinal cord injury." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66832.

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Spinal cord injury affects thousands of people every year, however, treatment options are currently limited and none are universally accepted. Inflammation has been shown to play a critical role in propagating secondary damage which exacerbates the initial trauma, therefore modulating the inflammatory response after injury has therapeutic potential. As prostaglandins are powerful inflammatory mediators in the periphery, I have examined the role of prostaglandin D2 (PGD2) after spinal cord injury. My thesis provides evidence that PGD2 produced from hematopoietic prostaglandin

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30

Ali, Alima Shahin. "Investigation into the role of the spinal cord in the control of posture." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403929.

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31

Schertenleib, Denis. "The role of retinoid receptors in the development of the mouse spinal cord." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314089.

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32

Bellver, Landete Victor. "The role of microglia in spinal cord injury : identification, importance and therapeutic implications." Doctoral thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/40163.

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33

Horn, Kevin Paul. "An Investigation of the Role of Macrophages in Spinal Cord Injury and Repair." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1249267954.

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34

Bautista, Guzman Wendy Diana. "Role of electrical and mixed synapses in the modulation of spinal cord sensory reflexes." Journal of Physiology, 2012. http://hdl.handle.net/1993/22190.

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The first part of my thesis involves an investigation into mechanisms underlying the presynaptic regulation of transmitter release from myelinated hindlimb sensory afferents in rodents. The central hypothesis is that in addition to chemical transmission in spinal neuronal networks, electrical synapses formed by connexins are critically involved in presynaptic inhibition of large diameter sensory afferents. Subsequent sections of the thesis present a detailed examination of the distribution of connexins in the rodent spinal cord with a particular emphasis on the neuronal connexin, Cx36. Conn

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35

Prasad, Tuhina Weiner Joshua A. "The role of gamma-protocadherins in interneuron survival and circuit formation in the developing spinal cord." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/423.

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36

Kunzmann, Richard. "The self-concept of spinally-injured people : the role of frequent internet communication within cyber-communities." Pretoria : [s.n.], 2002. http://upetd.up.ac.za/thesis/available/etd-10132005-122701/.

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37

Ripat, Jacqueline Dawn. "Self-perceived participation amongst adults with spinal cord injuries: the role of assistive technology." Informa HealthCare, 2011. http://hdl.handle.net/1993/4923.

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The purpose of this research was to develop a theoretical understanding of the influences on participation for individuals with spinal cord injury (SCI) from a self-perceived perspective, with particular focus on the role of assistive technology (AT) in self-perceived participation. The theoretical underpinning, symbolic interactionism, was used to gain an understanding of the ways that adults with SCI ascribe meaning to the interaction between themselves and their unique environments in a process of participation. A grounded theory study of 19 adults with SCI was conducted. Participants eng

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38

Noor, Nor Farid Mohd. "Cerebrospinal fluid contacting cells in the spinal cord : characteristics and potential role in neurogenesis." Thesis, University of Leeds, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634212.

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In the spinal cord Lamina X, Cerebrospinal Fluid contacting Cells (CSFcCs) are located in between and immediately adjacent to the ependymal cells surrounding the central canal. Little is known about the function of the CSFcCs. This thesis investigates potential functions for CSFcCs and suggests a potential involvement in the proliferation of cells surrounding the central canal. CSFcCs have previously been shown to express markers consistent with them being immature neurones. The hypothesis that they can be generated in adult postnatal spinal cord was tested. Using Glutamic Acid Decarboxylase 6

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39

Mysiak, Karolina Sandra. "The role of monoamines in the development and regeneration of the zebrafish spinal cord." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25855.

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The hallmark of an adult mammalian central nervous system is the inability to regenerate after an injury. Zebrafish, on the other hand, have an astounding regenerative capacity. After a spinal cord lesion, zebrafish can re-establish the damaged neuronal network and regain their swimming ability within weeks. This is partly due to the presence of the ependymal radial glia (ERGs), which line the wall of the central canal and act as the stem/progenitor cells of the spinal cord. Under homeostatic conditions the ERGs are largely quiescent, however, the lesion triggers them to proliferate and replac

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40

Fuller, Molly Lynn. "The Role of Bone Morphogenetic Proteins in Reactive Gliosis after Demyelinating Spinal Cord Lesions." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1183990990.

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41

Kigerl, Kristina Ann. "Role of the innate immune response and toll-like receptors following spinal cord injury in the mouse." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164213220.

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42

Chilton, John K. "The role of receptor protein tyrosine phosphatases in axon guidance." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365814.

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43

Garner, Ashley Nicole. "The Role of Injury-related Injustice Perception in Adjustment to Spinal Cord Injury: an Exploratory Analysis." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822837/.

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Research has begun to explore the presence and role of health-related injustice perceptions in samples of individuals who experience chronic pain associated with traumatic injury. Existing studies indicate that higher level of injustice perception is associated with poorer physical and psychosocial outcomes. However, to date, few clinical populations have been addressed. The aim of the current study was to explore injustice perceptions in a sample of individuals who have sustained a spinal cord injury (SCI), as research suggests that such individuals are likely to experience cognitive elements

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44

Kettunen, Petronella. "Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-079-6/.

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45

Dalton, Dustin. "Assessing the Role of Polyethylene Glycol (PEG) in Improving Functional Recovery Following Spinal Cord Injury." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2543.

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Injury to the spinal cord results in the disruption of signal transmission between the brain and distal targets. It often presents with the loss of motor function and sensory perception below the level of injury. There are many obstacles following injury that must be overcome in order to encourage axon regeneration and improve functional recovery. A combinatorial approach is necessary to combat physical and chemical barriers to recovery. The fluid filled cyst that forms in the majority of spinal cord injuries presents a physical barrier that we treat with our electrospun bridges. We impla

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46

Goodman, Keiser Melanie Dawn. "Postsynaptic dorsal column spinal pathway does it play a role in cardiac pain? /." Oklahoma City : [s.n.], 2009.

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47

David, Mónica Delia. "Differentiation of spinal cord neural precursors and hippocampal neurons: a role for Wnt and β-catenin." Doctoral thesis, Universitat de Lleida, 2009. http://hdl.handle.net/10803/8095.

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Per al correcte desenvolupament del sistema nerviós cal una precisa coordinació entre la neurogènesi i la morfogènesi neuronal. L'exposició de les cèl·lules neurals progenitores a un seguit de senyals específiques de l´entorn, que regulen la seva proliferació i especificació, donarà lloc a les neurones. Les neurones recent formades comencen a extendre processos neuronals fins a formar una complexa estructura arborescent; durant aquesta etapa es formen les sinapsis entre els axons i les dendrites, i s'estableix una xarxa cerebral funcional. Entre els factors extracel·lulars que controlen aquest

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Chun, Sanghee. "The role of leisure in the experience of posttraumatic growth for people with spinal cord injury." [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3274278.

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Thesis (Ph.D.)--Indiana University, School of Health, Physical Education and Recreation, 2007.<br>Source: Dissertation Abstracts International, Volume: 68-07, Section: B, page: 4424. Adviser: Youngkhill Lee. Title from dissertation home page (viewed Apr. 21, 2008).

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Peter, Claudio [Verfasser], and Alarcos [Akademischer Betreuer] Cieza. "Adjustment to spinal cord injury (SCI) : the role of psychological resources / Claudio Peter. Betreuer: Alarcos Cieza." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1043906665/34.

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50

Prasad, Tuhina. "The role of gamma-protocadherins in interneuron survival and circuit formation in the developing spinal cord." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/423.

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Protocadherins (Pcdhs) are a large family of adhesion molecules which have structure similar to that of classical cadherins. About 60 Pcdh genes are organized into three clusters (-á,- â and- ã), which are arranged contiguously on a single chromosome in mammals. Mice in which the 22-gene Pcdh- ã locus has been deleted die within a few hours of birth and show defects in movement and reflexes, extensive neurodegeneration in the spinal cord, and loss of synapses. Further studies have shown that loss of ã-Pcdhs has a primary effect on the formation or maintenance of synapses that can be dissociate

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