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Tesi sul tema "Antibody affinity"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 14 febbraio 2022

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1

Low, Nigel Murray. "Mimicking antibody affinity maturation." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364567.

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2

Molari, Marco. "Modeling and Bayesian inference for antibody affinity maturation." Thesis, Université Paris sciences et lettres, 2020. http://www.theses.fr/2020UPSLE017.

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La Maturation d’Affinité (MA) est le processus biologique grâce auquel notre système immunitaire génère de puissants anticorps contre les nouveaux agents pathogènes rencontrés. Ce processus est également à la base de la vaccination, l’une des procédures médicales les plus efficaces jamais mises au point, qui permet de sauver des millions de vies chaque année. La MA présentent encore de nombreuses questions ouvertes, dont les réponses peuvent améliorer la manière dont nous vaccinons. Les mécanismes à la base de la MA sont extrêmement complexes, avec des interactions non linéaires entre nombreux

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3

Lang, Birthe Agnetha. "Nanofibrous affinity membranes containing non-antibody binding proteins." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15326/.

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The specific removal of molecules from various media is an area receiving increasing attention. Affnity membranes, i.e. membranes containing ligands, which can specifically capture target molecules, can meet this demand. One important area, in which the use of affinity membranes will be beneficial, is blood filtration, specifically haemodialysis treatments. The specific removal of toxins can reduce treatment time and/or frequency and therefore increase patients' quality of life as well as reduce costs for the health care sector. The presented research investigates the feasibility of combining

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4

Attiya, Said. "Antibody labeling methods for automated affinity electrophoresis on microchips." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0010/NQ59926.pdf.

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5

Hey, Carolyn McKenzie. "Antibody Purification from Tobacco by Protein A Affinity Chromatography." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/42645.

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Antibodies represent the largest group of biopharmaceuticals. Due to the nature of their clinical applications, they often need to be produced in large quantities. Plants have distinct advantages of producing large quantities of recombinant proteins, and tobacco is arguably the most promising plant for plant-made-pharmaceuticals (PMP) due to its high biomass yields and robust transformation technology. However, to produce proteins using transgenic tobacco for human applications, purification of the proteins is challenging. On the other hand, Protein A, a bacterial cell wall protein isolated fr

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6

Sundberg, Mårten. "Protein microarrays for validation of affinity binders." Licentiate thesis, KTH, Proteomik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-48256.

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Is specificity an important issue regarding affinity reagents? What about the validation of affinity reagents today, is it good enough? This depends on the application and the producer of the reagent. Validation should be the most important marketing argument that can be found.Today there is a continuous growth of both the number of affinity reagents that are produced and the different types of affinity reagents that are developed. In proteomics they become more and more important in exploring the human proteome. Therefore, validated affinity reagents should be on top of every proteomic resear

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7

Qundos, Ulrika. "Antibody based plasma protein profiling." Doctoral thesis, KTH, Proteomik och nanobioteknologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-126270.

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This thesis is about protein profiling in serum and plasma using antibody suspension bead arrays for the analysis of biobanked samples and in the context of prostate cancer biomarker discovery. The influence of sample preparation methods on antibody based protein profiles were investigated (Papers I-III) and a prostate cancer candidate biomarker identified and verified (Papers III-V). Furthermore, a perspective on the research area affinity proteomics and its’ employment in biomarker discovery, for improved understanding and potentially improved disease diagnosis, is provided. Paper I presents

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8

Ye, Jianmin. "The relationship between antibody redox structure and affinity in rainbow trout." W&M ScholarWorks, 2008. https://scholarworks.wm.edu/etd/1539616918.

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Teleost immunoglobulin M (IgM), an 800 kDa tetramer, possesses considerable structural diversity due to the non-uniform disulfide polymerization of its halfmeric or monomeric subunits. However, to date, no plausible functional role for this diversity has been demonstrated or proposed. This research was, therefore, designed to investigate the possible functional role(s) for this diversity using the trout model. The possible relationship between this structural diversity and affinity was specifically addressed. The relationship between high levels of disulfide polymerization and high affinity wa

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9

Midelfort, Katarina Senn. "Biophysical characterization of high affinity engineered single chain Fv antibody fragments." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/30051.

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Thesis (Ph. D. in Molecular Systems Toxicology and Pharmacology)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.<br>Vita.<br>Includes bibliographical references.<br>High affinity antibody binding interactions are important for both pharmaceutical and biotechnological uses. However, designing higher affinity interactions has remained difficult. Both high affinity interactions from nature and the results from directed evolution affinity maturation processes may yield clues about the important structural and energetic contributions to attain these tight associations

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10

Fernandes, Telma Godinho Barroso Maciel. "Functional monolithic platforms for antibody purification." Doctoral thesis, Faculdade de Ciências e Tecnologia, 2014. http://hdl.handle.net/10362/11550.

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Dissertação para obtenção do Grau de Doutor em Química Sustentável<br>Fundação para a Ciência e Tecnologia - contracts PEst-C/EQB/LA0006/2011, MIT-Pt/BS-CTRM/0051/2008, PTDC/EBB-BIO/102163/2008, PTDC/EBBBIO/ 098961/2008, PTDC/EBB-BIO/118317/2010 and doctoral grant SFRH/ BD/62475/2009, and Fundação Calouste Gulbenkian

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11

Marillet, Simon. "Modélisation de la réponse des anticorps : de la structure des complexes immunoglobuline - antigène à la complexité clonale des répertoires de chaines lourdes d'immunoglobulines." Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4120/document.

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Cette thèse étudie trois sujets relevant de la biologie structurale, de lagénétique et de l'immunologie.Premièrement, nous développons de nouveaux prédicteurs de l'affinité deliaison de complexes protéiques, produisant des résultats de niveau ``état del'art''. Nous calculons d'abord 12 variables modélisant diverses propriétésstructurales des complexes. Nous générons et évaluons des estimateursutilisant des sous ensembles de ces variables, de façon à identifier les plusperformants. Le logiciel associé est distribué dans la Structural BioinformaticsLibrary.Deuxièmement, nous proposons de nouvell

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12

Fong, Robin B. "Affinity bioseparations with smart polymer conjugates containing DNA, streptavidin, and antibody fragments /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/8071.

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13

Skamaki, Kalliopi. "In vitro evolution of antibody affinity using libraries with insertions and deletions." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/286439.

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In Nature, antibodies are capable of recognizing a huge variety of different molecular structures on the surface of antigens. The primary factor that defines the structural diversity of the antibody antigen combining site is the length variation of the complementarity determining region (CDR) loops. Following antigen stimulation, further diversification through the process called somatic hypermutation (SHM) leads to antibodies with improved affinity and specificity. Sequence diversification by SHM is mainly achieved by introduction of point substitutions and a small percentage of insertions/de

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14

Karlsson, Mikael. "Determination of antibody affinity and kinetic binding constants in Gyrolab Bioaffy microfluidic CD." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11616.

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<p>Studies of binding reactions are of highest importance in a vast number of areas of biomedicine and biotechnology. A demand for fast and accurate small-volume measurements grows stronger, partly due to the development of therapeutic antibodies. In this report, a novel method for studies of binding reactions of antibodies is described. The use of a microfluidic platform shows promising results in determination of affinity binding constants.</p><p>Affinities between 1E-09 and 1E-11 M have been determined for four TSH antibodies. Reproducibility tests give a CV below 10%, using different Gyrol

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15

Zhang, Haili. "Functional and Molecular Analysis of Antibody Affinity Maturation in Rainbow Trout (Oncorhynchus mykiss)." W&M ScholarWorks, 1999. https://scholarworks.wm.edu/etd/1539617980.

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16

陳磊碩 and Lui-sek Chan. "Chemical modification of immunoglobulins and the effects on antigen binding site affinity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B29913378.

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17

Chan, Lui-sek. "Chemical modification of immunoglobulins and the effects on antigen binding site affinity /." [Hong Kong] : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13731506.

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18

Falk, Ronny. "Systems enabling antibody-mediated proteomics research." Doctoral thesis, Stockholm, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4025.

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19

Berglund, Lisa. "Selection of antigens for antibody-based proteomics." Doctoral thesis, Stockholm : School of Biotechnology, Royal Institute of Technology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4706.

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20

Sundberg, Mårten. "Mass Spectrometry and Affinity Based Methods for Analysis of Proteins and Proteomes." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259623.

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Abstract (sommario):

Proteomics is a fast growing field and there has been a tremendous increase of knowledge the last two decades. Mass spectrometry is the most used method for analysis of complex protein samples. It can be used both in large scale discovery studies as well as in targeted quantitative studies. In parallel with the fast improvements of mass spectrometry-based proteomics there has been a fast growth of affinity-based methods. A common challenge is the large dynamic range of protein concentrations in biological samples. No method can today cover the whole dynamic range. If affinity and mass spectrom

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21

Lippow, Shaun Matthew. "Computational analysis, design, and experimental validation of antibody binding affinity improvements beyond in vivo maturation." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/38886.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2007.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references (leaves 98-110).<br>This thesis presents novel methods for the analysis and design of high-affinity protein interactions using a combination of high-resolution structural data and physics-based molecular models. First, computational analysis was used to investigate the molecular basis for the affinity improvement of

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22

Thomas, Roula. "The effect of point mutations on the binding affinity of anti-blood group A antibody AC1001." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0021/MQ48186.pdf.

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23

Swers, Jeffrey Seth. "Isolation and engineering of a high affinity antibody against P-selectin glycoprotein ligand-1 (PSGL-1)." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32323.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.<br>Vita.<br>Includes bibliographical references (leaves 87-91).<br>We aim to develop novel protein antagonists of P-selectin adhesion as anti- inflammatory therapeutics. Blocking P-selectin adhesion is particularly attractive because this adhesion mediates leukocyte rolling which occurs early in the inflammatory cascade before extensive tissue damage caused by the amplification of inflammation by proinflammatory cytokines. Currently, no subnanomolar antagonists of selectin adhesion are available. The l

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24

Conti, Sofia Alessandra. "Monoclonal antibodies purification via Protein G and protein A affinity chromatography." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.

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Abstract (sommario):

realization of a pilot scale affinity protein G chromatography for the purification of small volumes of supernatant from different harvests from the same antibody clone. The objective was to make a study on the productivity of each harvest, investigating for a dilution effect in case of an increasing number of harvests, and to have a rapid retention kit for the quality control of the purified antibody. Moreover, an identical column packed with protein A has been tested with the same products, in order to see if there was space for a yield improvement, and a further scale-up.

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25

Newman, Peter Michael Pathology UNSW. "Antibody and Antigen in Heparin-Induced Thrombocytopenia." Awarded by:University of New South Wales. Pathology, 2000. http://handle.unsw.edu.au/1959.4/17485.

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Immune heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin therapy and is associated with antibodies directed against a complex of platelet factor 4 (PF4) and heparin. Early diagnosis of HIT is important to reduce morbidity and mortality. I developed an enzyme immunoassay that detects the binding of HIT IgG to PF4-heparin in the fluid phase. This required techniques to purify and biotinylate PF4. The fluid phase assay produces consistently low background and can detect low levels of anti-PF4-heparin. It is suited to testing alternative anticoagulants because

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26

Hjelm, Linnea. "Selection of affibody and domain antibody binders to the Binding Region (BR) domain of theadhesion protein PsrP of Streptococcus pneumoniae." Thesis, KTH, Skolan för bioteknologi (BIO), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215246.

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27

Canelle, Quentin. "Real Time Surface Plasmon Resonance Biosensors, a Powerful Technology to Assess Polyclonal Antibody Avidity." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/216754.

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The present research focused on the development of a new methodology to assess the strength of the interaction between vaccine antigens and elicited polyclonal antibodies through SPR biosensors. Quantifying the binding strength of polyclonal antibodies is of first importance to evaluate the quality of the vaccine as well as to increase the scientific knowledge of immune protection mechanisms. To now the development of such tool has been complicated by the non-specific binding caused by high protein abundance in the blood and serum samples but also by the way of interpreting the data resulting

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28

Zielonka, Stefan [Verfasser], Harald [Akademischer Betreuer] Kolmar, Stefan [Akademischer Betreuer] Dübel, and Florian [Akademischer Betreuer] Rüker. "The shark strikes twice: Generation of Mono- and Bispecific High-Affinity vNAR Antibody Domains via Step-Wise Affinity Maturation / Stefan Zielonka. Betreuer: Harald Kolmar ; Stefan Dübel ; Florian Rüker." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2015. http://d-nb.info/1111112983/34.

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29

Cui, Yalun. "Design, Development, and Production of Therapeutic Immunoglobulins for Inhibition of Carboxyethylpyrrole-Induced Angiogenesis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1386090936.

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30

Byström, Sanna. "Affinity assays for profiling disease-associated proteins in human plasma." Doctoral thesis, KTH, Proteomik och nanobioteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-202616.

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Affinity-based proteomics offers opportunities for the discovery and validation of disease-associated proteins in human body fluids. This thesis describes the use of antibody-based immunoassays for multiplexed analysis of proteins in human plasma, serum and cerebrospinal fluid (CSF). This high-throughput method was applied with the objective to identify proteins associated to clinical variables. The main work in this thesis was conducted within the diseases of multiple sclerosis and malignant melanoma, as well as mammographic density, a risk factor for breast cancer. The suspension bead array

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31

Zuo, Ziwei. "Development of an Optical Fiber Biosensor with Nanoscale Self-Assembled Affinity Layer." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/54590.

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Optical sensor systems that integrate Long-Period-Gratings (LPG) as the detection arm have been proven to be highly sensitive and reliable in many applications. With increasing public recognition of threats from bacteria-induced diseases and their potential outbreak among densely populated communities, an intrinsic, low-cost biosensor device that can perform quick and precise identification of the infection type is in high demand to respond to such challenging situations and control the damage those diseases could possibly cause. This dissertation describes the development of a biosensor pl

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32

Gibbs, Ebrima. "Evolution of the anti-interferon beta (IFNβ) antibody response in multiple sclerosis patients : IgG subclass distribution, affinity maturation and clinical correlates". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5281.

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Multiple Sclerosis (MS), a chronic degenerative disease of the central nervous system, is characterized by demyelination, axonal damage, and inflammatory lesions in the white matter. Symptoms include neurological deficits, relapses and progressive disability. Three recombinant interferon beta (IFNβ) products and glatiramer acetate are licensed for treatment. They have been shown to reduce the frequency and severity of relapses and slow disease progression in about 30% of treated patients. Long-term administration of IFNβ can result in the development of anti- (IFNβ) antibodies. Binding antibod

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33

Poma, Alessandro. "Automatic solid-phase synthesis of molecularly imprinted nanoparticles (MIP NPs)." Thesis, Cranfield University, 2012. http://dspace.lib.cranfield.ac.uk/handle/1826/7911.

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Molecularly Imprinted Polymers (MIPs) are potential generic alternatives to antibodies in diagnostics and separations. To compete with biomolecules in these technological niches, MIPs need to share the characteristics of antibodies (solubility, size, specificity and affinity) whilst maintaining the advantages of MIPs (low cost, short development time and high stability). For this reason the interest in preparing MIPs as nanoparticles (MIP NPs) has increased exponentially in the last decade. Cont/d.

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34

Hu, Francis Jingxin. "Utilizing Solid Phase Cloning, Surface Display And Epitope Information for Antibody Generation and Characterization." Doctoral thesis, KTH, Proteomik och nanobioteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-205410.

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Antibodies have become indispensable tools in diagnostics, research and as therapeutics. There are several strategies to generate monoclonal antibodies (mAbs) in order to avoid the drawbacks of polyclonal antibodies (pAbs) for therapeutic use. Moreover, the growing interest in precision medicine requires a well-characterized target and antibody to predict the responsiveness of a treatment. This thesis describes the use of epitope information and display technologies to generate and characterize antibodies. In Paper I, we evaluated if the epitope information of a well-characterized pAb could be

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35

Silva, Ivani Jose da. "Avidez de IgG na Toxoplasmose: padronização do pH como caotrópico para quantificação direta de anticorpos de baixa avidez." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-27092011-110151/.

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A toxoplasmose é uma protozoose altamente prevalente que atinge pelo menos um bilhão de indivíduos no mundo. A infecção causada pelo Toxoplasma gondii é benigna e assintomática, mas pode causar perdas visuais ou morte em fetos e pacientes imunossuprimidos. Isto pode ser controlado com diagnóstico e instituição de tratamento, mas depende da determinação de infecção ativa ou recente. O diagnóstico parasitológico é complexo, demorado e só executado em poucos centros, sendo a sorologia específica essencial no diagnóstico da doença. A avidez de anticorpos IgG tem sido utilizada para determinação da

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36

Otani, Yuki. "Time-dependent structural alteration of rituximab analyzed by LC/TOF-MS after a systemic administration to rats." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225506.

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37

Lundberg, Emma. "Bioimaging for analysis of protein expression in cells and tissues using affinity reagents." Doctoral thesis, Stockholm : School of biotechnology, Royal institute of technology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4862.

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38

Mohseni, Nodehi Sahar [Verfasser]. "Improved Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) of Affinity Maturated and Fc-Engineered Antibodies Directed Against the AML Stem Cell Antigen CD96 / Sahar Mohseni Nodehi." Kiel : Universitätsbibliothek Kiel, 2011. http://d-nb.info/1033824208/34.

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39

D'Souza, Vijay Kenneth. "Pharmacological and molecular characterisation of P2Y receptors in endothelial and epithelial cells." Thesis, University of Wolverhampton, 2007. http://hdl.handle.net/2436/20512.

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In light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic the third extracellular loop of the human P2Y2 receptor, the aim of this study was to use this peptide as an immunogen to generate and fully characterise polyclonal rabbit antibodies to the P2Y2 receptor. Other aims of this study were to characterise epithelial and endothelial cells for a thorough expression profile of P2Y receptor mRNA transcripts in order to provide a rapid screen for the molecular determinants of these receptors in these cells. These studies also ai

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40

Neiman, Maja. "Bead based protein profiling in blood." Doctoral thesis, KTH, Proteomik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-117960.

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This thesis is about protein profiling in blood-derived samples using suspension bead ar- rays built with protein affinity reagents, and the evaluation of binding characteristics and potential disease relation of such profiles. A central aim of the presented work was to discover and verify disease associated protein profiles in blood-derived samples such as serum or plasma. This was based on immobiliz- ing antigens or antibodies on color-coded beads for a multiplexed analysis. This concept generally allow for a dual multiplexing because hundreds of samples can be screened for hundreds of prote

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41

Silva, Sandriana dos Ramos. "Estudo comparativo da região Fc de anticorpos IgG1 murinos anafiláticos e não-anafiláticos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-19052010-134913/.

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Está estabelecido que o processo de glicosilação é essencial para a conformação estrutural e função efetora dos anticorpos. Entretanto, não está completamente claro como diferenças nos carboidratos ligados aos anticorpos podem interferir na sua atividade biológica. Foi previamente descrito que anticorpos IgG1 murinos podem ser divididos em anafiláticos ou não-anafiláticos, de acordo com a sua capacidade de induzir in vivo reação de anafilaxia. Somado a isso, foi verificado que a cadeia de oligossacarídeos N-ligada à molécula de IgG1 é fundamental para a manutenção da sua função efetora. O obje

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42

Su, Dan. "Rational design, characterization and in vivo studies of antibody mimics against HER2." Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/133.

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Human Epidermal Growth Factor Receptor 2 (HER2) is a cell surface receptor tyrosine kinase and plays a role in the signal pathways leading to cell proliferation and differentiation. Overexpression of HER2 is found in various cancers including breast, ovarian, gastric, colon, and non-small-cell lung cancers, which makes it an attractive target for cancer therapy. Specific antibodies, peptides and small molecules are developed by scientists to bind with HER2 as therapeutical agents, dimerization inhibitors and biological makers. Among these molecules, antibodies showed excellent binding affinity

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43

Brown, Elizabeth L. "Consequences of genital herpes simplex virus infection among vulnerable populations /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/10885.

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44

Drobin, Kimi. "Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum." Licentiate thesis, KTH, Proteinvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-225980.

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Affinity-based proteomics utilizes affinity binders to detect target proteins in a large-scale manner. This thesis describes a high-throughput method, which enables the search for biomarker candidates in human plasma and serum. A highly multiplexed antibody-based suspension bead array is created by coupling antibodies generated in the Human Protein Atlas project to color-coded beads. The beads are combined for parallel analysis of up to 384 analytes in patient and control samples. This provides data to compare protein levels from the different groups. In paper I osteoporosis patients are compa

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45

Troiano, Claudia. "Caratterizzazione di membrane per la purificazione di anticorpi." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/12532/.

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Negli ultimi decenni l'utilizzo delle biotecnologie e delle tecniche di DNA ricombinante hanno portato allo sviluppo di farmaci a base di anticorpi monoclonali efficaci nella cura di varie malattie. Lo stadio principale del processo di purificazione impiegato a livello industriale è la cromatografia di affinità con proteina A, ma le operazioni di purificazione comprendono anche altri stadi cromatografici. Molti studi sono mirati alla ricerca di alternative più economiche al processo convenzionale con il ligando naturale per le IgG: è in questo contesto che si inserisce la tesi di laurea. Si ce

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46

Cedergren, Linda. "Expression of recombinant protein including an His-tag to facilitate purification for diagnosis of CCHF and Lassa Viruses." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7064.

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<p>Abstract</p><p>Crimean-Congo Hemorrhagic Fever virus (CCHF) and Lassa virus are giving sources illness to humans. In addition to zoonotic transmission, CCHF and Lassa virus can spread from person to person. After a short incubation period, CCHF and Lassa virus infections are characterized by a sudden onset of high fever, chills, headache and cough just like flu. Even some people are vomiting and have diarrhoea. After a few days of illness hemorrhagic manifestations occur. Treatment options for CCHF and Lassa viruses are limited, and there is no vaccine available for use in humans. The purpo

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47

Gargouri, Dorra. "Synthèse de réactifs multifonctionnels et d'analogues de mycotoxine. Application à la détection de mycotoxines dans des solutions alimentaires." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMR041.

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Les mycotoxines sont des métabolites secondaires développées par différentes espèces de champignons. Elles sont présentes dans l’environnement et peuvent entrer dans la chaîne alimentaire, et provoquer des intoxications graves. De ce fait, des doses tolérables pour chaque mycotoxine ont été fixées par l’Organisation Mondiale de Santé. Une quantité infime de ces toxines peut contaminer l’ensemble de la chaîne alimentaire, il est donc nécessaire de mettre au point des méthodes de détection fines et sensibles des toxines résiduelles. Il existe des techniques de laboratoire longues et coûteuses po

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48

Boström, Tove. "High-throughput protein analysis using mass spectrometry-based methods." Doctoral thesis, KTH, Proteinteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-154513.

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In the field of proteomics, proteins are analyzed and quantified in high numbers. Protein analysis is of great importance and can for example generate information regarding protein function and involvement in disease. Different strategies for protein analysis and quan- tification have emerged, suitable for different applications. The focus of this thesis lies on protein identification and quantification using different setups and method development has a central role in all included papers. The presented research can be divided into three parts. Part one describes the develop- ment of two diff

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49

Weiser, Armin. "Amino acid substitutions in protein binding." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15962.

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Die Modifizierung von Proteinsequenzen unter anderem durch den Austausch von Aminosäuren ist ein zentraler Aspekt in evolutionären Prozessen. Solche Prozesse ereignen sich nicht nur innerhalb großer Zeiträume und resultieren in der Vielfalt des Lebens, das uns umgibt, sondern sind auch täglich beobachtbar. Diese mikroevolutionären Prozesse bilden eine Grundlage zur Immunabwehr höherer Wirbeltiere und werden durch das humorale Immunsystem organisiert. Im Zuge einer Immunantwort werden Antikörper wiederholt der Diversifizierung durch somatische Hypermutation unterworfen. Ziele dieser Arbeit ware

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50

Kirchgatter, Karin. "Plasmodium vivax: Caracterização Molecular de Recaídas Utilizando um Segmento Polimórfico do Gene MSP1 como Marcador Genético." Universidade de São Paulo, 1997. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-01102004-140121/.

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Plasmodium vivax é a espécie de malária humana de maior distribuição geográfica, com 35 milhões de casos por ano. No Brasil, é a espécie mais prevalente, sendo responsável por cerca de 70% dos casos de malária. Diferentemente do P. falciparum, o P. vivax apresenta hipnozoítas, formas que se mantêm em estágio dormente no fígado e que, após um período de tempo variável, por mecanismos ainda desconhecidos, causam novo ataque malárico denominado recaída. Para contribuir para um melhor conhecimento acerca das recaídas causadas por P. vivax, neste trabalho foram analisadas amostras pareadas referent

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