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Livres sur le sujet « Target binding »

Auteur : Grafiati

Publié le 11 mars 2023

Mis à jour le 31 juillet 2025

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1

Symposium on RNA Biology (2nd 1997 North Carolina Biotechnology Center). Symposium on RNA Biology: RNA tool and target : held at North Carolina Biotechnology Center, Research Triangle Park, North Carolina, USA, October 17-19, 1997. Oxford University Press, 1997.

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2

Snoeck, Eric. Mechanism-based pharmacokinetic-pharmacodynamic modelling of specific target site binding to red blood cells: Application to the development of draflazine. University of Leiden, 1998.

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3

Podjarny, Alberto, Annick P. Dejaegere, and Bruno Kieffer, eds. Biophysical Approaches Determining Ligand Binding to Biomolecular Targets. Royal Society of Chemistry, 2011. http://dx.doi.org/10.1039/9781849732666.

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4

Ponte-Sucre, Alicia. ABC transporters in microorganisms: Research, innovation and value as targets against drug resistance. Caister Academic, 2009.

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5

Chandrudu, M. V. Rama. Bench marking of APRLP processes: Binding the programs with processes : redefining targets. WASSAN, 2006.

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6

Lans, Martine C. Thyroid hormone binding proteins as novel targets for hydroxylated polyhalogenated aromatic hydrocarbons (PHAHs): Possible implications for toxicity. [s.n.], 1995.

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7

Dufau, Maria. Hormone Binding and Target Cell Activation in the Testis. Springer, 2013.

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8

Dufau, Maria. Hormone Binding and Target Cell Activation in the Testis. Springer, 2012.

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9

Matulis, Daumantas. Carbonic Anhydrase as Drug Target: Thermodynamics and Structure of Inhibitor Binding. Springer, 2019.

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10

Ming, Liang. Identification of DNA-binding domains and target genes of the Hindsight zinc-finger protein. 2006.

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11

Baauw, Sergio. The Acquisition of Binding and Coreference. Edited by Jeffrey L. Lidz, William Snyder, and Joe Pater. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199601264.013.22.

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In this chapter the acquisition of pronouns and reflexives is discussed. It reviews several accounts of the so-called Delay of Principle B Effect, the absence of this effect in some languages, and the structural factors that influence its appearance in child language. It also discusses children’s alledged target-like performance on reflexives in several languages with different type of reflexives. The chapter concludes that provided a balanced experimental design is used, the experimental results point at early mastery of Principle A and B, and that children’s difficulties with the interpretat

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12

LaPorte, Jacob Ryan. Identification of GAPDH as a protein target of the saframycin antiproliferative agents: Synthetic studies of maduropeptin chromophore. 2007.

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13

Luginbühl, Béatrice Barbara Cécile. Affinity maturation towards low picomolar anti-prion protein antibodies: Directed evolution of binding to conformationally unstable target proteins. 2006.

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14

Nurmikko, Turo J. Identification of the target of gabapentinoid action in neuropathic pain. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0070.

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The landmark paper discussed in this chapter is ‘Identification of the α‎2-δ‎-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin’, published by Field et al. in 2006. In this seminal paper, Field et al. demonstrated that the anti-allodynic effect of pregabalin is related to its binding to the α‎2δ‎-1 subunit of the voltage-gated calcium channel. In transgenic mice lacking this subunit, pregabalin had no effect on allodynia induced by sciatic nerve ligation, whereas, in wild-type mice, there was a substantial anti-allodyni

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15

Biophysical Approaches Determining Ligand Binding to Biomolecular Targets 24: Biomolecular Science Series Biophysical Approaches Determining Ligand Binding to Biomolecular Targets. Royal Society of Chemistry, The, 2011.

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16

Osbert Cotta, Menino, and Jason Roberts. Pharmacokinetic and pharmacodynamic principles of antimicrobials. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198758792.003.0009.

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The continual threat of antimicrobial resistance means that optimizing current antimicrobial therapy is of paramount importance. Antimicrobial pharmacokinetics and pharmacodynamics (PK/PD) play a central role in developing dosing regimens that target maximal clinical outcomes and microbiological eradication. This chapter describes the three main PK/PD indices into which current antimicrobials are categorized. Elements of PK that require due consideration when optimizing antimicrobial therapy, including volume of distribution, antimicrobial clearance, and protein binding, are also discussed. Fi

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Hypothesis That Proposes That in ALDH18A1 Spastic Paraplegia, the Failure to Produce Specific Proline Residues Required for the Binding of SEC23IP As Part of the COP2 Transport Process Could Be Causative of Symptoms and May Be a Viable Treatment Target. Lulu Press, Inc., 2017.

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18

Wolfe, Jeremy M. Approaches to Visual Search. Edited by Anna C. (Kia) Nobre and Sabine Kastner. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199675111.013.002.

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In her original Feature Integration Theory, Anne Treisman proposed that we process a limited set of basic preattentive, visual features in parallel across the visual field. Binding those features together into coherent, recognizable objects requires selective attention of item after item. In Treisman’s original conception, searches were divided into parallel feature searches and other serial self-terminating searches. Wolfe’s Guided Search model added the idea that the deployment of attention could be guided by preattentive information. In this view, the efficiency of search is related to the

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Biophysical Approaches Determining Ligand Binding to Biomolecular Targets: Detection, Measurement and Modelling. Royal Society of Chemistry, The, 2011.

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20

Cui, Zhao, Neil Turner, and Ming-hui Zhao. Alport post-transplant antiglomerular basement membrane disease. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0075.

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Alport antiglomerular basement membrane (anti-GBM) disease is a rare example of disease caused by allo-sensitization after renal transplantation, first described in 1992. Because the recipient lacks a specific glomerular basement membrane (GBM) protein, they can become sensitized to the normal molecule present in the GBM of the donor kidney. The disease is restricted to the allograft. Interestingly severe disease arises from this only arises rarely, certainly less than 1 in 20, probably closer to 1 in 50. It characteristically causes late graft loss in a first transplant with accelerated tempo

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Wiklund, Olov, and Jan Borén. Pathogenesis of atherosclerosis: lipid metabolism. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0011.

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Lipids are carried in plasma as microparticles, lipoproteins, composed of a core of hydrophobic lipids and a surface of amphipathic lipids. In addition, the particles carry proteins (i.e. apolipoproteins). The proteins have key functions in the metabolism as receptor ligands, enzymes or activators. Lipoproteins are classified based on density into: chylomicrons, VLDL, IDL, LDL, and HDL. Retention of apoB-containing lipoproteins (LDL, IDL, and VLDL) in the arterial intima is the initiating event in the development of atherosclerosis. Retention is mediated by binding of apoB to structural proteo

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Ferran, Christiane. Multiple Therapeutic Targets of A20. Springer London, Limited, 2014.

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Ferran, Christiane. The Multiple Therapeutic Targets of A20. Springer, 2014.

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Ferran, Christiane. The Multiple Therapeutic Targets of A20. Springer, 2016.

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25

Jörres, Achim, Dietrich Hasper, and Michael Oppert. Non-dialytic management of the patient with acute kidney injury. Edited by Norbert Lameire. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0228.

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The main focus in the non-dialytic management of patients with acute kidney injury (AKI) is the prevention and treatment of complications.Nutritional support is an important aspect as many patients tend to be hypercatabolic, thus requiring adequate caloric intake, yet without administration of excessive fluid volumes. Inadequate nutrition in AKI may lead to enhanced production of urea nitrogen and azotaemia. However, hyperglycaemia is a frequent complication in these patients, often requiring continuous insulin therapy to achieve the recommended blood glucose target range of 110–150 mg/dL (6.1

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Lidz, Jeffrey L., William Snyder, and Joe Pater, eds. The Oxford Handbook of Developmental Linguistics. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199601264.001.0001.

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This handbook provides a thorough and systematic investigation of the question of how we come to know a language. Researchers from all over the world explore the leading research questions within developmental linguistics, which include: What does the newborn child bring to the task of language acquisition? What information must the child extract from her linguistic input? And how does biological maturation interact with the child’s developing linguistic abilities? In the main body of the handbook, each chapter addresses a single area of grammatical knowledge, such as syllable structure, negat

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27

Guthrie, Graeme. Fighting back. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780190641184.003.0013.

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A board of directors that attempts to defeat a hostile takeover attempt will try to raise the cost and lower the value of the shares the raider needs to complete the takeover. This can be achieved using binding contractual arrangements with the target’s customers, suppliers, and employees, that lower the value of the firm if it is acquired, but do not directly affect it otherwise. Boards resisting a hostile takeover will also issue carefully designed securities to the target’s bondholders and shareholders that have a similar effect. Ultimately, a target’s board can reconfigure the firm’s capit

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Ovodenko, Alexander. Industrial and Artisanal Producers and the Hybrid Governance of Mercury Pollution. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190677725.003.0005.

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The chapter studies the regulation of different industries under the same treaty, although it assesses the impacts of upstream producer-level differences on regime design. It focuses on the new mercury treaty negotiated in January 2013 and evaluates the markets theory on a micro-foundational level with 85 original survey responses from government negotiators and nongovernment participants in the final meeting of the treaty negotiations, as well as 13 in-depth interviews with negotiation participants. The findings show that negotiators of the mercury treaty recognized the need for nonbinding an

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Krahl, Daniel. The Paris Agreement—China’s Kind of (International) Order? Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198828945.003.0014.

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The Paris Agreement has turned traditional approaches to global governance upside down, using a bottom-up approach that made it possible for emerging powers like China to agree to binding emissions targets to contain climate change. It thus marks a further step away from the old order centered on Western power, and at the same time it fits well into Chinese attempts to create a post-American order that rests on great power diplomacy within a multilateral framework of cooperation that privileges developing countries. The Paris Agreement allows China to leverage the internal fight against pollut

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Reinisch, August. Sources of International Organizations’ Law. Edited by Samantha Besson and Jean d’Aspremont. Oxford University Press, 2018. http://dx.doi.org/10.1093/law/9780198745365.003.0047.

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This chapter notes that for a considerable period, international organizations scholarship was preoccupied with establishing international organizations as actors enjoying their own international legal personality. With the increase and diversification of tasks fulfilled by such organizations, the question has come to the fore as to what extent these subjects of international law may become responsible for their actions. This debate has overshadowed the underlying and more fundamental question of what kinds of obligations can be identified as binding upon international organizations. According

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Brunner, Ronald D., and Amanda H. Lynch. Adaptive Governance. Oxford University Press, 2017. http://dx.doi.org/10.1093/acrefore/9780190228620.013.601.

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Adaptive governance is defined by a focus on decentralized decision-making structures and procedurally rational policy, supported by intensive natural and social science. Decentralized decision-making structures allow a large, complex problem like global climate change to be factored into many smaller problems, each more tractable for policy and scientific purposes. Many smaller problems can be addressed separately and concurrently by smaller communities. Procedurally rational policy in each community is an adaptation to profound uncertainties, inherent in complex systems and cognitive constra

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