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1

Wang, Qian, Yanli Shao, and Ming Lu. "Amino-tetrazole functionalized fused triazolo-triazine and tetrazolo-triazine energetic materials." Chemical Communications 55, no. 43 (2019): 6062–65. http://dx.doi.org/10.1039/c9cc01777a.

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In this study, two insensitive energetic compounds using fused triazolo-triazine and tetrazolo-triazine as the framework, one amino and one tetrazole as functional groups, were prepared through a two-step reaction.
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Pathak, Suraj Kumar, Yepeng Xiang, Manli Huang, et al. "Fused tetracyclic tris[1,2,4]triazolo[1,3,5]triazine as a novel rigid electron acceptor for efficient thermally activated delayed fluorescence emitters." RSC Advances 10, no. 26 (2020): 15523–29. http://dx.doi.org/10.1039/d0ra01925a.

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Zeng, Qun, Yanyang Qu, Jinshan Li, and Hui Huang. "Theoretical studies on the derivatives of tris([1,2,4]triazolo)[4,3-a:4′,3′-c:4′′,3′′-e][1,3,5]triazine as high energetic compounds." RSC Advances 6, no. 7 (2016): 5419–27. http://dx.doi.org/10.1039/c5ra22524h.

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Navarro, Amparo, M. Paz Fernández-Liencres, Gregorio García, José M. Granadino-Roldán та Manuel Fernández-Gómez. "A DFT approach to the charge transport related properties in columnar stacked π-conjugated N-heterocycle cores including electron donor and acceptor units". Physical Chemistry Chemical Physics 17, № 1 (2015): 605–18. http://dx.doi.org/10.1039/c4cp04220d.

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Bernat, Zofia, Anna Szymanowska, Mateusz Kciuk, Katarzyna Kotwica-Mojzych, and Mariusz Mojzych. "Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives." Molecules 25, no. 17 (2020): 3948. http://dx.doi.org/10.3390/molecules25173948.

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This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.
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Hojo, Ryoga, Don M. Mayder, and Zachary M. Hudson. "Donor–acceptor materials exhibiting deep blue emission and thermally activated delayed fluorescence with tris(triazolo)triazine." Journal of Materials Chemistry C 9, no. 40 (2021): 14342–50. http://dx.doi.org/10.1039/d1tc03480d.

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Five emitters with the tris(triazolo)triazine acceptor core are reported, with emission from deep blue to green. These emitters show promising thermally activated delayed fluorescence and/or two-photon fluorescence properties.
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Hojo, Ryoga, Don M. Mayder, and Zachary M. Hudson. "Donor–acceptor materials exhibiting deep blue emission and thermally activated delayed fluorescence with tris(triazolo)triazine." Journal of Materials Chemistry C 9, no. 40 (2021): 14342–50. http://dx.doi.org/10.1039/d1tc03480d.

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Five emitters with the tris(triazolo)triazine acceptor core are reported, with emission from deep blue to green. These emitters show promising thermally activated delayed fluorescence and/or two-photon fluorescence properties.
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Hundemer, Fabian, Ettore Crovini, Yoshimasa Wada, Hironori Kaji, Stefan Bräse, and Eli Zysman-Colman. "Tris(triazolo)triazine-based emitters for solution-processed blue thermally activated delayed fluorescence organic light-emitting diodes." Materials Advances 1, no. 8 (2020): 2862–71. http://dx.doi.org/10.1039/d0ma00659a.

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We report a new emitter 3,4,5-3TCz-TTT based on a tris(triazolo)triazine acceptor that shows thermally activated delayed fluorescence and cross-compare its performance with the recently reported analogue, 3DMAC-TTT.
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9

Fang, Zhou, Shengyue Wang, Junxu Liao, et al. "Asymmetric sky-blue thermally-activated delayed fluorescence emitters bearing tris(triazolo)triazine moiety for solution-processable organic light-emitting diodes." Journal of Materials Chemistry C 10, no. 12 (2022): 4837–44. http://dx.doi.org/10.1039/d1tc05372h.

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Two sky-blue TADF emitters bearing the tris(triazolo)triazine acceptor moiety were designed and synthesized. The solution-processed OLEDs based on these two emitters achieved a maximum EQE of 10.01% at 474 nm.
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Anikin, Oleg V., Nikita E. Leonov, Michael S. Klenov, et al. "An Energetic (Nitro-NNO -azoxy)triazolo-1,2,4-triazine." European Journal of Organic Chemistry 2019, no. 26 (2019): 4189–95. http://dx.doi.org/10.1002/ejoc.201900314.

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Molina, Pedro, Mateo Alajar地, Ma Jes徭 P屍ez de Vega, and Antonio L用ez. "Preparation of [1,2,4]Triazolo[5,1-c][1,2,4]triazine Derivatives from 3,4-Diamino[1,2,4]triazine." HETEROCYCLES 29, no. 8 (1989): 1607. http://dx.doi.org/10.3987/com-89-5056.

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Piercey, Davin G., David E. Chavez, Brian L. Scott, Greg H. Imler, and Damon A. Parrish. "An Energetic Triazolo-1,2,4-Triazine and its N-Oxide." Angewandte Chemie International Edition 55, no. 49 (2016): 15315–18. http://dx.doi.org/10.1002/anie.201608723.

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Piercey, Davin G., David E. Chavez, Brian L. Scott, Greg H. Imler, and Damon A. Parrish. "An Energetic Triazolo-1,2,4-Triazine and its N-Oxide." Angewandte Chemie 128, no. 49 (2016): 15541–44. http://dx.doi.org/10.1002/ange.201608723.

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Abdel-Rahman, Reda M., Abdulrahman S. Alharbi, Nawaa A. Alshammari, and Yousuf O. Adnan. "Design, Synthesis and Molluscicidal Activity of New Phosphorus Compounds Bearing Fluorine Substituted 1,2,4-Triazolo[3,2-c][1,2,4]triazine Derivatives." Letters in Organic Chemistry 17, no. 3 (2020): 184–90. http://dx.doi.org/10.2174/1570178616666190718120953.

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Novel phosphorus compounds bearing fluorine substituted 1,2,4-triazolo[3,2-c][1,2,4]triazine derivatives have been synthesized, starting from ring closure reactions of 3-hydrazino-4-(4`- fluorophenyl)-5-(prydin-4`-yl)-1,2,4-trizole (4) with 1,2-bioxygen compounds followed by the treatment with functional phosphorus compounds. The new systems obtained were evaluated as molluscicidal targets against some snails. Structures of these targets were elucidated upon their elemental and spectral data.
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Heravi, Majid M., Naser Montazeri, Mohammad Rahimizadeh, Mehdi Bakavoli, and Mitra Ghassemzadeh. "Synthesis of 1,2,4-triazolo[1,5-d]-1,2,4-triazine-5-thiones." Journal of Heterocyclic Chemistry 42, no. 5 (2005): 1021–25. http://dx.doi.org/10.1002/jhet.5570420544.

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Kumar, Dheeraj, Gregory H. Imler, Damon A. Parrish, and Jean'ne M. Shreeve. "A Highly Stable and Insensitive Fused Triazolo-Triazine Explosive (TTX)." Chemistry - A European Journal 23, no. 8 (2016): 1743–47. http://dx.doi.org/10.1002/chem.201604919.

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Epishina, Margarita A., Alexander S. Kulikov, and Leonid L. Fershtat. "Revisiting the Synthesis of Functionally Substituted 1,4-Dihydrobenzo[e][1,2,4]triazines." Molecules 27, no. 8 (2022): 2575. http://dx.doi.org/10.3390/molecules27082575.

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A series of novel 1,4-dihydrobenzo[1,2,4][e]triazines bearing an acetyl or ester moiety as a functional group at the C(3) atom of the 1,2,4-triazine ring were synthesized. The synthetic protocol is based on an oxidative cyclization of functionally substituted amidrazones in the presence of DBU and Pd/C. It was found that the developed approach is suitable for the preparation of 1,4-dihydrobenzo[e][1,2,4]triazines, but the corresponding Blatter radicals were isolated only in few cases. In addition, a previously unknown dihydrobenzo[e][1,2,4]triazolo[3,4-c][1,2,4]triazine tricyclic open-shell de
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18

Bianchi, Mario, Alina Butti, and Jacques Perronnet. "A new heterocyclic structure. The [1,2,3]triazolo[1,5-d][1,2,4]triazine." Journal of Heterocyclic Chemistry 25, no. 3 (1988): 743–50. http://dx.doi.org/10.1002/jhet.5570250309.

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Fahim, Asmaa, Ahmad Farag, Mohamed Shaaban, and Eman Ragab. "Microwave Assisted Synthesis of Pyrazolo[1,5-a]pyrimidine, Triazolo[1,5-a]pyrimidine, Pyrimido[1,2-a]benzimdazole, Triazolo[5,1-c][1,2,4]triazine and Imidazo[2,1-c][1,2,4]triazine." Current Microwave Chemistry 5, no. 2 (2019): 111–19. http://dx.doi.org/10.2174/2213335605666180425144009.

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Akahoshi, Fumihiko, Shinji Takeda, Takehiro Okada, et al. "Synthesis and Pharmacological Activity of Triazolo[1,5-a]triazine Derivatives Inhibiting Eosinophilia." Journal of Medicinal Chemistry 41, no. 16 (1998): 2985–93. http://dx.doi.org/10.1021/jm970759u.

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Mironovich, L. M., M. A. Ivanov, and E. P. Koval'chuk. "ChemInform Abstract: Synthesis of 8-tert-Butyl-9-oxo-1,2,4-triazolo[4,5-b]-1,2,4-triazolo [3,4-c]-1,2,4-triazine." ChemInform 33, no. 32 (2010): no. http://dx.doi.org/10.1002/chin.200232154.

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El-Shehry, M. F., F. A. A. El-Hag, and E. F. Ewies. "Synthesis and Antimicrobial Study of New Fused Thiazolo[3,2-b]triazine, Triazolo[4,3-b]triazine, and 1,2,4-Triazinone Derivatives." Russian Journal of Organic Chemistry 56, no. 1 (2020): 129–36. http://dx.doi.org/10.1134/s1070428020010200.

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Fedotov, S. O., and A. S. Hotsulia. "Synthesis and properties of 3-(ethylthio)-9-methyl-6-(alkylthio)pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines." Current issues in pharmacy and medicine: science and practice 15, no. 3 (2022): 227–34. http://dx.doi.org/10.14739/2409-2932.2022.3.263994.

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The combination of pyrazole and 1,2,4-triazole fragments in one structure makes it possible to achieve some success in creating potential biologically active compounds. Various factors contribute to this process. Among them, we can note the significant possibilities of chemical transformation involving these cycles, the simplicity, and reliability of methods, the creation of molecules with a certain level of bioavailability and the ability to influence a number of biochemical processes. Taking into account the presented facts, the creation of new compounds in a number of pyrazolo-triazole cond
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Ezema, B. E., L. E. S. Akpanisi, C. G. Ezema, and A. E. Onoabedje. "A New Method of Dimroth Rearrangement in Fused Triazolo[1,5-d]-1,2,4-triazine." Journal of Heterocyclic Chemistry 52, no. 5 (2014): 1411–14. http://dx.doi.org/10.1002/jhet.2252.

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Kurella, M. G., L. G. Vorontsova, A. R. Amamchyan, and V. A. Dorokhov. "Crystal and molecular structure of 7-phenyl-1,2,4-triazolo[1,5-a]-1,3,5-triazine." Bulletin of the Russian Academy of Sciences Division of Chemical Science 41, no. 6 (1992): 1084–86. http://dx.doi.org/10.1007/bf00866591.

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Khalil, Mohamed A., Samia M. Sayed, and Mohamed A. Raslan. "Synthesis of New Pyrazolo[5,1-c]triazine, Triazolo[5,1-c]triazine, Triazino[4,3-b]indazole and Benzimidazo[2,1-c]triazine Derivatives Incorporating Chromen-2-one Moiety." Journal of the Korean Chemical Society 57, no. 5 (2013): 612–17. http://dx.doi.org/10.5012/jkcs.2013.57.5.612.

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27

Deeb, Ali, Medhat El-Mobayed, Abdel Naby Essawy, Adel Abd El-Hamid, and Atef Mohamid Abd El-Hamid. "Heterocyclic synthesis from 3-amino-4-cyanopyrazole." Collection of Czechoslovak Chemical Communications 55, no. 3 (1990): 728–33. http://dx.doi.org/10.1135/cccc19900728.

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3-Amino-4-cyanopyrazole I reacts with hydroxylamine and with hydrazine to yield 1H,6H-3-aminopyrazolo[3,4-c]pyrazole (III and IV). Diazotized IV couples with 2-naphthol to give the arylazo derivative VI which cyclizes to 9H-naphthol[2,1-e]pyrazolo[3',4':3,4]pyrazolo[5,1-c]-[1,2,4]triazine VII by means of acetic acid. The pyrazol-5-ylthiourea obtained from I and phenyl isothiocyanate undergoes base-catalyzed cyclization to give pyrazolo[3,4-d]pyrimidinethione derivative IX. Compound I reacts with cyclohexane in the presence of zinc chloride to give the tetrahydropyrazolo[3,4-b]quinoline derivat
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Krutošíková, Alžbeta, Slavomír Mastik, Miloslava Dandárová, and Antonín Lyčka. "Synthesis and Reactions of 8-Hydrazinofuro[2',3':4,5]pyrrolo-[1,2-d][1,2,4]triazines." Collection of Czechoslovak Chemical Communications 62, no. 10 (1997): 1612–22. http://dx.doi.org/10.1135/cccc19971612.

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5-Ethyl-8-hydrazinofuro[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine (4a) and its 2-methyl derivative 4b were prepared from 4H-furo[3,2-b]pyrrole-5-carbohydrazides 1a and 1b, respectively. Compounds 1a and 1b reacted with triethyl orthopropionate to give 2a and 2b which afforded with phosphorus(V) sulfide corresponding thiones 3a and 3b. The title compounds 4a and 4b were made by treatment of 3a and 3b with hydrazine hydrate. By reactions of triethyl orthoesters with the title compounds and similar derivatives furo[2'3':4,5]pyrrolo[1,2-d][1,2,4]triazolo[3,4-f][1,2,4]triazines 5a-5j were prepared. R
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Gomha, Sobhi, and Hatem Abdel-Aziz. "Synthesis of new functionalized derivatives of indolo[2,3-e][1,2,4]-triazolo-[4,5-b]-1,2,4-triazine." Journal of the Serbian Chemical Society 78, no. 8 (2013): 1119–25. http://dx.doi.org/10.2298/jsc120914013g.

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New functionalized 1,2,4-triazolo-[4,3-b]-1,2,4-triazino-[5,6-b]indole derivatives were synthesized via reaction of the hydrazonoyl halides with 5H-2,3-dihydro-1,2,4-triazino[5,6-b]indole-3-thione or its 3-methylthio derivative. The mechanism and the regioselectivity of the studied reactions have been discussed.
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NAITO, Y., and ET AL ET AL. "ChemInform Abstract: Synthesis and Pharmacological Activity of Triazolo[1,5-a]triazine Derivatives Inhibiting Eosinophilia." ChemInform 29, no. 48 (2010): no. http://dx.doi.org/10.1002/chin.199848167.

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Zhang, Guojie, Wei Hu, Jinchao Ma, Hongwei Yang, and Guangbin Cheng. "Combining 5,6-fused triazolo-triazine with pyrazole: A novel energetic framework for heat-resistant explosive." Chemical Engineering Journal 426 (December 2021): 131297. http://dx.doi.org/10.1016/j.cej.2021.131297.

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Qu, Yanyang. "Synthesis and Properties for Benzotriazole Nitrogen Oxides (BTzO) and Tris[1,2,4]triazolo[1,3,5]triazine Derivatives." International Journal of Materials Science and Applications 7, no. 2 (2018): 49. http://dx.doi.org/10.11648/j.ijmsa.20180702.13.

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Bera, Hriday, Anton V. Dolzhenko, Lingyi Sun, Sayan Dutta Gupta, and Wai-Keung Chui. "Synthesis andin vitroEvaluation of 1,2,4-Triazolo[1,5-a][1,3,5]triazine Derivatives as Thymidine Phosphorylase Inhibitors." Chemical Biology & Drug Design 82, no. 3 (2013): 351–60. http://dx.doi.org/10.1111/cbdd.12171.

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Abdelrehim, El-sayed M., and Doaa S. El-Sayed. "A New Synthesis of Poly Heterocyclic Compounds Containing [1,2,4]triazolo and [1,2,3,4]tetrazolo Moieties and their DFT Study as Expected Anti-cancer Reagents." Current Organic Synthesis 17, no. 3 (2020): 211–23. http://dx.doi.org/10.2174/1570179417666200226092516.

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Background: 2-amino-3-cyanopyridines are good starting reagents that have been used in synthesis of many heterocyclic compounds such as pyridopyrimidines, [1,2,4]triazolo and [1,2,3,4] tetrazolo derivatives which have biological activities as anti-microbial and cytotoxic activities. Meanwhile [1,2,4]triazolo and [1,2,3,4]tetrazolo derivatives are well known to possess many physiological activities, such as anticancer , antifungal, muscle relaxant, hypnotic, anti-inflammatory, diuretic and antihypertensive activities. A broad class of heterocyclic compounds has been studied to demonstrate their
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Zohdi, Hussein F. "Reactions with 3-Amino-5-trifluoromethyl[1,2,4]-triazole: A Convenient Route to Fluorinated Triazolo[1,5-c]thiadiazine, Triazolo[1,5-a]triazine, Thiazoles and Thiadiazoles." Journal of Chemical Research, no. 9 (1998): 536–37. http://dx.doi.org/10.1039/a802034e.

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El-Sayed, Wael A., Ibrahim F. Nassar, and Adel A. H. Abdel-Rahman. "Synthesis and antitumor activity of new 1,2,4-triazine and [1,2,4]triazolo[4,3-b][1,2,4]triazine derivatives and their thioglycoside and acyclic C-nucleoside analogs." Journal of Heterocyclic Chemistry 48, no. 1 (2010): 135–43. http://dx.doi.org/10.1002/jhet.522.

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Hajri, A., and L. Marzouki. "Easy Strategy for the Synthesis of New 5,6-Dihydro-[1,2,4]triazolo[4,3-a][1,3,5]triazine Derivatives." Russian Journal of Organic Chemistry 55, no. 9 (2019): 1394–98. http://dx.doi.org/10.1134/s1070428019090203.

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HAJRI, A., and L. MARZOUKI. "EASY STRATEGY FOR THE SYNTHESIS OF NEW 5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A][1,3,5]TRIAZINE DERIVATIVES." Журнал органической химии 55, no. 9 (2019): 1475. http://dx.doi.org/10.1134/s0514749219090222.

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Vu, Chi B., Bo Peng, Gnanasambandam Kumaravel, et al. "Piperazine Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2aReceptor Antagonists." Journal of Medicinal Chemistry 47, no. 17 (2004): 4291–99. http://dx.doi.org/10.1021/jm0498405.

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F. Zohdi, Hussein. "Reactions with 3-Amino-5-trifluoromethyl-1,2,4-triazole: a Simple Route to Fluorinated Poly-substituted Triazolo[1,5-a]pyrimidine and Triazolo[5,1-c]triazine Derivatives." Journal of Chemical Research, no. 11 (1997): 392. http://dx.doi.org/10.1039/a701093a.

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M. Farag, Ahmad, Mohamed R. Shaaban, and Tamer S. Saleh. "An Efficient Single Step Synthesis of Pyridazine, Pyrazolo[5,1-c]-1,2,4-triazine, 1,2,4-Triazolo[5,1-c]-1,2,4-triazine and 1,2,4-Triazino[4,3-a]benzimidazole Derivatives." HETEROCYCLES 78, no. 3 (2009): 699. http://dx.doi.org/10.3987/com-08-11559.

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Abdel-Aziz, Hatem A., Nehal A. Hamdy, Issa M. I. Fakhr, and Ahmad M. Farag. "Synthesis of some novel pyrazolo[1,5-a]pyrimidine, 1,2,4-triazolo[1,5-a]pyrimidine, pyrido[2,3-d]pyrimidine, pyrazolo[5,1-c]-1,2,4-triazine and 1,2,4-triazolo[5,1-c]-1,2,4-triazine derivatives incorporating a thiazolo[3,2-a]benzimidazole moiety." Journal of Heterocyclic Chemistry 45, no. 4 (2008): 1033–37. http://dx.doi.org/10.1002/jhet.5570450413.

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Kruglenko, V. P., V. P. Gnidets, and M. V. Povstyanoi. "Synthesis of 2-methyl-1,2,4-triazolo[4,3-d]-1,2,4-triazino[2,3-a]-benzimidazole and 2-methyl-9-phenylimidazo[1,2-b]-1,2,4-triazolo[4,3-d]-1,2,4-triazine." Chemistry of Heterocyclic Compounds 36, no. 1 (2000): 103–4. http://dx.doi.org/10.1007/bf02256854.

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Zohdi, Hussein F. "ChemInform Abstract: Reactions with 3-Amino-5-trifluoromethyl[1,2,4]triazole: A Convenient Route to Fluorinated Triazolo[1,5-c]thiadiazine, Triazolo[1,5-a]triazine, Thiazoles, and Thiadiazoles." ChemInform 30, no. 12 (2010): no. http://dx.doi.org/10.1002/chin.199912144.

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