Articles de revues : « Tissu de granulation »

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Gangl, Monika. « Les complications associées aux chirurgies de pied ». Le Nouveau Praticien Vétérinaire équine 16 (octobre 2022) : 114–19. http://dx.doi.org/10.1051/npvequi/2023001.

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Les chirurgies du pied sont fréquentes en pratique équine, et couvrent tout le spectre d’un simple débridement d’abcès de pied jusqu’aux techniques d’ostéosynthèse. Les complications les plus souvent rencontrées sont l’hémorragie, l’infection, et les problèmes de cicatrisation telles que la déhiscence, la formation d’un tissu de granulation excessif et la déformation de la boîte cornée. L’hémorragie n’impacte qu’exceptionnellement le pronostic vital, mais diminue la visibilité du champ chirurgical. Les infections persistantes et surinfections sont fréquentes, le pied se trouvant à proximité du sol. Les problèmes de cicatrisation s’expliquent souvent par une mobilité trop importante. Ces complications peuvent être évitées ou gérées par des moyens assez simples comme un garrot, une préparation méticuleuse du pied, une bonne hygiène, et une immobilisation par un plâtre de pied et des ferrures. En revanche, la négligence de ces mesures peut entraîner des défauts persistants et des boiteries chroniques, et mener à l’échec de la chirurgie.

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Bogdanov, S. B., V. A. Aladina, D. N. Marchenko, A. V. Polyakov, K. I. Melkonyan, I. V. Gilevich et Yu A. Bogdanova. « SURGICAL ASPECTS OF FULL-THICKNESS SKIN AUTOGRAFT ENGRAFTMENT ON A GRANULATING WOUND ». Innovative medicine of Kuban, n^o 2 (2 juin 2020) : 41–45. http://dx.doi.org/10.35401/2500-0268-2020-18-2-41-45.

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Background. The paper presents the clinical results of treating patients using full-thickness skin autografts for granulating wounds.Objective. To study the surgical aspects of full-thickness skin autograft engraftment on a granulating wound. Material and methods In traumatology and burn research, to achieve the best cosmetic results, transplantation methods of free full-thickness skin autografts are used. In the Regional Clinical Hospital #1, a method of skin grafting with a full-thickness autograft was developed, which allows to close the defect in the conditions of a purulent wound: granulations are excised before skin transplantation, and a vacuum is applied after grafting.Results. Annually, the specialists of the Burn Center of the Scientific Research Institute – Regional Clinical Hospital #1 assist more than 1300 patients. Of these, from 20 to 25 cases are face burns. 132 patients with burns of the face have been admitted to the hospital over the past 10 years. 37 patients underwent plastic surgery with a full-thickness skin autograft. The authors presented the technology for the surgical treatment of deep burns on the face. After cleansing the wound from areas of necrosis and granulations, usually 20 days after the injury, the upper layers of granulation tissue are removed with a dermatome parallel to the skin surface, to a depth of 1–2 mm. Then, plastic surgery with the free full-thickness skin autograft is carried out on the skin of the face with the formation of cuts for the nose, mouth, eyes. The wound is tightly bandaged with 5–7 rounds of a medical bandage or a vacuum-assisted closure is applied.Conclusion. In case of traumatic skin detachment, plastic surgery according to Krasovitov should be performed in the first hours from the moment of injury. Our study allows transplantation of a full-thickness skin graft to granulating wounds as well. After 5 days, the condition of skin autografts is assessed at the first dressing. Their engraftment is observed on the 7th day. In the postoperative period, scar tissue does not form.

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Hasan, Masroor, Shafquat Hussain Khundkar, Md Enamul Kabir et SM Shakwat Hossain. « A comparative study of split thickness skin graft take on chronic wounds with and without surgical removal of granulation tissue from the recipient bed ». Journal of Armed Forces Medical College, Bangladesh 9, n^o 2 (2 février 2015) : 49–53. http://dx.doi.org/10.3329/jafmc.v9i2.21826.

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Introduction: In most of the patients with chronic granulating wounds split skin grafting is the preferred option for coverage of the wounds. Split skin grafts may be applied directly on the granulation tissue or it may be applied after complete removal of granulation tissue. Opinions are divided on this issue. Objectives: To compare the skin take between the split thickness skin grafting on chronic wounds after removal and without removal of granulation tissue in the same patient. Methods: This is a longitudinal type of follow up and comparative study and was carried out in the Department of Plastic Surgery of Dhaka Medical College Hospital, Dhaka between the periods of January 2008 up to December 2009. The study population included the patients with chronic wounds attending the Department of Plastic Surgery of Dhaka Medical College Hospital and in the Plastic Surgery Department of Combined Military Hospital, Dhaka. In this study a total of 57 patients with clinically non infected chronic granulating wounds requiring skin graft were selected. Among which 50 patients were from Dhaka Medical College Hospital and 7 patients were from Combined Military Hospital, Dhaka. In the same patient wounds were divided into Group A and B. In Group A granulation tissue were removed before skin grafting and in Group B the granulation tissues were not removed before skin grafting and skin graft was applied directly on the granulation tissue. 49 JAFMC Bangladesh. Vol 9, No 2 (December) 2013 Results: In the final skin take assessment it was found that in Group A, 49 (86.0%) patients had a take between 91-100% and 8 (14.0%) patients had a take between 81-90%. None of the patients in this group had a take <80%. In Group B, 30(52.6%) patients had a take between 91-100% and 18(31.6%) patients had a take between 81-90%. There were 9 (15.8%) patients who had a take of <80% and among them 02 patients had a take <70%. Statistically this was significant. Conclusion: Whenever the granulation tissue is removed, the recipient bed has a better chance of skin take as far as infection is concerned. But it must be ensured that haemostasis is achieved before application of the graft. DOI: http://dx.doi.org/10.3329/jafmc.v9i2.21826 Journal of Armed Forces Medical College Bangladesh Vol.9(2) 2013

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Polyovyy, V. P., B. Khorshani, V. V. Petrynych, P. V. Kyfyak, O. V. Tkachuk et R. I. Sydorchuk. « FEATURES OF THE EARLY PROCESS IN DIABETIC FOOT SYNDROME ». Kharkiv Surgical School, n^o 2 (20 avril 2020) : 21–25. http://dx.doi.org/10.37699/2308-7005.2.2020.04.

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Summary. Diabetic foot syndrome (DFS) is one of the most common surgical diseases. The aim of the study: to determine the features of the wound process in the DFS. Materials and methods. Multimodal pathomorphological study of biopsy material in 120 cases of surgical treatment of DFS was performed. Results and discussion. During the development of the wound process in the DFS, histologically determined reduction of edema, cellular infiltration, microcirculatory disorders in the marginal area of the wound in the dynamics of treatment. It is found in granulation tissue and in the dermis adjacent to intact skin, a large number of hairy cells. Microcirculatory disorders are expressed in the form of venular plethora, the phenomena of stasis in the capillaries, hemolysis of erythrocytes and the marginal standing of the formed elements in the venules and capillaries. The DFS is characterized by the appearance of foci of destruction and lysis of the newly formed epithelium, which is not observed in the normal wound process. Conclusions. The formation of granulation tissue is slow, mainly in the form of unformed connective tissue without the formation of classic granulations.

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Smith, W. K., et A. G. Pfleiderer. « The use of the KTP laser in the management of hypertrophic tracheal mucosa and granulation tissue around Provox® valve protheses ». Journal of Laryngology & ; Otology 117, n^o 1 (janvier 2003) : 60–62. http://dx.doi.org/10.1258/002221503321046667.

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The development of hypertrophic mucosa and granulation tissue around a tracheo-oesophageal fistula voice prosthesis is a commonly encountered problem occurring in 15–20 per cent of patients. Upsizing of the voice prosthesis as well as cautery (silver nitrate and electocautery) are used to counteract this problem to a varying degree of success. The use of the CO2 laser has been mentioned by some authors but details of the method and results have not been published. We report the successful use of the KTP laser for removing such granulations whilst retaining the valve and discuss the reasons why this method should be considered.

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Bansal, Mohan. « Granular myringitis : current status of management ». International Journal of Otorhinolaryngology and Head and Neck Surgery 1, n^o 2 (4 octobre 2015) : 55. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20150900.

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The Granular Myringitis (GM) is not uncommon though in medical literature it has been reported among the rarer conditions. The aim of this article is to review the clinical features and management of Granular Myringitis (GM). GM is characterized by granulation tissue on the outer surface of the Tympanic Membrane (TM) with or without the involvement of deep bony External Auditory Canal (EAC). The granulations are either localized or diffuse. The granulations over tympanic membrane continue to grow slowly for years. The ensuing fibrosis in patients with granulations of deep bony meatal wall can result into an atresia of the deep bony EAC. The presenting symptom of GM is an ear discharge which may be foul-smelling. However many patients have a sensation of fullness, irritation, mild pain or itching in the ear. If perforation occurs the underlay perichondrium or temporalis fascia grafting is done. In some of the refractory cases granulations are removed and the raw area is covered with skin. Many patients respond well to meticulous microscopic aural toilet and topical antibiotic and steroid ear drops. If patients do not respond then application of topical caustic agents are employed.

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Conegero, Celso Ivan, et Renato Paulo Chopard. « Tridimensional architecture of the collagen element in the arachnoid granulations in humans : a study on scanning electron microscopy ». Arquivos de Neuro-Psiquiatria 61, n^o 3A (septembre 2003) : 561–65. http://dx.doi.org/10.1590/s0004-282x2003000400007.

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The arachnoid granulations of adult individual of both sexes were studied through scanning electron microscopy. The dura mater and arachnoid meninges of individuals were collected at the Service of Death Verification of São Paulo - USP and fixed in Karnovsky solution. After this period the material was prepared for analysis in electron microscope. Our results demonstrated that the arachnoid granulations are formed by a pedicle, body and apex, being surrounded by a capsule of connective tissue, which in turn is composed of, basically, bundles of collagen fibers that line pores of different shapes and sizes. The smaller pores are lined by tiny bundles and are located at the apical region of the granulation and the larger are lined by thicker bundles and are located at the lateral regions. In the body we verified that the bundles of collagen fibers compose a fibrous meshwork and in some regions these bundles have circular orientation, forming pores similar to those found at the region of the capsule.

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Bigbie, R. B., J. Schumacher, S. F. Swaim, R. C. Purohit et J. C. Wright. « Effects of amnion and live yeast cell derivative on second-intention healing in horses ». American Journal of Veterinary Research 52, n^o 8 (1 août 1991) : 1376–82. http://dx.doi.org/10.2460/ajvr.1991.52.08.1376.

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Summary Equine amnion and live yeast cell derivative were evaluated as a biological dressing and as a topical wound medicament respectively, in the treatment of granulating wounds of the distal portion of the limbs of horses. Wounds measuring 2.5 × 2.5 cm were created on the dorsomedial aspect of the metacarpal and metatarsal region of all 4 limbs of 9 horses. Each wound was assigned randomly to 1 of 3 treatment groups: group C, treated with a nonadherent bandage as a control; group A, treated with amnion beneath a nonadherent bandage; and group L, treated with live yeast cell derivative beneath a nonadherent bandage. Rates of contraction and epithelialization were not significantly different among groups. Percentage of epithelialization for group A was significantly greater throughout the study than for the other groups. Number of days to complete healing was significantly less in group A and significantly greater in group L than in group C. Incidence and severity of exuberant granulation tissue were significantly less in group A than in the other 2 groups. Group L had more frequent and severe cases of exuberant granulation tissue than the other 2 groups.

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Ghosh, Ajoy Kumar, Noriyasu Hirasawa, Hiroshi Ohtsu, Takehiko Watanabe et Kazuo Ohuchi. « Defective Angiogenesis in the Inflammatory Granulation Tissue in Histidine Decarboxylase–deficient Mice but not in Mast Cell–deficient Mice ». Journal of Experimental Medicine 195, n^o 8 (8 avril 2002) : 973–82. http://dx.doi.org/10.1084/jem.20011782.

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We have analyzed the role of histamine in the angiogenesis of the granulation tissue in histidine decarboxylase–deficient (HDC−/−) mice, mast cell–deficient mice (WBB6F1-W/WV), and their corresponding wild-type mice (HDC+/+ and WBB6F1+/+). In HDC+/+ mice, subcutaneous implantation of a cotton thread in the dorsum induced granulation tissue formation with angiogenesis, while the topical injection of antivascular endothelial growth factor (VEGF) IgG strongly suppressed them. In HDC−/− mice which showed lower VEGF levels in the granulation tissue, there was notably less angiogenesis and granulation tissue formation than in HDC+/+ mice. The topical injection of histamine or the H2 agonist dimaprit rescued the defective angiogenesis and granulation tissue formation in HDC−/− mice. There was no significant difference in the granulation tissue formation and angiogenesis between WBB6F1-W/WV and WBB6F1+/+ mice. In addition, macrophages in the granulation tissue were found to express HDC. Our findings indicate that histamine derived from nonmast cells plays a significant role in the angiogenesis of the inflammatory granulation tissue.

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Nikonorova, Varvara G., Vladimir V. Krishtop et Tat’yana A. Rumyantseva. « Granulation Tissue as a Type of Connective Tissue (Review) ». Journal of Medical and Biological Research, n^o 2 (10 mai 2022) : 167–79. http://dx.doi.org/10.37482/2687-1491-z098.

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Currently, there is no consensus among scientists on the place of scar tissue and, in particular, granulation tissue in the classification of fibrous connective tissue. This paper aimed to generalize literature data on the structure and development of fibrous scar tissue. It is demonstrated that granulation tissue is mostly composed of myofibroblasts, along with fibroblasts, as well as old fibroblasts, endothelial cells, and immune cells. Myofibroblasts are characterized by a developed cytoskeleton represented by stress fibers, which ensures active migration of these cells and remodelling of the surrounding intercellular substance. The developed synthetic apparatus of the myofibroblast, in addition to synthesis of the intercellular substance, provides cell paracrine activity, which maintains the homeostasis of the cellular components of granulation tissue. The intercellular substance is represented by type III collagen fibers; elastic fibers are absent. The ground substance has a high degree of hydration and low stiffness and is rich in glycosaminoglycans, collagenases and fibronectin; this greatly facilitates the migration of myofibroblasts, endotheliocytes and fibrocytes. The ability of the intercellular substance to accumulate growth factors plays an important role in the transdifferentiation of fibrocytes into myofibroblasts. The blood vessels of the granulation tissue are the source of fibrocytes, which play a key role in the formation of granules of the newly formed tissue around the vessel. Myofibroblast apoptosis triggers the differentiation of granulation tissue into dense fibrous loose connective tissue. At the same time, type III collagen is replaced by type I collagen, elastin fibers appear, angiogenesis is inhibited, and mechanisms providing sympathetic innervation of connective tissue are triggered. Thus, granulation tissue can be considered as temporary connective tissue, which is one of the examples of dedifferentiation that occurs not only at the cellular, but also at the tissue level.

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Shvets, O. V., Tatiana V. Gaivoronskaya, E. E. Esaulenko et N. I. Bykova. « Optimization of healing in patients with odontogenic phlegmon of the maxillofacial region ». Russian Journal of Dentistry 24, n^o 6 (15 décembre 2020) : 387–90. http://dx.doi.org/10.17816/1728-2802-2020-24-6-387-390.

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Aim. This study aims to increase the efficiency of the wound process in patients with odontogenic phlegmons of the maxillofacial region by using energotropic and antioxidant agents. Material and methods. The clinical study included 42 patients with odontogenic phlegmons of the maxillofacial region. The patients were divided into two groups: comparison group (patients received traditional treatment) and main group (patients received treatment with Cytoflavin in the treatment regimen). Results. In the main group, the appearance of the first granulations occurred 2.1 times faster (on average on the 3rd day) in comparison with the granulation tissue in patients of the comparison group. Signs of edge epithelialization of wounds appeared almost 3 days earlier (on average on the 6th day) in the main group than in the comparison group; on the 7th day, secondary sutures were already applied, which was 1.6 times faster than the same parameter group 2, clearly suggesting the acceleration of reparative processes. Conclusion. The dynamics of clinical manifestations indicates the comparative effectiveness of using Cytoflavin as part of complex therapy. This finding is confirmed by the accelerated terms of wound healing, the appearance of granulations, epithelialization of the wound edges, and the imposition of secondary sutures.

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Ito, Kiyoshi, Tetsuyoshi Horiuchi, Kiyomitsu Oyanagi, Tetsuo Nomiyama et Kazuhiro Hongo. « Comparative study of fibrin and chemical synthetic sealant on dural regeneration and brain damage ». Journal of Neurosurgery : Spine 19, n^o 6 (décembre 2013) : 736–43. http://dx.doi.org/10.3171/2013.8.spine12998.

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Object Several materials, such as polyethylene glycol (PEG) hydrogel and fibrin glue, have been used to seal dural incisions after brain and spinal surgeries. Although the use of PEG sealant is gaining popularity, it can be associated with postoperative cerebrospinal fluid leakage and infection. However, the reasons for this association are currently unknown. The present study aimed to investigate the effects of PEG sealant and fibrin glue on wound healing and brain damage in vivo. Methods Oval-shaped bone defects and dural defects were created bilaterally over the parietal lobes of 22 Japanese white rabbits. The dural defects were covered with 0.5 ml of fibrin glue on one side and 0.5 ml of PEG sealant on the other side. Dural regeneration and brain damage were investigated in each harvested brain and dura mater using light microscopy. Results Dural regeneration was more effective in the presence of fibrin glue than it was with PEG sealant (p = 0.014). Of the 22 rabbits, 11 showed thick (Grades ++ and +++) dural regeneration by 28 days postsurgery in the hemisphere where fibrin glue was used, whereas Grade +++ dural regeneration was not observed in the PEG hydrogel hemisphere, and only 4 rabbits showed Grade ++ regeneration. Abscess and granulation formation also tended to be more severe when PEG hydrogel sealant was used. No Grade ++ granulation/abscess formation was observed with fibrin glue, and Grade + was only observed in 13 of 22 rabbits. Conversely, with PEG hydrogel sealant, only 2 rabbits did not show granulation/abscess formation, and Grade +, ++, and +++ granulation/abscess formation was observed in 8, 7, and 5 rabbits, respectively. The extent of cortical damage was significantly greater in rabbits with abscesses and granulations, compared with rabbits without these lesions (p = 0.007). Conclusions Dural regeneration tended to occur more rapidly with fibrin glue, whereas granulation was more likely with PEG hydrogel sealant, which led to postoperative complications. Histological analysis indicated that PEG hydrogel sealant inhibited the normal tissue healing process and that outcomes were improved by the use of fibrin glue.

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Higgins, E. M., J. R. Hughes, S. Snowden et A. C. Pembroke. « Cyclosporin-induced periungual granulation tissue ». British Journal of Dermatology 132, n^o 5 (29 juillet 2006) : 829–30. http://dx.doi.org/10.1111/j.1365-2133.1995.tb00737.x.

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Medrek, Sarah K., Donald R. Lazarus, Neda Zarrin-Khameh, Nadia Mohyuddin et Venkata Bandi. « Obstructive Post-tracheotomy Granulation Tissue ». American Journal of Respiratory and Critical Care Medicine 196, n^o 5 (septembre 2017) : e12-e13. http://dx.doi.org/10.1164/rccm.201703-0468im.

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Bertone, Alicia L. « Management of Exuberant Granulation Tissue ». Veterinary Clinics of North America : Equine Practice 5, n^o 3 (décembre 1989) : 551–62. http://dx.doi.org/10.1016/s0749-0739(17)30574-6.

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Wilmink, Jacintha M., et P. René Van Weeren. « Treatment of exuberant granulation tissue ». Clinical Techniques in Equine Practice 3, n^o 2 (juin 2004) : 141–47. http://dx.doi.org/10.1053/j.ctep.2004.08.012.

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Sandreva, Tatjana, Anette Bygum et Vibeke Vestergaard. « Peristomal granulation tissue–like papules ». Journal of the American Academy of Dermatology 72, n^o 1 (janvier 2015) : e11-e12. http://dx.doi.org/10.1016/j.jaad.2014.05.066.

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HØLUND, BERIT, INGE CLEMMENSEN, PETER JUNKER et HANS LYON. « FIBRONECTIN IN EXPERIMENTAL GRANULATION TISSUE ». Acta Pathologica Microbiologica Scandinavica Series A :Pathology 90A, n^o 1-6 (19 août 2009) : 159–65. http://dx.doi.org/10.1111/j.1699-0463.1982.tb00077_90a.x.

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Kocoshis, Samuel A., Gerry Hennies, Kim Klotz, Kathie Yeary et Philip E. Putnam. « Internal Granulation Tissue of Gastrostomies ». American Journal of Gastroenterology 100 (septembre 2005) : S378. http://dx.doi.org/10.14309/00000434-200509001-01039.

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Häkkinen, Lari, Hannu Larjava et Leeni Koivisto. « Granulation tissue formation and remodeling ». Endodontic Topics 24, n^o 1 (mars 2011) : 94–129. http://dx.doi.org/10.1111/etp.12008.

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Hirotsu, Kelsey, Swati Kannan et Shang I. Brian Jiang. « Treatment of Hypertrophic Granulation Tissue ». Dermatologic Surgery 45, n^o 12 (décembre 2019) : 1507–16. http://dx.doi.org/10.1097/dss.0000000000002059.

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Gniadecki, R., et J. Serup. « Enhancement of the granulation tissue formation in hairless mice by a potent vitamin D receptor agonist – KH 1060 ». Journal of Endocrinology 141, n^o 3 (juin 1994) : 411–15. http://dx.doi.org/10.1677/joe.0.1410411.

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Abstract KH 1060 is a 20-epi analogue of 1,25-dihydroxyvitamin D3 and a potent agonist of the vitamin D receptor. Our recent finding that it stimulates glycosaminoglycan synthesis and transforming growth factor-β1 (TGF-β1) expression in normal skin provided a rationale for investigating its influence on the process of wound healing. Normal and betamethasone-impaired granulation tissue formation was studied in a polytetrafluoroethylene dead space model in hairless mice. The application of KH 1060 increased the indexes of fibroplasia and cellularity ([3H]thymidine incorporation and DNA concentration) of the betamethasone-impaired granulation tissue. Collagen production and deposition, measured as hydroxyproline synthesis and concentration in the granulation tissue, were also increased. The effect of KH 1060 on normal connective tissue repair was less pronounced; DNA and hydroxyproline concentrations in granulation tissue were unchanged. KH 1060 strongly stimulated the expression of TGF-β1 in betamethasone-impaired granulation tissue. Thus, it effectively reversed the deleterious effect of betamethasone on granulation tissue. The hyperproliferative response to this vitamin D analogue might be related to the direct stimulation of the vitamin D receptors in the granulation tissue, while the increased collagen synthesis and deposition was probably caused indirectly, via stimulation of TGF-β1. Journal of Endocrinology (1994) 141, 411–415

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Wai, Clifford Y., Mikio A. Nihira, Peter G. Drewes, Joe S. Chang, Momin T. Siddiqui et David L. Hemsell. « Actinomyces Associated With Persistent Vaginal Granulation Tissue ». Infectious Diseases in Obstetrics and Gynecology 13, n^o 1 (2005) : 53–55. http://dx.doi.org/10.1155/2005/252691.

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Background:We report a case of symptomatic actinomycosis associated with vaginal suture erosion and granulation tissue refractory to conservative management, in an outpatient setting.Case:Three months after total vaginal hysterectomy and uterosacral ligament vaginal vault suspension, a woman complained of painless, intermittent vaginal discharge and spotting. Despite cauterization of granulation tissue, vaginal spotting persisted for another month. On re-examination, braided polyester suture that was found underlying the granulation tissue was removed. Recurrent symptoms, together with a biopsy revealing actinomycetes, prompted a trial of oral penicillin VK. With persistent symptoms and discomfort during attempts in the outpatient clinic, the woman eventually required suture removal in the operating room. Her symptoms subsequently resolved without recurrence, and no further antibiotic treatment was required.Conclusions:Actinomyces may be associated with persistent granulation tissue and vault suspension suture material. In rare circumstances, when tissue debridement and suture removal in the clinic is unsatisfactory, surgical intervention in the operating room may be necessary. Ten days of antibiotic therapy alone did not eradicate the granulation tissue, and symptoms resolved only after complete removal of the underlying permanent suture.

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ZHANG, Jie, Ting WANG, Juan WANG, Ying-hua PEI, Min XU, Yu-ling WANG, Xia ZHANG et Chen WANG. « Effect of three interventional bronchoscopic methods on tracheal stenosis and the formation of granulation tissues in dogs ». Chinese Medical Journal 123, n^o 5 (mars 2010) : 621–27. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.2010.05.021.

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Background Therapeutic approaches for tracheal stenosis caused by the formation of exuberant granulation tissues usually include electrocautery, mechanical dilation, laser therapy, argon plasma coagulation (APC), cryotherapy and stent placement. However, restenosis after stent insertion remains a significant limitation. We examined the efficacy of three different approaches, including induction of mechanical lesions, APC performed with different powers or durations and cryotherapy, to identify the method that limited the formation of granulation tissue. Methods Twelve specially bred research mongrel dogs were divided into three groups. In group 1 (four dogs) mild (procedure 1; two dogs) or moderate (procedure 2; two dogs) damage was induced mechanically. Group 2 (six dogs) received APC at different powers or durations (procedure 3: 30 W, 1 cm/s; procedure 4: 30 W, 2 cm/s; procedure 5: 25 W, 3 cm/s). Group 3 (two dogs) received cryotherapy (procedure 6: two freeze-thaw cycles of 30 seconds). Uncovered self-expandable metallic stents were inserted in all dogs to maintain a continuous stimulus to the trachea mucosa. Dogs were monitored for 4 weeks and the relationship between granulation tissue proliferation and method used was analyzed. Results In group 1, granulation tissue growth increased with more severe mechanical damage. The growth of granulation tissue in group 2 was more pronounced than in group 1, and both dogs in procedure 3 died because of severe stenosis. In this group, the formation of granulation tissue decreased with decreasing power and duration. In group 3, no obvious granulation tissue was found at week 4. Conclusions Lesions and stimuli from a foreign body (the stent) are two important factors that lead to overgrowth of granulation tissue. Thermal lesions, such as APC, seem to induce greater granulation tissue growth and cartilage damage compared with mechanical and cryotherapy lesions. Cryotherapy in combination with mechanical dilation may be a safe and effective treatment method for managing tracheal stenosis caused by the formation of granulation tissue.

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Rasheed, Razim Abdul, Mubeena . et K. S. Gangadhara Somayaji. « Pre-operative predictors of ossicular necrosis in chronic otitis media-mucosal type ». International Journal of Otorhinolaryngology and Head and Neck Surgery 5, n^o 2 (23 février 2019) : 396. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20190769.

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Background: Chronic suppurative otitis media can cause a wide range of pathologies in the middle ear that include irreversible mucosal changes, granulation tissue formation, cholesteatoma, tympanosclerosis, and destruction of ossicles. Knowledge regarding ossicular discontinuity before surgery enables the surgeon to be prepared for ossiculoplasty. Objective was to study the pre-operative clinical, audiological and microscopic findings in chronic otitis media mucosal type and correlate preoperative findings with intra-operative ossicular necrosis. Methods: Study design was observational, descriptive and cross sectional study. All patients were subjected to detailed clinical, otoscopic and microscopic examination to assess the size and site of perforation, presence or absence of ear discharge, granulation tissue, tympanosclerosis in the middle ear, exposure of incudostapedeal joint and condition of middle ear mucosa. Pure tone audiogram was also done. All patients underwent tympanoplasty±cortical mastoidectomy and the intraoperative findings of ossicular necrosis were noted. Results: Of the 105 patients, 18(17.1%) had ossicular necrosis. Bivariate analysis showed positive correlation for long standing disease (p=0.004), presence of discharging ear (p=0.014), polypoidal middle ear mucosa (p=0.000) granulations in middle ear (p=0.000) and also when incudostapedeal joint was exposed (p=0.005). Mean Air bone gap was higher with 35 dB in ossicular necrosis and 22.7 dB in intact ossicular chain was also statistically significant (p=0.0001).Conclusions: Ossicular necrosis was best indicated by the presence of polypoidal mucosa, granulation in the middle ear and higher air-bone gap on audiometry. However longer duration of disease, persistent active stage of disease and exposure of incudostapedeal joint were also found to be significant.

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Tondok, Santalia Banne, Demianus Tafor, Sethiana Dewi Ruben, Wanuliana Wanuliana et Nasrah Nasrah. « Utilization of Red Fruit on The Growth of Tissue Granulation in Diabetic Wounds ». Jurnal Penelitian Pendidikan IPA 9, n^o 11 (25 novembre 2023) : 10186–90. http://dx.doi.org/10.29303/jppipa.v9i11.4677.

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The utilization of red fruit on the growth of granulation tissue in diabetic wounds aims to determine the benefits of red fruit which have been scientifically proven through research in Indonesia. Methods: Conducting a literature search using the Google Scholar application and conducting an analysis of the literature included in the inclusion criteria. Results: From the search results and research results which conclude about the benefits of red fruit. Conclusion: The benefits of red fruit on the growth of granulation tissue in diabetic wounds, namely red fruit contains carotene (12,000 ppm), beta-carotene (700 ppm), tocopherol (11,000 ppm). The benefits of red fruit on the growth of granulation tissue also affect diabetic wound healing because granulation tissue is the growth of new tissue that occurs when a wound is undergoing a healing process, consisting of new capillaries and fibroblast cells that fill the cavity. Granulation tissue formation is an important step in the proliferative and healing phase of the wound. Granular tissue is a reddish network that contains capillaries at the base of the wound

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Rioja, E., J.-L. Blanch, A. Borés, M. Bernal-Sprekelsen et I. Vilaseca. « Clinical significance of granulation tissue after transoral laser microsurgery for glottic cancer ». Journal of Laryngology & ; Otology 129, n^o 4 (3 mars 2015) : 377–82. http://dx.doi.org/10.1017/s0022215115000444.

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AbstractBackground:Granulation tissue after transoral laser microsurgery can make it difficult to distinguish between normal healing and tumour recurrence.Materials and methods:We carried out a retrospective analysis of 316 consecutive glottic carcinomas (Tis–T3). Presence of granulation tissue at one and six months was correlated with demographic and clinical data, tumour and surgical characteristics, and tumour relapse.Results:Granulation tissue appeared in 53.8 per cent of patients at month 1, resolving spontaneously in 41.8 per cent. Revision surgery was performed in 60.1 per cent and was effective in 41.1 per cent. At month 6, 14.9 per cent of patients presented with granulation tissue. In 74.5 per cent the tissue was surgically removed and was positive for malignancy in 62.9 per cent. Tumour relapse presented in 29.4 per cent with granulation tissue at month 1 and in 61.7 per cent at month 6 (p= 0.000). Granulation tissue at month 1 correlated with thyroid cartilage exposure and continued smoking. At month 6, granulation tissue correlated with thyroid cartilage exposure, the affected surgical margins and diabetes.Conclusion:Granulation tissue after transoral laser microsurgery is frequent. When it persists at six months, revision surgery is formally recommended.

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Iwanaga, Michitaka, Etsuo Yamamoto et Manabu Fukumoto. « Cathepsin Activity in Cholesteatoma ». Annals of Otology, Rhinology & ; Laryngology 94, n^o 3 (mai 1985) : 309–12. http://dx.doi.org/10.1177/000348948509400318.

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Collagenolytic cathepsin, presumed to play an important role in bone destruction of cholesteatoma, was investigated in cholesteatoma epithelium, subepithelial granulation tissue, skin from the bony external auditory meatus and, temporal bone. The enzyme extracted from tissues was proven to be lysosomal cathepsin B by SDS gel electrophoresis in the use of human type I and type III collagen. α-N-benzoyl-DL-arginine-2-naphthylamide HC1 (BANA) was supposed to be specific for cathepsin B, and so BANA-hydrolase activity was measured as collagen-degrading cathepsin. The results showed that tissues had cathepsin B with its optimal pH 6.0, and that cathepsin B activity revealed a significant increase in the subepithelial granulation tissue. A strong activity of acid phosphatase found in the subepithelial granulation tissue seems to reflect the existence of an active metabolism of substances in the granulation tissue. These findings suggest that collagen is resorbed in the subepithelial granulation tissue in the presence of cholesteatoma.

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Vagholkar, Ketan, Samriddhi Sharma, Subashchandra Subudhi, Deep Mashru, Annvi Shah et Suvarna Vagholkar. « Combination therapy for recurrent ingrown toe nail ». International Surgery Journal 4, n^o 7 (22 juin 2017) : 2345. http://dx.doi.org/10.18203/2349-2902.isj20172619.

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Ingrown toe nail is one of the commonest foot lesion affecting young individuals. The recurrence rate with a variety of treatment modalities continues to be quite significant. Hence the need to develop a comprehensive combination therapy to reduce the recurrence rate. Onychocryptosis or ingrown toe nail is a common and painful form of nail disease. It affects adolescents and young males very commonly. A combination therapy comprising of wedge resection of the nail, matricectomy, phenol cauterization and wedge excision of hyper granulations for recurrent advanced presentation of ingrown toe nail is presented. A 32-year-old male with a history of recurrent ingrown toe nail, operated twice previously presented with an advanced stage of ingrown toe nail. Hypertrophic granulation tissue covered both lateral and medial nail plates. The patient was treated with an integrated surgical approach comprising of wedge resection of medial as well as lateral border of nail ensuring removal of spicules on either side, followed by wedge resection of underlying nail bed. This was followed by phenol cauterization and elliptical excision of hypertrophic granulations. The predisposing factors, natural history and treatment modalities are discussed. Combination therapy is a safe and the best option for recurrent ingrown toe nail. It can also be used as a form of primary treatment in fresh cases to prevent recurrence.

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Larjava, H., J. Heino, V. M. Kähäri, T. Krusius et E. Vuorio. « Characterization of One Phenotype of Human Periodontal Granulation-tissue Fibroblasts ». Journal of Dental Research 68, n^o 1 (janvier 1989) : 20–25. http://dx.doi.org/10.1177/00220345890680010301.

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Human granulation-tissue fibroblasts were cultured from oral chronic inflammatory lesions and compared with fibroblasts of healthy gingival connective tissue with respect to cell-surface sialoglycoproteins, and the synthesis of extracellular matrix components. Granulation-tissue fibroblasts exhibited a slower growth rate and larger size than their controls. Their cell-surface sialoglycoproteins resembled those of the control cells, except that the relative amount of glycoproteins in the 140-kd region was lower. The ratio of mRNAs for proαl(I) and proαl(III) collagen chains was decreased in granulation-tissue fibroblasts, although electrophoretic fractionation of the proteins did not reveal consistent differences in type I/type III collagen ratio. Granulation-tissue fibroblasts secreted into the culture medium a dermatan sulfate proteoglycan with a lower molecular weight. After digestion with chondroitinase ABC, the molecular weight of the core protein appeared to be identical with that of the control fibroblasts, suggesting a difference in the glycosylation of the core protein. These results support the theory that granulation-tissue fibroblasts represent a distinct phenotype of fibroblastic cells.

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SHIMIZU, Hiroki. « Anal Fistula with Inflammatory Granulation Tissue ». Nishi Nihon Hifuka 82, n^o 2 (1 avril 2020) : 73–74. http://dx.doi.org/10.2336/nishinihonhifu.82.73.

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Tan, Yongcheng Benjamin. « Myeloid Sarcoma Masquerading as Granulation Tissue ». International Journal of Surgical Pathology 23, n^o 7 (10 juin 2015) : 553–56. http://dx.doi.org/10.1177/1066896915588931.

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Carlson, Mark A., et Jon S. Thompson. « Wound splinting modulates granulation tissue proliferation ». Matrix Biology 23, n^o 4 (juillet 2004) : 243–50. http://dx.doi.org/10.1016/j.matbio.2004.05.006.

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Puig, Lluis, Abelardo Moreno, Enric Llistosella, Xavier Noguera et J. M. Moragas. « Granulation Tissue Proliferation During Isotretinoin Treatment ». International Journal of Dermatology 25, n^o 3 (avril 1986) : 191–95. http://dx.doi.org/10.1111/j.1365-4362.1986.tb02218.x.

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Carlson, Mark A., Michael T. Longaker et Jon S. Thompson. « Wound splinting regulates granulation tissue survival ». Journal of Surgical Research 110, n^o 1 (mars 2003) : 304–9. http://dx.doi.org/10.1016/s0022-4804(02)00098-7.

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NORWOOD, O'TAR T. « Excessive Granulation Tissue after Hair Transplantation ». Journal of Dermatologic Surgery and Oncology 11, n^o 6 (juin 1985) : 566. http://dx.doi.org/10.1111/j.1524-4725.1985.tb01895.x.

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Sarkisov, D. S., E. G. Kolokol'chikova, R. I. Kaem et A. A. Pal'tsyn. « Vascular changes in maturing granulation tissue ». Bulletin of Experimental Biology and Medicine 105, n^o 4 (avril 1988) : 604–7. http://dx.doi.org/10.1007/bf00841219.

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Hakkinen, L., et H. Larjava. « Characterization of Fibroblast Clones from Periodontal Granulation Tissue in vitro ». Journal of Dental Research 71, n^o 12 (décembre 1992) : 1901–7. http://dx.doi.org/10.1177/00220345920710120901.

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Connective tissues are known to be composed of heterogeneous fibroblast subpopulations. The significance of this heterogeneity in different physiological and pathological conditions is poorly understood. Granulation tissue is formed in connective tissue during wound healing, chronic inflammation, and certain pathological conditions. In this study, heterogeneity of fibroblasts from granulation tissue was investigated by cell-cloning techniques. Granulation-tissue fibroblasts (GTFs) from both chronically inflamed periodontal lesions and healing wound granulation tissue behaved similarly. GTFs showed a more pronounced decrease in proliferative capacity with increasing cumulative population doubling levels (CPDLs) and 30-40% lower cloning efficiency compared with normal gingival fibroblasts (HGFs). Morphologically, cells in GTF cultures were mainly large, whereas HGFs were mainly small in size. Both cell-line types showed heterogeneity in cell morphology. Clones composed of large stellate-like cells predominated in GTF cultures, whereas clones composed of small spindle-shaped or epithelioid cells predominated in HGF cultures. In both cell-line types, the proportion of clones composed of large cells increased with increasing CPDL. These findings show that the properties of the fibroblasts changed during their in vitro life spans. The finding that normal connective tissue and granulation tissues contain morphologically distinct fibroblast clones in different proportions suggests that local factors could stimulate local fibroblasts to differentiate into GTFs. Alternatively, local factors could select some fibroblast subpopulations to overgrow the others to form granulation tissue.

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Morar, I. K., O. I. Ivashchuk, I. S. Davydenko, V. Yu Bodyaka et Yu Ya Chuprovskaya. « Peculiarities of granulation tissue morphology around a netalotransplant in preoperative irrigation of the abdominal cavity ». Experimental and Clinical Medicine 87, n^o 2 (1 octobre 2020) : 4–13. http://dx.doi.org/10.35339/ekm.2020.87.02.01.

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The experiment investigated the influence of preoperative remote gamma therapy on the features of the morphology of granulation tissue around the elements of the reticular allograft of the muscular-aponeurotic layer of the anterior abdominal wall. It is established that the use of preoperative remote gamma therapy distorts the maturation of granulation tissue. There is a probable increase in the percentage of fibroblasts and a decrease in lymphoid cells, polymorphonuclear leukocytes, macrophages, and plasma cells in the granulation tissue, mainly on the 5th and 7th day after surgery. Also on the 7th day of the study there was an increase in the specific volume of collagen fibers, their optical density, as well as the specific volume of blood vessels. Keywords: preoperative gamma therapy, granulation tissue, reticular allograft.

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Sato, Kayoko, Yasuyuki Imai, Nobuaki Higashi, Yosuke Kumamoto, Thandi M. Onami, Stephen M. Hedrick et Tatsuro Irimura. « Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a ». Blood 106, n^o 1 (1 juillet 2005) : 207–15. http://dx.doi.org/10.1182/blood-2004-12-4943.

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Macrophage galactose-type C-type lectins (MGLs), which were recently named CD301, have 2 homologues in mice: MGL1 and MGL2. MGLs are expressed on macrophages and immature dendritic cells. The persistent presence of granulation tissue induced by a protein antigen was observed in wild-type mice but not in mice lacking an endogenous, macrophage-specific, galactose-type calcium-type lectin 1 (MGL1) in an air pouch model. The anti-MGL1 antibody suppressed the granulation tissue formation in wild-type mice. A large number of cells, present only in the pouch of MGL1-deficient mice, were not myeloid or lymphoid lineage cells and the number significantly declined after administration of interleukin 1 α (IL-1α) into the pouch of MGL1-deficient mice. Furthermore, granulation tissue was restored by this treatment and the cells obtained from the pouch of MGL1-deficient mice were incorporated into the granulation tissue when injected with IL-1α. Taken together, MGL1 expressed on a specific subpopulation of macrophages that secrete IL-1α was proposed to regulate specific cellular interactions crucial to granulation tissue formation.

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Jimi, Shiro, Satoshi Takagi, Francesco De Francesco, Motoyasu Miyazaki et Arman Saparov. « Acceleration of Skin Wound-Healing Reactions by Autologous Micrograft Tissue Suspension ». Medicina 56, n^o 7 (29 juin 2020) : 321. http://dx.doi.org/10.3390/medicina56070321.

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Background and objectives: Skin grafting is a method usually used in reconstructive surgery to accelerate skin regeneration. This method results frequently in unexpected scar formations. We previously showed that cutaneous wound-healing in normal mice is accelerated by a micrograft (MG) technique. Presently, clinical trials have been performed utilizing this technology; however, the driving mechanisms behind the beneficial effects of this approach remain unclear. In the present study, we focused on five major tissue reactions in wound-healing, namely, regeneration, migration, granulation, neovascularization and contraction. Methods: Morphometrical analysis was performed using tissue samples from the dorsal wounds of mice. Granulation tissue formation, neovascularization and epithelial healing were examined. Results: The wound area correlated well with granulation sizes and neovascularization densities in the granulation tissue. Vascular distribution analysis in the granulation tissue indicated that neovessels extended and reached the subepidermal area in the MG group but was only halfway developed in the control group. Moreover, epithelialization with regeneration and migration was augmented by MG. Myofibroblast is a known machinery for wound contraction that uses α-smooth muscle actin filaments. Their distribution in the granulation tissue was primarily found beneath the regenerated epithelium and was significantly progressed in the MG group. Conclusions: These findings indicated that MG accelerated a series of wound-healing reactions and could be useful for treating intractable wounds in clinical situations.

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Komelyagina, Elena Yur'evna, Eugenia Alexandrovna Kogan et Mikhail Borisovich Antsiferov. « Clinical and morphological characteristics of wound healing in diabetic foot syndrome ». Diabetes mellitus 20, n^o 2 (20 juin 2017) : 135–41. http://dx.doi.org/10.14341/7704.

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Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn) Materials and Methods.Forty-three specimens of DFUn were analysed. Depending on the outcome, samples were divided into 2 groups: group 1healed ulcers (30 samples), group 2unhealed ulcers (13 samples). The following characteristics were analysed: age, sex, glycated haemoglobin (HbA1c), ulcer duration, time of admission to the specialised clinic, severity of neuropathy, presence of late complications, plantar localisation, percentage of necrotic tissue, granulation and fibrotic tissue and, Ki-67expression. Results. Patients were similar in age, HbA1c, severity of late complications and plantar localisation. There was a significant difference in the time of admission to the specialised clinic [50 vs 132 days, p = 0.03], percentage of granulation [61 25 vs 32 21 %, р = 0.001] and fibrotic tissue [24 24 vs 49 22 %, р = 0.002], the granulation/fibrosis coefficient [7.5 8.1 vs 1.9 4.6 (%), р = 0,02] and expression of Ki-67 [15 8 vs 21 (%), р = 0.001] between groups. A multidimensional model revealed granulation tissue as the main parameter influencing healing. The probability of healing was 1.0 if the percentage of granulation tissue was 50%. If the percentage of granulation tissue was 50%, the prognosis of healing was determined by the expression of Ki-67. When Ki-67 levels were 7%, the probability of healing was 0.75. For Ki-67 levels 7%, the probability of healing was 0.17 and the probability of not healing was 0.83. Conclusion. The time at which a patient was admitted to the specialised clinic and the percentage of granulation tissue were key factors affecting the prognosis of wound healing in DFUn.

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Tan, Naiwen, Maja Sabalic, Linh Nguyen et Francesco D’Aiuto. « Regenerative Potential of Granulation Tissue in Periodontitis : A Systematic Review and Meta-analysis ». Stem Cells International 2023 (7 mars 2023) : 1–11. http://dx.doi.org/10.1155/2023/8789852.

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Background and Aim. Soft and hard periodontal tissues contain limited numbers of stem cells. This makes regeneration of the periodontium in patients with periodontitis challenging and unpredictable. Granulation tissue is traditionally removed during periodontal corrective therapy, but it is believed to contain multipotent stem cells which could be used for regenerative therapy. The aim of this research was to critically appraise the evidence on cellular components within granulation tissue in patients with periodontitis and its regenerative potential when compared to control healthy periodontal tissue. Methods. Electronic searches were conducted in five databases including CENTRAL, MEDLINE, EMBASE, Web of Science, and Dentistry & Oral Sciences Source using a combination of MeSH terms and keywords up to 21 June 2022. Human studies including patients aged over 18 years with all forms of periodontitis were included. Following the risk of bias assessment, both qualitative and quantitative analyses were performed. Results. A total of twelve studies were included in qualitative analysis and six of them in quantitative analyses. The evidence suggested that cells derived from periodontitis granulation tissue have osteogenic, adipogenic, chondrogenic, neurogenic, and angiogenic differentiation abilities as well as immunoregulatory properties. In particular, CD44+, CD73+, CD90+, CD105+, and CD146+ cells were found widely in granulation tissue whilst the only meta-analysis confirmed that CD90+ cells were present in lower numbers within the granulation tissue when compared with healthy periodontal tissue ( WMD = − 23.43 % , 95% CI -30.43 to -16.44, p < 0.00001 ). Conclusions. This review provided further evidence that granulation tissue from patients with periodontitis can be a potential stem cell source for regenerative therapy.

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Parmar, Dr Kirit D., Dr Pratik H. Vyas, Dr Yajurvendra Gohil, Dr Jaydeep A. Maheshwari, Dr Dharmik B. Gondalia et Dr Bhargav M. Vasiyani. « A Study of Vacuum Assisted Closure Dressing in 50 Cases of Patients of Diabetic Limb ». BJKines National Journal of Basic & ; Applied Sciences 14, n^o 1 (10 juin 2022) : 53–57. http://dx.doi.org/10.56018/bjkines2022068.

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Background: To evaluate the effectiveness of VAC dressing for the management of diabetic limb. Material and Method: The study is a prospective comparative study which was conducted on 50 patients of diabetic limb ulcers admitted in General Surgery Department at Tertiary care hospital between June 2017 to June 2019. Patients were followed up until discharged from the hospital or completion of 8 weeks assessment period from the date of admission whichever was earlier. Result: Ulcer due to diabetes is common in males. 4% of the patients had hba1c level between 6.5 to 9.5. In 64% of patients granulation tissue appeared at the end of 2 weeks after VAC dressing while in only 40% of patients granulation tissue appeared after 2 weeks of conventional dressing. In 80% of patients wound was completely covered by granulation tissue at the end of 4 weeks after VAC dressing while only in 52% wound was completely covered by granulation tissue after 4 weeks of conventional dressing. Conclusion: VAC therapy is better than conventional therapies in terms of wound healing, less complications, reducing the hospital stay, reducing the bacterial infection load and is cost effective. Keywords: - VAC Therapy, diabetes, granulation tissue

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Steenfos, H. H., et J. O. Jansson. « Growth hormone stimulates granulation tissue formation and insulin-like growth factor-I gene expression in wound chambers in the rat ». Journal of Endocrinology 132, n^o 2 (février 1992) : 293–98. http://dx.doi.org/10.1677/joe.0.1320293.

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ABSTRACT It has been reported that GH stimulates fibroblast growth and wound healing. In the present study we measured the effect of locally applied GH on insulin-like growth factor (IGF-I) mRNA concentrations and granulation tissue formation in wound cylinders, implanted s.c. Four stainless-steel wiremesh cylinders were implanted s.c. in the back of male rats (280 g). Each cylinder was then injected every day with either 0·014 or 0·14 U human GH, or vehicle only. Ingrown granulation tissue and wound fluid was obtained on day 17 after implantation. The wet weight of granulation tissue was determined and concentrations of IGF-I mRNA in the tissue were measured by solution hybridization/RNAase protection assay. Similar assays were used to measure the levels of IGF-I receptor mRNA and GH receptor mRNA, while the IGF-I concentration in wound fluid and serum was determined by radioimmunoassay (RIA) after acid–ethanol extraction. The concentrations of IGF-I mRNA in ingrown granulation tissue as well as the wet weight of this tissue were significantly higher in the GH-treated cylinders. There was no significant effect of GH on IGF-I receptor mRNA and GH receptor mRNA levels. Consistent with the results of previous studies, wound fluid IGF-I levels were lower than serum IGF-I levels, but no significant difference was found between the GH-treated cylinders and the control cylinders. The results of the present study show that GH stimulates granulation tissue formation and increases the concentration of IGF-I mRNA in the ingrown granulation tissue. Journal of Endocrinology (1992) 132, 293–298

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Fortuna, Fory, Nandita Melati Putri et Gentur Sudjatmiko. « Granulation Red Index To Assess Pressure Ulcer Granulation Tissue Quality Treated By Honey Gauze Dressing By Digital Image Analysis ». Jurnal Plastik Rekonstruksi 6, n^o 2 (20 février 2020) : 270–75. http://dx.doi.org/10.14228/jpr.v6i2.284.

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Background : Good formation of granulation tissue in the ulcer bed is regarded as one of the indicators of pressure ulcer healing. Granulation red index (GRI) had been published as an objective parameter to assess the quality of granulation tissue. Honey stimulates granulation of tissue and creates a moist healing environment. However, the assessment of granulation tissue quality of pressure ulcers treated by honey has yet to be proven in clinical settings. In this study, we evaluate the granulation tissue quality of pressure ulcers treated by honey using granulation red index by digital image analyses. Method: There were 12 subjects who fulfill inclusion criteria treated by honey gauze dressing and were evaluated every week for three times measurements of %GRI and DESIGN-‐score. Parameters of this study were the delta %GRI80 and DESIGN-‐R score. Correlations were evaluated by Spearman’s correlation coefficient. Result : The correlation of delta GRI80% and DESIGN-‐R score was statistically significant from baseline measurement to first week of treatment and to second week of treatment (r1=0.65, p1=0.02 and r3=0.832, p2=0.001). The correlation of delta GRI80% and DESIGN-‐R score from first to second week therapy was not statistically significant (r=0.23, p=0.47), but the GRI80% from first week therapy to second week of therapy was increasing and DESIGN R score was decreasing. Conclusion:This study shows the correlation of %GRI80 and DESIGN-‐R score of pressure ulcer after the treatment of honey gauze dressing. This study hopefully assists further study for wound bed preparation assessment and treatment of pressure ulcer for surgical intervention.

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Aprile, I., S. Pizzolitto, F. De Nardi, P. Del Fabro, F. Iaiza, B. Petralia, G. Fabris et M. Leonardi. « Correlazione RM-istopatologica del potenziamento periferico delle ernie discali ». Rivista di Neuroradiologia 10, n^o 2_suppl (octobre 1997) : 213–14. http://dx.doi.org/10.1177/19714009970100s295.

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We found ring enhancement in 10 patients with lumbar disc herniation examined with magnetic resonance. In 5 cases histological examination showed peri-discal granulation tissue. The peripheral enhancement found in some cases of disc herniation is caused by inflammatory granulation tissue.

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Ahmad, Samera, Daniel Capiz-Correa et Hans E. Grossniklaus. « Pyogenic Granuloma of the Retina : A Case Series ». Ocular Oncology and Pathology 5, n^o 3 (10 septembre 2018) : 176–81. http://dx.doi.org/10.1159/000492598.

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Aim: To describe the clinicopathologic features of pyogenic granuloma (granulation tissue proliferation) extending from the retina. Methods: We describe 3 patients who underwent enucleation for endophthalmitis. The eyes were processed routinely for histopathologic examination. Results: All 3 enucleated eyes contained granulation tissue with reactive vascular channels and intervening stroma infiltrated with inflammatory cells. The vascular channels were arranged in a fan-like configuration and the tissue was classified as representing pyogenic granulomas. Conclusions: Pyogenic granulomas (granulation tissue) may emanate from the retina in cases of endophthalmitis. This is distinct from neovascularization that may occur in proliferative diabetic retinopathy, central retinal vein occlusion, or other etiologies.

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Krishnaprasad, I. N., V. Soumya et S. Abdulgafoor. « Management of Over-Granulation in a Diabetic Foot Ulcer : A Clinical Experience ». Indian Journal of Physical Medicine and Rehabilitation 24, n^o 1 (2013) : 19–22. http://dx.doi.org/10.5005/ijopmr-24-1-19.

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Abstract Over-granulation or exuberant granulation tissue is a common problem encountered in the care of chronic wounds, especially that of diabetic foot ulcers. There are several potential options for the treatment of this challenging problem. Some have an immediate short term effect but may have a longer term unfavourable effect, for example, silver nitrate application and surgical excision, which may delay wound healing by reverting the wound back to the inflammatory phase of healing. Other products, such as foams and silver dressings may offer some effect in short term, but their long term effects are questionable. The more recent research supports Haelan cream and tape as an efficacious and cost effective treatment for over-granulation in a variety of wound types. The future of treating over-granulation may lie with surgical lasers, since lasers can not only remove over-granulation tissue but will also cauterise small blood vessels and are very selective, leaving healing cells alone while removing excess and unhealthy tissue. Recently Drs Lain and Carrington have demonstrated the utility of imiquimod, an immune-modulator with anti-angiogenic properties, in the treatment exuberant granulation tissue, in a patient with long standing diabetic foot ulcer, resistant to other forms of therapy. We adapted a modified version of their protocol in the management of a similar patient in our hospital and achieved a good result in lesser time than the former.

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Shrestha, D., P. Thapa et YB Bhandari. « Types of pathology and ossicular status in atticoantral disease undergoing mastoidectomy at Bir Hospital ». Journal of College of Medical Sciences-Nepal 6, n^o 4 (30 août 2012) : 26–30. http://dx.doi.org/10.3126/jcmsn.v6i4.6722.

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A prospective study was carried out in the department of ENT and Head and Neck Surgery in Bir Hospital, Kathmandu to know the types of the pathology and the ossicular status in atticoantral disease. This study included 100 cases of CSOM (AA) scheduled for routine mastoidectomy. In this study cholesteotoma was the commonest pathology 61 (61%) followed by granulation tissue alone in 27 (27%) cases and both cholesteotoma and granulation tissue were found in 12 (12%) cases. Ossicular damage was more common in CSOM (AA) with granulation tissue in all 27 (100%), 54(58.06%) in CSOM(AA) with cholesteotoma and 12 (12.9%) in CSOM(AA) with both cholesteotoma and granulation tissue. M+S+ ossicular defect was the commonest ossicular defect 47 (50.53%) followed by M+S-24(25.80%), M-S+13(13.97%)and M-S- 9(9.67%) cases.Journal of College of Medical Sciences-Nepal,2011,Vol-6,No-4, 26-30 DOI: http://dx.doi.org/10.3126/jcmsn.v6i4.6722

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