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Letteratura scientifica selezionata sul tema "Acoustic drug delivery"

Autore: Grafiati

Pubblicato: 10 dicembre 2022

Ultima modifica: 28 gennaio 2023

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Articoli di riviste sul tema "Acoustic drug delivery"

1

Pawar, Pankaj P., e Dipti G. Phadtare. "Acoustic Mediated Drug Delivery System". Research Journal of Pharmaceutical Dosage Forms and Technology 8, n. 1 (2016): 55. http://dx.doi.org/10.5958/0975-4377.2016.00008.2.

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2

Pourmehran, Oveis, Maziar Arjomandi, Benjamin Cazzolato, Zhao Tian, Sarah Vreugde, Shari Javadiyan, Alkis J. Psaltis e Peter-John Wormald. "Acoustic drug delivery to the maxillary sinus". International Journal of Pharmaceutics 606 (settembre 2021): 120927. http://dx.doi.org/10.1016/j.ijpharm.2021.120927.

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3

Lewis, George, William Olbricht e George Lewis. "Acoustic targeted drug delivery in neurological tissue". Journal of the Acoustical Society of America 122, n. 5 (2007): 3007. http://dx.doi.org/10.1121/1.2942740.

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4

Masterson, Jack, Brett Kluge, Aaron Burdette e George Lewis Sr. "Sustained acoustic medicine; sonophoresis for nonsteroidal anti-inflammatory drug delivery in arthritis". Therapeutic Delivery 11, n. 6 (giugno 2020): 363–72. http://dx.doi.org/10.4155/tde-2020-0009.

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Background: Arthritis pain is primarily managed by nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac. Topical diclofenac gel is limited in efficacy due to its limited penetration through the skin. This study investigates the use of a multihour, wearable, localized, sonophoresis transdermal drug delivery device for the penetration enhancement of diclofenac through the skin. Materials & methods: A commercially available, sustained acoustic medicine (sam®) ultrasound device providing 4 h, 1.3 W, 132 mW/cm2, 3 MHz ultrasound treatment was evaluated for increasing the drug delivery of diclofenac gel through a human skin model and was compared with standard of care topical control diclofenac gel. Results: Sonophoresis of the diclofenac gel for 4 h increases diclofenac delivery by 3.8× (p < 0.01), and penetration by 32% (p < 0.01). Conclusion: Sustained acoustic medicine can be used as a transdermal drug-delivery device for nonsteroidal anti-inflammatory drugs.

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Hu, Mengyi, Xuemei Ge, Xuan Chen, Wenwei Mao, Xiuping Qian e Wei-En Yuan. "Micro/Nanorobot: A Promising Targeted Drug Delivery System". Pharmaceutics 12, n. 7 (15 luglio 2020): 665. http://dx.doi.org/10.3390/pharmaceutics12070665.

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Micro/nanorobot, as a research field, has attracted interest in recent years. It has great potential in medical treatment, as it can be applied in targeted drug delivery, surgical operation, disease diagnosis, etc. Differently from traditional drug delivery, which relies on blood circulation to reach the target, the designed micro/nanorobots can move autonomously, which makes it possible to deliver drugs to the hard-to-reach areas. Micro/nanorobots were driven by exogenous power (magnetic fields, light energy, acoustic fields, electric fields, etc.) or endogenous power (chemical reaction energy). Cell-based micro/nanorobots and DNA origami without autonomous movement ability were also introduced in this article. Although micro/nanorobots have excellent prospects, the current research is mainly based on in vitro experiments; in vivo research is still in its infancy. Further biological experiments are required to verify in vivo drug delivery effects of micro/nanorobots. This paper mainly discusses the research status, challenges, and future development of micro/nanorobots.

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Allen, John S. "Acoustic fields and forces in drug delivery applications". Journal of the Acoustical Society of America 144, n. 3 (settembre 2018): 1750. http://dx.doi.org/10.1121/1.5067755.

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Nie, Luzhen, Sevan Harput, James R. McLaughlan, David Cowell, Thomas Carpenter e Steven Freear. "Acoustic microbubble trapping for enhanced targeted drug delivery". Journal of the Acoustical Society of America 141, n. 5 (maggio 2017): 4012. http://dx.doi.org/10.1121/1.4989218.

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Anosov, A. A., O. Yu Nemchenko, Yu A. Less, A. S. Kazanskii e A. D. Mansfel’d. "Possibilities of acoustic thermometry for controlling targeted drug delivery". Acoustical Physics 61, n. 4 (luglio 2015): 488–93. http://dx.doi.org/10.1134/s1063771015040028.

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9

Park, E. J., K. I. Jung e S. W. Yoon. "Acoustic mechanisms as an enhancer for transdermal drug delivery". Journal of the Acoustical Society of America 107, n. 5 (maggio 2000): 2788. http://dx.doi.org/10.1121/1.428968.

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10

Kooiman, Klazina, Hendrik J. Vos, Michel Versluis e Nico de Jong. "Acoustic behavior of microbubbles and implications for drug delivery". Advanced Drug Delivery Reviews 72 (giugno 2014): 28–48. http://dx.doi.org/10.1016/j.addr.2014.03.003.

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Più fonti

Tesi sul tema "Acoustic drug delivery"

1

Diaz, de la Rosa Mario Alfonso. "High-frequency ultrasound drug delivery and cavitation /". Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1679.pdf.

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Hallow, Daniel Martin. "Measurement and Correlation of Acoustic Cavitation with Cellular and Tissue Bioeffects". Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/19741.

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Targeted intracellular delivery is a goal of many novel drug delivery systems to treat site-specific diseases thereby increasing the effectiveness of drugs and reducing side effects associated with current drug administration. The development of ultrasound-enhanced delivery is aimed at providing a targeted means to deliver drugs and genes intracellularly by utilizing ultrasound s ability to non-invasively focus energy into the body and generate cavitation, which has been found to cause transient poration of cells. To address some of the current issues in this field, the goals of this study were (i) to develop a measurement of cavitation to correlate with cellular bioeffects and (ii) to evaluate the ability of ultrasound to target delivery into cells in viable tissue. In addition, this study sought to exploit the shear-based mechanism of cavitation by (iii) developing a simplified device to expose cells to shear stress and cause intracellular uptake of molecules. This study has shown that broadband noise levels of frequency spectra processed from cavitation sound emissions can be used to quantify the kinetic activity of cavitation and provide a unifying parameter to correlate with the cellular bioeffects. We further demonstrated that ultrasound can target delivery of molecules into endothelial and smooth muscle cells in viable arterial tissue and determined approximate acoustic energies relevant to drug delivery applications. Lastly, we developed a novel device to expose cells to high-magnitude shear stress for short durations by using microfluidics and demonstrated the ability of this method to cause delivery of small and macromolecules into cells. In conclusion, this work has advanced the field of ultrasound-enhanced delivery in two major areas: (i) developing a real-time non-invasive measurement to correlate with intracellular uptake and viability that can be used as means to predict and control bioeffects in the lab and potentially the clinic and (ii) quantitatively evaluating the intracellular uptake into viable cells in tissue due to ultrasound that suggest applications to treat cardiovascular diseases and dysfunctions. Finally, by using shear forces generated in microchannels, we have fabricated a simple and inexpensive device to cause intracellular uptake of small and large molecules, which may have applications in biotechnology.

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Diaz, Mario Alfonso. "High-Frequency Ultrasound Drug Delivery and Cavitation". BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/1050.

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The viability of a drug delivery system which encapsulates chemotherapeutic drugs (Doxorubicin) in the hydrophobic core of polymeric micelles and triggers release by ultrasound application was investigated at an applied frequency of 500 kHz. The investigation also included elucidating the mechanism of drug release at 70 kHz, a frequency which had previously been shown to induce drug release. A fluorescence detection chamber was used to measure in vitro drug release from both Pluronic and stabilized micelles and a hydrophone was used to monitor bubble activity during the experiments. A threshold for release between 0.35 and 0.40 in mechanical index was found at 70 kHz and shown to correspond with the appearance of the subharmonic signal in the acoustic spectrum. Additionally, drug release was found to correlate with increase in subharmonic emission. No evidence of drug release or of the subharmonic signal was detected at 500 kHz. These findings confirmed the role of cavitation in ultrasonic drug release from micelles. A mathematical model of a bubble oscillator was solved to explore the differences in the behavior of a single 10 um bubble under 70 and 500 kHz ultrasound. The dynamics were found to be fundamentally different; the bubble follows a period-doubling route to chaos at 500 kHz and an intermittent route to chaos at 70 kHz. It was concluded that this type of "intermittent subharmonic" oscillation is associated with the apparent drug release. This research confirmed the central role of cavitation in ultrasonically-triggered drug delivery from micelles, established the importance of subharmonic bubble oscillations as an indicator, and expounded the key dynamic differences between 70 and 500 kHz ultrasonic cavitation.

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Crake, Calum. "Targeting and characterisation of magnetic microbubbles for drug delivery using passive acoustic mapping". Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:4a69d29f-296c-474b-b88f-d4c87b5fcc50.

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Passive acoustic mapping (PAM) is a versatile technique for monitoring of therapeutic ultrasound, in particular the generation of cavitation and subsequent bubble dynamics. The objective of this thesis was to apply PAM to investigate the activity of different types of cavitation agent and any correlation to therapeutic effects. The work focuses particularly on a new type of agent in the form of microbubbles that can be magnetically targeted, which have shown great potential for localised drug delivery. In this thesis PAM was used to study the behaviour of magnetic microbubbles (MMB) in tissue phantoms, in vitro cell experiments and in vivo mouse models. In tissue phantoms magnetic localisation of microbubble-induced cavitation activity was demonstrated and resolved using PAM. Under clinically relevant flow conditions an increase in the energy of cavitation on the order of 2-5 times was observed using PAM, which was similar to doubling the injected microbubble dose. To facilitate cell experiments a novel chamber system was used with improved variants of MMB as well as condensed magnetic nanodroplets which were shown to enhance uptake of fluorescent small interfering RNA (siRNA), transfection of knockdown siRNA and paclitaxel-induced cell kill. Magnetic targeting was associated with increased cavitation power in PAM as well as increased treatment efficacy measured by biological methods including fluorescence microscopy and flow cytometry. Finally, improved MMB were tested for the first time in vivo under real-time B-mode imaging and PAM, followed by fluorescence and MR imaging to assess distribution. MMB cavitation activity was of similar magnitude to the commercial contrast agent SonoVue®. Cavitation induced by the microbubbles and magnetic targeting were both associated with increases in fluorescence and MRI contrast in tumours. The therapeutic potential of MMB and monitoring power of PAM were thus demonstrated.

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Chen, Di. "Applications of Acoustic Techniques to Targeting Drug Delivery and Dust Removal Relevant to NASA Projects". ScholarWorks @ UVM, 2010. http://scholarworks.uvm.edu/graddis/44.

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Sonoporation, enhanced by ultrasound contrast agents has been explored as a promising non-viral technique to achieve gene transfection and targeting drug delivery in recent years. However, the short lifespan of traditional ultrasound contrast agents like Optison® microbubbles under moderate intensity ultrasound exposure limits their application. Liposomes, as drug carriers consisting of curved spherical closed phospholipid bilayer shells, have the following characteristics: 1) The ability to encapsulate and carry hydrophilic or hydrophobic molecules. 2) The biocompatibility with cell membranes. 3) The nanometer size and the relative ease of adding special ligands to their surface to target a specific disease site. 4) The stability in the blood stream. 5) Targeted ultrasound irradiation can induce rupture of liposomes letting the drug encapsulated in them leak out to achieve controlled release of the therapeutic agents at a certain concentration and a delivery rate. In this thesis, several liposome synthesis methods are presented. Liposomes synthesized in our laboratory were characterized acoustically and optically. Anti rabbit IgG conjugated with Alexafluor 647 was delivered into Jurkat cells in a suspension containing liposomes by 10 % duty cycle ultrasound tonebursts of 2.2 MHz (the in situ spatially averged and temporally averaged intensity, ISATA = 80W/cm2) with an efficiency of 13 %. It has been experimentally shown that liposomes may be an alternative stable agent to Optison® to cause sonoporation. Furthermore, a type of nanometer-sized liposome (<300nm) was synthesized to explore the feasibility of ultrasound-triggered release from drug encapsulated lipsomes. It has been demonstrated encapsulated fluorescence materials (FITC) can be released from liposomes with an average diameter of 210 nm when exposed to high intensity focused ultrasound (HIFU) at 1.142MHz (ISPTA= 900 W/cm2). Rupture of relatively large liposomes (>100nm) and porelike defects in the membrane of small liposomes due to the excitation of HIFU were the main causes of the content release. The great enhancement of HIFU-mediated release in the nanometer-sized liposomes may prove useful for clinical applications. The presence of fine particles in Martian and lunar soil poses a significant threat to NASA’s viable long-term exploration and habitation of either the moon or Mars. It has been experimentally shown that the acoustic levitating radiation force produced by a 13.8 kHz 128 dB sound-level standing wave between a 3 cm-aperture acoustic tweeter and a reflector separated by 9 cm is strong enough to overcome the van der Waals adhesive force between the dust-particles and the reflector-surface. The majority of fine particles (> 2μm diameter) on a reflector surface can be dislodged and removed by a technique combining acoustic levitation and airflow methods. This dust removal technique may be used in space-stations or other enclosures for habitation.

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Razavi, Mashoof Arash. "High intensity focused ultrasound in ophthalmology : part one, transscleral drug delivery : part two, infrared thermography for scalable acoustic characterization, an application in the manufacture of a glaucoma treatment device". Phd thesis, Université Claude Bernard - Lyon I, 2014. http://tel.archives-ouvertes.fr/tel-00996286.

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Therapeutic ultrasound has become a topic of growing interest in ophthalmology. High intensity focused ultrasound (HIFU) for the treatment of glaucoma and ultrasound (US) drug delivery are the two main areas of research in this field. This work addresses these domains in two separate parts: transscleral ultrasound drug delivery (USDD), and infrared (IR) field characterization of an ophthalmic HIFU device for glaucoma treatment. The sclera is a promising pathway for ocular drug delivery, since transscleral administration can address both the anterior and posterior segments of the eye. Due to the low permeability however, efficient drug delivery is challenging. In this study, HIFU was investigated as a potential modality for an enhanced transscleral drug delivery (in vitro). Among US effects, cavitation was shown to be the major contributor to an enhanced USDD. A pulsed US protocol designed to maximum cavitation activity may therefore be a viable method for enhancing ocular drug delivery. In the second part, a new method of ultrasonic field characterization was developed for a multi-element HIFU device. This system is designed and produced for glaucoma treatment by Eyetechcare Company (Rillieux-la-Pape, France). The traditional hydrophone method for field characterization was prohibitively slow on an industrial scale. An alternative modality for rapid qualitative assessment of the intensity distribution based on infra-red (IR) thermography was developed specific to this high frequency (19-21 MHz) device with line-focus US radiators. The second part of the study was aimed to expand the application of a R&D technique for ultrasonic field characterization to an industrial scale

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7

Bhargava, Aarushi. "Dynamics of smart materials in high intensity focused ultrasound field". Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/97994.

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Smart materials are intelligent materials that change their structural, chemical, mechanical, or thermal properties in response to an external stimulus such as heat, light, and magnetic and electric fields. With the increase in usage of smart materials in many sensitive applications, the need for a remote, wireless, efficient, and biologically safe stimulus has become crucial. This dissertation addresses this requirement by using high intensity focused ultrasound (HIFU) as the external trigger. HIFU has a unique capability of maintaining both spatial and temporal control and propagating over long distances with reduced losses, to achieve the desired response of the smart material. Two categories of smart materials are investigated in this research; shape memory polymers (SMPs) and piezoelectric materials. SMPs have the ability to store a temporary shape and returning to their permanent or original shape when subjected to an external trigger. On the other hand, piezoelectric materials have the ability to convert mechanical energy to electrical energy and vice versa. Due to these extraordinary properties, these materials are being used in several industries including biomedical, robotic, noise-control, and aerospace. This work introduces two novel concepts: First, HIFU actuation of SMP-based drug delivery capsules as an alternative way of achieving controlled drug delivery. This concept exploits the pre-determined shape changing capabilities of SMPs under localized HIFU exposure to achieve the desired drug delivery rate. Second, solving the existing challenge of low efficiency by focusing the acoustic energy on piezoelectric receivers to transfer power wirelessly. The fundamental physics underlying these two concepts is explored by developing comprehensive mathematical models that provide an in-depth analysis of individual parameters affecting the HIFU-smart material systems, for the first time in literature. Many physical factors such as acoustic, material and dynamical nonlinearities, acoustic standing waves, and mechanical behavior of materials are explored to increase the developed models' accuracy. These mathematical frameworks are designed with the aim of serving as a basic groundwork for building more complex smart material-based systems under HIFU exposure.
Doctor of Philosophy
Smart materials are a type of intelligent materials that have the ability to respond to external stimuli such as heat, light, and magnetic fields. When these materials respond, they can change their structural, thermodynamical, mechanical or chemical nature. Due to this extraordinary property, smart materials are being used in many applications including biomedical, robotic, space, microelectronics, and automobile industry. However, due to increased sensitivity and need for safety in many applications, a biologically safe, wireless, and efficient trigger is required to actuate these materials. In this dissertation, sound is used as an external trigger to actuate two types of smart materials: shape memory polymers (SMPs) and piezoelectric materials. SMPs have an ability to store a temporary (arbitrarily deformed) shape and return to their permanent shape when exposed to a trigger. In this dissertation, focused sound induced thermal energy acts as a trigger for these polymers. A novel concept of focused ultrasound actuation of SMP-based drug delivery capsules is proposed as a means to solve some of the challenges being faced in the field of controlled drug delivery. Piezoelectric materials have an ability to generate electric power when an external mechanical force is applied and vice versa. In this study, sound pressure waves supply the external force required to produce electric current in piezoelectric disks, as a method for achieving power transfer wirelessly. This study aims to solve the current problem of low efficiency in acoustic power transfer systems by focusing sound waves. This dissertation addresses the fundamental physics of high intensity focused ultrasound actuation of smart materials by developing comprehensive mathematical models and systematic experimental investigations, that have not been performed till now. The developed models enable an in-depth analysis of individual parameters including nonlinear material behavior, acoustic nonlinearity and resonance phenomena that affect the functioning of these smart systems. These mathematical frameworks also serve as groundwork for developing more complex systems.

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Ibrahim, Houssam. "Implantation cochléaire sur audition résiduelle : conservation des structures anatomiques neurosensorielles". Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10244.

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La surdité de perception est généralement la conséquence de la mort des cellules ciliées et de la dégénérescence supplémentaire des innervations afférentes induite par une absence de stimulation. Les indications de l’implant cochléaire se sont élargies en direction des patients sourds qui présentent un reliquat d’audition exploitable dans les fréquences graves. La persistance d’un reliquat auditif suffisant après l’intervention permet parfois une stimulation électrique acoustique, amplifiée acoustique sur les fréquences graves préservées, et électrique sur les fréquences aiguës. Actuellement, plusieurs protocoles de préservation de l’audition sont en investigation. Chaque protocole vise à appliquer des procédures qui minimisent les deux mécanismes du traumatisme, à savoir trauma immédiat et trauma différé. En particulier, une insertion atraumatique du porte-électrode (Flex EAS et Flex Soft ; Med-El) a été proposée pour minimiser le traumatisme chirurgical intracochléaire. L’application local et concomitante de médicament devrait améliorer la tolérance du tissu et donc réduire les dommages intracochléaire au niveau cellulaire. Un cathéter (Med-El) intra cochléaire pour la délivrance de médicaments intracochléaire a été développé, destiné à l’utilisation d’agents pharmacologiques in situ avant l'insertion du porte-électrode. Les propriétés mécaniques de ce cathéter n’induit pas de traumatisme dans la cochlée. Une insertion séquentielle de cathéter et de porte-électrodes est réalisable et souvent atraumatique
Sensorineural deafness is generaly the result of hair cell death and additional degeneration of afferent innervation. In recent years the candidacy criteria for cochlear implantation have been expanding, and now include patients with severe to profound high-frequency hearing loss along with mild to moderate low-frequency loss. The single most important prerequisite for providing both electric and acoustic stimulation in the same ear is the preservation of acoustic hearing following the surgical procedure. Currently, several hearing preservation protocols are under investigation. Each protocol attempts to implement procedures that minimize both immediate and delayed mechanisms. Specifically, atraumatic approaches and electrode insertions (Flex EAS and Flex Soft) have been proposed that aim at minimizing the surgical aspect of intracochlear trauma. The concomitant application local of drugs should enhance tissue tolerability and thus reduce intracochlear damage on a cellular level. Acute and topical, intracochlear drug delivery prior to electrode array insertion with a disposable single-use catheter (Med-El) has been evaluated and developed. The flexible properties of this catheter are enough to be inserted without trauma in the cochlea. Sequential insertion of intracochlear catheters and electrode arrays is feasible and often atraumatic

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Rifai, Bassel. "Cavitation-enhanced delivery of therapeutics to solid tumors". Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:374b2ee1-0711-4994-8434-bf90358d9e47.

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Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The solid tumor microenvironment presents several physiological abnormalities which reduce the uptake of intravenously administered therapeutics, including leaky, irregularly spaced blood vessels, and a pressure gradient which resists transport of therapeutics from the bloodstream into the tumor. Because of these factors, a systemically administered anti-cancer agent is unlikely to reach 100% of cancer cells at therapeutic dosages, which is the efficacy required for curative treatment. The goal of this project is to use high-intensity focused ultrasound (HIFU) to enhance drug delivery via phenomena associated with acoustic cavitation. ‘Cavitation’ is the formation, oscillation, and collapse of bubbles in a sound field, and can be broadly divided into two types: ‘inertial’ and ‘stable’. Inertial cavitation involves violent bubble collapse and is associated with phenomena such as heating, fluid jetting, and broadband noise emission. Stable cavitation occurs at lower pressure amplitudes, and can generate liquid microstreaming in the bubble vicinity. It is the combination of fluid jetting and microstreaming which it is attempted to explore, control, and apply to the drug delivery problem in solid tumors. First, the potential for cavitation to enhance the convective transport of a model therapeutic into obstructed vasculature in a cell-free in vitro tumor model is evaluated. Transport is quantified using post-treatment image analysis of the distribution of a dye-labeled macromolecule, while cavitation activity is quantified by analyzing passively recorded acoustic emissions. The introduction of exogenous cavitation nuclei into the acoustic field is found to dramatically enhance both cavitation activity and convective transport. The strong correlation between inertial cavitation activity and drug delivery in this study suggested both a mechanism of action and the clinical potential for non-invasive treatment monitoring. Next, a flexible and efficient method to simulate numerically the microstreaming fields instigated by cavitating microbubbles is developed. The technique is applied to the problem of quantifying convective transport of a scalar quantity in the vicinity of acoustically cavitating microbubbles of various initial radii subject to a range of sonication parameters, yielding insight regarding treatment parameter choice. Finally, in vitro and in vivo models are used to explore the effect of HIFU on delivery and expression of a biologically active adenovirus. The role of cavitation in improving the distribution of adenovirus in porous media is established, as well as the critical role of certain sonication parameters in sustaining cavitation activity in vivo. It is shown that following intratumoral or intravenous co-injection of ultrasound contrast agents and adenovirus, both the distribution and expression of viral transgenes are enhanced in the presence of inertial cavitation. This ultrasound-based drug delivery system has the potential to be applied in conjunction with a broad range of macromolecular therapeutics to augment their bioavailability for cancer treatment. In order to reach this objective, further developmental work is recommended, directed towards improving therapeutic transducer design, using transducer arrays for treatment monitoring and mapping, and continuing the development of functionalized monodisperse cavitation nuclei.

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SMITH, DENISE ANNE BUSH. "In vitro Characterization of Echogenic Liposomes (ELIP) for Ultrasonic Delivery of Recombinant Tissue-type Plasminogen Activator (rt-PA)". University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1214234148.

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Capitoli di libri sul tema "Acoustic drug delivery"

1

P., Jociely, Jorge L.C., Sergio S. e Paulo R. "Photoacoustic Technique Applied to Skin Research: Characterization of Tissue, Topically Applied Products and Transdermal Drug Delivery". In Acoustic Waves - From Microdevices to Helioseismology. InTech, 2011. http://dx.doi.org/10.5772/18684.

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Taborda, Jaime Andrés Pérez, e Elvis O. López. "Research Perspectives on Functional Micro and Nano Scale Coatings". In Research Perspectives on Functional Micro- and Nanoscale Coatings, 136–69. IGI Global, 2016. http://dx.doi.org/10.4018/978-1-5225-0066-7.ch006.

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Research topics related to the production of nanocomposites are the most important directions of development of new semiconductor engineering, ensuring high nanocomposites obtaining useful properties in the scope of biophysical characteristics, biomedical and piezoelectric applications. We present two case studies as Hydroxyapatite are in medical applications and aluminum nitride as acoustic wave sensor. Hydroxyapatite, is the main inorganic structure of the tooth enamel and bone and is a biomaterial that is commonly used in biomedical applications that involve bone substitution, drug delivery and bone regeneration because of its excellent biocompatibility, high bioactivity and good osseoconductivity. Since the past decade. Aluminum nitride (AlN), an electrical insulating ceramic with a wide band gap of 6.3 eV, is a potentially useful dielectric material very important in fields such as optoelectronic and micro electronics.

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Taborda, Jaime Andrés Pérez, e Elvis O. López. "Research Perspectives on Functional Micro and Nano Scale Coatings". In Data Analytics in Medicine, 1076–109. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-1204-3.ch056.

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Research topics related to the production of nanocomposites are the most important directions of development of new semiconductor engineering, ensuring high nanocomposites obtaining useful properties in the scope of biophysical characteristics, biomedical and piezoelectric applications. We present two case studies as Hydroxyapatite are in medical applications and aluminum nitride as acoustic wave sensor. Hydroxyapatite, is the main inorganic structure of the tooth enamel and bone and is a biomaterial that is commonly used in biomedical applications that involve bone substitution, drug delivery and bone regeneration because of its excellent biocompatibility, high bioactivity and good osseoconductivity. Since the past decade. Aluminum nitride (AlN), an electrical insulating ceramic with a wide band gap of 6.3 eV, is a potentially useful dielectric material very important in fields such as optoelectronic and micro electronics.

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Atti di convegni sul tema "Acoustic drug delivery"

1

Ghahremani, Mohammadreza, Marjan Nabili, Sankara Mahesh, Ji Liu, David Belyea, Craig Geist, Vesna Zderic e Mona Zaghloul. "Surface Acoustic Wave devices for ocular drug delivery". In 2010 IEEE Ultrasonics Symposium (IUS). IEEE, 2010. http://dx.doi.org/10.1109/ultsym.2010.5935970.

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Qi, Aisha, James R. Friend e Leslie Y. Yeo. "Inhaled Pulmonary Drug Delivery Platform Using Surface Acoustic Wave Atomization". In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18516.

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Atomization has been widely applied in pulmonary drug delivery as a promising technology to transport drug formulations directly to the respiratory tract in the form of inhaled particles or droplets. Because of the targeted treatment, the drug can be delivered directly to the site of inflammation, thus the need for systemic exposure and the possibility of side effects are both reduced. Therefore pulmonary drug delivery has significant advantages over other methods in the treatment of respiratory diseases such as asthma. The most common atomization methods employed in pulmonary drug delivery are jet atomization and ultrasonic atomization. However, the difficulty is in producing monodispersed particles/droplets in a size range of 1–5 micron meter in diameter, necessary for deposition in the targeted lung area or lower respiratory airways, within a controllable fashion. In this paper, we demonstrate surface acoustic wave (SAW) atomization as an efficient technique to generate monodispersed aerosol to produce the required size distribution. The SAW atomizer is made of a 127.86 Y-X rotated single-crystal lithium niobate piezoelectric substrate, which is patterned with chromium-aluminum interdigital transducer (IDT) electrodes via UV lithography. When an alternating electric field is applied onto lithium niobate substrate through the IDT, a SAW, propagating across substrate surface with ten nanometer order amplitudes, is generated. When the SAW meets the liquid which is placed upon substrate, the acoustic energy carried by the wave induces atomization of the working fluid, which contains salbutamol as a model drug. In order to measure the size distribution of the atomized droplets, two methods are used. One is the laser diffraction based Spraytec technique and the other is an in-vitro lung modelthe one stage glass twin impinger. The former revealed that the mean diameter of the aerosol atomized was around 3 um which were confirmed by the lung model that demonstrated that nearly 80% of atomized drug aerosol was deposited in the simulated lung area. Moreover, the SAW atomizer only requires 1–3 W driving power, suggesting that it can be miniaturized for portable consumer use.

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Zharov, Vladimir P., e Alexei S. Latyshev. "Laser-acoustic transcutaneous drug delivery: A new trend in administration of drugs". In PHOTOACOUSTIC AND PHOTOTHERMAL PHENOMENA. ASCE, 1999. http://dx.doi.org/10.1063/1.58151.

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Ahmadi, S. A., T. Fanaei Sheikholeslami, M. Mehrjoo e S. M. Barakati. "Controlling a drug delivery micropump using surface acoustic wave correlator". In 2013 20th Iranian Conference on Biomedical Engineering (ICBME). IEEE, 2013. http://dx.doi.org/10.1109/icbme.2013.6782198.

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Fabiilli, Mario L., Ian E. Sebastian, J. Brian Fowlkes, Kullervo Hynynen e Jacques Souquet. "Development of an Acoustic Droplet Vaporization, Ultrasound Drug Delivery Emulsion". In 9TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND: ISTU—2009. AIP, 2010. http://dx.doi.org/10.1063/1.3367164.

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Lanza, Gregory M. "Acoustic Molecular Imaging and Targeted Drug Delivery with Perfluorocarbon Nanoparticles". In 4TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. AIP, 2005. http://dx.doi.org/10.1063/1.1901616.

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Akseki, Ilgaz, Christopher F. Libordi e Cetin Cetinkaya. "Non-Contact Acoustic Techniques for Drug Tablet Monitoring". In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-13940.

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Quality assurance monitoring and material characterization is of great importance in the pharmaceutical industry. If the tablet coating and/or core are defective, the desired dose delivery and bioavailability can be compromised. Tablet coatings serve a wide variety of purposes such as regulating controlled release of active ingredients in the body, contributing to the bioavailability of a particular drug or combination of drugs, during certain times and locations within the body, protecting the stomach from high concentrations of active ingredients, extending the shelf life by protecting the ingredients from degradation from moisture and oxygen, and improving the tablet's visual appeal. If a coating layer is non-uniform and/or contains surface or sub-surface defects, the desired dose delivery and bioavailability can be compromised. The Food and Drug Administration has initiated a program named the Process Analytical Technology (PAT) in order to ensure efficient quality monitoring at each stage of the manufacturing process by the integration of analytical systems into the procedure. Improving consistency and predictability of tablet action by improving quality and uniformity of tablets is required. An ideal technique for quality monitoring would be non-invasive, non-destructive, rapid, intrinsically safe and cost-effective. The objective of the current investigation was to develop, non-contact/non-destructive techniques for monitoring and evaluating drug tablets for mechanical defects such as coating layer irregularities, internal cracks and delamination using a laser-acoustic approach. In the proposed system, a pulsed laser is utilized to generate non-contact mechanical excitations and interferometric detection of transient vibrations of the drug tablets. Three novel methods to excite vibration in drug tablets are developed and employed: (i) a vibration plate excited by a pulsed-laser, (ii) pulsed laser-induced plasma expansion, and (iii) an air-coupled acoustic transducer. Nanometer-scale transient surface displacements of the drug tablets are measured using the laser interferometer. Signal processing techniques are then applied to these transient displacement responses to differentiate the defective tablets from the nominal ones. From the analysis of frequency spectra and the time-frequency spectrograms obtained under both mechanisms, it can be concluded that defective tablets can be effectively differentiated from the nominal ones.

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King, Xi, Elijah Nazarzadeh, Manlio Tassieri, Julien Reboud e Jonathan M. Cooper. "Ultrasonic Surface Acoustic Wave platform for targeted pulmonary delivery of nano drug vehicles". In 2019 IEEE International Ultrasonics Symposium (IUS). IEEE, 2019. http://dx.doi.org/10.1109/ultsym.2019.8925726.

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Meng, Long, Chun-xiang Jiang e Hai-rong Zheng. "The simulation of acoustic field in the design of ultrasound driving device for site nano-drug delivery". In 2008 Symposium on Piezoelectricity, Acoustic Waves, and Device Applications (SPAWDA). IEEE, 2008. http://dx.doi.org/10.1109/spawda.2008.4775806.

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Pourmehran, Oveis, Maziar Arjomandi, Benjamin Cazzolato e Zhao Tian. "Effect of Particle Diameter and Density on Acoustic Drug Delivery to Maxillary Sinus – a Sensitivity Study". In 22nd Australasian Fluid Mechanics Conference AFMC2020. Brisbane, Australia: The University of Queensland, 2020. http://dx.doi.org/10.14264/28fff1a.

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