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Littérature scientifique sur le sujet « Transcriptional co-aActivator with PDZ-Binding motif (TAZ) »

Auteur : Grafiati
Publié le 5 avril 2025

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Articles de revues sur le sujet "Transcriptional co-aActivator with PDZ-Binding motif (TAZ)"

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Wu, Chia-Lin, Chia-Chu Chang, Tao-Hsiang Yang, et al. "Tubular transcriptional co-activator with PDZ-binding motif protects against ischemic acute kidney injury." Clinical Science 134, no. 13 (2020): 1593–612. http://dx.doi.org/10.1042/cs20200223.

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Abstract Transcriptional co-activator with PDZ-binding motif (TAZ) is a key downstream effector of the Hippo tumor-suppressor pathway. The functions of TAZ in the kidney, especially in tubular epithelial cells, are not well-known. To elucidate the adaptive expression, protective effects on kidney injury, and signaling pathways of TAZ in response to acute kidney injury (AKI), we used in vitro (hypoxia-treated human renal proximal tubular epithelial cells [RPTECs]) and in vivo (mouse ischemia–reperfusion injury [IRI]) models of ischemic AKI. After ischemic AKI, TAZ was up-regulated in RPTECs and
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Huang, Yao, Xueqian Ouyang, Jinghua Tan, Zhenyu Meng, Xiuwen Ma, and Yiguo Yan. "The physiological and pathogenic roles of yes-associated protein/transcriptional co-activator with PDZ-binding motif in bone or skeletal motor system-related cells." Cytojournal 22 (February 8, 2025): 13. https://doi.org/10.25259/cytojournal_237_2024.

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Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the primary downstream effectors of the Hippo signaling pathway. This pathway plays a crucial role in regulating organ size, maintaining tissue homeostasis, and controlling cellular processes such as fate determination and tissue development. This review provides an overview of the current understanding of how the transcriptional regulators YAP and TAZ contribute to the physiological and pathological processes in tissues and cells associated with the skeletal motor system. The underlying molecular me
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Zhang, Jinglin, Yuhang Zhou, Patrick Tang, et al. "Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis." International Journal of Molecular Sciences 20, no. 7 (2019): 1576. http://dx.doi.org/10.3390/ijms20071576.

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The essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain transcription regulator 1 (TAZ), two transcriptional co-activators with a PDZ-binding motif, function as critical effectors negatively regulated by the Hippo pathway. Previous studies indicate the involvement of YAP1/TAZ in mechanotransduction by crosstalking with the extracellul
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Liu, Tao, Jiaojiao Zhou, Yanmin Chen, et al. "Genome-Wide Characterization of TAZ Binding Sites in Mammary Epithelial Cells." Cancers 15, no. 19 (2023): 4713. http://dx.doi.org/10.3390/cancers15194713.

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The transcriptional co-activator with PDZ binding motif (TAZ) is a key effector of the Hippo signaling pathway. We and others previously reported that high expression levels of TAZ are positively associated with decreased survival rates and shorter times to relapse in basal-like breast cancer (BLBC) patients. The oncogenic activity of TAZ involves the regulation of diverse signal transduction pathways that direct processes such as cell proliferation, migration, and resistance to apoptosis, albeit through poorly characterized gene expression programs. Here, using a tet-inducible system in mamma
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Tóth, Marcell, Shan Wan, Jennifer Schmitt, et al. "The Cell Polarity Protein MPP5/PALS1 Controls the Subcellular Localization of the Oncogenes YAP and TAZ in Liver Cancer." International Journal of Molecular Sciences 26, no. 2 (2025): 660. https://doi.org/10.3390/ijms26020660.

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The oncogenes yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are potent liver oncogenes. Because gene mutations cannot fully explain their nuclear enrichment, we aim to understand which mechanisms cause YAP/TAZ activation in liver cancer cells. The combination of proteomics and functional screening identified numerous apical cell polarity complex proteins interacting with YAP and TAZ. Co-immunoprecipitation (Co-IP) experiments confirmed that membrane protein palmitoylated 5 (MPP5; synonym: PALS1) physically interacts with YAP and TAZ. After removing d
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Tiffon, Camille, Julie Giraud, Silvia Elena Molina-Castro, et al. "TAZ Controls Helicobacter pylori-Induced Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties." Cells 9, no. 6 (2020): 1462. http://dx.doi.org/10.3390/cells9061462.

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Helicobacter pylori infection, the main risk factor for gastric cancer (GC), leads to an epithelial–mesenchymal transition (EMT) of gastric epithelium contributing to gastric cancer stem cell (CSC) emergence. The Hippo pathway effectors yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) control cancer initiation and progression in many cancers including GC. Here, we investigated the role of TAZ in the early steps of H. pylori-mediated gastric carcinogenesis. TAZ implication in EMT, invasion, and CSC-related tumorigenic properties were evaluated in three
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Salem and Hansen. "The Hippo Pathway in Prostate Cancer." Cells 8, no. 4 (2019): 370. http://dx.doi.org/10.3390/cells8040370.

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Despite recent efforts, prostate cancer (PCa) remains one of the most common cancers in men. Currently, there is no effective treatment for castration-resistant prostate cancer (CRPC). There is, therefore, an urgent need to identify new therapeutic targets. The Hippo pathway and its downstream effectors—the transcriptional co-activators, Yes-associated protein (YAP) and its paralog, transcriptional co-activator with PDZ-binding motif (TAZ)—are foremost regulators of stem cells and cancer biology. Defective Hippo pathway signaling and YAP/TAZ hyperactivation are common across various cancers. H
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Miyajima, Chiharu, Yurika Hayakawa, Yasumichi Inoue, Mai Nagasaka, and Hidetoshi Hayashi. "HMG-CoA Reductase Inhibitor Statins Activate the Transcriptional Activity of p53 by Regulating the Expression of TAZ." Pharmaceuticals 15, no. 8 (2022): 1015. http://dx.doi.org/10.3390/ph15081015.

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Transcriptional coactivator with PDZ-binding motif (TAZ) is a downstream transcriptional regulator of the Hippo pathway that controls cell growth and differentiation. The aberrant activation of TAZ correlates with a poor prognosis in human cancers, such as breast and colon cancers. We previously demonstrated that TAZ inhibited the tumor suppressor functions of p53 and enhanced cell proliferation. Statins, which are used to treat dyslipidemia, have been reported to suppress the activity of TAZ and exert anti-tumor effects. In the present study, we focused on the regulation of p53 functions by T
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Warren, Janine, Yuxuan Xiao, and John Lamar. "YAP/TAZ Activation as a Target for Treating Metastatic Cancer." Cancers 10, no. 4 (2018): 115. http://dx.doi.org/10.3390/cancers10040115.

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Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ) have both emerged as important drivers of cancer progression and metastasis. YAP and TAZ are often upregulated or nuclear localized in aggressive human cancers. There is abundant experimental evidence demonstrating that YAP or TAZ activation promotes cancer formation, tumor progression, and metastasis. In this review we summarize the evidence linking YAP/TAZ activation to metastasis, and discuss the roles of YAP and TAZ during each step of the metastatic cascade. Collectively, this evidence strongly sugg
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Chu, Cong-Qiu, and Taihao Quan. "Fibroblast Yap/Taz Signaling in Extracellular Matrix Homeostasis and Tissue Fibrosis." Journal of Clinical Medicine 13, no. 12 (2024): 3358. http://dx.doi.org/10.3390/jcm13123358.

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Tissue fibrosis represents a complex pathological condition characterized by the excessive accumulation of collagenous extracellular matrix (ECM) components, resulting in impaired organ function. Fibroblasts are central to the fibrotic process and crucially involved in producing and depositing collagen-rich ECM. Apart from their primary function in ECM synthesis, fibroblasts engage in diverse activities such as inflammation and shaping the tissue microenvironment, which significantly influence cellular and tissue functions. This review explores the role of Yes-associated protein (Yap) and Tran
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Thèses sur le sujet "Transcriptional co-aActivator with PDZ-Binding motif (TAZ)"

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Hughes, Lucinda Jane. "Yes-Associated Protein (YAP) and Transcriptional Co-Activator with PDZ Binding Motif (TAZ) Function in Normal Cerebellar Development and Medulloblastoma." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/412035.

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Biomedical Sciences<br>Ph.D.<br>The Hippo signaling pathway was first discovered in Drosophila melanogaster and is involved in organ size control by regulating cell proliferation and apoptosis. This well conserved pathway is activated by various signal inputs, including cell-cell contact, mechanotransduction, and G-protein coupled receptors, with signals converging on the downstream effector protein Yap and its homologue Taz, which are transcriptional co-activators. When the Hippo pathway is activated, Yap/Taz are phosphorylated, leading to cytoplasmic retention and degradation, and diminishin
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Ruscica, Biagina. "The critical role of YAP and TAZ in tubular homeostasis." Electronic Thesis or Diss., Université Paris Cité, 2024. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=6623&f=77103.

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Des études épidémiologiques et expérimentales suggèrent que la progression de la maladie rénale chronique (MRC) après une lésion initiale est génétiquement déterminée, mais les réseaux génétiques qui contribuent à cette prédisposition restent inconnus. Parmi les voies moléculaires potentielles impliquées dans la MRC, cette étude s'est concentrée sur la voie Hippo, une cascade de signalisation conservée au cours de l'évolution et cruciale pour la régulation de la taille des organes et de la prolifération cellulaire. Les protéines paralogues YAP et TAZ, deux coactivateurs transcriptionnels de la
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