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Thèses sur le sujet « Stromal tissue »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Moreau, Jodie E. "Stimulation of bone marrow stromal cells in the development of tissue engineered ligaments /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2005.

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Thesis (Ph.D.)--Tufts University, 2005.<br>Adviser: Gregory H. Altman. Submitted to the Dept. of Biology--Biotechnology. Includes bibliographical references (leaves 183-192). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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2

Krasheninnikova, Maria Alieva. "Adipose tissue mesenchymal stromal cells as therapeutic vehicles against glioblastoma." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/97086.

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Lately adipose tissue mesenchymal stem cells (hAMSCs) have emerged as cellular vehicles for therapy of solid tumors, due to their ease of isolation and manipulation, and wound/tumor homing capacity. HAMSCs have been successfully used in suicide gene therapy, employing the prodrug activating system based on Herpes simplex virus type I thymidine kinase (HSV-TK)/ganciclovir (GCV). In the current study we demonstrate an effective model of glioblastoma therapy based on the use of genetically modified hAMSCs and in vivo monitoring of tumor and therapeutic cells. Due to the capacity of photons to pa

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3

Gronthos, Stan. "Stromal precursor cells : purification and the development of bone tissue." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phg8757.pdf.

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Bibliography: leaves 152-223. Experiments were designed to identify and purify human bone marrow stromal precursor cells by positive immunoselection, based on the cell surface expression of the VCAM-1 and STRO-1 antigens. The data presented demonstrates a hierarchy of bone cell development in vitro.

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Yoshida, Atsuhiro. "Adipose Tissue-Derived Stromal Cells Protect Hair Cells From Aminoglycoside." Kyoto University, 2012. http://hdl.handle.net/2433/157458.

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Bray, Laura Jane. "Evaluation of fibroin-based scaffolds for ocular tissue reconstruction." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/52665/1/Laura_Bray_Thesis.pdf.

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The epithelium of the corneolimbus contains stem cells for regenerating the corneal epithelium. Diseases and injuries affecting the limbus can lead to a condition known as limbal stem cell deficiency (LSCD), which results in loss of the corneal epithelium, and subsequent chronic inflammation and scarring of the ocular surface. Advances in the treatment of LSCD have been achieved through use of cultured human limbal epithelial (HLE) grafts to restore epithelial stem cells of the ocular surface. These epithelial grafts are usually produced by the ex vivo expansion of HLE cells on human donor amn

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Vivas, Pradillo Daniel. "Optimisation of a Tissue Engineering Product based on Mesenchymal Stromal Cells aiming to regenerate bony tissue." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/664844.

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Bone is a highly organised and specialised connective tissue that provides a rigid, protective and supporting framework to the body. In addition to this, bone is unique in its capacity to self-regenerate without the formation of a fibrotic scar. Despite its natural healing potential, bone is not always able to repair large defects, which can result in permanent bone loss and fracture non-unions. Consequently, interventions such as bone grafting are required to replace damaged or diseased bone, accounting for more than two million grafted bones in the world annually. Currently, autografts are

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Cheung, Iris Ka-Man. "Modulation of connective tissue stromal cell plasticity to generate cartilaginous phenotypes." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54933/.

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Stem cells are unspecialised cells found in the body which possess the ability to self renew and can be induced to proliferate and differentiate into more specialised cells. MSCs are adult stem cells that are capable of leaving the bone marrow and travelling in the bloodstream to a different site, where they may perform repair or regeneration processes of various mesenchymal tissues such as cartilage, bone and fat. Due to these properties of MSCs, it proves to be a useful source for the repair and regeneration of cartilage. The aims of this study were to: 1) characterise primary bovine MSCs by

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Bittira, Bindu. "Bone marrow stromal cells in the tissue repair process following myocardial infarction." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32763.

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Marrow stromal cells (MSCs) are pluripotent stem cells which may participate in the repair of damaged organs. We tested the hypothesis that MSCs can be recruited to the heart upon myocardial infarction, and play pathophysiological roles in the subsequent healing and adaptation process. An animal model was created with labeled MSCs in its bone marrow and then a myocardial infarction produced. Donor MSCs from isogenic Lewis rats were harvested, multiplied in culture and labelled. Labelled cells were intravenously injected into the recipient rats and one week later upon the engraftment of these l

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Lieb, Esther. "Bone tissue engineering from marrow stromal cells : effects of growth factors and biomaterials." kostenfrei, 2004. http://www.opus-bayern.de/uni-regensburg/volltexte/2004/312/.

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Dominek, Piotr. ""The Role of Human Tissue Kallikrein in the Pathogenesis of Gastrointestinal Stromal Tumours"." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526053.

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11

Mauney, Joshua R. "Osteogenic differentiation of bone marrow stromal cells : implications to bone tissue engineering strategies /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2004.

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Thesis (Ph.D.)--Tufts University, 2004.<br>Adviser: David L. Kaplan. Submitted to the Dept. of Biotechnology Engineering. Includes bibliographical references (leaves 162-222). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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12

Kreke, Michelle Renee. "Application of Fluid Flow for Functional Tissue Engineering of Bone Marrow Stromal Cells." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/27321.

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In the United States, nearly half a million bone graft operations are performed annually to repair defects arising from birth defects, trauma, and disease, making bone the second most transplanted tissue. Autogenous bone is the current gold standard for bone grafts; however it is in limited supply and results in a second injury at the donor site. A promising alternative is a tissue engineered bone graft composed of a biomaterial scaffold, pharmaceutics, and osteoprogenitor cells. One source of osteoprogenitor cells is bone marrow stroma, which can be obtained from the patient - minimizing th

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Ferng, Alice S., Katherine M. Marsh, Jamie M. Fleming, et al. "Adipose-derived human stem/stromal cells: comparative organ specific mitochondrial bioenergy profiles." SPRINGER INTERNATIONAL PUBLISHING AG, 2016. http://hdl.handle.net/10150/622736.

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Background: Adipose-derived stem/stromal cells (ASCs) isolated from the stromal vascular fraction are a source of mesenchymal stem cells that have been shown to be beneficial in many regenerative medicine applications. ASCs are an attractive source of stem cells in particular, due to their lack of immunogenicity. This study examines differences between mitochondrial bioenergetic profiles of ASCs isolated from adipose tissue of five peri-organ regions: pericardial, thymic, knee, shoulder, and abdomen. Results: Flow cytometry showed that the majority of each ASC population isolated from the adip

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Nakada, Akira. "Regeneration of central nervous tissue using a collagen scaffold and adipose-derived stromal cells." Kyoto University, 2010. http://hdl.handle.net/2433/120606.

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Enck, Robert E., Fadi Abushahin, and John B. Bossaer. "Soft Tissue Calcification Secondary to Imatinib Mesylate in a Patient with Gastrointestinal Stromal Tumor." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/2321.

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Imatinib mesylate has been associated with the changes in bone turnover. We report a case of the development of tissue calcification in a patient on long-term therapy with this drug. A 48-year-old male patient with gastrointestinal stromal tumor and liver metastasis complained of abdominal pain. His treatment included hepatic artery chemoembolization and partial hepatectomy in addition to chronic imatinib mesylate for 4 years. On physical examination, he had a peritoneal mass just beneath the laparotomy incision scar that, after resection, was found to be dystrophic bone formation. Based on th

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Fujimoto, Masakazu. "Stromal plasma cells expressing immunoglobulin G4 subclass in non-small cell lung cancer." Kyoto University, 2015. http://hdl.handle.net/2433/199170.

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Shea, Amanda Ann. "The Impact of Adipose-Associated Stromal Cells on the Metastatic Potential of Ovarian Cancer." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/54562.

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Obesity is a major global health concern due to its steadily increasing rates and significant contribution to numerous diseases, including cancer. Ovarian cancer specifically, is associated with a 30% increased risk with obesity, although the mechanisms for this are unknown. Waist-to-hip ratio has been especially associated with ovarian cancer, suggesting that visceral fat may be the greatest contributor. Here, we investigated individual visceral fat depots as independent contributors to cancer progression, specifically focusing on adipose tissue-derived stem and progenitor cells, which have p

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Shea, Amanda A. "The Impact of Adipose-Associated Stromal Cells on the Metastatic Potential of Ovarian Cancer." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/54562.

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Obesity is a major global health concern due to its steadily increasing rates and significant contribution to numerous diseases, including cancer. Ovarian cancer specifically, is associated with a 30% increased risk with obesity, although the mechanisms for this are unknown. Waist-to-hip ratio has been especially associated with ovarian cancer, suggesting that visceral fat may be the greatest contributor. Here, we investigated individual visceral fat depots as independent contributors to cancer progression, specifically focusing on adipose tissue-derived stem and progenitor cells, which have p

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19

Denost, Quentin. "Ingénierie tissulaire en chirurgie colorectale : du défect pariétal au remplacement d’organe : étude in vitro et in vivo." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0188/document.

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L’ingénierie tissulaire représente un nouvel outil en chirurgie colorectale pour la prévention et le traitementdes fistules et pour la substitution sphinctérienne et rectale après chirurgie d’exérèse. Ce travail comprend :1) La sélection de la composante matricielle : in vivo, en remplacement d’un défect de paroi colique, 2matrices ont été comparées chez 16 lapins : groupe A, matrice de sous-muqueuse intestinale de porcdécellularisée (SIS, BioDesign®), référente; groupe B, matrice de chitosane, innovante. Les animaux étaientsacrifiés à 4 et 8 semaines. A 8 semaines, une régénération épithélial

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Mäkelä, T. (Tuomas). "Systemic transplantation of bone marrow stromal cells:an experimental animal study of biodistribution and tissue targeting." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526206547.

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Abstract Bone marrow mesenchymal stromal cells (MSCs) and mononuclear cells (BM-MNCs) have shown great therapeutic potential in various clinical settings. Although intravascular transplantation of the cells constitutes the optimal delivery route, massive pulmonary entrapment, with the threat of embolization, remains a major obstacle for using this type of therapy. Because pulmonary entrapment is at least partially mediated by adhesion molecules, cell surface modification could enhance pulmonary passage. We used a porcine model of allogeneic MSC and autologous BM-MNC transplantation and radionu

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Partridge, Simon William. "The influence of hydroxyapatite nanoparticles on human mesenchymal stromal cells : application in tissue engineered constructs." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3446.

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Osteoarthritis (OA) is a debilitating disease characterised by degradation of the articular cartilage and changes in the subchondral bone. Presently the gold standard treatment for OA is total joint replacement using metal, ceramic and non-degradable polymer materials. Tissue engineering using novel bioresorbable biomaterials has the potential to stimulate regeneration of bone and cartilage for early stage intervention in OA suffers. This thesis investigates the synthesis of hydroxyapatite nanoparticles (HAp) and techniques to generate poly (lactic acid) (PLA) HAp nanocomposites. The effect of

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Talamas, Ugalde Lucet Vanessa. "Effects of platelet rich plasma on marrow stromal cells differentiation seeded on three dimensional scaffolds." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2008. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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Boissier, Romain. "La fraction vasculaire stromale issue du tissu adipeux en urologie : propriétés thérapeutiques et modèle d'évaluation de la vasculocompétence du transplant rénal." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0691.

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La Fraction Vasculaire Stromale (FVS) est une population cellulaire obtenue par digestion enzymatique du tissu adipeux.L’objectif de ce travail était de transposer le modèle de la FVS en urologie, en évaluant ses propriétés thérapeutiques dans un modèle animal de lésion sphinctérienne urétrale puis en tant que matériel non invasif d’étude des altérations associé à la moindre fonction de transplants rénaux prélevés chez le donneur marginal, ou ECD (Extended Criteria Donor).1. L’injection de FVS autologue dans un modèle porcin de lésion urétérale entrainait une réduction significative de la surf

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MERAVIGLIA, VIVIANA. "Human mesenchymal stromal cells: how the tissue of origin influences plastic properties and microRNA expression profile." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/51144.

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MicroRNAs are key modulators at molecular level in different biological processes, including determination of cell fate and differentiation. Herein, microRNA expression profiling experiments were performed on syngeneic cardiac and bone marrow mesenchymal stromal cells cultured in standard growth medium and then in vitro exposed to adipogenic, osteogenic, cardiomyogenic and endothelial differentiation media. Analysis identified a tissue-specific microRNA signature composed by 16 microRNAs that univocally discriminated cell type of origin and that were completely unaffected by in vitro different

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Kavlock, Katherine Dulaney. "Effect of Mechanical Environment on the Differentiation of Bone Marrow Stromal Cells for Functional Bone Tissue Engineering." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/26660.

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Bone is the second most transplanted tissue after blood and the need for bone graft materials continues to rise at an average annual growth rate of over 18%. An engineered bone substitute consisting of a bone-like extracellular matrix deposited on the internal pores of a resorbable biomaterial scaffold is postulated to stimulate normal bone remodeling when implanted in vivo. Part one of this engineering strategy, the deposition of bone-like extracellular matrix, can be achieved by the directed differentiation of progenitor cells such as bone marrow stromal cells (BMSCs). Part two of the eng

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Sharp, Lindsay Ann. "The Use of Dynamic Fluid Flow Strategies for Bone Tissue Engineering Applications." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/29224.

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Bone is the second most transplanted tissue in the body, with approximately 2.2 million bone graft procedures performed annually worldwide. Currently, autogenous bone is the gold standard for bone grafting due to its ability to achieve functional healing; however, it is limited in supply and results in secondary injury at the donor site. Tissue engineering has emerged as a promising means for the development of new bone graft substitutes in order to overcome the limitations of the current grafts. In this research project, the specific approach for bone tissue engineering involves seeding osteo

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Zhou, Yinghong. "Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/63002/1/Yinghong_Zhou_Thesis.pdf.

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The body of work presented in this dissertation has demonstrated that the interactions between donor cells and host cells are critical for bone repair and regeneration. The donor cells secrete VEGF which activates the downstream PI3K/Akt signaling pathway, ultimately leading to host cell recruitment and robust bone regeneration. The findings from this dissertation may provide a scientific rationale for the development of novel therapeutic strategies in the treatment and management of bone defects.

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Vaidya, Prasad Avdhut. "Alternative strategies to incorporate biomolecules within electrospun meshes for tissue enginering." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/52583.

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Rupture of the anterior cruciate ligament (ACL) is one of the most common ligamentous injuries of the knee. Post rupture, the ACL does not heal on itself due to poor vasculature and hence surgical intervention is required to treat the ACL. Current surgical management of ACL rupture consists of reconstruction with autografts or allografts. However, the limitations associated with these grafts have prompted interest in tissue engineered solutions that combine cells, scaffolds and stimuli to facilitate ACL regeneration. This thesis describes a ligament tissue engineering strategy that involves in

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Walsh, Shane Benedict. "Characterising demixed polymer surfaces to stimulate mesenchymal stromal cell activity and influence tissue development during osteochrondral regeneration." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/3082.

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Osteoarthritis (OA) is defined clinically as the world’s leading cause of joint disease. Better understanding of the disease aetiology, contributing factors and improved imaging technologies has changed how we can treat this disease. Early intervention and long-term implant integration has inspired a new generation of biomaterials, able to influence local biological events in situ. The response of cells to their physical environment is known to regulate their proliferation, phenotype, gene expression and differentiation. To rebuild tissue with the appropriate structural and cellular organisati

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Wu, Shan Ph D. Massachusetts Institute of Technology. "Rational design to control multipotent stromal cell migration for applications in bone tissue engineering and injury repair." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67198.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 151-162).<br>Multipotent stromal cells derived from bone marrow hold great potential for tissue engineering applications because of their ability to home to injury sites and to differentiate along mesodermal lineages to become osteocytes, chondrocytes, and adipocytes to aid in tissue repair and regeneration. One key challenge, however, is the scarcity of MSC numbers isolated from in vivo, suggesting a role for biomime

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Bronzini, Ilaria. "A comprehensive study of adult stromal cells derived from mesenchymal tissues and their application in tendon regeneration." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422082.

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This research project focused on study of adult stromal cells derived from equine and canine mesenchymal tissue and the application of these cell sources in musculoskeletal injuries, particularly in tendon repair. Adult MSCs gained general attention in both human and veterinary medicine, however despite the advances in this field, much studies are needed in order to better understand MSCs behavior. With this goal the following research project focused on: - A comprehensive characterization and study in vitro of mesenchymal stromal cells derived from peripheral blood of horses (ePB-MSCs) and f

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Byers, Benjamin Allen. "In Vitro and In Vivo Characterization of a Cell Source for Bone Tissue Engineering Applications: Primary Bone Marrow Stromal Cells Overexpressing the Osteoblast-Specific Transcriptional Activator Runx2/Cbfa1." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5260.

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Bone tissue engineering strategies are currently being developed as alternative mechanisms to address the clinical demand for bioactive and biomechanical graft material. To date, these efforts have been largely restricted by inadequate supply of committed osteoprogenitor cells and loss of osteoblastic phenotype expression following in vitro culture and expansion. The objective of this thesis research was to address the cell sourcing limitations of tissue-engineered bone grafts through constitutive and sustained overexpression of the osteoblast-specific transcriptional activator Runx2/Cbfa1 i

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Bambuliak, A. V. "Efficiency of use of osteoplastic materials combined with stromal cells from the adipose tissue in patients with periodontitis." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17824.

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Bashur, Christopher Alan. "Effect of Electrospun Mesh Diameter, Mesh Alignment, and Mechanical Stretch on Bone Marrow Stromal Cells for Ligament Tissue Engineering." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/27949.

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The overall goal of this research project is to develop methods for producing a tissue engineered ligament. The envisioned tissue engineering strategy involves three steps: seeding bone marrow stromal cells (BMSCs) onto electrospun scaffolds, processing them into cords that allow cell infiltration, and conditioning them with uniaxial cyclic stretch. These steps were addressed in three complimentary studies to establish new methods to engineer a tissue with ligament-like cells depositing organized extracellular matrix (ECM). In the first study scaffold topographies were systematically varied

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Baulier, Edouard. "Évaluation du potentiel thérapeutique des cellules souches issues du liquide amniotique et de la fraction vasculaire stromale du tissu adipeux dans un modèle pré-clinique porcin de donneur décédé après arrêt cardiaque : application à la transplantation rénale." Thesis, Poitiers, 2014. http://www.theses.fr/2014POIT1405.

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La transplantation rénale, thérapie de choix de l'insuffisance rénale chronique terminale, est limitée par une pénurie d'organes. Les greffons issus de donneurs décédés par arrêt cardiaque (DDAC) peuvent contribuer à pallier à cette pénurie au prix de stratégies thérapeutiques visant à améliorer l'issue de la transplantation. Les cellules souches mésenchymateuses (MSC) de l'organisme adulte ont des propriétés de sécrétion, d'immunomodulation et de différenciation intéressantes dans ce contexte.L'objectif de ce travail est d'évaluer, dans un modèle pré-clinique porcin de DDAC, le potentiel thér

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Music, Ena. "Optimisation of methods for driving Chondrogenesis of human and ovine bone marrow–derived stromal cells." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/207820/1/Ena_Music_Thesis.pdf.

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This thesis investigated the effects of different molecules and oxygen levels on the quality of engineered cartilage tissues produced using both human and sheep bone marrow–derived stromal cells. As damaged cartilage cannot repair naturally, it is hoped that cell-based repair strategies can delay the need for joint replacement surgery due to osteoarthritis, which affects 1 in 10 Australians.

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Honda, Michitaka. "Use of adipose tissue-derived stromal cells for prevention of esophageal stricture after circumferential EMR in a canine model." Kyoto University, 2014. http://hdl.handle.net/2433/188643.

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Perko, John C. "Applying Mesenchymal Stromal Cells and Platelet-Rich Plasma on a Collagen Matrix to Improve Fascial Repair." Youngstown State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1342115316.

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Lydic, Melissa. "The Characteristics of Rabbit and Rat Mesenchymal Stromal Cell Growth and Attachment to Mesh Used in Hernia Repair." Youngstown State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1278102053.

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Mareddy, Shobha R. "Characterization of bone marrow stromal clonal populations derived from osteoarthritis patients." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/17151/1/Shobha_Reddy_Mareddy_Thesis.pdf.

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This work is concerned with the characterization of mesenchymal stem cells (MSC) specifically from bone marrow samples derived from patients with osteoarthritis (OA). The multilineage potential of mesenchymal stem cells as well as their ease of exvivo expansion makes these cells an attractive therapeutic tool for applications such as autologous transplantation and tissue engineering. Bone marrow is considered a source of MSC. However, there is a general assumption that the occurrence of MSCs and their activity in bone marrow diminishes with age and disease. This prompted us to isolate and iden

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Mareddy, Shobha R. "Characterization of bone marrow stromal clonal populations derived from osteoarthritis patients." Queensland University of Technology, 2008. http://eprints.qut.edu.au/17151/.

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This work is concerned with the characterization of mesenchymal stem cells (MSC) specifically from bone marrow samples derived from patients with osteoarthritis (OA). The multilineage potential of mesenchymal stem cells as well as their ease of exvivo expansion makes these cells an attractive therapeutic tool for applications such as autologous transplantation and tissue engineering. Bone marrow is considered a source of MSC. However, there is a general assumption that the occurrence of MSCs and their activity in bone marrow diminishes with age and disease. This prompted us to isolate and iden

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Yamashiro, Hiroyasu. "Efficient Proliferation and Adipose Differentiation of Human Adipose Tissue-derived Vascular-stromal Cells Transfected with Basic Fibroblast Growth Factor Gene." Kyoto University, 2003. http://hdl.handle.net/2433/148490.

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Nili, Ahmadabadi Elham. "Development of a novel mesenchymal stromal cell (MSC) therapy for repairing the cornea." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122897/1/Elham_Nili%20Ahmadabadi_Thesis.pdf.

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This thesis has produced advances in our understanding of the biology and potential clinical application of stem cells to aid the treatment of patients with severe eye injuries. This research evaluated the therapeutic potential of a stem cell (called Mesenchymal Stromal Cells (MSCs)) isolated from the peripheral margin of the cornea, known as the limbus. Firstly, a method for routinely isolation and propagation of human limbal MSCs was optimized. Subsequently, the performance of those cells on a silk fibroin membrane was examined.

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Steude, Jana Sofia [Verfasser]. "Mammographic breast density and hormonal, proliferative and stromal histopathologic markers in benign and malignant tissue of different ethnicities / Jana Sofia Steude." Kiel : Universitätsbibliothek Kiel, 2012. http://d-nb.info/1023681331/34.

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Thirlwell, Kayleigh. "Tissue origin dictates mesenchymal stromal cell chemokine and chemokine receptor repertoire and predicts in vitro chemotactic activity under homeostatic and inflammatory conditions." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8951/.

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Due to their anti-inflammatory and immunomodulatory properties, mesenchymal stromal cells (MSCs) are under intense investigation in many pre-clinical and clinical trials as a potential cellular therapy to be used in an array of clinical settings. The majority of the literature surrounding MSC phenotype and function is derived from studies focusing on bone marrow (BM) derived MSCs. Recently however, it has become apparent that MSCs can be isolated in a less invasive manner, from the majority of tissues in the human body. In light of this, many studies have been published promoting the use of al

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MOCCHI, MICHELA. "Veterinary pharmaceutical development of freeze-dried secretome from mesenchymal stromal cells: GMP production and clinical trials for equine and canine tissue regeneration." Doctoral thesis, Università degli studi di Pavia, 2022. http://hdl.handle.net/11571/1448464.

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Burk, Janina, Claudia Gittel, Sandra Heller, et al. "Gene expression of tendon markers in mesenchymal stromal cells derived from different sources." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-157823.

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Background: Multipotent mesenchymal stromal cells (MSC) can be recovered from a variety of tissues in the body. Yet, their functional properties were shown to vary depending on tissue origin. While MSC have emerged as a favoured cell type for tendon regenerative therapies, very little is known about the influence of the MSC source on their properties relevant to tendon regeneration. The aim of this study was to assess and compare the expression of tendon extracellular matrix proteins and tendon differentiation markers in MSC derived from different sources as well as in native tendon tissue. MS

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Wojtowicz, Abigail M. "Genetically-engineered bone marrow stromal cells and collagen mimetic scaffold modification for healing critically-sized bone defects." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/34705.

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Non-healing bone defects have a significant socioeconomic impact in the U.S. with approximately 600,000 bone grafting procedures performed annually. Autografts and allografts are clinically the most common treatments; however, autologous donor bone is in limited supply, and allografts often have poor mechanical properties. Therefore, tissue engineering and regenerative medicine strategies are being developed to address issues with clinical bone grafting. The overall objective of this work was to develop bone tissue engineering strategies that enhance healing of orthotopic defects by targeti

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Roggel, Florian [Verfasser]. "Ultrasonographische und histologische Untersuchungen von künstlich erzeugten und mit kultivierten mesenchymalen stromalen Zellen aus Fettgewebe (Adipose Tissue Mesenchymal Stromal Cells, AT-MSCs) behandelten Läsionen der oberflächlichen Beugesehne bei Pferden / Florian Roggel." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1037878078/34.

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Raicevic, Gordana. "Influence of microbial products and inflammation on the function of mesenchymal stromal cells isolated from different sources." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209790.

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Mesenchymal stromal cells (MSC) are adherent, clonogenic, fibroblast-like cells endowing with unique multipotent differentiation potential and immunosuppressive properties. They are considered as promising candidates for regenerative medicine and immunotherapy. <p>MSC can be isolated from different tissue sources including bone marrow (BM), adipose tissue (AT) and Wharton’s Jelly (WJ). Although fulfilling the ISCT criteria required to be recognized as MSC, MSC from these different sources could disclose some differences taking into account their different anatomical origin and ontogeny as well

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