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Bibliographies thématiques / SYNTHESIS, BIOMATERIAL, PEPTIDE, CARBOHYDRATE / Articles de revues

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Articles de revues sur le sujet « SYNTHESIS, BIOMATERIAL, PEPTIDE, CARBOHYDRATE »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Wartchow, Charles A., Peng Wang, Mark D. Bednarski, and Matthew R. Callstrom. "Carbohydrate Protease Conjugates: Stabilized Proteases for Peptide Synthesis." Journal of Organic Chemistry 60, no. 7 (1995): 2216–26. http://dx.doi.org/10.1021/jo00112a049.

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Hossain, Farzana, Shruthi Kandalai, Xiaozhuang Zhou, Nan Zhang, and Qingfei Zheng. "Chemical and Synthetic Biology Approaches for Cancer Vaccine Development." Molecules 27, no. 20 (2022): 6933. http://dx.doi.org/10.3390/molecules27206933.

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Cancer vaccines have been considered promising therapeutic strategies and are often constructed from whole cells, attenuated pathogens, carbohydrates, peptides, nucleic acids, etc. However, the use of whole organisms or pathogens can elicit unwanted immune responses arising from unforeseen reactions to the vaccine components. On the other hand, synthetic vaccines, which contain antigens that are conjugated, often with carrier proteins, can overcome these issues. Therefore, in this review we have highlighted the synthetic approaches and discussed several bioconjugation strategies for developing

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Herzner, Holger, Tanja Reipen, Michael Schultz, and Horst Kunz. "Synthesis of Glycopeptides Containing Carbohydrate and Peptide Recognition Motifs." Chemical Reviews 100, no. 12 (2000): 4495–538. http://dx.doi.org/10.1021/cr990308c.

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Badhe, Ravindra, Pradeep Kumar, Yahya Choonara, et al. "Customized Peptide Biomaterial Synthesis via an Environment-Reliant Auto-Programmer Stigmergic Approach." Materials 11, no. 4 (2018): 609. http://dx.doi.org/10.3390/ma11040609.

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Bini, Davide, Laura Russo, Chiara Battocchio, et al. "Dendron Synthesis and Carbohydrate Immobilization on a Biomaterial Surface by a Double-Click Reaction." Organic Letters 16, no. 5 (2014): 1298–301. http://dx.doi.org/10.1021/ol403476z.

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Matsubara, Teruhiko. "Potential of Peptides as Inhibitors and Mimotopes: Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries." Journal of Nucleic Acids 2012 (2012): 1–15. http://dx.doi.org/10.1155/2012/740982.

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Glycoconjugates play various roles in biological processes. In particular, oligosaccharides on the surface of animal cells are involved in virus infection and cell-cell communication. Inhibitors of carbohydrate-protein interactions are potential antiviral drugs. Several anti-influenza drugs such as oseltamivir and zanamivir are derivatives of sialic acid, which inhibits neuraminidase. However, it is very difficult to prepare a diverse range of sugar derivatives by chemical synthesis or by the isolation of natural products. In addition, the pathogenic capsular polysaccharides of bacteria are ca

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Racheva, M., O. Romero, K. K. Julich-Gruner, A. S. Ulrich, C. Wischke, and A. Lendlein. "Purity of mushroom tyrosinase as a biocatalyst for biomaterial synthesis affects the stability of therapeutic peptides." MRS Proceedings 1718 (2015): 85–90. http://dx.doi.org/10.1557/opl.2015.260.

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ABSTRACTThe formation of injectable implants in the presence of cells or solutes has previously been conceptualized to be based on the selectivity of bioorthogonal chemical reactions. As an alternative approach, hydrogel network synthesis by enzymatic reactions with a typically high inherent substrate specificity and low toxicity have been repeatedly proposed, e.g. using commercial mushroom tyrosinase (MTyr), which specifically catalyzes phenol oxidation. In this study, it should be explored whether MTyr is compatible with therapeutic peptides that may be delivered from such hydrogels in the f

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Zhong, Wei, Mariusz Skwarczynski, Yoshio Fujita, Pavla Simerska, Michael F. Good, and Istvan Toth. "Design and Synthesis of Lipopeptide - Carbohydrate Assembled Multivalent Vaccine Candidates Using Native Chemical Ligation." Australian Journal of Chemistry 62, no. 9 (2009): 993. http://dx.doi.org/10.1071/ch09065.

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Development of a synthetic vaccine against group A streptococcal infection is increasingly paramount due to the induction of autoimmunity by the main virulent factor – M protein. Peptide vaccines, however, are generally poorly immunogenic, necessitating administration with carriers and adjuvants. One of the promising approaches to deliver antigenic peptides is to assemble peptides on a suitable template which directs the attached peptides to form a well defined tertiary structure. For self-adjuvanting human vaccines, the conjugation of immunostimulatory lipids has been demonstrated as a potent

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Fernandes, Rafaella F., Giordano T. Paganoto, and Marcia L. A. Temperini. "Non-traditional intrinsic luminescence from non-conjugated polymer dots: designing a hybrid biomaterial." Polymer Chemistry 12, no. 43 (2021): 6319–28. http://dx.doi.org/10.1039/d1py01104a.

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Herein, an eco-friendly and facile synthesis of nitrogen-containing non-conjugated polymer dots (NCPD) with optimal blue emission is reported from the biopolymer β-glucan with a peptide–polysaccharide linkage (namely NH2-β-glucan).

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Herzner, Holger, Tanja Reipen, Michael Schultz, and Horst Kunz. "ChemInform Abstract: Synthesis of Glycopeptides Containing Carbohydrate and Peptide Recognition Motifs." ChemInform 32, no. 9 (2001): no. http://dx.doi.org/10.1002/chin.200109270.

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Pawar, Nitin J., Navdeep S. Sidhu, George M. Sheldrick, Dilip D. Dhavale та Ulf Diederichsen. "Molecular architecture with carbohydrate functionalized β-peptides adopting 314-helical conformation". Beilstein Journal of Organic Chemistry 10 (28 квітня 2014): 948–55. http://dx.doi.org/10.3762/bjoc.10.93.

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Carbohydrate recognition is essential in cellular interactions and biological processes. It is characterized by structural diversity, multivalency and cooperative effects. To evaluate carbohydrate interaction and recognition, the structurally defined attachment of sugar units to a rigid template is highly desired. β-Peptide helices offer conformationally stable templates for the linear presentation of sugar units in defined distances. The synthesis and β-peptide incorporation of sugar-β-amino acids are described providing the saccharide units as amino acid side chain. The respective sugar-β-am

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Scheibe, Christian, and Oliver Seitz. "PNA–sugar conjugates as tools for the spatial screening of carbohydrate–lectin interactions." Pure and Applied Chemistry 84, no. 1 (2011): 77–85. http://dx.doi.org/10.1351/pac-con-11-08-07.

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Multivalent carbohydrate–lectin interactions are essential for a multitude of biological recognition events. Much effort has been spent in the synthesis of potent multivalent scaffolds in order to mimic or inhibit biological carbohydrate–protein interactions. However, the defined spatial presentation of carbohydrates remained a challenging task. Peptide nucleic acid (PNA)- and DNA-based double helices are useful scaffolds that enable the controlled display of carbohydrate ligands in a modular approach. The hybridization of PNA-sugar conjugates with complementary DNA strands provides multivalen

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Wu, Fang-Yi, and Hsin-Chieh Lin. "Synthesis, Self-Assembly, and Cell Responses of Aromatic IKVAV Peptide Amphiphiles." Molecules 27, no. 13 (2022): 4115. http://dx.doi.org/10.3390/molecules27134115.

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Synthetic bioactive aromatic peptide amphiphiles have been recognized as key elements of emerging biomedical strategies due to their biocompatibility, design flexibility, and functionality. Inspired by natural proteins, we synthesized two supramolecular materials of phenyl-capped Ile-Lys-Val-Ala-Val (Ben-IKVAV) and perfluorophenyl-capped Ile-Lys-Val-Ala-Val (PFB-IKVAV). We employed UV-vis absorption, fluorescence, circular dichroism, and Fourier-transform infrared spectroscopy to examine the driving force in the self-assembly of the newly discovered materials. It was found that both compounds

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Opatz, Till, Christopher Kallus, Tobias Wunberg, and Horst Kunz. "Combinatorial synthesis of amino acid- and peptide-carbohydrate conjugates on solid phase." Tetrahedron 60, no. 39 (2004): 8613–26. http://dx.doi.org/10.1016/j.tet.2004.05.101.

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Güell, Imma, Rafael Ferre, Kasper Kildegaard Sørensen, et al. "Multivalent display of the antimicrobial peptides BP100 and BP143." Beilstein Journal of Organic Chemistry 8 (December 3, 2012): 2106–17. http://dx.doi.org/10.3762/bjoc.8.237.

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Carbohydrates are considered as promising templates for the display of multiple copies of antimicrobial peptides. Herein, we describe the design and synthesis of chimeric structures containing two or four copies of the antimicrobial peptides KKLFKKILKYL-NH2 (BP100) and KKLfKKILKYL-NH2 (BP143) attached to the carbohydrate template cyclodithioerythritol (cDTE) or α-D-galactopyranoside (Galp). The synthesis involved the preparation of the corresponding peptide aldehyde followed by coupling to an aminooxy-functionalized carbohydrate template. After purification, the multivalent display systems wer

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Waynant, Kristopher V., and Moubani Chakraborty. "Outside-In Strategy for Peptide-Based Methacrylate and Methacrylamide Zwitterionic Cross-Linkers." Synlett 33, no. 07 (2022): 669–73. http://dx.doi.org/10.1055/a-1754-2437.

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AbstractPolyampholyte hydrogels have shown promise as functional biomaterial platforms with resistance to nonspecific protein adsorption (nonbiofouling). Yet there are few zwitterionic cross-linkers available to complement these materials and to provide an extended charge density throughout the 3D network. The recent development of peptide-based zwitterionic cross-linkers has shown merit. Indeed, the use of functionalizable amino acids permits the synthesis of a series of peptide-based zwitterionic methacrylate and methacrylamide cross-linkers. Methacrylate additions prior to peptide coupling

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Afanasyeva, Ksenia A., Anastasia М. Gileva, Elena A. Markvicheva, Ulyana A. Budanova та Yurii L. Sebyakin. "GLYCOLIPOTRIPEPTIDE (N-LACTITOL-Gly)2-LysС16 AND ITS FLUORESCENTLY LABELED ANALOGUE FOR VISUALIZATION OF VECTOR SYSTEMS FOR BIOLOGICALLY ACTIVE SUBSTANCES DELIVERY TO TARGET CELLS". Lomonosov chemistry journal 64, № 5, 2023 (2023): 478–89. http://dx.doi.org/10.55959/msu0579-9384-2-2023-64-5-478-489.

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The work is devoted to the preparation of a carbohydrate derivative of lipotripeptide (N-lactitol-Gly)2-LysC16 of irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent label in a hydrophobic fragment. The developed synthesis scheme includes universal approaches of peptide chemistry, as well as the stages of formation of an acyclic carbohydrate based on lactose in the hydrophilic domain of amphiphile. The compounds are designed to create compositions of vector BAS delivery

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Depezay, J. C. "ChemInform Abstract: Synthesis of Enantiopure Azasugars from D-mannitol: Carbohydrate and Peptide Mimics." ChemInform 30, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.199922260.

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Jiang, Rui-Jian, Bo Yang, Dong Yi та ін. "Synthesis and characterization of a series of novel amino β-cyclodextrin-conjugated poly(ε-lysine) derivatives". Journal of Polymer Engineering 34, № 2 (2014): 133–39. http://dx.doi.org/10.1515/polyeng-2013-0194.

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Abstract Soluble poly(ε-lysine)s bearing β-cyclodextrin (β-CD) moieties were prepared by three amino β-CD derivatives and N-succinylated poly(ε-lysine), in which the poly(ε-lysine) and amino β-CD derivatives were bonded covalently to the end carboxyl groups of succinic acid by peptide bonds. 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI) and N-hydroxysuccinimide (NHS) were chosen to assist the reaction. The three poly(ε-lysine) derivatives were characterized by 1H nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FT-IR). The synthesis process is simple, f

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Duggan, Peter J., and Daniel A. Offermann. "The Preparation of Solid-Supported Peptide Boronic Acids Derived from 4-Borono-L-phenylalanine and their Affinity for Alizarin." Australian Journal of Chemistry 60, no. 11 (2007): 829. http://dx.doi.org/10.1071/ch07143.

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A library of solid-supported pentapeptide diboronic acids, a ‘lysine series’ and an ‘arginine series’, has been efficiently prepared using N-Fmoc-4-pinacolatoborono-l-phenylalanine and standard solid phase peptide synthesis methods. A technique for measuring the affinity of the chromophoric diol, alizarin, to the solid-supported peptide boronic acids has been developed. Considerable variation in alizarin binding strengths, both within and between arginine and lysine series was observed, with association constants in the range 200–1100 M–1 being recorded. The selective binding characteristics o

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Leighton, B., and E. A. Foot. "The role of the sensory peptide calcitonin-gene-related peptide(s) in skeletal muscle carbohydrate metabolism: effects of capsaicin and resiniferatoxin." Biochemical Journal 307, no. 3 (1995): 707–12. http://dx.doi.org/10.1042/bj3070707.

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1. The content of calcitonin-gene-related-peptide-like immunoreactivity (CGRP-LI) in various rat muscles was measured. Starvation for 24 h did not affect the content of CGRP-LI in these muscles, except for a decreased level in the starved-rat diaphragm. Higher contents of CGRP-LI were observed in well-vascularized muscles. 2. Capsaicin (at 1, 10 and 100 microM) inhibited insulin-stimulated rates of glycogen synthesis in isolated stripped incubated soleus muscle preparations by a mechanism independent of catecholamine release, since the effects of capsaicin were not altered by the beta-adrenore

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Kihlberg, Jan, and Mikael Elofsson. "Solid-Phase Synthesis of Glycopeptides: Immunological Studies with T Cell Stimulating Glycopeptides." Current Medicinal Chemistry 4, no. 2 (1997): 85–116. http://dx.doi.org/10.2174/0929867304666220309204820.

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Stepwise solid-phase synthesis using glycosylated amino acids as puilding blocks has been shown to be the most general and efficient approach for preparation of glycopeptides. The a-amino group of the glycosylated amino acids should be protected with the fluoren-9-ylmethoxy carbonyl (Fmoc) group whereas acetyl groups, or acid labile protective groups, are suitable for the carbohydrate hydroxyl groups. Due to the recent rapid development of Fmoc solid-phase glycopeptide synthesis glycopeptides are increasingly being made available for investigations in biological sciences, such as studies of t

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Sršan, Laura, and Thomas Ziegler. "Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations." Beilstein Journal of Organic Chemistry 16 (April 30, 2020): 888–94. http://dx.doi.org/10.3762/bjoc.16.80.

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For investigations on the biological functions of oligosaccharides and peptidomimetics, new asparagine-based mono- and disaccharides containing glycopeptides were prepared in solution. The applicability of two common peptide coupling reagents, using an orthogonal Fmoc/t-Bu strategy along with acetyl protecting groups for the carbohydrate moiety, was studied. Thus, the prepared libraries of glycopeptides were designed as model systems of cell surfaces for future investigations by combined preparative mass spectroscopy and scanning tunneling microscopy (STM) using soft-landing electrospray beam

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Timmer, Mattie S. M., Steven H. L. Verhelst, Gijsbert M. Grotenbreg, Mark Overhand, and Herman S. Overkleeft. "Carbohydrates as versatile platforms in the construction of small compound libraries." Pure and Applied Chemistry 77, no. 7 (2005): 1173–81. http://dx.doi.org/10.1351/pac200577071173.

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This paper presents our recent results concerning the use of carbohydrates as cheap, chiral, and enantiopure starting materials in the construction of a variety of densely functionalized molecules. The compatibility of ring-closing metathesis with standard carbohydrate chemistry is demonstrated in the synthesis of new stereoisomers of deoxystreptamine and neamine–important building blocks for the generation of synthetic aminoglycosides with potential antibacterial activity. Ring-closing metathesis is also a key step in the rapid synthesis of new indolizidines and quinolizidines, and in a new s

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Forget, D., D. Boturyn, O. Renaudet, E. Defrancq, and P. Dumy. "Highly Efficient Synthesis of Peptide- and Carbohydrate-Oligonucleotide Conjugates Using Chemoselective Oxime and Thiazolidine Formation." Nucleosides, Nucleotides and Nucleic Acids 22, no. 5-8 (2003): 1427–29. http://dx.doi.org/10.1081/ncn-120023001.

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Chu, Hanyu, Lijie Zhou, Yanzhen Mao, et al. "Anti-Inflammatory Function Analysis of Lacticaseibacillus rhamnosus CP-1 Strain Based on Whole-Genome Sequencing." BioTech 14, no. 2 (2025): 47. https://doi.org/10.3390/biotech14020047.

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Lacticaseibacillus rhamnosus (L. rhamnosus) is a safe probiotic with no side effects, providing benefits such as gut microbiota regulation and immune enhancement, making it highly valuable with strong potential. However, strains from different sources have unique traits, and whole-genome sequencing (WGS) helps analyse these differences. In this study, we used WGS to examine L. rhamnosus strains from mice with fish oil-treated smoking-induced pneumonia to better understand their biological functions and explore possible anti-inflammatory mechanisms. Methods: We isolated a strain, Lacticaseibaci

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Johnson, Margaret A., Adewale A. Eniade, and B. Mario Pinto. "Rational design and synthesis of peptide ligands for an anti-Carbohydrate antibody and Their immunochemical characterization." Bioorganic & Medicinal Chemistry 11, no. 5 (2003): 781–88. http://dx.doi.org/10.1016/s0968-0896(02)00449-2.

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Rivera, Daniel G., Karell Pérez-Labrada, Liudmila Lambert, Simon Dörner, Bernhard Westermann, and Ludger A. Wessjohann. "Carbohydrate–steroid conjugation by Ugi reaction: one-pot synthesis of triple sugar/pseudo-peptide/spirostane hybrids." Carbohydrate Research 359 (October 2012): 102–10. http://dx.doi.org/10.1016/j.carres.2012.05.003.

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George, Shaji K., Björn Holm, Celso A. Reis, Tilo Schwientek, Henrik Clausen, and Jan Kihlberg. "Chemoenzymatic synthesis of derivatives of a T-cell-stimulating peptide which carry tumor-associated carbohydrate antigens." Journal of the Chemical Society, Perkin Transactions 1, no. 8 (2001): 880–85. http://dx.doi.org/10.1039/b009567m.

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Dondoni, Alessandro. "Selected Research Topics of the Dondoni Group over the Last Two Decades (2000–2020)." Synlett 31, no. 14 (2020): 1361–71. http://dx.doi.org/10.1055/s-0040-1707107.

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From a selection of research topics carried out in our laboratory during the last twenty years it becomes apparent that our main target was the discovery of new or improved synthetic methods together with new properties. Our efforts were made with the aim of being of some utility to other fields of research, with particular emphasis to glycobiology and heterocyle-based bioorganic chemistry. We performed new chemistry mainly in the field of carbohydrate manipulations taking as a primary rule the simplicity and efficiency manners. Toward this end, modern synthetic tools and approaches were emplo

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Lin, Feng, Mohammed Akhter Hossain, Stephanie Post, et al. "Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2)." Australian Journal of Chemistry 70, no. 2 (2017): 208. http://dx.doi.org/10.1071/ch16626.

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In the fruit fly Drosophila melanogaster, there are eight insulin-like peptides (DILPs) with DILPs 1–7 interacting with a sole insulin-like receptor tyrosine kinase (DInR) while DILP8 interacts with a single G protein-coupled receptor (GPCR), Lgr3. Loss-of-function dilp mutation studies show that the neuropeptide DILP2 has a key role in carbohydrate and lipid metabolism as well as longevity and reproduction. A better understanding of the processes whereby DILP2 mediates its specific actions is required. Consequently we undertook to prepare DILP2 as part of a larger, detailed structure–function

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Mantsou, Aglaia, Eleni Papachristou, Panagiotis Keramidas та ін. "Fabrication of a Smart Fibrous Biomaterial That Harbors an Active TGF-β1 Peptide: A Promising Approach for Cartilage Regeneration". Biomedicines 11, № 7 (2023): 1890. http://dx.doi.org/10.3390/biomedicines11071890.

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The regeneration of articular cartilage remains a serious problem in various pathological conditions such as osteoarthritis, due to the tissue’s low self-healing capacity. The latest therapeutic approaches focus on the construction of biomaterials that induce cartilage repair. This research describes the design, synthesis, and investigation of a safe, “smart”, fibrous scaffold containing a genetically incorporated active peptide for chondrogenic induction. While possessing specific sequences and the respective mechanical properties from natural fibrous proteins, the fibers also incorporate a T

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Denning, Gerene M., Kevin G. Leidal, Valerie A. Holst, et al. "Calreticulin Biosynthesis and Processing in Human Myeloid Cells: Demonstration of Signal Peptide Cleavage and N-Glycosylation." Blood 90, no. 1 (1997): 372–81. http://dx.doi.org/10.1182/blood.v90.1.372.

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Abstract Calreticulin is a soluble endoplasmic reticulum protein comprising the major storage reservoir for inositol trisphosphate-releasable calcium. Although its highly conserved primary structure and a wide range of functions have been well described, less attention has been paid to its biosynthesis, particularly in human tissues. We report analyses of synthesis, proteolytic processing and glycosylation of human calreticulin. In both HL-60 and PLB-985 myeloid cell lines calreticulin was immunoprecipitated as a single 60-kD species without evidence of precursor forms. However, in vitro cell-

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Denning, Gerene M., Kevin G. Leidal, Valerie A. Holst, et al. "Calreticulin Biosynthesis and Processing in Human Myeloid Cells: Demonstration of Signal Peptide Cleavage and N-Glycosylation." Blood 90, no. 1 (1997): 372–81. http://dx.doi.org/10.1182/blood.v90.1.372.372_372_381.

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Calreticulin is a soluble endoplasmic reticulum protein comprising the major storage reservoir for inositol trisphosphate-releasable calcium. Although its highly conserved primary structure and a wide range of functions have been well described, less attention has been paid to its biosynthesis, particularly in human tissues. We report analyses of synthesis, proteolytic processing and glycosylation of human calreticulin. In both HL-60 and PLB-985 myeloid cell lines calreticulin was immunoprecipitated as a single 60-kD species without evidence of precursor forms. However, in vitro cell-free synt

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Hahm, Heung Sik, Mark K. Schlegel, Mattan Hurevich, et al. "Automated glycan assembly using the Glyconeer 2.1 synthesizer." Proceedings of the National Academy of Sciences 114, no. 17 (2017): E3385—E3389. http://dx.doi.org/10.1073/pnas.1700141114.

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Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis has fundamentally altered biological research and medical practice. Similarly, the procurement of defined glycans is key to establishing structure–activity relationships and thereby progress in the glycosciences. Here, we describe the rapid assembly of oligosaccharides using the commercially available Glyconeer 2.1 automated glycan synthesizer, monosaccharide building blocks, and a linker-functionalized polystyrene solid support. Purification and quality-control protocols for the oligosaccharide products ha

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Tian, Xizhe, Jaeyoung Pai, Kyung-Hwa Baek, Sung-Kyun Ko, and Injae Shin. "Fluorophore-labeled, Peptide-based Glycoclusters: Synthesis, Binding Properties for Lectins, and Detection of Carbohydrate-Binding Proteins in Cells." Chemistry - An Asian Journal 6, no. 8 (2011): 2107–13. http://dx.doi.org/10.1002/asia.201100319.

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Serebryakova, V. A., O. E. Vaizova, E. L. Golovina, and V. V. Kochubey. "Galectins: a potential pharmacological target." Bulletin of Siberian Medicine 23, no. 3 (2024): 155–62. http://dx.doi.org/10.20538/1682-0363-2024-3-155-162.

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Aim. To consider the use of galectin-1 and galectin-3 inhibitors as potential pharmacological targets in antitumor and antifibrotic therapy.The lecture includes the analysis of experimental research and review articles presented in the PubMed database. A brief description of the structure of galectins is given. Their generally accepted classification and features of the structure of the carbohydrate recognition domain in galectin-1 and galectin-3 are presented. The main part of the lecture describes the results of research on the development of carbohydrate-based (β-galactoside derivatives or

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Ross, Günther, та Ivar Ugi. "Stereoselective syntheses of α-amino acid and peptide derivatives by the U-4CR of 5-desoxy-5-thio-D-xylopyranosylamine". Canadian Journal of Chemistry 79, № 12 (2001): 1934–39. http://dx.doi.org/10.1139/v01-186.

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Since 1961, the synthesis of α-amino acids derivatives by the four-component reaction of isocyanides (U-4CR) as a one-pot reaction has been developed. Only recently it was found that a variety of these α-amino acids compounds can be formed stereoselectively by the U-4CR using 1-amino-5-deoxy-5-thio-2,3,4-tri-O-isobutanoyl-β-D-xylopyranose as the amine component. The stereoselectivity inducing auxiliary 5-desoxy-5-thio-D-xylopyranosyl group of the so-formed products can be replaced selectively by hydrogen.Key words: stereoselective U-4CR, chiral amine component, amino carbohydrate, α-amino acid

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Nikolaeva, Tatiana N., Tatiana N. Kozhevnikova, Elena I. Vostrova, et al. "Comparative assessment of the intestinal microbiota, lipid metabolism and morphological changes of the liver in experimental models of metabolic syndrome." Experimental and Clinical Gastroenterology, no. 7 (October 7, 2022): 158–64. http://dx.doi.org/10.31146/1682-8658-ecg-203-7-158-164.

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Metabolic syndrome (MS) is a widespread polyethiological clustering characterized by metabolic, hormonal disorders and clinical manifestations that significantly increase the risk of developing cardiovascular diseases, atherosclerosis, type II diabetes and other pathological conditions. An important role in the development of MS is assigned to the intestinal microbiota. To develop new therapeutic agents for correction of MS manifestations, it is necessary to develop adequate experimental models. In this paper, comparative studies were conducted to assess the parameters of lipid metabolism, the

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Kumar, K. Ganesh, Angela C. Poole, Barbara York, Julia Volaufova, Aamir Zuberi, and Brenda K. Smith Richards. "Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: congenic strain confirmation and candidate gene analyses (Glo1, Glp1r)." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 292, no. 1 (2007): R207—R216. http://dx.doi.org/10.1152/ajpregu.00491.2006.

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Quantitative trait loci (QTL) for carbohydrate ( Mnic1) and total energy ( Kcal2) intake on proximal mouse chromosome 17 were identified previously from a C57BL/6J (B6) X CAST/Ei (CAST) intercross. Here we report that a new congenic strain developed in our laboratory has confirmed this complex locus by recapitulating the original linked phenotypes: B6.CAST-17 homozygous congenic mice consumed more carbohydrate (27%) and total energy (17%) compared with littermate wild-type mice. Positional gene candidates with relevance to carbohydrate metabolism, glyoxalase I ( Glo1) and glucagon-like peptide

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Raposo, G., H. M. van Santen, R. Leijendekker, H. J. Geuze, and H. L. Ploegh. "Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment." Journal of Cell Biology 131, no. 6 (1995): 1403–19. http://dx.doi.org/10.1083/jcb.131.6.1403.

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Misfolded membrane proteins are rapidly degraded, often shortly after their synthesis and insertion in the endoplasmic reticulum (ER), but the exact location and mechanisms of breakdown remain unclear. We have exploited the requirement of MHC class I molecules for peptide to achieve their correct conformation: peptide can be withheld by introducing a null mutation for the MHC-encoded peptide transporter, TAP. By withholding TAP-dependent peptides, the vast majority of newly synthesized class I molecules fails to leave the endoplasmic reticulum and is degraded. We used mice transgenic for HLA-B

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Cudic, Mare, Ramya Ayyalasomayajula, Ivet Boneva, Donella M. Beckwith, Sabine André, and Herbert Kaltner. "Abstract A012: Targeting macrophage galactose binding lectin -tumor associated MUC1 immune axis in cancer." Cancer Immunology Research 13, no. 2_Supplement (2025): A012. https://doi.org/10.1158/2326-6074.io2025-a012.

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Abstract Carbohydrate-binding proteins, lectins, are the main binding partners of tumor-associated carbohydrate antigens (TACAs) on the cell surface. Interactions between the tumor-associated carbohydrate antigens of Mucin 1 (TA MUC1) and the carbohydrate-binding proteins, lectins, often lead to the creation of a pro-tumor microenvironment favoring tumor initiation, progression, metastasis, and immune evasion. Macrophage galactose binding lectin (MGL) is a C-type lectin receptor found on antigen-presenting cells that facilitates the uptake of carbohydrate antigens for antigen presentation, mod

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Utkina, V. A., and L. M. Stepchenko. "The effect of humic substances on carbohydrate metabolism in alloxan-induced diabetes mellitus in rats." Theoretical and Applied Veterinary Medicine 9, no. 2 (2021): 96–97. http://dx.doi.org/10.32819/2021.92015.

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The article presents study results of the effect of humic nature biologically active additive «Humilid» on carbohydrate metabolism, namely on glucose, insulin and C-peptide in alloxan-induced diabetes mellitus in rats. The purpose of the experiment was to investigate how “Humilid” affects carbohydrate metabolism in rats; to study and analyze the effect of the humic nature biologically active substance «Humilid» on metabolic processes. In the work we used biochemical methods for studying the blood of experimental rats. Adult male white rats were taken for the experiment, from which four groups

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Gyuricza, Barbara, Ágnes Szűcs, Judit P. Szabó, et al. "The Synthesis and Preclinical Investigation of Lactosamine-Based Radiopharmaceuticals for the Detection of Galectin-3-Expressing Melanoma Cells." Pharmaceutics 14, no. 11 (2022): 2504. http://dx.doi.org/10.3390/pharmaceutics14112504.

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Given that galectin-3 (Gal-3) is a β-galactoside-binding lectin promoting tumor growth and metastatis, it could be a valuable target for the treatment of Gal-3-expressing neoplasms. An aromatic group introduced to the C-3′ position of lactosamine increased its affinity for Gal-3. Herein, we aimed at developing a radiopharmaceutical for the detection of Gal-3 positive malignancies. To enhance tumor specificity, a heterodimeric radiotracer capable of binding to both Gal-3 and αvβ3 integrin was also synthetized. Arginine-glycine-asparagine (RGD) peptide is the ligand of angiogenesis- and metastas

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Wang, Yun, Kevin Seburn, Lawrence Bechtel, et al. "Defective carbohydrate metabolism in mice homozygous for the tubby mutation." Physiological Genomics 27, no. 2 (2006): 131–40. http://dx.doi.org/10.1152/physiolgenomics.00239.2005.

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Tub is a member of a small gene family, the tubby-like proteins (TULPs), with predominant expression in neurons. Mice carrying a mutation in Tub develop retinal and cochlear degeneration as well as late-onset obesity with insulin resistance. During behavioral and metabolic testing, we found that homozygous C57BL/6J- Tub tub mice have a lower respiratory quotient than C57BL/6J controls before the onset of obesity, indicating that tubby homozygotes fail to activate carbohydrate metabolism and instead rely on fat metabolism for energy needs. In concordance with this, tubby mice show higher excret

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Zeuner, Birgitte, David Teze, Jan Muschiol, and Anne S. Meyer. "Synthesis of Human Milk Oligosaccharides: Protein Engineering Strategies for Improved Enzymatic Transglycosylation." Molecules 24, no. 11 (2019): 2033. http://dx.doi.org/10.3390/molecules24112033.

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Human milk oligosaccharides (HMOs) signify a unique group of oligosaccharides in breast milk, which is of major importance for infant health and development. The functional benefits of HMOs create an enormous impetus for biosynthetic production of HMOs for use as additives in infant formula and other products. HMO molecules can be synthesized chemically, via fermentation, and by enzymatic synthesis. This treatise discusses these different techniques, with particular focus on harnessing enzymes for controlled enzymatic synthesis of HMO molecules. In order to foster precise and high-yield enzyma

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Marcos, Nuno T., Andrea Cruz, Filipe Silva, et al. "Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I Expression in Gastric Carcinoma Cell Lines." Journal of Histochemistry & Cytochemistry 51, no. 6 (2003): 761–71. http://dx.doi.org/10.1177/002215540305100607.

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Mucin O-glycosylation in cancer is characterized by aberrant expression of immature carbohydrate structures leading to exposure of simple mucin-type carbohydrate antigens and peptide epitopes. Glycosyltransferases controlling the initial steps of mucin O-glycosylation are responsible for the altered glycosylation observed in cancer. We studied the expression in gastric cell lines of six UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc-T1, T2, T3, T4, T6, T11) that catalyze the initial key step in the regulation of mucin O-glycosylation, the transfer of GalNAc from UDP-GalNAc t

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Montero, Ana, Enrique Mann, and Bernardo Herradón. "The Overman rearrangement in carbohydrate chemistry: stereoselective synthesis of functionalized 3-amino-3,6-dihydro-2H-pyrans and incorporation in peptide derivatives." Tetrahedron Letters 46, no. 3 (2005): 401–5. http://dx.doi.org/10.1016/j.tetlet.2004.11.109.

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Yang, Haiyan, Yongkang Duan, Zhiwen Wei, et al. "Integrated Physiological and Metabolomic Analyses Reveal the Differences in the Fruit Quality of the Blueberry Cultivated in Three Soilless Substrates." Foods 11, no. 24 (2022): 3965. http://dx.doi.org/10.3390/foods11243965.

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With improving living standards, traditional blueberry planting modes cannot meet commercial demands, and blueberry cultivation with soilless substrate has become a popular solution in the blueberry industry. In this study, different soilless substrate treatments were found to markedly influence fruit appearance and intrinsic quality. The fruit in the 50:50 peat/pine bark (v/v) (FPB) treatment group had the maximum single fruit weight, largest vertical diameter, and brightest color, as well as the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH) value, solid-acid ratio and anthocyanin content. The

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Funtan, Sebastian, Anne Funtan, Reinhard Paschke, and Wolfgang H. Binder. "Biomimetic Elastin-Like Polypeptides as Materials for the Activation of Mechanophoric Catalysts." Organic Materials 02, no. 02 (2020): 116–28. http://dx.doi.org/10.1055/s-0040-1702149.

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Elastin-like polypeptides (ELPs) are well known for their elastic and thermoresponsive behaviors. Their elasticity originates from the formation of a β-spiral which is the consequence of stacking type-II β-turns, formed from individual VPGVG pentapeptide units. Here, the synthesis of ELPs of varying chain lengths [VPGVG, (VPGVG)2, and (VPGVG)4] and their coupling to a mechanoresponsive catalyst are reported. The attached ELP chains can act as “molecular springs,” allowing for an efficient uptake and transmission of an applied force to the mechanophoric bond. This leads to stress-induced activa

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