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Littérature scientifique sur le sujet « Sustained release tablets »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "Sustained release tablets"

Bhowmick, Argha, Arup Manna, Sanat Kumar Mandal, et al. "Formulation Development, Evaluation and Statistical Optimization of the Release Rate of Oral Sustained Release Matrix Tablet of Aceclofena." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 4 (2022): 6026–33. http://dx.doi.org/10.37285/ijpsn.2022.15.4.2.

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Aim: This work aimed to develop a sustained released hydrophilic matrix tablet of Aceclofenac for better therapeutic action.  Background: Conventional dosage form didn't provide the desired level of drug release. Even many-marketed sustained-release tablets didn't always meet the satisfactory level of drug release. It was a challenging job for pharmaceutical scientists to develop a well-sustained release formulation. Keeping this perspective in mind a robust sustained release formulation was designed, developed and optimized with nontoxic, inert viscoelastic, semisynthetic polymers which

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Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre

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Viswanath, V., U. Chandrasekhar, B. Narasimha Rao, and K. Gnana Prakash. "Development and evaluation of sustained release matrix tablets of losartan potassium." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 1, no. 04 (2016): 127–32. http://dx.doi.org/10.21477/ijapsr.v3i1.4858.

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The objective of the present study was to develop a sustained release matrix tablets of Losartan potassium, an anti hypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using different drug and polymer ratios. Hydrophilic natural polymers like xanthan Gum (XG), guar gum and cellulose were used. Compatibility of the drug with various excipients was studied. The compressed tablets were evaluated and showed compliance with Pharmacopoeial limits. Formulation was optimized (F2) on the basis of acceptable tablet properties and in vitro drug release. The re

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Karim, Samira, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Formulation and in vitro Evaluation of Glimepiride Sustained Release Tablets: Comparison with Immediate Release Tablets." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 157–62. http://dx.doi.org/10.3329/bpj.v18i2.24315.

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This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected t

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Thanh, Duyen Nguyen Thi, Duc Hoang Van, Minh Vo Xuan, Xuan Dam Thanh Thanh, and Tung Bui Thanh. "Design and Optimization of Hydrophilic Matrix-based Sustained Release Felodipine Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 3 (2018): 4136–44. http://dx.doi.org/10.37285/ijpsn.2018.11.3.8.

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Felodipine is a calcium channel blocker used for hypertensive and unstable angina treatments. The sustained release formulations of felodipine have advantages of achieving good therapeutic effects, increasing the bioavailability, decreasing dosing times per day and reducing side effects.The aim of our study was to study the formulation screening, then use an experiment design for formulating a hydrophilic matrix sustained release tablet of felodipine. Methods: The optimization process had the influences of the chosen excipients (including HPMC E4M, HPMC E15LV) on the drug release. Three depend

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Prof., Madhuri T. Deshmukh Ganesh Deokate *. Prof. R.V. Shete. "A REVIEW ON BILAYER TECHNOLOGY." Journal of Pharma Research 8, no. 3 (2019): 81–87. https://doi.org/10.5281/zenodo.2620324.

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ABSTRACT Over the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages of controlled drug delivery. Now a days greater attention has been focused on development of controlled & immediate release drug delivery systems. Bi-layer tablet is suitable for sequential release of two drugs in combination and also for sustained release of tablet in which one layer is for immediate release as loading dose and second layer is maintenance dose. S

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Taghizadeh Davoudi, Ehsan, Mohamed Ibrahim Noordin, Ali Kadivar, Behnam Kamalidehghan, Abdoreza Soleimani Farjam, and Hamid Akbari Javar. "Preparation and Characterization of a Gastric Floating Dosage Form of Capecitabine." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/495319.

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Gastrointestinal disturbances, such as nausea and vomiting, are considered amongst the main adverse effects associated with oral anticancer drugs due to their fast release in the gastrointestinal tract (GIT). Sustained release formulations with proper release profiles can overcome some side effects of conventional formulations. The current study was designed to prepare sustained release tablets of Capecitabine, which is approved by the Food and Drug Administration (FDA) for the treatment of advanced breast cancer, using hydroxypropyl methylcellulose (HPMC), carbomer934P, sodium alginate, and s

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Manish, Kumar Gupta, Ghadge Madhvi, Verma Sunil, and Singh Sudharshana. "FORMULATION AND EVALUATION OF BILAYER TABLETS FOR SUSTAINED RELEASE." International Journal of Current Pharmaceutical Review and Research 13, no. 3 (2021): 38–43. https://doi.org/10.5281/zenodo.12667170.

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Bi-layer tablet is a new era for successful development of controlled release formulationalong with various features to provide successful drug delivery. Bilayer layer tablets consistof two layers which are slow release and immediate release layers. It is an improvedtechnology to overcome the shortcoming of the single layer tablets and offer more benefits.The bilayer tablet helps to separate incompatible active pharmaceutical ingredient (APIs)from each other. Bilayer tablets material involves both the compressibility and consolidation.Bilayer formulations carry different drugs in each layer an

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Nnanyereugo, Chinelo Emmanuella, and Ogbonna Okorie. "Application of Acetylated Corn Starch as a Sustained Release Formulation in Metronidazole Tablets." Journal of Drug Delivery and Therapeutics 15, no. 5 (2025): 78–85. https://doi.org/10.22270/jddt.v15i5.7141.

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Objective(s): This study aimed to assess the impact of acetylation on the disintegrant properties of corn starch and evaluate its effectiveness as a sustained release formulation in metronidazole tablets. Design: Experimental study involving acetylation of corn starch using acetic anhydride. Intervention(s): Formulation of granules with varying concentrations of acetylated corn starch as disintegrant, followed by tablet production. Main Outcome Measure(s): Disintegration time, sustained release of metronidazole, tablet properties (friability, hardness, content uniformity), and release kinetics

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Gao, Lin, and Ye Wei. "Sustained Release Properties of Aminophylline Sustained Release Tablets Based on Exfoliated Graphite." Advanced Materials Research 1023 (August 2014): 67–70. http://dx.doi.org/10.4028/www.scientific.net/amr.1023.67.

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This study attempted to develop sustained release tablets based on exfoliated graphite. The in vitro evaluation of the prepared tablets was carried out to study its sustained release properties by means of UV/VIS spectroscopy. The results show that the release rate of aminophylline decreases with the increase of the content of graphite for the aminophylline sustained release tablets based on exfoliated graphite. The graphite in the aminophylline sustained release tablets will delay the release of aminophylline when the exfoliated graphite content in the sustained release tablets is less than 2

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Thèses sur le sujet "Sustained release tablets"

Khamanga, Sandile Maswazi Malungelo. "Formulation and assessment of verapamil sustained release tablets." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1018236.

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The oral route of drug administration is most extensively used due to the obvious ease of administration. Verapamil hydrochloride is a WHO listed phenylalkylarnine, L-type calcium channel antagonist that is mainly indicated for cardiovascular disorders such as angina pectoris, supraventricular tachycardia and hypertension. Due to its relatively short half-life of approximately 4.0 hours, the formulation of a sustained-release dosage form is useful to improve patient compliance and to achieve predictable and optimized therapeutic plasma concentrations. Direct compression and wet granulation wer

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Mwila, Chiluba. "The development and assessment of sustained release nevirapine tablets." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/54667.

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The use of antiretroviral (ARV) agents in the management of HIV/AIDS has significantly improved the lifestyle and wellbeing of patients. Despite the success that has been achieved with the use of ARV therapy, the occurrence of adverse effects and unpredictable bioavailability associated with most of these drugs remains a major concern. Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that is used in combination with other ARV compounds for the treatment of HIV-1 infections. It is also used for the prevention of mother to child transmission of the HIV-1 virus. NVP is

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Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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Hodsdon, Alison Claire. "Xanthan gum and sodium alginate as sustained-release carriers in hydrophilic matrix tablets." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259859.

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Kieser, Leith Faye. "Formulation and assessment of monolithic beta blocker sustained release tablets prepared by direct compression." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1003242.

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Beta blockers are commonly prescribed for the chronic treatment of hypertension, one of the most prolific disease states worldwide. The beta blockers selected for this study include acebutolol hydrochloride, labetalol hydrochloride, metoprolol tartrate oxprenolol hydrochloride and propranolol hydrochloride. All of these compounds have a short elimination half-life, necessitating multiple dose per day regimens and therefore the development of sustained release dosage forms incorporating these agents was considered beneficial in terms of extending the dosing interval, with the aim of improving p

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Pinto, Colin Andrew. "Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets." Thesis, University of the Sciences in Philadelphia, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10692987.

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The ability of chitosan and tripolyphosphate to form an ionic crosslinked material and its effectiveness in sustained release formulations has been reported. However, key issues commonly observed with these formulations include inefficiencies and inaccuracies in the drug loading as well as an inability to achieve complete release of drug. Acetaminophen, as a model drug, was added to various chitosan-tripolyphosphate crosslinked powders to assess the sustained release characteristics when drug is added extragranularly as opposed to during the crosslinking process, which is the most common p

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Avgoustakis, Konstantine. "Synthesis and evaluation of some poly(lactide-co-glycolides) for use in sustained release tablets." Thesis, King's College London (University of London), 1992. https://kclpure.kcl.ac.uk/portal/en/theses/synthesis-and-evaluation-of-some-polylactidecoglycolides-for-use-in-sustained-release-tablets(8b664ccc-71de-4a1c-8995-7b7f9c72e905).html.

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Gallardo, Alvarez Diego. "Manufacturing of matrix tablets by combining countercharged poly(meth)acrylate polymers to provide sustained release of highly soluble drugs." Göttingen Cuvillier, 2009. http://d-nb.info/993590594/04.

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Goole, Jonathan. "Développement et évaluation de mini-comprimés flottants à libération prolongée." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210505.

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Parmi toutes les voies d’administration, la voie orale a toujours suscité un grand intérêt. Les formes prises par voie orale présentent une grande facilité d’administration pour le patient, tandis que pour les chercheurs, la physiologie du système gastro-intestinal peut être facilement modélisable. Malheureusement, son importante variabilité, liée principalement au temps de vidange gastrique, peut conduire à une mauvaise reproductibilité des effets thérapeutiques et à une diminution de la biodisponibilité. Ce problème est surtout rencontré dans le cas des principes actifs présentant une fenêtr

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Elgaied-Lamouchi, Dhouha. "Découverte de nouveaux excipients pharmaceutiques à base d'amidons modifiés pour une libération prolongée d'une substance active." Thesis, Lille, 2020. https://pepite-depot.univ-lille.fr/.

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Les comprimés matriciels hydrophiles sont fréquemment utilisés pour contrôler la libération d’actif dans les formes galéniques à usage oral. Les amidons représentent un choix intéressant pour cette application. En effet, ce sont des matériaux biocompatibles, biodégradables et disponibles à partir de différentes sources végétales. En plus des amidons natifs, les amidons modifiés (AM) ont été beaucoup étudiés pour la formulation des comprimés matriciels à libération prolongée. Les modifications physico-chimiques peuvent être ajustées de manière à correspondre aux propriétés souhaitées pour une a

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Livres sur le sujet "Sustained release tablets"

Bhadra, Subrata. Nitroglycerin Sustained Release Tablet. Formulation Design and Evaluation. GRIN Verlag GmbH, 2013.

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Chapitres de livres sur le sujet "Sustained release tablets"

Ulmius, J., Z. G. Wagner, O. Borgå, and P. Wollmer. "Simultaneous Pharmacokinetic and in vivo Gamma Scintigraphic Monitoring in the Development of an Enprofylline-Sustained Release Tablet." In Drug Absorption at Different Regions of the Human Gastro-Intestinal Tract: Methods of Investigation and Results / Arzneimittelabsorption aus verschiedenen Bereichen des Gastrointestinaltraktes beim Menschen: Untersuchungsmethoden und Ergebnisse. Vieweg+Teubner Verlag, 1987. http://dx.doi.org/10.1007/978-3-322-91091-2_3.

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Awate, Pravin B., Mahesh K. Gupta, Dipak P. Kardile, Vishwas C. Bhagat, and Rajkumar V. Shete. "Design, In Vitro Evaluation of Sustained Release Matrix Tablet of Enalapril Maleate Employing Natural Polymer-Olibanum Gum and Its Resin Component." In Techno-Societal 2022. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-34648-4_47.

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"Factors affecting the formulation of sustained release potassium chloride tablets." In Pharmaceutical Technology: Controlled Drug Release Vol 2. CRC Press, 1991. http://dx.doi.org/10.3109/9780203979099-10.

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Saeed Jan, Muhammad, Waqas Alam, and Madeeha Shabnam. "Fundamentals Applications of Controlled Release Drug Delivery." In Drug Development and Safety [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.113283.

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The advancement of pharmacology and pharmacokinetics highlighted the important role of drug release kinetics in the determination of therapeutic outcomes of treatments. The advent of modified release dosage forms marked a significant innovation. Technological progressions in coating methods gained momentum in the late 1800s, encompassing innovations like sugar and enteric coatings applied to pills and tablets. Subsequent advancements led to the refinement of enteric coatings for tablets, which eventually evolved into the incorporation of a secondary drug within the sugar coating layer. However

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Panda, Simanchal. "Advanced Drug Delivery Systems: Formulating and Evaluating Metformin SR Tablets with Fenugreek Seed Mucilage." In Deep Science Publishing. Deep Science Publishing, 2025. https://doi.org/10.70593/978-81-984306-6-3.

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This book explores into the innovative formulation of metformin hydrochloride using fenugreek seed mucilage as a natural polymer. It bridges traditional botanical knowledge with modern pharmaceutical science to enhance the effectiveness and patient compliance of metformin, a key treatment for diabetes. The chapters meticulously detail the scientific process from raw material procurement to rigorous post-formulation evaluations, underlining our commitment to improving diabetic care through advanced drug delivery systems. By combining traditional fenugreek uses with contemporary pharmaceutical t

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Jabed, Akib, Maliha Rahman, and Md Enamul Hoque. "Rapid Prototyping in Biomedical Applications: Advanced Scopes, Capabilities and Challenges." In Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside (Part 2). BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815179330124010018.

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Rapid prototyping (RP) is an advanced technique of fabricating a physical model, or complex assembly where computer-aided design (CAD) plays a significant role. The RP technique offers numerous advantages including providing information such as how a product will look like and/or perform, and in the first stage of the design and manufacturing cycle, allowing switches and improvements to be implemented earlier in the system. It acts quickly and reduces the risk of later/final stage costly errors. RP is considered to be an automated and cost-effective technique as it does not require special too

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K, Dr Vijayareka. "EMERGING TRENDS IN DENTAL PHARMACOLOGY: NOVEL DRUG DEVELOPMENTS AND ADVANCEMENTS IN DRUG DELIVERY SYSTEMS FOR DENTAL PAIN MANAGEMENT." In Futuristic Trends in Medical Sciences Volume 3 Book 9. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bfms9p1ch5.

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The field of dental pharmacology has witnessed significant advancements in recent years, offering promising solutions to enhance dental pain management and patient care. This chapter explores the latest emerging trends in dental pharmacology, focusing on novel drug developments and advancements in drug delivery systems tailored to improve the efficacy, safety, and patient experience in dental pain management. Firstly, we delve into the realm of novel drug developments for dental pain management. Traditionally, the armamentarium of dental analgesics has relied on local anesthetics, nonsteroidal

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Latha, S. Madhavi, and P. Bharghava Bhushan. "Statistical Optimization and in Vitro Evaluation of Nizatidine Floating Tablets." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00586.

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Nizatidine is a histamine (H2) receptor antagonist that is indicated in the management of Gastric Esophageal Reflux Disorder, Peptic Ulcer Disease, gastric and duodenal ulcer. The bioavailabilty of Nizatidine is around 70% and the drug suffers from low permeability issues due to its hydrophilic nature. The aim of this work was to formulate and develop non effervescent floating matrix tablets of Nizatidine to increase the bioavailability of the drug by increasing gastric residence time. NEGFMT of Nizatidine were prepared using Glyceryl Laurate (GL), lactose, aerosol and magnesium stearate. 32 f

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Deshpande, A. H., and D. D. Wasule. "Design and Evaluation of Gastroretentive Ranitidine HCL Sustained Release Bilayer Tablet Using Wax Matrix: A Recent Study." In Highlights on Medicine and Medical Research Vol. 6. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/hmmr/v6/2373e.

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Kirsh, Kenneth L., Anya Kerith Vice, and Steven D. Passik. "History of Opioids and Opiophobia." In Pain and Chemical Dependency. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195300550.003.0001.

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Abstract Among the remedies which it has pleased Almighty God to give to man to relieve his sufferings, none is so universal and so efficacious as opium. The field of pain management has arrived at a crossroads in history with regard to the topic of opioid analgesics. Over the past several years, one of the most widely used opioid pharmaceuticals, OxyContin, had become a popular alternative to street drugs such as heroin. Called ‘‘Hillbilly Heroin’’ because of its popularity in Appalachia and other rural areas, it is available as an oral preparation, although illicit users tend to crush the ta

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Actes de conférences sur le sujet "Sustained release tablets"

Venkatesh, D. Nagasamy. "Design, development and evaluation of abacavir sustained release tablets." In Annual International Conference on Pharmaceutical Sciences and Pharmacology. Global Science & Technology Forum (GSTF), 2013. http://dx.doi.org/10.5176/2345-783x_pharma13.07.

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Li, Zao-hui, and Jiao Wang. "Studies on preparation of matrine solid dispersion sustained-release tablets." In 2017 2nd International Conference on Materials Science, Machinery and Energy Engineering (MSMEE 2017). Atlantis Press, 2017. http://dx.doi.org/10.2991/msmee-17.2017.40.

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Biswal, Swadhin Sekhar, Chandan Bhogendra Jha, Ayush Kumar, et al. "Evaluation of release-retarding potential of co-processed excipients on Quetiapine fumarate sustained release tablets." In THE FOURTH SCIENTIFIC CONFERENCE FOR ELECTRICAL ENGINEERING TECHNIQUES RESEARCH (EETR2022). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0162840.

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Gao, Lin, and Ye Wei. "Niclosamide Sustained Release Tablets with a Long-term Effect Based on Expanded Graphite." In 2nd Annual International Conference on Advanced Material Engineering (AME 2016). Atlantis Press, 2016. http://dx.doi.org/10.2991/ame-16.2016.78.

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Lefnaoui, Sonia, Samia Rebouh, Mounir Bouhedda, and M. Madiha Yahoum. "ANN Optimization Using Ant Colony Algorithm for Predicting the Valsartan Sustained Release from Polyelectrolyte Complexes Matrix Tablets." In 2019 International Conference on Applied Automation and Industrial Diagnostics (ICAAID). IEEE, 2019. http://dx.doi.org/10.1109/icaaid.2019.8934995.

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Surini, Silvia, Dina Risma Wati, and Rezi Riadhi Syahdi. "Preparation and characterization of cross-linked excipient of coprocessed xanthan gum-acacia gum as matrix for sustained release tablets." In 2ND BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2017. Author(s), 2018. http://dx.doi.org/10.1063/1.5023956.

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