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Littérature scientifique sur le sujet « VP2 mutation »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "VP2 mutation"

Popa-Wagner, Ruth, Florian Sonntag, Kristin Schmidt, Jason King, and Jürgen A. Kleinschmidt. "Nuclear translocation of adeno-associated virus type 2 capsid proteins for virion assembly." Journal of General Virology 93, no. 9 (2012): 1887–98. http://dx.doi.org/10.1099/vir.0.043232-0.

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Adeno-associated virus (AAV) capsid assembly occurs in the nucleus. Newly synthesized capsid proteins VP1, VP2 and VP3 contain several basic regions (BRs), which may act as nuclear localization signals (NLSs). Mutation of BR2 and BR3, located at the VP1 and VP2 N termini, marginally reduced nuclear uptake of VP1 or VP2, but not of VP3, when expressed in the context of the whole AAV type 2 (AAV2) genome. Combined mutation of BR1, BR2 and BR3 resulted in capsids with slightly reduced amounts of VP1. Expression of isolated VP1/2 N termini revealed an influence of BR3 on nuclear transport, whilst

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Yuan, Hong, Pinghua Li, Huifang Bao, et al. "Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines." Applied Microbiology and Biotechnology 104, no. 4 (2020): 1683–94. http://dx.doi.org/10.1007/s00253-019-10280-9.

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AbstractFoot-and-mouth disease virus (FMDV), the most acid-unstable virus among picornaviruses, tends to disassemble into pentamers at pH values slightly below neutrality. However, the structural integrity of intact virion is one of the most important factors that influence the induction of a protective antibody response. Thus, improving the acid stability of FMDV is required for the efficacy of vaccine preparations. According to the previous studies, a single substitution or double amino acid substitutions (VP1 N17D, VP2 H145Y, VP2 D86H, VP3 H142D, VP3 H142G, and VP1 N17D + VP2 H145Y) in the

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Chang, Xiaoran, Lisai Zhu, Junying Hu, et al. "Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration." Viruses 13, no. 11 (2021): 2174. http://dx.doi.org/10.3390/v13112174.

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Enterovirus, like the majority of RNA viruses, evolves to survive the changeable environments by a variety of strategies. Here, we showed that HY12 virus evolved to alter its characteristics and pathogenicity by employing a non-synonymous mutation. Analyses of 5′UTR, VP1 and VP2 gene sequences revealed the existence of HY12 virus in an array of mutants defined as quasispecies. The determination of diversity and complexity showed that the mutation rate and complexity of HY12 virus quasispecies increased, while the proportion of HY12 VP1 and VP2 consensus (master) sequences decreased with increa

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Wang, Hui, Yulu Fang, Yongtao Jia, Jiajie Tang, and Changzheng Dong. "In silico epitope prediction and evolutionary analysis reveals capsid mutation patterns for enterovirus B." PLOS ONE 18, no. 8 (2023): e0290584. http://dx.doi.org/10.1371/journal.pone.0290584.

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Enterovirus B (EVB) is a common species of enterovirus, mainly consisting of Echovirus (Echo) and Coxsackievirus B (CVB). The population is generally susceptible to EVB, especially among children. Since the 21st century, EVB has been widely prevalent worldwide, and can cause serious diseases, such as viral meningitis, myocarditis, and neonatal sepsis. By using cryo-electron microscopy, the three-dimensional (3D) structures of EVB and their uncoating receptors (FcRn and CAR) have been determined, laying the foundation for the study of viral pathogenesis and therapeutic antibodies. A limited num

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Shishido-Hara, Yukiko, Shizuko Ichinose, Kayoko Higuchi, Yoshinobu Hara, and Kotaro Yasui. "Major and Minor Capsid Proteins of Human Polyomavirus JC Cooperatively Accumulate to Nuclear Domain 10 for Assembly into Virions." Journal of Virology 78, no. 18 (2004): 9890–903. http://dx.doi.org/10.1128/jvi.78.18.9890-9903.2004.

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ABSTRACT The human polyomavirus JC (JCV) replicates in the nuclei of infected cells. Here we report that JCV virions are efficiently assembled at nuclear domain 10 (ND10), which is also known as promyelocytic leukemia (PML) nuclear bodies. The major capsid protein VP1, the minor capsid proteins VP2 and VP3, and a regulatory protein called agnoprotein were coexpressed from a polycistronic expression vector in COS-7 cells. We found that VP1 accumulated to distinct subnuclear domains in the presence of VP2/VP3 and agnoprotein, while VP1 expressed alone was distributed both in the cytoplasm and in

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Bertolotti-Ciarlet, Andrea, Sue E. Crawford, Anne M. Hutson, and Mary K. Estes. "The 3′ End of Norwalk Virus mRNA Contains Determinants That Regulate the Expression and Stability of the Viral Capsid Protein VP1: a Novel Function for the VP2 Protein." Journal of Virology 77, no. 21 (2003): 11603–15. http://dx.doi.org/10.1128/jvi.77.21.11603-11615.2003.

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ABSTRACT Norwalk virus (NV) is the prototype strain of a group of noncultivable human caliciviruses responsible for epidemic outbreaks of acute gastroenteritis. The capsid protein VP1 is synthesized from a subgenomic RNA that contains two open reading frames (ORFs), ORF2 and ORF3, and the 3′ untranslated region (UTR). ORF2 and ORF3 code for the capsid protein (VP1) and a small structural basic protein (VP2), respectively. We discovered that the yields of virus-like particles (VLPs) composed of VP1 are significantly reduced when this protein is expressed from ORF2 alone. To determine how the 3′

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Stadnick, E., M. Dan, A. Sadeghi, and J. K. Chantler. "Attenuating Mutations in Coxsackievirus B3 Map to a Conformational Epitope That Comprises the Puff Region of VP2 and the Knob of VP3." Journal of Virology 78, no. 24 (2004): 13987–4002. http://dx.doi.org/10.1128/jvi.78.24.13987-14002.2004.

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ABSTRACT Ten antibody escape mutants of coxsackievirus B3 (CVB3) were used to identify nucleotide substitutions that determine viral virulence for the heart and pancreas. The P1 region, encoding the structural genes of each mutant, was sequenced to identify mutations associated with the lack of neutralization. Eight mutants were found to have a lysine-to arginine mutation in the puff region of VP2, while two had a glutamate-to-glycine substitution in the knob of VP3. Two mutants, EM1 and EM10, representing each of these mutations, were further analyzed, initially by determining their entire se

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Lim, Boon-Leong, Yongchang Cao, Tiffany Yu, and Chi-Wai Mo. "Adaptation of Very Virulent Infectious Bursal Disease Virus to Chicken Embryonic Fibroblasts by Site-Directed Mutagenesis of Residues 279 and 284 of Viral Coat Protein VP2." Journal of Virology 73, no. 4 (1999): 2854–62. http://dx.doi.org/10.1128/jvi.73.4.2854-2862.1999.

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ABSTRACT The full-length RNA genomes of a chicken embryonic fibroblast (CEF)-nonpermissive, very virulent infectious bursal disease virus (IBDV) (strain HK46) were amplified into cDNAs by reverse transcription-PCR. The full-length cDNAs were sequenced and subcloned into a eukaryotic expression vector, from which point mutations were introduced into the VP2 region by site-directed mutagenesis. The wild-type and mutated plasmids were transfected directly into CEFs to examine their ability to generate CEF-permissive recombinant viruses. Substitution of amino acid residues 279 (Asp→Asn) and 284 (A

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Battilani, Mara, Alessandra Scagliarini, Ernesto Tisato, et al. "Analysis of canine parvovirus sequences from wolves and dogs isolated in Italy." Journal of General Virology 82, no. 7 (2001): 1555–60. http://dx.doi.org/10.1099/0022-1317-82-7-1555.

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The VP2 genes of Italian canine parvovirus (CPV) type 2 strains isolated from dogs and wolves were sequenced and a three-dimensional model of the VP2 capsid protein was constructed. Two mutations were detected in the VP2 sequences of the Italian strains: one at residue 297 and one at residue 265. Variant 297 is the predominant CPV isolate in Europe, whereas variant 265 has never been detected before. The mutation at residue 265 causes a disruption in a G strand of the β-barrel in the VP2 protein. Data on strains isolated from wolves demonstrated that the same strain of CPV can circulate among

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Shishido-Hara, Yukiko, Yoshinobu Hara, Theresa Larson, Kotaro Yasui, Kazuo Nagashima, and Gerald L. Stoner. "Analysis of Capsid Formation of Human Polyomavirus JC (Tokyo-1 Strain) by a Eukaryotic Expression System: Splicing of Late RNAs, Translation and Nuclear Transport of Major Capsid Protein VP1, and Capsid Assembly." Journal of Virology 74, no. 4 (2000): 1840–53. http://dx.doi.org/10.1128/jvi.74.4.1840-1853.2000.

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ABSTRACT Human polyomavirus JC (JCV) can encode the three capsid proteins VP1, VP2, and VP3, downstream of the agnoprotein in the late region. JCV virions are identified in the nucleus of infected cells. In this study, we have elucidated unique features of JCV capsid formation by using a eukaryotic expression system. Structures of JCV polycistronic late RNAs (M1 to M4 and possibly M5 and M6) generated by alternative splicing were determined. VP1 would be synthesized from M2 RNA, and VP2 and VP3 would be synthesized from M1 RNA. The presence of the open reading frame of the agnoprotein or the l

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Thèses sur le sujet "VP2 mutation"

Romani, Bizhan. "Mutagenesis and functional studies of the HIV-1 vpr gene and Vpr protein obtained from South African virus strains." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/6702.

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Thesis (PhD)--University of Stellenbosch, 2011. ENGLISH ABSTRACT: Background: Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is an accessory protein that interacts with a number of host cellular and other viral proteins. Vpr exerts several functions such as induction of apoptosis, induction of cell cycle G2 arrest, modulation of gene expression, and suppression of immune activation. The functionality of subtype C Vpr, especially South African strains, has not been studied. The aim of this study was to describe the diversity of South African HIV-1 subtype C vpr genes

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Richards, Kathryn H. "Mutations in the vpu and env Genes of HIV-1 Can Adversely Impact Infectivity: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/378.

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The Human Immunodeficiency Virus (HIV) is able to infect CD4+ T cells as well as macrophages. Macrophage-tropism has been linked to determinants in the envelope of HIV. These determinants allow envelopes to exploit low levels of CD4 for infection. Macrophages are an important reservoir of virus, especially during chronic infection, and are likely responsible for the bulk of virus produced after CD4+T cells have declined. Viral factors that may impact the ability to infect macrophages are worth studying because this cell type is so important in infection. It was previously reported that the mac

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Vargas-Poussou, Rosa. "Etude genetique et moleculaire de deux tubulopathies de l'enfant : diabete insipide nephrogenique et syndrome de bartter (doctorat : bases cellulaires et moleculaires du fonctionnement renal normal et pathologique)." Paris 5, 1998. http://www.theses.fr/1998PA05N148.

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Studebaker, Adam Wade. "Targteing uracil exclusion mechanisms for development of anti-viral and anti-cancer therapies." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1056034774.

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Cho, Tz-Shiuan, and 卓子暄. "Effect of Point-mutation on the Adsorption of VP2 Subvinal Particles of Infectious Bursal Disease Virus to the Immobilized Nickel ions." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/03160287628966587047.

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碩士 國立中興大學 生物科技學研究所 99 The advantage of Immobilized-Metal ion Affinity Chromatography (IMAC) – one- step purification, recycling is easy, etc.- are decisive when developing large-scale purification procedures for industrial applications. Previous results indicated that SVPs can be purified directly by IMAC and the His 253 on DE loop of P domain plays an important role binding Ni2+ ions. Besides His 253, outward superficial residues on P domain of SVPs provide higher chances for Ni2+ ions binding. In this study, to search the residues this can be substituted for the binding of immob

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CHANG, CHING-KUN, and 張敬昆. "Mutation in VP1 Protein Determines the Pathogenesis of Enterovirus 71." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/rb9y78.

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博士 國防醫學院 生命科學研究所 106 Enterovirus 71 (EV71) is a member belonged to Picornaviridae family. The infection of EV71 causes outbreaks of hand-foot-mouth-disease(HFMD) and meningitis, paralysis and even death. To study the pathogenesis of EV71, we had established the transgenic mice expressing EV71 receptor for infection (hSCARB2 Tg mice). In our past study, we had unexpectedly discovered an important phenomenon; using rhabdomyosarcoma cell line (RD) to produce EV71, the progeny EV71 will be rapidly mutated and reduce its toxicity. In this study, we prepare EV71 in Vero (named as EV-V) o

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Soares, Rui Manuel da Costa. "Clinical implications of viral protein R mutations in the progression of HIV infection." Master's thesis, 2013. http://hdl.handle.net/10316/85267.

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Trabalho final de mestrado integrado em Medicina área científica de Microbiologia/Doenças Infecciosas e Pediatria, apresentado á Faculdade de Medicina da Universidade de Coimbra Acquired immune deficiency syndrome (AIDS) is caused by a chronic infection by the human immunodeficiency virus (HIV). Over the last 30 years, research in this area has made many advances on the knowledge of the genetics of the virus and the role of its components in the disease progression, thus giving rise to the development of more efficient therapeutic strategies. HIV-1 viral protein R (Vpr) is an accessory

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Chapitres de livres sur le sujet "VP2 mutation"

Morales, Yonis, and Rolando Grajeda. "Virulence genes of new population of coffee rust (Hemileia vastatrix) affecting coffee variety 'Lempira', in Honduras; resistant and susceptible varieties." In Mutation breeding, genetic diversity and crop adaptation to climate change. CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0035.

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Abstract The coffee variety 'Lempira', released in Honduras in 1998, was classified 100% resistant to races I and II of coffee rust identified by Portugal's Centre for Research into Coffee Rusts (Centro de Investigação das Ferrugens do Cafeeiro) (CIFC) in 1997. However, since 2007, the disease has been reported in seed foundation plots and producer farms, the most recent epidemic report being in April 2016 in Vegas de Jalan, Juticalpa Olancho, affecting 210 ha. Since this variety constitutes 45% of the cultivated area under coffee in the country, there is a need to identify the virulence genes

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Banta, M. M., and S. D. Emr. "VPS33." In Secretory Pathway. Oxford University PressOxford, 1994. http://dx.doi.org/10.1093/oso/9780198599425.003.0145.

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Abstract Cells carrying a mutation in VPS33 secrete multiple vacuolar hydrolases5 and exhibit extreme defects in vacuole morphology. These cells lack a compartment resembling a wild-type vacuole but accumulate many small vesicles and other aberrant membranous structures, typical of Class C vps mutants36. vps33 null mutants and most spontaneous vps33 mutants are unable to grow at 37°C but exhibit defects in vacuole protein localization and morphology even at permissive temperature. One vps33 temperature-sensitive mutant contains a missense mutation that results in a conditional phenotype; this

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Rani, Manisha, Sushma Rajyalakshmi, Sunitha Pakalapaty, and Nagamani Kammilli. "Norovirus Structure and Classification." In Norovirus. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98216.

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Norovirus are a major cause of acute gastroenteritis worldwide. Diarrheal disease is now the fourth common cause of mortality children under the age of 5 years but remain the 2nd most cause of morbidity. NoV are associated with 18% diarrheal diseases worldwide where rotavirus vaccinations has been successfully introduced. NoV has become major cause of gastroenteritis in children. NoV belong to family caliciviridae. They are non-enveloped, single stranded positive sense RNA Viruses. The genome consists of 3 Open reading frames, ORF-1 codes for non-structural protein, ORF-2 codes for major capsi

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Raymond, C. K., and T. H. Stevens. "VPS27." In Secretory Pathway. Oxford University PressOxford, 1994. http://dx.doi.org/10.1093/oso/9780198599425.003.0143.

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Abstract Strains bearing mutations within the VPS27 gene share phenotypic characteristics in common with mutants representing at least twelve other vps complementation groups1. These mutants secrete modest amounts (30-60%) of the newly synthesized soluble vacuolar protein carboxypeptidase Y (CPY). Proteolytic processing of the intracellular proCPY is normal1·3 Similarly, visual inspection and/or vacuolar vital staining of these mutant strains suggests they assemble a relatively normal vacuolar compartment.

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Gissen, Paul, and Eamonn R. Maher. "VPS33B and the Arthrogryposis, Renal Dysfunction, and Cholestasis Syndrome." In Inborn Errors Of Development. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195306910.003.0161.

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Abstract Arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome (OMIM 208085) is a severe multisystem autosomal recessive disorder 2rst described in the 1970s, and to date, approximately 50 cases of ARC have been reported (see Gissen et al., 2006 and references within). Although the variability in liver biopsy 2ndings initially suggested possible genetic heterogeneity, Horslen et al., 1994 coined the eponym of ARC syndrome and reported that although the hepatic changes may show intrafamilial variability, the other features were usually consistent. Subsequently a high prevalence of i

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Rapports d'organisations sur le sujet "VP2 mutation"

Antignus, Yehezkiel, Ernest Hiebert, Shlomo Cohen, and Susan Webb. Approaches for Studying the Interaction of Geminiviruses with Their Whitefly Vector Bemisia tabaci. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604928.bard.

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The DNA of tomato yellow leaf curl virus (TYLCB) was detected in its whitefly vector, Bemisia tabaci, by dot spot hybridization as early as 1 h after acquisition access. The retention of the virus nucleic acid in the vector was at least 23 days after a 48 h acquisition access. However, the retention of TYLCV coat protein did not exceed 10 days. No replicative forms of TYLCV could be detected in B. tabaci, indicating a non-propagative relationship with the vector. Whiteflies were not able to accumulate naked virion ssDNA, virus cloned dsDNA, or virions with impaired coat protein. Deletion, fram

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