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Letteratura scientifica selezionata sul tema "Cell interaction"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 29 luglio 2024

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Articoli di riviste sul tema "Cell interaction"

1

Brückner, David B., Nicolas Arlt, Alexandra Fink, Pierre Ronceray, Joachim O. Rädler, and Chase P. Broedersz. "Learning the dynamics of cell–cell interactions in confined cell migration." Proceedings of the National Academy of Sciences 118, no. 7 (February 12, 2021): e2016602118. http://dx.doi.org/10.1073/pnas.2016602118.

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The migratory dynamics of cells in physiological processes, ranging from wound healing to cancer metastasis, rely on contact-mediated cell–cell interactions. These interactions play a key role in shaping the stochastic trajectories of migrating cells. While data-driven physical formalisms for the stochastic migration dynamics of single cells have been developed, such a framework for the behavioral dynamics of interacting cells still remains elusive. Here, we monitor stochastic cell trajectories in a minimal experimental cell collider: a dumbbell-shaped micropattern on which pairs of cells perf

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2

Ogushi, Fumiko, and Hiroshi Kori. "3P277 Dependence of cell differentiation ratio on cell-cell interaction and noise(24. Mathematical biology,Poster)." Seibutsu Butsuri 53, supplement1-2 (2013): S257. http://dx.doi.org/10.2142/biophys.53.s257_6.

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3

Chesterton, C. J. "Cell to cell interaction." FEBS Letters 293, no. 1-2 (November 1, 1991): 229. http://dx.doi.org/10.1016/0014-5793(91)81201-i.

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4

Manimaran, K., Arun Kumar, AvinashGandi D, and S. Sankaranarayanan. "Interaction of Human Dental Pulp Stem Cells and Ameloblastic Cell In-vitro- A Preclinical Analysis." Annals of Oral Health and Dental Research 2, no. 1 (January 17, 2018): A1–5. http://dx.doi.org/10.21276/aohdr.1831.

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5

Oropesa-Nuñez, Reinier, Andrea Mescola, Massimo Vassalli, and Claudio Canale. "Impact of Experimental Parameters on Cell–Cell Force Spectroscopy Signature." Sensors 21, no. 4 (February 4, 2021): 1069. http://dx.doi.org/10.3390/s21041069.

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Atomic force microscopy is an extremely versatile technique, featuring atomic-scale imaging resolution, and also offering the possibility to probe interaction forces down to few pN. Recently, this technique has been specialized to study the interaction between single living cells, one on the substrate, and a second being adhered on the cantilever. Cell–cell force spectroscopy offers a unique tool to investigate in fine detail intra-cellular interactions, and it holds great promise to elucidate elusive phenomena in physiology and pathology. Here we present a systematic study of the effect of th

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Hwang, Inkyu, Jing-Feng Huang, Hidehiro Kishimoto, Anders Brunmark, Per A. Peterson, Michael R. Jackson, Charles D. Surh, Zeling Cai, and Jonathan Sprent. "T Cells Can Use Either T Cell Receptor or Cd28 Receptors to Absorb and Internalize Cell Surface Molecules Derived from Antigen-Presenting Cells." Journal of Experimental Medicine 191, no. 7 (March 27, 2000): 1137–48. http://dx.doi.org/10.1084/jem.191.7.1137.

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At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)–peptide–major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte function-associated antigen 1 (LFA-1) on T cells interacting with B7 (B7-1 and B7-2), and intracellular adhesion molecule 1 (ICAM-1), respectively, on APCs. Here, we show that during T cell–APC interaction, T cells rapidly absorb various molecules from APCs onto the cell membrane and then internalize these molecules. This process is dictated by at least

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7

Yuan, Ye, Carlos Cosme, Taylor Sterling Adams, Jonas Schupp, Koji Sakamoto, Nikos Xylourgidis, Matthew Ruffalo, Jiachen Li, Naftali Kaminski, and Ziv Bar-Joseph. "CINS: Cell Interaction Network inference from Single cell expression data." PLOS Computational Biology 18, no. 9 (September 12, 2022): e1010468. http://dx.doi.org/10.1371/journal.pcbi.1010468.

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Studies comparing single cell RNA-Seq (scRNA-Seq) data between conditions mainly focus on differences in the proportion of cell types or on differentially expressed genes. In many cases these differences are driven by changes in cell interactions which are challenging to infer without spatial information. To determine cell-cell interactions that differ between conditions we developed the Cell Interaction Network Inference (CINS) pipeline. CINS combines Bayesian network analysis with regression-based modeling to identify differential cell type interactions and the proteins that underlie them. W

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8

Okuyama, Akihiko. "INTRATESTICULAR CELL TO CELL INTERACTION." Japanese Journal of Urology 83, no. 7 (1992): 1027–35. http://dx.doi.org/10.5980/jpnjurol1989.83.1027.

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Yamasaki, Hiroshi. "Cell-Cell Interaction and Carcinogenesis." Toxicologic Pathology 14, no. 3 (April 1986): 363–69. http://dx.doi.org/10.1177/019262338601400313.

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Lin, Yingxin, Lipin Loo, Andy Tran, David M. Lin, Cesar Moreno, Daniel Hesselson, G. Gregory Neely, and Jean Y. H. Yang. "Scalable workflow for characterization of cell-cell communication in COVID-19 patients." PLOS Computational Biology 18, no. 10 (October 5, 2022): e1010495. http://dx.doi.org/10.1371/journal.pcbi.1010495.

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COVID-19 patients display a wide range of disease severity, ranging from asymptomatic to critical symptoms with high mortality risk. Our ability to understand the interaction of SARS-CoV-2 infected cells within the lung, and of protective or dysfunctional immune responses to the virus, is critical to effectively treat these patients. Currently, our understanding of cell-cell interactions across different disease states, and how such interactions may drive pathogenic outcomes, is incomplete. Here, we developed a generalizable and scalable workflow for identifying cells that are differentially i

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Più fonti

Tesi sul tema "Cell interaction"

1

Wong, Ching-hang. "Cell-cell interactions and cell junction dynamics in the mammalian testis." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31993084.

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Kim, Sung Kyu. "Endothelial cell interaction with collagen." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709002.

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Wong, Ching-hang, and 黃政珩. "Cell-cell interactions and cell junction dynamics in the mammalian testis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31993084.

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Kavikondala, Sushma. "Dendritic cell and B cell interactions in systemic lupuserythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39793710.

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5

Wright, Kierra D. "Chiral polymer surface-cell interaction: understanding the role of chirality & surface topography on polymer-cell interactions." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2012. http://digitalcommons.auctr.edu/dissertations/436.

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Abstract (sommario):

Understanding surface-cell interactions is essential to fabricating a successful biomaterial. In vivo, cells interact with asymmetric features on the micro- and nanoscale. Some of these features, described as valleys, ridges, and spheres, are random, but methodically placed. There are many techniques used to duplicate the topographical features that cells encounter, many of which rely on precision and are labor intensive. Alternatively, the synthetic poly(2-methoxystyrene) (P2MS) homopolymer selfassembled into desirable features, was easily processed and produced the random surface preferred b

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Miller, Christina Roshek 1969. "Photosensitive liposome-cell interaction in vitro." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/288913.

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Bennett and O'Brien [Biochemistry 1995 34, 3102] showed that the ultraviolet light exposure of two-component large unilamellar liposomes (LUV) composed of a 3:1 molar mixture of dioleoylphosphatidylethanolamine (DOPE) and 1,2-bis[10-(2'-hexadienoyloxy)-decanoyl]-sn-glycero-3-phosphatidylcholine (bis-SorbPC) facilitated liposome fusion. The rate and extent of fusion was dependent on the extent of photopolymerization, the temperature, and the pH. Here, the effect of the molar lipid ratio of DOPE/bis-SorbPC liposomes on the temperature for the onset of fusion, was characterized by changing the r

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Nam, Hye In. "Multiplexed fragmentation and protein interaction reporter technology application to human cells." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Summer2009/h_nam_071509.pdf.

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Thesis (M.S. in Chemistry)--Washington State University, August 2009.<br>Title from PDF title page (viewed on Sept. 21, 2009). "Department of Chemistry." Includes bibliographical references (p. 60-66).

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Rezaei, Nima. "B-Cell and T-Cell interaction in common variable immunodeficiency." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512017.

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Zeytun, Ahmet. "Tumor cell-immune cell interaction: A lethal two way street." Diss., Virginia Tech, 1999. http://hdl.handle.net/10919/27905.

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We investigated the role of Fas ligand in the development of anti-tumor immunity. The LSA tumor specific cytotoxic T lymphocyte (CTL) clone, PE-9, expressed both Fas and Fas ligand. This CTL clone upregulated Fas and Fas ligand expression upon activation through the T-cell receptor and induced apoptosis in Fas+, LSA tumor cells using the FasL-based pathway. However, LSA and EL-4 tumor cells constitutively expressed Fas ligand and killed Fas+ PE-9 CTLs and Fas+, but not Fas-negative (Fas-) activated T cells and thymocytes. These data suggested that T cells and cancer cells can kill each other

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Kavikondala, Sushma. "Dendritic cell and B cell interactions in systemic lupus erythematosus." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39711523.

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Libri sul tema "Cell interaction"

1

Martin, Dworkin, ed. Microbial cell-cell interactions. Washington, D.C: American Society for Microbiology, 1991.

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2

Sayers, Nicola MacDonald. Fibroblast-endothelial cell interaction. Manchester: University of Manchester, 1993.

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3

C, De Mello Walmor, ed. Cell intercommunication. Boca Raton, Fla: CRC Press, 1989.

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4

1936-, Gerhart John, ed. Cell-cell interactions in early development. New York: Wiley-Liss, 1991.

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5

Colloque d'animation de la recherche INSERM (2nd 1986). Communication cellulaire & pathologie. Paris: INSERM, 1988.

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Morgan, Noel G. Cell signalling. Milton Keynes [England]: Open University Press, 1989.

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7

Russell, Stevenson Bruce, Gallin Warren J, and Paul David Louis, eds. Cell-cell interactions: A practical approach. Oxford: IRL Press at Oxford University Press, 1992.

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C, De Mello Walmor, ed. Cell intercommunication. Boca Raton, Fla: CRC Press, 1990.

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9

Johnson, A. Wagoner. Mechanobiology of Cell-Cell and Cell-Matrix Interactions. Boston, MA: Springer Science+Business Media, LLC, 2011.

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10

K, Messmer, ed. Capillary functions and white cell interaction. Basel: Karger, 1991.

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Capitoli di libri sul tema "Cell interaction"

1

Wirth, Reinhard. "Prokaryotic Cell–Cell Interaction." In Prokaryotic Cell Wall Compounds, 409–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-05062-6_14.

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Deutsch, Andreas, and Sabine Dormann. "Adhesive Cell Interaction." In Cellular Automaton Modeling of Biological Pattern Formation, 159–83. Boston, MA: Birkhäuser Boston, 2017. http://dx.doi.org/10.1007/978-1-4899-7980-3_7.

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3

Buitrago, Jennifer O., Begoña M. Bosch, and Román A. Pérez. "Cell-Materials Interaction." In Stem Cell Biology and Regenerative Medicine, 239–58. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-35832-6_8.

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Feinstein, Timothy N. "Cell-Surface Protein–Protein Interaction Analysis with Time-Resolved FRET and Snap-Tag Technologies." In Cell-Cell Interactions, 121–29. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-604-7_11.

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Gabison, Eric, Farah Khayati, Samia Mourah, and Suzanne Menashi. "Cell Membrane Vesicles as a Tool for the Study of Direct Epithelial–Stromal Interaction: Lessons from CD147." In Cell-Cell Interactions, 103–11. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-604-7_9.

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Lucas, W. J., S. Wolf, C. M. Deom, G. M. Kishore, and R. N. Beachy. "Plasmodesmata - Virus Interaction." In Parallels in Cell to Cell Junctions in Plants and Animals, 261–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-83971-9_18.

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Pavelka, Margit, and Jürgen Roth. "Selectin — Ligand-Mediated Cell-Cell Interaction." In Functional Ultrastructure, 174–75. Vienna: Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-211-99390-3_91.

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Hayes, J. S., E. M. Czekanska, and R. G. Richards. "The Cell–Surface Interaction." In Tissue Engineering III: Cell - Surface Interactions for Tissue Culture, 1–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/10_2011_110.

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Balfour, B. M., L. Buttifant, J. O’Brien, J. Clarke, and S. C. Knight. "Veiled Cell Lymphocyte Interaction." In Microenvironments in the Lymphoid System, 395–99. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2463-8_48.

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Sazeides, Christos, and Anne Le. "Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells." In The Heterogeneity of Cancer Metabolism, 189–204. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65768-0_14.

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AbstractCancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and metastasis. Recent findings have demonstrated that the TME not only provides physical support for cancer cells but also directs cell-to-cell interactions (in this case, the interaction between cancer cells and CAFs). As cancer progresses, the CAFs also coevolve, transitioning from an inactivated state to an activated state. The elucidation and understanding of the interaction between cancer cells and CAFs will pave the way for new cancer therapies [1–3].

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Atti di convegni sul tema "Cell interaction"

1

Reynaud, J. A., A. Brack, J. P. Grivet, and Y. Trudelle. "Interaction of phospholipids with basic amphiphilic polypeptides." In The living cell in four dimensions. AIP, 1991. http://dx.doi.org/10.1063/1.40574.

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Shi, Xing. "Numerical analysis on cell-cell interaction of red blood cells during sedimentation." In INTERNATIONAL CONFERENCE OF NUMERICAL ANALYSIS AND APPLIED MATHEMATICS (ICNAAM 2016). Author(s), 2017. http://dx.doi.org/10.1063/1.4992731.

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3

Yuan, Wenqiao Wayne, Yan Cui, and Z. J. Pei. "Algal Cell-Surface Interaction: An Overview and Preliminary Test." In ASME 2009 International Manufacturing Science and Engineering Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/msec2009-84222.

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Five methods, namely adsorption, covalent binding, encapsulation, entrapment, and cross-linking, for algae immobilization were briefly reviewed in this article. The immobilization capabilities of four solid carrier materials (polystyrene, polyurethane, polyethylene, and cross-linked polyethylene) with two algal species (Nannochloropsis oculata and Scendesmus dimorphus) were tested. After 14 days of immobilization, polystyrene foam showed the best cell attachment and was covered by algae cells not only on the outer surface but also inside the porous spaces of the carrier. The cross-linked polye

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Donepudi,, SreeKanth, Christopher D. Porada, Esmail Zanjani, and Graça Almeida-Porada. "Abstract 538: Mesenchymal stem cell subset prevents cycling of KG1a leukemic cells by cell-cell interaction." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-538.

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Esumi, N., S. Todo, and S. Imashuku. "INTERACTION BETWEEN HEMOSTATIC COMPONENTS AND TUMOR CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643202.

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Involvement of platelets and coagulation systems in the hematogenous metastasis of tumor cells has been suggested from in vivo and in vitro studies, however, there is still controversy about the exact role of hemostasis in metastasis. To date, at least three types of platelet aggregating mechanisms and three types of tumor cell procoagulants have been reported in different tumor cells.We investigated platelet aggregating activity (PAA), procoagulant activity (PCA) and the relationship between these two activities, using eight human neuroblastoma cell lines, three human leukemia cell lines and

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Guan, Yingxue, Aili Zhang, and Lisa X. Xu. "Study of Interaction Energy Between Nanoparticles and Cell Membrane." In 2010 14th International Heat Transfer Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/ihtc14-23187.

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Applications of nanoparticles in the bio-medical field like nano-medicine, molecular imaging probes, fluorescence marker, gene carriers, are developing quickly owing to the unique characteristics of nanoparticles. Among these applications, the interaction of nano-particles with the living cells is of critical importance. The complex chemical properties and biological activities of the particles bring about undesirable cytotoxic potentials and special cell internalization. According to previous studies, the cell uptake kinetics of nanoparticles mainly depend on the concentration difference betw

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7

Hashimoto, Shigehiro, and Takashi Yokomizo. "Tracings of Interaction Between Myoblasts Under Shear Flow in Vitro." In ASME 2021 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/fedsm2021-65203.

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Abstract How does the group of cells make orientation perpendicular to the flow direction? How does contact with an adjacent cell affect the orientation of the cell? The orientation of a cell according to the neighbor cell under shear flow fields has been traced in vitro. A Couette type flow device with parallel discs was manufactured for the cell culture under the controlled constant wall shear stress. Cells (C2C12: mouse myoblast cell line) were cultured on the lower disc while applying the shear flow in the medium by the upper rotating disc. After culture for 24 hours without flow for adhes

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Yoshimori, Takashi, Masaki Fukagawa, and Hiroshi Takamatsu. "Effect of Cell-to-Surface Interaction on Freeze Tolerance and Osmotic Response of Cells." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192404.

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Cryopreservation of tissues and organs, including artificial organs, could be one of the important steps in the medical service that brings the progress in the tissue engineering to realization. In this case, high viability of cryopreserved cells is critical to recovery after transplantation. In contrast, in the cryosurgery, which is expected to expand its application as a minimally invasive treatment of cancer, malignant cells should be destructed completely to prevent from recurrence. The appropriate freeze-thaw protocol is therefore needed to be established for cryopreservation or cryosurge

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Chang, Jiyoung, Sang-Hee Yoon, Mohammad R. K. Mofrad, and Liwei Lin. "MEMS-based biological platform for dynamic cell-to-cell interaction characterization." In 2010 IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2010. http://dx.doi.org/10.1109/memsys.2010.5442559.

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Furuike, Kaori, Ai Shima, Yuya Morimoto, and Shoji Takeuchi. "Pneumatically driven PDMS micropillars for the investigation of cell-cell interaction." In 2018 IEEE Micro Electro Mechanical Systems (MEMS). IEEE, 2018. http://dx.doi.org/10.1109/memsys.2018.8346555.

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Rapporti di organizzazioni sul tema "Cell interaction"

1

Navone, Nora M. Osteoblast-Prostate Cancer Cell Interaction in Prostate Cancer Bone. Fort Belvoir, VA: Defense Technical Information Center, February 2000. http://dx.doi.org/10.21236/ada391088.

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Diaz-Meco, Maria T. Targeting the Adipocyte-Tumor Cell Interaction in Prostate Cancer Treatment. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada610957.

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Beuneu, Helene, Sandra Demaria, and Michael Dustin. Visualizing Breast Cancer Cell Interaction with Tumor-Infiltrating Lymphocytes During Immunotherapy. Fort Belvoir, VA: Defense Technical Information Center, April 2013. http://dx.doi.org/10.21236/ada577265.

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Lillard. Jr, James W. CXCL13-CXCR5 Interaction and Prostate Cancer Cell Firm Adhesion and Bone Metastasis. Fort Belvoir, VA: Defense Technical Information Center, September 2007. http://dx.doi.org/10.21236/ada484348.

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Weinberg, Andrew D. Tumor Specific CD4+ T-Cell Costimulation Through a Novel Receptor/Ligand Interaction. Fort Belvoir, VA: Defense Technical Information Center, August 1999. http://dx.doi.org/10.21236/ada374764.

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Weinberg, Andrew D. Tumor Specific CD4+ T-Cell Costimulation Through a Novel Receptor Ligand Interaction. Fort Belvoir, VA: Defense Technical Information Center, August 1998. http://dx.doi.org/10.21236/ada359629.

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Ron, Eliora, and Eugene Eugene Nester. Global functional genomics of plant cell transformation by agrobacterium. United States Department of Agriculture, March 2009. http://dx.doi.org/10.32747/2009.7695860.bard.

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The aim of this study was to carry out a global functional genomics analysis of plant cell transformation by Agrobacterium in order to define and characterize the physiology of Agrobacterium in the acidic environment of a wounded plant. We planed to study the proteome and transcriptome of Agrobacterium in response to a change in pH, from 7.2 to 5.5 and identify genes and circuits directly involved in this change. Bacteria-plant interactions involve a large number of global regulatory systems, which are essential for protection against new stressful conditions. The interaction of bacteria with

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Citovsky, Vitaly, and Yedidya Gafni. Viral and Host Cell Determinants of Nuclear Import and Export of the Tomato Yellow Leaf Curl Virus in Tomato Plants. United States Department of Agriculture, August 2002. http://dx.doi.org/10.32747/2002.7585200.bard.

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Tomato yellow leaf curl geminivirus (TYLCV) is a major pathogen of cultivated tomato, causing up to 100% crop loss in many parts of the world. In Israel, where TYLCV epidemics have been recorded since the 1960' s, this viral disease is well known and has been of economic significance ever since. In recent years, TYLCV outbreaks also occurred in the "New World" - Cuba, The Dominican Republic, and in the USA, in Florida, Georgia and Louisiana. Thus, TYLCV substantially hinders tomato growth throughout the world. Surprisingly, however, little is known about the molecular mechanisms of TYLCV inter

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Barg, Rivka, Erich Grotewold, and Yechiam Salts. Regulation of Tomato Fruit Development by Interacting MYB Proteins. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7592647.bard.

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Background to the topic: Early tomato fruit development is executed via extensive cell divisions followed by cell expansion concomitantly with endoreduplication. The signals involved in activating the different modes of growth during fruit development are still inadequately understood. Addressing this developmental process, we identified SlFSM1 as a gene expressed specifically during the cell-division dependent stages of fruit development. SlFSM1 is the founder of a class of small plant specific proteins containing a divergent SANT/MYB domain (Barg et al 2005). Before initiating this project,

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Manulis, Shulamit, Christine D. Smart, Isaac Barash, Guido Sessa, and Harvey C. Hoch. Molecular Interactions of Clavibacter michiganensis subsp. michiganensis with Tomato. United States Department of Agriculture, January 2011. http://dx.doi.org/10.32747/2011.7697113.bard.

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Clavibacter michiganensis subsp. michiganensis (Cmm), the causal agent of bacterial wilt and canker of tomato, is the most destructive bacterial disease of tomato causing substantial economic losses in Israel, the U.S.A. and worldwide. The molecular strategies that allow Cmm, a Gram-positive bacterium, to develop a successful infection in tomato plants are largely unknown. The goal of the project was to elucidate the molecular interactions between Cmmand tomato. The first objective was to analyze gene expression profiles of susceptible tomato plants infected with pathogenic and endophytic Cmms

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