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Letteratura scientifica selezionata sul tema "Chemokines"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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Articoli di riviste sul tema "Chemokines"

1

Struyf, Sofie, Paul Proost, Jean-Pierre Lenaerts, Griet Stoops, Anja Wuyts, and Jo Van Damme. "Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1." Blood 97, no. 8 (2001): 2197–204. http://dx.doi.org/10.1182/blood.v97.8.2197.

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Abstract Chemokines constitute a large family of chemotactic cytokines that selectively attract different blood cell types. Although most inflammatory chemoattractants are only induced and released in the circulation during acute infection, a restricted number of CXC and CC chemokines are constitutively present in normal plasma at high concentrations. Here, such a chemotactic protein was purified to homogeneity from serum and fully identified as a novel CC chemokine by mass spectrometry and amino acid sequence analysis. The protein, tentatively designated Regakine-1, shows less than 50% sequen

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2

Parry, Christopher M., J. Pedro Simas, Vincent P. Smith, et al. "A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus." Journal of Experimental Medicine 191, no. 3 (2000): 573–78. http://dx.doi.org/10.1084/jem.191.3.573.

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Chemokines are a family of small proteins that interact with seven-transmembrane domain receptors and modulate the migration of immune cells into sites of inflammation and infection. The murine gammaherpesvirus 68 M3 gene encodes a secreted 44-kD protein with no sequence similarity to known chemokine receptors. We show that M3 binds a broad range of chemokines, including CC, CXC, C, and CX3C chemokines, but does not bind human B cell–specific nor mouse neutrophil–specific CXC chemokines. This herpesvirus chemokine binding protein (hvCKBP) blocks the interaction of chemokines with high-affinity

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3

Palacios-Arreola, M. Isabel, Karen E. Nava-Castro, Julieta I. Castro, Eduardo García-Zepeda, Julio C. Carrero, and Jorge Morales-Montor. "The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets." Journal of Immunology Research 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/849720.

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Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine receptors; thus, there is no unique ligand for each receptor and the binding of different chemokines to the same receptor might have disparate effects. Complicating the system further, these effects depend on the cellular milieu. In cancer, although chemokines are associated primarily with the generation of a protumoral microenvironment and organ-di

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4

Palomino, Diana Carolina Torres, and Luciana Cavalheiro Marti. "Chemokines and immunity." Einstein (São Paulo) 13, no. 3 (2015): 469–73. http://dx.doi.org/10.1590/s1679-45082015rb3438.

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Abstract (sommario):

Chemokines are a large family of small cytokines and generally have low molecular weight ranging from 7 to 15kDa. Chemokines and their receptors are able to control the migration and residence of all immune cells. Some chemokines are considered pro-inflammatory, and their release can be induced during an immune response at a site of infection, while others are considered homeostatic and are involved in controlling of cells migration during tissue development or maintenance. The physiologic importance of this family of mediators is resulting from their specificity − members of the chemokine fam

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Dyer, Douglas P., Elisa Migliorini, Catherina L. Salanga, Dhruv Thakar, Tracy M. Handel, and Ralf P. Richter. "Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization." Open Biology 7, no. 1 (2017): 160286. http://dx.doi.org/10.1098/rsob.160286.

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Chemokines control the migration of cells in normal physiological processes and in the context of disease such as inflammation, autoimmunity and cancer. Two major interactions are involved: (i) binding of chemokines to chemokine receptors, which activates the cellular machinery required for movement; and (ii) binding of chemokines to glycosaminoglycans (GAGs), which facilitates the organization of chemokines into haptotactic gradients that direct cell movement. Chemokines can bind and activate their receptors as monomers; however, the ability to oligomerize is critical for the function of many

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6

Horuk, Richard. "Chemokines." Scientific World JOURNAL 7 (2007): 224–32. http://dx.doi.org/10.1100/tsw.2007.6.

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Chemokines are a family of polypeptides that direct the migration of leukocytestoward a site of infection. They play a major role in autoimmune disease and chemokine receptors have recently been found to mediate HIV-1 fusion. In this short review we examine the role of chemokines in host defence and in the pathophysiology of autoimmune diseases. We conclude by discussing various therapeutic approaches that target chemokine receptors and that could be beneficial in disease.

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Colditz, Ian, Martin Schneider, Monika Pruenster, and Antal Rot. "Chemokines at large: In-vivo mechanisms of their transport, presentation and clearance." Thrombosis and Haemostasis 97, no. 05 (2007): 688–93. http://dx.doi.org/10.1160/th07-02-0105.

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SummaryCompelling evidence implicates chemokines in the induction of leukocyte emigration from blood into tissues.This arguably most fundamental effect of chemokines is accomplished by triggering cognate classical G-protein-coupled chemokine receptors on the leukocyte surface. In vitro, these same receptors mediate leukocyte migration; however, the mechanisms of chemokine-induced migration differ between in-vivo and in-vitro settings. Leukocyte egress from blood is greatly influenced by haemodynamic conditions and requires full cooperation of endothelial cells.The behaviour of chemokines in th

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8

Blanchet, Xavier, Christian Weber, and Philipp von Hundelshausen. "Chemokine Heteromers and Their Impact on Cellular Function—A Conceptual Framework." International Journal of Molecular Sciences 24, no. 13 (2023): 10925. http://dx.doi.org/10.3390/ijms241310925.

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Abstract (sommario):

Chemoattractant cytokines or chemokines are proteins involved in numerous biological activities. Their essential role consists of the formation of gradient and (immune) cell recruitment. Chemokine biology and its related signaling system is more complex than simple ligand–receptor interactions. Beside interactions with their cognate and/or atypical chemokine receptors, and glycosaminoglycans (GAGs), chemokines form complexes with themselves as homo-oligomers, heteromers and also with other soluble effector proteins, including the atypical chemokine MIF, carbohydrate-binding proteins (galectins

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WARD, Stephen G., and John WESTWICK. "Chemokines: understanding their role in T-lymphocyte biology." Biochemical Journal 333, no. 3 (1998): 457–70. http://dx.doi.org/10.1042/bj3330457.

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The chemokines are a complex superfamily of small, secreted proteins that were initially characterized through their chemotactic effects on a variety of leucocytes. The superfamily is divided into families based on structural and genetic considerations and have been termed the CXC, CC, C and CX3C families. Chemokines from these families have a key role in the recruitment and function of T lymphocytes. Moreover, T lymphocytes have also been identified as a source of a number of chemokines. T lymphocytes also express most of the known CXC and CC chemokine receptors to an extent that depends on t

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Weber, Michele, Emma Blair, Clare V. Simpson, et al. "The Chemokine Receptor D6 Constitutively Traffics to and from the Cell Surface to Internalize and Degrade Chemokines." Molecular Biology of the Cell 15, no. 5 (2004): 2492–508. http://dx.doi.org/10.1091/mbc.e03-09-0634.

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The D6 heptahelical membrane protein, expressed by lymphatic endothelial cells, is able to bind with high affinity to multiple proinflammatory CC chemokines. However, this binding does not allow D6 to couple to the signaling pathways activated by typical chemokine receptors such as CC-chemokine receptor-5 (CCR5). Here, we show that D6, like CCR5, can rapidly internalize chemokines. However, D6-internalized chemokines are more effectively retained intracellularly because they more readily dissociate from the receptor during vesicle acidification. These chemokines are then degraded while the rec

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Tesi sul tema "Chemokines"

1

Davis, Christopher Nathan. "Mammalian and viral chemokines provide insight into the mechanism of chemokine receptor activation." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0006481.

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Hua, Renyi. "The role of chemokines/chemokine receptors in labour." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9847.

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Human labour is shown to be an inflammatory process, which involves a marked leukocyte infiltrate into myometrium during labour. My study focused on the role of chemokines, key mediators of leukocyte trafficking, in labour. Previous gene array data obtained from human labouring myometrium showed that the mRNA expression of the following chemokines was increased in term labouring myometrium, CCL2, CCL20, CXCL1, CXCL5, CXCL8. I decided to focus on myometrial expression of these chemokines and also to include CCL5, another important chemokine. My data confirmed that the expression of human myomet

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3

Wong, Jeffrey K. W. "Chemokines and chemokine receptors in islet xenograft rejection." Thesis, The University of Sydney, 2006. https://hdl.handle.net/2123/28055.

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This project investigates the role of chemokine and chemokine receptors in a model of CD4 T cell dependent cellular xenograft rejection, specifically the transplantation of fetal pig pancreas tissue to the renal subcapsular space of mice. Chemokines and chemokine receptor gene expression was assessed by cDNA arrays, and confirmed by multi-probe ribonuclease protection assay. Immunostaining for a selected chemokine, RANTES was performed to demonstrate upregulation at the protein level. These methods were applied to several different models to dissect the role Chemokines and their re

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Mowafi, Frida. "Chemokines and chemokine receptors during viral infections in man /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-420-4/.

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Teleshova, Natalia. "Studies on co-stimulatory molecules, chemokines and chemokine receptors in neuroimmunological diseases /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4781-3/.

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Wang, Jixin. "Bioinformatic analysis of chicken chemokines, chemokine receptors, and Toll-like receptor 21." Texas A&M University, 2006. http://hdl.handle.net/1969.1/4212.

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Chemokines triggered by Toll-like receptors (TLRs) are small chemoattractant proteins, which mainly regulate leukocyte trafficking in inflammatory reactions via interaction with G protein-coupled receptors. Forty-two chemokines and 19 cognate receptors have been found in the human genome. Prior to this study, only 11 chicken chemokines and 7 receptors had been reported. The objectives of this study were to identify systematically chicken chemokines and their cognate receptor genes in the chicken genome and to annotate these genes and ligand-receptor binding by a comparative genomics approach.

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Maru, Seema V. "The role of chemokines and chemokine receptors in astrocytes and astrocytoma biology." Thesis, Open University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427496.

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Brozyna, Sheree. "The role of chemokines and chemokine receptors in chronic obstructive pulmonary disease (COPD) /." Title page and abstract only, 2005. http://web4.library.adelaide.edu.au/theses/09SB/09sbb8859.pdf.

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Simmons, Graham. "Human immunodeficiency syndrome virus type 1 cell tropism and inhibition by chemokines and chemokine analogues." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368041.

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Juremalm, Mikael. "The Role of Chemokines in Mast Cell Migration." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3273.

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<p>Mast cells are very potent multifunctional effector cells of the immune system normally distributed throughout connective tissues. An accumulation of mast cells has been described in several pathological conditions such as allergic- and autoimmune inflammations and in certain tumours. This necessitates two different processes: 1) Recruitment of mast cell progenitors from peripheral blood; 2) Accretion of mature mast cells at sites of inflammation and tumour areas. Both processes are depending on the local production of chemotactic factors. The aim of this study was to investigate the role o

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Più fonti

Libri sul tema "Chemokines"

1

M, Schwiebert Lisa, ed. Chemokines, chemokine receptors, and disease. Elsevier Academic, 2005.

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2

Cardona, Astrid E., and Eroboghene E. Ubogu, eds. Chemokines. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-426-5.

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Tschammer, Nuska, ed. Chemokines. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14060-5.

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4

service), ScienceDirect (Online, ed. Chemokines. Academic, 2009.

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E, Kownatzki, and Norgauer J, eds. Chemokines and skin. Birkhauser Verlag, 1998.

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Ubogu, Eroboghene E., and Astrid E. Cardona. Chemokines: Methods and protocols. Humana Press, 2013.

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7

Lindley, I. J. D., J. Westwick, and S. Kunkel, eds. The Chemokines. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2952-1.

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8

Rollins, Barrett J., ed. Chemokines and Cancer. Humana Press, 1999. http://dx.doi.org/10.1007/978-1-59259-701-7.

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Hébert, Caroline A., ed. Chemokines in Disease. Humana Press, 1999. http://dx.doi.org/10.1007/978-1-59259-706-2.

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10

Kownatzki, Eckhard, and Johannes Norgauer, eds. Chemokines and Skin. Birkhäuser Basel, 1998. http://dx.doi.org/10.1007/978-3-0348-8843-1.

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Capitoli di libri sul tema "Chemokines"

1

Szekanecz, Zoltán, and Alisa E. Koch. "Chemokines and chemokine receptors." In New Therapeutic Targets in Rheumatoid Arthritis. Birkhäuser Basel, 2009. http://dx.doi.org/10.1007/978-3-7643-8238-4_8.

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Mantovani, A., P. Allavena, C. Garlanda, et al. "Chemokines and Chemokine Receptors." In From Basic Immunology to Immune-Mediated Demyelination. Springer Milan, 1999. http://dx.doi.org/10.1007/978-88-470-2143-3_7.

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Luster, Andrew D., and James MacLean. "Chemokines and Chemokine Receptors." In Physiology of Inflammation. Springer New York, 2001. http://dx.doi.org/10.1007/978-1-4614-7512-5_6.

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Lira, Sergio A., Paul J. Zavodny, and Daniel Lundell. "Chemokines." In New Cytokines as Potential Drugs. Birkhäuser Basel, 2000. http://dx.doi.org/10.1007/978-3-0348-8456-3_8.

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Barnette, M. S., and R. Schleimer. "Chemokines." In Therapeutic Strategies for Modulating the Inflammatory Diseases. Birkhäuser Basel, 1998. http://dx.doi.org/10.1007/978-3-0348-8857-8_17.

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Teran, Luis M., and Juan R. Velazquez. "Chemokines." In Inflammation and Allergy Drug Design. Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781444346688.ch20.

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Fang, Lei, and Sam T. Hwang. "Chemokines." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_1066-4.

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Eugenin, Eliseo A., and Joan W. Berman. "Chemokines." In Encyclopedia of Medical Immunology. Springer New York, 2014. http://dx.doi.org/10.1007/978-0-387-84828-0_34.

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Fernandez-Botran, Rafael. "Chemokines." In Encyclopedia of Immunotoxicology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-54596-2_248.

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Kalmar, Jayne M., Brigid M. Lynch, Christine M. Friedenreich, et al. "Chemokines." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2221.

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Atti di convegni sul tema "Chemokines"

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Costa, Leonardo, Jürgen Haas, Henriette Rudolph, et al. "The Choroid Plexus Is Permissive for a Preactivated Antigen-Experienced Memory B Cell Subset in Multiple Sclerosis." In Building Bridges in Medical Science 2021. Cambridge Medicine Journal, 2021. http://dx.doi.org/10.7244/cmj.2021.03.001.2.

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Background: The role of B cells in multiple sclerosis (MS) is increasingly recognized. B cells undergo compartmentalized redistribution in blood and cerebrospinal fluid (CSF) during active MS, whereby memory B cells accumulate in the CSF. While B-cell trafficking across the blood– brain barrier has been intensely investigated, cellular diapedesis through the blood–CSF barrier (BCSFB) is incompletely understood. Objectives: To investigate how B cells interact with the choroid plexus to transmigrate into the CSF, we isolated circulating B cells from healthy donors (HC) and MS patients, utilized

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Dahmardeh, Mahyar, Houman Mirzaalian Dastjerdi, Hisham Mazal, Harald Köstler, and Vahid Sandoghdar. "Breaking new ground in protein detection: Self-supervised machine learning and iSCAT enable label-free detection of single proteins below 10 kDa." In Bio-Optics: Design and Application. Optica Publishing Group, 2023. http://dx.doi.org/10.1364/boda.2023.jw2a.3.

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Interferometric scattering (iSCAT) microscopy detects single nanoparticles in a label-free fashion. Utilizing self-supervised machine learning pushes the detection sensitivity of iSCAT to very small proteins and disease markers such as chemokines and cytokines.

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Strieter, Robert. "Abstract ED03-03: CXC chemokines in cancer." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-ed03-03.

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Schneider, Dina, Deepti R. Nagarkar, Emily R. Bowman, et al. "CC Chemokines And RV-Induced Asthma Exacerbations." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4226.

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"Impact of Heparan Sulphate Binding Domain of Chemokine CCL21 to Migration of Breast Cancer Cells." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0132.

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Lymph node metastasis constitutes a key event in breast cancer progression. Chemokines are small proteins, which can promote metastatic spread by inducing cancer cell migration and invasion. Chemokine function is dependant upon their binding to both cell surface heparan sulphate (HS) molecules and to their specific receptor. Our group has demonstrated a significant increase in chemokine receptor CCR7 expression in cancerous breast epithelia compared to healthy controls. This study is designed to test the hypothesis that a non-HS binding forms of chemokine CCL21 can disrupt the normal response

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Drösslerová, Marie, Martina Šterclová, Martina Vašáková, et al. "Role of chemokines, their gene polymorphisms in resectable NSCLC." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.4094.

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Jung, Yun Jung, Wou Young Chung, Keu Sung Lee, Seung Soo Sheen, Joo Hun Park, and Kwang Joo Park. "Significance of interferon gamma-inducible chemokines in pleural effusions." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa4521.

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Mahgoub, Yasmine, Rida Arif, and Susu Zughaier. "Pyocyanin pigment from Pseudomonas aeruginosa modulates innate immune defenses in macrophages." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0137.

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Background: Pseudomonas aeruginosa is a well-known opportunistic pathogen. The gram-negative bacillus, commonly associated with hospital-acquired infections, utilizes the host’s impaired immune responses to establish infection. Of its many virulence factors, pyocyanin is essential for P. aeruginosa to establish its full infectivity. Macrophages act as sentinels of the innate immune system, as well as play other roles in homeostasis, tissue remodeling, and bridging between the innate and adaptive immune systems. Aim: This study aimed to investigate the effects of pyocyanin on macrophage innate

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Zhen, LI, Huiqin Hao, Ze Wang, Wenjing Lu, and Yang Liu. "AB0121 EXPRESSION OF CHEMOKINES AND CHEMOKINE RECEPTORS IN DIFFERENT TISSUES AND THEIR LOCALIZATION IN THE JOINTS OF RATS WITH RHEUMATOID ARTHRITIS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.5189.

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Korchynskyi, Olexandr. "SAT0053 GLYCOSYLATION IN MAMMALS PROTECTS CITRULLINATED CHEMOKINES FROM PARTIAL DEGRADATION." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.8072.

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Rapporti di organizzazioni sul tema "Chemokines"

1

Zou, Chenghui, Weng Zhang, Mao Li, Dan He, Yujie Han, and Mao Lu. A meta-analysis of association between CCL5、CCL11、CCL17 polymorphisms and AD. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.11.0148.

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Review question / Objective: At present, many studies on the association between CCL5、CCL11、CCL17 polymorphisms and atopic dermatitis（AD）are inconsistent. We conducted this meta-analysis of Case control trial to evaluate the association between CCL5、CCL11、CCL17 polymorphisms and atopic dermatitis（AD). Condition being studied: Since the discovery of cytokines, and in particular the role of chemokines in the progression of AD, many clinical studies have been carried out around the world to explore the association of AD with chemokine polymorphism. However, the quality, type and conclusions of st

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2

Fox, David A. Citrullinated Chemokines in Rheumatoid Arthritis. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada611994.

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Reshef, Ran. Chemokine Receptor Signatures in Allogeneic Stem Cell Transplantation. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada610688.

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McCarthy, James B. Chemokine Receptors and Integrin Function in Prostate Cancer. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada412790.

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McCarthy, James B. Chemokine Receptors and Integrin Function in Prostate Cancer. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada391087.

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Shurin, Michael R. Epigenetic Regulation of Chemokine Expression in Prostate Cancer. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada460756.

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Reshef, Ran. Chemokine Receptor Signatures in Allogeneic Stem Cell Transplantation. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada620593.

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Symons, Marc H. Role of Rac GTPases in Chemokine-Stimulated Breast Carcinoma. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada457469.

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Symons, Marc. Role of Rac GTPases in Chemokine-Stimulated Breast Carcinoma Metastasis. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada502287.

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Symons, Marc. Role of Rac GTPasas in Chemokine-Stimulated Breast Carcinoma Metastasis. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada473355.

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