Littérature scientifique sur le sujet « VNF migration »
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Articles de revues sur le sujet "VNF migration"
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Liu, Yanyang, Jing Ran, Hefei Hu et Bihua Tang. « Energy-Efficient Virtual Network Function Reconfiguration Strategy Based on Short-Term Resources Requirement Prediction ». Electronics 10, no 18 (17 septembre 2021) : 2287. http://dx.doi.org/10.3390/electronics10182287.
Texte intégralRésumé :
In Network Function Virtualization, the resource demand of the network service evolves with the change of network traffic. VNF dynamic migration has become an effective method to improve network performance. However, for the time-varying resource demand, how to minimize the long-term energy consumption of the network while guaranteeing the Service Level Agreement (SLA) is the key issue that lacks previous research. To tackle this dilemma, this paper proposes an energy-efficient reconfiguration algorithm for VNF based on short-term resource requirement prediction (RP-EDM). Our algorithm uses LSTM to predict VNF resource requirements in advance to eliminate the lag of dynamic migration and determines the timing of migration. RP-EDM eliminates SLA violations by performing VNF separation on potentially overloaded servers and consolidates low-load servers timely to save energy. Meanwhile, we consider the power consumption of servers when booting up, which is existing objectively, to avoid switching on/off the server frequently. The simulation results suggest that RP-EDM has a good performance and stability under machine learning models with different accuracy. Moreover, our algorithm increases the total service traffic by about 15% while ensuring a low SLA interruption rate. The total energy cost is reduced by more than 20% compared with the existing algorithms.
2
Wei, Yifei, Yuning Jia, Jun Li et Xiaojun Wang. « RESEARCH ON 5G NETWORK RESOURCE ORCHESTRATION ALGORITHM BASED ON NETWORK VIRTUALIZATION TECHNOLOGY ». Latin American Applied Research - An international journal 52, no 4 (25 septembre 2022) : 347–52. http://dx.doi.org/10.52292/j.laar.2022.970.
Texte intégralRésumé :
With the advancement of wireless network technology to the next generation, network function virtualization (NFV) brings the advantages of centralized scheduling of virtual wireless resources and the ability to orchestrate virtual network functions. This makes it possible to dynamically deploy and manage service function chains (SFCs) in virtualized wireless networks according to changes in network load. Through the network function virtualization technology, the DU/CU separation architecture under 5G-NG-RAN is considered. Aiming at the resource orchestration problem of the 5G access network virtual protocol stack function and service function chain after deployment, an energy-aware virtualized network function instance (VNFI) orchestration algorithm is proposed. By modeling the underlying physical network and node energy consumption, the node load, resource type, tolerable delay and migration loss are included in the decision, and the state of the general server node is divided into two types: running state and sleep state. The algorithm decouples the decision-making process of VNF migration into two specific modules, namely "the VNF selection module" and "the migration destination node selection module". It is verified by simulation that compared with other energy-saving strategies, the algorithm in this paper has better performance in reducing energy consumption and reducing migration loss, and it can take into account both the reduction of the number of open server nodes and the improvement of resource utilization.
3
Zhou, Xinhao, Bo Yi, Xingwei Wang et Min Huang. « Approach for minimising network effect of VNF migration ». IET Communications 12, no 20 (20 décembre 2018) : 2574–81. http://dx.doi.org/10.1049/iet-com.2018.5188.
Texte intégral
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Yi, Bo, Xingwei Wang, Min Huang et Kexin Li. « Design and Implementation of Network-Aware VNF Migration Mechanism ». IEEE Access 8 (2020) : 44346–58. http://dx.doi.org/10.1109/access.2020.2978002.
Texte intégral
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Qu, Hua, Ke Wang et Jihong Zhao. « Priority-awareness VNF migration method based on deep reinforcement learning ». Computer Networks 208 (mai 2022) : 108866. http://dx.doi.org/10.1016/j.comnet.2022.108866.
Texte intégral
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Yi, Bo, Xingwei Wang, Min Huang et Anwei Dong. « A multi-criteria decision approach for minimizing the influence of VNF migration ». Computer Networks 159 (août 2019) : 51–62. http://dx.doi.org/10.1016/j.comnet.2019.04.010.
Texte intégral
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Karapetjana, Indra, et Gunta Roziņa. « Lexicogrammatical aspects in English for dentistry acquisition materials ». Valoda : nozīme un forma / Language : Meaning and Form 12 (décembre 2021) : 64–73. http://dx.doi.org/10.22364/vnf.12.05.
Texte intégralRésumé :
In the 21st century, globalization and massive migration have increased the global demand for effective transnational communication skills in English in the health care workplace and academic contexts, including dentistry. English for Dentistry falls under the umbrella of English for Specific Purposes (ESP): this refers to teaching and learning English as a foreign language in a particular domain. While the role of grammar acquisition in ESP courses is often understated in the key theoretical literature on ESP, this article highlights the importance of lexicogrammatical knowledge. Dentistry students and practitioners in Latvia highly value the accuracy in communication since the knowledge of various syntactic and morphological rules of grammar and their use in the dentistry-related context contribute to the accuracy required in the performance of different communicative tasks, for instance, asking for, explaining, and providing information, giving instructions. Besides, if dentists are unable, for example, to explain a diagnosis, agree on treatment options with the patient in a meaningfully accurate way, the dentist’s authority may be undermined, resulting in unsuccessful communication. The case study reports on the tasks employing lexicogrammatical strategies in the material “Dentistry and Language Integrated Learning”, which has been developed by the authors of this article working in close collaboration with individual academic staff at the the Faculty of Medicine of the University of Latvia. The material piloted amongst both dentistry practitioners and students suggests that the applied strategies of morphological derivation, for instance, recognizing and building new words by gaining control of affixation devices, can be considered as useful tools in the new lexeme meaning-making process in dentistry. As a result, this study has attempted to support the assumption that ESP and content and language integrated learning (or CLIL) are compatible and can be efficiently mastered in the professional discourse development process.
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Alliau, Damien, Sébastien Roux et Léa Parelle. « Apports de la modélisation physique avec distorsions pour l'analyse des cours d'eau sableux : exemple de la Loire aval ». La Houille Blanche, no 2 (avril 2020) : 14–33. http://dx.doi.org/10.1051/lhb/2020013.
Texte intégralRésumé :
Création de 700 épis dans le dernier siècle, extractions massives de sable réalisées pour les besoins de l'industrie … ces actions anthropiques ont eu des conséquences graves sur le fonctionnement de la Loire : enfoncement du lit, et mauvaise alimentation des annexes fluviales notamment. Dans le cadre du plan Loire IV (2014–2020) financé notamment par l'Union européenne, et dont la maîtrise d'ouvrage est en partie portée par Voies Navigables de France (VNF), la réalisation d'un ouvrage de correction sédimentaire a été proposée au voisinage de Nantes, avec l'objectif d'engendrer un remous solide régressif. Pour les études conception morpho-sédimentaires, la Compagnie Nationale du Rhône (CNR) a proposé une modélisation hybride ou composite, qui s'appuie notamment sur un modèle numérique 2D hydro-sédimentaire ainsi qu'un modèle physique de grande dimension : 1/100 pour l'échelle de longueur avec un facteur 2 de distorsion verticale, 1/33 pour l'échelle de densité des matériaux. Ce modèle à fond mobile a été conçu pour satisfaire à deux lois de similitudes dont la combinaison produit des distorsions géométriques et de densité des matériaux. La complexité d'un tel modèle impose un grand nombre de vérifications par l'expérience qu'il faut confronter aux approches théoriques de dimensionnement : du comportement granulaire aux macro-phénomènes (dunes). Un jeu de 341 dunes formées en laboratoire pendant plus de 50 essais a été analysé selon deux axes : le premier concerne la caractérisation géométrique (hauteur, longueur) grâce à la disponibilité de Modèles Numériques de Terrain capturés par un procédé de photogrammétrie submergée, et le second est focalisé sur la vitesse de migration des dunes par Large Scale Particle Image Velocimetry (LSPIV). L'ensemble des analyses réalisées a montré la très bonne adéquation entre les résultats de laboratoire et les phénomènes ligériens de transport de sable.
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Liu, Lin, Qingzhuo Cui, Junna Song, Yang Yang, Yixin Zhang, Jiapeng Qi et Jingshan Zhao. « Hydroxysafflower Yellow A Inhibits Vascular Adventitial Fibroblast Migration via NLRP3 Inflammasome Inhibition through Autophagy Activation ». International Journal of Molecular Sciences 24, no 1 (22 décembre 2022) : 172. http://dx.doi.org/10.3390/ijms24010172.
Texte intégralRésumé :
Inflammation is closely associated with progression of vascular remodeling. The NLRP3 inflammasome is the key molecule that promotes vascular remodeling via activation of vascular adventitia fibroblast (VAF) proliferation and differentiation. VAFs have a vital effect on vascular remodeling that could be improved using hydroxysafflower yellow A (HSYA). However, whether HSYA ameliorates vascular remodeling through inhibition of NLRP3 inflammasome activation has not been explored in detail. Here, we cultured primary VAFs and analyzed the migration of VAFs induced by angiotensin II (ANG II) to determine the potential effects and mechanism of HSYA on VAF migration. The results thereof showed that HSYA remarkably inhibited ANG II-induced VAF migration, NLRP3 inflammasome activation, and the TLR4/NF-κB signaling pathway in a dose-dependent manner. In addition, it is worth noting that LPS promoted ANG II-induced VAF migration and NLRP3 inflammasome assembly, which could be significantly reversed using HSYA. Moreover, HSYA could be used to inhibit NLRP3 inflammasome activation by promoting autophagy. In conclusion, HSYA could inhibit ANG II-induced VAF migration through autophagy activation and inhibition of NLRP3 inflammasome activation through the TLR4/NF-κB signaling pathway.
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Braunsdorf, Felix. « Migration in der Agenda 2030 ». Vereinte Nationen 67, no 4 (2019) : 171–76. http://dx.doi.org/10.35998/vn-2019-0050.
Texte intégralThèses sur le sujet "VNF migration"
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Biallach, Hanane. « Optimization of VNF reconfiguration problem for 5G network slicing ». Electronic Thesis or Diss., Compiègne, 2022. http://www.theses.fr/2022COMP2707.
Texte intégralRésumé :
Ces dernières années, en raison de la croissance sans précédent du nombre d'appareils connectés et de données mobiles, et des développements continus des technologies pour répondre à cette énorme demande de données, le réseau de cinquième génération (5G) a émergé. La future architecture 5G sera essentiellement basée sur le Network Slicing (NS), qui permet de fournir une approche flexible pour réaliser la vision 5G. Grâce au concept émergent de virtualisation des fonctions réseau (NFV), les fonctions réseau sont découplées des matériels physiques dédiés et réalisées sous forme de logiciel. Cela offre plus de flexibilité et d'agilité dans les opérations commerciales. Malgré les avantages qu'il apporte, NFV soulève quelques défis techniques, le problème de reconfiguration étant l'un d'entre eux. Ce problème, qui est NP-difficile, consiste à réaffecter les fonctions de réseau virtuel (VNFs) pour s'adapter aux changements du réseau, en transformant l'état courant des services déployés, on peut illustrer cela par la migration des machines virtuelles (VM) qui hébergent les VNF, à un autre état qui répond aux objectives des opérateurs. Cette thèse de doctorat étudie comment reconfigurer les VNFs en les migrant vers un état optimal qui pourrait être calculé en avance ou inconnu. Dans cette thèse, nous avons étudié les deux cas en minimisant la durée d'interruption de service et la durée de migration des VNFs. Nous avons proposé des méthodes exactes et approchées. Parmi les méthodes exactes, nous citons deux modèles PLNE. Nous avons également proposé deux approches heuristiques, l'une basée sur la génération de colonnes et la deuxième utilisant la notion de “feedback arc set". L'objectif global de ce travail est donc de définir et d'étudier le problème de reconfiguration des VNFs dans le contexte du 5G network slicing, et de proposer des modèles mathématiques et des algorithmes efficaces pour résoudre les problèmes d'optimisation sous-jacentsIn recent years, because of the unprecedented growth in the number of connected devices and mobile data, and the ongoing developments in technologies to address this enormous data demand, the fifth generation (5G) network has emerged. The forthcoming 5G architecture will be essentially based on Network Slicing (NS), which enables provide a flexible approach to realize the 5G vision. Thanks to the emerging Network Function Virtualization (NFV) concept, the network functions are decoupled from dedicated hardware devices and realized in the form of software. This offers more flexibility and agility in business operations. Despite the advantages it brings, NFV raises some technical challenges, the reconfiguration problem is one of them. This problem, which is NP-Hard, consists in reallocating the Virtual Network Functions (VNFs) to fit the network changes, by transforming the current state of deployed services, e.g., the current placement of Virtual Machines (VM) that host VNFs, to another state that updates providers’ objectives. This PhD thesis investigates how to reconfigure the VNFs by migrating them to an optimal state that could be computed in advance or free placement. In this thesis, we studied both cases while minimizing the service interruption duration and the VNF migration duration. We have proposed exact and approximate methods. Among the exact methods, we cite two ILP models. We also proposed two heuristic approaches, one based on column generation and the second using the concept of “arc set feedback”. The overall objective of this work is therefore to define and study the problem of VNF reconfiguration problem in the context of 5G network slicing, and propose mathematical models and efficient algorithms to solve the underlying optimization problems
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Cho, Daewoong. « Network Function Virtualization (NFV) Resource Management For Low Network Latency ». Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17256.
Texte intégralRésumé :
NFV is an emerging network architecture to increase flexibility and agility within operator's networks by placing virtualized services on demand in Cloud data centers (CDCs). One of the main challenges for the NFV environment is how to efficiently allocate Virtual Network Functions (VNFs) to Virtual Machines (VMs) and how to minimize network latency in the rapidly changing network environments. Although a significant amount of work/research has been already conducted for the generic VNF placement problem and VM migration for efficient resource management in CDCs, network latency among various network components and VNF migration problem have not been comprehensively considered yet to the best of our knowledge. Firstly, to address VNF placement problem, we design a more comprehensive model based on real measurements to capture network latency among VNFs with more granularity to optimize placement of VNFs in CDCs. We consider resource demand of VNFs, resource capacity of VMs and network latency among various network components. Our objectives are to minimize both network latency and lead time (the time to find a VM to host a VNF). Experimental results are promising and indicate that our approach, namely VNF Low-Latency Placement (VNF-LLP), can reduce network latency by up to 64.24% compared with two generic algorithms. Furthermore, it has a lower lead time as compared with the VNF Best-Fit Placement algorithm. Secondly, to address VNF migration problem, we i) formulate the VNF migration problem and ii) develop a novel VNF migration algorithm called VNF Real-time Migration (VNF-RM) for lower network latency in dynamically changing resource availability. As a result of experiments, the effectiveness of our algorithm is demonstrated by reducing network latency by up to 59.45% after latency-aware VNF migrations.
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Van, Lonkhuyzen Derek Robert. « Novel modulators of cell growth and migration ». Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16549/1/Derek_Van_Lonkhuyzen_Thesis.pdf.
Texte intégralRésumé :
Recent observations have demonstrated that Insulin-like Growth Factors (IGFs) are able to form complexes with the extracellular matrix protein Vitronectin (VN). These complexes of VN:IGFBP:IGF-I significantly enhance the proliferation and migration of various cell lines including skin and corneal epithelial cells, as well as primary cells derived from human skin and corneal tissue. These enhanced effects arise from co- activation of the IGF-binding type-1 IGF receptor (IGF-1R) as well as activation of the VN-binding αv-integrins. Further studies suggest that these complexes can replace the requirement for serum in the ex vivo expansion of cells. In order to translate the VN:IGFBP:IGF-I technology into techniques for the improved culture of cells, we have designed, expressed and purified synthetic chimeric molecules, consisting of various domains of VN and mature IGF-I, using a baculovirus based expression system. The recombinant VN:IGF-I (rVN:IGF-I) chimeras were secreted into conditioned media of transfected Sf9 insect cells. Purification of the chimeras was achieved via methods including heparin-sepharose chromatography, Q-sepharose ion-exchange chromatography and Ni2+-NTA affinity chromatography. The rVN:IGF-I chimeras were detectable by Western blot analysis using a poly-clonal anti-VN antibody. Functional characterisation studies indicate that the chimeras promote cellular growth and migration to a similar extent as the VN:IGFBP:IGF-I complexes at 10x and 30x molar ratios. Additionally, function blocking antibodies directed to the IGF-1R and the VN binding αv-integrin were able to abolish this effect indicating that co-activation of these receptors is critical to the migratory effect of the chimeras. A functional chimera may lead to the development of cell culture techniques and methodologies that are devoid of xenogeneic or allogeneic support systems, thus paving the way to approved tissue engineering therapeutics that incorporate ex vivo expanded adult stem and progenitor cells.
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Van, Lonkhuyzen Derek Robert. « Novel modulators of cell growth and migration ». Queensland University of Technology, 2007. http://eprints.qut.edu.au/16549/.
Texte intégralRésumé :
Recent observations have demonstrated that Insulin-like Growth Factors (IGFs) are able to form complexes with the extracellular matrix protein Vitronectin (VN). These complexes of VN:IGFBP:IGF-I significantly enhance the proliferation and migration of various cell lines including skin and corneal epithelial cells, as well as primary cells derived from human skin and corneal tissue. These enhanced effects arise from co- activation of the IGF-binding type-1 IGF receptor (IGF-1R) as well as activation of the VN-binding αv-integrins. Further studies suggest that these complexes can replace the requirement for serum in the ex vivo expansion of cells. In order to translate the VN:IGFBP:IGF-I technology into techniques for the improved culture of cells, we have designed, expressed and purified synthetic chimeric molecules, consisting of various domains of VN and mature IGF-I, using a baculovirus based expression system. The recombinant VN:IGF-I (rVN:IGF-I) chimeras were secreted into conditioned media of transfected Sf9 insect cells. Purification of the chimeras was achieved via methods including heparin-sepharose chromatography, Q-sepharose ion-exchange chromatography and Ni2+-NTA affinity chromatography. The rVN:IGF-I chimeras were detectable by Western blot analysis using a poly-clonal anti-VN antibody. Functional characterisation studies indicate that the chimeras promote cellular growth and migration to a similar extent as the VN:IGFBP:IGF-I complexes at 10x and 30x molar ratios. Additionally, function blocking antibodies directed to the IGF-1R and the VN binding αv-integrin were able to abolish this effect indicating that co-activation of these receptors is critical to the migratory effect of the chimeras. A functional chimera may lead to the development of cell culture techniques and methodologies that are devoid of xenogeneic or allogeneic support systems, thus paving the way to approved tissue engineering therapeutics that incorporate ex vivo expanded adult stem and progenitor cells.
5
Hollier, Brett G. « IGF:VN complexes and their role in breast cell migration ». Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16639/1/Brett_G_Hollier_Thesis.pdf.
Texte intégralRésumé :
Members of the insulin-like growth factor (IGF) family are mitogenic growth factors which have been shown to play critical roles in both normal growth and development, and tumour biology. The IGF system is complex and the biological effects of the IGFs are determined by diverse interactions between many molecules, including interactions with the extracellular matrix (ECM). Recent observations have demonstrated that IGFs can associate with the ECM protein vitronectin (VN) and this interaction can modulate IGF-stimulated biological functions. It has been demonstrated previously that IGF-II can bind directly to VN, while IGF-I associates with VN indirectly via the involvement of IGF-binding proteins (IGFBPs) -2, -3, -4 and -5. As the IGF system plays important roles in both normal breast development and in the transformation and progression of breast cancer, this study aimed to describe the effects of substrate-bound IGF-I:IGFBP:VN complexes on breast cell functions and to dissect the mechanisms underlying these responses.
The studies reported in this thesis demonstrate that substrate-bound IGF-I:IGFBP:VN complexes, containing IGFBP-3 and IGFBP-5, are potent stimulators of proliferation and migration in the "normal", non-tumourigenic MCF-10A breast epithelial and MCF-7 breast carcinoma cell lines. Interestingly, substrate-bound IGF-I:IGFBP:VN complexes were less effective in increasing the migration of the metastatic MDA-MB-231 breast cancer cell line. This, however, is due to these cells expressing the αvβ3 integrin which can support a highly migratory phenotype independent of IGF-I-stimulation. Taken together this suggests a particularly important role for these complexes in stimulating a highly migratory phenotype in pre-invasive or poorly metastatic breast cells.
Studies using IGF-I analogues were also undertaken to establish if there was a requirement for ternary complex formation and the type-1-IGF receptor (IGF-1R) in the enhanced migration responses observed. These studies determined IGF-I:IGFBP:VN-stimulated migration to be dependent upon both heterotrimeric IGF-I:IGFBP:VN complex formation and activation of the IGF-1R. Furthermore, the enhanced cellular migration was abolished upon incubation of MCF-7 and MCF-10A cells with function blocking antibodies directed at VN-binding integrins and the IGF-IR. In addition, analysis of the signal transduction pathways underlying the enhanced cell migration revealed that the complexes stimulate a transient activation of the ERK/MAPK signaling pathway, while simultaneously producing a sustained activation of the PI3-K/AKT pathway. Optimal intracellular signaling required activation of both the IGF-1R and VN-binding integrins, as antibody mediated inhibition of either receptor led to substantial decreases in both ERK/MAPK and PI3-K/AKT pathway activation. Furthermore, experiments using pharmacological inhibitors of these pathways determined a pivotal role for PI3-K/AKT activation in substrate-bound IGF-I:IGFBP:VN-stimulated cell migration. In order to confirm an important role for the PI3-K/AKT pathway in these responses, wild-type and activated-AKT was transiently overexpressed in MCF-10A cells. Overexpression of both wild-type and activated-AKT further enhanced cellular migration in response to substrate-bound IGF-I:IGFBP:VN complexes. However, these responses still required co-activation of the IGF-1R and VN-binding integrins.
In an attempt to obtain a global view of the possible molecular mechanisms underpinning IGF-I:IGFBP:VN-stimulated cell migration, oligonucleotide microarrays were used to screen for candidate genes important for the observed migratory responses. The microarray studies identified 165 genes which were differentially expressed in cells migrating in response to substrate-bound IGF-I:IGFBP:VN complexes. Gene ontology and functional analysis revealed many of these genes to be significantly associated with biological functions relevant to cancer transformation and progression, including cell growth and proliferation, cell death and cellular movement. In regard to cell migration, a number of the genes identified have previously reported roles in cellular movement, migration and metastasis, which may provide future targets to augment IGF-I:IGFBP:VN-stimulated cell migration.
Taken together, the studies reported throughout this thesis have provided the first mechanistic insights into the action of IGF-I:IGFBP:VN complexes and add further evidence to support the involvement of VN-binding integrins and their co-operativity with the IGF-IR in the promotion of tumour cell migration. Importantly, identifying the molecular mechanisms by which IGF:VN complexes enhance breast cell function will lead to not only a better understanding of this critical interaction, but also aid in developing diagnostic tests and therapeutics directed at treating breast cancer.
6
Hollier, Brett G. « IGF:VN complexes and their role in breast cell migration ». Queensland University of Technology, 2007. http://eprints.qut.edu.au/16639/.
Texte intégralRésumé :
Members of the insulin-like growth factor (IGF) family are mitogenic growth factors which have been shown to play critical roles in both normal growth and development, and tumour biology. The IGF system is complex and the biological effects of the IGFs are determined by diverse interactions between many molecules, including interactions with the extracellular matrix (ECM). Recent observations have demonstrated that IGFs can associate with the ECM protein vitronectin (VN) and this interaction can modulate IGF-stimulated biological functions. It has been demonstrated previously that IGF-II can bind directly to VN, while IGF-I associates with VN indirectly via the involvement of IGF-binding proteins (IGFBPs) -2, -3, -4 and -5. As the IGF system plays important roles in both normal breast development and in the transformation and progression of breast cancer, this study aimed to describe the effects of substrate-bound IGF-I:IGFBP:VN complexes on breast cell functions and to dissect the mechanisms underlying these responses. The studies reported in this thesis demonstrate that substrate-bound IGF-I:IGFBP:VN complexes, containing IGFBP-3 and IGFBP-5, are potent stimulators of proliferation and migration in the "normal", non-tumourigenic MCF-10A breast epithelial and MCF-7 breast carcinoma cell lines. Interestingly, substrate-bound IGF-I:IGFBP:VN complexes were less effective in increasing the migration of the metastatic MDA-MB-231 breast cancer cell line. This, however, is due to these cells expressing the αvβ3 integrin which can support a highly migratory phenotype independent of IGF-I-stimulation. Taken together this suggests a particularly important role for these complexes in stimulating a highly migratory phenotype in pre-invasive or poorly metastatic breast cells. Studies using IGF-I analogues were also undertaken to establish if there was a requirement for ternary complex formation and the type-1-IGF receptor (IGF-1R) in the enhanced migration responses observed. These studies determined IGF-I:IGFBP:VN-stimulated migration to be dependent upon both heterotrimeric IGF-I:IGFBP:VN complex formation and activation of the IGF-1R. Furthermore, the enhanced cellular migration was abolished upon incubation of MCF-7 and MCF-10A cells with function blocking antibodies directed at VN-binding integrins and the IGF-IR. In addition, analysis of the signal transduction pathways underlying the enhanced cell migration revealed that the complexes stimulate a transient activation of the ERK/MAPK signaling pathway, while simultaneously producing a sustained activation of the PI3-K/AKT pathway. Optimal intracellular signaling required activation of both the IGF-1R and VN-binding integrins, as antibody mediated inhibition of either receptor led to substantial decreases in both ERK/MAPK and PI3-K/AKT pathway activation. Furthermore, experiments using pharmacological inhibitors of these pathways determined a pivotal role for PI3-K/AKT activation in substrate-bound IGF-I:IGFBP:VN-stimulated cell migration. In order to confirm an important role for the PI3-K/AKT pathway in these responses, wild-type and activated-AKT was transiently overexpressed in MCF-10A cells. Overexpression of both wild-type and activated-AKT further enhanced cellular migration in response to substrate-bound IGF-I:IGFBP:VN complexes. However, these responses still required co-activation of the IGF-1R and VN-binding integrins. In an attempt to obtain a global view of the possible molecular mechanisms underpinning IGF-I:IGFBP:VN-stimulated cell migration, oligonucleotide microarrays were used to screen for candidate genes important for the observed migratory responses. The microarray studies identified 165 genes which were differentially expressed in cells migrating in response to substrate-bound IGF-I:IGFBP:VN complexes. Gene ontology and functional analysis revealed many of these genes to be significantly associated with biological functions relevant to cancer transformation and progression, including cell growth and proliferation, cell death and cellular movement. In regard to cell migration, a number of the genes identified have previously reported roles in cellular movement, migration and metastasis, which may provide future targets to augment IGF-I:IGFBP:VN-stimulated cell migration. Taken together, the studies reported throughout this thesis have provided the first mechanistic insights into the action of IGF-I:IGFBP:VN complexes and add further evidence to support the involvement of VN-binding integrins and their co-operativity with the IGF-IR in the promotion of tumour cell migration. Importantly, identifying the molecular mechanisms by which IGF:VN complexes enhance breast cell function will lead to not only a better understanding of this critical interaction, but also aid in developing diagnostic tests and therapeutics directed at treating breast cancer.
7
Hyde, Carolyn Elizabeth. « The functional consequences of the interactions between insulin-like growth factors (IGFs), insulin-like growth factor binding proteins (IGFBPs) and vitronectin (VN) and their involvement in skin ». Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16197/1/Carolyn_Hyde_Thesis.pdf.
Texte intégralRésumé :
The insulin-like growth factor (IGF) system plays an important role in a number of disease states, such as cancer, and has also been implicated in wound and burn healing processes. Two IGF receptors, the type-1 IGF and type-2 IGF receptors, as well as six insulin-like growth factor binding proteins (IGFBP-1 to 6), have well established roles in mediating IGF activity. Earlier studies in this laboratory demonstrated that IGF-II binds to the extracellular matrix (ECM) protein vitronectin (VN), and although IGF-I does not bind directly to VN it can bind indirectly via specific IGFBPs. Therefore the aim of the research described in this thesis was to determine whether binary and ternary complexes of IGF-I/II, IGFBPs and VN affect human keratinocyte cell function. The strategy of pre-binding these complexes to the culture dishes was adopted in this study in an attempt to more accurately reflect the extracellular environment in vivo. These studies demonstrated that the binary complex of IGF-II and VN and the ternary complexes comprised of IGF-I, IGFBP-2, or 3, or 4, or 5 and VN significantly stimulated HaCaT de novo cell protein synthesis in the human keratinocyte cell line. Interestingly, these latter experiments demonstrated that although large increases in protein synthesis were observed using the ternary complexes, IGF-I/IGFBP complexes alone were responsible for the significant increases in protein synthesis and these responses are mediated via the MAPK signaling pathway. In addition, both the dimeric and trimeric complexes significantly enhanced cell migration through 12 μm TranswellsTM. Unlike the protein synthesis assays, VN was critically important in these migratory responses and highlighting the important role that integrins play in cell migration. Cell attachment assays on the other hand demonstrated that the interactions of IGFs with IGFBPs and VN did not affect cell attachment. The data encompassed within this thesis represent the first studies to provide a functional role for the interaction between IGFs, IGFBPs and VN in human keratinocytes. Taken together these results suggest that IGF/IGFBP/VN complexes may hold great potential in situations where enhanced keratinocyte cell migration and proliferation is required, such as in wound healing and skin engineering applications.
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Hyde, Carolyn Elizabeth. « The functional consequences of the interactions between insulin-like growth factors (IGFs), insulin-like growth factor binding proteins (IGFBPs) and vitronectin (VN) and their involvement in skin ». Queensland University of Technology, 2006. http://eprints.qut.edu.au/16197/.
Texte intégralRésumé :
The insulin-like growth factor (IGF) system plays an important role in a number of disease states, such as cancer, and has also been implicated in wound and burn healing processes. Two IGF receptors, the type-1 IGF and type-2 IGF receptors, as well as six insulin-like growth factor binding proteins (IGFBP-1 to 6), have well established roles in mediating IGF activity. Earlier studies in this laboratory demonstrated that IGF-II binds to the extracellular matrix (ECM) protein vitronectin (VN), and although IGF-I does not bind directly to VN it can bind indirectly via specific IGFBPs. Therefore the aim of the research described in this thesis was to determine whether binary and ternary complexes of IGF-I/II, IGFBPs and VN affect human keratinocyte cell function. The strategy of pre-binding these complexes to the culture dishes was adopted in this study in an attempt to more accurately reflect the extracellular environment in vivo. These studies demonstrated that the binary complex of IGF-II and VN and the ternary complexes comprised of IGF-I, IGFBP-2, or 3, or 4, or 5 and VN significantly stimulated HaCaT de novo cell protein synthesis in the human keratinocyte cell line. Interestingly, these latter experiments demonstrated that although large increases in protein synthesis were observed using the ternary complexes, IGF-I/IGFBP complexes alone were responsible for the significant increases in protein synthesis and these responses are mediated via the MAPK signaling pathway. In addition, both the dimeric and trimeric complexes significantly enhanced cell migration through 12 μm TranswellsTM. Unlike the protein synthesis assays, VN was critically important in these migratory responses and highlighting the important role that integrins play in cell migration. Cell attachment assays on the other hand demonstrated that the interactions of IGFs with IGFBPs and VN did not affect cell attachment. The data encompassed within this thesis represent the first studies to provide a functional role for the interaction between IGFs, IGFBPs and VN in human keratinocytes. Taken together these results suggest that IGF/IGFBP/VN complexes may hold great potential in situations where enhanced keratinocyte cell migration and proliferation is required, such as in wound healing and skin engineering applications.
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Kashyap, Abhishek S. « In vitro functional characterisation of IGF-I : VN-induced breast cancer progression ». Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/62165/1/Abhishek_Kashyap_Thesis.pdf.
Texte intégralRésumé :
Members of the insulin-like growth factor (IGF) family have been shown to play critical roles in normal growth and development, as well as in tumour biology. The IGF system is complex and the biological effects of the IGFs are determined by their diverse interactions between many molecules, including their interactions with extracellular matrix (ECM) proteins. Recent studies have demonstrated that IGFs associate with the ECM protein vitronectin (VN) through IGF-binding proteins (IGFBP) and that this interaction modulates IGF-stimulated biological functions, namely cell migration and cell survival through the cooperative involvement of the type-I IGF receptor (IGF-1R) and VN-binding integrins. Since IGFs play important roles in the transformation and progression of breast cancer and VN has been found to be over-expressed at the leading edge of breast tumours, this project aimed to describe the effects of IGF-I:VN interactions on breast cell function. This was undertaken to dissect the molecular mechanisms underlying IGF-I:VN-induced responses and to design inhibitors to block the effects of such interactions.
The studies described herein demonstrate that the increase in migration of MCF-7 breast cancer cells in response to the IGF-I:IGFBP-5:VN complex is accompanied by differential expression of genes known to be involved in migration, invasion and/or survival, including Tissue-factor (TF), Stratifin (SFN), Ephrin-B2, Sharp-2 and PAI-1. This „migration gene signature‟ was confirmed using real-time PCR analysis. Substitution of the native IGF-I within the IGF-I:IGFBP:VN complex with the IGF-I analogue, \[L24]\[A31]-IGF-I, which has a reduced affinity for the IGF-1R, failed to stimulate cell migration and interestingly, also failed to induce the differential gene expression. This supports the involvement of the IGF-1R in mediating these changes in gene expression. Furthermore, lentiviral shRNA-mediated stable knockdown of TF and SFN completely abrogated the increased cell migration induced by IGF-I:IGFBP:VN complexes in MCF-7 cells. Indeed, when these cells were grown in 3D Matrigel™ cultures a decrease in the overall size of the 3D spheroids in response to the IGF-I:IGFBP:VN complexes was observed compared to the parental MCF-7 cells. This suggests that TF and SFN have a role in complex-stimulated cell survival. Moreover, signalling studies performed on cells with the reduced expression of either TF or SFN had a decreased IGF-1R activation, suggesting the involvement of signalling pathways downstream of IGF-1R in TF- and/or SFN-mediated cell migration and cell survival. Taken together, these studies provide evidence for a common mechanism activated downstream of the IGF-1R that induces the expression of the „migration gene signature‟ in response to the IGF-I:IGFBP:VN complex that confers breast cancer cells the propensity to migrate and survive.
Given the functional significance of the interdependence of ECM and growth factor (GF) interactions in stimulating processes key to breast cancer progression, this project aimed at developing strategies to prevent such growth factor:ECM interactions in an effort to inhibit the downstream functional effects. This may result in the reduction in the levels of ECM-bound IGF-I present in close proximity to the cells, thereby leading to a reduction in the stimulation of IGF-1R present on the cell surface. Indeed, the inhibition of IGF-I-mediated effects through the disruption of its association with ECM would not alter the physiological levels of IGF-I and potentially only exert effects in situations where abnormal over expression of ECM proteins are found; namely carcinomas and hyperproliferative diseases.
In summary, this PhD project has identified novel, innovative and realistic strategies that can be used in vitro to inhibit the functions exerted by the IGF-I:IGFBP:VN multiprotein complexes critical for cancer progression, with a potential to be translated into in vivo investigations. Furthermore, TF and SFN were found to mediate IGF-I:IGFBP:VN-induced effects, thereby revealing their potential to be used as therapeutic targets or as predictive biomarkers for the efficacy of IGF-1R targeting therapies in breast cancer patients. In addition to its therapeutic and clinical scope, this PhD project has significantly contributed to the understanding of the role of the IGF system in breast tumour biology by providing valuable new information on the mechanistic events underpinning IGF-I:VN-mediated effects on breast cell functions. Furthermore, this is the first instance where favourable binding sites for IGF-II, IGFBP-3 and IGFBP-5 on VN have been identified. Taken together, this study has functionally characterised the interactions between IGF-I and VN and through innovative strategies has provided a platform for the development of novel therapies targeting these interactions and their downstream effects.
Livres sur le sujet "VNF migration"
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Simon, Alan R. Systems Migration : A Complete Reference (VNR Computer Library]). Van Nostrand Reinhold, 1993.
Trouver le texte intégralChapitres de livres sur le sujet "VNF migration"
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Zhuang, Weihua, et Kaige Qu. « Dynamic VNF Resource Scaling and Migration : A Machine Learning Approach ». Dans Wireless Networks, 85–129. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-87136-9_4.
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V. Rada, Roberta. « Die Konzeptualisierung von Grenze im deutschen und ungarischen Mediendiskurs über die Migration im Jahre 2015 ». Dans „vnd der gieng treulich, weislich vnd mëndlich mit den sachen vmb“, 116–37. Szeged, Hungary : Institut für Germanistik der Universität Szeged, 2019. http://dx.doi.org/10.14232/fest.bassola.7.
Texte intégralRésumé :
Die Migration stellt die europäischen Länder seit 2015 vor immer schwierigere und komplexere Herausforderungen. Sie wird längst nicht mehr nur im Kontext von nationalen Medienkursen sondern auch auf der gesamteuropäischen Ebene, auf der Ebene der Europäischen Union diskutiert. In der ganzen Diskussion und daher auch in den thematisch einschlägigen Mediendiskursen spielen die Landesgrenzen und deren Schutz eine wesentliche Rolle. Ziel des vorliegenden Beitrags ist es, die Wissensbestände, Denk- und Bewertungsmuster zu ermitteln, die in dem deutschsprachigen und ungarischen Mediendiskurs über die Migration im Zusammenhang mit Grenzen sprachlich vermittelt werden. Dies soll auf der Folie der Diskurslinguistik, im Rahmen einer wortorientierten, deskriptiven linguistischen Diskursanalyse erfolgen. Im Rahmen von quantitativen und qualitativen Untersuchungen sollen die mit dem deutschen Wort Grenze bzw. dem ungarischen Wort határ benannten Konzepte aufgedeckt werden. Die erzielte Analyse versteht sich als international-interlingualer Vergleich von Diskursen.
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« Advances in Fisheries Bioengineering ». Dans Advances in Fisheries Bioengineering, sous la direction de Andrew F. Barton, Robert J. Keller et Christos Katopodis. American Fisheries Society, 2008. http://dx.doi.org/10.47886/9781934874028.ch3.
Texte intégralRésumé :
Abstract<em>.</em>—The vertical slot fishway (VSF) is a hydraulic structure used to aid in the passage of fish past barriers to their natural migration. These barriers may consist of such structures as weirs, dams, culverts, and tidal barrages.
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« Advances in Fisheries Bioengineering ». Dans Advances in Fisheries Bioengineering, sous la direction de Andrew F. Barton, Robert J. Keller et Christos Katopodis. American Fisheries Society, 2008. http://dx.doi.org/10.47886/9781934874028.ch3.
Texte intégralRésumé :
Abstract<em>.</em>—The vertical slot fishway (VSF) is a hydraulic structure used to aid in the passage of fish past barriers to their natural migration. These barriers may consist of such structures as weirs, dams, culverts, and tidal barrages.
Actes de conférences sur le sujet "VNF migration"
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Sugisono, Koji, Aki Fukuoka et Hirofumi Yamazaki. « Migration for VNF Instances Forming Service Chain ». Dans 2018 IEEE 7th International Conference on Cloud Networking (CloudNet). IEEE, 2018. http://dx.doi.org/10.1109/cloudnet.2018.8549194.
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Aidi, Saifeddine, Mohamed Faten Zhani et Yehia Elkhatib. « On Optimizing Backup Sharing Through Efficient VNF Migration ». Dans 2019 IEEE Conference on Network Softwarization (NetSoft). IEEE, 2019. http://dx.doi.org/10.1109/netsoft.2019.8806678.
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Zhang, Fangyu, Hancheng Lu, Fengqian Guo et Zhuojia Gu. « Traffic Prediction Based VNF Migration with Temporal Convolutional Network ». Dans GLOBECOM 2021 - 2021 IEEE Global Communications Conference. IEEE, 2021. http://dx.doi.org/10.1109/globecom46510.2021.9685818.
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Vu, Xuan Tuong, Jangwon Lee, Quang Huy Nguyen, Kyoungjae Sun et Younghan Kim. « An architecture for enabling VNF auto-scaling with flow migration ». Dans 2020 International Conference on Information and Communication Technology Convergence (ICTC). IEEE, 2020. http://dx.doi.org/10.1109/ictc49870.2020.9289507.
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Sarrigiannis, Ioannis, Elli Kartsakli, Kostas Ramantas, Angelos Antonopoulos et Christos Verikoukis. « Application and Network VNF migration in a MEC-enabled 5G Architecture ». Dans 2018 IEEE 23rd International Workshop on Computer Aided Modeling and Design of Communication Links and Networks (CAMAD). IEEE, 2018. http://dx.doi.org/10.1109/camad.2018.8514943.
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Zhang, Jinshi, Liang Li et Dong Wang. « Optimizing VNF live migration via para-virtualization driver and QuickAssist technology ». Dans ICC 2017 - 2017 IEEE International Conference on Communications. IEEE, 2017. http://dx.doi.org/10.1109/icc.2017.7997166.
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Ibrahimpasic, Amina Lejla, Bin Han et Hans D. Schotten. « AI-Empowered VNF Migration as a Cost-Loss-Effective Solution for Network Resilience ». Dans 2021 IEEE Wireless Communications and Networking Conference Workshops (WCNCW). IEEE, 2021. http://dx.doi.org/10.1109/wcncw49093.2021.9420029.
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Cho, Daewoong, Javid Taheri, Albert Y. Zomaya et Pascal Bouvry. « Real-Time Virtual Network Function (VNF) Migration toward Low Network Latency in Cloud Environments ». Dans 2017 IEEE 10th International Conference on Cloud Computing (CLOUD). IEEE, 2017. http://dx.doi.org/10.1109/cloud.2017.118.
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Mingshi, Wen, Li Junqin, Hai Tianxiang, Wang Pingping, Yin Kang, Hao Jiakai, Zhu Diwen, Yang Yang et Tong Riming. « Failure Prediction Based VNF Migration Mechanism for Multimedia Services in Power Grid Substation Monitoring ». Dans 2022 IEEE International Symposium on Broadband Multimedia Systems and Broadcasting (BMSB). IEEE, 2022. http://dx.doi.org/10.1109/bmsb55706.2022.9828707.
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Chen, Jing, Jia Chen et Hongke Zhang. « DRLEC : Multi-agent DRL based Elasticity Control for VNF Migration in SDN/NFV Networks ». Dans 2021 26th IEEE Asia-Pacific Conference on Communications (APCC). IEEE, 2021. http://dx.doi.org/10.1109/apcc49754.2021.9609866.
Texte intégralRapports d'organisations sur le sujet "VNF migration"
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Quinn, Cathy A., Philip K. Hamilton, Scott D. Kraus et Christopher K. Slay. An assessment of wounds caused by the attachment of remote sensing tags to North Atlantic right whales (Eubalaena Glacialis) : 1988 - 1997. New England Aquarium and Woods Hole Oceanographic Institution, février 2023. http://dx.doi.org/10.1575/1912/29702.
Texte intégralRésumé :
Because of the increase in usage of remote sensing tags to track the migration and movements of cetaceans, it has become increasingly important to assess the impact of such techniques on the target species. Between 1988 and 1997, 55 tags (41 satellite telemetry, 14 VHF or acoustic radio transmitter) were attached to 49 North Atlantic right whales (Eubalaena glacialis). All tags had implantable barbs or were fully implanted below the dermis. Right whales are photographically identifiable and the New England Aquarium curates the North Atlantic catalog, which currently numbers 374 individuals. The photo catalog has made it possible for tagged individuals to be tracked after the tag falls off the whale. Photo documentation during and after tagging provides an opportunity to monitor physiological effects from tags and healing responses to tags.