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Tesi sul tema "Active oxygen – Physiological effect"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 20 febbraio 2023

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1

Gutowski, Mariusz. "Molecular detection and characterisation of biologically relevant free radicals during surgical ischaemia-reperfusion." Thesis, University of South Wales, 2011. https://pure.southwales.ac.uk/en/studentthesis/molecular-detection-and-charcaterisation-of-biologically-relevant-free-radicals-during-surgical-ischaemiareperfusion(016f6447-5d02-45f7-a543-8b880148dc23).html.

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Abstract (sommario):

Oxygen is one of the most important molecules in human beings. Our research is focused on how the human body can respond and adapt to the physiological challenge posed by a lack of oxygen. Ascorbic acid (Vitamin C) is one of the most important and considered the most effective water-soluble, chain-breaking antioxidant in human plasma, with the capacity to prevents damage by free radicals. This thesis presents four studies investigating the phenomenon of Reactive Oxygen Species (ROS) generation in the many different surgical conditions in the animal and in the human. Study one investigated the

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2

Wu, Wan Man. "Reactive oxygen species and murine malaria." Thesis, The University of Sydney, 1992. https://hdl.handle.net/2123/26446.

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The aim of this study was to investigate the role of ROS in the protective and pathological immune response during malarial infection. For this purpose, four isolates of Plasmodium parasites (P. berghei ANKA, P. vinckei, P. berghei K152 and P. chabaudi) and two different inbred strains of mice (CBA and DBA) were used. The patterns of mortality varied between the different mouseparasite strain combinatio ns. The mortality of CBA mice infected with P. vinckei and P. berghei K152, and DBA mice infected with P. berghei ANKA, related to the levels of parasitaemia. However early mortality of CBA

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3

Harris, Jessica. "BODIPY dyes for singlet oxygen and optical limiting applications." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/58002.

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A series of structurally related BODIPY dyes were synthesised and characterised. Their photophysical properties were studied in order to determine whether they would be suitable candidates for use as photosensitisers in the photodynamic therapy (PDT) treatment of cancer. The synthesis of two highly fluorescent BODIPY cores was achieved via the acid-catalysed condensation of a pyrrole and a functionalised aldehyde. In order to promote intersystem crossing, and hence improve the singlet oxygen generation of these dyes, bromine atoms were added at the 2,6-positions of the BODIPY core. These dibro

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4

Seotsanyana-Mokhosi, Itumeleng. "Photosensitizing properties of non-transition metal porphyrazines towards the generation of singlet oxygen." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1006086.

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Metallophthalocyanine complexes containing non-transition metals are very useful as sensitizers for photodynamic therapy, a cure for cancer that is based on visible light activation of tumour localized photo sensitizers. Excited sensitizers generate singlet oxygen as the main hyperactive species that destroy the tumour. Water soluble sensitizers are sought after for the convenience of delivery into the body. Thus, phthalocyanine (pc), tetrapyridinoporphyrazines (tppa) and tetramethyltetrapyridinoporphyrazines (tmtppa) with non-transition central metal atoms of Ge, Si, Sn and Zn were studied. F

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5

Bucknall, Martin Paul Medical Sciences Faculty of Medicine UNSW. "Dityrosine as a biomarker of free radical induced oxidative damage in diseases of ageing." Awarded by:University of New South Wales. School of Medical Sciences, 2006. http://handle.unsw.edu.au/1959.4/30207.

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o,o???-Dityrosine (dityrosine), an oxidation product of tyrosine produced by reaction between tyrosyl radicals, is becoming established as a biomarker of free radical oxidative protein damage in vivo. Attempts to measure dityrosine concentrations in various physiological and pathological systems have produced varied and often contradictory results. Dityrosine concentrations in urine, plasma, cerebrospinal fluid (CSF) and brain tissue varying over three orders of magnitude have been reported, together with inconsistent claims of significant dityrosine elevation in several ageing-related patho

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6

Feng, Jinliu 1974. "Mitochondrial respiratory transportation is the key determinant of aging in Caenorhabditis elegans." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32991.

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'The rate of living' hypothesis of aging speculates that the metabolic rate of a species ultimately determines its life expectancy. Using the nematode worm Caenorhabditis elegans as model system, mutation in twp-1 (t&barbelow;ime w&barbelow;arp) gene was found to significantly delay biological timing and remarkably increase mean and maximum life span. The rate of living in twp-1 is dramatically delayed in all the biological processes we tested, including rates of rhythmic adult behaviors, development, and reproduction. Oxygen consumption, which indicates metabolic rate of an organism, is reduc

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7

Lee, Fung-kwan, and 李鳳群. "Effects of æ-Lipoic acid on injury, production of nitric oxide and expression of caveolin-3 in the isolated rat heart subjected toischaemia and reperfusion." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30213915.

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8

Smith, Samson William. "Effects of Reactive Oxygen Species on Life History Traits of Caenorhabditis elegans." PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/712.

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Evolutionary life history theory predicts that tradeoffs among fitness-related phenotypes will occur as a result of resource limitations and/or physiological constraints. Such tradeoffs are defined as the cost(s) incurred on one component of fitness (e.g., reproduction) by the increased expression of another fitness-related trait (e.g., longevity). Only recently have researchers begun to investigate the mechanistic bases of life history tradeoffs. A recent proposal is that reactive oxygen species (ROS) have a central role in shaping life history traits and tradeoffs. Research on disparate anim

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9

Callow, Lisa Jane. "Oxidative stress and antioxidant intake in HIV-related wasting." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33385.

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Weight loss is a common occurrence in patients with human immunodeficiency virus (HIV) and contributes to further debilitation in the acquired immune deficiency syndrome (AIDS). Wasting syndrome (WS) is defined as 10% or more unintentional weight loss from usual body weight. The etiology of WS includes alterations in metabolism, which contribute to loss of lean body mass. Cytokine driven oxidative stress may play a critical role in the metabolic pathways that lead to HIV wasting. Studies have shown that that patients infected with HIV may have a depleted antioxidant (AO) defense system, the in

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10

Seele, Maria. "Association between antioxidant status and MnSOD Ala-9Val polymorphism in trained male athletes (rugby players) and sedentary male students controlled for antioxidant intake." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/19864.

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Thesis (MSc)--University of Stellenbosch, 2007.<br>ENGLISH ABSTRACT: The human body has developed an integrated antioxidant defence system to protect against free radical damage. Acute exercise may result in the increased generation of free radicals, including reactive oxygen species, and this may overwhelm antioxidant defence systems resulting in oxidative stress. However, it has been shown that individuals who undergo regular exercise training may have improved antioxidant capacity when compared to sedentary controls. Results from research regarding the association between antioxidant

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11

Martin, David E. "The effect of heat stress on excess post exercise oxygen consumption." Virtual Press, 1992. http://liblink.bsu.edu/uhtbin/catkey/834623.

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Abstract (sommario):

While a great deal of research has been directed towards the phenomena of excess post exercise oxygen consumption (EPOC), the effect of thermal stress on EPOC is not well defined. To assess the effect of heat stress on EPOC, seven healthy, active subjects (4 female, 3 male; 23.9 ± 2.0 years of age) performed 4 trials: one control (quiet rest) and one exercise (45 minutes of cycling at 65% VO2max workload) trial in moderate (23° C, 50% humidity) and hot (35° C, 50% humidity) environments. Oxygen consumption (V02), heart rate (HR) and rectal temperature (RT) were assessed pre, during and post co

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12

Chen, Yuan-Han. "The active site chemistry of factor inhibiting HIF-1, coordination, bonding, and reaction." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/dissertations/AAI3372258/.

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13

Xu, Fan 1960. "Effect of prolonged exercise on running economy." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68149.

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The purpose of this study was to investigate the effect of prolonged exercise on running economy. Fourteen male long distance runners performed two 90 minute runs on an outdoor 400m track at velocities equal to 65 and 80% of VO$ sb2$max. Prior to and following each 90 minute run, running economy (RE) was measured as the steady-state VO$ sb2$ during treadmill runs at speeds of 188 and 228 m/min. During the 90-min run at 65% of VO$ sb2$max, the mean weight loss was 1.3 kg. The HR was 143 bpm between minutes 5-10 and increased to 150 bpm between minutes 85-90. During the 90-min run at 80% of VO$

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14

Liu, Chia-chi. "Oxidation of ascorbate by protein radicals in simple systems and in cells." Phd thesis, Australia : Macquarie University, 2007. http://hdl.handle.net/1959.14/16746.

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Thesis (PhD) -- Macquarie University, Division of Environmental and Life Sciences, Dept. of Chemistry and Biomolecular Sciences, 2007.<br>Bibliography: leaves 295-322.<br>Generation of peroxide groups in proteins exposed to a wide variety of reactive oxygen species (ROS) requires an initial formation of protein carbon-centred or peroxyl free radicals, which can be reduced to hydroperoxides. Both protein radicals and protein hydroperoxides are capable of oxidizing important biomolecules and thus initiate biological damage. In this study, we investigated the inhibition of protein hydroperoxide f

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15

Jucht, Kathy Rae. "The influence of age on excess post-exercise oxygen consumption." Virtual Press, 1990. http://liblink.bsu.edu/uhtbin/catkey/722441.

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Abstract (sommario):

Oxygen consumption remains elevated above resting values for a variable period of time after exercise. Exercise intensity and duration, food intake, laboratory conditions, metabolic measurements, gender and age are all major factors affecting the duration and magnitude of excess post-exercise oxygen consumption (EPOC). In the present study, the influence of age on EPOC was studied in men of various fitness levels. Various metabolic measurements were collected for three distinct age groups, 18-25, 35-45, and 55-67 at rest and during exercise at 60% of maximal oxygen consumption until 200 ± 10

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16

Gibson, Robert H. "The effect of elevated core temperature upon excess post exercise oxygen consumption." Virtual Press, 1995. http://liblink.bsu.edu/uhtbin/catkey/941356.

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Abstract (sommario):

A great deal of research has been done to assess the effects of exercise intensity and duration on excess post-exercise oxygen consumption (EPOC). But the effects of an elevated core temperature (Tc) post-exercise have not been directly examined. To assess the effects of an elevated Tc on EPOC, eight healthy, active male subjects (27.5 ± 6.1 years) underwent two 45 minute exercise trials at =70% VO2max in an environmental chamber (36 °C / 10% RH) followed by a 45 minute recovery in either the environmental chamber (42 °C / 10% RH) wearing insulating clothing (HC), or in the ambient conditions

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17

Reed, Daniel Kelvin. "THE EFFECT OF HYPEROXIC GAS MIXTURES ON RECOVERY FROM SHORT-TERM MAXIMAL EXERCISE (VENTILATION, HEART RATE, PH)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276382.

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18

Zucconi, Anthony. "Regulation of the steady-state levels of B800-850 complexes in Rhodobacter capsulatus by light and oxygen." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28362.

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Abstract (sommario):

Photosynthetic organisms exhibit a variety of responses to changes in light intensity, including differential biosynthesis of chlorophyll-protein complexes. Cultures of Rhodobacter capsulatus grown anaerobically with a low intensity of light (2 W/m²) contained about four times as much B800-850 light harvesting complex as cells grown under high light intensity (140 W/m²). The mRNA transcripts encoding B800-850 beta and alpha peptides were analyzed by Northern blot, S1 nuclease protection and capping with guanylyl transferase. It was found that the steady-state levels of B800-850 mRNAs in high l

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19

Hodges, Alastair N. H. "Effect of hyperbaric oxygen on venous PO2, transcutaneous PO2, and VO2max in a normobaric environment." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30175.

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Purpose. The purpose was to examine venous PO2, transcutaneous tissue PO2 (PtcO 2), and VO2max in a normobaric environment following a single HBO2 treatment. Methods. Ten moderately trained (VO2max = 57.6 mL·kg-1·min -1) males volunteered for the study. Baseline testing included measures of VO2max, PtcO2, and anthropometry. Subjects received two HBO2 treatments, which consisted of breathing 95% oxygen at 2.5 ATA for 90 min. Following the first HBO2 treatment (6.0 +/- 1.0 min), subjects performed a VO2max test. Following the second HBO2 treatment, leg and chest PtcO2 and venous PO

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20

Martin, Pierre Gaétan. "Effect of oxygen supply during growth on the production of enzymes, cytochromes and acid end-products by Haemophilus parasuis." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74613.

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Haemophilus parasuis was grown in cystine-supplemented tryptone-yeast extract medium (TYE) sparged with CO$ sb2$-containing gas mixtures. The organism was found to metabolize glucose via acetate- and succinate-producing pathways and a complete tricarboxylic acid cycle was absent. As compared with the oxygen-sufficient organism, oxygen-restricted H. parasuis synthesized higher amounts of high and low potential cytochromes c, exhibited higher activities of the enzymes of the succinate-producing pathway and excreted less acetate and more formate and succinate. The low potential cytochromes c were

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21

Mesa, Kathryn A. "The influence of temperature, salinity, and dissolved oxygen on juvenile salmon distributions in a nearshore estuarine environment." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24863.

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This study examines the effects of a low oxygen environment, in concert with fluctuating temperature and salinity conditions, on the nearshore depth distributions (0-1 m) and flood tide movements of juvenile chinook (Oncorhynchus tshawytscha) and chum (O. keta) salmon. Comparisons are made between an unpolluted and a sewage polluted estuarine intertidal flat in the Fraser River estuary, British Columbia, the polluted area being characterized by the regular occurrence of low dissolved oxygen levels. Results are based on 380 beach seine samples taken between April and June of 1984. In general,

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22

Updyke, Rhonda S. "The Effect of Mode and Intensity on Vo2 Kinetics in the Severe Intensity Domain." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2493/.

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The purpose of this study was to evaluate the effect of mode and intensity on VO2 kinetics in the severe intensity domain. Seventeen participants completed 3-7 tests each on a cycle ergometer and treadmill. For each test, Tfatigue, VO2max, Tmean response, VO2GAIN, TVO2max and T@VO2max were determined. Linear regression techniques were used to describe the relationship between TVO2max and Tfatigue . VO2max values were higher in running. The VO2 response profile was faster for running than cycling and faster at higher intensities. The faster VO2 response in running may be associated with

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23

Kalis, Joni Kathryn. "THE EFFECT OF BETA-ADRENERGIC BLOCKADE ON THE DRIFT IN OXYGEN CONSUMPTION WITH PROLONGED EXERCISE." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/292014.

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24

Williams, Christine Suzanne. "The Effect of Running Speed on VO2 Kinetics in the Severe Exercise Domain." Thesis, University of North Texas, 1997. https://digital.library.unt.edu/ark:/67531/metadc277817/.

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Abstract (sommario):

There has been an interest in the kinetics of the V02 response during exercise at various intensities. However, most studies focus on the response of submaximal intensities whereas few studies have examined V02 kinetics at severe intensities. The purpose of this study was to evaluate the effect of exercise intensity on V02 kinetics over a range of severe intensities.

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25

Grobler, Lara. "The effect of graduated compression socks on calf muscle oxygenation of endurance athletes." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71677.

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Thesis (M Sport Sc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Compression socks (CS) are used as an ergogenic aid during and after exercise by many athletes of elite and recreational status. The exact mechanism whereby CS affect performance and postexercise recovery is not yet elucidated. Some research ascribes the beneficial effects to improved lactate removal rates with CS. One hypothesis is that CS improve venous return and thereby remove the lactate from the tissue to other tissues such as the liver, and the second hypothesis is that the CS cause retention of the lactate wi

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26

Soltesz, Zoltan. "Optogenetic investigation of the neural network underlying the oxygen modulation of C. elegans locomotion." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708419.

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27

Brown, Jeffrey D. "Frequency of the occurrence of VO2 plateau in boys and men." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115741.

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Abstract (sommario):

It has been suggested that children are less likely than adults to demonstrate a plateau in oxygen uptake (V02) at maximal exercise. However, there has been no direct comparison. Therefore, the purpose of this study was to compare boys and men in achievement of plateau as well as the secondary criteria for maximal effort: heart rate (HR), respiratory exchange ratio (RER), and blood lactate (BLa). Seventeen boys (10.7 ±v 0.6 yrs) and 21 men (22.5 ± 2.0 yrs) completed a practice exercise test and a graded exercise test in order to determine VO2max and achievement of the criteria. The men also co

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28

Odendaal, Dolf. "VO₂ en harttempo kinetika as voorspellers van fietsryprestasie." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/52051.

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29

Dickson, Tabitha Gwendoline. "Effect of ability, ascent style, and route type on psychological and physiological markers in rock climbing." Thesis, University of Canterbury. School of Sport and Physical Education, 2013. http://hdl.handle.net/10092/9444.

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Abstract (sommario):

Rock climbing is thought to rely upon the interaction of various performance components, and has previously been described as a complex multi-faceted sport. It has been suggested that psychological aspects of performance, such as task perception and the interaction of resulting pre-climb anxieties, contribute greatly to the physiological responses and the overall performance during ascent. However, research which seeks to investigate both psychological and physiological responses during specific bouts of rock climbing are few in number. This thesis attempts to contribute to the novel yet limit

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30

Gravel, Geneviève. "The oxygen cost of cycling in patients with chronic obstructive pulmonary disease and the effect of increasing ventilatory requirements /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82233.

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The objective of this study was to assess the oxygen cost of various intensities of steady-state cycling. VO2 (ml·min -1·kg-1) was measured at rest, during unloaded cycling (UL), 20 Watts, 50% (SS50) & 65% (SS65) of peak watts in 40 COPD patients (64 +/- 9 yrs; FEV1/FVC: 48 +/- 17 % predicted; FEV1:36 +/- 14 % predicted) and 28 age-matched healthy controls (CTRL). Despite higher VE (L·min -1) in COPD vs. CTRL (UL: 20.6 +/- 3.4 vs. 15.4 +/- 4.1; 20W: 24.3 +/- 4.5 vs. 17.8 +/- 4.2), VO2 at rest, at UL and 20W was not higher in COPD compared to CTRL. In addition, comparable slope and inte

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31

Wohaieb, Saleh A. "Oxygen free radical scavenging systems in clinical and experimental (chemical and spontaneous) diabetes mellitus." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/27567.

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The extent to which endogenous free radical-scavenging defense mechanisms are involved in experimental and human diabetes was investigated in various tissues of animals with chemically-induced or spontaneous diabetes (BB Wistar rats) and in erythrocytes of patients with either Type I or Type II diabetes. Diabetes was induced in female Wistar rats using alloxan (ALX) or streptozotocin (STZ), each administered in a dose of 50 mg/kg body wt., intravenously. The present study also included a group -of animals in which body wt. loss was induced by food-deprivation for 72 h. The effects of pharmaco

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32

Marvar, Paul J. "Effect of high salt intake on arteriolar responses to metabolic stimuli." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4696.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains xiv, 197 p. : ill. Vita. Includes abstract. Includes bibliographical references.

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33

Smith, Kurt, and University of Lethbridge Faculty of Arts and Science. "Men and women in hypoxia : the influence of tissue oxygenation on repeated-sprint ability." Thesis, Arts and Science, 2010. http://hdl.handle.net/10133/2548.

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This thesis examined the impact of oxygen (O2) availability on prefrontal cortex and muscle tissue oxygenation during repeated-sprint exercise (RSE) in men and women. Men and women matched for initial-sprint mechanical work performed during ten, 10-s sprints (30s of rest) in normoxia (21% FIO2) and acute hypoxia (13% FIO2). Mechanical work and arterial O2-saturation (SPO2) were obtained for every sprint. Oxy- and deoxygenated haemoglobin concentrations (O2Hb, HHb) were obtained via near-infrared spectroscopy. Hypoxia elicited lower SPO2 and work (14.8% & 7.4%, P < 0.05), larger (45.1%, P < 0.0

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34

Mungovan, Sean F., and n/a. "The Effect of Elevation and Venous Occlusion Pressure on Cardiovascular Function in Physically Active Men Who Are Paraplegic." Griffith University. School of Physiotherapy and Exercise Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040917.084824.

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Abstract (sommario):

The purpose of the present investigation was to: 1) Determine the relationship between cardiac output (estimated using the acetylene rebreathing methodology) and oxygen consumption in a homogeneous group of men who are paraplegic. 2) Investigate whether lower limb elevation increases stroke volume and decreases heart rate at rest and during submaximal arm exercise. 3) Investigate whether the application of constant circumferential pneumatic pressure applied to dependent lower limbs increases stroke volume and decreases heart rate at rest and during submaximal arm exercise.

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Mungovan, Sean F. "The Effect of Elevation and Venous Occlusion Pressure on Cardiovascular Function in Physically Active Men Who Are Paraplegic." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/365190.

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Abstract (sommario):

The purpose of the present investigation was to: 1) Determine the relationship between cardiac output (estimated using the acetylene rebreathing methodology) and oxygen consumption in a homogeneous group of men who are paraplegic. 2) Investigate whether lower limb elevation increases stroke volume and decreases heart rate at rest and during submaximal arm exercise. 3) Investigate whether the application of constant circumferential pneumatic pressure applied to dependent lower limbs increases stroke volume and decreases heart rate at rest and during submaximal arm exercise.<br>Thesis (Masters)<

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36

McCracken, Andrew. "Metabolic Support of Anaerobiosis in Embryos of the Annual Killifish Austrofundulus limnaeus." PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/600.

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Abstract (sommario):

Embryos of the annual killifish Austrofundulus limnaeus display a remarkable tolerance to anoxia during development, most notably during embryonic diapause. Little is known about the metabolic or enzymatic changes that accompany this state of anoxia tolerance. This study examined the metabolic changes associated with exposure to anoxia by measuring the activity of the enzyme phosphoenolpyruvate carboxykinase (PEPCK), and by profiling the concentration of 31 metabolites ranging from amino acids to citric cycle intermediates at 4 different developmental stages, diapause 2 (DII), 4 days post diap

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Kulakkattolickal, Augusthy Thevasia. "The effects of surface access and dissolved oxygen levels on survival time of a water-breathing and an air-breathing fish species exposed to a plant toxin (Croton tiglium, Euphorbiaceae, seed extract) /." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66223.

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38

Hagras, Muhammad A. "Overexpression of active AKT3 induces differential binding of coregulator proteins to the estrogen receptor as a possible mechanism of Tamoxifen resistance." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/688.

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Abstract (sommario):

Tamoxifen is an effective anti-estrogen for treatment of women with hormonedependent breast cancer but acquired drug resistance limits its therapeutic benefit. We have previously reported that expression of active Akt3 in MCF-7 breast cancer cells results in estrogen-independent tumors that are actually stimulated to grow after tamoxifen treatment. We hypothesize that this tamoxifen resistance may be attributed to binding of different co-regulator proteins and/or different binding affinity of these proteins to the estrogen receptor in M CF-7 cells overexpressing active Akt3 as compared to pare

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Williamson, Jon W. "Exercise Capacity Following Four Hours of Head-Down Rest in Endurance-Exercise-Trained and Untrained Subjects." Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc504298/.

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Peak oxygen uptake (VO2PEAK) in endurance exercise trained (ET =8) subjects (VO2PEAK = 61.7 1.6 ml 02.kg.min-1) was compared to the V02 PEAK of untrained (UT = 8) subjects (V02 PEAK = 38.4 1.7 ml 02 -kg.min1) after four hours of -6* head-down rest (HDR).Although both groups showed a reduction in blood volume (BV) following HDR, this decrement was greater for ET subjects (delta BV = -3.23 0.46 mi/kg; P <0.05). The ET subjects had a greater decrease in VO2=(delta 02E -5.58 1.05 ml 02-kg.min-1; P <0.05) than their UT peers (VO2PEAK = -2.44 0.79 ml02-kg.min-1). These data suggest that the greater

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Gebhard, Susanne, and n/a. "The Phn and Pst systems of Mycobacterium smegmatis : phosphate transport and gene regulation." University of Otago. Department of Microbiology & Immunology, 2006. http://adt.otago.ac.nz./public/adt-NZDU20070502.112113.

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Phosphate is an essential but often growth-limiting nutrient for bacteria. At low concentrations of phosphate in the growth medium, bacteria induce high-affinity uptake systems for phosphate, and this is usually the ABC-type phosphate specific transport system Pst. In the fully sequenced genomes of pathogenic species of mycobacteria, several copies of the genes encoding for the Pst system (pstSCAB) have been identified and some of these genes have been shown to be virulence factors. The reasons for the presence of multiple copies of pst genes in pathogenic mycobacteria are not understood, and

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41

Bennett, Wayne A. (Wayne Arden). "Responses of Selected Texas Fishes to Abiotic Factors, and an Evaluation of the Mechanisms Controlling Thermal Tolerance of the Sheepshead Minnow." Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc277819/.

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Low oxygen tolerances of ten fishes were estimated using an original nitrogen cascade design, and reciprocally transformed to express responses as ventilated volume necessary to satisfy minimal oxygen demand (L·mg O2^-1). Values ranged from 0.52 to 5.64 L·mg^-1 and were partitioned into three statistically distinct groups. Eight stream fishes showed moderately high tolerances reflecting metabolic adaptations associated with stream intermittency. Juvenile longear sunfish and two mollies comprised the second group. High tolerance of hypoxia may allow juvenile sunfish to avoid predation, and moll

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Huang, Xiaoyan. "Nitric Oxide/Peroxynitrite Balance in Kidney – Effect of Diabetes and Obesity." View abstract, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3339512.

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Brown, Anne Christine 1962. "Effects of salinity and temperature on the respiratory physiology of the Dungeness crab, Cancer magister, during development." Thesis, Thesis (Ph. D.)--University of Oregon, 1991, 1991. http://hdl.handle.net/1794/9845.

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Typescript. Includes vita and abstract. Bibliography: Includes bibliographical references (leaves 172-183).<br>Cancer magister, the Dungeness crab, occurs in different habitats during its life cycle, habitats which vary widely in the magnitude of salinity and temperature changes. Cancer magister hemocyanin also changes in structure and oxygenation properties during development. The following question was considered in this thesis: what are the effects of environmental salinity and temperature on metabolic rates, ionic and osmotic regulation and hemocyanin oxygen affinity in Q. magist

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De, Bie Gabrielle. "The effects of acute hypoxia on metabolic enzymes in skeletal muscle." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/3401.

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Thesis (MPhil (Physiological Sciences))--University of Stellenbosch, 2006.<br>The responses of central systems to oxygen deprivation have been well characterised while adaptations in peripheral systems, such as skeletal muscles, have presented confounding variations. Several reasons for these discrepancies are purported, amongst them being the duration of exposure to hypoxia and variations in fibre composition. Moreover, in real-life high altitude situations there may be a combination of factors which have the ability to modify or alter the effect of hypoxia. This study investigates the effect

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Madon, Mohd Sani. "Preparatory strategies for optimising an all-out sprint effort." University of Western Australia. School of Human Movement and Exercise Science, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0109.

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[Truncated abstract] The inclusion of a warm-up in the form of prior exercise (PE) is generally advocated as a preparatory strategy of choice to improve sprint performance. Although there is evidence that both increasing muscle temperature and mobilising the cardiorespiratory system prior to exercise contribute largely to the benefit of PE on sprint performance, their relative importance is unknown. Another important question relates to situations where an athlete has to engage in a sprint shortly after one or several earlier sprints. Under these conditions, is engaging in mild exercise also t

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Penailillo, Luis. "Muscle damage and metabolic profiles of eccentric cycling." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/706.

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Eccentric cycling, in which the knee extensor muscles perform eccentric contractions while trying to brake the backward rotational movements of the cranks of a cycle ergometer, has been shown to effectively increase muscle function and volume with a low metabolic cost. However, acute responses to repeated eccentric cycling bouts have not been well documented. Thus, the primary purposes of this PhD project were to investigate muscle damage and metabolic profiles of eccentric cycling in comparison to concentric cycling (Studies 1-3), and muscle-tendon behaviour (Study 4) during eccentric cycling

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"The dual roles of reactive oxygen species during erythropoiesis and the effect of salidroside on erythropoiesis and erythrocytes." Thesis, 2011. http://library.cuhk.edu.hk/record=b6075359.

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Abstract (sommario):

Qian, Wei.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 184-199).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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"A novel mitochondrial-localized purple acid phosphatase from soybean encoding ROS scavenging function." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074841.

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By immumolabeling and electronmicroscopy, the subcellular localization of GmPAP3 has been proved to be mainly localized in mitochondria, a primary site for ROS production. Ectopic expression of GmPAP3 in transgenic tobacco BY-2 cells mimicked the protective effects exhibited by the antioxidant ascorbic acid by: (1) increase the percentage of cells with active mitochondria; (2) reduce the percentage of dead cells; and (3) lower the accumulation of ROS under NaCl and osmotic stress treatments. However, when ectopically express a truncated GmPAP3 with the mitochondria transit peptide removed, suc

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Newnum, America Bethanne. "Bone Metabolism: The Role of STAT3 and Reactive Oxygen Species." 2013. http://hdl.handle.net/1805/3429.

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Abstract (sommario):

Indiana University-Purdue University Indianapolis (IUPUI)<br>Signal Transducers and Activators of Transcription 3 (STAT3), a transcription factor expressed in many cell types, including osteoblasts and osteoclasts, is emerging as a key regulator of bone mass and strength. STAT3 mutations cause a rare human immunodeficiency disease characterized by extremely elevated levels of IgE in serum that have associated craniofacial and skeletal features, such as reduced bone mineral density and recurrent pathological fractures. Our microarray data and immunohistochemical staining using a normal rat mode

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Hedges, Christopher. "The effects of physiological acidosis on skeletal muscle mitochondrial function, ROS balance, and intracellular signalling." Thesis, 2017. https://vuir.vu.edu.au/35976/.

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Abstract (sommario):

Mitochondrial adaptation in skeletal muscle is promoted by a diverse array of stimuli, and changes in mitochondrial plasticity have been noted as a result of a many exercise modalities. High-intensity interval training is one such modality that promotes mitochondrial adaptation in response to repeated short-duration bouts of intense effort. Another result of intense muscular effort is a decrease in muscle pH, resulting in intracellular acidosis. The effect of this acidosis on oxygen consumption in muscle has received attention previously, with mixed findings. An aspect of skeletal muscle mitoc

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