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Articles de revues sur le sujet « Tumor Residual »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Kasbekar, Anand, Guleed Adan, Alaina Beacall, Ahmed Youssef, Catherine Gilkes, and Tristram Lesser. "Growth Patterns of Residual Tumor in Preoperatively Growing Vestibular Schwannomas." Journal of Neurological Surgery Part B: Skull Base 79, no. 04 (2017): 319–24. http://dx.doi.org/10.1055/s-0037-1607421.

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Objectives To analyze growth of residual vestibular schwannoma (VS) following incomplete tumor resection and determine the influence of residual location and size. Design Retrospective case note and scan review. Setting Tertiary skull base unit. Participants Patients with residual tumor following primary surgery for medium and large unilateral growing vestibular schwanomas between 2006 and 2009. Main Outcome Measures Location of residual VS and post-operative growth, comparing those with more (>5%) or less than 5% of tumor residual (<5%). Results Fifty-two patients had visible residual t

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Panni, Roheena Z., Ivan Gonzalez, Christopher P. Hartley, et al. "Residual Tumor Index." American Journal of Surgical Pathology 42, no. 11 (2018): 1480–87. http://dx.doi.org/10.1097/pas.0000000000001144.

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Wittekind, Christian, and Paul Hermanek. "Residual Tumor Classification." Advances in Anatomic Pathology 2, no. 4 (1995): 277–79. http://dx.doi.org/10.1097/00125480-199507000-00055.

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Kishida, Takeshi. "Postchemotherapy residual tumor." Annals of Oncology 28 (October 2017): ix52. http://dx.doi.org/10.1093/annonc/mdx627.001.

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Xu, Xiaohong, Liangping Luo, Jiexin Chen, et al. "Acoustic Radiation Force Impulse Elastography for Efficacy Evaluation after Hepatocellular Carcinoma Radiofrequency Ablation: A Comparative Study with Contrast-Enhanced Ultrasound." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/901642.

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Aim. To explore acoustic radiation force impulse (ARFI) elastography in assessing residual tumors of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA).Materials and Methods. There were 83 HCC lesions among 72 patients. All patients were examined with ARFI, contrast enhanced ultrasound (CEUS), and CT or MRI. Tumor brightness on virtual touch tissue imaging (VTI) and shear wave velocity (SWV) were assessed before and approximately one month after RFA.Results. There were 14 residual tumors after RFA. VTI showed that all the tumors were darker after RFA. VTI was not able to distin

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Yi, Huiming, Baohuan Cai, Xi Ai, Kaiyan Li, Pengfei Song, and Wei Zhang. "Early Identification of Residual Tumors following Microwave Ablation Using Contrast-Enhanced Ultrasonography in a Rabbit VX2 Liver Cancer Model." BioMed Research International 2020 (September 27, 2020): 1–9. http://dx.doi.org/10.1155/2020/2462058.

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Objective. It is difficult to evaluate the ablation effect immediately after thermal ablation of liver cancer by clinical imaging methods, due to the immediate formation of an annular inflammatory reaction band (IRB). This study is aimed at exploring the early identification indicators of the IRB and residual tumor postmicrowave ablation (MVA) using contrast-enhanced ultrasonography (CEUS). Methods. MVA was used to inactivate part of the tumor nodules in rabbit VX2 liver cancer models, leading to the coexistence of the IRB with residual tumors. Quantitative analysis of the perfusion parameters

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Widhalm, Georg, Stefan Wolfsberger, Matthias Preusser, et al. "Residual nonfunctioning pituitary adenomas: prognostic value of MIB-1 labeling index for tumor progression." Journal of Neurosurgery 111, no. 3 (2009): 563–71. http://dx.doi.org/10.3171/2008.4.17517.

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Object In residual nonfunctioning pituitary adenomas, reliable prognostic parameters indicating probability of tumor progression are needed. The Ki 67 expression/MIB-1 labeling index (LI) is considered to be a promising candidate factor. The aim in the present study was to analyze the clinical usefulness of MIB-1 LI for prognosis of tumor progression. Methods The authors studied a cohort of 92 patients with nonfunctioning pituitary adenomas. Based on sequential postoperative MR images, patients were classified as tumor free (51 patients) or as harboring residual tumor (41 individuals). The res

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Wang, Zhiming, Hala S. Hassanain, Erin He, et al. "Abstract P3-02-28: A combination approach to target residual tumors via ferroptosis induction." Clinical Cancer Research 31, no. 12_Supplement (2025): P3–02–28—P3–02–28. https://doi.org/10.1158/1557-3265.sabcs24-p3-02-28.

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Abstract Background: Selection pressure from chemotherapy can result in small populations of resistant cells, even in tumors with apparent clinical response. These residual tumor cells can tolerate cytotoxic treatments, persist in a reversible, semi-dormant, diapause-like state, and ultimately drive tumor recurrence. Pharmacologically targeting these residual tumor cells has the potential to prevent or significantly delay tumor relapse, but it remains a clinical challenge. Methods and Results: We report ferroptosis induction as a targeting strategy to eradicate residual tumor cells following c

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De Santis, Maria, Alexander Becherer, Carsten Bokemeyer, et al. "2-18fluoro-deoxy-D-glucose Positron Emission Tomography Is a Reliable Predictor for Viable Tumor in Postchemotherapy Seminoma: An Update of the Prospective Multicentric SEMPET Trial." Journal of Clinical Oncology 22, no. 6 (2004): 1034–39. http://dx.doi.org/10.1200/jco.2004.07.188.

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Purpose To define the clinical value of 2-18fluoro-deoxy-D-glucose positron emission tomography (FDG PET) as a predictor for viable residual tumor in postchemotherapy seminoma residuals in a prospective multicentric trial. Patients and Methods FDG PET studies in patients with metastatic pure seminoma who had radiographically defined postchemotherapy residual masses were correlated with either the histology of the resected lesion or the clinical outcome documented by computer tomography (CT), tumor markers, and/or physical examination during follow-up. The size of the residual lesions on CT, ei

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Lusch, A., and P. Albers. "Residual tumor resection (RTR)." World Journal of Urology 35, no. 8 (2016): 1185–90. http://dx.doi.org/10.1007/s00345-016-1984-2.

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Theodosopoulos, Philip V., James Leach, Robert G. Kerr, et al. "Maximizing the extent of tumor resection during transsphenoidal surgery for pituitary macroadenomas: can endoscopy replace intraoperative magnetic resonance imaging?" Journal of Neurosurgery 112, no. 4 (2010): 736–43. http://dx.doi.org/10.3171/2009.6.jns08916.

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Object Endoscopic approaches to pituitary tumors have become an effective alternative to traditional microscopic transsphenoidal approaches. Despite a proven potential to decrease unexpected residual tumor, intraoperative MR (iMR) imaging is infrequently used even in the few operating environments in which such technology is available. Its use is prohibitive because of its cost, increased complexity, and longer operative times. The authors assessed the potential of intrasellar endoscopy to replace the need for iMR imaging without sacrificing the maximum extent of resection. Methods In this ret

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Park, Jung Ho, So Eun Ahn, Sanghwa Kim, Mi Jung Kwon, Yong Joon Suh, and Doyil Kim. "Complete Surgical Excision Is Necessary following Vacuum-Assisted Biopsy for Breast Cancer." Current Oncology 29, no. 12 (2022): 9357–64. http://dx.doi.org/10.3390/curroncol29120734.

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Vacuum-assisted breast biopsy (VABB) has been replacing excisional biopsy in the treatment of benign breast lesions. Complete surgical excision is still needed for the lesions occasionally diagnosed with breast cancer after VABB. We aimed to characterize residual tumors after VABB and define a subset of patients who do not need surgical excision after VABB. From a retrospective database, we identified patients diagnosed with breast cancer after VABB guided with ultrasonography. Patients who underwent stereotactic biopsies were excluded. We reviewed clinicopathologic data and radiologic finding

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Morita, Yoshihiro, Macall Leslie, Hiroyasu Kameyama, et al. "Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer." Cancers 12, no. 3 (2020): 725. http://dx.doi.org/10.3390/cancers12030725.

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Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45+ immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual human breast tumors. While CD45 level was significantly elevated in DOX-treated wildtype mice, it remained unchanged in DOX-treated tumors from E-selectin null mice. Similarly, intravenous administration of anti-E-selectin aptamer (ESTA) resulted in a significant reduction in CD45+ immune cell densit

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Maskey, Pukar, Pawan Raj Chalise, Uttam Kumar Sharma, Prem Raj Gyawali, Guna Kumar Shrestha, and Bhola Raj Joshi. "Role of second transurethral resection in determining residual tumor in nonmuscle-invasive bladder cancer." Journal of Society of Surgeons of Nepal 20, no. 2 (2017): 35–42. http://dx.doi.org/10.3126/jssn.v20i2.24379.

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Introduction: Presence of residual tumors is not an uncommon event after transurethral resection of bladder tumor, and no studies from Nepal so far has addressed this issue. We conducted this study to determine the rate of residual tumors after first transurethral resection of nonmuscle-invasive bladder cancer, and to determine the factors associated with the presence of residual tumors and upstaging of nonmuscle-invasive bladder cancer. Methods: This was a prospective observational study of 43 patients of bladder cancer who had a diagnosis of nonmuscle-invasive bladder cancer following

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Villarreal-Garza, Cynthia Mayte, Enrique Soto-Perez-de-Celis, Erika Sifuentes, et al. "Pathologic response and disease-free survival (DFS) after neoadjuvant trastuzumab (T) for HER2+ breast cancer (BC): Results from the National Cancer Institute (NCI) of Mexico." Journal of Clinical Oncology 31, no. 15_suppl (2013): e11533-e11533. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e11533.

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e11533 Background: The most accurate definition of pathologic complete response (pCR) in HER2+ BC patients (pts) receiving T-based neoadjuvant chemotherapy associated with improved DFS is controversial, particularly regarding the role of residual ductal carcinoma in situ (ypTis) and focal invasive residuals (ypT1mic). The effect of pCR on DFS in various subgroups of HER2+ BC is also uncertain. Methods: Pts with localized HER2+ BC that received T-based neoadjuvant chemotherapy at NCI between January 2007 and May 2012 were identified. We conducted an exploratory analysis of DFS in pts according

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Hawickhorst, Bryan, and Amy H. Tang. "Abstract 2497: Modeling the hidden danger of invisible tumor growth in the clinic." Cancer Research 85, no. 8_Supplement_1 (2025): 2497. https://doi.org/10.1158/1538-7445.am2025-2497.

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Abstract Tumor dormancy, relapse, and resistance are not fully understood. Residual and resistant tumor cells often persist and remain invisible for months or years, despite clean MRI/CT scans following neoadjuvant and/or adjuvant systemic therapies. In current literature reviews we see that residual tumor sizes and tumor detection thresholds can vary widely, further complicating patient prognosis and risk stratification. To address this unmet need, we developed an algorithm to model the timing, frequency, and imaging detection limits of tumor measurements to augment tumor relapse prediction w

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Decollogny, Morgane, Demeter Túrós, Astrid Chanfon, Myriam Siffert, Ismar Klebic, and Sven Rottenberg. "Abstract C034: Investigating residual disease in its spatial context in BRCA1 p53-deficient mammary tumors." Cancer Research 84, no. 22_Supplement (2024): C034. http://dx.doi.org/10.1158/1538-7445.tumbody-c034.

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Abstract Although various effective anti-cancer treatments have become available over the last decades, resistance to all available therapies remains the major cause of death of cancer patients with disseminated tumors. Striking examples are patients with triple-negative breast cancer (TNBC), which are frequently defective in the repair of DNA double strand breaks, e.g. due to loss of BRCA1 function. Because of this defect, the patients initially respond very well to DNA damage-inducing chemotherapy. Unfortunately, disseminated tumors are usually not eradicated and resistant tumor cells are ev

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Kochi, Masato, Youichi Itoyama, Shoji Shiraishi, Isao Kitamura, Toru Marubayashi, and Yukitaka Ushio. "Successful treatment of intracranial nongerminomatous malignant germ cell tumors by administering neoadjuvant chemotherapy and radiotherapy before excision of residual tumors." Journal of Neurosurgery 99, no. 1 (2003): 106–14. http://dx.doi.org/10.3171/jns.2003.99.1.0106.

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Object. The goal of this study was to confirm the effectiveness of our novel treatment strategy, neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy, which are performed before complete excision of residual tumor in patients with intracranial nongerminomatous malignant germ cell tumors (NGMGCTs). Methods. The authors treated 11 consecutive patients with NGMGCTs by applying NAT consisting of combined platinum-based chemotherapy and radiotherapy, followed by complete excision of residual tumors. The pretreatment diagnosis, based on tumor markers with or without biopsy, was y

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Taussky, Philipp, Ricky Kalra, Jeroen Coppens, Jahan Mohebali, Randy Jensen, and William T. Couldwell. "Endocrinological outcome after pituitary transposition (hypophysopexy) and adjuvant radiotherapy for tumors involving the cavernous sinus." Journal of Neurosurgery 115, no. 1 (2011): 55–62. http://dx.doi.org/10.3171/2011.2.jns10566.

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Object Stereotactic radiosurgery and fractionated stereotactic radiotherapy are commonly used in the treatment of residual or recurrent benign tumors of the skull base and cavernous sinus. A major risk associated with radiosurgical or radiotherapy treatment of residual or recurrent tumors adjacent to normal functional pituitary gland is radiation of the pituitary, which frequently leads to the development of hypopituitarism. The authors have used a technique of pituitary transposition to reduce the radiation dose to the normal pituitary gland in cases of planned radiosurgical treatment of resi

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Winter, Christian, Cigdem Bingöl, and Peter Albers. "Postchemotherapy Retroperitoneal Residual Tumor Resection for Minimal Residual Disease." European Urology Supplements 10, no. 3 (2011): e64-e70. http://dx.doi.org/10.1016/j.eursup.2011.03.013.

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Borzomati, Domenico, Giuseppe Perrone, Gennaro Nappo, et al. "Microscopic Residual Tumor After Pancreaticoduodenectomy." Pancreas 45, no. 5 (2016): 748–54. http://dx.doi.org/10.1097/mpa.0000000000000540.

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Wittekind, Christian, Carolyn C. Compton, Frederick L. Greene, and Leslie H. Sobin. "TNM residual tumor classification revisited." Cancer 94, no. 9 (2002): 2511–16. http://dx.doi.org/10.1002/cncr.10492.

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Nakamura, Hideo, Keishi Makino, Masato Kochi, Yukitaka Ushio, and Jun-ichi Kuratsu. "Evaluation of neoadjuvant therapy in patients with nongerminomatous malignant germ cell tumors." Journal of Neurosurgery: Pediatrics 7, no. 4 (2011): 431–38. http://dx.doi.org/10.3171/2011.1.peds10433.

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Object The authors evaluated the effectiveness of a neoadjuvant therapy (NAT) consisting of combined chemoand radiotherapy followed by complete resection of the residual tumor in patients with nongerminomatous malignant germ cell tumors (NGMGCTs). Methods The authors treated 14 consecutive patients in whom NGMGCTs were diagnosed based on elevated levels of the tumor markers α-fetoprotein, human chorionic gonadotropin, and the β-subunit of human chorionic gonadotropin (β-HCG). Chemotherapy and radiotherapy were performed, and after the serum tumor markers level was in the normal or near-normal

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Gugel, Isabel, Lan Kluwe, Julian Zipfel, et al. "Minimal Effect of Bevacizumab Treatment on Residual Vestibular Schwannomas after Partial Resection in Young Neurofibromatosis Type 2 Patients." Cancers 11, no. 12 (2019): 1862. http://dx.doi.org/10.3390/cancers11121862.

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Hearing-preserving partial resection of neurofibromatosis type 2 (NF2) associated vestibular schwannomas (VS) is a preferred treatment strategy, particularly for children and adolescents. However, the residual tumors do grow and lead at some point to continued hearing deterioration. An adjuvant bevacizumab treatment may provide an option for slowing down this process. In this retrospective study, we reviewed tumor volume and hearing data of 16 operated VS in nine patients younger than 30 years over a period of 63 to 142 months. All these patients had one or more bevacizumab treatment periods a

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Friedman, Jonathan A., James J. Lynch, Jan C. Buckner, Bernd W. Scheithauer, and Corey Raffel. "Management of Malignant Pineal Germ Cell Tumors with Residual Mature Teratoma." Neurosurgery 48, no. 3 (2001): 518–23. http://dx.doi.org/10.1097/00006123-200103000-00011.

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Abstract OBJECTIVE The treatment of intracranial mixed germ cell tumors presents a unique challenge, since eradication of malignant tumor by radiation and/or chemotherapy may spare the benign tumor component. We reviewed our surgical experience with residual malignant pineal germ cell tumors after neoadjuvant therapy. METHODS Between 1987 and 1997, 16 patients with malignant intracranial germ cell tumors were treated at the Mayo Clinic with a protocol of neoadjuvant chemotherapy and radiation therapy. After the diagnosis was confirmed by histopathological examination, all patients were treated

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Albagoush, Sara, Jonathan Gootee, Kevin Nguyen, Sarah J. Aurit, Christina Curtin, and Peter T. Silberstein. "The importance of surgical margins in dedifferentiated liposarcoma survival." Journal of Clinical Oncology 37, no. 15_suppl (2019): e22528-e22528. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e22528.

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e22528 Background: Among the types of soft tissue sarcomas (STS), liposarcoma is the most common malignant STS. Considering therapeutic options, surgical resection is the most utilized therapeutic option. In this study, we aim to explore the effects of varying degrees of surgical margins on survival in patients with dedifferentiated liposarcoma. Methods: The National Cancer Database (NCDB) was used to select patients with dedifferentiated liposarcoma to determine if surgical margins and other variables were associated with worse overall survival after accounting for age, gender, race, Charlson

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Losa, Marco, Pietro Mortini, Raffaella Barzaghi, et al. "Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence." Journal of Neurosurgery 108, no. 3 (2008): 525–32. http://dx.doi.org/10.3171/jns/2008/108/3/0525.

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Object Nonfunctioning pituitary adenomas (NFPAs) are benign tumors of the pituitary gland that typically cause visual and/or hormonal dysfunction. Surgery is the treatment of choice, but patients remain at risk for tumor recurrence for several years afterwards. The authors evaluate the early results of surgery and the long-term risk of tumor recurrence in patients with NFPAs. Methods Between 1990 and 2005, 491 previously untreated patients with NFPA underwent surgery at the Università Vita-Salute. Determinations of recurrence or growth of the residual tumor tissue during the follow-up period w

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Kinoshita, Osamu, Masayoshi Nakanishi, Yasutoshi Murayama, Yoshiaki Kuriu, Yukihito Kokuba, and Eigo Otsuji. "Flattened Tumor Requires a More Careful Attention for Residual Distal Cancer Spread in Locally Advanced Lower Rectal Carcinoma after Chemoradiotherapy." Digestive Surgery 32, no. 3 (2015): 159–65. http://dx.doi.org/10.1159/000371586.

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Background/Aims: Limited data are available on distal resection margin (DRM) for lower rectal cancer (LRC) after preoperative chemoradiotherapy (pre-CRT); thus, we aimed to establish the criteria for DRMs as estimated by the macroscopic tumor appearance. Methods: This was a pathological study using whole-mount sections that included the entire circumference of tumor. Residual cancer spread located most distally from the macroscopic tumor border was mainly evaluated. Results: A retrospective cohort of 42 consecutive patients with locally advanced LRC after pre-CRT was enrolled, and 38 patients

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Germanwala, Anand V., Jeffrey C. Mai, Nestor D. Tomycz, et al. "Boost Gamma Knife surgery during multimodality management of adult medulloblastoma." Journal of Neurosurgery 108, no. 2 (2008): 204–9. http://dx.doi.org/10.3171/jns/2008/108/2/0204.

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Object The aim of this paper was to determine prognostic factors for adult medulloblastoma treated with boost Gamma Knife surgery (GKS) following resection and craniospinal irradiation. Methods The authors performed a retrospective analysis of 12 adult patients with histologically proven medulloblastoma or supratentorial primitive neuroectodermal tumor who between February 1991 and December 2004 underwent ≥ 1 sessions of GKS for posttreatment residual or recurrent tumors (6 tumors in each group). Before GKS, all patients had undergone a maximal feasible resection followed by craniospinal irrad

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Maletkovic, Jelena, Asmaa Dabbagh, Dongyun Zhang, et al. "Residual Tumor Confers a 10-Fold Increased Risk of Regrowth in Clinically Nonfunctioning Pituitary Tumors." Journal of the Endocrine Society 3, no. 10 (2019): 1931–41. http://dx.doi.org/10.1210/js.2019-00163.

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Abstract Objective We evaluated tumor recurrence and regrowth rates following endoscopic transnasal transsphenoidal (TNTS) surgical removal in a consecutive series of clinically nonfunctioning pituitary adenomas (CNFTs). Design Retrospective chart review of clinical, biochemical, and sellar MRI findings in all TNTS surgeries in patients with CNFT, performed by a single surgeon, between 2008 and 2015 (n = 280). Patients Ninety-three patients met eligibility criteria, with complete clinical, biochemical, and imaging follow-up for a 3-year minimum. Results Of 85 patients who were not irradiated,

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Bhide, Shreerang, Jen Lee, Isaac Garcia-Murillas, et al. "Predicting response to radical (chemo)radiotherapy (R-CRT) with circulating HPV DNA and tumor DNA (ctDNA) analysis in locally-advanced head and neck squamous cell carcinoma (LAHNC)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 6043. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6043.

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6043 Background: Following R-CRT for human papilloma virus positive (HPV+) and negative (HPV-) LAHNC, patients frequently undergo unnecessary neck dissection (ND) and/or repeated biopsies for abnormal PET-CT findings even in the presence of a complete pathological response (pCR), which causes significant morbidity. We assessed the role of circulating tumor DNA analysis in identifying patients with true residual disease. Methods: We prospectively recruited development (DC, n=55) and test (TC, n=33) cohorts of LAHNC patients having R-CRT. For HPV+ tumors we developed a novel amplicon based next

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Baldock, Anne, Russell Rockne, Sunyoung Ahn, et al. "Patient-specific biomathematical model to predict benefit of resection in human gliomas." Journal of Clinical Oncology 31, no. 15_suppl (2013): e13017-e13017. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e13017.

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e13017 Background: Gliomas are incurable, primary brain tumors noted for their invasion of brain parenchyma. Our goal was to apply a biomathematical model to estimate the overall tumor invasiveness on an individual basis and determine whether the estimated number of residual glioma cells after resection of any extent is predictive of survival. Methods: Estimates of net rates of proliferation (ρ) and diffusion (D) of glioma cells, based on a biomathematical model of cell density, yield a ratio describing relative invasiveness (ρ/D). This metric was derived for 185 contrast enhancing gliomas fro

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Sato, Hiroshi, Takuji Kaburaki, Masahiro Niihara, et al. "Risk Factors for Residual Tumors in Surgery Following Neoadjuvant Chemotherapy for Esophageal Cancer." International Surgery 103, no. 11-12 (2019): 572–77. http://dx.doi.org/10.9738/intsurg-d-17-00048.1.

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Neoadjuvant chemotherapy (NAC) followed by esophagectomy is considered the standard treatment for resectable advanced esophageal squamous cell carcinoma in Japan. The purpose of this study was to identify the risk factors for residual tumors in surgery following NAC. We herein described risk factors for residual tumors in surgery following neoadjuvant chemotherapy for thoracic esophageal cancer. We reviewed the medical records of patients in our institution selected by using the following criteria: (1) pathologically confirmed squamous cell carcinoma or adenosquamous carcinoma before treatment

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Juvekar, Parikshit, Erickson Torio, Wenya Linda Bi, Dhiego Chaves De Almeida Bastos, Alexandra J. Golby, and Sarah F. Frisken. "Mapping Resection Progress by Tool-Tip Tracking during Brain Tumor Surgery for Real-Time Estimation of Residual Tumor." Cancers 15, no. 3 (2023): 825. http://dx.doi.org/10.3390/cancers15030825.

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Surgical resection continues to be the primary initial therapeutic strategy in the treatment of patients with brain tumors. Computerized cranial neuronavigation based on preoperative imaging offers precision guidance during craniotomy and early tumor resection but progressively loses validity with brain shift. Intraoperative MRI (iMRI) and intraoperative ultrasound (iUS) can update the imaging used for guidance and navigation but are limited in terms of temporal and spatial resolution, respectively. We present a system that uses time-stamped tool-tip positions of surgical instruments to genera

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Forsyth, P. A., E. Petrov, H. Mahallati, et al. "Prospective study of postoperative magnetic resonance imaging in patients with malignant gliomas." Journal of Clinical Oncology 15, no. 5 (1997): 2076–81. http://dx.doi.org/10.1200/jco.1997.15.5.2076.

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PURPOSE We studied the natural history of postoperative enhancement on magnetic resonance (MR) scans in patients with malignant glioma to determine the following: (1) when a postoperative MR scan most accurately shows residual enhancing tumor; and (2) whether repeated doses of the contrast agent gadopentetate dimeglumine (Gd-DTPA) were well tolerated. PATIENTS AND METHODS Seventeen patients with malignant glioma underwent tumor resection; four (24%) had nonenhancing tumors preoperatively. Serial MR scans were performed on postoperative days 1, 3, 5, 7, 14, and 21 and were analyzed qualitativel

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Miyake, Yohei, Susumu Ito, Mio Tanaka, and Yukichi Tanaka. "Spontaneous regression of infantile dural-based non-Langerhans cell histiocytosis after surgery: case report." Journal of Neurosurgery: Pediatrics 15, no. 4 (2015): 372–79. http://dx.doi.org/10.3171/2014.10.peds14378.

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The authors report the case of a large left occipital mass lesion in an 8-month-old boy who presented with seizure. Neuroimaging demonstrated an approximately 5-cm extraaxial tumor, and the patient underwent partial resection. The tumor was strongly attached to the tentorium and falx. In the postoperative course the residual lesion regressed spontaneously, and after 5 years only a slight residual tumor remained along the tentorium. Histopathological examination of the tumor revealed non-Langerhans cell histiocytosis (non-LCH). However, the tumor was not diagnosed as juvenile xanthogranuloma (J

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Zinko, Galyna, Marianna Hrebenyuk, Anders Kjellman, Yngve Forslin, and Martin Delle. "Factors that Affect Outcome of Ultrasound-Guided Radiofrequency Ablation of Renal Masses." Current Oncology 31, no. 9 (2024): 5318–29. http://dx.doi.org/10.3390/curroncol31090392.

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The purpose of this study was to examine the factors influencing the efficacy and safety of the ultrasound-guided radiofrequency ablation of renal tumors. Between January 2010 and December 2018, 159 patients with renal tumors treated with ultrasound-guided percutaneous radiofrequency ablation at our institution were included in this study. Biopsies were performed for histopathological analysis prior to each ablation. Patients underwent computed tomography follow-ups at 3, 6, and 12 months and were subsequently observed on an annual basis. The primary efficacy rate (i.e., residual tumor), local

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Eliseu, Miguel, Vera Marques, Hugo Antunes, et al. "Results of Repeat Transurethral Resection of Bladder Tumor After Macroscopically Complete Primary Resection." Acta Urológica Portuguesa 37, no. 1-2 (2022): 7–11. http://dx.doi.org/10.24915/aup.37.1-2.147.

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Introduction: Non-muscle invasive (NMI) bladder cancers (BC) account for 75% of BC cases, and most are initially diagnosed and treated with transurethral resection of bladder tumor (TURB). After primary TURB, a repeat resection (rTURB) should be carried out in cases of incomplete resection; however, rTURB is recommended by EAU guidelines in pT1 tumors even when the completeness of the original resection is believed by the surgeon, with reported rates of residual tumor in up to 33%-55% and upstaging in up to 25%. Since the quality of initial resection impacts in the result of a rTURB, these rat

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Mohammadi, Alireza Mohammad, T. Barrett Sullivan, Gene H. Barnett, et al. "Use of High-Field Intraoperative Magnetic Resonance Imaging to Enhance the Extent of Resection of Enhancing and Nonenhancing Gliomas." Neurosurgery 74, no. 4 (2013): 339–50. http://dx.doi.org/10.1227/neu.0000000000000278.

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ABSTRACT BACKGROUND: Intraoperative magnetic resonance imaging (IoMRI) is used to improve the extent of resection of brain tumors. Most previous studies evaluating the utility of IoMRI have focused on enhancing tumors. OBJECTIVE: To report our experience with the use of high-field IoMRI (1.5 T) for both enhancing and nonenhancing gliomas. METHODS: An institutional review board–approved retrospective review was performed of 102 consecutive glioma patients (104 surgeries, 2010-2012). Pre-, intra-, and postoperative tumor volumes were assessed. Analysis was performed with the use of volumetric T2

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Kawai, Taketo, Haruki Kume, Keiji Inoue, et al. "Reduction of residual tumors by photodynamic diagnosis-assisted TURBT using 5-aminolevulinic acid for high-risk nonmuscle-invasive bladder cancer (BRIGHT study)." Journal of Clinical Oncology 40, no. 6_suppl (2022): 489. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.489.

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489 Background: High-risk non-muscle invasive bladder cancer (NMIBC) has high tumor residual rate of 40–60% after TURBT, and second TUR is strongly recommended. Photodynamic diagnosis-assisted TURBT (PDD-TURBT) using 5-aminolevulinic acid (5-ALA) has been reported to reduce residual tumors and intravesical recurrence. The purpose of this study is to investigate the residual tumor-reducing effect of PDD-TURBT for high-risk NMIBC and to explore the possibility that second TUR could be omitted by PDD-TURBT. Methods: We conducted an investigator-initiated multicenter prospective observational stud

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Nampoolsuksan, Chawisa, Khajohnsak Bhocksombud, Thammawat Parakonthun, et al. "Outcomes of Microscopic Residual Tumor after Curative-Intent Surgery in Adenocarcinoma of Esophagogastric Junction." Siriraj Medical Journal 76, no. 11 (2024): 758–65. http://dx.doi.org/10.33192/smj.v76i11.269480.

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Objective: Radical surgery is the mainstay treatment for adenocarcinoma of the esophagogastric junction. The presence of microscopic residual tumor tissue after curative-intent surgery is associated with recurrence. This study compared the outcomes of patients with microscopic residual tumor (Residual+ group) and those without microscopic residual tumor (Residual- group). Material and Methods: We retrospectively reviewed the medical records of 71 patients with adenocarcinomas of the esophagogastric junction who underwent curative-intent surgery between January 2005 and August 2018. We evaluate

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Kolyadina, Irina Vladimirovna, Irina Poddubnaya, Olga Pavlikova, et al. "Features of p53 expression in residual tumors in Russian women after neoadjuvant chemotherapy of breast cancer stage T1-3N0-1." Journal of Clinical Oncology 35, no. 15_suppl (2017): e12121-e12121. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e12121.

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e12121 Background: Residual tumor is an important prognostic factor after neoadjuvant therapy, however, p53 expression in the residual breast tumors poorly understood. Methods: In our study included 164 Russian women (24-76, median age - 47) with breast cancer stage T1-3N0-1 treated in RCRC from 2004 to 2016. Biological subtype of primary tumor was luminal A (8,1%), luminal B HER2-negative (43,6%), luminal HER2+ (15,4%), triple negative (22,8%) and non-luminal HER2+ (10,1%). After neoadjuvant chemotherapy by anthracycline ± taxanes (in HER2+ cancer ± trastuzumab) patients had radical surgery.

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Guo, Fang, Bing Hu, Lei Chen, and Jia Li. "Clinical application of contrast-enhanced ultrasound after percutaneous renal tumor ablation." British Journal of Radiology 92, no. 1103 (2019): 20190183. http://dx.doi.org/10.1259/bjr.20190183.

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Objective: To evaluate the effectiveness of contrast-enhanced ultrasound (CEUS) in detecting incomplete ablation and local recurrence of renal tumors after percutaneous radiofrequency ablation (RFA). Methods: 31 patients were included for RFA treatment and underwent CEUS examination after RFA, ablation zone and contrast distribution in the ablation area were observed, CEUS images were compared with enhanced CT/MRI images to determine the residual tumors and local recurrence of renal tumors. Results: The average maximum diameters of the tumor and the ablation zone after the first RFA were 32.3

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Prada, Francesco, Massimiliano Del Bene, Riccardo Fornaro, et al. "Identification of residual tumor with intraoperative contrast-enhanced ultrasound during glioblastoma resection." Neurosurgical Focus 40, no. 3 (2016): E7. http://dx.doi.org/10.3171/2015.11.focus15573.

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OBJECTIVE The purpose of this study was to assess the capability of contrast-enhanced ultrasound (CEUS) to identify residual tumor mass during glioblastoma multiforme (GBM) surgery, to increase the extent of resection. METHODS The authors prospectively evaluated 10 patients who underwent surgery for GBM removal with navigated ultrasound guidance. Navigated B-mode and CEUS were performed prior to resection, during resection, and after complete tumor resection. Areas suspected for residual tumors on B-mode and CEUS studies were localized within the surgical field with navigated ultrasound and sa

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Vuky, Jacqueline, Manjit Bains, Jennifer Bacik, et al. "Role of Postchemotherapy Adjunctive Surgery in the Management of Patients With Nonseminoma Arising From the Mediastinum." Journal of Clinical Oncology 19, no. 3 (2001): 682–88. http://dx.doi.org/10.1200/jco.2001.19.3.682.

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PURPOSE: To evaluate the role of postchemotherapy surgery in patients with nonseminomatous germ cell tumors arising from the anterior mediastinum. PATIENTS AND METHODS: Thirty-two patients with nonseminoma arising from a mediastinal primary site were treated on a clinical trial at our center, and they underwent postchemotherapy surgery. The results of postchemotherapy surgical resection, frequency of viable tumor found during postchemotherapy surgery, and prognostic factors for survival were assessed. RESULTS: Complete resection of all gross residual disease was achieved in 27 patients (84%).

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Valcz, Gábor, Edit I. Buzás, Anna Sebestyén, et al. "Extracellular Vesicle-Based Communication May Contribute to the Co-Evolution of Cancer Stem Cells and Cancer-Associated Fibroblasts in Anti-Cancer Therapy." Cancers 12, no. 8 (2020): 2324. http://dx.doi.org/10.3390/cancers12082324.

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Analogously to the natural selective forces in ecosystems, therapies impose selective pressure on cancer cells within tumors. Some tumor cells can adapt to this stress and are able to form resistant subpopulations, parallel with enrichment of cancer stem cell properties in the residual tumor masses. However, these therapy-resistant cells are unlikely to be sufficient for the fast tumor repopulation and regrowth by themselves. The dynamic and coordinated plasticity of residual tumor cells is essential both for the conversion of their regulatory network and for the stromal microenvironment to pr

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Lupo, Barbara, Francesco Sassi, Marika Pinnelli, et al. "Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype." Science Translational Medicine 12, no. 555 (2020): eaax8313. http://dx.doi.org/10.1126/scitranslmed.aax8313.

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Blockade of epidermal growth factor receptor (EGFR) causes tumor regression in some patients with metastatic colorectal cancer (mCRC). However, residual disease reservoirs typically remain even after maximal response to therapy, leading to relapse. Using patient-derived xenografts (PDXs), we observed that mCRC cells surviving EGFR inhibition exhibited gene expression patterns similar to those of a quiescent subpopulation of normal intestinal secretory precursors with Paneth cell characteristics. Compared with untreated tumors, these pseudodifferentiated tumor remnants had reduced expression of

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Hattori, Masaya, Padma Sheila Rajagopal, Lise Sveen, et al. "Genomic profiling of residual tumor after neoadjuvant chemotherapy for breast cancer." Journal of Clinical Oncology 37, no. 15_suppl (2019): e12106-e12106. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e12106.

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e12106 Background: Patients who have residual disease after neoadjuvant chemotherapy (NAC) have a higher risk of metastatic recurrence. Residual disease likely includes therapy-resistant subclones of breast cancer cells, which untreated lead to metastases. The aim of this study was to identify additional adjuvant therapies based on genomic profiling of residual disease post NAC therapy. Methods: Next-generation sequencing of tumor samples from patients (pts) with residual invasive breast cancer after NAC was performed using a Tempus xT, 595 gene panel on matched tumor-normal samples. All sampl

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Zhang, Jianxin, Xiaogang Lv, Hengbo Zhang, and Bin Liu. "AResU-Net: Attention Residual U-Net for Brain Tumor Segmentation." Symmetry 12, no. 5 (2020): 721. http://dx.doi.org/10.3390/sym12050721.

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Automatic segmentation of brain tumors from magnetic resonance imaging (MRI) is a challenging task due to the uneven, irregular and unstructured size and shape of tumors. Recently, brain tumor segmentation methods based on the symmetric U-Net architecture have achieved favorable performance. Meanwhile, the effectiveness of enhancing local responses for feature extraction and restoration has also been shown in recent works, which may encourage the better performance of the brain tumor segmentation problem. Inspired by this, we try to introduce the attention mechanism into the existing U-Net arc

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Han, Rachel, Steffi Regpala, Elzbieta Slodkowska, et al. "Lack of Standardization in the Processing and Reporting of Post-Neoadjuvant Breast Cancer Specimens." Archives of Pathology & Laboratory Medicine 144, no. 10 (2020): 1262–70. http://dx.doi.org/10.5858/arpa.2019-0539-oa.

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Context.— The use of neoadjuvant therapy in the management of early-stage invasive breast cancer is increasing. Residual Cancer Burden and other similar tools use pathologic characteristics of post-neoadjuvant therapy breast tumors to determine long-term outcome. However, there are no standardized guidelines for the pathologic evaluation of these specimens in the routine clinical setting. Objective.— To assess current practices among Canadian pathologists and pathology assistants with regard to the processing and reporting of post-neoadjuvant therapy breast specimens. Design.— An electronic su

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