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Thèses sur le sujet « Thioredoxin »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 25 mai 2024

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1

Paunescu, Karina. "DNA-Stabilität und Thioredoxin-Thioredoxin-Reduktase im Zellkern." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969680333.

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2

Osborne, Leisa Jane. "Characterisation of Thioredoxin Dimers: A Biochemical Study." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/365531.

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In addition to the conserved active site cysteines that are responsible for the classical redox activity of thioredoxins (Trx’s), vertebrate Trx’s contain an additional three conserved cysteines at position 62, 69 and 73. These structural cysteines are known to be subjected to a variety of post translational modifications including dimerisation that are believed to contribute to the regulation and diversity of function of vertebrate Trx’s. Reports of the formation of “disulphide linked dimers” have been a long standing observation since the earliest studies on vertebrate Trx’s, however detaile

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3

Missirlis, Fanis. "Functional characterization of novel thioredoxin reductase and thioredoxin peroxidase in Drosophila." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2002. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ65830.pdf.

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4

Shah, Fenil. "Thioredoxin and its Target Proteins: Thioredoxin Expression under Different Oxygen Conditions." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/367670.

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Thioredoxin is an antioxidant protein that performs multiple functions in the intracellular and extracellular environment of cells. Thioredoxin is highly expressed in cancer cells, especially more metastatic and aggressive cancers. Previous studies have demonstrated a functional role for thioredoxin in cancer cell invasion, however little information is currently available regarding the role of thioredoxin in the invasive process. In order to perform these and other functions, thioredoxin interacts with several different protein partners. The primary aim of this project was to identify previou

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5

Gregory, Mary Sarah-Jane, and n/a. "Thioredoxin and Oxidative Stress." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040301.082639.

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The experiments described in this thesis involve the expression and characterisation of recombinant truncated thioredoxin (tTrx) and the potential involvement that thioredoxin (Trx) has in the cellular responses to oxidative stress. Truncated Trx (80 amino acids) was expressed from a plasmid containing the ORF for tTrx that had been introduced into E.coli BL-21(DE3) cells. The protein was initially extracted using a combination of high concentrations of urea, high pH levels, and multiple sonification steps to remove the tTrx from inclusion bodies formed during expression. This procedure pro

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6

Gregory, Mary Sarah-Jane. "Thioredoxin and Oxidative Stress." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/367183.

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The experiments described in this thesis involve the expression and characterisation of recombinant truncated thioredoxin (tTrx) and the potential involvement that thioredoxin (Trx) has in the cellular responses to oxidative stress. Truncated Trx (80 amino acids) was expressed from a plasmid containing the ORF for tTrx that had been introduced into E.coli BL-21(DE3) cells. The protein was initially extracted using a combination of high concentrations of urea, high pH levels, and multiple sonification steps to remove the tTrx from inclusion bodies formed during expression. This procedure pro

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7

Björkhem, Bergman Linda. "Thioredoxin reductase and selenium in carcinogenesis and multidrug resistance /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-954-4/.

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8

Zhong, Liangwei. "Selenium in mammalian thioredoxin reductase /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4243-9/.

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9

Callister, Matthew Eric James. "Thioredoxin and the inflammatory response." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414905.

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10

Rozell, Björn. "Immunohistochemical studies of the thioredoxin system." Göteborg : Dept. of Histology, University of Göteborg, 1987. http://catalog.hathitrust.org/api/volumes/oclc/17242526.html.

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11

Sze, Jun Hui. "Targeting Thioredoxin Reductase in Multiple Myeloma." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/392857.

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Multiple myeloma (MM) is a clonal plasma B-cell neoplasm characterised by the presence of uncontrolled proliferation of antibody-secreting plasma cells in the bone marrow. Despite therapeutic advancements, MM remains incurable due to its low median survival rate and nearly all patients will eventually relapse regardless of the frontline regimen they receive. Thus, alternative therapeutic strategies that target the pathogenic and resistance mechanisms of MM need to be developed to improve overall survival in MM patients. Cancer cells generally have higher metabolic demands due to their high pro

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12

James, Paul Brian Charles. "Investigation into peroxiredoxin and interactions in the peroxiredoxin peroxide scavenging system." Thesis, University of Exeter, 2010. http://hdl.handle.net/10036/3162.

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Peroxiredoxins are a family of multifunctional enzymes that are able to protect the cell against oxidative stress. Peroxiredoxins form part of a recently discovered peroxide scavenging system along with thioredoxin, thioredoxin reductase and sulfiredoxin. This study describes the purification of a recombinant human peroxiredoxin II from human erythrocytes. The original recombinant clone contained a point mutation at the fourth residue from glycine to valine and a number of problems were encountered with aggregation during purification. Reverting back to the original amino acid sequence allowed

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13

Nalvarte, Ivan. "Functional characterization of cytosolic and mitochondrial thioredoxin reductases /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-919-X/.

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14

Jauregui, Jose. "Auranofin Targets Thioredoxin Reductases in Trichomonas vaginalis." Scholarly Commons, 2017. https://scholarlycommons.pacific.edu/uop_etds/2976.

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Trichomonas vaginalis is an anaerobic, parasitic protozoan, responsible for trichomoniasis, the world’s most common, non-viral sexually transmitted infection. Lacking many of the defenses present in other organisms to combat oxidative stress, Trichomonas vaginalis relies extensively on the thioredoxin system—NADPH, thioredoxin reductase, and thioredoxin—as a means to protect against exposure to excess oxygen. Current trichomoniasis treatment relies exclusively on the 5-nitroimidazole drugs, but fear of drug-resistant strains and allergic reactions to 5-nitroimidazole treatment necessitate th

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15

Damdimopoulos, Anastasios E. "Identification and functional characterization of novel thioredoxin systems /." Stockholm,, 2003. http://diss.kib.ki.se/2003/91-7349-661-8/.

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16

蕭嘉慧 and Ka-wai Siu. "Identification of biological inhibitors of the mammalian thioredoxin system." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221634.

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17

Eckenroth, Brian E. "The Mechanism of High MR Thioredoxin Reductase Investigated by Semisynthesis and Crystallography." ScholarWorks @ UVM, 2007. http://scholarworks.uvm.edu/graddis/73.

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The high Mr (~55 kDa) thioredoxin reductases (TR) characteristic of higher eukaryotes are members of the glutathione reductase (GR) family of pyridine nucleotide disulfide oxidoreductases. These homodimeric enzymes catalyze the reduction of a cognate disulfide substrate. During the enzymatic cycle, reducing equivalents pass from NADPH to the conserved active site disulfide via an enzyme-bound FAD and then to the cognate substrate. TRs are unique in the family as electrons are then transferred to the C-terminal active site of the adjacent molecule as part of a 16 amino acid extension (in place

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18

Loganathan, Usha R. "Characterization of the thioredoxin system in Methanosarcina mazei." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/71334.

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Thioredoxin (Trx) and thioredoxin reductase (TrxR) along with an electron donor form a thioredoxin system. Such systems are widely distributed among the organisms belonging to the three domains of life. It is one of the major disulfide reducing systems, which provides electrons to several enzymes, such as ribonucleotide reductase, methionine sulfoxide reductase and glutathione peroxidase to name a few. It also plays an important role in combating oxidative stress and redox regulation of metabolism. Trx is a small redox protein, about 12 kDa in size, with an active site motif of Cys-X-X-Cys. Th

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19

Matsuo, Yoshiyuki. "Identification of a Novel Thioredoxin-related Transmembrane Protein." Kyoto University, 2001. http://hdl.handle.net/2433/150552.

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20

Ueno, Masaya. "Thioredoxin-dependent redox regulation of p53 mediated-p21activation." Kyoto University, 2000. http://hdl.handle.net/2433/180842.

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21

Nishiyama, Akira. "Identification of thioredoxin-binding protein-2/vitamin D_3 up-regulated protein 1 as a nagative regulator of thioredoxin function and expression." Kyoto University, 1999. http://hdl.handle.net/2433/181259.

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22

Clapper, Erin M. "Investigating Intrinsic and Extrinsic Mechanisms of Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukaemia." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/409643.

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myeloid leukaemia (CML) is a myeloproliferative disorder that is responsible for 15% of all adult leukaemia cases. While the initial stages of CML are relatively mild, the terminal stage of disease, known as blast crisis, has an average survival time of approximately 12 months. CML is caused by a reciprocal chromosomal translocation that results in the production of a constitutively active non-receptor tyrosine kinase, known as bcr-abl. Bcr-abl activates a wide variety of cell proliferation and survival pathways, and this leads to abnormal cell growth and therefore cancer. Due to the involveme

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23

McKown, Richard Dwayne. "Localization and partial immunological characterization of Fasciola hepatica Thioredoxin." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1401.

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This study reports the localization and partial characterization of thioredoxin from the parasitic trematode Fasciola hepatica. Snails (Pseudosuccinia columella) were raised in culture and infected with F. hepatica so that Western blotting and immunohistochemical techniques could be utilized to determine the presence of thioredoxin in different stages of the parasites development. The results of these experiments showed that thioredoxin was present in the tegument, gut epithelium, excretory canal epithelium and sperm, of the adult parasite as well as in the tegument and gut of the redia and

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24

Chiu, Joyce Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Protein engineering of DNA polymerase I: thioredoxin dependent processivity." Awarded by:University of New South Wales. School of Biotechnology and Biomolecular Sciences, 2005. http://handle.unsw.edu.au/1959.4/23077.

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DNA polymerases are found in a diverse range of organisms, prokaryotes, eukaryotes, viruses and bacteriophage. T7 DNA polymerase is a replicative enzyme from E. coli bacteriophage T7. It relies on the thioredoxin binding domain (TBD) of phage gene 5 protein (gp5) and E. coli thioredoxin (Trx) for processive replication of phage DNA. Although T7 DNA polymerase is processive, it is also thermolabile. In order to design a thermostable and processive DNA polymerase, the structural stabilities of the TBD and Trx were studied in respect to their binding affinity and affect on enzyme processivity. An

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25

Ren, Bin. "Crystallographic studies on redox enzymes containing the thioredoxin fold /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3302-2/.

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26

Lee, Chi-wai. "Impact of gestational diabetes mellitus on placental thioredoxin system." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39558897.

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27

Leaver, Susannah. "Intracellular and extracellular thioredoxin implications for the inflammatory response." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537565.

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28

Lee, Chi-wai, and 李志慧. "Impact of gestational diabetes mellitus on placental thioredoxin system." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39558897.

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29

Takashima, Yuichiro. "Differential expression of glutaredoxin and thioredoxin during monocytic differentiation." Kyoto University, 2000. http://hdl.handle.net/2433/151447.

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30

Eftekharpour, Eftekhar. "Glutathione dependent and thioredoxin dependent peroxidase systems in neural cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63863.pdf.

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31

Ho, Ian-ian. "Does Ras/MEK signaling stimulate the expression of thioredoxin reductase? /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38348123.

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32

Hall, Gareth A. F. "Structural and functional analysis of thioredoxin and associated inhibitor complexes." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495589.

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The thioredoxin redox system, consisting of the thioredoxin protein, thioredoxin reductase and NADPH, is found in both prokaryotic and eukaryotic cells. This essential redox system is known to be important in a multitude of biological functions, including cell cycle regulation and maintainuig an intracellular reduced state. The crystallisation of thioredoxin and thioredoxin-complex structures, covered in this study, has allowed for a detailed analysis of the active site region for the application of drug targeting. understanding of the specific requirements that thioredoxin has for its target

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33

Ho, Ian-ian, and 何欣欣. "Does Ras/MEK signaling stimulate the expression of thioredoxin reductase?" Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011217.

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34

Floen, Miranda J. "Thioredoxin-1| Identification of redox substrates and response to hyperoxia." Thesis, University of South Dakota, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10132866.

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<p> Bronchopulmonary dysplasia (BPD) is a serious respiratory complication for the preterm newborn characterized clinically by prolonged respiratory distress and histologically by alveolar simplification and decreased pulmonary vasculature. The development of BPD is well linked to oxidative stress suffered by the newborn as a result of a preterm fetal-neonatal transition, supplemental oxygen, infection, increased inflammation, and mechanical ventilation. Damage suffered by oxidative stress may be through direct mechanisms or through alteration of redox¬sensitive pathways involved in cell d

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35

Tan, Aiguo. "Thioredoxin-1 attenuates indomethacin-induced gastric mucosal injury in mice." Kyoto University, 2008. http://hdl.handle.net/2433/135862.

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36

Hanschmann, Eva-Maria [Verfasser]. "Thioredoxin family proteins in physiology and disease / Eva-Maria Hanschmann." Marburg : Universitätsbibliothek Marburg, 2011. http://d-nb.info/1016617615/34.

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37

Zurek, Mark [Verfasser]. "Regulation der kardialen Myofibroblastendifferenzierung – Rolle von Thioredoxin-1 / Mark Zurek." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1212238664/34.

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38

Dai, Shaodong. "Structural and functional studies of NADPH and ferredoxin dependent thioredoxin reductases /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1998. http://epsilon.slu.se/avh/1998/91-576-5480-8.gif.

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39

Attarian, Rodgoun. "Detoxification of glutathione and nitrosoglutathione by thioredoxin system of Mycobacterium tuberculosis." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/11175.

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Tuberculosis is the leading cause of mortality due to a single pathogenic infection. Its etiological agent, Mycobacterium tuberculosis infects, resides and multiplies within human alveolar macrophages. It is exposed to reactive oxygen intermediates and reactive nitrogen intermediates (RNI) such as nitric oxide (NO) produced within phagosomes and granulomas against invading pathogens. Therefore, proliferation of M. tuberculosis within the host depends on its strategies to counteract the onslaught of these intermediates. One example is recruitment of the thioredoxin system as one of the most pro

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40

Petry, Sebastian Friedrich [Verfasser]. "Thioredoxin family proteins in the db/db mouse / Sebastian Friedrich Petry." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1077438826/34.

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41

Findlay, Victoria Jane. "The role of thioredoxin peroxidases in the yeast oxidative stress response." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391954.

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42

Susanti, Dwi. "Sulfite reductase and thioredoxin in oxidative stress responses of methanogenic archaea." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/51423.

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Methanogens are a group of microorganisms that utilize simple compounds such as H2 + CO2, acetate and methanol for the production of methane, an end-product of their metabolism. These obligate anaerobes belonging to the archaeal domain inhabit diverse anoxic environments such as rice paddy fields, human guts, rumen of ruminants, and hydrothermal vents. In these habitats, methanogens are often exposed to O2 and previous studies have shown that many methanogens are able to tolerate O2 exposure. Hence, methanogens must have developed survival strategies to be able to live under oxidative stres

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43

Kawasaki, Kimio. "Helicobacter felis-induced gastritis was suppressed in mice overexpressing thioredoxin-1." Kyoto University, 2005. http://hdl.handle.net/2433/144494.

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44

Okubo, Kenichi. "Amelioration of ischemia-reperfusion injury by human thioredoxin in rabbit lung." Kyoto University, 1997. http://hdl.handle.net/2433/202158.

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45

Andres, Allen Mariano. "Metabolic role of thioredoxin-interacting protein in facilitating the fasting response." Diss., [La Jolla] : [San Diego] : University of California, San Diego ; San Diego State University, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3369671.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2009.<br>Title from first page of PDF file (viewed September 15, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 99-119).

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46

Karlenius, Therese Christina. "Regulation of the Thioredoxin System under Hypoxia and Different Oxygen Conditions." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/365526.

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The thioredoxin system is one of the key antioxidant systems in the cell and is crucial for cell survival. It is comprised of thioredoxin and thioredoxin reductase and plays important roles in maintaining the redox homeostasis within the cell. The thioredoxin system is upregulated under conditions of oxidative stress to help re-establish the redox environment. This induced expression is mainly regulated through the action of regulatory elements present in their promoters, especially the antioxidant responsive element (ARE) via binding of the Nrf-2 transcription factor. The regulation of the th

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47

Bhatia, Maneet. "Inhibition of the Thioredoxin System: Regulation by the Cancer Cell Environment." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367262.

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The oxygen environment in tumors is not static and involves constant cycling between hypoxic and re-oxygenation phases, a phenomenon known as intermittent hypoxia. Hypoxic and redox pathways are upregulated in response to intermittent hypoxia. The thioredoxin system, comprised of thioredoxin and thioredoxin reductase, is one of the main antioxidant systems, while hypoxia inducible factor 1 (HIF1) is the major hypoxia responsive system. High levels of both the thioredoxin system proteins and HIF1α have been correlated with extremely aggressive and highly metastatic tumors. Both these systems ha

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48

Wang, Sicong. "Investigating cellular responses after inhibition of the thioredoxin system in lymphoma." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/417233.

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Lymphoma is a haematological cancer that develops in the lymphatic system. Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) are the two main lymphoma subtypes. HL is commonly diagnosed in young people and in adults over the age of 55. NHL is a more aggressive subtype than HL, and it accounts for approximately 90% of all lymphoma cases. Despite the development of different chemotherapy regimens for lymphoma treatment, 40-50% of lymphoma patients fail to achieve long-term survival rates because some patients do not respond to chemotherapy or they become resistant to the treatment. Additi

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49

Nonn, Larisa. "The role of the mitochondrial thioredoxin-2 system in cell function." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/289903.

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The hypothesis upon which this research is based is that the mitochondrial thioredoxin-2 system, which consists of mitochondrial thioredoxin-2 (Trx-2), mitochondrial thioredoxin reductase (TrxR-2) and mitochondrial thioredoxin peroxidase (Prdx-3), protects cells against apoptosis and regulates cell growth via mitochondrial redox homeostasis. Trx-2 mRNA was found expressed in a panel of cancer cell lines and Trx-2 protein is localized exclusively to the mitochondria. An alternate splice form of Trx-2 lacking exon 2 was identified that does not yield protein. Forced overexpression of Trx-2 in ce

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50

SABELLI, RENATO. "Organ sulfur compounds and interactions with the detoxification and redox system enzymes." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1194.

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Molti composti organici contenenti zolfo (OSCs) ritrovati nell'aglio sono in grado di indurre apoptosi in varie linee tumorali [80]. Recentemente, è stato ritrovato nella fase acquosa dell'aglio bollito il 2-propenil tiosolfato (2-PTS), ed è stato visto essere in grado di indurre apoptosi in più linee tumorali, tramite la produzione di ROS intracellulari [16, 75]. Inoltre, recenti lavori [38, 39, 75] hanno messo in evidenza il fatto che la tioalchenilazione degli enzimi sia una delle cause dell'effetto citotossico di questi composti. Sulla base di ciò è stato valutato l'effetto citotossico de

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