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Letteratura scientifica selezionata sul tema "Circulating Tumour Cells; Exosomes"

Autore: Grafiati

Pubblicato: 7 giugno 2025

Ultima modifica: 2 agosto 2025

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Articoli di riviste sul tema "Circulating Tumour Cells; Exosomes"

Theodoraki, M. N., S. Laban, E. K. Jackson, et al. "Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients." British Journal of Cancer 125, no. 12 (2021): 1677–86. http://dx.doi.org/10.1038/s41416-021-01567-8.

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Abstract Background Head and neck cancers (HNSCC) are highly immunosuppressive. Plasma-derived exosomes of HNSCC patients carry immunomodulatory molecules, and their cargo correlates with clinical parameters. Here, we evaluated the exosomal molecular profile for early detection of treatment failure in locally advanced HNSCC patients treated with conventional therapy. Methods Plasma from 17 HNSCC patients was collected before, during, and after treatment by surgery with adjuvant (chemo)radiation and at recurrence. Exosomes were isolated by size-exclusion chromatography. Total exosomal protein (

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Soda, Narshone, Bernd H. A. Rehm, Prashant Sonar, Nam-Trung Nguyen, and Muhammad J. A. Shiddiky. "Advanced liquid biopsy technologies for circulating biomarker detection." Journal of Materials Chemistry B 7, no. 43 (2019): 6670–704. http://dx.doi.org/10.1039/c9tb01490j.

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In this review, we have summarised the biogenesis, biological significance, isolation and detection technologies of four widely known circulating biomarkers namely circulating tumour cells, circulating tumor specific DNA, microRNA, and exosomes.

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Mehrabi, Ayshin. "Deciphering the Role of AMPK in Regulating Integrin Profile of Tumor-Derived Exosomes as a Potential Antimetastatic Strategy." Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal 8, no. 7 (2024): 1–6. http://dx.doi.org/10.26685/urncst.560.

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Introduction: Cancer cell adapt their metabolic activity to survive in stressful environments with limited nutrients and oxygen. To sense and respond to nutrient cues, cells rely on a “fuel gauge” protein known as AMP-activated protein kinase (AMPK). While previous work has largely focused on AMPK’s role in cell metabolism, its role in metastasis is poorly defined. Interestingly, AMPK also regulates the membrane trafficking of integrins – key proteins in cell adhesion and migration. Recent studies have also shown that circulating integrins in exosomes are predictive of metastasis. Therefore, u

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Nardin, Charlee, Marine Cordonnier, Gaetan Chanteloup, et al. "Circulating PD-L1-exosomes to monitor tumor response in melanoma patients." Journal of Clinical Oncology 37, no. 15_suppl (2019): 9517. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.9517.

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9517 Background: In the era of effective molecular targeted treatments and immunotherapies, there is an urgent need to implement the use of circulating biomarkers in the clinic to facilitate personalized therapy and predict treatment response. We conducted a retrospective study to demonstrate the involvement of circulating PD-L1 exosomes in melanoma patients. Methods: One hundred melanoma patients were included. Exosomes were isolated by ultracentrifugation and evaluated by nanoparticle tracking analysis using a NS300 Instrument (Nanosight, Amesbury, UK). Isolated exosomes were tested for the

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Buscail, Etienne, Charlotte Maulat, Fabrice Muscari, et al. "Liquid Biopsy Approach for Pancreatic Ductal Adenocarcinoma." Cancers 11, no. 6 (2019): 852. http://dx.doi.org/10.3390/cancers11060852.

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Pancreatic cancer is a public health problem because of its increasing incidence, the absence of early diagnostic tools, and its aggressiveness. Despite recent progress in chemotherapy, the 5-year survival rate remains below 5%. Liquid biopsies are of particular interest from a clinical point of view because they are non-invasive biomarkers released by primary tumours and metastases, remotely reflecting disease burden. Pilot studies have been conducted in pancreatic cancer patients evaluating the detection of circulating tumour cells, cell-free circulating tumour DNA, exosomes, and tumour-educ

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Yang, Sujin, Tian-cheng Cheng, Jia-hao Wu, and Wei-xian Chen. "Abstract PO1-23-08: Exosome-based delivery of microRNAs confers adriamycin-resistance to sensitive cells through modulating the immune and metabolism-related gene PTEN in HER2-negative breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO1–23–08—PO1–23–08. http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-23-08.

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Abstract Background: Anthracycline-based chemotherapy is widely used to treat breast cancer. However, acquired drug resistance remains a challenge to successful treatment. Recently, increasing evidence has shown that changes in the tumour immune microenvironment (TIME), in addition to increasing drug resistance of tumour cells, consistently contribute to the development of chemoresistance. Methods: TIME scores and tumor-infiltrating immune cells (TICs) scores were used to investigate the prognosis, clinicopathological characteristics and gene transcriptome profiling of HER2-negative breast can

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R, Dr Kalyani. "Liquid Biopsy : An emerging concept for diagnosis and management of cancer." JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES 09, no. 4 (2019): 91–96. http://dx.doi.org/10.58739/jcbs/v09i4.4.

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Tumour diagnosis is conventionally done by radiological findings and invasive surgical biopsy. Of late non-invasive technique where blood sample, urine and body fluids are used to extract circulating tumour cells (CTC) and genetic material for cancer diagnosis and treatment which is called as “Liquid Biopsy”.1,2 In this technique the liquid sample is used to isolate CTC, circulating tumour DNA (ctDNA), RNA, Exosomes and proteins which are shed by tumour cells into blood circulation, body fluids or urine in most of the cancers depending on the site of the can-cer. This technique enables non-inv

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Jackson, Hannah K., Franziska Linke, Ian Kerr, and Beth Coyle. "MBRS-27. EXOSOMES CARRY DISTINCT miRNAs THAT DRIVE MEDULLOBLASTOMA PROGRESSION." Neuro-Oncology 22, Supplement_3 (2020): iii403. http://dx.doi.org/10.1093/neuonc/noaa222.542.

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Abstract INTRODUCTION Extracellular vesicles (EVs) represent an ideal source of functional biomarkers due to their role in intercellular communication and their ability to protect cargo, including RNA, from degradation. The most investigated EV’s are exosomes, nanovesicles secreted by all cell types and able to cross the blood-brain-barrier. Here we characterised the RNA of exosomes isolated from medulloblastoma cell lines, with the aim of investigating exosomal RNA cargo as potential functional biomarkers for medulloblastoma. METHODS Exosomes derived from a panel of matched (original tumour a

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Whiteside, Theresa L. "Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)." Biochemical Society Transactions 41, no. 1 (2013): 245–51. http://dx.doi.org/10.1042/bst20120265.

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Body fluids of cancer patients contain TEXs (tumour-derived exosomes). Tumours release large quantities of TEXs, and the protein content of exosome or MV (microvesicle) fractions isolated from patients’ sera is high. TEXs down-regulate functions of immune cells, thus promoting tumour progression. We isolated TEXs from tumour cell supernatants and sera of patients with solid tumours or AML (acute myelogenous leukaemia). The molecular profile of TEXs was distinct from that of circulating exosomes derived from normal cells. TEXs were co-incubated with activated T-cells, conventional CD4+CD25neg T

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Manier, Salomon, Erica N. Boswell, Siobhan Glavey, et al. "Mirna Expression Profiling and Proteomic Analysis Of Circulating Exosomes From Multiple Myeloma Patients." Blood 122, no. 21 (2013): 3086. http://dx.doi.org/10.1182/blood.v122.21.3086.3086.

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Abstract Introduction Exosomes are small vesicles (50-100 nm) of endocytic origin, which are released in the extra-cellular milieu by several cell types. It is known that cell-to-cell communication is partially mediated by exosomes. Exosomes play a role in tumor progression where they have been shown to carry and transfer microRNAs (miRNAs) and proteins to the recipient cells. In this study, we sought to characterize circulating exosomes in terms of their ability to modulate the microenvironment, leading to Multiple Myeloma (MM) progression. Method Exosomes were collected from peripheral blood

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Tesi sul tema "Circulating Tumour Cells; Exosomes"

MAZZITELLI, CARLOTTA. "CIrculating TUmor CELls (CTCs), circulating tumor DNA (ctDNA) and exosomes (Ex) in breast cancer patients: a prospective study." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1044956.

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Background The translational study CITUCEL aims to correlate the presence of CTCs and ctDNA at different time points with the clinical outcome of BC patients in neo-adjuvant, adjuvant or advanced setting and to compare the mutational profiles of the primary tumor, CTCs and ctDNA in the different settings. Methods CTCs have been characterized and isolated single or in pool with the DEPArray system, after immunologic negative enrichment with antibodies coupled to magnetic beads against common leukocytes and red blood cells antigens, followed by cells labelling with specific antibody for ep

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Buscail, Etienne. "Intérêt diagnostique de la biopsie liquide dans la prise en charge de l'adénocarcinome canalaire du pancréas à un stade précoce." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0081.

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Introduction:Un des problèmes du cancer du Pancréas (CP) est le temps de latence entre la suspicion du CP et la mise en place des traitements. Les méthodes de biopsie liquide pourraient accélérer la mise en évidence d’éléments tumoraux et le diagnostic.Objectif :L’objectif principal de l’étude était de comparer la performance diagnostique de plusieurs techniques de biopsie liquide chez des patients atteint d’un CP résécable d’emblé. L’objectif secondaire était la corrélation avec le taux de récidive post-opératoire.Méthodes:Tout d'abord, nous avons testé 2 méthodes d'enrichissement CTC pour es

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Bollu, Bapesh Krishna. "Circulating Tumour Cells in Osteosarcoma." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29874.

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Introduction There is now a growing body of work being conducted in the field of liquid biopsies. A liquid biopsy is a technique to look for biomarkers, arising from cancer, within the blood stream which are accessed in a non-invasive manner. These may include circulating tumour cells (CTCs), circulating tumour DNA, circulating RNA or exosomes. Osteosarcoma is the most common bony malignancy of the paediatric population. Metastatic disease has a poor prognosis with a 20-30% survival. The number of tumour cells present at distant sites when identified by traditional radiological and clini

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Khan, M. S. "Circulating tumour cells and biomarkers in neuroendocrine tumours." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1380186/.

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Neuroendocrine tumours(NETs) are heterogeneous with respect to biological behavior. Consequently, prognosis is variable and biomarkers predicting survival or tumour progression are required to inform clinical management. The best available biomarker, histological grade, is assigned using Ki-67 or mitotic count. Agreement between these two indices is implied but analysis of 131 pancreatic and 136 midgut NETs suggested discordances of 44% and 38% respectively. Ki-67 was the superior prognostic marker, making the additional value of mitotic count questionable. Detection of Circulating Tumour Cell

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Kulasinghe, Arutha Jeevana. "Circulating tumour cells in head and neck cancers." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/110534/1/Arutha%20Jeevana_Kulasinghe_Thesis.pdf.

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Metastasis in head and neck cancer patients is responsible for over 50% of deaths. There are currently no tools to identify patients at risk of developing metastasis. Circulating tumour cells (CTC) represent a transient cancer cell population in the blood. In this study, the researcher has developed CTC isolation methodologies and used novel culture formulations to expand patient derived CTCs for therapy testing. Furthermore, the researcher identified biomarkers present on CTCs which could select patients for immunotherapies, a current unmet need. This work sets the foundation for a personaliz

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Nageswaran, Haritharan. "Capture of colorectal circulating tumour cells for mutational analysis." Thesis, University of Surrey, 2016. http://epubs.surrey.ac.uk/810722/.

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Colorectal cancer accounts for 13% of all cancers in the UK. Surgical resection offers the best prospects of a cure but 45% of these patients will still develop metastases with haematogenous spread suspected to be the main method of dissemination to distant sites. Circulating tumour cells (CTCs) are intermediaries in this process and whilst their exact role remains unclear, their presence has proven to be an independent prognostic factor in breast, prostate and colorectal cancer. The capture and isolation of intact CTCs for mutational analysis could not only shed light on the process of metast

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Kapeleris, Joanna C. "Circulating tumour cells in non-small cell lung cancer." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/228607/1/Joanna_Kapeleris_Thesis.pdf.

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Circulating tumour cells (CTCs) have the potential to transform the management of patients with non-small cell lung cancer (NSCLC). The applications of CTCs can identify clinically actionable targets to predict treatment response and to better understand metastasis. CTCs isolated using microfluidics can be used as prognostic indicators of NSCLC as well as characterizing for markers of immunotherapy (PD-L1), molecular targets (ALK, EGFR). Short term cultures were successfully expanded in 9/70 NSCLC patients and cultured for up to 3 months. Optimization of this novel CTC culture model provides o

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Acheampong, Emmanuel. "Assessment of circulating tumour cells in lung cancer patients." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2022. https://ro.ecu.edu.au/theses/2554.

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Lung cancer is among the most prevalent forms of cancer and remains the leading cause of cancer-associated deaths globally. Traditionally, lung cancers are classified as either non-small cell lung cancer (NSCLC) (85%) or small cell lung cancer (SCLC) (15%). About 60% of all cases are diagnosed at an advanced stage, at which the 5-year survival is only 4%. Anti-programmed cell death-1 and its ligand 1 (anti-PD-1/PD-L1) therapies have significantly improved the outcomes for lung cancer patients in recent years. However, prognosis and understanding of an individual patient’s lung cancer are often

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Hamid, Faysal-Bin. "Genetic profiling of circulating tumour cells and DNAs in patients with colorectal carcinoma." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/404861.

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Over the decades, it has been considered that blood-based biopsy or liquid biopsy could be an alternative approach of tumour biopsy. To date, blood-based biomarkers such as circulating tumour cell (CTC) and circulating tumour DNA (ctDNA) have been widely studied and found their significance in patients with several carcinomas including colorectal carcinoma (CRC). Biologically, both CTC and cell-free DNA (cfDNA) have been released from the tumour and circulate freely in the blood. Although they are present in trivial quantity due to minute scale of discharge and rapid clearance from the blood,

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Payne, Rachel. "The clinical and prognostic use of circulating tumour cells in breast cancer." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6957.

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Adjuvant therapies such as endocrine or cytotoxic chemotherapy have been demonstrated to improve overall survival in early breast cancer patients. A blood test to monitor patients at risk of relapse is needed to identify those patients who would benefit from these treatments and those for whom it is not necessary. This is in favour of detecting disseminated tumour cells (DTCs) from painful bone marrow aspirates, currently the gold‐standard method for detecting minimal residual disease (MRD). The use of circulating tumour cells (CTCs) enriched from the blood was investigated for this purpose al

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Libri sul tema "Circulating Tumour Cells; Exosomes"

Oikonomopoulou, Aikaterini. A pilot study to evaluate KLK6 as a biomarker for the detection of circulating tumour cells in ovarian cancer patients. 2004.

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Capitoli di libri sul tema "Circulating Tumour Cells; Exosomes"

Kugeratski, Fernanda G., and Raghu Kalluri. "Exploiting Exosomes for Cancer Diagnosis and Treatment." In Circulating Tumor Cells. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-22903-9_3.

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Georgiadis, Konstantinos L., Kathryn Simpson, Mahmood Ayub, et al. "Circulating Tumour Cells." In Pancreatic Cancer. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6631-8_62-1.

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Taylor, Douglas D., and Gercel-Taylor Cicek. "Circulating Cell-derived Vesicles Mediate Tumor Progression." In Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3697-3_6.

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Radfar, Payar, Hamidreza Aboulkheyr Es, Arutha Kulasinghe, Jean Paul Thiery, and Majid Ebrahimi Warkiani. "Circulating Tumour Cell Isolation and Molecular Profiling; Potential Therapeutic Intervention." In Circulating Tumor Cells. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-22903-9_14.

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Kolinsky, Michael Paul, Nikolas Stoecklein, Maryou Lambros, et al. "Genetic Analysis of Circulating Tumour Cells." In Tumor Liquid Biopsies. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-26439-0_3.

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Chemi, Francesca, Sumitra Mohan, and Ged Brady. "Circulating Tumour Cells in Lung Cancer." In Tumor Liquid Biopsies. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-26439-0_6.

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Van Pham, Phuc. "Breast Circulating Tumour Cells and Breast Cancer Stem Cells." In SpringerBriefs in Stem Cells. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22020-8_7.

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Pondé, Noam Falbel, and Michail Ignatiadis. "Circulating Tumour Cells in Primary Disease: The Seed for Metastasis." In Liquid Biopsies in Solid Tumors. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-50956-3_2.

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Friel, Anne M., John Crown, and Lorraine O’Driscoll. "Analysis of Gene Expression as Relevant to Cancer Cells and Circulating Tumour Cells." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-289-2_5.

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Teoh, Anthony Y. B. "EUS-Guided Portal Vein Aspiration for Circulating Tumour Cells in Colorectal Cancer." In Atlas of Interventional EUS. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-9340-3_53.

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Atti di convegni sul tema "Circulating Tumour Cells; Exosomes"

Ma, Yuchen, Changjiang Liu, Xue Ding, Jin Wang, and Toshihiko Kiwa. "Kinetics analysis of anti-CD9 antibody and H1299 EV using terahertz chemical microscope." In JSAP-Optica Joint Symposia. Optica Publishing Group, 2024. https://doi.org/10.1364/jsapo.2024.18p_b2_15.

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In recent years, hospitals have used PET-CT scans and pathology to detect lung cancer, but PET-CT scans involve the use of radioactive tracers as well as X-rays from the CT scan, frequent scans can increase long-term health risks, and pathology requires advanced technology. Recent studies have shown that exosomes released from cells can provide the information needed to detect and diagnose cancer. Exosomes play an important role in tumourigenesis, cancer invasion, angiogenesis, tumour microenvironment formation and cancer metastasis. Currently, exosome detection methods include SPR and ELISA,

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Strati, Areti D., Martha Zavridou, Evangelos Bournakis, Sophia Mastoraki, and Evi S. Lianidou. "Abstract 2290: Expression pattern of androgen receptor (AR), splice variant 7 (AR-V7) and splice variant 567 (AR-567) in circulating tumor cells and paired plasma-derived exosomes in metastatic castration resistant prostate cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2290.

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Sierra-Agudelo, Jessica N., Lluís Figueras, Miguel Mir, Roberto Paoli, Romen Rodríguez-Trujillo, and Josep Samitier. "Microfluidic Techniques for Circulating Tumour Cells Separation." In The 5th World Congress on New Technologies. Avestia Publishing, 2019. http://dx.doi.org/10.11159/icbb19.108.

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Mason, Alex, Olga Korostynska, Sean Cashman, and Nicholas Bryan. "Novel rapid detection method for circulating tumour cells." In 2017 Eleventh International Conference on Sensing Technology (ICST). IEEE, 2017. http://dx.doi.org/10.1109/icsenst.2017.8304478.

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Xiao, Hui. "Mast cells act as partners in tumour cells metastasis to promote angiogenesis via exosomes." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa3667.

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Ward, Mark P., Bashir M. Mohamed, Laura Kane, et al. "Abstract 764: Influence of platelets and neutrophils on circulating tumour cells." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-764.

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Spring, Kevin J. "Visualization and Clinical Utility of Circulating Tumour Cells (CTCs) for Cancer Management." In 13th Asia Pacific Microscopy Congress 2025. ScienceOpen, 2025. https://doi.org/10.14293/apmc13-2025-0032.

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Kanwar, N., P. Hu, P. Bedard, M. Clemons, D. McCready, and SJ Done. "Abstract PD6-2: Identifying genomic signatures in circulating tumour cells from breast cancer." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-pd6-2.

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Kang, Yoon-Tae, Young Jun Kim, Tae Hee Lee, Jae-Eul Shim, and Young-Ho Cho. "Abstract 1719: Dual-profiling of CTC and exosome from the cultured circulating tumor cells using stimuli-responsive degaradable hydrogels." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1719.

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