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Articles de revues sur le sujet « Sustained Release Matrix Tablet »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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1

Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre

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Rajesh, Kuma, and Sharma Vijay. "A Review on Sustained Release Matrix Tablet." International Journal of Current Pharmaceutical Review and Research 15, no. 04 (2023): 205–20. https://doi.org/10.5281/zenodo.12635940.

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AbstractThe objective of the study was to explore the objectives, advantages and disadvantages ofsustained release matrix tablet. Different types of sustained release matrix tablet have beenexplained briefly along with various types of polymers that are used during the formulation.Various preparation methods are discussed here. There are certain physicochemical factorsand biological factors which affect the release of drug from the matrix are also discussedbriefly. These matrix tablets also have to go through many evaluation tests like thickness,hardness of tablet, friability, weight variation

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Bhowmick, Argha, Arup Manna, Sanat Kumar Mandal, et al. "Formulation Development, Evaluation and Statistical Optimization of the Release Rate of Oral Sustained Release Matrix Tablet of Aceclofena." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 4 (2022): 6026–33. http://dx.doi.org/10.37285/ijpsn.2022.15.4.2.

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Aim: This work aimed to develop a sustained released hydrophilic matrix tablet of Aceclofenac for better therapeutic action.  Background: Conventional dosage form didn't provide the desired level of drug release. Even many-marketed sustained-release tablets didn't always meet the satisfactory level of drug release. It was a challenging job for pharmaceutical scientists to develop a well-sustained release formulation. Keeping this perspective in mind a robust sustained release formulation was designed, developed and optimized with nontoxic, inert viscoelastic, semisynthetic polymers which

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K., Rekha Rani* Y. Navya Reddy R. Mohana Priya. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE DOSAGE FORM OF KETOPROFEN." indo American Journal of Pharmaceutical Sciences 04, no. 05 (2017): 1384–90. https://doi.org/10.5281/zenodo.804916.

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Sustained release Ketoprofen matrix tablets were prepared by direct compression method. The nature of the polymer influences the physical and release characteristics of the matrix tablet. The hydrophobic polymer, Ethyl cellulose has retarded the drug release from the tablet and the hydrophilic polymer, HPMC (15 cps) has release the drug. While making the combination of both hydrophilic and hydrophobic polymers i.e HPMC and Ethylcellulose with optimized ratio (F7) leads to sustained release of drug from matrix tablet for 12 hours was observed Key words: Ketoprofen, HPMC (15 cps), Ethyl cellulos

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Kanke, Pralhad K., Pankaj Sawant, Ajit Jadhav, and Md Rageeb Md Usman. "A REVIEW ON DISINTEGRATION CONTROL MATRIX TABLETS." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 19–22. http://dx.doi.org/10.22270/jddt.v8i5.1852.

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A number of sustained release formulations are available in the market which successfully sustained the drug release over a prolonged period of time by different mechanisms. The new approach for sustaining the drug release is disintegration control matrix tablet which sustained the drug release up to 24hrs by controlling the disintegration rate of tablet. Disintegration control matrix tablet (DCMT) mainly forms the granules containing drug and disintegrating agent such as low substituted hydroxyl propyl cellulose by various methods such as solid dispersion technique. The sustained release of d

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Das, Urmi, and Mohammad Salim Hossain. "Effects of release modifier on Carvedilol release from Kollidon SR based matrix." International Current Pharmaceutical Journal 1, no. 8 (2012): 186–92. http://dx.doi.org/10.3329/icpj.v1i8.11248.

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Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcry

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Dr., N. Sandeepthi *and Dr. L. Satyanarayana. "FORMULATION AND EVALUATION OF NAPROXEN SUSTAINED RELEASE MATRIX TABLET." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1498–510. https://doi.org/10.5281/zenodo.1204477.

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The present investigation is concerned with development and evaluation of Sustained release matrix tablets containing Naproxen using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC K100M & HPMC K4M).Preformulation study was done initially which include characterization of polymers, drug identification, FTIR compatibility and result directed for the further course of formulation. The tablets were prepared by direct compression method and evaluation done. Tablets were compressed by tablet compression machine (Karnavati Rimek Mini press1)and evaluated with different parameters l

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Singh, Neha, Durga Pandey, Nilesh Jain, and Surendra Jain. "Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 23–31. http://dx.doi.org/10.22270/jddt.v11i1.4481.

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The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24

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Pralhad, Kanke. "DEVELOPMENT OF DISINTEGRATION CONTROL MATRIX TABLETS OF FEBUXOSTAT." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (2018): 12–20. http://dx.doi.org/10.22270/ajprd.v6i4.392.

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Disintegration control matrix tablet (DCMT) is a new approach for poorly water soluble drugs which successfully sustain the release up to 24hrs by controlling the disintegration rate of tablet. DCMT mainly forms the granules containing drug febuxostat and disintegrant sodium alginate which controls the release of febuxostat by controlling the rate of disintegration in wax coating plays an important role. The sustained release of drug is maintained by increasing the wax coating or decreasing the amount of disintegrant. The release of drug from tablet is uniform throughout till all the drug rele

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Das, Urmi, and Mohammad Salim Hossain. "Effects of release modifier on Carvedilol release from Kollidon SR based matrix." International Current Pharmaceutical Journal 1, no. 8 (2012): 186. http://dx.doi.org/10.3329/icpj.v1i8.11095.

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<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of

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Mohaniya, Payal, Dipti Modi, and Rajat Pawar. "A REVIEW ON SUSTAINED RELEASE MATRIX TABLET." International Journal of Pharmaceutical Sciences and Medicine 9, no. 2 (2024): 52–58. http://dx.doi.org/10.47760/ijpsm.2024.v09i02.007.

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In the present study Sustained release matrix tablet is formulated mainly by wet granulation or direct compression method .Sustained release drug delivery maintains the therapeutic concentration of drug in the bloodstream over a long period of time and thus improves patient compliance by reducing frequency of dosing, minimized fluctuations in drug levels, lowering the therapeutic index and improving treatment efficacy. Nowadays Matrix tablets as oral solid dosage form are most suitable for the sustained release drug delivery. In a matrix system a drug is homogeneously dispersed or dissolved wi

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Rahman, Md Ziaur, Sayed Koushik Ahamed, Sujan Banik, and Mohammad Salim Hossain. "Release Profile of Losartan Potassium from Formulated Sustained Release Matrix Tablet." Bangladesh Pharmaceutical Journal 16, no. 2 (2015): 177–83. http://dx.doi.org/10.3329/bpj.v16i2.22301.

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The present study was undertaken to develop sustained release (SR) matrix tablets of Losartan potassium, an angiotensin-II antagonist for the treatment of hypertension. The tablets were prepared by direct compression method along with Kollidon SR and Methyl Cellulose as release retardant polymers. The evaluation involves two stages- the physical properties studies of tablets and in vitro release kinetics assessment. The USP paddle method was selected to perform the dissolution test and 900 ml phosphate buffer of pH 6.8 was used as dissolution medium at 50 rpm at 370C. The release kinetics were

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Mondal, Nita. "THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 1. http://dx.doi.org/10.22159//ijap.2018v10i1.21935.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controll

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Rekha D Kadam, Gunesh N. Dhembre, Umesh T. Jadhao, et al. "Formulation and evaluation of sustained release matrix tablet of ketoprofen." World Journal of Biology Pharmacy and Health Sciences 20, no. 2 (2024): 295–304. http://dx.doi.org/10.30574/wjbphs.2024.20.2.0875.

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The aim of the study was the formulation of the sustained release matrix tablet of Ketoprofen. The sustained release tablet was prepared by wet-granulation method. The tablets were formulated using hydrophilic polymer HPMC K4M and xanthan gum. Preformulation compatibility studies indicate that there is no interaction between the excipient and the drug. Total seven batches were prepared and powder blends before compression was subjected for evaluation of flow properties. All the parameter was found to be within the limit showing good flow property. After compression, the entire tablet batch was

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Lamkhade, Snehal* Shelke Pranali Dr. Wakale Vijaykumar S. "A Brief Review on Quinine Sulphate Sustained Release Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4558–64. https://doi.org/10.5281/zenodo.15527245.

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Malaria continues to pose a significant global health burden, particularly in developing regions with limited healthcare access. Conventional antimalarial therapies, while effective, suffer from limitations such as short drug half-lives, poor patient compliance, and the rising threat of drug resistance. In response to these challenges, sustained release (SR) tablet formulations are emerging as a promising strategy to optimize antimalarial drug delivery. This review paper presents a comprehensive overview of the formulation approaches, materials used, pharmacokinetic benefits, and clinical impl

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Avinash, V. Dhobale, Siddaiah M., Shaileh M., and Madhu Babu A. "Formulation, Evaluation and Comparison of Sustained Release Matrix Tablet of Losartan Potassium Using Natural Polymers." American Journal of PharmTech Research 13, no. 03 (2023): 39–53. https://doi.org/10.5281/zenodo.8046928.

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ABSTRACT The aim of this research work was to Evaluation of Some Natural Polymer used as Sustained Release Matrix Tablet, any pharmaceutical formulation contains two ingredients one is the active ingredient and other is an excipients. An excipients help in the manufacturing of dosage form and it also improves physicochemical parameters of the dosage form. Polymers play an important role as excipients in any dosage form. They influence drug release and should be compatible, non-toxic, stable, economic etc. and develop a fixed Dose Combination product in a two different strength using same blend

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Priya, Patil*and Vijay R. Mahajan. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET QUETIAPINE FUMARATE BY USING NATURAL POLYMER." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2018): 4859–67. https://doi.org/10.5281/zenodo.1134591.

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The purpose of present study was to develop once a day sustained release matrix tablet of Quetiapine Fumarate by using natural polymer viz. Xanthan gum and isolated fenugreek mucilage. Varying ratios of drug and polymer like were selected for sustained release tablet by using direct compression method. After fixing the ratio of drug and polymer for Sustain the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling material. After evaluation of physical properties of tab

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Anuradha, R. Narwade, and M. Mahale A. "A Research on: Formulation and Evaluation of Sustained Release matrix Tablets." GSC Biological and Pharmaceutical Sciences 29, no. 2 (2024): 123–57. https://doi.org/10.5281/zenodo.14753754.

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The study focused on developing a sustained release matrix tablet of Mosapride Citrate to achieve prolonged therapeutic effects, reduce side effects, and improve patient compliance by minimizing dosing frequency. Mosapride Citrate, with a half-life of 2-3 hours, was used as a model drug. Matrix tablets were prepared using different viscosity grades of Eudragit through direct compression and evaluated. Results indicated that polymer matrices alone were insufficient for 8-hour sustained release, whereas a combination of Eudragit RS 100, Eudragit RL 100, and Eudragit E 100 provided effective sust

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Thanh, Duyen Nguyen Thi, Duc Hoang Van, Minh Vo Xuan, Xuan Dam Thanh Thanh, and Tung Bui Thanh. "Design and Optimization of Hydrophilic Matrix-based Sustained Release Felodipine Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 3 (2018): 4136–44. http://dx.doi.org/10.37285/ijpsn.2018.11.3.8.

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Felodipine is a calcium channel blocker used for hypertensive and unstable angina treatments. The sustained release formulations of felodipine have advantages of achieving good therapeutic effects, increasing the bioavailability, decreasing dosing times per day and reducing side effects.The aim of our study was to study the formulation screening, then use an experiment design for formulating a hydrophilic matrix sustained release tablet of felodipine. Methods: The optimization process had the influences of the chosen excipients (including HPMC E4M, HPMC E15LV) on the drug release. Three depend

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Mehta, Mandev, H. S Keerthy, and Rajkumar Prasad Yadav. "Sustained Release Matrix Tablet: An Overview." Asian Journal of Pharmaceutical Research and Development 9, no. 3 (2021): 112–17. http://dx.doi.org/10.22270/ajprd.v9i3.954.

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Sustained Release is also a promising method for reducing medication side effects by preventing the therapeutic concentration of the drug from fluctuating in the body.The basic rationale of a sustained drug delivery system is to optimise a drug's biopharmaceutical, pharmacokinetic, and pharmacodynamic properties in order to maximise utility, minimise side effects, and cure the disease. The drug release rate is regulated by the matrix. HPMC and other release retardants can help with sustained release, so they are used as a key excipient in the formulation.The method entails compressing a mixtur

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Viswanath, V., U. Chandrasekhar, B. Narasimha Rao, and K. Gnana Prakash. "Development and evaluation of sustained release matrix tablets of losartan potassium." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 1, no. 04 (2016): 127–32. http://dx.doi.org/10.21477/ijapsr.v3i1.4858.

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The objective of the present study was to develop a sustained release matrix tablets of Losartan potassium, an anti hypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using different drug and polymer ratios. Hydrophilic natural polymers like xanthan Gum (XG), guar gum and cellulose were used. Compatibility of the drug with various excipients was studied. The compressed tablets were evaluated and showed compliance with Pharmacopoeial limits. Formulation was optimized (F2) on the basis of acceptable tablet properties and in vitro drug release. The re

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Ujjwal, Kukreti, Nainwal Nidhi, Ale Yogita, et al. "Release Kinetic of Sustained Release Matrix Tablet of Linezolid Containing Polymer Blend." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1479–84. http://dx.doi.org/10.25258/ijpqa.15.3.60.

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Tuberculosis (TB) is a bacterial infection mainly affecting the lungs. TB is a major health problem worldwide and the occurrence of extensively drug-resistant TB (XDR-TB) and multidrug-resistant TB (MDR-TB) offers considerable hurdles to effective treatment and disease management. The growth of treatment-resistant Mycobacterium TB strains has prompted the investigation of alternate therapeutic techniques, including the application of sustained drug delivery. Sustained-release drugs reduce the need for frequent dosing can extend the effects of linezolid by 8 to 12 hours, thus improving the pati

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Ankit, Singh* Rajesh Gour** &. Akhlesh Kumar Singhai***. "MODIFIED RELEASE OF MEDICATION DELIVERY: A REVIEW." International Journal of Scientific Research and Modern Education (IJSRME) 8, no. 1 (2023): 33–41. https://doi.org/10.5281/zenodo.7806086.

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In terms of drug delivery methods, the oral route is the most popular. However, the traditional dosage form has a few drawbacks that could be fixed by altering the current dosage form. A regulated and sustained drug delivery system prolongs the duration of action by slowing the drug's release rate and maintaining a consistent plasma drug concentration. The matrix tablet is a crucial tool among the numerous formulation options for sustained release tablets. This makes issues like poor patient compliance, multiple doses, and see-saw oscillations simply manageable. A number of hydrophilic or

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Thombre, Nilima, Archana Aher, and Pranali Shimpi. "Formulation Development and Evaluation of Gum Damar Based Sustained Release Matrix Tablet of Metoprolol Succinate." Asian Journal of Pharmaceutical Research and Development 8, no. 3 (2020): 81–86. http://dx.doi.org/10.22270/ajprd.v8i3.752.

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Background: An oral dosage form containing sustained released matrix tablet used the natural polymer in the replacement of synthetic polymer. Objective: To prepare sustained release matrix tablet using natural polymer damar & drug Metoprolol Succinate. Material and method: Metoprolol Succinate using Gum Damar as release retardant were prepared by wet granulation technique using 23 factorial design with the quantity of gum damar, concentration of the microcrystalline cellulose& dicalcium phosphate (DCP) as variables. Matrix tablets were prepared using different strengths of

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Siddiqui, Mehak, L. K. Omray, and Pushpendra Soni. "Formulation of Metformin Sustained Release Tablet Using Natural Polymer." Journal of Drug Delivery and Therapeutics 11, no. 2 (2021): 31–37. http://dx.doi.org/10.22270/jddt.v11i2.4579.

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The overall objective of the present work was to develop an oral sustained-release (SR) Metformin tablet that is prepared by the direct compression method by using hydrophilic hydroxyl propyl methyl cellulose (HPMC) and Guar gum polymer alone as well as in combination at different concentrations. Metformin is a biguanide that has a relatively short plasma half-life. It has low absolute bioavailability. All the properties were evaluated for thickness, weight variation, hardness and drug content uniformity and in vitro drug release. The mean dissolution time is used to characterize the drug rele

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Mangesh, Dagale* Dr. Nilesh Gorde Kartik Shinde Ashwini Karnakoti Prajwal Birajdar. "Current Trends and Challenges in Sustained-Release Tablet Formulations: A Comprehensive Review." International Journal of Scientific Research and Technology 2, no. 1 (2025): 266–76. https://doi.org/10.5281/zenodo.14678430.

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The development of sustained release (SR) matrix tablets has garnered significant attention in modern pharmaceutical research owing to their ability to maintain prolonged therapeutic action, improve patient compliance, and enhance drug bioavailability. Among various approaches for achieving sustained release, the use of natural gums as matrix-forming agents has emerged as a promising strategy due to their biocompatibility, biodegradability, non-toxicity, and economic viability. This review focuses on the formulation, evaluation, and applications of SR matrix tablets, with a special emphasis on

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Sharma, Diksha, Dhruv Dev, D. N. Prasad, Mansi Hans, and Ruchika Sahore. "To study the comparative dissolution profiles of sustained release tablets of metformin hydrochloride by using various hydrophilic polymers." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 374–85. http://dx.doi.org/10.22270/jddt.v9i3-s.2856.

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In this research study an attempt was made to formulate sustained release matrix tablets of Metformin Hydrochloride as it possesses relatively shorter plasma half-life, low bioavailability. The sustained release formulations of the drug were capable of maintaining the plasma level for 8-12 hours. The overall objective of this research was to formulate the tablet by using various hydrophilic polymers i.e. Xanthan gum, Guar gum, Aloe barbadensis and Methocel K4M. Tablets were prepared by wet granulation method. In Vitro studies were performed by USP XX apparatus I, basket and the data was analyz

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Tushar, D. Fegade, R. Patil Vijay, and A. Deshmukh Tushar. "Evaluation of Modified Gum From Pistacia Lantiscus As A Release Retardant Matrix In The Tablet Dosage Form." American Journal of PharmTech Research 13, no. 02 (2023): 07–18. https://doi.org/10.5281/zenodo.7878365.

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In the current investigation we formulated and evaluates matrix tablet using modified gum of <em>Pistacia lantiscus</em> gum (PLMG) as natural matrix forming agent used in various successively increasing concentration. The pre-compression study of the powder blends of drug, PLMG and other excipients were done by calculating bulk density, tapped density, angle of repose and carr’s index (% compressibility) and hausner’s ratio. The tablets using PLMG as matrix forming agent were prepared by direct compression method and prepared tablets were evaluated for thickness, hardness, weight

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Bisht, Tulsi, and Rishishwar Poonam. "A Comparative Study of Matrix Tablets Designed by Different Methods." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 2 (2017): 3645–52. http://dx.doi.org/10.37285/ijpsn.2017.10.2.2.

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The aim of present work was to develop once daily sustained release matrix tablet of aceclofenac by wet granulation technique using natural gums i.e.: gum acacia, guar gum and Xanthan gum. In this present study matrix tablets were prepared using three different methods and a comparative study was done. Aceclofenac sodium being the newer derivative of diclofenac having short biological half life (4hrs.), so it requires more than one dose per day to maintain therapeutic dose. The prepared tablets were evaluated for various parameters like weight variation, hardness, swelling index, friability, p

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Nikolic, Nenad, Djordje Medarevic, Svetlana Ibric, and Zorica Djuric. "Evaluation of formulation and effects of process parameters on drug release and mechanical properties of tramadol hydrocloride sustained release matrix tablets." Chemical Industry 69, no. 5 (2015): 503–10. http://dx.doi.org/10.2298/hemind140317069n.

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This study investigates using of high molecular weight polyethylene oxide (PEO WSR Coagulant) for the preparation of sustained release matrix tablets containing high dose, highly water soluble drug, tramadol HCl. Proportion of PEO polymer, type of insoluble filler, proportion of tramadol HCl, amount of drug in tablet, tablet diameter and compression pressure were recognized as critical formulation and process parameters and their influence on drug release and tablet mechanical properties was evaluated. Percentages of tramadol HCl released after 30 and 240 minutes were selected for evaluation o

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Kumari, Satish, Anchal Puri, Dhruv Dev, DN Prasad, and ,. Monika. "Formulation and evaluation of sustained release matrix tablet of metoprolol succinate by using xanthan gum and carbopol." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 309–16. http://dx.doi.org/10.22270/jddt.v9i3-s.2844.

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Metoprolol succinate is a β1 selective antagonist used as an Anti-hypertensive, Anti arrhythmic, Anti Angina. The aim of present investigation was to develop matrix tablets of Metoprolol succinate using different polymers.Metoprolol succinate matrix tablet was prepared by use of xanthan gum and carbopol-934 as a polymer initially by direct compression methods. Physicochemical compatibility of the drug with polymer was confirmed by IR spectroscopy and DSC. Metoprolol succinate matrix tablets were prepared by direct compression and wet granulation method using different polymers. All the formula

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Karmarkar, R. R., M. P. Wagh, S. R. Baviskar, S. H. Patil, and S. K. Khawshe. "FORMULATION DEVELOPMENT OF MATRIX TABLET OF STAVUDINE BY USING CARBOXY METHYL TAMARIND KERNEL POWDER AS A NOVEL DRUG RELEASE RETARDING AGENT." INDIAN DRUGS 52, no. 04 (2015): 28–36. http://dx.doi.org/10.53879/id.52.04.10235.

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The aim of the present study was to evaluate carboxy methyl tamarind kernal powder as a novel drug release retarding agent. To evaluate the same, sustained release matrix tablets of stavudine were prepared by using HPMC K4M and carboxy methyl tamarind kernal powder, by using a direct compression technique. The formulations were prepared by using different drug: polymer ratios into formulations such as F1 to F9. The compressed tablets were evaluated for thickness, hardness, friability, drug content and in vitro dissolution rates. Formulation F6, having a hardness of 5.46 ± 0.25, showed the desi

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Mahavarkar, Ruchira Vasant, Sapana Ahirrao, Sanjay Kshirsagar, and Vikas Rayate. "Formulation and evaluation of tamarind seed polysaccharide matrix tablet." Pharmaceutical and Biological Evaluations 3, no. 2 (2016): 241–55. https://doi.org/10.5281/zenodo.51071.

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Objective: The objective of using natural polymer was to modify the release rate of Diclofenac sodium from matrix tablet. The matrix forming agent like Tamarind seed Polysaccharide show sustained release property in tablet which is obtained naturally from fruit of Tamarindus indica L. belonging to Family Leguminosae. Methods: The sustained release matrix tablet of Diclofenac sodium were prepared by wet granulation technique using varying concentration of hydrophilic polymer i.e. TSP. Results: OF1 and OF2 both are optimized batch. The in vitro dissolution study was carried out for optimized as

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Jamshiya.E*, and Anju.P. "FORMULATION, EVALUATION AND OPTIMIZATION OF FLOATING MATRIX TABLETS OF CARVEDILOL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 1146–58. https://doi.org/10.5281/zenodo.1188894.

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Bilayer floating tablets were prepared by direct compression using HPMC K100M and Ethyl cellulose as the release controlling polymers and sodium bicarbonate as a gas generating agent. The optimum concentrations of the above ingredients were determined under experimental conditions and on the basis of trial batches of the tablets. In the present study bilayer tablet was prepared manually using single station punching machine. Accurately weighed 150mg of sustained release layer powder mixture was fed manually into die cavity. Sustained release layer was compressed at mild compression force (2-3

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Shani, Jashovam, Shimon Benita, Muhamed Abdulrazik, and Aharon Yerushalmi. "Efficacy of Sustained-Release Radioprotective Drugs in vivo." Zeitschrift für Naturforschung C 42, no. 11-12 (1987): 1323–27. http://dx.doi.org/10.1515/znc-1987-11-1229.

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In previous publications from this laboratory we suggested the use of radioprotective drugs in a sustained-release form as a practical way to cope with their high toxicity and quick metabolism and excretion. Cysteine and cysteamine, well-established radioprotectants, were used as model drugs and compressed at various concentrations (0-65%) into an insoluble tablet matrix, composed of ethylcellulose and stearic acid at various ratios and compression pressures. We demonstrated in vitro that when the release rate of the radioprotectants was measured under nitrogen, the kinetic data conformed with

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Anuradha R. Narwade and A. M. Mahale. "A Research on: Formulation and Evaluation of Sustained Release matrix Tablets." GSC Biological and Pharmaceutical Sciences 29, no. 2 (2024): 123–57. http://dx.doi.org/10.30574/gscbps.2024.29.2.0363.

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The study focused on developing a sustained release matrix tablet of Mosapride Citrate to achieve prolonged therapeutic effects, reduce side effects, and improve patient compliance by minimizing dosing frequency. Mosapride Citrate, with a half-life of 2-3 hours, was used as a model drug. Matrix tablets were prepared using different viscosity grades of Eudragit through direct compression and evaluated. Results indicated that polymer matrices alone were insufficient for 8-hour sustained release, whereas a combination of Eudragit RS 100, Eudragit RL 100, and Eudragit E 100 provided effective sust

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M., A. Shende* R. P. Marathe. "GASTROADHESIVE SUITABILITY STUDIES FOR BACLOFEN SUSTAINED RELEASE FORMULATION." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3315–25. https://doi.org/10.5281/zenodo.997182.

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The present study is to investigate gastromucoadhesive suitability of natural polysaccharides for development of baclofen sustained release tablet formulations by increase gastric residence. Baclofen formulations were prepared by wet granulation technique and evaluated blend by FTIR, DSC for compatibility, hardness, friability, in-vitro drug release, gastric residence and mucoadhesive strength. The formulated tablets were found to have good mechanical properties and official compliance. Based on in-vitro drug release pattern and ex-vivo mucoadhesive study; the formulation B4 with drug-polymer

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Amit, Dubey* Kusum Kumari Lubna Shaheen Manish Kumar Mo Rayyan Mohammad Saklain Mohd Aarif Khan. "Formulation and Evaluation of Paracetamol Matrix Tablet Using Natural Polymer." International Journal of Scientific Research and Technology 2, no. 5 (2025): 542–47. https://doi.org/10.5281/zenodo.15515718.

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Matrix tablets of Paracetamol were prepared utilizing natural polymer chitosan. The tablets represented sustained drug release which is required for the drugs like Paracetamol with low bioavailability and low half life. The tablets can sustain the drug release which can overcome such problems. Moreover the tablets contain chitosan which also is a permeability enhancer and hence could be utilized to increase the permeability of the drugs like Paracetamol with very low permeability. The tablets possess high potential for being developed as sustained release dosage forms for drugs with low permea

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Sujit, Ubale, Shinde Tejasvee, and Shaikh Adnan. "Phenhylephrine Hydrocloride Gastro Retentive Floating Matrix Tablets Design and in Vitro Evaluation." International Journal of Trend in Scientific Research and Development 3, no. 6 (2019): 588–92. https://doi.org/10.5281/zenodo.3588744.

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The objective of this research is to obtain sustained release of Phenylephrine hydrochloride. In this research work combination of natural and synthetic gums were used in different ratio to get sustain release different gas generating agents were used to float the tablet. Prepared powder blend is subjected to pre formulation studies. Then prepared tablet were evaluated for different evaluation tests. Finally dissolution data was subjected to various release kinetic models to understand release mechanism of drug. Sujit Ubale | Tejasvee Shinde | Adnan Shaikh "Phenhylephrine Hydrocloride Gas

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Soni, Shivani, Vivek Jain, Sunil Kumar Jain, and Pushpendra Kumar Khangar. "Formulations of sustained release matrix tablets of Furosemide using natural and synthetic polymers." Journal of Drug Delivery and Therapeutics 11, no. 5 (2021): 105–9. http://dx.doi.org/10.22270/jddt.v11i5.5122.

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The primary benefit of a sustained release dosage form compared to a conventional dosage form, is the consistent drug plasma concentration and consequently uniform therapeutic effect. Matrix system are preferential because of their ease, patient compliance etc, than traditional drug delivery which have several drawbacks like reiterated administration, variation in blood concentration level etc. The aim of the present research study was to develop and evaluate sustained release matrix tablets of furosemide using direct compression method using natural gummy and waxy materials (Xanthan gum, bees

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Yadav, Rajkumar Prasad, F. R. Sheeba, Mukesh Sharma, Bhargav A, Yaswanth Kumar, and Akshay Kumar Patel. "The Role of Matrix Tablet in Oral Drug Delivery System." Asian Journal of Pharmaceutical Research and Development 9, no. 2 (2021): 80–86. http://dx.doi.org/10.22270/ajprd.v9i2.930.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The important route of drug administered by oral route. The oral dosage forms developed and improvedthe patient compliance. The oral controlled release system has been developed by change to formulation scientist, due to the inability to restrain and localized of a system at target area of the gastrointestinal tract. The hydrophilic polymers are becomes product of choice for important ingredients formulation of sustained release dosage forms.The benefit of sustained release dosage forms are compared to the co

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Sahoo, S. K., A. Behera, and S. Patil. "FORMULATION AND EVALUATION OF LEVOFLOXACIN HEMIHYDRATE SUSTAINED RELEASE TABLET FROM HYDROPHILIC MATRICES." INDIAN DRUGS 49, no. 01 (2012): 43–49. http://dx.doi.org/10.53879/id.49.01.p0043.

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Stable sustained release tablets of levofloxacin hemihydrate were successfully prepared by wet granulation technique. Compatible excipients were selected and different formulations were prepared with varying proportion and grades of hydroxy propyl methyl cellulose. Tablets were prepared by compressing free flowing granules and evaluated for hardness, thickness, friability, weight variation, percentage drug content and drug release. As concentration of HPMC increased the drug release decreased might be due to increased amount of polymer around tablets provided gelation which inhibits the releas

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Khan, Niaz Ali, Amjad Khan, Rooh Ullah, et al. "Preparation and Characterization of Hydrophilic Polymer Based Sustained-Release Matrix Tablets of a High Dose Hydrophobic Drug." Polymers 14, no. 10 (2022): 1985. http://dx.doi.org/10.3390/polym14101985.

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The objective of this study was the preparation and characterization of a sustained-release matrix tablet containing a high-dose hydrophobic drug and its comparison with marketed products. In the present study, HPMC was applied as the matrix-forming polymer for the sustained release of clarithromycin (500 mg). The compatibility of clarithromycin and excipients was studied using a binary mixture approach and compatible excipients were selected. Matrix tablets were prepared using the high-shear wet granulation technique. Tablets were compressed using oblong (19 mm), shallow concave punches, unde

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Semalty, Mona, T. Bisht, and A. Semalty. "A Comparative Study of Triple-Layered Aceclofenac Matrix Tablets Formulated using Xanthan Gum and Guar Gum." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 1 (2012): 1621–26. http://dx.doi.org/10.37285/ijpsn.2012.5.1.5.

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The aim of the present study was to develop sustained release, multilayered-matrix tablet of aceclofenac using natural polymers-guar gum (GG) and xanthan gum (XG) as carrier for core matrix and hydroxyl propylmethyl cellulose (HPMC K-15M), sodium carboxymethylcellulose (NaCMC) and ethyl cellulose (EC) and polyvinylpyrrolidone (PVP-K30) for preparing bottom and top layers. The formulated tablets were evaluated for uniformity of weight, drug content, friability, hardness, thickness, swelling index and in vitro drug release. The physicochemical properties of tablets were found within the limits.

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Tarizza Puspa Anggrelia, Amelia Saputri Ginting, Yeka Khafidz Illa Rosyidah, et al. "Kajian Penggunaan Matriks Pada Formulasi Tablet Lepas Lambat." Jurnal Anestesi 2, no. 3 (2024): 251–60. http://dx.doi.org/10.59680/anestesi.v2i3.1249.

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This research discusses the use of matrices in sustained-release tablet formulations to optimize the active substance release profile. Extended-release tablets are a type of tablet formulation designed to release the active substance gradually in the body over a certain period of time. The main purpose of sustained-release tablets is to maintain drug levels in the blood or target area over a longer period of time, compared to conventional tablets which release the active substance quickly after ingestion. The method used in this research is a qualitative approach which aims to deepen an in-dep

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Dhananjay, M. Patil* Abdullah S. Farooque Vinod A. Bairagi. "FORMULATION, DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF METHIMAZOLE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 01 (2018): 209–25. https://doi.org/10.5281/zenodo.1145732.

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Sustained release tablets are generally taken once or twice a day during a course of treatment whereas in conventional dosage forms there is need to take 3-4 times dosage in a day to achieve the same therapeutic action. The drug was confirmed using FTIR, DSC and UV Spectroscopy, and tested for the stability of drug and polymer interactions. The tablet is formulated using carbopol, Ethyl cellulose and Eudragit, which makes it a matrix tablet, the carbopol is hydrophilic in nature and ramming two are hydrophobic in nature, which controls the release of drug. This formulation was tested for Mucoa

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Simran, Tanwar, Tikariya Komal, and Sharma Vimukta. "Formulation and Evaluation of Sustained Release Matrix Tablet of Nimesulide Using Pomegranate Peel and Acacia." International Journal of Pharmaceutical Sciences and Medicine 7, no. 7 (2022): 11–24. http://dx.doi.org/10.47760/ijpsm.2022.v07i07.002.

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The main objective of the study is the formulation and evaluation of sustained release matrix tablet of Nimesulide using pomegranate peel and acacia as natural polymer. The preformulation study of Nimesulide was conducted and λmax was found at 300 nm. The sustained release matrix tablet was prepared using Pomegranate peel as Release rate retardant, Acacia as polymer, Polyvinylpyrrolidone K30 as Binder, Isopropyl alcohol as Granulation solution, Micro Crystalline Cellulose as Diluent, Magnesium stearate as Lubricant and Talc as Glidant. Several formulations were prepared by taking different dru

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Jayashree, Bhamre* Shraddha Bhavsar Dr. Gokul Talele Bhushan Shewale. "A Systematic Review on Sustained Release Matrix Tablet." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 2555–64. https://doi.org/10.5281/zenodo.13212215.

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The abstract of the document provides an overview of sustained release drug delivery systems. It emphasizes the goal of delivering therapeutic levels of drugs to specific body sites over extended periods. The document discusses the increasing interest in sustained release systems due to high costs of developing new drugs, patent expirations, discovery of new polymers, and improvements in therapeutic efficiency and safety. Various types of matrix tablets, such as hydrophilic, fat-wax, plastic, biodegradable, and mineral matrices, are classified based on their properties and methods of drug rele

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Upadhyay, Uma, and KS Rathore. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN HYDROCHLORIDE." Pharmaceutical and Chemical Journal 1, no. 2 (2014): 5–13. https://doi.org/10.5281/zenodo.13691319.

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The aim of the current study is to design a sustained release matrix tablet of metformin HCl to maintain plasma level of drug for prolong period of time. Metformin HCl is antihyperglycemic agent used in the treatment of type II Non insulin dependent diabetes mellitus. Sustained release formulation of metformin HCl prolong drug absorption in the upper GI tract and permits once daily dosing in patient with type II diabetes mellitus. This newer formulation may enhance patient compliance compared to conventional immediate release metformin HCl. Metformin HCl present significant challenges due to i

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Suhel, Talha, Vivek Jain, Pushpendra Kumar Khangar, and Rupesh Kumar Jain. "Formulation and Evaluation of Metformin Hydrochloride Sustained Release Tablet." International Journal of Medical Sciences and Pharma Research 8, no. 3 (2022): 28–32. http://dx.doi.org/10.22270/ijmspr.v8i3.56.

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Metformin hydrochloride (MET) is an oral hypoglycemic agent which improves glucose tolerance in patients with type 2 diabetes and diminishes basal plasma levels of glucose. The aim of this study was to develop and optimize MET matrix tablets for SR application. The SR matrix tablet of MET was prepared by wet granulation technique using Polyvinyl pyrrolidone K30 and hydroxyl propyl methylcellulose of different viscosity grades (HPMC K4M, HPMC K15M, and HPMC K100M). The influence of varying the polymer ratios was evaluated. The excipients used in this study did not modify physicochemical propert

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