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Letteratura scientifica selezionata sul tema "Breast cancer south africa"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 11 febbraio 2022

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Articoli di riviste sul tema "Breast cancer south africa"

1

Trupe, Lydia A., Anne Rositch, Lindsay Dickerson, Su Lucas e Susan C. Harvey. "Knowledge and Attitudes About Breast Cancer in Limpopo, South Africa". Journal of Global Oncology 3, n. 5 (ottobre 2017): 509–14. http://dx.doi.org/10.1200/jgo.2016.008102.

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Purpose Breast cancer survival is unacceptably low in many low-resource settings, including rural South Africa, where access to screening and treatment services is limited. To describe the context for implementing an early detection program, we assessed knowledge and attitudes toward breast cancer risk, early detection, and treatment. Methods We conducted a cross-sectional survey among 243 women presenting to Hlokomela Clinic in Hoedspruit, South Africa, during April and May 2016. We used quantitative and qualitative analyses to determine levels of knowledge of risk factors, symptoms, and treatment of breast cancer, as well as experience with and attitudes toward detection and treatment methods. Results Thirty-one percent of women correctly identified at least six of 12 risk factors for breast cancer, and 53.1% identified breast lumps as an important symptom. Although > 97% of women stated that self–breast examination and early detection were highly important and that they would seek care for changes in their breasts, only 33.3% of women reported performing self–breast examination, and only 24.3% reported receiving a clinical breast examination. Age and education were not associated with knowledge, and level of knowledge did not predict care-seeking behaviors or attitudes. Conclusion Although women demonstrated moderate levels of knowledge of breast cancer symptoms and risk factors and the importance of early detection, few women reported seeking services. These data demonstrate sufficient levels of knowledge and positive attitudes toward care seeking and suggest both a need and readiness for increased access to cost-effective services to facilitate early diagnosis and improved outcomes.
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Lambert, Madeleine, Emily Mendenhall, Andrew Wooyoung Kim, Herbert Cubasch, Maureen Joffe e Shane A. Norris. "Health system experiences of breast cancer survivors in urban South Africa". Women's Health 16 (gennaio 2020): 174550652094941. http://dx.doi.org/10.1177/1745506520949419.

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Background: Breast cancer is the most common cancer globally and among South African women. Women from socioeconomically disadvantaged South African communities more often present later and receive total mastectomy compared to those from more affluent communities who have more breast conserving surgery (which is less invasive but requires mandatory radiation treatment post-operatively). Standard chemotherapy and total mastectomy treatments are known to cause traumatizing side effects and emotional suffering among South African women; moreover, many women face limited communication with physicians and psychological support. Objective: This article investigates the experiences of women seeking breast cancer treatment at the largest public hospital in South Africa. Methods We interviewed 50 Black women enrolled in the South African Breast Cancer Study to learn more about their health system experiences with detection, diagnosis, treatment, and follow-up care for breast cancer. Each interview was between 2–3 hours, addressing perceptions, experiences, and concerns associated with breast cancer and comorbidities such as HIV and hypertension. Results: We found most women feared diagnosis, in part, because of the experience of chemotherapy and physical mutilation related to mastectomy. The importance of social support from family, religion, and clinical staff was fundamental for women coping with their condition and adhering to treatment and medication. Conclusions: These findings exemplify how interventions might promote early detection of breast cancer and better adherence to treatment. Addressing community perceptions of breast cancer, patient needs and desires for treatment, structural barriers to intensive therapies, and the burden of invasive treatments are imperative next steps for delivering better breast cancer care in Soweto and other resource-constrained settings.
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Prodehl, Leanne, e Carol Benn. "Triple negative breast cancer in a South African urban breast care centre." Journal of Clinical Oncology 35, n. 15_suppl (20 maggio 2017): e13067-e13067. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e13067.

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e13067 Background: Triple negative breast cancer (TNBC) is associated with advanced stage at presentation, aggressive tumour biology and poor outcomes. There is no published data for South Africa. Methods: A retrospective file review of TNBC cases at the Milpark Breast Care Unit in Johannesburg, South Africa, data were collected on presentation, treatment and outcomes. A prospective file review and telephonic interview were done for further follow up. Results: There were 196 patients with TNBC identified out of 1407 patients (13.9%), 135 patients were analysed. Stage at presentation was IIa and IIb in approximately half (46.7%) of the patients and IIIa, IIIb and IV in a third (31.8%). Patients presented with large tumours -71.8% were T2 to T4; and lymph node positive disease (55.6%). The majority of patients had high-grade, poorly differentiated tumours. The challenges when treating TNBC were reflected in the use of multimodality therapy; 92.2% of patients had chemotherapy, as neoadjuvant (59.3%), adjuvant or both. There were 93 (68.9%) patients treated with adjuvant radiation therapy. If neoadjuvant chemotherapy was given 91.2% had a response. Recurrences occurred in 33 patients, with a 5-year disease free survival of 72.5%, and preponderance to visceral metastases (45.2%). Recurrences occurred early, the median was 23.1 months and all had occurred within eight years. Younger patients (HR 1.58), tumour size and lymph node positivity (HR 4.42) were associated with increased risk of recurrence, but only lymph node positivity was significant (HR 4.42). Complete pathological response to neoadjuvant chemotherapy was associated with fewer recurrences if no tumour was found in either the breast or the lymph nodes (HR 0.33). The 5-year overall survival was 76.4%. There was no significant difference in survival for age, node status, nuclear grade, or complete pathological response, only tumour size at presentation was significantly associated. Conclusions: The prevalence of triple negative breast cancer in a South African breast care unit was similar to some European studies but less than studies in West and East Africa. Patients presented at an advanced stage and had poorer outcomes than luminal breast cancers.
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Kiyange, F., V. Walusansa, G. Mandosela, H. Nzereka Kambale, E. Luyirika e J. Orem. "The Role of South-to-South Partnerships in Developing Cancer Services in Africa". Journal of Global Oncology 4, Supplement 2 (1 ottobre 2018): 163s. http://dx.doi.org/10.1200/jgo.18.21200.

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Background and context: Despite being a growing public health concern in Africa, access to effective cancer treatment and pain relief is still limited in sub-Saharan Africa. The African Palliative Care Association (APCA) in collaboration with the American Cancer Society and the Ministry of Health of Swaziland have successfully implemented a South-to-South partnership which has facilitated the development and operation of a cancer unit in Mbabane National Hospital. Although the cancer burden continues to rise in Africa, many countries do not have established oncology services. They rely on cancer treatment, care and support through referral to neighboring countries or overseas, which is costly for governments and poses multiple challenges for patients and their families. Until recently, Swaziland has relied on cancer treatment and care in South Africa. This paper presents a model where the Uganda Cancer Institute (UCI) in Uganda has been facilitated to support the establishment of a cancer unit in Swaziland. Aim: The intervention aimed at providing technical assistance to the Ministry of Health of Swaziland to initiate and operate a cancer unit in Mbabane Government Hospital through a formal arrangement with the UCI. Strategy/Tactics: The planning and execution of activities was done by a tripartite of APCA, Uganda Cancer Institute a government entity and the Swazi Ministry of Health. Program/Policy process: Over a period of one year (Decemeber 2016 to December 2017) APCA, through a grant from the ACS formerly engaged the UCI to support the initiation and operation of a cancer unit in Swaziland. This was through expert exchange visits through which on-job training and mentorship was provided to a team of staff at Mbabane Government Hospital, with coordination by the Swaziland Ministry of Health. Experiential visits to Uganda were also organized for the lead pharmacist in Swaziland and a doctor to enable them set up and run a cancer unit in their country. The exchange visits provided a forum for both observation and application of knowledge and skills. Outcomes: A cancer unit was successfully established at Mbabane Government Hospital in Swaziland, which now provides services for patients, with breast cancer and expanding to include other cancers. The Swaziland Ministry of Health has been key to the success of this development and continues to identify human, financial and other resources to sustain the cancer unit. To date 69 patients have successfully undergone chemotherapy: 43 breast cancer, 22 Kaposi sarcoma, 2 colorectal cancer, 1 bladder cancer, 1 multiple myeloma. 21 health care workers were trained on cancer management; 9 doctors, 7 nurses and 5 pharmacists. What was learned: There are many opportunities for South-to-South partnership to support the establishment or improvement of cancer care. This model implemented in Swaziland can be replicated in other African countries. Documenting the model for replication in other countries is recommended.
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Jacobs, Inarie, Christine Taljaard-Krugell, Cristian Ricci, Hester Vorster, Sabina Rinaldi, Herbert Cubasch, Ria Laubscher et al. "Dietary intake and breast cancer risk in black South African women: the South African Breast Cancer study". British Journal of Nutrition 121, n. 5 (1 febbraio 2019): 591–600. http://dx.doi.org/10.1017/s0007114518003744.

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AbstractIncidence rates of breast cancer (BC) are increasing in South Africa. The aim of this study was to investigate the association between dietary intake and BC risk in black South African women. The study population included 396 BC cases and 396 population-based controls matched on age and residence, participating in the South African Breast Cancer study. Diet was assessed using a validated quantified FFQ from which twelve energy-adjusted food groups were formed and analysed. OR were estimated using conditional logistic regressions, adjusted for confounding factors, comparing highestv.lowest median intake. Fresh fruit consumption showed an inverse association with BC risk (OR=0·3, 95 % CI 0·12, 0·80) in premenopausal women, whilst red and organ meat consumption showed an overall inverse association with BC risk (OR=0·6, 95 % CI 0·49, 0·94 and OR=0·6, 95 % CI 0·47, 0·91). Savoury food consumption (sauces, soups and snacks) were positively associated with BC risk in postmenopausal women (OR=2·1, 95 % CI 1·15, 4·07). Oestrogen receptor-positive stratification showed an inverse association with BC risk and consumption of nuts and seeds (OR=0·2, 95 % CI 0·58, 0·86). Based on these results, it is recommended that black South African women follow a diet with more fruit and vegetables together with a decreased consumption of less energy-dense, micronutrient-poor foods such as savoury foods. More research is necessary to investigate the association between BC risk and red and organ meat consumption. Affordable and practical methods regarding these recommendations should be implemented within health intervention strategies.
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Bosire, Edna N., Emily Mendenhall e Lesley Jo Weaver. "Comorbid Suffering: Breast Cancer Survivors in South Africa". Qualitative Health Research 30, n. 6 (24 marzo 2020): 917–26. http://dx.doi.org/10.1177/1049732320911365.

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Cycles of chronic illness are unpredictable, especially when multiple conditions are involved, and that instability can transform “normal” everyday life for individuals and their families. This article employs a theory of “comorbid suffering” to interpret how multiple concurrent diagnoses produce webs of remarkable suffering. We collected 50 life stories from breast cancer survivors enrolled in the South Africa Breast Cancer Study. We present three women’s narratives who grapple with comorbid suffering and illness-related work, which arise interpersonally when comorbid illnesses affects social interactions. We found that women strive to create a balance between living with comorbid suffering and continuously performing routine activities amid treatment. Discrimination and isolation were underpinned by women’s fear of being rejected by their families or how their illnesses created social distance between family members and the wider community. This study therefore illustrates how comorbid suffering requires intensive family commitments amid and beyond illness.
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Moodley, Shun Devan, Alicia McMaster e Rashem Mothilal. "Taxpas: Epidemiological and Survival Data in Breast Cancer Patients Treated with a Docetaxel-Based Chemotherapy Regimen in South Africa". Journal of Cancer Research 2013 (11 dicembre 2013): 1–5. http://dx.doi.org/10.1155/2013/308236.

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Breast cancer is the leading cancer among South African women. There is limited South African epidemiological data on triple-negative breast cancer (TNBC). Taxpas was a nonrandomized observational survey conducted in multiple centres in South Africa from April 2004 to December 2010. 1632 female patients diagnosed with breast cancer, with a median age of 51 years, were enrolled in the survey. Patients were treated on a docetaxel-based chemotherapy regimen. The objective of the study was to assess epidemiological data and survival data. The incidence of TNBC was 14%. The one-year survival rate for the total cohort was 84%. The one-year survival rate for patients with early stage and metastatic breast cancer was recorded as 94% and 65%, respectively. Patients with TNBC stage III (all ages) and stage IV (≤50 years) had statistically significant worse 1-year survival rate compared to N-TNBC patients of the same age and stages. Conclusion. The incidence of TNBC in South Africa which is 14% is comparable to global incidence. The 1-year survival data for certain subgroups supports the literature saying that TNBC carries a worse prognosis compared to N-TNBC. Women ≤50 years diagnosed with late stage TNBC carried the worst prognosis in this survey.
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Saberian, Mehran, Kamran Mehrabani e Hadi Raeisi Shahraki. "Clustering time trends of breast cancer incidence in Africa: a 27-year longitudinal study in 53 countries". African Health Sciences 21, n. 1 (16 aprile 2021): 47–53. http://dx.doi.org/10.4314/ahs.v21i1.8.

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Background: Breast cancer is the most common, frequently diagnosed cancer with the highest incidence among female worldwide. Although the incidence is decreasing in developed countries, it is on increase in most of the African countries. Objective: This study aimed to identify different time trends of breast cancer incidence among African countries using latent mixture approach. Methods: The information includes newly diagnosed breast cancer patients per 100,000 women for 53 African countries in a period of 1990-2016. Latent mixture modeling was performed in Mplus 7.4 software. Results: The overall trend of breast cancer in Africa was increasing. Latent mixture model with 5 clusters was estimated as the best using fit indices and linear growth trajectories were specified for each cluster. Nigeria was the only country which belongs to a cluster with negative slope indicating a slow decrease in the breast cancer incidence; also, Seychelles was the only country that showed a sharp increase over time. 31 countries belonged to a cluster with a slope of 0.08, indicating that the incidence of breast cancer is almost constant over time. Cluster 3 including Algeria, Angola, Botswana, Central African Republic, Cote d’lvoire, Equatorial Guinea, Lesotho, Libya, Namibia, Somalia, Sudan, Swaziland, Uganda and Zimbabwe and cluster 2 including Gabon, Mauritius, Morocco, South Africa, Tunisia and Congo showed a slow and moderate increase in the incidence of breast cancer, respectively. Conclusion: Providing health education programs is essential in African countries with rising trend of breast cancer during the last decades. Keywords: Africa; breast cancer; incidence; latent mixture model; trend.
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Cubasch, Herbert, Paul Ruff, Maureen Joffe, Shane Norris, Tobias Chirwa, Sarah Nietz, Vinay Sharma et al. "South African Breast Cancer and HIV Outcomes Study: Methods and Baseline Assessment". Journal of Global Oncology 3, n. 2 (aprile 2017): 114–24. http://dx.doi.org/10.1200/jgo.2015.002675.

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Purpose In low- and middle-income, HIV-endemic regions of sub-Saharan Africa, morbidity and mortality from the common epithelial cancers of the developed world are rising. Even among HIV-infected individuals, access to antiretroviral therapy has enhanced life expectancy, shifting the distribution of cancer diagnoses toward non–AIDS-defining malignancies, including breast cancer. Building on our prior research, we recently initiated the South African Breast Cancer and HIV Outcomes study. Methods We will recruit a cohort of 3,000 women newly diagnosed with breast cancer at hospitals in high (average, 20%) HIV prevalence areas, in Johannesburg, Durban, Pietermaritzburg, and Empangeni. At baseline, we will collect information on demographic, behavioral, clinical, and other factors related to access to health care. Every 3 months in year 1 and every 6 months thereafter, we will collect interview and chart data on treatment, symptoms, cancer progression, comorbidities, and other factors. We will compare survival rates of HIV-infected and uninfected women with newly diagnosed breast cancer and their likelihood of receiving suboptimal anticancer therapy. We will identify determinants of suboptimal therapy and context-specific modifiable factors that future interventions can target to improve outcomes. We will explore molecular mechanisms underlying potentially aggressive breast cancer in both HIV-infected and uninfected patients, as well as the roles of pathogens, states of immune activation, and inflammation in disease progression. Conclusion Our goals are to contribute to development of evidence-based guidelines for the management of breast cancer in HIV-positive women and to improve outcomes for all patients with breast cancer in resource-constrained settings.
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Odedina, Folakemi T., Delva Shamley, Ifeoma Okoye, Adaora Ezeani, Ntokozo Ndlovu, Yvonne Dei-Adomakoh, Kimberly Meza, Ruth Agaba, Parisa Fathi e Nissa Askins. "Landscape of Oncology Clinical Trials in Africa". JCO Global Oncology, n. 6 (settembre 2020): 932–41. http://dx.doi.org/10.1200/jgo.19.00189.

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PURPOSE The burden of cancer in Africa is of significant concern for several reasons, including that incidence of cancer in Africa continues to rise while Africa is also dealing with communicable diseases. To combat cancer in Africa, oncology clinical trials are needed to develop innovative interventions for cancer prevention, screening, diagnosis, treatment, and survivorship. Unfortunately, there is a paucity of clinical trials in Africa and it is difficult for African clinicians to get information on open oncology clinical trials and impossible for African patients with cancer to access this information. The primary objective of this study was to identify open oncology clinical trials in Africa. METHODS This project was part of a large-scale study to develop an African Virtual Platform for Oncology Clinical Trials Registry. The study was a quantitative, web-based, retrospective review of clinical trials registries. RESULTS A total of 109 open oncology clinical trials were identified. Most of the trials were in Egypt, South Africa, Algeria, and Kenya. The top cancer types for oncology clinical trials in Africa were breast, cervical, and lung cancers. The top sponsor of oncology clinical trials in Africa was academic institutions, especially institutions in the United States. CONCLUSION The paucity of clinical trials in Africa will continue to magnify the global disparities of cancer in the African population. Clinical trials are needed to ensure therapeutic interventions are safe and effective in the African population. In the era of personalized and precision health, it no longer suffices to assume that drugs developed in North America, Europe, or Asia will be effective in the African population.
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Più fonti

Tesi sul tema "Breast cancer south africa"

1

Agenbag, Gloudi. "Molecular genetic analysis of familial breast cancer in South Africa". Thesis, Link to the online version, 2005. http://hdl.handle.net/10019/953.

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Kramer, Nicole. "Prevalence of shoulder morbidity after treatment for breast cancer in South Africa". Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/27973.

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Introduction: Breast cancer is the most frequently diagnosed cancer and leading cause of cancer death among women and represents a considerable public health burden in South Africa and other low-middle income countries. Breast cancer management comprises single or combination treatment including surgery, radiotherapy and chemotherapy. Short and long-term complications of these treatments include shoulder morbidities such as pain, decreased range of motion, tightness, weakness, pain, numbness and lymphoedema, and may be present for up to 6 years post-surgery. An understanding of baseline demographic and clinical risk factors can guide rehabilitation and management strategies for high risk patients. Materials and Methods: This study was a cross-sectional analysis of the prevalence of shoulder pain and dysfunction in women attending their post-treatment annual follow up visit for unilateral breast carcinoma. The aim of this study was to quantify the burden of shoulder pain and disability in a tertiary academic hospital in Cape Town, South Africa, and identify potential risk factors for the development of shoulder morbidity. The primary objective of this study was to determine the prevalence of shoulder morbidity and the secondary objective was to evaluate associations between shoulder morbidity and risk factors such as treatment protocol or baseline demographics. Results: The majority of patients were of mixed ancestry, had their left side affected, received ALND and had undergone Modified Radical Mastectomy. The mean age was 60 years with a mean follow-up since surgery of 6 years. Three-quarters of patients reported a presence of pain or disability; 9% experienced severe pain and disability. Multivariable ordinal logistic regression analysis identified race, side, axillary surgery, chemotherapy and age as significant predictors of pain, and chemotherapy a significant predictor of disability. Discussion: The substantial burden of shoulder morbidity in this population represents a significant public health burden. The use of identified clinical and demographic characteristics may guide in the development of survivorship programmes incorporating surveillance and management of these high risk patients.
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Daries, Valdiela. "The profile of breast cancer among patients attending a Breast Clinic in Cape Town, South Africa". Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/6033.

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Includes abstract.
Includes bibliographical references.
Breast cancer is the leading cancer among women in South Africa (SA). Studies conducted in developing countries have shown that the majority of women present with advanced stage breast cancer at diagnosis. There is a gap in terms of recent data on the profile of breast cancer patients in SA. The purpose of the study was to obtain recent data with regards to the sociodemographic, clinical and risk factor profile of breast cancer in patients who presented at a Breast Clinic linked to a tertiary public hospital in the Western Cape in order to underpin the development of strategies for earlier detection and diagnosis of breast cancer. A cross-sectional descriptive medical record review was conducted. The studypopulation included all newly diagnosed patients with histological or cytological confirmedbreast cancer who presented at the Breast Clinic during the period 01 January 2009 to 31December 2010. All patients with a previous diagnosis of breast cancer were excluded. Data onthe socio-demographic, clinical and risk factor profile of breast cancer patients were collectedusing a standardised data capture sheet. Data was entered using Epidata version 3.1 and analysedusing Stata Statistical package version 12.After calculation of initial descriptive analysis for the whole sample, male subjects wereexcluded and further analysis was restricted to 585 female subjects. Stage at presentation wascategorised as “early stage” (stage 0, I, IIA, IIB) and “late stage” (stage IIIA, IIIB, IIIC, IV). Crude associations of potential predictors with stage at presentation were tested using Wilcoxon rank-sum tests for medians and Chi-square tests and Fischer Exact tests for proportions. Logistic regression was used to create a model with stage at presentation as dependent variable. Age and racial group were introduced in the model as possible confounders. Based on literature findings other variables present in the dataset were considered as potential predictors of stage at presentation (namely place of residence, employment status, medical aid status, family history of breast cancer, menopausal status, parity, having ever smoked or used alcohol, clinical signs of breast cancer as well as duration of symptoms) and introduced in the model if their bivariate association with the outcome (adjusted for age and race) was statistically significant. A significance level of p <; 0.15 was used. The only variable showing a significant association according to this criterion was the ordinal variable duration of symptoms. The final logistic regression model, therefore, included stage at presentation as the dependent variable and age, racial group and symptom duration as predictors.
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Scullard, Nicole. "Subjective lived experiences of women with early stage breast cancer in Cape Town". University of the Western Cape, 2015. http://hdl.handle.net/11394/5081.

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Magister Artium - MA
Breast cancer is a common cause of death among women worldwide. It has long been recognized as a major public health burden in high-income countries, however, the majority of cases are said to occur in low and middle-income countries, such as in South Africa. A breast cancer diagnosis and treatment heralds a series of frightening events and can be a traumatic experience. The manner in which women perceive and cope with their illness is predictive of emotional and physical health outcomes. It is thus imperative to explore the experiences of South African women, whose voices may have been silenced in the past. The purpose of my study was to explore the subjective lived experiences of women with early stage breast cancer undergoing treatment. The objectives of the study were to; explore the emotional experiences of women with early stage breast cancer undergoing treatment and secondly to explore how women perceive their bodies through their experience of early stage breast cancer while undergoing treatment. Phenomenology was used as the theoretical position conceptualising the study as well as the research design. This research study adopted a qualitative approach utilising in-depth face to face semi-structures interviews for collecting data. The participants were selected through purposive sampling and comprised six women aged between 30 and 40 who are undergoing treatment for early stage breast cancer. The data was analysed using interpretative phenomenological analysis. Emotions experienced were characterised by the shock of the diagnosis due to factors such as lack of family history and age. Participants reported positive changes and viewpoints which they gained through their breast cancer journey. Emotions were heightened during treatment due to the physical change experienced and the effects this had on family members and the general public. Furthermore, results indicated that participants, even though they discovered a new found love for life and for their wellbeing, neglected their emotional needs in order to protect family members. An additional reason for this neglect centered on the lack of understanding other individuals may have regarding the experiences of participants. Recommendations involves the encouragement of accessing counselling services and that interventions tailored to the needs of each patient especially according to age. All ethical considerations as stipulated by the University of the Western Cape were adhered to.
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Sunkara, Ranga Rao. "Comparative study of breast cancer in the United States, India, and South Africa: 1996- present". DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2001. http://digitalcommons.auctr.edu/dissertations/1693.

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This study identifies forces that prevent or contribute to women's participation in breast cancer screening and other breast cancer prevention activities. The study was based on the premise that women from the lower socioeconomic groups in India, South Africa, and the United States had a higher rate of breast cancer because they are diagnosed at the more advanced stages of the disease and do not engage in breast screening opportunities. Moreover, there is limited access to services and transportation, and there is little faith in the professional health care provider and the treatment received from the health care provider. Surveys and interviews were used to assess the women's level of involvement in breast cancer related prevention programs. Similar methods were used to assess the level of involvement by health care professionals in providing breast cancer prevention activities. The researcher found that the issues related to breast cancer are comparable in South Africa, India, and the United States. Further, it was found that, for the women in all three countries, there was a lack of access to health care; thus, women were not receiving the medical treatment they needed; the women were diagnosed at the more advanced stages of the disease; there was a lack of available transportation to the sites where they could participate in health prevention programs; there was a lack of information about breast cancer made available to women of color; and the level of participation in health care programs is related to the socioeconomic conditions and to the cultural aspects of some women's lives and the long waiting periods for medical services. The conclusion drawn from the findings suggests that a culture-sensitive model is needed for women of color, and health care professionals need to be more sensitive to the needs of women regardless of socioeconomic level. The three countries should consider holding global workshops on breast cancer, and health clinics and other medical facilities should send reminder cards to female patients or have health care workers do home visits to remind patients of the need for mammogram.
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Ng'ang'a, Mukuhi. "Delay in provision of breast cancer care in patients seen at a district hospital diagnostic breast unit in South Africa". Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/28069.

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Background: There is evidence to show that delays in breast cancer management are detrimental to patient outcome. The aim of this study was to determine time trends and causes of delay in a newly established diagnostic breast clinic based at a district hospital in South Africa. Method: All patients who presented to Mitchells Plain District Hospital Breast Clinic from January to December 2015 and had a diagnosis of breast cancer were included in this study. The intervals between the time she first noted her symptoms to initial contact with a health professional and delivery of definitive therapy was documented. Patient delay referred to the interval from when the patient first noted her symptoms to her initial contact with a health care provider. Provider delay referred to the interval between the first hospital visit and onset of therapy. Result: A total of 33 patients were enrolled in this study. The median overall total delay (time lapse between the moment the patient first noticed her symptoms to time definitive anti-cancer treatment was started) was 157days, (range 29 to 839 days). Median patient delay (time lapse between the moment the patient first noticed her symptoms and the visit to a health professional) was 56 days, (range 7 to 730 days). Median overall provider delay (time lapse between the patients' first encounter with a clinician to time definitive anti-cancer treatment was started) was 84 days, (range 22 to 338 days). Median Referral delay was 11 days (range 4 to 39 days). Median Diagnostic delay was 15 days (range 9 to 135 days) and median treatment delay was 45 days (range 5 to 246 days). Conclusion: The median overall total delay for patients diagnosed with breast cancer at Mitchells Plain District Hospital does not compares well with institutions in developed nations but it is similar to studies done in developing nations. The largest contributor to this delay was patient delay. The main contributors to provider delay was related to diagnosis (almost exclusively related to tissue diagnosis) and treatment (mainly patients who received surgery as their first definitive therapy).
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Kamanga, Thembekile Nokukhanya. "A microsociological analysis of social support to women diagnosed with early stage breast cancer". Thesis, University of the Western Cape, 2016. http://hdl.handle.net/11394/5536.

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Magister Artium - MA
This study explored the social support provided by family of women diagnosed with early stage breast cancer. The aim was to present an account of social support that is solicited by and given to women diagnosed with early stage breast cancer. There is a dearth amount of literature on support from families of women with breast cancer in South Africa. Thus, this study can potentially contribute to filling the gap of knowledge in this area in the country. Qualitative method was used and in-depth interviews were utilized to study the women's experience of family social support. The theoretical framework underpinning the study is the relational communicational perspective.
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Hassan, Mohammed Hashim Abdalraheem. "Characterization of ATP-binding cassette drug transporters and their role in breast cancer treatment using in silico approach". University of the Western Cape, 2019. http://hdl.handle.net/11394/7255.

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Abstract (sommario):
>Magister Scientiae - MSc
Breast cancer is the most common cancer in women worldwide, and is the second most common cancer in the world, responsible for more than 500 000 deaths annually. Estimates are that 1 in 8 women will develop breast cancer in their lifetime. In South Africa, breast cancer in women affects about 16.6 % of the population and could see a 78 % increase in cases by 2030. Comprehensive therapy on breast cancer including surgical operation, chemotherapy, radiotherapy, endocrinotherapy, etc. could help, but still has serious side effects. The Chemotherapy resistance against anticancer drugs is an emerging concern. Biomarkers have been identified as a viable option for early detection and progression of disease. Examples of biological indicators for disease could be the ATP-binding cassette (ABC) drug transporters that utilizes the energy derived from ATP hydrolysis to efflux many chemically diverse compounds across the plasma membrane, thereby playing a critical and important physiological role in protecting cells from xenobiotics. These transporters are also implicated in the development of multidrug resistance (MDR) in cancer cells that have been treated with chemotherapeutics. High expression of these membrane proteins as a family of ABC drug transporters are one of the main reasons for drug resistance by increasing the efflux rate of the anti-cancer drug from cancer cells. ABC drug transporters are considered to be one of the largest protein families in living organisms. There are 48 genes in the human genome that encode ABC transporters, which are divided into seven subfamilies (ABCA-ABCG). Studies revealed that ABC transporter genes has been shown to be associated with tumour development, progression and response to therapy, suggesting their possible use as diagnostic, prognostic and predictive biomarkers. The aim of this study was to investigate and identify novel ABC transporter genes that could be implicated in breast cancer and MDR and potentially would be a therapeutic target for successful chemotherapy treatment and disease progression and survival in breast cancer patients. An in silico approach was used to identify 10 ABC transporter genes (ABCB2, ABCB9, ABCB10, ABCC1, ABCC4, ABCC5, ABCC10, ABCC11, ABCC12, ABCD1) implicated in breast cancer by conferring drug resistance through over-expression in cancer cells. The in silico study investigated the tissue expression specificity, protein interaction/s, pathways, and comparative toxicogenomics of the identified ABC transporter genes using several computational software such as Tissue-specific Gene Expression and Regulation (TiGER), the Human Protein Atlas (HPA), Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), and The Comparative Toxicogenomics Database (CTD). The 48 ABC transporter genes were shortlisted through very selective criteria that narrowed the genes down to 10. Differential expression analysis of the genes using TiGER and HPA compared expression in normal versus cancerous tissue of the candidate genes. The result showed that ABCC11 was preferentially expressed in breast tissue with an enrichment value higher than 10.0. The results also showed ABCC10 overexpressed in breast cancer tissue, making these two genes top candidates for further analysis. Result from STRING database showed a strong functional interaction network between the prioritized genes through protein homology, co-expression and text mining as evidence for the observed interactions. Furthermore, the prioritized list of genes was submitted to the CTD for intersectional analysis to obtain the toxicity relationship between the genes and the Tamoxifen as the first line chemotherapeutic treatment for breast cancer. Venn diagrams obtained from CTD showed intersectional relation between ABCB2, ABCC1, ABCC4, ABCC11, and ABCD1 genes and Tamoxifen. Furthermore, an in silico validation of the prognostic/predictive values of the 10 prioritized genes (list 2) was carried out using an online biomarker validation tool and database for cancer gene expression data using survival analysis (SurvExpress) and gene expression based survival analysis web application for multiple cancer (PROGGENE). Results obtained from the PROGGENE survival and predictive analysis showed good prognostic values for the genes ABCB2, ABCC1, ABCC4, ABCC10 and ABCC12 with their significance measured by the probability value (Pv) (0.053, 0.001118, 0.01286, 0.00604, 0.00157 respectively). From this study ABCC1, ABCC4, ABCC5, ABCC10, and ABCC11 genes could serve as putative therapeutic target biomarkers for breast cancer treatment following further in depth analysis. However, the variance in the effectiveness of individual genes suggests that the set of genes would perform better than individual gene in the management of breast cancer. The modulating roles of ABCC4, ABCC5 ABCC10, and ABCC11 in drug induced apoptosis, suggest they could probably play an important role in personalized medicine and could serve as biomarkers to monitor the prognosis and/or therapeutic outcome of chemotherapy drugs in breast cancer patients. The use of modern genomics, proteomics, bioinformatics, and systems biology approaches has resulted in a substantial increase in our ability to identify molecular mechanisms that are involved in MDR in cancer and to find drugs that may block or reverse the development of drug resistance. By using an in silico approach in this study, a list of five ABC transporter genes were identified, of which two (ABCC10 and ABCC11) could potentially serve as prognostic and predictive biomarkers for the management of breast cancer treatment.
2022-04-30
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Winchester, Carolyn Margaret. "Anti-p53 and c-erbB2 as prognostic markers in South African breast cancer patients". Thesis, Cape Technikon, 2000. http://hdl.handle.net/20.500.11838/1518.

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Abstract (sommario):
Thesis (DTech(Biomedical Technology))--Cape Technikon, Cape Town, 2000
The diagnosis of breast cancer is not possible using currently available serological detection of cancer markers as these lack adequate sensitivity or specificity. This study investigates the prevalence and significance of anti-p53 antibody and c-erbB-2 protein in the post-surgical sera of South African breast cancer patients and correlates these features with the clinicopathological characteristics of breast cancer. Further, this study investigates the possibilityofimproving prognostic sensitivityby combining the two subject markers to monitor each patient. Further, this study will provide the opportunity to investigate lNhether only certain types of breast cancer can elicit an immunological response and at what stage and grade of tumour antibodies are present in the postoperative serum. The study also establishes a foundation for determining in South Africa lNhether there is a genetic influence in the response to p53 mutation and INhther this response is higher in the indigenous African women compared to other South African women. The purpose of the study is to determine if the resulting findings can be used to enhance our ability to diagnose breast cancer and to identify node-negative breast cancer patients at high risk for early disease recurrence and or death, for 1Nh0m adjuvant therapy is unequivocally justified. The study accrued 92 South African breast cancer patients who were essentially women of colour 62 [67%] indigenous African women and 20 [22%] Caucasian of Indian descent, 6 [6%J of mixed [ColouredJ background and only 4 [4%J Caucasian of White descent. A predominantly indigenous African populationwas chosen becausethey are the group most likely to benefitfrom an easily repeatable, affordable serological cancer marker.
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Mentoor, J. L. D. (Juliet Lewie Dionee). "Identification of rare gene variants in South African breast cancer families through next generation sequencing". Thesis, University of Pretoria, 2017. http://hdl.handle.net/2263/63043.

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Abstract (sommario):
Breast cancer (BC) has become the leading cancer amongst women in South Africa. The overall life time risk for developing this disease is one in 12 (National Cancer registry, 2000- 2011). A strong family history (≥3 affected) is an important factor for inherited predisposition to BC that accounts for approximately 10% of cases worldwide. Mutations in several high- and moderate risk breast cancer genes have been associated with familial BC and includes BRCA1, BRCA2, TP53, PALB2, and CHEK2. Individuals that carry germline mutations in BRCA1 and BRCA2 possess an 80% lifetime risk for BC. Mutations in BRCA1 and BRCA2 are responsible for 29% and 25% of familial BC worldwide. In South Africa BRCA1 mutations account for 19% and BRCA2 for 47% of familial breast cancer. Mutations associated with a moderate risk for BC account for ~1% of cases. This data suggests that ~30% of South African BC families are not characterised by pathogenic mutations in known breast/ovarian (BC/OVC) genes. The purpose of the present study was to identify gene variants that may predispose to breast cancer. Next generation sequencing was performed to investigate the germline DNA of highrisk BC/OVC families that have previously tested negative for premature truncating mutations in BRCA1/2, PALB2 and RAD51C. Paired-end whole exome sequencing was performed with nine index cases, selected from six families with a strong background for BC/OVC. This resulted in the discovery of an average of 26 000 coding variants in index cases. Gene prioritisation strategies were incorporated to filter all exome variants and identify high-priority genes for further analysis. After sequence verification, three high-priority genes were selected for further analysis. The three genes coded for; a novel putative tumour suppressor (TCHP) that is pro-apoptotic; the XPF-endonuclease homolog, EME2; and a POLQ like helicase enzyme (HELQ). Prioritised genes were screened in a total of 61 high-risk families and cohorts of patients with BC or OVC without a family history for their disease. Two potentially damaging variants (stop-gain & inframe amino acid deletion) were identified in TCHP, four (frameshift, nonsense & two in-frame deletions) in EME2 and one frameshift mutation in HELQ in high-risk families and cases that were without a family history for BC/OVC. The analyses performed in the last section of this project was aimed at identifying other potential genes of interest by making use of a list of 516 well recognised and putative DNA repair genes. Through this approach, one additional truncating mutation in POLN (p.Q837SfsX7) was highlighted as a potential gene of interest for future investigation. Despite the key roles that the high-priority genes play in their respective processes, the present study could not verify that the potential loss of function variants discovered make an appreciable contribution towards BC/OVC susceptibility in our setting. Further investigation is necessary to validate their involvement in breast/ovarian cancer predisposition.
Thesis (PhD)--University of Pretoria, 2017.
Genetics
PhD
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Libri sul tema "Breast cancer south africa"

1

Where the river ends. [London]: Ebury, 2008.

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Nielsen, Jerri. Ice bound: A doctor's incredible battle for survival at the South Pole. New York: Hyperion Books, 2001.

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Nielsen, Jerri. Ice bound: A doctor's incredible battle for survival at the South Pole. New York: Talk Miramax Books/Hyperion, 2001.

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Maryanne, Vollers, a cura di. Ice bound: One woman's incredible battle for survival at the South Pole. London: Ebury, 2001.

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Nielsen, Jerri. Ice bound: A doctor's incredible battle for survival at the South Pole. Thorndike, Me: Thorndike Press, 2001.

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Nielsen, Jerri. Ice bound: A doctor's incredible battle for survival at the South Pole. New York: Hyperion Books, 2001.

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7

Coetzee, J. M. Age of iron. New York: Vintage Books, 1992.

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Coetzee, J. M. Age of Iron. New York: Random House, 1990.

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Coetzee, J. M. Age of Iron. London: Secker & Warburg, 1990.

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Coetzee, J. M. Tie qi shi dai. Taibei shi: Tian xia yuan jian chu ban gu fen you xian gong si, 2001.

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Capitoli di libri sul tema "Breast cancer south africa"

1

Smit, Anri. "Exploring the Use of Body Mapping for Socially Inclusive Storytelling Among South African Women Living with Recurrent Breast Cancer". In Handbook of Social Inclusion, 1–20. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-48277-0_64-1.

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Davenport, T. R. H. "The Cancer of Apartheid". In South Africa, 518–57. London: Palgrave Macmillan UK, 1991. http://dx.doi.org/10.1007/978-1-349-21422-8_20.

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Evans, Matthew, e Abeer M. Shaaban. "Breast Cancer in Sub-Saharan Africa". In Cancer in Sub-Saharan Africa, 81–93. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52554-9_6.

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Khaled, Hussein M. "Breast Cancer at Diagnosis in Women of Africa and the Middle East". In Breast Cancer in Women of African Descent, 81–90. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/978-1-4020-3664-4_5.

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Walker, A. R. P., M. I. Odendaal e I. Segal. "Cancer Patterns in Different Ethnic Groups in South Africa". In Dietary Fiber, 515–21. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2111-8_38.

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Rapoport, B. L. "Screening and Early Detection of Breast Cancer in Women in Africa and the Middle East". In Breast Cancer in Women of African Descent, 71–80. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/978-1-4020-3664-4_4.

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Volkert, H., A. Schachter, U. Schenck, R. Schmauz, H. J. Soost, G. Wikely e R. Busch. "Evaluation of Cervical Smears in a Comparative Study Between Countries with Different Incidences of Cervical Cancer (Israel, Germany, South Africa)". In New Frontiers in Cytology, 404–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73596-7_63.

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Benn, Carol. "Perspective from South Africa and sub-Saharan Africa". In Breast cancer: Global quality care, a cura di Lieve Wierinck, Benjamin Baelus, Emilie Hoogland, Donata Lerda, Robert Mansel, Cary Kaufman e Luzia Travado, 377–85. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198839248.003.0036.

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Abstract: A continent-wide review of surgical management of breast care in Africa described a disproportionate number of black African patients presenting with locally advanced and metastatic disease (stage 3 or 4). Only 25% presented with early-stage disease (stage 1 or 2). Investment in breast cancer research and treatment in low- and middle-income countries (LMICs) should be a global health priority. In South Africa and other LMICs the first screening goal is to reduce late presentation and late-stage disease through community-based population-level screening combined with open access to health care services for any women with breast symptoms. The aim is to decrease current provider-dependent delays. Increased availability of multidisciplinary teams functioning in specialist centres should improve access and thus decrease the numbers of locally advanced breast cancers presenting, with a knockdown effect on decreasing low survival rates.
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Kimman, Merel, Sanne Peters, Stephen Jan, Nirmala Bhoo-Pathy, Cheng Har Yip, Manuela Joore e Mark Woodward. "The Economic Impact of Breast Cancer in the South-East Asian Region". In Breast cancer: Global quality care, a cura di Manuela Joore, Xavier Pouwels e Bram Ramaekers, 298–306. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198839248.003.0028.

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Abstract: In many parts of the world, are not only the economic consequences of breast cancer a burden to society, but also patients and their families directly endure financial hardship after a breast cancer diagnosis. This chapter examines the economic consequences of breast cancer for patients and families in a low- and middle income setting. Results of a study on financial catastrophe and mortality after breast cancer diagnosis, conducted in several countries in South-East Asia, are described.
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Fagan, Johannes J., Pankaj Chaturvedi e Luiz P. Kowalski. "Treatment Options for Hypopharyngeal Cancer in Developing Countries in Africa/South America/Asia". In Hypopharyngeal Cancer, 159–66. S. Karger AG, 2019. http://dx.doi.org/10.1159/000492360.

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Atti di convegni sul tema "Breast cancer south africa"

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Moodley, Jennifer. "Abstract IA33: Pathways to breast cancer care in South Africa". In Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-ia33.

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Lupicki, Kamil, Selene Elifio-Esposito, Aline S. Fonseca, Akanksha Mahajan, Silma R. Pereira, B. Langa, Dhirendra Govender et al. "Abstract A14: Copy number profiling in South African breast cancer patients". In Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-a14.

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"Design, Characterization and In-vitro Study of Folic Acid Conjugated-Chitosan Functionalized Gold Nanoparticles for Targeted Delivery of 5-Fluorouracil in Breast Cancer". In Nov. 19-20 2018 Cape Town (South Africa). Eminent Association of Pioneers, 2018. http://dx.doi.org/10.17758/eares4.eap1118223.

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Sultana, Rizwana, Amal Ch Kataki, Bibhuti Bhusan Barthakur e Sujoy Bose. "Abstract A09: Role of adipocytokines in obesity associated Triple Negative Breast Cancer". In Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-a09.

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Joveini, Zahra, Zhaleh Behrouzkia e Reza Zohdi Aghdam. "Abstract A07: Hyperthermia plus radiotherapy in triple-negative breast cancer; before or after?" In Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-a07.

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Adams-Campbell, Lucile L. "Abstract IA32: Metabolic syndrome and breast cancer risk among black women: An exercise intervention". In Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-ia32.

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Salako, Olufisayo O., Augustine T. Nkembo, Elizabeth Ntantie e Nazarius S. Lamango. "Abstract A03: Novel polyisoprenylated small molecules as potential new therapies for triple negative breast cancer". In Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-a03.

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Kensler, Kevin H., Elizabeth M. Poole, Laura C. Collins, Andrew H. Beck, Bernard A. Rosner, A. Heather Eliassen, Susan E. Hankinson, Myles Brown e Rulla M. Tamimi. "Abstract A05: Androgen receptor expression and breast cancer survival in the Nurses' Health Study cohorts". In Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-a05.

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Joveini, Zahra, Zhaleh Behrouzkia e Reza Zohdi Aghdam. "Abstract A08: Hyperthermia plus radiotherapy in Estrogen receptor positive (ER+) breast cancer; before or after?" In Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-a08.

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Zienolddiny, Shan. "Abstract A01: Mechanisms of breast cancer risk in shift workers: Epigenetic changes in the circadian pathway". In Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-a01.

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