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Articoli di riviste sul tema "Cancer cell microenvironment"

Autore: Grafiati

Pubblicato: 2 novembre 2024

Ultima modifica: 31 luglio 2025

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1

Campbell, Caroline J., and Brian W. Booth. "The Influence of the Normal Mammary Microenvironment on Breast Cancer Cells." Cancers 15, no. 3 (2023): 576. http://dx.doi.org/10.3390/cancers15030576.

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The tumor microenvironment is recognized as performing a critical role in tumor initiation, progression, and metastasis of many cancers, including breast cancer. The breast cancer microenvironment is a complex mixture of cells consisting of tumor cells, immune cells, fibroblasts, and vascular cells, as well as noncellular components, such as extracellular matrix and soluble products. The interactions between the tumor cells and the tumor microenvironment modulate tumor behavior and affect the responses of cancer patients to therapies. The interactions between tumor cells and the surrounding en

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Shive, Heather R., John S. House, Jordan L. Ferguson, Dereje D. Jima, Aubrie A. Selmek, and Dillon T. Lloyd. "Abstract PR011: Characterization of the precancerous and cancer microenvironment in a zebrafish sarcoma model." Clinical Cancer Research 28, no. 18_Supplement (2022): PR011. http://dx.doi.org/10.1158/1557-3265.sarcomas22-pr011.

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Abstract Contributions of the microenvironment to soft tissue sarcoma progression are relatively undefined, representing a major impediment to identifying essential regulatory networks in sarcomagenesis. Furthermore, genetic and molecular characteristics that distinguish precancerous versus cancerous microenvironments are not well known across human cancer types. While animal models have the potential to reveal these complex processes, significant impediments to such inquiries include (1) the difficulty in distinguishing microenvironmental cells from precancerous or cancer cells in tissue spec

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Gibson, Spencer, Tricia Choquette, Elizabeth S. Henson, Xioyan Yang, and James B. Johnston. "Abstract 2516: Analysis of CLL Celllular Environment and Response (ACCER) is a novel method to understand the microenvironment in CLL." Cancer Research 83, no. 7_Supplement (2023): 2516. http://dx.doi.org/10.1158/1538-7445.am2023-2516.

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Abstract Microenvironments such as lymph nodes and bone marrow allow chronic lymphocytic leukemia (CLL) cells to survive after drug treatments. There are limited methods to study the to study the contribution of the microenvironment. We have adapted a solid tumour microenvironment cell culture system that provides elements of the CLL microenvironment called Analysis of CLL Cellular Environment and Response (ACCER). We optimized the cell number for patient’s primary CLL cells and HS-5 human bone marrow stromal cell line that will give sufficient cell number and viability with the ACCER. We then

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Bischoff, Philip, Alexandra Trinks, Benedikt Obermayer, et al. "Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma." Oncogene 40, no. 50 (2021): 6748–58. http://dx.doi.org/10.1038/s41388-021-02054-3.

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AbstractRecent developments in immuno-oncology demonstrate that not only cancer cells, but also the tumor microenvironment can guide precision medicine. A comprehensive and in-depth characterization of the tumor microenvironment is challenging since its cell populations are diverse and can be important even if scarce. To identify clinically relevant microenvironmental and cancer features, we applied single-cell RNA sequencing to ten human lung adenocarcinomas and ten normal control tissues. Our analyses revealed heterogeneous carcinoma cell transcriptomes reflecting histological grade and onco

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Aber, Etan R., Cristina F. Contreras, Mohd Omar Sikder, et al. "Abstract LB308: Transcriptional profiling uncovers a unified program underlying the human metastatic and adjacent microenvironments." Cancer Research 84, no. 7_Supplement (2024): LB308. http://dx.doi.org/10.1158/1538-7445.am2024-lb308.

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Abstract Metastasis is the primary cause of death in patients with solid tumors, yet the treatment-refractory metastatic microenvironment is poorly characterized. To gain a comprehensive understanding of microenvironmental regulation of human metastasis, we performed single-cell RNA sequencing covering endothelial, stromal, myeloid, lymphoid, and malignant cells from 28 lung and liver samples of the metastatic microenvironment and metastasis-free adjacent microenvironment from patients with metastatic adrenocortical carcinoma compared to healthy donors for a total of 275,903 cells. We discover

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Feng, Yinghua, Xiuli Zhang, Guangpeng Wang, et al. "Comprehensive Integrated Analysis Reveals the Spatiotemporal Microevolution of Cancer Cells in Patients with Bone-Metastatic Prostate Cancer." Biomedicines 13, no. 4 (2025): 909. https://doi.org/10.3390/biomedicines13040909.

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Background/Objectives: Bone metastasis is a frequent and life-threatening event in advanced cancers, affecting up to 70–85% of prostate cancer patients. Understanding the cellular and molecular mechanisms underlying bone metastasis is essential for developing targeted therapies. This study aimed to systematically characterize the heterogeneity and microenvironmental adaptation of prostate cancer bone metastases using single-cell transcriptomics. Methods: We integrated the largest single-cell transcriptome dataset to date, encompassing 124 samples from primary prostate tumors, various bone meta

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AbdelFattah, HebatAllah Samy, Mayar Tarek Ibrahim, Mostafa Mahmoud Nasr, and Shaimaa Nasr Nasr Amin. "Cell Signaling in Cancer Microenvironment." International Journal of Advanced Biomedicine 2, no. 2 (2017): 47–51. http://dx.doi.org/10.18576/ab/020204.

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Loberg, Robert D., Christopher J. Logothetis, Evan T. Keller, and Kenneth J. Pienta. "Pathogenesis and Treatment of Prostate Cancer Bone Metastases: Targeting the Lethal Phenotype." Journal of Clinical Oncology 23, no. 32 (2005): 8232–41. http://dx.doi.org/10.1200/jco.2005.03.0841.

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Traditionally, prostate cancer treatment, as well as all cancer treatment, has been designed to target the tumor cell directly via various hormonal and chemotherapeutic agents. Recently, the realization that cancer cells exist in complex microenvironments that are essential for the tumorigenic and metastatic potential of the cancer cells is starting the redefine the paradigm for cancer therapy. The propensity of prostate cancer cells to metastasize to bone is leading to the design of novel therapies targeting both the cancer cell as well as the bone microenvironment. Tumor cells in the bone in

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Garre, Elena, Anna Gustafsson, Maria Carmen Leiva, et al. "Breast Cancer Patient-Derived Scaffolds Can Expose Unique Individual Cancer Progressing Properties of the Cancer Microenvironment Associated with Clinical Characteristics." Cancers 14, no. 9 (2022): 2172. http://dx.doi.org/10.3390/cancers14092172.

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Breast cancer is a heterogeneous disease in terms of cellular and structural composition, and besides acquired aggressive properties in the cancer cell population, the surrounding tumor microenvironment can affect disease progression and clinical behaviours. To specifically decode the clinical relevance of the cancer promoting effects of individual tumor microenvironments, we performed a comprehensive test of 110 breast cancer samples using a recently established in vivo-like 3D cell culture platform based on patient-derived scaffolds (PDSs). Cell-free PDSs were recellularized with three breas

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Kim, Jaehong. "Regulation of Immune Cell Functions by Metabolic Reprogramming." Journal of Immunology Research 2018 (2018): 1–12. http://dx.doi.org/10.1155/2018/8605471.

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Recent findings show that the metabolic status of immune cells can determine immune responses. Metabolic reprogramming between aerobic glycolysis and oxidative phosphorylation, previously speculated as exclusively observable in cancer cells, exists in various types of immune and stromal cells in many different pathological conditions other than cancer. The microenvironments of cancer, obese adipose, and wound-repairing tissues share common features of inflammatory reactions. In addition, the metabolic changes in macrophages and T cells are now regarded as crucial for the functional plasticity

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Leach, Damien, Alison Buxton, Gilberto Serrano de Almeida, Grant Buchanan, and Charlotte Lynne Bevan. "Androgen Activity in the Primary and Metastatic Prostate Cancer Microenvironments Influences Disease Progression and Patient Outcomes." Journal of the Endocrine Society 5, Supplement_1 (2021): A1011. http://dx.doi.org/10.1210/jendso/bvab048.2068.

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Abstract Background: Cancers do not exist in isolation, surrounding tumours are supportive cells, which create the microenvironment in which cancer cells reside. In the prostate cancer (PCa), androgen receptor (AR) signalling in the surrounding fibroblasts is strikingly distinct from that within PCa cells, and has specific functions to produce, maintain, and modulate the extracellular matrix (ECM) which surrounds and interacts with PCa cells. The supportive cells of metastatic sites differ from those in the primary site and produce different types of cellular microenvironments. Since the adven

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Deng, Shuzhi, Shimeng Wang, Xueke Shi, and Hongmei Zhou. "Microenvironment in Oral Potentially Malignant Disorders: Multi-Dimensional Characteristics and Mechanisms of Carcinogenesis." International Journal of Molecular Sciences 23, no. 16 (2022): 8940. http://dx.doi.org/10.3390/ijms23168940.

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Oral potentially malignant disorders (OPMDs) are a group of diseases involving the oral mucosa and that have a risk of carcinogenesis. The microenvironment is closely related to carcinogenesis and cancer progression by regulating the immune response, cell metabolic activities, and mechanical characteristics. Meanwhile, there are extensive interactions between the microenvironments that remodel and provide favorable conditions for cancer initiation. However, the changes, exact roles, and interactions of microenvironments during the carcinogenesis of OPMDs have not been fully elucidated. Here, w

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Kim, Jisoo, Jinah Jang, and Dong-Woo Cho. "Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine." Micromachines 12, no. 9 (2021): 1122. http://dx.doi.org/10.3390/mi12091122.

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The complex and heterogenous nature of cancer contributes to the development of cancer cell drug resistance. The construction of the cancer microenvironment, including the cell–cell interactions and extracellular matrix (ECM), plays a significant role in the development of drug resistance. Traditional animal models used in drug discovery studies have been associated with feasibility issues that limit the recapitulation of human functions; thus, in vitro models have been developed to reconstruct the human cancer system. However, conventional two-dimensional and three-dimensional (3D) in vitro c

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Cacciatore, Matilde, Carla Guarnotta, Marco Calvaruso, et al. "Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas." Advances in Hematology 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/138079.

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Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process. The cancer-associated microenvironment is a complex network of nonneoplastic immune and stromal cells embedded in extracellular components, giving rise to a multifarious crosstalk with neoplastic cells towards

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Faurobert, Eva, Anne-Pascale Bouin, and Corinne Albiges-Rizo. "Microenvironment, tumor cell plasticity, and cancer." Current Opinion in Oncology 27, no. 1 (2015): 64–70. http://dx.doi.org/10.1097/cco.0000000000000154.

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Blaylock, Russell L. "Viruses and tumor cell microenvironment: A brief summary." Surgical Neurology International 10 (August 9, 2019): 160. http://dx.doi.org/10.25259/sni_351_2019.

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An infectious etiology for a number of cancers has been entertained for over 100 years and modern studies have confirmed that a number of viruses are linked to cancer induction. While a large number of viruses have been demonstrated in a number of types of cancers, most such findings have been dismissed in the past as opportunistic infections, especially with persistent viruses with high rates of infectivity of the world’s populations. More recent studies have clearly shown that while not definitely causing these cancers, these viruses appear capable of affecting the biology of these tumors in

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Saab, Juan J. Apiz, Lindsey N. Dzierozynski, Patrick B. Jonker, et al. "Abstract B003: Pancreatic cancer cells activate arginine biosynthesis to adapt to myeloid-driven amino acid stress in the tumor microenvironment." Cancer Research 82, no. 22_Supplement (2022): B003. http://dx.doi.org/10.1158/1538-7445.panca22-b003.

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Abstract Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs to maintain survival and proliferation. Therefore, knowledge of microenvironmental nutrient levels and how cancer cells cope with such nutrition is critical to understand the metabolism underpinning cancer cell biology. Previously, we performed quantitative metabolomics of the interstitial fluid (the local perfusate) of pancreatic ductal adenocarcinoma (PDAC) tumors to comprehensively characterize nutrient availability in the microenvironment of these tumors. We have used this info

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Matarrese, Paola, Rosa Vona, Barbara Ascione, Camilla Cittadini, Annalisa Tocci, and Anna Maria Mileo. "Tumor Microenvironmental Cytokines Drive NSCLC Cell Aggressiveness and Drug-Resistance via YAP-Mediated Autophagy." Cells 12, no. 7 (2023): 1048. http://dx.doi.org/10.3390/cells12071048.

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Dynamic reciprocity between cellular components of the tumor microenvironment and tumor cells occurs primarily through the interaction of soluble signals, i.e., cytokines produced by stromal cells to support cancer initiation and progression by regulating cell survival, differentiation and immune cell functionality, as well as cell migration and death. In the present study, we focused on the analysis of the functional response of non-small cell lung cancer cell lines elicited by the treatment with some crucial stromal factors which, at least in part, mimic the stimulus exerted in vivo on tumor

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Cervantes-Valencia, Jesus Lizbeth, and Robert M. Kao. "From Cancer Microenvironment to Myofibroblasts." American Biology Teacher 85, no. 1 (2023): 12–16. http://dx.doi.org/10.1525/abt.2023.85.1.12.

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One of the important mechanisms in cancer cell metastasis is the cellular function of a specific cell type called myofibroblast cells. Myofibroblast cells are unique cell types that play an important role in the cancer cell microenvironment. As a step toward integrating the latest peer-reviewed cancer research findings into a general biology remote learning setting, we developed an innovative guest speaker talk to engage first-year undergraduates to develop a prediction on tumor microenvironment. In our article, we describe integrated remote approaches using Jamboard and reflective mentoring t

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Huntsman, David. "Abstract IA008: Rare ovarian cancers: the sequelae of specific interactions between cell contexts mutations and microenvironments." Cancer Research 84, no. 5_Supplement_2 (2024): IA008. http://dx.doi.org/10.1158/1538-7445.ovarian23-ia008.

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Abstract There are many pathologically and clinically distinct types of ovarian cancer and uterine cancers. These are not flavors of the same disease nor can they be solely explained by different mutations or other genomic findings; rather each may be thought to represent distinct interactions between cells of origin, mutations, and the microenvironment in which these cancers occur. Although many know gaps remain this may explain many curious features of these cancers. Fors instance, how endometrioid and clear cell carcinomas have similar mutations yet are distinct biologic and clinical entiti

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Figy, Christopher, Anna Guo, Veani Roshale Fernando, Saori Furuta, Fahd Al-Mulla, and Kam C. Yeung. "Changes in Expression of Tumor Suppressor Gene RKIP Impact How Cancers Interact with Their Complex Environment." Cancers 15, no. 3 (2023): 958. http://dx.doi.org/10.3390/cancers15030958.

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Tumor microenvironment (TME) is the immediate environment where cancer cells reside in a tumor. It is composed of multiple cell types and extracellular matrix. Microenvironments can be restrictive or conducive to the progression of cancer cells. Initially, microenvironments are suppressive in nature. Stepwise accumulation of mutations in oncogenes and tumor suppressor genes enables cancer cells to acquire the ability to reshape the microenvironment to advance their growth and metastasis. Among the many genetic events, the loss-of-function mutations in tumor suppressor genes play a pivotal role

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Shin, Eunah, and Ja Seung Koo. "Cell Component and Function of Tumor Microenvironment in Thyroid Cancer." International Journal of Molecular Sciences 23, no. 20 (2022): 12578. http://dx.doi.org/10.3390/ijms232012578.

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Thyroid cancer is the most common cancer in the endocrine system. Most thyroid cancers have good prognosis, but some of them are resistant to treatment or show aggressive behavior. Like other tumors, thyroid cancers harbor tumor microenvironment (TME) composed of cancer associated fibroblasts (CAF) and immune cells. Autoimmune lymphocytic thyroiditis can occur in the thyroid, and it may be associated with cancer development. TME is involved in tumor progression through various mechanisms: (1) CAF is involved in tumor progression through cell proliferation and extracellular matrix (ECM) remodel

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Pasquier, Jennifer, and Arash Rafii. "Role of the Microenvironment in Ovarian Cancer Stem Cell Maintenance." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/630782.

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Despite recent progresses in cancer therapy and increased knowledge in cancer biology, ovarian cancer remains a challenging condition. Among the latest concepts developed in cancer biology, cancer stem cells and the role of microenvironment in tumor progression seem to be related. Indeed, cancer stem cells have been described in several solid tumors including ovarian cancers. These particular cells have the ability to self-renew and reconstitute a heterogeneous tumor. They are characterized by specific surface markers and display resistance to therapeutic regimens. During development, specific

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Pein, Maren, and Thordur Oskarsson. "Microenvironment in metastasis: roadblocks and supportive niches." American Journal of Physiology-Cell Physiology 309, no. 10 (2015): C627—C638. http://dx.doi.org/10.1152/ajpcell.00145.2015.

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In many cancers, malignant cells can spread from the primary tumor through blood circulation and initiate metastasis in secondary organs. Metastatic colonization may depend not only on inherent properties of cancer cells, but also on suitable microenvironments in distant sites. Increasing evidence suggests that the nature of the microenvironment may determine the fate of disseminated cancer cells, providing either hindrance or support for cancer cell propagation. This can result in strong selective pressure where the vast majority of cancer cells, invading a secondary organ, are either elimina

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Thienger, Phillip, and Mark A. Rubin. "Prostate cancer hijacks the microenvironment." Nature Cell Biology 23, no. 1 (2021): 3–5. http://dx.doi.org/10.1038/s41556-020-00616-3.

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Thienger, Phillip, and Mark A. Rubin. "Prostate cancer hijacks the microenvironment." Nature Cell Biology 23, no. 1 (2021): 3–5. http://dx.doi.org/10.1038/s41556-020-00616-3.

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Madden, Matthew Z., Bradley I. Reinfeld, Melissa M. Wolf, et al. "Nutrient partitioning in the tumor microenvironment." Journal of Immunology 206, no. 1_Supplement (2021): 56.06. http://dx.doi.org/10.4049/jimmunol.206.supp.56.06.

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Abstract The tumor microenvironment (TME) includes cancer and infiltrating immune cells. Tumors canonically consume glucose through Warburg metabolism, a process forming the basis of cancer imaging by positron emission tomography (PET). Activated immune cells also rely on glucose, and impaired immune cell metabolism in the TME contributes to tumor progression. It remains uncertain, however, if immune cell metabolism is dysregulated in the TME by cell intrinsic programs or by competition with cancer cells for limiting nutrients. Here we used PET tracers to measure access and uptake of glucose a

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Casson, Jake, Owen G. Davies, Carol-Anne Smith, Matthew J. Dalby, and Catherine C. Berry. "Mesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy." Journal of Tissue Engineering 9 (January 2018): 204173141881009. http://dx.doi.org/10.1177/2041731418810093.

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Disseminated breast cancer cells have the capacity to metastasise to the bone marrow and reside in a dormant state within the mesenchymal stem cell niche. Research has focussed on paracrine signalling factors, such as soluble proteins, within the microenvironment. However, it is now clear extracellular vesicles secreted by resident mesenchymal stem cells into this microenvironment also play a key role in the initiation of dormancy. Dormancy encourages reduced cell proliferation and migration, while upregulating cell adhesion, thus retaining the cancer cells within the bone marrow microenvironm

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Arneth, Borros. "Tumor Microenvironment." Medicina 56, no. 1 (2019): 15. http://dx.doi.org/10.3390/medicina56010015.

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Background and Objectives: The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer. In addition, nonmalignant cells in the tumor microenvironment play critical roles in all the stages of carcinogenesis by stimulating and facilitating uncontrolled cell proliferation. Aim: This study aims to explore the concept of the tumor microenvironment by conducting a critical review of previous studies on the topic. Materials

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Dobaño-López, Cèlia, Ferran Araujo-Ayala, Neus Serrat, Juan G. Valero, and Patricia Pérez-Galán. "Follicular Lymphoma Microenvironment: An Intricate Network Ready for Therapeutic Intervention." Cancers 13, no. 4 (2021): 641. http://dx.doi.org/10.3390/cancers13040641.

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Follicular Lymphoma (FL), the most common indolent non-Hodgkin’s B cell lymphoma, is a paradigm of the immune microenvironment’s contribution to disease onset, progression, and heterogeneity. Over the last few years, state-of-the-art technologies, including whole-exome sequencing, single-cell RNA sequencing, and mass cytometry, have precisely dissected the specific cellular phenotypes present in the FL microenvironment network and their role in the disease. In this already complex picture, the presence of recurring mutations, including KMT2D, CREBBP, EZH2, and TNFRSF14, have a prominent contri

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Shi, Xiaokai, Xiao Zhou, Chuang Yue, et al. "A Five Collagen-Related Gene Signature to Estimate the Prognosis and Immune Microenvironment in Clear Cell Renal Cell Cancer." Vaccines 9, no. 12 (2021): 1510. http://dx.doi.org/10.3390/vaccines9121510.

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Collagen is the main component of the extracellular matrix (ECM) and might play an important role in tumor microenvironments. However, the relationship between collagen and clear cell renal cell cancer (ccRCC) is still not fully clarified. Hence, we aimed to establish a collagen-related signature to predict the prognosis and estimate the tumor immune microenvironment in ccRCC patients. Patients with a high risk score were often correlated with unfavorable overall survival (OS) and an immunosuppressive microenvironment. In addition, the collagen-related genetic signature was highly correlated w

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Bronevetsky, Yelena, Evan Massi, Candy Garcia, et al. "Abstract 1782: Functional potency assay predicts CAR-T effectiveness in tumor microenvironment." Cancer Research 83, no. 7_Supplement (2023): 1782. http://dx.doi.org/10.1158/1538-7445.am2023-1782.

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Abstract Chimeric antigen receptor (CAR) T cell therapy holds great promise for the treatment of various cancers, including solid tumors. However, attempts to model the behavior and effectiveness of CAR-T cell therapies for blood cancers and solid tumors have been challenging due to the unique tumor microenvironments in which these cancer cells are found. The tumor microenvironment (TME) is often characterized by hypoxia, increased acidity, and high interstitial fluid pressures, allowing cancer cells to effectively evade immune surveillance. This immunosuppressive TME also contributes to CAR-T

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Rao, Rohit, Feng Zhang, Ravinder Verma, Jincheng Wang, Dazhuan Xin, and Richard Lu. "TMIC-55. CHARACTERIZATION OF TUMOR-MICROENVIRONMENT INTERACTIONS IN GLIOBLASTOMAS AT THE SINGLE-CELL LEVEL." Neuro-Oncology 21, Supplement_6 (2019): vi259—vi260. http://dx.doi.org/10.1093/neuonc/noz175.1089.

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Abstract Glioblastomas are malignant brain tumors that carry a poor prognosis. The tumor microenvironment has been identified as an important regulator of tumor growth and may represent a novel target for therapy. Transcriptional subtypes of glioma are a major source of heterogeneity of expression in gliomas. Gliomas are highly heterogeneous diseases and can be classified into different subtypes including proneural, classical and mesenchymal tumors. We hypothesized that different subtypes of glioma will have different microenvironmental composition and exhibit distinct responses to therapies.

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Devarasetty, Mahesh, Samuel Herberg, Anthony Dominijanni, Ethan Willey-Shelkey, Aleksander Skardal, and Shay Soker. "Biofabricated tumor microenvironments for studying colorectal cancer in vitro and in vivo." Journal of Clinical Oncology 37, no. 15_suppl (2019): e14689-e14689. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14689.

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e14689 Background: Microenvironmental mechanics have a tremendous effect on the progression, phenotype, and therapeutic response of cancer cells positioning it as a high-potential target for novel therapeutic development. Laboratory modeling of the microenvironment and its multitude of effects is imperative for developing new avenues of anti-cancer therapy that can target non-traditional vectors such as the extracellular matrix (ECM) and stromal cells. Researchers have developed in vitro models of the tumor microenvironment (TME) to meet this need. While in vitro modeling is an important step

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Kim, Go Woon, Dong Hoon Lee, Yu Hyun Jeon, et al. "Glutamine Synthetase as a Therapeutic Target for Cancer Treatment." International Journal of Molecular Sciences 22, no. 4 (2021): 1701. http://dx.doi.org/10.3390/ijms22041701.

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The significance of glutamine in cancer metabolism has been extensively studied. Cancer cells consume an excessive amount of glutamine to facilitate rapid proliferation. Thus, glutamine depletion occurs in various cancer types, especially in poorly vascularized cancers. This makes glutamine synthetase (GS), the only enzyme responsible for de novo synthesizing glutamine, essential in cancer metabolism. In cancer, GS exhibits pro-tumoral features by synthesizing glutamine, supporting nucleotide synthesis. Furthermore, GS is highly expressed in the tumor microenvironment (TME) and provides glutam

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Cognet, Guillaume, Colin Sheehan, Grace Croley, Lyndon Hu, and Alexander Muir. "Abstract PR14: Ex vivo models of pancreatic cancer that recapitulate the metabolic tumor microenvironment identify glycine as a chemoresistance-inducing oncometabolite." Cancer Research 84, no. 2_Supplement (2024): PR14. http://dx.doi.org/10.1158/1538-7445.panca2023-pr14.

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Abstract Pancreatic adenocarcinoma (PDAC) tumors are poorly perfused due to intense desmoplasia and dysfunctional vasculature. This limited perfusion leads to abnormal availability of nutrients and metabolic substrates in the tumor microenvironment. To understand how microenvironmetnal nutrient availability impacts PDAC biology, we performed quantitative metabolomics of the interstitial fluid (the local perfusate) of PDAC tumors to comprehensively characterize nutrient availability in the PDAC microenvironment. We have used this information to develop Tumor Interstitial Fluid Medium (TIFM), a

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Ghotra, Veerander P. S., Jordi C. Puigvert, and Erik H. J. Danen. "The cancer stem cell microenvironment and anti-cancer therapy." International Journal of Radiation Biology 85, no. 11 (2009): 955–62. http://dx.doi.org/10.3109/09553000903242164.

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Golebiewska, Anna, Anne Dirkse, Thomas Buder, et al. "STEM-09. INTRINSIC TUMOR PLASTICITY IN GLIOBLASTOMA ALLOWS FOR RECREATION OF STEM LIKE-STATES AND EFFICIENT TUMOR CELL ADAPTATION TO NEW MICROENVIRONMENTS." Neuro-Oncology 21, Supplement_6 (2019): vi235. http://dx.doi.org/10.1093/neuonc/noz175.983.

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Abstract BACKGROUND Cellular heterogeneity is a hallmark of numerous cancer types, including Glioblastoma (GBM). Cancer stem cells (CSC) have been accounted for the generation of phenotypic heterogeneity and tumor progression in GBM. Recent data, however, suggest that CSCs may not represent a stable entity and intrinsic plasticity plays a key role in tumor adaptation to changing microenvironments. The question arises whether CSCs are a defined subpopulation of GBM or whether they represent a cellular state that any cancer cell can adopt. METHODS We interrogated intra-tumoral phenotypic heterog

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Shalek, Alex K. "Abstract IA007: Does cancer cell state matter? Moving from DNA genotype to RNA phenotype-directed therapies in cancer." Cancer Research 82, no. 22_Supplement (2022): IA007. http://dx.doi.org/10.1158/1538-7445.panca22-ia007.

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Abstract Recent advances in high throughput genomic sequencing technologies have led to a detailed understanding of the genetic alterations that underlie human tumors. However, evidence increasingly indicates that using mutations alone to assign therapies has its limitations, even for cancers with actionable mutational heterogeneity. The advent of single-cell genomic technologies has confirmed extensive mutational heterogeneity in human tumors but also revealed that the complexity of cancer extends to variation in cell transcriptional state. Deciphering whether transcriptional variation inform

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Wieder, Robert. "Fibroblasts as Turned Agents in Cancer Progression." Cancers 15, no. 7 (2023): 2014. http://dx.doi.org/10.3390/cancers15072014.

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Differentiated epithelial cells reside in the homeostatic microenvironment of the native organ stroma. The stroma supports their normal function, their G0 differentiated state, and their expansion/contraction through the various stages of the life cycle and physiologic functions of the host. When malignant transformation begins, the microenvironment tries to suppress and eliminate the transformed cells, while cancer cells, in turn, try to resist these suppressive efforts. The tumor microenvironment encompasses a large variety of cell types recruited by the tumor to perform different functions,

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Kim, Yuri, Qun Lin, Peter Glazer, and Zhong Yun. "Hypoxic Tumor Microenvironment and Cancer Cell Differentiation." Current Molecular Medicine 9, no. 4 (2009): 425–34. http://dx.doi.org/10.2174/156652409788167113.

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Kan, Casina, Geoffrey Vargas, François Pape, and Philippe Clézardin. "Cancer Cell Colonisation in the Bone Microenvironment." International Journal of Molecular Sciences 17, no. 10 (2016): 1674. http://dx.doi.org/10.3390/ijms17101674.

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Mier, James W. "The tumor microenvironment in renal cell cancer." Current Opinion in Oncology 31, no. 3 (2019): 194–99. http://dx.doi.org/10.1097/cco.0000000000000512.

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Agrawal, Ayushi, Somayeh Shahreza, Yousef Javanmardi, Nicolas Szita, and Emad Moeendarbary. "The tumour microenvironment modulates cancer cell intravasation." Organs-on-a-Chip 4 (December 2022): 100024. http://dx.doi.org/10.1016/j.ooc.2022.100024.

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Lau, Allison N., and Matthew G. Vander Heiden. "Metabolism in the Tumor Microenvironment." Annual Review of Cancer Biology 4, no. 1 (2020): 17–40. http://dx.doi.org/10.1146/annurev-cancerbio-030419-033333.

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Experiments in culture systems where one cell type is provided with abundant nutrients and oxygen have been used to inform much of our understanding of cancer metabolism. However, many differences have been observed between the metabolism of tumors and the metabolism of cancer cells grown in monoculture. These differences reflect, at least in part, the presence of nonmalignant cells in the tumor microenvironment and the interactions between those cells and cancer cells. However, less is known about how the metabolism of various tumor stromal cell types differs from that of cancer cells, and ho

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Ciardiello, Chiara, Alessandra Leone, and Alfredo Budillon. "The Crosstalk between Cancer Stem Cells and Microenvironment Is Critical for Solid Tumor Progression: The Significant Contribution of Extracellular Vesicles." Stem Cells International 2018 (November 5, 2018): 1–11. http://dx.doi.org/10.1155/2018/6392198.

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Several evidences nowadays demonstrated the critical role of the microenvironment in regulating cancer stem cells and their involvement in tumor progression. Extracellular vesicles (EVs) are considered as one of the most effective vehicles of information among cells. Accordingly, a number of studies led to the recognition of stem cell-associated EVs as new complexes able to contribute to cell fate determination of either normal or tumor cells. In this review, we aim to highlight an existing bidirectional role of EV-mediated communication—from cancer stem cells to microenvironment and also from

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Sim, Jooyoung, Hyun Jung Lee, Byeongmoon Jeong, and Min Hee Park. "Poly(Ethylene Glycol)-Poly(l-Alanine)/Hyaluronic Acid Complex as a 3D Platform for Understanding Cancer Cell Migration in the Tumor Microenvironment." Polymers 13, no. 7 (2021): 1042. http://dx.doi.org/10.3390/polym13071042.

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Cancer progression and migration in the tumor microenvironment are related to cell types and three-dimensional (3D) matrices. Therefore, developing biomimetic tumor models, including co-culture systems and a tunable 3D matrix, could play an essential role in understanding the cancer environment. Here, multicellular spheroids using human adipose-derived mesenchymal stem cells (hADSCs) and breast cancer cells (MDA-MB-231) within the 3D matrix were used as a tumor microenvironment (TME) mimicking platform. The amphiphilic peptide block copolymer and hyaluronic acid (HA) formed a self-assembled st

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Ye, Jiaan, Longgang Cui, Xiaochen Zhao, and Guanghui Lan. "Comparing of pan-cancer tumor immune microenvironment." Journal of Clinical Oncology 39, no. 15_suppl (2021): e15100-e15100. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15100.

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e15100 Background: Cancer treatment has entered the era of immune checkpoint inhibitors (ICI), but different tumors have different responses to ICI drugs. For example, non-small cell lung cancer and melanoma have higher response rates to ICIs than colorectal cancer and liver cancer patients. Previous studies have shown that tumor immune microenvironment have a great impact on the efficacy of ICI. Methods: This study retrospectively included pan-cancer patient specimens, using multiple fluorescent labeling immunohistochemistry to explore the differences in the immune microenvironment of differe

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Plzák, Jan, Jan Bouček, Veronika Bandúrová, et al. "The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy." Cancers 11, no. 4 (2019): 440. http://dx.doi.org/10.3390/cancers11040440.

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Similarly to other types of malignant tumours, the incidence of head and neck cancer is increasing globally. It is frequently associated with smoking and alcohol abuse, and in a broader sense also with prolonged exposure to these factors during ageing. A higher incidence of tumours observed in younger populations without a history of alcohol and tobacco abuse may be due to HPV infection. Malignant tumours form an intricate ecosystem of cancer cells, fibroblasts, blood/lymphatic capillaries and infiltrating immune cells. This dynamic system, the tumour microenvironment, has a significant impact

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Prashantha, Kalappa, Amita Krishnappa, and Malini Muthappa. "3D bioprinting of gastrointestinal cancer models: A comprehensive review on processing, properties, and therapeutic implications." Biointerphases 18, no. 2 (2023): 020801. http://dx.doi.org/10.1116/6.0002372.

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Gastrointestinal tract (GIT) malignancies are an important public health problem considering the increased incidence in recent years and the high morbidity and mortality associated with it. GIT malignancies constitute 26% of the global cancer incidence burden and 35% of all cancer-related deaths. Gastrointestinal cancers are complex and heterogenous diseases caused by the interplay of genetic and environmental factors. The tumor microenvironment (TME) of gastrointestinal tract carcinomas is dynamic and complex; it cannot be recapitulated in the basic two-dimensional cell culture systems. In co

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