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Thèses sur le sujet « Sustained release tablets »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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1

Khamanga, Sandile Maswazi Malungelo. "Formulation and assessment of verapamil sustained release tablets." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1018236.

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The oral route of drug administration is most extensively used due to the obvious ease of administration. Verapamil hydrochloride is a WHO listed phenylalkylarnine, L-type calcium channel antagonist that is mainly indicated for cardiovascular disorders such as angina pectoris, supraventricular tachycardia and hypertension. Due to its relatively short half-life of approximately 4.0 hours, the formulation of a sustained-release dosage form is useful to improve patient compliance and to achieve predictable and optimized therapeutic plasma concentrations. Direct compression and wet granulation wer

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Mwila, Chiluba. "The development and assessment of sustained release nevirapine tablets." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/54667.

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The use of antiretroviral (ARV) agents in the management of HIV/AIDS has significantly improved the lifestyle and wellbeing of patients. Despite the success that has been achieved with the use of ARV therapy, the occurrence of adverse effects and unpredictable bioavailability associated with most of these drugs remains a major concern. Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that is used in combination with other ARV compounds for the treatment of HIV-1 infections. It is also used for the prevention of mother to child transmission of the HIV-1 virus. NVP is

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Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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Hodsdon, Alison Claire. "Xanthan gum and sodium alginate as sustained-release carriers in hydrophilic matrix tablets." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259859.

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Kieser, Leith Faye. "Formulation and assessment of monolithic beta blocker sustained release tablets prepared by direct compression." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1003242.

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Beta blockers are commonly prescribed for the chronic treatment of hypertension, one of the most prolific disease states worldwide. The beta blockers selected for this study include acebutolol hydrochloride, labetalol hydrochloride, metoprolol tartrate oxprenolol hydrochloride and propranolol hydrochloride. All of these compounds have a short elimination half-life, necessitating multiple dose per day regimens and therefore the development of sustained release dosage forms incorporating these agents was considered beneficial in terms of extending the dosing interval, with the aim of improving p

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Pinto, Colin Andrew. "Development and Characterization of Chitosan Crosslinked with Tripolyphosphate as a Sustained Release Agent in Tablets." Thesis, University of the Sciences in Philadelphia, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10692987.

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<p> The ability of chitosan and tripolyphosphate to form an ionic crosslinked material and its effectiveness in sustained release formulations has been reported. However, key issues commonly observed with these formulations include inefficiencies and inaccuracies in the drug loading as well as an inability to achieve complete release of drug. Acetaminophen, as a model drug, was added to various chitosan-tripolyphosphate crosslinked powders to assess the sustained release characteristics when drug is added extragranularly as opposed to during the crosslinking process, which is the most common p

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Avgoustakis, Konstantine. "Synthesis and evaluation of some poly(lactide-co-glycolides) for use in sustained release tablets." Thesis, King's College London (University of London), 1992. https://kclpure.kcl.ac.uk/portal/en/theses/synthesis-and-evaluation-of-some-polylactidecoglycolides-for-use-in-sustained-release-tablets(8b664ccc-71de-4a1c-8995-7b7f9c72e905).html.

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8

Gallardo, Alvarez Diego. "Manufacturing of matrix tablets by combining countercharged poly(meth)acrylate polymers to provide sustained release of highly soluble drugs." Göttingen Cuvillier, 2009. http://d-nb.info/993590594/04.

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Goole, Jonathan. "Développement et évaluation de mini-comprimés flottants à libération prolongée." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210505.

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Parmi toutes les voies d’administration, la voie orale a toujours suscité un grand intérêt. Les formes prises par voie orale présentent une grande facilité d’administration pour le patient, tandis que pour les chercheurs, la physiologie du système gastro-intestinal peut être facilement modélisable. Malheureusement, son importante variabilité, liée principalement au temps de vidange gastrique, peut conduire à une mauvaise reproductibilité des effets thérapeutiques et à une diminution de la biodisponibilité. Ce problème est surtout rencontré dans le cas des principes actifs présentant une fenêtr

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10

Elgaied-Lamouchi, Dhouha. "Découverte de nouveaux excipients pharmaceutiques à base d'amidons modifiés pour une libération prolongée d'une substance active." Thesis, Lille, 2020. https://pepite-depot.univ-lille.fr/.

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Les comprimés matriciels hydrophiles sont fréquemment utilisés pour contrôler la libération d’actif dans les formes galéniques à usage oral. Les amidons représentent un choix intéressant pour cette application. En effet, ce sont des matériaux biocompatibles, biodégradables et disponibles à partir de différentes sources végétales. En plus des amidons natifs, les amidons modifiés (AM) ont été beaucoup étudiés pour la formulation des comprimés matriciels à libération prolongée. Les modifications physico-chimiques peuvent être ajustées de manière à correspondre aux propriétés souhaitées pour une a

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Nieto, Bobadilla Maria Susana. "A new antibacterial agent : in vitro bacteriological characterization and in vitro/in vivo performance of sustained release formulations." Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S018/document.

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Introduction : La résistance aux antibiotiques est une menace de santé, il est donc urgent de développer de nouveaux antibactériens. CIN-102, est un nouvel antibactérien développé par une industrie pharmaceutique. Il possède un large-spectre d’action et aucune résistance n’a été développée jusqu’à présent. Parmi les possibles applications thérapeutiques du CIN-102, notre recherche s’est focalisée sur les Maladies Inflammatoires Chroniques de l’Intestin (MICIs). Plusieurs facteurs contribuent à l’étiologie des MICIs. Les bactéries intestinales jouent un rôle important dans ces maladies et une a

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Chen, Wei-Yu, and 陳威羽. "Development of sustained-release persulfate tablets for groundwater remediation." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/25175765885421445504.

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碩士<br>國立暨南國際大學<br>土木工程學系<br>103<br>Persulfate possess oxidation ability, high solubility, long-time presence, good transmission capacity and regulation applicable to a wider range of features. In this study, the biodegradable hydroxypropyl methyl cellulose as a coating material, development of a sustained-release persulfate of green remediation tablets in groundwater. Through batch and column experiment assess release efficiency of persulfate about sustained-release presulfate tablet, with the type of cement persulfate release material were compared. This study aim is as follows: (1) assess re

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Lee, Pei-Ling, and 李珮玲. "Formulation study of T1-11 oral sustained release tablets." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/52874633216949528902.

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碩士<br>臺北醫學大學<br>生醫材料暨工程研究所<br>98<br>Huntington''s disease is still an incurable inherited disorder, and currently only symptomatic treatments are available. T1-11, a potential active ingredient for the treatment of Huntington’s disearse, is originally extracted from a traditional Chinese that can now be mass produced by chemical synthesis. Since patients with Huntington''s disease might have difficulties control their movements, thinking, and emotion, frequent drug dosing is not very convenient to the patients. Once per day of drug dosing that can ensure 24 hours of drug release would be ver

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Dhopeshwarkar, Vinayak Ramchandra. "Natural gums as matrix formers in sustained release pharmaceutical tablets /." 1991. http://www.gbv.de/dms/bs/toc/172745314.pdf.

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15

Chen, Shan-Chiung, and 陳善炯. "Formulation Studies on Sustained Release Formulations for Diclofenac Sodium Tablets." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/35875166440199717136.

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博士<br>國立臺灣大學<br>藥學系<br>85<br>Diclofenac sodium was used as the model drug in this formulation study that hydrophilic matrices were proposed for the sustained-release of the drug. HPC-M, HPC-H, HPMC 2910, and/or HPMC 2208 in different proportions were compared for the matrix material to regulate the sustained release. The matrix type tablets were prepared by adding lactose or wax as the additives and then compressed. The resulting tablets with different f

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Weng, Ling-Lun, and 翁翎倫. "Formulation design of tamsulosin hydrochloride orally disintegrating sustained-release tablets." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/25599816557485335781.

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Wu, Hai-Yao, and 吳海瑤. "Preparation and sustained release property of gastro-floating tablets of roselle extract." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7mkczx.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>106<br>Rosell calyxes are bright red due to their rich anthocyanin. Many studies have confirmed that anthocyanins have good antioxidant activity. They have many physiological functions such as anti-inflammatory, anti-tumor, anti-cancer, and protection of eyesight. At present, people are eagerly pursuing health foods, and more and more raw materials with physiological effects are used to develop a lot of health foods. Tablet is one of the common types of health foods, with advantages of small size, convenient carrying, low cost, etc. This experiment aims to devel

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Lee, Min-Chi, and 李明奇. "Preparation and Characterizations of Sustained-Released Drug Tablets." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/78411070866544793615.

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碩士<br>大葉大學<br>生物產業科技學系碩士在職專班<br>98<br>In Pharmaceutics, there are two common systems in making the oral Sustained-release tablets,i.e. Matrix system and Reservoir system. The polymers are used as materials in the two systems mostly, such as citosan、xanthan gum and hydroxypropylmethylcellulose (HPMC) etc. In reservoir system,using a fluid-bed spray granulator machine to sprinkle polymers on surface of tablet and forming a membrane. The membrane make drug's effect release slowly. In matrix system, using traditional method to form the tablets with the mixture by mixing the medicine with hydrogel

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19

Sundy, Erica. "A novel tablet design for zero-order sustained-release." Thesis, 2002. https://hdl.handle.net/10539/26107.

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Dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Medicine in the branch of Pharmacy<br>A coated doughnut-shaped tablet is evaluated as its ability to release model drugs at a zero-order rate for 8 to 12 hours. The doughnut-shape tablets were compressed using special designed punches.Automated technology is thus feasible for this system. The coating material , 10% w /w gelatin in HPMC K15M was directly compressed and adhered to the tablet core .<br>IT2018

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Rakkanka, Vipaporn. "A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet." Thesis, 2003. http://hdl.handle.net/1957/30894.

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21

Keller, Carol Ann. "Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients." Thesis, 2000. http://hdl.handle.net/1957/33246.

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Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5��g/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses and input rates for sustained release formulations of acetaminophen. Once parameters were selected from the simulations, sample formulations were prepared and tested using standard dissolution techniques. Investigations into dose/size relationships, hydroxyp

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22

Ahmed, Salah Uddin. "Development of oral sustained release tablet dosage forms for sparingly water soluble and highly water soluble drugs : physicochemical, biopharmaceutical and technological considerations /." 1989. http://www.gbv.de/dms/bs/toc/128347236.pdf.

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23

Domingues, Nabais Maria Teresa. "High-amylose carboxymethyl starch matrices for oral sustained drug-release : in vitro and in vivo evaluation." Thèse, 2013. http://hdl.handle.net/1866/10943.

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Les amidons non modifiées et modifiés représentent un groupe d’excipients biodégradables et abondants particulièrement intéressant. Ils ont été largement utilisés en tant qu’excipients à des fins diverses dans des formulations de comprimés, tels que liants et/ou agents de délitement. Le carboxyméthylamidon sodique à haute teneur en amylose atomisé (SD HASCA) a été récemment proposé comme un excipient hydrophile à libération prolongée innovant dans les formes posologiques orales solides. Le carboxyméthylamidon sodique à haute teneur en amylose amorphe (HASCA) a d'abord été produit par l'éthérif

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