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Articoli di riviste sul tema "Blood disorder"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Dua, Dr Rohini, Dr Sanjana Arora, and Dr Heena Rani. "BLEEDING DISORDER." International Journal of Advanced Research 12, no. 09 (2024): 426–40. http://dx.doi.org/10.21474/ijar01/19472.

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Blood is a form of connective tissue made up of two main components: Red blood cells, white blood cells, and platelets make up the fluid which is known as plasma and a cellular component. Disorders related to blood and bone marrow fall under hematopoietic system disorders. Bleeding disorders are conditions where blood does not clot correctly. Normally, platelets clump together to create a plug at the location of a blood vessel injury. Clotting factors, which are proteins found in the blood, collaborate to form a fibrin clot. This clot holds the platelets in place, assists with healing, and hel

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2

Moalem, Kamilia N., Thomas J. Harrington, Maya Bloomberg, Gerald A. Soff, and Diana Marie Byrnes. "Impact of Inherited Bleeding Disorders on Peripartum Blood Loss: Insights from a Majority Hispanic Cohort Study." Blood 144, Supplement 1 (2024): 7690. https://doi.org/10.1182/blood-2024-202488.

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Introduction: According to the World Health Organization, 25% of pregnancy related deaths were due to severe bleeding occurring in the postpartum period (Khan et al. 2006). Women with inherited bleeding disorders are known to have an increased risk of bleeding complications during delivery (Leebek et al. 2020; Peyvandi et al. 2011). There is a scarcity of published data on obstetric related outcomes in women with congenital bleeding disorders in the US, and even less information on minority ethnic subgroups. Herein we provide bleeding outcomes for a cohort of patients with inherited bleeding d

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Hussein, O. Kready, Mohammed Mohammed, Salem May, and Salim Al-Karwi* Abdullah. "SCREENING AND DIAGNOSIS OF BETA-THALASSEMIA DEPENDING ON HBA2 AND BLOOD FILM IN BAGHDAD CITY." World Journal of Pharmaceutical Science and Research 2, no. 6 (2023): 91——98. https://doi.org/10.5281/zenodo.10935410.

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Background: Thalassemia is a group of inherited disorders that cause chronic anemia due to reduced or no production of hemoglobin. There are two types, α-thalassemia and β-thalassemia, based on genetic mutations and affected globin-chain subunits. Aim: This study in central Iraq aimed to increase awareness about different aspects of thalassemia and determine the prevalence, diagnosis, and trends of patients in Iraq based on blood film and HBA2%. Material and method: This retrospective study analyzed data from 53 thalassemia patients at Al-Kharama Teaching Hospital in Baghdad during

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4

Fedoseyeva, I. F., T. V. Poponnikova, and A. V. Veremeyev. "Noradrenaline state in children with a tic disorders." Bulletin of Siberian Medicine 8, no. 1(2) (2009): 87–89. http://dx.doi.org/10.20538/1682-0363-2009-1(2)-87-89.

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The content of noradrenaline in blood serum in 28 children 6–16 years of age with tic disorder was analyzed. It was detected reliable descent the content of noradrenaline in blood serum of the children with a tic disorders compared the group of healthy children. Authors suppose that metabolism of noradrenaline takes part in pathogenesis of tic disorder, emotional and behavioral disorders.

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Godara, Amandeep, Nauman Siddiqui, Zarmina Khan, Ankit Kansagra, Jean Yared, and Saurabh Dahiya. "Blood and Blues: Prevalence of Mental Health Disorders in Patients Hospitalized with Acute Leukemia." Blood 132, Supplement 1 (2018): 4871. http://dx.doi.org/10.1182/blood-2018-99-120239.

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Abstract Introduction: Approximately 1.5% of population will be diagnosed with leukemia in their lifetime (SEER Cancer Statistics Review). Diagnosis of acute leukemia has an overwhelming effect on the patient and their families. Besides the diagnosis, effect of chemotherapeutic agents and agony over the ultimate outcome can also affect emotional-behavioral wellbeing. Evolution of depression as a disorder, along the course of acute leukemia has been reported in the past (David et al Procedia Soc & Behav Sci 2014). We investigated the prevalence of mental health disorders in hospitalized pat

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6

Khan, KausarRehman. "Thalassemia: Genetically transmitted blood disorder." Acta Medica International 2, no. 2 (2015): 195. http://dx.doi.org/10.5530/ami.2015.5.7.

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7

Zonda, Tamas, and David Lester. "Blood Type and Bipolar Disorder." Perceptual and Motor Skills 95, no. 3 (2002): 988. http://dx.doi.org/10.2466/pms.2002.95.3.988.

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8

SAITO, HIDEHIKO. "Blood coagulation disorder Thrombotic tendency." Nihon Naika Gakkai Zasshi 88, no. 9 (1999): 1668–78. http://dx.doi.org/10.2169/naika.88.1668.

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9

Coghlan, Andy. "Gene therapy cures blood disorder." New Scientist 207, no. 2778 (2010): 12. http://dx.doi.org/10.1016/s0262-4079(10)62249-x.

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10

Raghavan, C., and Arup K. Banerjee. "Myelodysplasia: an awkward blood disorder." International Journal of Clinical Practice 44, no. 11 (1990): 490–94. http://dx.doi.org/10.1111/j.1742-1241.1990.tb10066.x.

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11

Mahadevia, Himil, Lisa McCamy, Yahia Mohamed, et al. "Incidence of Postoperative Venous Thromboembolism, Hemorrhage, and Infection in Patients with Bleeding Disorders after Hip and Knee Arthroplasty." Blood 142, Supplement 1 (2023): 2617. http://dx.doi.org/10.1182/blood-2023-188286.

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Introduction: Patients undergoing hip or knee arthroplasty (HA or KA) developed asymptomatic postoperative (post-op) venous thromboembolism (VTE) in around 30% of cases without any pharmacologic thromboprophylaxis (ThPPx). The use of pharmacological ThPPx after HA or KA has reduced the incidence of post-op VTE within 90 days to around 0.6-1.5%. People with bleeding disorders tend to have chronic joint damage from recurrent hemarthroses and frequently require HA or KA. This was especially true in the era before chronic factor prophylaxis. The exact risk estimate of post-op VTE in this populatio

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12

Means, Robert T. "Pure red cell aplasia." Blood 128, no. 21 (2016): 2504–9. http://dx.doi.org/10.1182/blood-2016-05-717140.

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Abstract Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Primary acquired PRCA is an autoimmune disorder that is frequently antibody-mediated. Myelodysplastic syndromes may also present with the morphologic appearance of PRCA. Secondary acquired PRCA may be associated with collagen vascular/autoimmune dis

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13

Lucey, J. V., Durval C. Costa, Gwen Adshead, et al. "Brain blood flow in anxiety disorders." British Journal of Psychiatry 171, no. 4 (1997): 346–50. http://dx.doi.org/10.1192/bjp.171.4.346.

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BackgroundWe compared regional cerebral blood flow (rCBF) in three groups of patients with DSM–III–R anxiety disorders.MethodFifteen patients with obsessive–compulsive disorder (OCD), 15 with panic disorder with agoraphobia (PA), and 16 with post-traumatic stress disorder (PTSD) and a similar group of healthy controls were assessed on brain-dedicated high-resolution SPET.ResultsMANOVA revealed significant rCBF differences between diagnostic groups (F=4.4; d.f.=3, 57; P=0.007) and between cerebral regions (F=6.4; d.f.=1, 57; P=0.01) in OCD and PTSD compared with PA and healthy controls, limited

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14

Seregin, A. A., L. P. Smirnova, E. M. Dmitrieva, S. N. Vasil’eva, A. V. Semke, and S. A. Ivanova. "Glutamate Level’s in Blood Serum of Patients with Schisophrenic Spectrum and Bipolar Affective Disorder." Psikhiatriya 18, no. 3 (2020): 22–31. http://dx.doi.org/10.30629/2618-6667-2020-18-3-22-31.

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The objective: the involvement of glutamatergic neurotransmitter systems in the pathogenesis of schizophrenic spectrum disorders and BD has been repeatedly proven. But today, there are no methods available to evaluate the glutamate metabolism in patients with mental disorders. The paper presents differences in the level of glutamate in the blood serum of patients with a schizophrenic spectrum disorder, bipolar disorder, and healthy individuals.Patients and methods: the study included 224 people. 179 patients were presented with paranoid schizophrenia, simple schizophrenia, schizotypal disorder

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15

Olaiya, Oluwaseun, Zuri Hudson, Eryn Bilynsky, Hung-Wen Yeh, and Shannon L. Carpenter. "Bleeding Disorder Referrals to Hematology Clinic: A Single Institution Experience." Blood 136, Supplement 1 (2020): 4–5. http://dx.doi.org/10.1182/blood-2020-140552.

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BACKGROUND Our tertiary care pediatric hematology/oncology/BMT service receives hundreds of referrals yearly for bleeding disorder evaluation both due to bleeding symptoms and secondary to routine preoperative laboratory testing prior to elective surgery. The evaluation for a bleeding disorder can be challenging due to the wide variability of symptoms as well as the need for accurate interpretation of lab results. In 2014, Bhasin et al., Pediatric Hematology and Oncology showed that 4% of patients referred to hematology based on a preoperative coagulation evaluation had a clinically relevant b

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16

Koraishy, Farrukh M., Joanne Salas, Thomas C. Neylan, et al. "Association of Severity of Posttraumatic Stress Disorder With Inflammation: Using Total White Blood Cell Count as a Marker." Chronic Stress 3 (January 2019): 247054701987765. http://dx.doi.org/10.1177/2470547019877651.

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Background Inflammation is known to be associated with posttraumatic stress disorder. It is not known if total white blood cell count, a routinely checked inflammatory marker, is associated with posttraumatic stress disorder symptom trajectories using medical record data. Methods We used latent class growth analysis to identify three-year posttraumatic stress disorder symptom trajectories using posttraumatic stress disorder (PTSD) Checklist (PCL) scores. The outcome for each patient was maximum white blood cell count from index posttraumatic stress disorder diagnosis to last PCL . Using linear

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17

Mohammed, Al-Momin, and Almomin Ammar. "A MATLAB model for diagnosing sickle cells and other blood abnormalities using image processing." International Journal of Electrical and Computer Engineering (IJECE) 11, no. 6 (2021): 5060–65. https://doi.org/10.11591/ijece.v11i6.pp5060-5065.

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The conventional method for detecting blood abnormality is time consuming and lacks the high level of accuracy. In this paper a MATLAB based solution has been suggested to tackle the problem of time consumption and accuracy. Three types of blood abnormality have been covered here, namely, anemia which is characterized by low count of red blood cells (RBCs), Leukemia which is depicted by increasing the number of white blood cells (WBCs), and sickle cell blood disorder which is caused by a deformation in the shape of red cells. The algorithm has been tested on different images of blood smears an

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18

Romanenko, S. Yu, K. V. Vilchevska, I. O. Bakhchivandzhi, and Yu V. Martinenko. "A rare disorder of blood coagulation." Modern pediatrics. Ukraine, no. 6(126) (October 29, 2022): 97–100. http://dx.doi.org/10.15574/sp.2022.126.97.

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The problem of impaired hemostasis remains relevant even today. Rare bleeding disorders that cause life-threatening bleeding in patient are often overlooked by clinicians. Rare blood coagulation disorders are a genetically determined group of coagulopathies caused by a deficiency of blood plasma proteins involved in hemostasis, as well as a deficiency of fibrinogen, prothrombin, blood coagulation factor V (FV), blood coagulation factors V and VIII (FV+FVIII), blood coagulation factor VII (FVII), blood coagulation factor X (FX), blood coagulation factor XI (FXI), blood coagulation factor XII (F

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19

Scully, Marie. "VITT-like disorder HITs the headlines." Blood 142, no. 26 (2023): 2229–30. http://dx.doi.org/10.1182/blood.2023022900.

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20

George, James N. "TTP: a disorder for all physicians." Blood 146, no. 2 (2025): 140–41. https://doi.org/10.1182/blood.2025029525.

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21

Rubin, Rita. "New Treatment for Rare Blood Disorder." JAMA 326, no. 23 (2021): 2354. http://dx.doi.org/10.1001/jama.2021.22226.

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22

WATANABE, AKIHARU. "Hepatic disorder caused by blood disease." Kanzo 38, no. 6 (1997): 345–48. http://dx.doi.org/10.2957/kanzo.38.345.

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23

Murphy, Michael, and Christopher Bass. "CEREBRAL BLOOD FLOW IN PANIC DISORDER." Lancet 332, no. 8618 (1988): 1027. http://dx.doi.org/10.1016/s0140-6736(88)90792-1.

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24

Elitzur, Sarah, Joanne Yacobovich, Orly Dgany, Tatyana Krasnov, Yoram Rosenbach, and Hannah Tamary. "From Blood Smear to Lipid Disorder." Journal of Pediatric Hematology/Oncology 35, no. 8 (2013): e329-e331. http://dx.doi.org/10.1097/mph.0b013e318271c915.

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25

Hvistendahl, M. "China Heads Off Deadly Blood Disorder." Science 340, no. 6133 (2013): 677–78. http://dx.doi.org/10.1126/science.340.6133.677.

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26

Vuk Pisk, S., K. Matic, E. Ivezic, N. Geres, and I. Filipcic. "comparisation of ABO blood groups between female patiens diagnosed with depressive disorders an bipolar affective disorders." European Psychiatry 65, S1 (2022): S851. http://dx.doi.org/10.1192/j.eurpsy.2022.2206.

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Introduction The prevalence of ABO alleles in population is different. Many studies confirmed the correlation between the occurrences of some diseases with different genotypes of ABO blood groups. Studies had shown possible differencese between patients with depressive dissorder and bipolar affective disorders according to ABO blood groups. There are contradictory results; some studies had shown significant association between blood group O and BAP, other showed relationship between unipolar depression and blood type O. Others shoedn association between involuntary depression and blood group A

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27

Charles, Chrystelle, Olena Bereznyakova, Gregory Jacquin, et al. "Baseline Neurological Morbidity Assessment in Adult Patients with Sickle Cell Disease : The Montreal Brain-SCD Cohort." Blood 144, Supplement 1 (2024): 521. https://doi.org/10.1182/blood-2024-203020.

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Background Individuals with sickle cell disease (SCD) are at a high risk of symptomatic stroke, vascular brain lesions, and cognitive impairment. Although these neurovascular complications are well documented in children, data in contemporary cohorts of adults remain limited. In addition, the effect of disease modifying interventions on the outcome of neurovascular complications over the lifespan are unknown. Since 2021, a multidisciplinary neurology-hematology clinic has been established at the Centre Hospitalier de l'Université de Montréal (CHUM). The primary aim of this study is to describe

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28

Shrikant, Bhanudas Ovhar. "Study on the Prevalence of Acute and Chronic Leukemia at a Tertiary Care Teaching Hospital." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 1919–27. https://doi.org/10.5281/zenodo.11208889.

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<strong>Introduction: </strong>Acute and chronic leukemia have different progression rates and cell types. It starts with genetics and radiation. Incidence is greater in certain locations and among men. Disease knowledge in specialized healthcare improves resource allocation and patient care. Blood tests, marrow aspirations, and genetic studies are needed to diagnose leukemia. Molecular abnormality-specific therapy is promising yet difficult. In a complex healthcare system, leukemia research improves therapy, diagnosis, and patient outcomes. <strong>Aim and Objectives: </strong>

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29

Halimeh, Susan, Hannelore Rott, Manuela Siebert, and Guenther Kappert. "Is a Pbac-Score a Good Tool to Quantify Menorrhagia in Women with Von Willebrand Disease and Rare Bleeding Disorders?" Blood 120, no. 21 (2012): 1133. http://dx.doi.org/10.1182/blood.v120.21.1133.1133.

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Abstract Abstract 1133 Introduction: Von Willebrand disease (VWD) is the most common inherited bleeding disorder. VWD and other autosomal inherited bleeding disorders equally affect women and men. Menorrhagia or severe menstrual bleeding (HMB) is the most common symptom of women with bleeding disorders. HMB is defined as bleeding that lasts for more than seven days or as the loss of more than 80 mL of blood per menstrual cycle. The menstrual blood loss can be quantified by the use of a pictorial bleeding assessement chart (PBAC). Samples and methods: In 195 women with menorrhagia and in 45 con

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30

Yektas, Cigdem, Ali Tufan, Onder Kilicaslan, Merve Yazici, Sumeyra Karakaya, and Enes Sarigedik. "Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder." Psychiatry and Behavioral Sciences 12, no. 3 (2022): 125. http://dx.doi.org/10.5455/pbs.20210518080022.

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Aim: the primary aim of this study was to determine whether the neutrophil / lymphocyte ratio, mean platelet volume, monocyte/ lymphocyte ratio and distribution width of red blood cells are different in children with specific learning disorders compared to healthy controls. The second aim of the study is to investigate the relationships of those inflammatory markers with SLDs clinical severity. Methods: A total of 100 drug-naive participants, aged 7-12 years, who were newly diagnosed as having specific learning disorders according to the DSM-5 criteria were compared with a healthy control grou

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31

Dominica, Dian, Silvia Naliani, Shelly Lelyana, and Ferry Sandra. "Biomarkers of Temporomandibular Disorders." SONDE (Sound of Dentistry) 3, no. 1 (2019): 41–47. http://dx.doi.org/10.28932/sod.v3i1.1782.

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Temporomandibular disorder is a disorder that includes masticatory muscles or temporomandibular joints, unbalanced joint function or both. The disorders can disturb daily activity, cause by pain. The therapy consuming time and cost. Early detection of temporomandibular disorder is needed, as a prevention of more severe disorders. Increased cortisol can be found in myofacial pain and is not found in internal dearagement or osteoarthritis. Biomarkers of interleukin and monocyte chemoattractant proteins are only found in osteoarthritis. The use of biomarkers can be useful in detecting temporomand

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32

Moiz, Bushra, and Maria Shafiq. "Transient myeloproliferative disorder." Blood 120, no. 24 (2012): 4672. http://dx.doi.org/10.1182/blood-2012-07-440917.

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Zorkina, Yana, Valeria Ushakova, Aleksandra Ochneva, et al. "Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers." Metabolites 14, no. 2 (2024): 80. http://dx.doi.org/10.3390/metabo14020080.

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Lipids are a crucial component of the human brain, serving important structural and functional roles. They are involved in cell function, myelination of neuronal projections, neurotransmission, neural plasticity, energy metabolism, and neuroinflammation. Despite their significance, the role of lipids in the development of mental disorders has not been well understood. This review focused on the potential use of lipids as blood biomarkers for common mental illnesses, such as major depressive disorder, anxiety disorders, bipolar disorder, and schizophrenia. This review also discussed the impact

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34

Nair, Arun B. "Proportion of Raised Blood Pressure and Raised Blood Sugar Level in Newly Diagnosed Attention Deficit Hyperactivity Disorder in Children." Journal of Medical Science And clinical Research 05, no. 03 (2017): 19260–66. http://dx.doi.org/10.18535/jmscr/v5i3.150.

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Serpe, Carmela, Paola De Sanctis, Marina Marini, Silvia Canaider, Provvidenza Maria Abruzzo, and Cinzia Zucchini. "Human Blood-Derived lncRNAs in Autism Spectrum Disorder." Biomolecules 15, no. 7 (2025): 937. https://doi.org/10.3390/biom15070937.

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Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder with a significant impact on public health. ASD diagnosis is based on clinical observation and typically occurs around three years of age. The identification of reliable ASD markers could facilitate early diagnosis and help pinpoint therapeutic targets for effective interventions. Long non-coding RNAs (lncRNAs), particularly those derived from blood, have been recently proposed as potential biomarkers in many pathological conditions, including neurological diseases. This manuscript summarizes original stu

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Lowe, David M. "Microbiota drives colitis in chronic granulomatous disorder." Blood 145, no. 18 (2025): 1966–67. https://doi.org/10.1182/blood.2025028350.

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Litvitskiy, P. F. "Regional blood flow and microcirculation disorders." Regional blood circulation and microcirculation 19, no. 1 (2020): 82–92. http://dx.doi.org/10.24884/1682-6655-2020-19-1-82-92.

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The lecture analyzes modern data on the types, etiology, key stages of pathogenesis, manifestations and consequences of typical forms of regional blood flow and microcirculation disorders. The lecturer dwells on typical forms of regional blood flow (in medium vessels): pathological arterial hyperemia, venous hyperemia, ischemia, and stasis. The variants of ischemia associated with increased arterial inflow to tissue or organ are considered as compared to medium-normal inflow. The lecture provides data on typical hemolymph microcirculation disorders, including intravascular, transmural, extrava

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Sembai, Helena, Sulina Yanti Wibawa, Irda Handayani, and Darmawaty ER Rauf. "The Relationship between Blood Gas Analysis Profile and the Outcome of Severe COVID-19 Patients." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 29, no. 3 (2023): 296–99. http://dx.doi.org/10.24293/ijcpml.v29i3.2017.

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Coronaviruses commonly infect the respiratory tract, leading to severe pneumonia. Respiratory problems cause numerous acid-base disorders in 2019 Coronavirus Disease (COVID-19) patients. Several studies have explored laboratory biomarkers used in the management and prognosis of COVID-19 patients during this pandemic; however, only a few focused on blood gas analysis. Determine the blood gas analysis pattern and its association with the outcome of severe COVID-19 patients treated in the Intensive Care Unit (ICU). This retrospective cohort study used secondary data from patients with severe COVI

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Shinohara, Michi M., and Andrei Shustov. "How I treat primary cutaneous CD30+ lymphoproliferative disorders." Blood 134, no. 6 (2019): 515–24. http://dx.doi.org/10.1182/blood.2019000785.

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Abstract The primary cutaneous CD30+ lymphoproliferative disorders are a family of extranodal lymphoid neoplasms that arise from mature postthymic T cells and localize to the skin. Current classification systems recognize lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma, and borderline cases. In the majority of patients, the prognosis of primary cutaneous CD30+ lymphoproliferative disorders is excellent; however, relapses are common, and complete cures are rare. Skin-directed and systemic therapies are used as monotherapy or in combination to achieve the best dise

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Wirgenes, Katrine Verena, Martin Tesli, Elin Inderhaug, et al. "ANK3 gene expression in bipolar disorder and schizophrenia." British Journal of Psychiatry 205, no. 3 (2014): 244–45. http://dx.doi.org/10.1192/bjp.bp.114.145433.

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SummaryANK3 gene variants have consistently been associated with bipolar spectrum disorder and schizophrenia spectrum disorder. However, the relevance of its encoded protein, ankyrin-3, in these disorders remains elusive. Here, we show that ANK3 gene expression in blood is significantly increased in bipolar disorder and schizophrenia compared with healthy controls. Additionally, we identified potential cis-acting expression quantitative trait loci located close to the transcription start site of one of the isoforms of the gene. These findings suggest that ANK3 mRNA is an interesting marker for

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Sathi, Bindu Kanathezhath, Latha B. Rao, Terea Giannetta, et al. "Prevalence of Rare Bleeding Disorders in the Central California Cohort: A Retrospective Single Institution Analysis." Blood 142, Supplement 1 (2023): 5488. http://dx.doi.org/10.1182/blood-2023-190315.

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Abstract Rare bleeding disorders (RBD) constitute 3- 5% of all inherited clotting factor deficiencies and include inherited deficiencies of fibrinogen (FI), factors II, V, VII, X, XI and XIII, and combined factor V and VIII, and affect both sexes in an autosomal recessive manner. Rare platelet disorders can also present with bleeding diathesis which are recessively inherited. Significant clinical heterogeneity is present in these disorders with varying bleeding symptomatology causing diagnostic and therapeutic challenges. The objective of this study was to analyze the prevalence, characteristi

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Kirk, Kaylyn, Katharine Hooper, Ritika Vankina, and Swarup Kumar. "A Retrospective Review Assessing the Development of Myelodysplastic Syndromes in Patients with Plasma Cell Dyscrasias." Blood 142, Supplement 1 (2023): 6499. http://dx.doi.org/10.1182/blood-2023-189099.

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Introduction Myelodysplastic syndrome (MDS) are hematopoietic disorders defined by dysplasia of the myeloid lineage accompanied by persistent cytopenias, and recurrent cytogenetic abnormalities (MDS). Whilst therapy related myeloid disorders in patients with Multiple Myeloma have been well described, there is lack of information regarding co-occurrence of these disease states in early plasma cell disorders as well as multiple myeloma at diagnosis which may also then allude to whether there is a founder effect to the clones. Recent advances in commercial sequencing assays of genomic data have a

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Munir, Iqra, and Sidra Raza. "A Review on Red Blood Disorder: Thalassemia." JOURNAL OF MICROBIOLOGY AND MOLECULAR GENETICS 2, no. 2 (2021): 1–8. http://dx.doi.org/10.52700/jmmg.v2i2.29.

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Thalassemia is classified as major (homozygous), minor (heterozygous) or intermedia (compound heterozygous). It’s diagnosed is based on hematological findings whereas molecular genetic analysis has also been gradually developed. Due to untreatable nature of thalassemia, it is important to adopt preventive measures. In this regard, the community awareness, carrier testing and genetic counselling are important milestones. Region-wise division of thalassemia mutations is diverse in distinct provinces. HBB: c.92+5G > C represents raised incidence in Balochistan and Sindh. HBB: c.27_28insG is mo

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Morinobu, Shigeru, Katsuo Sagawa, Shinobu Kawakatsu, Shiro Totsuka, and Akio Komatani. "Regional Cerebral Blood Flow in Affective Disorder." Psychiatry and Clinical Neurosciences 46, no. 2 (1992): 570. http://dx.doi.org/10.1111/j.1440-1819.1992.tb00944.x.

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45

Nelson, Kathleen. "Rare blood disorder links kinases and cancer." Lancet Oncology 4, no. 5 (2003): 264. http://dx.doi.org/10.1016/s1470-2045(03)01064-7.

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46

Bolwig, T. G. "Regional cerebral blood flow in affective disorder." Acta Psychiatrica Scandinavica 87, S371 (1993): 48–53. http://dx.doi.org/10.1111/j.1600-0447.1993.tb05374.x.

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47

Aschenbrenner, Diane S. "New Drug Treats Rare Blood Clotting Disorder." AJN, American Journal of Nursing 119, no. 6 (2019): 24. http://dx.doi.org/10.1097/01.naj.0000559801.16738.00.

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48

Sancar, Feyza. "New Treatment for Rare Blood Clotting Disorder." JAMA 321, no. 11 (2019): 1042. http://dx.doi.org/10.1001/jama.2019.1826.

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49

Boxer, Michael, and Alex E. Denes. "Combined Myeloid and Lymphoid Malignancies in 13 Elderly Patients." Blood 142, Supplement 1 (2023): 6417. http://dx.doi.org/10.1182/blood-2023-174786.

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Abstract (sommario):

Disclosures Myeloid malignancies such as myelodysplasia (MDS) often evolve from age related clonal hematopoiesis (CH) with progression of variant allele frequencies. The Philadelphia negative myeloproliferative neoplasms (MPN) polythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF) are associated with mutations in JAK2, CALR, or MPL. Multiple myeloma (MM) and monoclonal gammopathies (MGUS) are felt to be age related, and the malignant cell is of lymphoid origin. Burkitt's Lymphoma is associated with EBV exposure and dysregulation of c-myc. However the etiology of most lymp

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50

Gowda, Sunil N., Sumit Chandak, Vishal Sawant, and Amit Kulkarni. "Comparison of neurocognitive deficit among euthymic bipolar I disorder patients, their first-degree relatives and healthy controls." International Journal of Advances in Medicine 4, no. 3 (2017): 656. http://dx.doi.org/10.18203/2349-3933.ijam20171513.

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Background: Bipolar patients often suffer from debilitating cognitive impairment in different stages of the disease (manic, depressive or euthymic states). We assessed and compared the frequency of neurocognitive deficit among individual with bipolar I disorder but currently in euthymic state, their first-degree blood relatives and healthy controls. In addition, we also probed further into the type of neurocognitive deficit that can be seen among them and observed the influence of sociodemographic characteristics with the occurrence of neurocognitive deficit in individual with bipolar I disord

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