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Articles de revues sur le sujet « Sustained release tablets »

Auteur : Grafiati

Publié le 2 juin 2025

Mis à jour le 31 juillet 2025

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1

Bhowmick, Argha, Arup Manna, Sanat Kumar Mandal, et al. "Formulation Development, Evaluation and Statistical Optimization of the Release Rate of Oral Sustained Release Matrix Tablet of Aceclofena." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 4 (2022): 6026–33. http://dx.doi.org/10.37285/ijpsn.2022.15.4.2.

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Aim: This work aimed to develop a sustained released hydrophilic matrix tablet of Aceclofenac for better therapeutic action.  Background: Conventional dosage form didn't provide the desired level of drug release. Even many-marketed sustained-release tablets didn't always meet the satisfactory level of drug release. It was a challenging job for pharmaceutical scientists to develop a well-sustained release formulation. Keeping this perspective in mind a robust sustained release formulation was designed, developed and optimized with nontoxic, inert viscoelastic, semisynthetic polymers which

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Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre

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Viswanath, V., U. Chandrasekhar, B. Narasimha Rao, and K. Gnana Prakash. "Development and evaluation of sustained release matrix tablets of losartan potassium." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 1, no. 04 (2016): 127–32. http://dx.doi.org/10.21477/ijapsr.v3i1.4858.

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The objective of the present study was to develop a sustained release matrix tablets of Losartan potassium, an anti hypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using different drug and polymer ratios. Hydrophilic natural polymers like xanthan Gum (XG), guar gum and cellulose were used. Compatibility of the drug with various excipients was studied. The compressed tablets were evaluated and showed compliance with Pharmacopoeial limits. Formulation was optimized (F2) on the basis of acceptable tablet properties and in vitro drug release. The re

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Karim, Samira, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Formulation and in vitro Evaluation of Glimepiride Sustained Release Tablets: Comparison with Immediate Release Tablets." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 157–62. http://dx.doi.org/10.3329/bpj.v18i2.24315.

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This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected t

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Thanh, Duyen Nguyen Thi, Duc Hoang Van, Minh Vo Xuan, Xuan Dam Thanh Thanh, and Tung Bui Thanh. "Design and Optimization of Hydrophilic Matrix-based Sustained Release Felodipine Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 3 (2018): 4136–44. http://dx.doi.org/10.37285/ijpsn.2018.11.3.8.

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Felodipine is a calcium channel blocker used for hypertensive and unstable angina treatments. The sustained release formulations of felodipine have advantages of achieving good therapeutic effects, increasing the bioavailability, decreasing dosing times per day and reducing side effects.The aim of our study was to study the formulation screening, then use an experiment design for formulating a hydrophilic matrix sustained release tablet of felodipine. Methods: The optimization process had the influences of the chosen excipients (including HPMC E4M, HPMC E15LV) on the drug release. Three depend

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Prof., Madhuri T. Deshmukh Ganesh Deokate *. Prof. R.V. Shete. "A REVIEW ON BILAYER TECHNOLOGY." Journal of Pharma Research 8, no. 3 (2019): 81–87. https://doi.org/10.5281/zenodo.2620324.

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<strong><em>ABSTRACT</em></strong> <strong><em>O</em></strong><em>ver the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages of controlled drug delivery. Now a days greater attention has been focused on development of controlled & immediate release drug delivery systems. Bi-layer tablet is suitable for sequential release of two drugs in combination and also for sustained release of tablet in which one layer is for immediate release as loading dose and second layer is maintenance dose. S

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Taghizadeh Davoudi, Ehsan, Mohamed Ibrahim Noordin, Ali Kadivar, Behnam Kamalidehghan, Abdoreza Soleimani Farjam, and Hamid Akbari Javar. "Preparation and Characterization of a Gastric Floating Dosage Form of Capecitabine." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/495319.

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Gastrointestinal disturbances, such as nausea and vomiting, are considered amongst the main adverse effects associated with oral anticancer drugs due to their fast release in the gastrointestinal tract (GIT). Sustained release formulations with proper release profiles can overcome some side effects of conventional formulations. The current study was designed to prepare sustained release tablets of Capecitabine, which is approved by the Food and Drug Administration (FDA) for the treatment of advanced breast cancer, using hydroxypropyl methylcellulose (HPMC), carbomer934P, sodium alginate, and s

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Manish, Kumar Gupta, Ghadge Madhvi, Verma Sunil, and Singh Sudharshana. "FORMULATION AND EVALUATION OF BILAYER TABLETS FOR SUSTAINED RELEASE." International Journal of Current Pharmaceutical Review and Research 13, no. 3 (2021): 38–43. https://doi.org/10.5281/zenodo.12667170.

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Bi-layer tablet is a new era for successful development of controlled release formulationalong with various features to provide successful drug delivery. Bilayer layer tablets consistof two layers which are slow release and immediate release layers. It is an improvedtechnology to overcome the shortcoming of the single layer tablets and offer more benefits.The bilayer tablet helps to separate incompatible active pharmaceutical ingredient (APIs)from each other. Bilayer tablets material involves both the compressibility and consolidation.Bilayer formulations carry different drugs in each layer an

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Nnanyereugo, Chinelo Emmanuella, and Ogbonna Okorie. "Application of Acetylated Corn Starch as a Sustained Release Formulation in Metronidazole Tablets." Journal of Drug Delivery and Therapeutics 15, no. 5 (2025): 78–85. https://doi.org/10.22270/jddt.v15i5.7141.

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Objective(s): This study aimed to assess the impact of acetylation on the disintegrant properties of corn starch and evaluate its effectiveness as a sustained release formulation in metronidazole tablets. Design: Experimental study involving acetylation of corn starch using acetic anhydride. Intervention(s): Formulation of granules with varying concentrations of acetylated corn starch as disintegrant, followed by tablet production. Main Outcome Measure(s): Disintegration time, sustained release of metronidazole, tablet properties (friability, hardness, content uniformity), and release kinetics

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Gao, Lin, and Ye Wei. "Sustained Release Properties of Aminophylline Sustained Release Tablets Based on Exfoliated Graphite." Advanced Materials Research 1023 (August 2014): 67–70. http://dx.doi.org/10.4028/www.scientific.net/amr.1023.67.

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This study attempted to develop sustained release tablets based on exfoliated graphite. The in vitro evaluation of the prepared tablets was carried out to study its sustained release properties by means of UV/VIS spectroscopy. The results show that the release rate of aminophylline decreases with the increase of the content of graphite for the aminophylline sustained release tablets based on exfoliated graphite. The graphite in the aminophylline sustained release tablets will delay the release of aminophylline when the exfoliated graphite content in the sustained release tablets is less than 2

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Ravindra, K. Patil* Kundan. P. Chaudhari Bharat W. Tekade Umesh T. Jadhao Vijay. R. Patil. "FORMULATION AND EVALUATION OF ATENOLOL SUSTAINED RELEASE TABLETS BY USING NATURAL POLYMERS." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2627–34. https://doi.org/10.5281/zenodo.858675.

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The aim of present study was to develop sustained release tablet of atenolol by using natural polymers. Physicochemical properties of gum Moringa oleifera was studied like loss on drying, pH,viscocity, Sustained tablet of atenolol was prepared by using gum Moringa oleifera, Gaur Gum, Xanthan Gum in various concentrations by direct compression using 8 mm concave punch. Precompresion parameter was studied. All the observations are within the prescribed limits. Prepared Atenolol tablets were evaluated for post compression parameters which are in acceptable ranges. The drug content of the tablets

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Wagh, Vijay D., and Nilesh Pawar. "Development and Evaluation of Sustained Release Tablet of Betahistine Hydrochloride Using Ion Exchange Resin Tulsion T344." ISRN Pharmaceutics 2012 (June 18, 2012): 1–5. http://dx.doi.org/10.5402/2012/438342.

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An attempt was made to sustain the release of Betahistine hydrochloride by complexation technique using strong cation-exchange resin, Tulsion T344. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, swelling time, ratio of drug : resin, and temperature. The resinate was evaluated for micromeritic properties and characterized using XRPD and IR. For resinate sustained release tablets were formulated using hydoxypropyl methylcellulose K100M. The tablets were evaluated for hardness, thickness, friability, drug content, weight variation, and in vitro d

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Rahman, Md Ziaur, Sayed Koushik Ahamed, Sujan Banik, and Mohammad Salim Hossain. "Release Profile of Losartan Potassium from Formulated Sustained Release Matrix Tablet." Bangladesh Pharmaceutical Journal 16, no. 2 (2015): 177–83. http://dx.doi.org/10.3329/bpj.v16i2.22301.

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The present study was undertaken to develop sustained release (SR) matrix tablets of Losartan potassium, an angiotensin-II antagonist for the treatment of hypertension. The tablets were prepared by direct compression method along with Kollidon SR and Methyl Cellulose as release retardant polymers. The evaluation involves two stages- the physical properties studies of tablets and in vitro release kinetics assessment. The USP paddle method was selected to perform the dissolution test and 900 ml phosphate buffer of pH 6.8 was used as dissolution medium at 50 rpm at 370C. The release kinetics were

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NIZAMI, FARIDA, and YOGENDRA MALVIYA. "RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW." Current Research in Pharmaceutical Sciences 11, no. 4 (2022): 91–97. http://dx.doi.org/10.24092/crps.2021.110401.

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Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermin

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Madhu, Rajak*, Amal Raj A., Singh Dhakad Rajendra, and Singh Rajput Hakim. "FORMULATION AND EVALUATION OF BILAYER TABLET OF ANTIHYPERTENSIVE DRUG." World Journal of Pharmaceutical Science and Research 3, no. 5 (2024): 440–53. https://doi.org/10.5281/zenodo.14050790.

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The aim of present study is to prepare bilayer tablets of Losartan Potassium with an immediate release and a sustained release layer. The immediate release layer was prepared using super disintegrant sodium starch glycolate and sustained release layer is formulated with different polymers. The bilayer tablets of losartan potassium were prepared by the direct compression method. The drug, polymers and other excipients used for both immediate (IR) and sustained release (SR) layers were passed through sieve #80 before their use in the formulation. The immediate dose of drug was calculated from to

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Dr., N. Sandeepthi *and Dr. L. Satyanarayana. "FORMULATION AND EVALUATION OF NAPROXEN SUSTAINED RELEASE MATRIX TABLET." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1498–510. https://doi.org/10.5281/zenodo.1204477.

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The present investigation is concerned with development and evaluation of Sustained release matrix tablets containing Naproxen using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC K100M & HPMC K4M).Preformulation study was done initially which include characterization of polymers, drug identification, FTIR compatibility and result directed for the further course of formulation. The tablets were prepared by direct compression method and evaluation done. Tablets were compressed by tablet compression machine (Karnavati Rimek Mini press1)and evaluated with different parameters l

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Okafo, Sinodukoo Eziuzo, Phillips Oghenerhivwe Monioro, Perpetual Ogochukwu Enyaosah, and Amarachi Offor. "Formulation and Evaluation of Sustained Release Tablet of Metformin by Ionic Gelation Technique using Sida acuta Gum as Release Retardant." Journal of Drug Delivery and Therapeutics 13, no. 5 (2023): 22–28. http://dx.doi.org/10.22270/jddt.v13i5.5804.

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This research was done to formulate and assess the sustained release property of metformin tablets prepared from metformin microcapsules produced by ionic gelation technique using Sida acuta gum or sodium carboxymethylcellulose as release retardant. Sida acuta gum was produced by isopropyl alcohol precipitation of the filtrate obtained from distilled water maceration of powdered dried Sida acuta leaves. Metformin and Sida acuta gum compatibility was determined using FTIR. Metformin microcapsules were prepared by ionic gelation technique using sodium alginate alone or with either Sida acuta gum

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Kumar Halwai, Satish, and Jay Narayan Mishra. "FORMULATION, DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE TABLET OF ACECLOFENAC." International Journal of Advanced Research 11, no. 08 (2023): 592–97. http://dx.doi.org/10.21474/ijar01/17425.

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In this study, sustained-release (SR) tablets of Aceclofenac were developed using acrypol 971Pas polymers. The tablets were prepared by mixing the active drug (Aceclofenac) with the polymer and other excipients, and then compressing the mixture into tablets using a tablet press.The release profile of the SR tablets was optimized by adjusting the ratios of the polymers and other excipients. The optimized formulation showed sustained release of the drug up to 16 hours, and the release kinetics followed first-order models. The tablets were stored under various conditions (e.g., at different tempe

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Sahoo, S. K., A. Behera, and S. Patil. "FORMULATION AND EVALUATION OF LEVOFLOXACIN HEMIHYDRATE SUSTAINED RELEASE TABLET FROM HYDROPHILIC MATRICES." INDIAN DRUGS 49, no. 01 (2012): 43–49. http://dx.doi.org/10.53879/id.49.01.p0043.

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Stable sustained release tablets of levofloxacin hemihydrate were successfully prepared by wet granulation technique. Compatible excipients were selected and different formulations were prepared with varying proportion and grades of hydroxy propyl methyl cellulose. Tablets were prepared by compressing free flowing granules and evaluated for hardness, thickness, friability, weight variation, percentage drug content and drug release. As concentration of HPMC increased the drug release decreased might be due to increased amount of polymer around tablets provided gelation which inhibits the releas

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Changder, Abhijit, Riyasree Paul, Ananya Ghosh, Arup Manna, Gouranga Nandi, and Lakshmi Kanta Ghosh. "Fabrication and Evaluation of Aceclofenac-loaded Sustained-Release Mucoadhesive Tablet Composed of Cassia fistula Seed Gum-Grafted-Poly (Sodium Acrylate)." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 2 (2023): 6407–20. http://dx.doi.org/10.37285/ijpsn.2023.16.2.3.

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Aim: This study was aimed to fabricate gastroretentive mucoadhesive sustained-release tablets of aceclofenac with Cassia fistula seed gum-grafted-poly(sodium acrylate) and evaluate them. Background: Aceclofenac has several gastric related side effects such as increase in acid secretion, gastritis, burning sensation, nausea, vomiting, etc. Sustained-release tablet may reduce these because of slow drug release. But long term use of conventional sustained-release tablets of NSAIDs showed to develop colorectal ulcer. Gastroretentive sustained-release devices may eliminate this problem.

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Wanda B. Putri, Friesca S. Nurhaidah, Helmy Yusuf, and Maria L.A.D. Lestari. "Pengaruh Desain Punch Terhadap Mutu Fisik dan Disolusi Tablet MUPS Metformin HCl." MEDICINUS 36, no. 3 (2023): 36–47. http://dx.doi.org/10.56951/af7svb90.

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The compaction of multi-unit pellet system (MUPS) into tablets is a potential alternative for sustained release drugs. Tableting tools (punch and die) affect the compaction process and quality of MUPS tablets. The punch design intends to preserve the desired drug release of compacted pellets. This study aims to investigate the effect of two punch shapes, the flat face radius edge (FFRE) and concave-faced punch (concave), each at two different cup depths, on the physical properties and release profile of metformin HCl MUPS tablets. Drug release parameters, t50 values, showed that the metformin

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Fazli, Abdul Aala, Taha Umair Wani, Syed Naiem Raza, Khalid Bashir Mir, and Nisar Ahmad Khan. "Formulation and Evaluation of Sustained release tablets of Venlafaxine HCl." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 285–89. http://dx.doi.org/10.22270/jddt.v9i3-s.2842.

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The aim of the present study was to develop a tablet formulation for sustained release of venlafaxine HCl. Control or sustained release formulations have great applications in improving the physicochemical properties and the pharmacokinetic profile of the drugs. Carbopol tablets containing venlafaxine HCl were developed successfully by wet granulation technique. The tablets were evaluated for matrix integrity and drug release in 0.1 N HCl using USP II dissolution apparatus maintained at optimum conditions. The developed tablets were robust and possessed excellent physicochemical properties. Th

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Kumar, Deepak, ,. Archana, and Abadhesh Kumar Niranjan. "A Comprehensive Review on Sustained Release Matrix Drug Delivery System." Journal of Drug Delivery and Therapeutics 12, no. 4-S (2022): 249–53. http://dx.doi.org/10.22270/jddt.v12i4-s.5540.

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Formulations for sustained medication release are very useful in the treatment of chronic disorders. The oral route has selected matrix tablets as the most likely type of prolonged drug release. In order to generate therapeutic activity for a protracted duration, matrix tablets maintain a stable plasma drug concentration and sustain the rate of release of the drug throughout time. In preparations with a short half-life and high dosage frequency, extended-release is crucial. The matrix regulates how quickly the medication is released. Retardants such polyglycolic acid, polymethyl methacrylate,

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Poornima, Agrawal, Bundela Ragini, Shukla Karunakar, Jain Gaurav, and Singh Jaydeep. "Formulation And Evaluation Of Sustained Release Tablets Of Sitagliptin." International Journal of Research Publication and Reviews 6, no. 6 (2025): 4803–8. https://doi.org/10.55248/gengpi.6.0125.0642.

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Gangurde, Gayatri* Dhum Manohar Gavali Prashant Sonawane Mitesh. "Review on Bilayer Tablets." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1192–203. https://doi.org/10.5281/zenodo.15019244.

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Bi-layer tablets are essential for developing both immediate and modified drug delivery systems for various diseases. They facilitate controlled medication release, representing a significant advancement in Controlled Drug Delivery Systems (CDDS) and improving the effectiveness of medication delivery. Over the past 30 years, the complexity and costs of introducing new drugs have increased, leading to greater focus on sustained or controlled release systems. Bi-layer tablets enable precise delivery of medications with predetermined release profiles, preventing chemical incompatibilities between

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Satyajit, Panda, Mishra Bibaswan, and Behera Swayamprava. "Bi-Layer Tablets: An Emerging State of Art Technology in Dosage Form Design." Journal of Advances in Nanotechnology and its Applications 3, no. 2 (2021): 1–14. https://doi.org/10.5281/zenodo.5515151.

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<em>Despite significant advancements in dosage form design, oral route still remains the most favoured route of drug administration. Even now-a-days tablets have got more attention compared to other dosage forms because of simple, inexpensive, greater stability and most suitable nature of tablets. More recently major considerations in tablet sector have been focused on development of controlled and immediate release drug delivery systems. Many pharmaceutical manufacturers are giving more emphasis to bi-layer tablet sector now a day, because of several advantages like extension of patent, impro

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Samrudh, Shinde Shivaji Patil Namrata Satkar Pritam Salokhe Nilesh Chougule. "Formulation And Evaluation Of Floating Sustain Release Tablet Of Ranolazine." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1505–16. https://doi.org/10.5281/zenodo.12788828.

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This research focuses on the formulation and evaluation of floating sustained-release tablets of Ranolazine, an anti-anginal agent with poor bioavailability and short half-life. The tablets were prepared using various polymers such as hydroxypropyl methylcellulose (HPMC) and sodium alginate to achieve controlled drug release and prolonged gastric residence time. The formulation was optimized using a 32 full factorial design to study the effect of independent variables like polymer concentration and tablet hardness on drug release kinetics and floating behavior. The prepared tablets exhibited e

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Garg, Ayush, and Amul Mishra. "Formulation and Evaluation of Indapamide Hemihydrate Sustained Release Tablets." Asian Pacific Journal of Health Sciences 9, no. 1 (2022): 30–36. http://dx.doi.org/10.21276/apjhs.2022.9.1.08.

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The aim of the study is to formulate and to evaluate the indapamide SR tablet for the treatment of hypertension. Literature survey shows that indapamide is an anti-hypertensive and diuretic drug. The drug has been released up to 6–15 h, after taken orally. These tablets are absorbed into the systemic circulation and blood level shows the considerable peak of drug. It has been formulated as sustained release form for the betterment of therapeutic index and for maintaining constant blood levels. From the study, it has been concluded that HPMC shows the best results for the extending the release

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Swetanshu, ,., and Vijay Sharma. "Formulation, Optimization and Evaluation of Bilayer Tablet of Antihypertensive Drug." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 704–8. http://dx.doi.org/10.22270/jddt.v9i4.3098.

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Hypertension or high blood pressure occurs when the high cardiac output exerts pressure on the arterial wall as the blood flow increases. Bi-layer tablets are prepared with one layer of drug for immediate release while second layer designed to release drug later, either as second dose or in an extended release manner. Bi-layered tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances, and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is suitable f

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Gawai, Nitin, and Zahid Zaheer. "FORMUALTION AND DEVELOPMENT OF MUCOADHESIVE SUSTAINED RELEASE BUCCAL TABLETS AND PATCHES OF 5-FLUOROURACIL USING DIFFERENT POLYMERS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 174. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.20241.

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Objective: The present research study was undertaken to formulate mucoadhesive sustained release buccal tablets and patches of 5-fluorouracil (5-FU).Method: For the research experiment work design expert software version 10, stat-ease, Inc. has been used. A 32 full factorial design was selected for the formulation of the buccal tablet as well as buccal patches. In this research work, formulated tablets and patches using different polymers such as carbopol 974p, polyvinylpyrrolidone-K 30, sodium deoxycholate, microcrystalline cellulose, and polyvinyl alcohol. An after formulation of batches for

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Kumari, Satish, Anchal Puri, Dhruv Dev, DN Prasad, and ,. Monika. "A review on polymers in natural or modified form used in sustained release tablet." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 870–73. http://dx.doi.org/10.22270/jddt.v9i3-s.2843.

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Tablet is a solid dosage form which is used to deliver the drug to the body to make pharmacological action. The oral dosage form should disperse into small particles to deliver active ingredients in the body, the disperse time of the dosage form depends on the ingredients which are used in the tablet. To make the tablet disintegrate slow usually sustained release agents are used. The sustained release tablets helps in maintaining the drug concentration in the body for the higher time. In this review article various polymers of natural origin and their modified forms are studied, which can be u

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Singh, Neha, Durga Pandey, Nilesh Jain, and Surendra Jain. "Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 23–31. http://dx.doi.org/10.22270/jddt.v11i1.4481.

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The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24

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Tarizza Puspa Anggrelia, Amelia Saputri Ginting, Yeka Khafidz Illa Rosyidah, et al. "Kajian Penggunaan Matriks Pada Formulasi Tablet Lepas Lambat." Jurnal Anestesi 2, no. 3 (2024): 251–60. http://dx.doi.org/10.59680/anestesi.v2i3.1249.

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This research discusses the use of matrices in sustained-release tablet formulations to optimize the active substance release profile. Extended-release tablets are a type of tablet formulation designed to release the active substance gradually in the body over a certain period of time. The main purpose of sustained-release tablets is to maintain drug levels in the blood or target area over a longer period of time, compared to conventional tablets which release the active substance quickly after ingestion. The method used in this research is a qualitative approach which aims to deepen an in-dep

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Das, Urmi, and Mohammad Salim Hossain. "Effects of release modifier on Carvedilol release from Kollidon SR based matrix." International Current Pharmaceutical Journal 1, no. 8 (2012): 186–92. http://dx.doi.org/10.3329/icpj.v1i8.11248.

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Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcry

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Deshpande, Amar H., and Wasul D. "DESIGN AND EVALUATION OF FOOD GRADE WAX MATRIX SUSTAINED RELEASE MINI-TABLETS OF MONTELUKAST SODIUM." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 317. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16788.

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Objective: The objective of this study is to formulate a tablet that fits in the size range of mini-tablets using wax matrix forming substances, allowsvariation of drug dose and study of drug release kinetics of the dosage form.Methods: The blends of drug with glyceryl monostearate, purified rice bran wax and carnauba wax that renders the waxes food grade, were preparedand evaluated for precompression characteristics. The blends were compressed into mini-tablets having desirable physical characteristics andwere subjected to tests such as weight variation and friability. The tablets were subjec

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Kalyani Shelar, Gauri Mahajan, Nikita Pagare, Prachiti Sahane, and Sakshi Bhosale. "Review on Sustained Release Tablet." International Journal of Scientific Research in Science and Technology 11, no. 6 (2024): 698–708. https://doi.org/10.32628/ijsrst241161126.

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This review highlights the advantages of SR formulations, including reduced side effects, enhanced drug utilization, improved treatment efficacy, and better patient compliance. Key considerations for developing sustained release tablet involve the drug's physicochemical properties and biological factors, such as absorption and metabolism. Various formulation strategies, including diffusion-controlled, dissolution-controlled, and osmotic systems, are discussed alongside essential evaluation parameters like density, hardness, and in-vitro drug release profiles. The outlook for sustained release

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D., Aswani1* M. Bhagyasree2. "Formulation And Evaluation Of Tranexamic Acid Sustained Release (Sr) Tablets." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 1381–419. https://doi.org/10.5281/zenodo.13854247.

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The aim of the present study was to formulate and evaluate sustained release tablets of tranexamic acid. Xanthan gum and Guar gum were used as release rate controlling polymers. The prepared formulation mixtures were evaluated for preformulation parameters like bulk density, tapped density, angle of repose, Carr’s index and Hausner’s ratio. All the drug mixtures have shown the results within the limits. FTIR studies revealed that there are no incompatibilities among the formulation ingredients. The post compression parameter results of all the prepared tablets were found to be with

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S. Jat, Deepak, Swati G. Talele, Akshada A. Bakliwal, and Anil G. Jadhav. "DESIGN, DEVELOPMENT AND EVALUATION OF ALOGLIPTIN AND METFORMIN HYDROCHLORIDE BILAYER TABLET." Indian Drugs 59, no. 07 (2022): 74–76. http://dx.doi.org/10.53879/id.59.07.12280.

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The objective of the present work was to formulate and evaluate bilayer tablets of alogliptin and metformin HCl. Combining alogliptin with metformin HCL gives additional benefits in comparison with either drug alone and could be considered for patients whose quality of life is impaired by diabetes mellitus. The study was performed to design bilayer tablets of alogliptin immediate release layer and metformin HCl sustained release layer by wet granulation method. The immediate release layer comprised Crospovidone superdisintegrant and sustained release layer comprised HPMC K4M as rate release co

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Sanghavi, N. M., P. R. Kamath, and D. S. Amin. "Sustained Release Tablets of Theophylline." Drug Development and Industrial Pharmacy 16, no. 11 (1990): 1843–48. http://dx.doi.org/10.3109/03639049009025791.

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Elsayed, Mahmoud M. A., Moustafa O. Aboelez, Mohamed S. Mohamed, et al. "Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study." Pharmaceutics 14, no. 8 (2022): 1629. http://dx.doi.org/10.3390/pharmaceutics14081629.

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Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The purpose of this study is to make rosuvastatin calcium (ROS) and atenolol (AT) bilayer tablets to treat coexisting dyslipidemia and hypertension with a single product. ROS was chosen for the immediate-release layer of the constructed tablets, whereas AT was chosen for the sustained-release layer. The solid dispersion of ROS with sorbitol (1:3 w/w) was utilized in the immediate-release layer while hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC), and sodium bicarbonate were incorporated into th

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K., Srinivasa Reddy Surya Kanta Swain K. P. R. Chowdary *. and S.V.U.M. Prasad. "FORMULATION DEVELOPMENT OF SUSTAINED RELEASE FLOATING TABLETS OF VALSARTAN: OPTIMIZATION BY 22 FACTORIAL DESIGN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 06 (2018): 6023–29. https://doi.org/10.5281/zenodo.1303394.

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The objective of the present study is optimization of valsartan SR floating tablet formulation by 22 factorial design. SR floating tablets of valsartan (80 mg) were formulated employing HPMCK100M as matrix forming polymer, sodium bicarbonate as gas generating agent and beeswax and ethyl cellulose as floating enhancers. Valsartan is an orally active anti-hypertensive drug, majorly absorbed from stomach and upper small intestine. Formulation of sustained release floating tablets of valsartan is needed because of its poor oral bioavailability and short biological half-life. Valsartan floating tab

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Permata Hati, Melati, Yandi Syukri, and Bambang Hernawan Nugroho. "Pengaruh Kombinasi Matriks terhadap Karakter Tablet Metformin HCl Lepas Lambat Sistem Floating Effervescent." Pharmaceutical Journal of Indonesia 7, no. 2 (2022): 89–96. http://dx.doi.org/10.21776/ub.pji.2022.007.02.3.

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The research aimed to prepare and evaluate of sustained release metformin HCl tablet with floating system. The tablets were prepared by wet granulation using HPMC K4M and chitosan as matrixes with proportions (w/w) 17.78%:4.44%; 14.44%:7.78%; 11.11%:11.11% ;7.78%;14.44%; 4.44%:17.78%. The tablets were evaluated of weight variation, drug content, hardness, friability, and in vitro floating and drug release studies. The dissolution study had been carried out for 6 hours using USP dissolution apparatus II (paddle) in 900 ml HCl pH 3.0 media at 37±0.50C. All tablet formulas showed closed similarit

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Ujjwal, Kukreti, Nainwal Nidhi, Ale Yogita, et al. "Release Kinetic of Sustained Release Matrix Tablet of Linezolid Containing Polymer Blend." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1479–84. http://dx.doi.org/10.25258/ijpqa.15.3.60.

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Tuberculosis (TB) is a bacterial infection mainly affecting the lungs. TB is a major health problem worldwide and the occurrence of extensively drug-resistant TB (XDR-TB) and multidrug-resistant TB (MDR-TB) offers considerable hurdles to effective treatment and disease management. The growth of treatment-resistant Mycobacterium TB strains has prompted the investigation of alternate therapeutic techniques, including the application of sustained drug delivery. Sustained-release drugs reduce the need for frequent dosing can extend the effects of linezolid by 8 to 12 hours, thus improving the pati

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Okafo, Sinodukoo E., John A. Avbunudiogba, and Ejiro Ejomafuvwe. "Formulation and evaluation of sustained release diclofenac sodium matrix tablets produced using Brachystegia eurycoma gum." Journal of Pharmacy & Bioresources 17, no. 1 (2020): 34–43. http://dx.doi.org/10.4314/jpb.v17i1.7.

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This study was carried out to evaluate sustained release diclofenac sodium matrix tablets formulated using Brachystegia eurycoma gum (BEG) as matrix polymer. BEG was isolated by acetone -precipitation of the filtrate obtained from the maceration of powdered dried seeds of Brachystegia eurycoma in distilled water. Diclofenac sodium matrix tablets were produced by non-aqueous wet granulation method using BEG as the hydrophilic matrix former. The tablets were evaluated using official and unofficial tests such as; uniformity of weight, content uniformity, dissolution test, tablets diameter, thickn

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Agam, Kumar Chaubey* Ashok Baghel Dinesh Sharma Yogendra Singh. "Formulation And Evaluation of Bi-Layered Tablet of Divalproex Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 501–13. https://doi.org/10.5281/zenodo.14993024.

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The pharmacokinetic advantage relies on the criterion that, drug release from the fast-releasing layer leads to a sudden rise in the blood concentration. However, the blood level is maintained at steady state as the release from sustained layer. Particularly bilayer tablets are commonly used to avoid chemical incompatibilities of formulation components by physical separation, and release profile. The tablet is the most widely used dosage form because of its convenience in terms of self-administration, compactness and ease in manufacturing.4 Tablets are solid dosage forms containing medicinal s

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Ankit, Singh* Rajesh Gour** &. Akhlesh Kumar Singhai***. "MODIFIED RELEASE OF MEDICATION DELIVERY: A REVIEW." International Journal of Scientific Research and Modern Education (IJSRME) 8, no. 1 (2023): 33–41. https://doi.org/10.5281/zenodo.7806086.

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In terms of drug delivery methods, the oral route is the most popular. However, the traditional dosage form has a few drawbacks that could be fixed by altering the current dosage form. A regulated and sustained drug delivery system prolongs the duration of action by slowing the drug's release rate and maintaining a consistent plasma drug concentration. The matrix tablet is a crucial tool among the numerous formulation options for sustained release tablets. This makes issues like poor patient compliance, multiple doses, and see-saw oscillations simply manageable. A number of hydrophilic or

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BANSAL, MAYANK, and RAKESH GUPTA. "Bilayer Tablet a Dual Released, an Emerging Trend for Novel Drug Delivery System." Indian Journal of Health Care, Medical & Pharmacy Practice 4, no. 2 (2023): 46–70. http://dx.doi.org/10.59551/ijhmp/25832069/2023.4.2.50.

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Bilayer tablets are a kind of medication that effectively treats illness by combining two pharmaceuticals, either the same or different ones, in a single dosage. Physically separating active pharmaceutical ingredients (API) may prevent chemical incompatibilities, and bilayer tablets can pave the way for the creation of various drug release profiles, such as immediate and prolonged release. Analgesic and anti-inflammatory bilayer tablets are significantly different. Two medications may be sequentially released from a bi-layer tablet, making it ideal for sustained-release tablets. One layer can

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Nikolic, Nenad, Djordje Medarevic, Svetlana Ibric, and Zorica Djuric. "Evaluation of formulation and effects of process parameters on drug release and mechanical properties of tramadol hydrocloride sustained release matrix tablets." Chemical Industry 69, no. 5 (2015): 503–10. http://dx.doi.org/10.2298/hemind140317069n.

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This study investigates using of high molecular weight polyethylene oxide (PEO WSR Coagulant) for the preparation of sustained release matrix tablets containing high dose, highly water soluble drug, tramadol HCl. Proportion of PEO polymer, type of insoluble filler, proportion of tramadol HCl, amount of drug in tablet, tablet diameter and compression pressure were recognized as critical formulation and process parameters and their influence on drug release and tablet mechanical properties was evaluated. Percentages of tramadol HCl released after 30 and 240 minutes were selected for evaluation o

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M., A. Shende* R. P. Marathe. "GASTROADHESIVE SUITABILITY STUDIES FOR BACLOFEN SUSTAINED RELEASE FORMULATION." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3315–25. https://doi.org/10.5281/zenodo.997182.

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The present study is to investigate gastromucoadhesive suitability of natural polysaccharides for development of baclofen sustained release tablet formulations by increase gastric residence. Baclofen formulations were prepared by wet granulation technique and evaluated blend by FTIR, DSC for compatibility, hardness, friability, in-vitro drug release, gastric residence and mucoadhesive strength. The formulated tablets were found to have good mechanical properties and official compliance. Based on in-vitro drug release pattern and ex-vivo mucoadhesive study; the formulation B4 with drug-polymer

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Kumari, Satish, Anchal Puri, Dhruv Dev, DN Prasad, and ,. Monika. "Formulation and evaluation of sustained release matrix tablet of metoprolol succinate by using xanthan gum and carbopol." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 309–16. http://dx.doi.org/10.22270/jddt.v9i3-s.2844.

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Metoprolol succinate is a β1 selective antagonist used as an Anti-hypertensive, Anti arrhythmic, Anti Angina. The aim of present investigation was to develop matrix tablets of Metoprolol succinate using different polymers.Metoprolol succinate matrix tablet was prepared by use of xanthan gum and carbopol-934 as a polymer initially by direct compression methods. Physicochemical compatibility of the drug with polymer was confirmed by IR spectroscopy and DSC. Metoprolol succinate matrix tablets were prepared by direct compression and wet granulation method using different polymers. All the formula

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