Letteratura scientifica selezionata sul tema "Biophysical screening"
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Articoli di riviste sul tema "Biophysical screening"
Genick, Christine Clougherty, Danielle Barlier, Dominique Monna, Reto Brunner, Céline Bé, Clemens Scheufler e Johannes Ottl. "Applications of Biophysics in High-Throughput Screening Hit Validation". Journal of Biomolecular Screening 19, n. 5 (2 aprile 2014): 707–14. http://dx.doi.org/10.1177/1087057114529462.
Testo completoLinke, Pawel, Kwame Amaning, Melanie Maschberger, Francois Vallee, Valerie Steier, Philipp Baaske, Stefan Duhr, Dennis Breitsprecher e Alexey Rak. "An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery". Journal of Biomolecular Screening 21, n. 4 (2 dicembre 2015): 414–21. http://dx.doi.org/10.1177/1087057115618347.
Testo completoKamel, Hassan S., Ahmed M. Makhlouf e Alaaeldin A. Youssef. "Simplified Biophysical Profile: An Antepartum Fetal Screening Test". Gynecologic and Obstetric Investigation 47, n. 4 (1999): 223–28. http://dx.doi.org/10.1159/000010110.
Testo completoRenaud, Jean-Paul, e Marc-André Delsuc. "Biophysical techniques for ligand screening and drug design". Current Opinion in Pharmacology 9, n. 5 (ottobre 2009): 622–28. http://dx.doi.org/10.1016/j.coph.2009.06.008.
Testo completoPatil, Devashree N., Sushama A. Patil, Srinivas Sistla e Jyoti P. Jadhav. "Comparative biophysical characterization: A screening tool for acetylcholinesterase inhibitors". PLOS ONE 14, n. 5 (31 maggio 2019): e0215291. http://dx.doi.org/10.1371/journal.pone.0215291.
Testo completoMurphy, Samuel L., Anand Bhagwat, Shyrie Edmonson, Shangzhen Zhou e Katherine A. High. "High-throughput Screening and Biophysical Interrogation of Hepatotropic AAV". Molecular Therapy 16, n. 12 (dicembre 2008): 1960–67. http://dx.doi.org/10.1038/mt.2008.210.
Testo completoHuang, Renjie, Daniel M. Ayine-Tora, M. Nasri Muhammad Rosdi, Yu Li, Jóhannes Reynisson e Ivanhoe K. H. Leung. "Virtual screening and biophysical studies lead to HSP90 inhibitors". Bioorganic & Medicinal Chemistry Letters 27, n. 2 (gennaio 2017): 277–81. http://dx.doi.org/10.1016/j.bmcl.2016.11.059.
Testo completoGhodsvali, Alireza, Vahid Farzaneh, Hamid Bakhshabadi, Zahra Zare, Zahra Karami, Mohsen Mokhtarian e Isabel S. Carvalho. "Screening of the aerodynamic and biophysical properties of barley malt". International Agrophysics 30, n. 4 (1 ottobre 2016): 457–64. http://dx.doi.org/10.1515/intag-2016-0017.
Testo completoAFZAL, AYSHA, e KHALIDA NASREEN. "BIOPHYSICAL SCORE". Professional Medical Journal 13, n. 03 (25 giugno 2006): 362–69. http://dx.doi.org/10.29309/tpmj/2006.13.03.4983.
Testo completoSantoso, Aline T., Xiaoyan Deng, Jeong-Hyun Lee, Kerryn Matthews, Simon P. Duffy, Emel Islamzada, Sarah M. McFaul, Marie-Eve Myrand-Lapierre e Hongshen Ma. "Microfluidic cell-phoresis enabling high-throughput analysis of red blood cell deformability and biophysical screening of antimalarial drugs". Lab on a Chip 15, n. 23 (2015): 4451–60. http://dx.doi.org/10.1039/c5lc00945f.
Testo completoTesi sul tema "Biophysical screening"
Wang, Shao-Fang. "Biochemical and biophysical studies of MDM2-ligand interactions". Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9527.
Testo completoBrown, Christopher John. "Structure-based design of anti-cancer drugs : the use of biophysical techniques for screening and characterization of novel inhibitors of the initiation factor eIF4E". Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/15435.
Testo completoMenchon, Grégory. "Criblage virtuel et fonctionnel sur le complexe XRCC4/ADN ligase IV/Cer-XLF de ligature des cassures double-brin de l'ADN : application en radiosensibilisation tumorale". Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30395.
Testo completoRadiotherapy is a major weapon used against cancer. Radio-induced DNA double strand breaks (DSB) are the main lesions responsible for cell death. Non-homologous end-joining (NHEJ) is a predominant DSB repair mechanism which contributes to cancer cells resistance to radiotherapy. NHEJ is thus a good target for strategies which aim at increasing the radio-sensitivity of tumors. Through in silico screening and biophysical and biochemical assays, our objective was to find specific ligands for the XRCC4/Lig4 and XRCC4/Cer-XLF protein-protein interactions involved in NHEJ. Here, we isolated the first compounds able to prevent their interaction in vitro. These early stage inhibitors are promising tools for cancer therapy with the hope to develop more specific compounds for cellular assays through the 3D structure of the protein/inhibitor complexes
Wilde, Lisa M. "Scanning probe and micropatterning approaches for biomolecular screening applications". Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272739.
Testo completoThalhammer, Armin. "Functional and inhibition studies on 2-oxoglutarate-dependent oxygenases". Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:41c3f967-0dd2-47dd-8dd4-bc543b626221.
Testo completoParra, Katherine Cristina. "Combination of the Computational Methods: Molecular dynamics, Homology Modeling and Docking to Design Novel Inhibitors and study Structural Changes in Target Proteins for Current Diseases". Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5093.
Testo completoThorman, Alexander W. "Rational Design of Novel BCL2A1 Inhibitors for Treatment of Autoimmune Diseases: An Integration of Virtual Screening, Transcriptomics and Protein Biophysics". University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543580409766192.
Testo completoEichelbaum, Steven Ross. "Screening of Plants for Antibacterial Properties: Growth Inhibition of Staphylococcus aureus by Artemisia Tridentata". FIU Digital Commons, 2016. https://digitalcommons.fiu.edu/etd/3526.
Testo completoPabrai, Natasha Uday. "The Use of Anti-CD3 Treatment and Genetic Screening to Delay Further Beta Cell Destruction in Type 1 Diabetes". Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/284.
Testo completoWang, Ling. "Microchannel enhanced neuron-computer interface: design, fabrication, biophysics of signal generation, signal strength optimization, and its applications to ion-channel screening and basic neuroscience research". Doctoral thesis, Universitat Politècnica de Catalunya, 2011. http://hdl.handle.net/10803/52810.
Testo completoIn this present work, we used microfabrication techniques, numerical simulations, electrophysiological experiments to explore the feasibility of enhancing neuron-computer interfaces with microchannels and the biophysics of the signal generation in microchannel devices. We also demonstrate the microchannel can be used as a promising technique for high-throughput automatic ion-channel screening at subcellular level. Finally, a microwell-microchannel enhanced multielectrode array allowing high signal-to-noise ratio (SNR), multi-site recording from the low-density hippocampal neural network in vitro was designed, fabricated and tested. First, we demonstrate using microchannels as a low-cost neuron-electrode interface to support low-complexity, long-term-stable, high SNR extracellular recording of neural activity, with high-throughput potential. Next, the biophysics of the signal generation of microchannel devices was studied by experiments and numerical simulations. Based on the results, we demonstrate and rationalize how channels with a length of 200 μm and channel cross section of 12 μm2 yielded spike sizes in the millivolt range. Despite the low degree of complexity involved in their fabrication and use, microchannel devices provided a single-unit mean SNR of 101 76, which compares favourably with the SNR obtained from recent developments employing CNT-coated electrodes and Si-NWFETs. Moreover, we further demonstrate that the microchannel is a promising technique for high-throughput automatic ion-channel screening at subcellular level: (1) Experimental data and numerical simulations suggest that the recorded signals are only affected by the membrane patches located inside the microchannel or within 100 μm to the microchannel entrances. (2) The mass transfer of chemical compounds in microchannels was analyzed by experiments and FEM simulations. The results show that the microchannel threaded by glial and neural tissue can function as fluid/chemical barrier. Thus chemical compounds can be applied to different subcellular compartments exclusively. Finally, a microwell-microchannel enhanced MEA (MWMC-MEA), with the optimal channel length of 0.3 mm and the optimal intrachannel electrode position of 0.1 mm to the nearest channel entrance, was proposed based on numerical simulation and experiment results. We fabricated a prototype of the MWMCMEA, whose through-hole feature of Polydimethylsiloxane film (PDMS) was micromachined by reactive-ion etching. The low-density culture (57 neurons/mm2) were survived on the MWMC-MEAs for at least 14 days, from which the neuronal signal with the maximum SNR of 142 was obtained.
Capitoli di libri sul tema "Biophysical screening"
Williams, Glyn. "The Pyramid™ Approach to Fragment-Based Biophysical Screening". In Label-Free Technologies for Drug Discovery, 241–53. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470979129.ch16.
Testo completoCiulli, Alessio. "Biophysical Screening for the Discovery of Small-Molecule Ligands". In Protein-Ligand Interactions, 357–88. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-398-5_13.
Testo completoPark, Hyun-Ju, e So-Jung Park. "Virtual Screening for RNA-Interacting Small Molecules". In Biophysical approaches to translational control of gene expression, 235–52. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3991-2_12.
Testo completoBhunia, Shome S., Mridula Saxena e Anil K. Saxena. "Ligand- and Structure-Based Virtual Screening in Drug Discovery". In Biophysical and Computational Tools in Drug Discovery, 281–339. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/7355_2021_130.
Testo completoScott, Duncan E., Christina Spry e Chris Abell. "Differential Scanning Fluorimetry as Part of a Biophysical Screening Cascade". In Fragment-based Drug Discovery Lessons and Outlook, 139–72. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527683604.ch07.
Testo completoFasolato, Claudia. "SERS-Active Nanovectors for Single-Cell Cancer Screening and Theranostics". In Surface Enhanced Raman Spectroscopy for Biophysical Applications, 113–35. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-03556-3_5.
Testo completoHennig, Michael, Armin Ruf e Walter Huber. "Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery". In Topics in Current Chemistry, 115–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/128_2011_225.
Testo completoPant, Pradeep, e B. Jayaram. "A Rapid Computational Screening of Millions of Molecules to Identify Sequence-Specific DNA Minor Groove Binders via Physicochemical Descriptors". In Biophysical and Computational Tools in Drug Discovery, 341–67. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/7355_2021_122.
Testo completoNarayan, Kartik, e Steven S. Carroll. "SPR Screening". In Applied Biophysics for Drug Discovery, 93–105. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119099512.ch6.
Testo completoSolovchenko, Alexei. "Screening Pigments: General Questions". In Springer Series in Biophysics, 9–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13887-4_2.
Testo completoAtti di convegni sul tema "Biophysical screening"
Roshan, Saboora M., e Edward J. Park. "Impairment Screening Utilizing Biophysical Measurements and Machine Learning Algorithms". In 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2021. http://dx.doi.org/10.1109/embc46164.2021.9630022.
Testo completoAmato, Jussara, Simona Marzano, Bruno Pagano, Nunzia Iaccarino, Anna Di Porzio, Stefano De Tito, Eleonora Vertecchi, Erica Salvati e Antonio Randazzo. "Targeting of telomeric repeat-containing RNA G-quadruplexes: From screening to biophysical and biological characterization of a new hit compound". In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11382.
Testo completoSchmitz, Rebecca, Alex J. Walsh, Kelsey Tweed, Steven Trier, Anna Huttenlocher e Melissa Skala. "Zebrafish xenograft breast cancer models for high-throughput drug response screening". In Biophysics, Biology and Biophotonics IV: the Crossroads, a cura di Adam Wax e Vadim Backman. SPIE, 2019. http://dx.doi.org/10.1117/12.2513688.
Testo completoTan, Qiyan, Weichuan Guo, Gutian Zhao, Yajing Kan, Yinghua Qiu e Yunfei Chen. "Charge Inversion of Mica Surface in Multivalent Electrolytes". In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-62356.
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