Letteratura scientifica selezionata sul tema "Citronellol"
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Articoli di riviste sul tema "Citronellol"
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Chen, Qiu, Li Li Gu e Zheng Hui Zhang. "The Binary Vapor-Liquid Phase Equilibrium of Citronella Oil under High Vacuum". Advanced Materials Research 772 (settembre 2013): 281–86. http://dx.doi.org/10.4028/www.scientific.net/amr.772.281.
Testo completoAbstract (sommario):
Citronellal, citronellol and geraniol are the main components of the natural plant citronella oil, and their vapor-liquid phase equilibrium relationship is the critical data to separate, purify the citronella oil and design rectifying column. Citronella oil is a thermo-sensitive material, so the separation under high vacuum conditions could lower its boiling point and maintain its quality. This paper adopts the precise vapor-liquid phase equilibrium instrument to collect the binary system of citronellal-citronellol, citronellal-geraniol and citronellol-geraniol with the absolute pressure of 1.2kPa. Meanwhile, the corresponding phase equilibrium diagrams are drawn, which provide data support for the distillation of citronella oil.
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Begha, Bruno Piotrovski, Carlos Henrique Antunes e Julianne Milléo. "Coleopterofauna (Insecta: Coleoptera) coletada em armadilhas com óleo essencial de citronela ou seus componentes no município de Ponta Grossa, Paraná, Brasil". EntomoBrasilis 11, n. 2 (31 agosto 2018): 85–94. http://dx.doi.org/10.12741/ebrasilis.v11i2.734.
Testo completoAbstract (sommario):
Resumo. Coleoptera é a ordem mais numerosa e diversificada de Insecta. Possuem diversos tipos de alimentação, sendo que os besouros herbívoros atacam cultivos agrícolas e plantas ornamentais causando prejuízos aos agricultores. Conhecer as espécies que afetam o cultivo local é uma forma de diminuir seu impacto e propor formas de manejo corretas. Os objetivos deste trabalho foram identificar os coleópteros coletados em armadilhas contendo o óleo de citronela ou seus componentes (citronelal, citronelol e geraniol) instaladas em Ponta Grossa, Paraná e, caracterizar a coleopterofauna através de diferentes análises ecológicas. Somente os coleópteros foram identificados e contabilizados. O programa ANAFAU analisou: índices de frequência, abundância, dominância e constância. Pelo PAST avaliou-se a diversidade, equitatividade e similaridade da comunidade atraída pelas armadilhas. Foram coletados 1269 coleópteros, distribuídos em 23 famílias. Diabrotica speciosa (Germar)foi a única espécie superdominante, superabundante, superfrequente e constante ao longo de toda a amostragem, correspondendo a 54,68% das coletas. Citronela 1% (25,22%), citronelol 1% (25,06%) representaram 50,28% das capturas. Citronela 1% teve a maior diversidade e riqueza de espécies e citronelol 0,5% a menor. O citronelal 1% e o citronelol 1% apresentaram maior similaridade entre as espécies capturadas nestas duas armadilhas. É possível inferir que a distribuição dos coleópteros capturados nos compostos ocorreu devido à presença de moléculas do atrativo também estarem presentes em seus feromônios. O elevado número de D. speciosa coletadas confirma o potencial atrativo dos compostos testados que podem vir a auxiliar na redução de pragas agrícolas, diminuindo o uso de agrotóxicos.Coleopterofauna (Insecta: Coleoptera) collected in traps with essential oil of citronella or its components in the city of Ponta Grossa, Paraná, BrazilAbstract. Coleoptera is the most numerous and diverse order of Insecta. They have various feeding behaviors, being that herbivorous beetles attack agricultural crops and ornamental plants, causing losses to farmers. Knowing the species that affect the local culture is a way to reduce its impact and to propose correct ways of handling them. The objectives of this research were to identify Coleoptera collected in traps containing citronella oil or its components (citronellal, citronellol and geraniol) installed in Ponta Grossa, Paraná, and to characterize the coleopterofauna through different ecological analysis. Only beetles were identified and counted. The ANAFAU program analyzed: indices of frequency, abundance, dominance and constancy. For PAST, the diversity, equity and similarity of the community attracted by the traps was evaluated. A total of 1269 beetles were collected, distributed in 23 families. Diabrotica speciosa (Germar) was the only superdominant, superabundant, superfrequent and constant species throughout the whole sampling, corresponding to 54.68% of the captures. Citronella 1% (25.22%) and citronellol 1% (25.06%) represented 50.28% of the catches. Citronella 1% had the highest diversity and species richness and citronellol 0.5% the lowest. Citronellal 1% and citronellol 1% showed greater similarity between the species captured in these two traps. It is possible that the distribution of the Coleoptera captured in the compounds occurred due to the presence of attractive molecules also being present in their pheromones. The high number of D. speciosa collected confirms the attractive potential of the tested compounds that may help to reduce agricultural pests, reducing the use of agrochemicals.
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Milléo, Julianne, Carlos Henrique Antunes, Elis Borges Pettres, Ricardo Antonio Ayub e Paulo Vitor Farago. "Óleo essencial de citronela (Poaceae) e seus componentes para controle do brasileirinho (Coleoptera: Chrysomelidae) em olerícolas". EntomoBrasilis 12, n. 1 (30 aprile 2019): 06–10. http://dx.doi.org/10.12741/ebrasilis.v12i1.782.
Testo completoAbstract (sommario):
Resumo. Este estudo teve como objetivo obter uma formulação atrativa à base de óleo de citronela e seus componentes voláteis para captura de Diabrotica speciosa (Germar). Três experimentos sequenciais foram realizados em culturas de abobrinha ou pepino. Os insetos foram coletados por armadilhas de garrafa PET com três aberturas laterais, contendo um volume de 200 ml de cada formulação, suspensas a 10 cm do nível do solo numa área experimental de 30 m2. No primeiro experimento foram testados óleo de citronela em 1, 2 e 4%. No segundo investigou-se também a ação de citronelal, citronelol e geraniol a 1%. E, o citronelol a 0,5, 1 e 2% foi testado no terceiro experimento. Como resultado observou-se que a formulação contendo citronelol a 0,5% foi estatisticamente superior às demais. Outros insetos foram capturados pelas armadilhas como coleópteros Diabrotica viridula (Fabricius)e Astylus variegatus (Germar), e também exemplares de Diptera, Hemiptera e Hymenoptera. Considerando a alta demanda por alimentos orgânicos e da preocupação com o ambiente e a saúde, a emulsão a base de citronelol em 0,5% cumpre adequadamente o seu objetivo, garantindo uma boa capacidade atrativa para D. speciosa. Esta formulação pode ser usada paralelamente com outros métodos alternativos para reduzir a presença desse inseto nas culturas.Citronella (Poaceae) essential oil and its components for the control of brasileirinho (Coleoptera: Chrysomelidae) in vegetable cropsAbstract. The present study aimed to get an attractive formulation of oil-based citronella and its volatile components to capture Diabrotica speciosa (Germar). Three sequential experiments were performed in zucchini or cucumber crops. The insects were collected in PET bottle traps with three lateral apertures, containing a volume of 200 ml of each formulation, suspended 10 cm above the ground level in an experimental area of 30 m2. In the first experiment citronella essential oil was tested at 1, 2 and 4%. In the second experiment the action of citronellal, citronellol and geraniol at 1% were investigated. Furthermore, citronellol at 0.5, 1 and 2% has been tested in the third experiment. As a result it was observed that the formulation containing 0.5% citronellol was statistically higher than the other tested formulations. Other insects were captured by the traps as the beetles of Diabrotica viridula (Fabricius)and Astylus variegates (Germar), and also copies of Diptera, Hemiptera and Hymenoptera. Considering the high demand for organic food, and concern for the environment and health, the citronellol emulsion at 0.5% adequately fulfilled its goal, ensuring a good attractive capacity for D. speciosa. This formulation can be used simultaneously with other alternative methods to reduce the presence of such insects in crops.
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Eden, Willy Tirza, Dante Alighiri, Kasmadi Imam Supardi e Edy Cahyono. "The Mosquito Repellent Activity of the Active Component of Air Freshener Gel from Java Citronella Oil (Cymbopogon winterianus)". Journal of Parasitology Research 2020 (29 gennaio 2020): 1–5. http://dx.doi.org/10.1155/2020/9053741.
Testo completoAbstract (sommario):
This study examines the active component of Cymbopogon winterianus (Java citronella) oil, as a green mosquito repellent, obtained through a steam distillation method. Java citronella oil, which contains citronellol, citronellal, and geraniol, was isolated by batch vacuum fractional distillation, and their effect was tested against the dengue fever (DF) vector, known as Aedes aegypti. Furthermore, air freshener gels were formulated with Java citronella oil, carrageenan, gum, sodium benzoate, ethylene glycol, polysorbate 20, sodium chloride, and distilled water, at varying concentrations. The results show that formula I has the best controlled release evaporation for citronellal, citronellol, and geraniol, as well as the best storage time of 16.82 days and 12.77 days for geraniol and citronellol, respectively. The most significant specific gravity (0.0136) was recorded in formula V, while gel formula I exhibited the highest level of instability at 35°C, with a syneresis value of 77.11% in t=72 h and pH 5.33. In addition, formula IV at 5°C demonstrated the highest syneresis (75.34%) in t=72 h, with pH 7.04, while a peak viscosity of 100,958 cP was recorded in formula IV. The repellent activity of each active component was measured based on the period of protection conferred against the bites of Aedes aegypti within one hour, and the results showed geraniol and citronellol, with respective activity of 78.00%±4.83 and 77.34%±3.57, as the most effective.
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Widiyarti, Galuh, Firdayani Firdayani, Muhammad Hanafi, Soleh Kosela e Emil Budianto. "Molecular Docking of Citronellol, Geraniol and Ester Derivatives as Pim 1 Kinase Inhibitor of Leukemia Cancer". Jurnal Kimia Valensi 5, n. 2 (30 novembre 2019): 133–42. http://dx.doi.org/10.15408/jkv.v5i2.7195.
Testo completoAbstract (sommario):
The proviral insertion site in Moloney murine leukemia virus-1 (Pim1) kinase is overexpressed in many human cancer diseases. Inhibition of Pim1 kinase has been reported can suppress cell proliferation and induce apoptotic cell death, so that the protein could be chosen as drug target for the treatment of cancer. Citronellol and geraniol mainly contained in citronella oil that’s one of Indonesian natural products have bioactivity as antitumor agents, so that both of the compounds can be used as guiding compound to be developed as chemoprevention and chemotherapeutic agent compounds for cancer especially for leukemia cancer. In this research, sixteen citronellol and geraniol esters as an inhibitor of leukemia cancer designed were docked based on their interaction with leukemia receptor target of Pim1 kinase by using Molegro Virtual Docker (MVD). The result showed that the binding citronellol and geraniol esters to Pim1 kinase are more stable and better affinity than the binding between citronellol and geraniol, indicated by rerank score were lower than rerank score of citronellol/geraniolPim1 kinase. The docking resulted in the four top-ranked compounds, namely, citronellyl caproate, citronellyl caprylate, geranyl caproate and geranyl caprylate with rerank score value from -182.560 to -189.822 KJ/mol. These compounds have hydrogen bonding with amino acid residues of Lys 67 and Asp 186 of an active site of Pim1 kinase. Based on Lipinski’s rule of five, among of the four top-ranked compounds, citronellyl caproate and geranyl caproate were predicted have potency as new chemopreventive and chemotherapeutic agents for leukemia anticancer candidates.
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Ohashi, Yuka, Shuai Huang e Isamu Maeda. "Biosyntheses of geranic acid and citronellic acid from monoterpene alcohols by Saccharomyces cerevisiae". Bioscience, Biotechnology, and Biochemistry 85, n. 6 (13 marzo 2021): 1530–35. http://dx.doi.org/10.1093/bbb/zbab039.
Testo completoAbstract (sommario):
ABSTRACT Geraniol is one of the important aromatic ingredients in alcoholic beverages. Bioconversions of geraniol to other terpenoids and genes involved in the oxidation of geraniol were investigated. Geranic acid and citronellic acid were detected in yeast culture, where geraniol or nerol was added. Addition of citral, a mixture of geranial and neral, resulted in the production of geranic acid and citronellic acid, whereas the addition of citral or citronellal resulted in the production of citronellic acid, suggesting that citronellic acid might be produced through the conversion of citral to citronellal followed by the oxidation of citronellal. Consumption of geraniol and production of geranic acid, citronellic acid, and citronellol were affected in adh1Δ, adh3Δ, adh4Δ, and sfa1Δ yeast strains, which possess single deletion of a gene encoding alcohol dehydrogenase. This is the first report of the bioconversion of monoterpene alcohols, geraniol and nerol, to geranic acid and citronellic acid in yeast culture.
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Bhatnagar, Anju. "Composition variation of essential oil of Cymbopogon spp. growing in Garhwal region of Uttarakhand, India". Journal of Applied and Natural Science 10, n. 1 (1 marzo 2018): 363–66. http://dx.doi.org/10.31018/jans.v10i1.1631.
Testo completoAbstract (sommario):
The present study was aimed to find out the chemical constituents of essential oils of cymbopogon species,viz. Cymbopogon martinii var motia, Cymbopogon flexuosus Nees., Cymbopogon winterianus Jowitt., growing in Garhwal region of Uttarakhand, India. The essential oils were obtained by hydro-distillationand subjected to detailed Gas Chromatography-Mass Spectroscopy (GC-MS) analysis in order to determine the variation in their volatile constituents. Twenty seven compounds are α-pinene, β-myrcene, Limonene, Cis-b-Ocimene, pCymene ,Terpinolene,6-Methyl hept-5-en-2-one, Citronellal, Linalool, Linalyl acetate, β-Elemene, β-Caryophyllene, Citronellyl acetate, Neral, α– Terpineol, Borneol,Gerainal, γ-Cadinene,Geranyl acetate, Citronellol,Nerol,Geraniol, Caryophyllene oxide,Germacrene—D-4-ol,Elemol, Epi-α-cadinol, δ-Cadinol representing 92.24 to 95.86% of the oil compositions as identified. While comparing the common constituents of three different species of cymbopogon taxa , the remarkable variation in compositions of essential oil was observed and it was in concentration of nearl (0.40;34.9;1.6), gerainal (nil;47.5;0.96) geraniol (82.5;4.5;20.15) , citronellol (T;0.2;12.39) , citronellal (0.1;0.5;36.19) , and linalool (0.8;1.6;0.96) for C.martini, C.flexuosus, C. winterianus respectively
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Ho, Yathsoeung, Nungruthai Suphrom, Krai Daowtak, Pachuen Potup, Yordhathai Thongsri e Kanchana Usuwanthim. "Anticancer Effect of Citrus hystrix DC. Leaf Extract and Its Bioactive Constituents Citronellol and, Citronellal on the Triple Negative Breast Cancer MDA-MB-231 Cell Line". Pharmaceuticals 13, n. 12 (18 dicembre 2020): 476. http://dx.doi.org/10.3390/ph13120476.
Testo completoAbstract (sommario):
Triple negative breast cancer is one of the most aggressive breast cancer type with abilities of early metastasis and chemoresistance. The tropical plant Citrus hystrix DC. has been reported to promote many biological activities including anticancer. However, the effect of C. hystrix against triple negative breast cancer has not yet been identified. This study aimed to evaluate the anticancer properties of C. hystrix leaf extract and its bioactive constituents citronellol and citronellal against the triple negative breast cancer MDA-MB-231 cell line. C. hystrix leaves were powdered and sequentially macerated. The in vitro anticancer effects of C. hystrix leaf extracts, and its bioactive constituents (citronellol and citronellal) were evaluated against MDA-MB-231 cell line using cytotoxic MTT assay, cell proliferation, wound scratch migration, colony formation, cell cycle, apoptosis assay, Hoechst staining, RT-qPCR, and Western blot analysis. Results showed that crude hexane extract, citronellol, and citronellal significantly reduced cell proliferation, colony formation, and cell migration by inducing cell cycle arrest, while also inducing apoptosis in MDA-MB-231 cells through inhibition of anti-apoptotic Bcl-2 expression, leading to activation of the caspase-3-dependent pathway. This study is the first report to demonstrate the effect of C. hystrix, citronellol, and citronellal against triple negative breast cancer MDA-MB-231 cells.
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Jia, Yunpeng, Qizhou Wang, Jingjing Qiao, Binbin Feng, Xueting Zhou, Lijun Jin, Yingting Feng, Duxia Yang, Chenze Lu e Xiangxian Ying. "Cascading Old Yellow Enzyme, Alcohol Dehydrogenase and Glucose Dehydrogenase for Selective Reduction of (E/Z)-Citral to (S)-Citronellol". Catalysts 11, n. 8 (30 luglio 2021): 931. http://dx.doi.org/10.3390/catal11080931.
Testo completoAbstract (sommario):
Citronellol is a kind of unsaturated alcohol with rose-like smell and its (S)-enantiomer serves as an important intermediate for organic synthesis of (-)-cis-rose oxide. Chemical methods are commonly used for the synthesis of citronellol and its (S)-enantiomer, which suffers from severe reaction conditions and poor selectivity. Here, the first one-pot double reduction of (E/Z)-citral to (S)-citronellol was achieved in a multi-enzymatic cascade system: N-ethylmaleimide reductase from Providencia stuartii (NemR-PS) was selected to catalyze the selective reduction of (E/Z)-citral to (S)-citronellal, alcohol dehydrogenase from Yokenella sp. WZY002 (YsADH) performed the further reduction of (S)-citronellal to (S)-citronellol, meanwhile a variant of glucose dehydrogenase from Bacillus megaterium (BmGDHM6), together with glucose, drove efficient NADPH regeneration. The Escherichia coli strain co-expressing NemR-PS, YsADH, and BmGDHM6 was successfully constructed and used as the whole-cell catalyst. Various factors were investigated for achieving high conversion and reducing the accumulation of the intermediate (S)-citronellal and by-products. 0.4 mM NADP+ was essential for maintaining high catalytic activity, while the feeding of the cells expressing BmGDHM6 effectively eliminated the intermediate and by-products and shortened the reaction time. Under optimized conditions, the bio-transformation of 400 mM citral caused nearly complete conversion (>99.5%) to enantio-pure (S)-citronellol within 36 h, demonstrating promise for industrial application.
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Batish, Daizy R., Harminder Pal Singh, Nidhi Setia, Shalinder Kaur e Ravinder K. Kohli. "Chemical Composition and Inhibitory Activity of Essential Oil from Decaying Leaves of Eucalyptus citriodora". Zeitschrift für Naturforschung C 61, n. 1-2 (1 febbraio 2006): 52–56. http://dx.doi.org/10.1515/znc-2006-1-210.
Testo completoAbstract (sommario):
Abstract A study was undertaken to explore the content and composition of volatile oil from decaying leaves of lemon-scented eucalypt (Eucalyptus citriodora Hook.) not analyzed earlier. GC and GC-MS analysis of the oil (yield 0.6%) revealed the monoterpenoid nature with citronellal (52.2%), citronellol (12.3%) and isoisopulegol (11.9%) as the major constituents. Overall, 17 components were identified that accounted for over 94% of the decaying leaf oil. Surprisingly, the decaying leaf oil contained nearly 1.8% of trans-rose oxide, which is generally absent in eucalypt essential oil. Decaying leaf oil and its major 2 components (citronellal and citronellol) inhibited the germination and root elongation of two weeds D Cassia occidentalis (broad-leaved) and Echinochloa crus-galli (grassy weed). Based on the dose-response studies, I50 values were determined for decaying leaf oil and the effect was more on germination only of broad-leaved weed (C. occidentalis), whereas that of citronellal and citronellol were on germination as well as root length of E. crus-galli (grassy weed). Based on I50 values it was observed that citronellal was more phytotoxic and germination inhibiting in nature, whereas citronellol was a more potent root inhibitor, thereby indicating a possible different mode of action. The study concludes that decaying leaf oil hold a good commercial value for exploitation as weed management agent
Tesi sul tema "Citronellol"
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Brito, Renan Guedes de. "Avaliação da atividade antinociceptiva e anti-inflamatória do citronelol em roedores". Universidade Federal de Sergipe, 2013. https://ri.ufs.br/handle/riufs/3854.
Testo completoAbstract (sommario):
Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorThe Citronellol (CT) is an alcoholic monoterpene present in the essential oil of some medicinal plants such as Cymbopogon citratus. Some pharmacological effects such as the antispasmodic and anticonvulsant activities have been described, however it s possible antinociceptive and anti-inflammatory effect is unknown. Thus, the objective of this study was to evaluate the possible antinociceptive and anti-inflammatory action of CT in rodents. Therefore, 362 male Swiss mice (25-35 g) with 2 to 3 months were used. The animals were divided into groups and were treated with CT (25, 50 and 100 mg/kg, i.p.), vehicle (saline solution 0.9% + Tween 80 0.2%, i.p.) or standard drug (i.p.). To evaluate the antinociceptive activity, the animals were submitted to the test of abdomnal constrictions induced by acetic acid (0.85%), the formalin test (1%) and hot plate test. In order to evaluate the effect of CT on orofacial nociception, it was conducted the orofacial test induced by formalin (2%), capsaicin and glutamate. Motor coordination was assessed using the motor coordination test (rota rod) and the spontaneous movement test. The anti-inflammatory activity was evaluated based on the model of carrageenan-induced pleurisy, making up the total leucocyte count. It was also quantified, by using ELISA, TNF-α and nitric oxide generation by macrophages. To determine the central action, the animals were treated with CT, in three doses, or vehicle and, after ninety minutes, were anesthetized, perfused, the brains removed and cut in a cryostat. The brain sections were subjected to immunofluorescence protocol for Fos protein. Results are expressed as mean ± SEM Differences between groups were analyzed by using one way ANOVA test, and followed by Tukey test. Values of p < 0.05 were considered statistically significant. Intraperitoneal administration of CT produced a significant decrease (p < 0.001) of the abdominal constrictions induced by acetic acid. In nociception induced by formalin, the pretreatment with CT caused a significant antinociceptive effect (p <0.01) in both phases of the test. In the hot plate test, the reaction time increased significantly at all doses of CT (p < 0.05 or p < 0.001), while its effect was antagonized by naloxone. In the three orofacial nociception tests, the CT produced a significant decrease (p <0.001) in the face-rubbing time of the orofacial region. No changes were observed in the motor coordination and in the spontaneous movement test. In the evaluation of anti-inflammatory activity, treatment with CT gave rise to a significant decrease (p < 0.01) in total number of leukocytes, decreasing (p < 0.05) the levels of TNF-α and nitric oxide in macrophages (p < 0.05). By immunofluorescence, it was found that CT is able to activate signicantly (p < 0.05) neurons of the olfactory bulb, the piriform cortex, the restrosplenial cortex and the periaqueductal gray. So, it can be concluded that CT has antinociceptive and anti-inflammatory activity and its action is mediated by central and peripheral mechanisms.
O Citronelol (CT) é um monoterpeno alcóolico presente no óleo essencial de algumas plantas medicinais, como o Cymbopogon citratus. Alguns efeitos farmacológicos tais como anti-espasmódico e atividade anticonvulsivante já foram descritos, sendo desconhecido seu possível efeito antinociceptivo e anti-inflamatório. Desta forma, o objetivo do presente estudo foi avaliar a possível ação antinociceptiva e anti-inflamatória do CT em roedores. Para tanto, foram utilizados 362 camundongos Swiss machos (25 a 35 g) com 2 a 3 meses. Os animais foram divididos em grupos e foram tratados com CT (25, 50 e 100 mg/kg; i.p.), veículo (solução salina 0,9% + tween 80 0,2%; i.p.) ou droga padrão (i.p.). Para avaliação da atividade antinociceptiva, os animais foram submetidos ao teste de contorções abdominais induzidas por ácido acético (0,85%), ao teste da formalina (1%) e ao teste da placa quente. Com o intuito de avaliar a ação do CT na nocicepção orofacial, foram realizados os testes de dor orofacial induzida por formalina (2%), capsaicina e glutamato. A coordenação motora dos animais foi avaliada através do teste da coordenação motora (rota rod) e do teste da movimentação espontânea. A atividade anti-inflamatória foi avaliada a partir do modelo de pleurisia induzido por carragenina, realizando-se a contagem de leucócitos totais. Foi quantificado, ainda, através do ensaio imunoenzimático ELISA, o TNF-α e a geração de óxido nítrico por macrófagos. Para determinar a ação central, os animais foram tratados com CT, nas três doses, ou veículo e, noventa minutos após, foram anestesiados, perfundidos, os cérebros extraídos e cortados em criostato. As secções cerebrais foram submetidas ao protocolo de imunofluorescência para proteína Fos. Os resultados foram expressos como média ± erro padrão da média. As diferenças entre os grupos foram analisadas por meio do teste de variância ANOVA, uma via, seguido pelo teste de Tukey. Valores de p < 0,05 foram considerados estatisticamente significantes. A administração intraperitoneal de CT produziu uma redução significativa (p < 0,001) das contorções abdominais. Na nocicepção induzida por formalina, o pré-tratamento com CT causou um efeito antinociceptivo significativo (p <0,01) em ambas as fases do teste. No teste da placa quente, o tempo de reação aumentou significativamente em todas as doses de CT (p < 0,05 ou p < 0,001), tendo seu efeito antagonizado pela naloxona. Nos três testes de nocicepção orofacial, o CT produziu uma redução significativa (p < 0,001) no tempo de fricção da região orofacial. Não foram observadas alterações no teste da coordenação motora e no teste da movimentação espontânea. Na avaliação da atividade anti-inflamatória, o tratamento com CT causou uma diminuição significativa (p < 0,01) no número total de leucócitos, diminuindo os níveis de TNF-α (p < 0,05) e de óxido nítrico em macrófagos (p < 0,05). Através da imunofluorescência, observou-se que o CT é capaz de ativar signicativamente (p < 0,05) neurônios do bulbo olfatório, do córtex piriforme, do córtex retroesplenial e da substância cinzenta periaquedutal. Conclui-se, assim, que o CT apresenta ação antinociceptiva e anti-inflamatória, tendo sua ação mediada por mecanismos centrais e periféricos.
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Filho, Helder Veras Ribeiro. "Cardiorespiratory effects of β-citronellol: involvement of vagal afferent fibers and direct actions on cardiac and smooth muscles". Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14470.
Testo completoAbstract (sommario):
Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgicoβ-Citronelol à um monoterpeno encontrado no Ãleo essencial de diversas plantas aromÃticas utilizadas na medicina popular para tratar hipertensÃo, como a Cymbopogon citratus. O β-citronelol possui propriedades hipotensoras e vasorrelaxantes, porÃm seu mecanismo ainda nÃo està claro. Portanto, o presente estudo foi realizado para abordar essa questÃo em ratos normotensos. Para os experimentos in vivo, ratos Wistar macho foram submetidos a cateterizaÃÃo da artÃria e veia femoral esquerda para registro da pressÃo arterial mÃdia e para administraÃÃo de substÃncias, respectivamente. Eletrodos permitiram o registro da frequÃncia cardÃaca e certos grupos de animais foram traqueostomizados para anÃlise da frequÃncia respiratÃria. Para os experimentos in vitro, os Ãtrios direito e esquerdo, e anÃis de artÃria mesentÃrica foram suspensos em cubas para ÃrgÃos isolados sob condiÃÃes fisiolÃgicas. Em ratos anestesiados com uretana, injeÃÃes intravenosas (i.v.) de β-citronelol (5 e 10 mg/kg) causaram hipotensÃo, bradicardia e apneia em duas fases (fase 1 e fase 2), assim como em animais acordados (5, 10 e 20 mg/kg). A fase 1 dessa trÃade (1 â 2 s de latÃncia), foi abolida pela vagotomia bilateral (BV), pelo tratamento perineural com capsaicina (TP) ou pelo prÃ-tratamento com metilatropina (MA, i.v.), assim como pela injeÃÃo do β-citronelol dentro do ventrÃculo esquerdo, mas manteve-se inalterada pelo prÃ-tratamento i.v. com capsazepina, ondansetrona, suramina ou HC-030031. A fase 2 tardia de bradicardia foi tambÃm reduzida pela BV, TP ou MA, enquanto que a apneia de fase 2 foi abolida apenas pela suramina. Em preparaÃÃes atriais, o β-citronelol induziu efeito cronotrÃpico e inotrÃpico negativos, os quais nÃo parecem estar envolvidos com receptores muscarÃnicos ou adrenÃrgicos, ou alteraÃÃes no influxo de cÃlcio. Em anÃis de artÃria mesentÃrica, com e sem endotÃlio, o β-citronelol relaxou totalmente prÃ-contraÃÃes de fenilefrina com equiparÃvel potÃncia. Esses resultados revelam que a fase 1 de efeitos do β-citronelol origina-se atravÃs de um reflexo vago-vagal resultante da estimulaÃÃo de aferÃncias pulmonares vagais, que parecem nÃo envolver receptores TRPV1, TRPA1, 5-HT3 ou P2X. A fase 2 de hipotensÃo e bradicardia parece resultar de uma aÃÃo de vasodilataÃÃo direta e de um efeito cardÃaco depressor, respectivamente. AlÃm disso, receptores P2X parecem estar envolvidos na mediaÃÃo da resposta de fase 2 de apneia induzida por esse monoterpeno acÃclico.
β-Citronellol is a monoterpene found in the essential oil of various aromatic plants used in folk medicine to treat hypertension such as Cymbopogon citratus. β-Citronellol possesses hypotensive and vasorelaxant properties, but the mechanism of such effects remains unclear. Therefore, the present study was undertaken to address this issue in normotensive rats. For in vivo experiments, male Wistar rats were subjected to catheterization of the left femoral artery and vein for mean arterial pressure monitoring and drug injection, respectively. Electrodes allowed heart rate recordings and some groups of rats were tracheostomized for respiratory rate analysis. For in vitro experiments, right and left atria, and mesenteric artery rings were suspended in organ baths at physiological conditions. In urethane-anesthetized rats, intravenous (i.v.) injections of β-citronellol (5 and 10 mg/kg) caused biphasic (phase 1 and phase 2) hypotension, bradycardia and apnea responses. Biphasic responses was observed also following i.v. injection of β-citronellol (5, 10 and 20 mg/kg) in unanesthetized rats. Phase 1 of this triad (onset time of 1-2 s) was abolished by bilateral vagotomy (BV), perineural treatment with capsaicin (PNT) or pretreatment with methylatropine (MA, i.v.), but remained unaltered by i.v. pretreatment with capsazepine, ondansetron, suramin or HC-030031. Phase 1 responses was absent when β-citronellol was injected into the left ventricle. The delayed phase 2 of bradycardia was also partially reduced by BV, PNT or MA while the apnea component of this phase 2 was only abolished by suramin. In atrial preparations, β-citronellol induced chronotropic and inotropic negative responses, an effect that was related to neither muscarinic and adrenergic receptor activation nor to altered calcium influx. In both endothelium-intact and denuded mesenteric artery rings, β-citronellol fully relaxed phenylephrine-induced contractions in a concentration-dependent manner and with equal potency. These findings reveal that the effects evoked by β-citronellol induced vago-vagal reflex due to stimulation of vagal pulmonary afferents, an effect that seems not involving TRPV1, TRPA1, 5-HT3, or P2X receptors. Phase 2 hypotensive and bradycardiac responses to β-citronellol appears resulting from a direct vasodilatory effect upon vascular smooth muscle and cardiac depressor action, respectively. Furthermore, P2X receptors seem to be involved in the mediation of phase 2 apneic response to this acyclic monoterpene.
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Victoria, Francine Novack. "Novos compostos organosselênio bioativos: estudo da ação antimicrobiana frente à patógenos de importância em alimentos". Universidade Federal de Pelotas, 2010. http://repositorio.ufpel.edu.br/handle/ri/1321.
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Previous issue date: 2010-02-26Java citronella (Cymbopogon nardus (L) Rendle) belongs to the genus Cymbopogon and the essential oil extracted from the plant is constituted mainly by the (+)-R-citronellal (3,7-dimethyl-6-octenal), formed by the secondary metabolism plants. Essential oils and plant extracts have a growing interest to industry and scientific research due to its antimicrobial activity, and as well as compounds organosselênios that are of great interest for scientific research because of its wide spectrum of biological activity. Thus, we performed a study of α-selenation of aldehydes and ketones, including the (+)-( R)-citronellal, as a major component of essential oil of citronella, using PEG/KF/Al2O3, as a recyclable medium. Derivatives of (+)- (R)-citronellal containing organoselenium were assessed for their potential antimicrobial, the antimicrobial activity was determined by the techniques of disk diffusion and minimum inhibitory concentration. The 2-phenylseleno citronellal and 2 phenylseleno citronellol provided yields of 71 and 73% respectively. The antimicrobial activity of 2- phenylseleno citronellal showed the best results, soon the addition of a organoselenium to (+)-R-citronellal increased the antimicrobial activity of (+)-R-citronellal against foodborne pathogenic bacteria Listeria monocytogenes, Staphylococcus aureus and Salmonella Typhimurium.
O capim citronela (Cymbopogon nardus(L) Rendle) pertence ao gênero Cymbopogon, o óleo essencial extraído da planta tem como principal constituinte o (+)-R-citronelal (3,7-dimetil-oct-6-enal), predominantemente formado pelo metabolismo secundário das plantas. Os óleos essenciais e os extratos das plantas possuem um interesse crescente para a indústria e para a pesquisa científica devido a sua atividade antimicrobiana, assim como os compostos organosselênios que são de grande interesse para a pesquisa científica devido ao seu grande espectro de atividade biológica. Desta forma, foi realizado um estudo da α-selenização de aldeídos e cetonas, incluindo o (+)-(R)-citronelal, principal componente do óleo essencial de citronela, utilizando PEG/KF/Al2O3, como meio reciclável. Os derivados do (+)-(R)-citronelal contendo organosselênio foram avaliados em relação aos seus potenciais antimicrobianos, determinados pelas técnicas de difusão do disco e concentração inibitória mínima. Os produtos 2-fenilselenocitronelal e 2-fenilselencitronelol apresentaram rendimentos de 71 e 73%, respectivamente. Nos ensaios de atividade antimicrobiana o produto 2-fenilselenocitronelal apresentou os melhores resultados, inclusive melhores que o (+)-R-citronelal. Logo, a adição de um grupamento de selênio ao composto (+)-R-citronelal aumentou sua atividade antimicrobiana contra Listeria monocytogenes, Staphylococcus aureus e Salmonella Typhimurium.
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Oliveira, Heloisa Mara batista Fernandes de. "Avaliação das atividades antifúngica, antioxidante e citotóxica dos monoterpenos (r)-(+)-citronelal, (s)-(-)-citronelal, 7-hidroxicitronelal". Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/9078.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
Serious infections caused by opportunistic fungal pathogens such as Candida genus, have been increasingly common in immunocompromised patients. The spread of drug-resistant fungi is one of the most serious threats to the successful treatment of fungal diseases, in addition, some drugs are very toxic, hindering adherence to therapy. In this context, the monoterpenes have stood out for having various pharmacological activities such as fungicide and bactericide. It also stands out the antioxidant activity of these compounds by being able to react and inactivate the different reactive species produced during a cellular oxidative stress. Based on this, the antifungal, cytotoxic and antioxidant effect of the monoterpenes (R)-(+)-citronellal (RC), (S)-(-)-citronellal (SC) and 7-hydroxycitronellal (7-OH) were studied. For the analysis of the antimicrobial potential of monoterpenes was used with the in silico analysis software Pass online. For the realization of antifungal studies used the microdilution test with different fungal strains of Candida for evaluation of minimum inhibitory concentration (MIC). In addition, it was determined the Minimum Fungicidal Concentration (MFC) for seeding on plates. In carrying out cytotoxicity studies and antioxidant was used human red blood cells obtained from the transfusion unit of the University Hospital Lauro Wanderley/UFPB. For the antioxidant studies used the techniques with phenylhydrazine and hydrogen peroxide. The study showed that the in silico monoterpenes RC, SC and 7-OH were more likely to be active in percentage, compared to fungal microorganisms. The antifungal activity of experiments revealed that the RC and SC monoterpenes promoted strong antifungal effect with MIC50 of 256 μg/mL for strains of Candida albicans and Candida tropicalis and fungicidal action for presenting CFM50 512 μg/mL. The monoterpene 7-OH showed strong antifungal effect for both strains of Candida albicans and for Candida tropicalis strains with MIC50 of 256 μg/mL and MIC50 512 μg/mL, respectively, and fungicidal action with CFM50 512 μg/mL and 1024 μg/mL. The monoterpenes RC, SC and 7-OH showed no oxidant opposite effect to human erythrocytes. Furthermore, the front monoterpenes had antioxidant effect against phenylhydrazine and hydrogen peroxide. RC analysis of cytotoxicity, SC and 7-OH front of haemolysis erythrocytes showed values below 25% for all blood types tested at a concentration of 256 μg/mL. Given these results, it was possible to infer that the stereoisomerism of RC and SC monoterpenes did not interfere in the tested activities. In conclusion, these results suggest that the RC, SC-OH and 7 show antifungal and antioxidant effect with low cytotoxic effect.
As infecções graves causadas por fungos patogênicos oportunistas, tais como do gênero Candida, têm sido cada vez mais comuns em pacientes imunocomprometidos. A disseminação de fungos resistentes aos medicamentos é uma das mais graves ameaças para o sucesso do tratamento das doenças fúngicas, além disso, algumas drogas são muito tóxicas, dificultando a adesão a terapêutica. Nesse contexto, os monoterpenos têm se destacado por apresentarem diversas atividades farmacológicas tais como: fungicida e bactericida, além da atividade antioxidante, por serem capazes de reagir e inativar as diferentes espécies reativas produzidas durante um estresse oxidativo celular. Com base nisto, foram estudados os efeitos antifúngico, citotóxico e antioxidante dos monoterpenos (R)-(+)-citronelal (RC), (S)-(-)-citronelal (SC) e 7-hidroxicitronelal (7-OH). Para a análise do potencial antimicrobiano dos monoterpenos foi utilizado a análise in silico com o software Pass online. Para a realização dos estudos antifúngicos utilizou-se o teste de microdiluição com diferentes cepas fúngicas do gênero Candida para avaliação da Concentração Inibitória Mínima (CIM). Além disso, determinou-se a Concentração Fungicida Mínima (CFM) por semeio em placas. Na realização dos estudos de atividade citotóxica e antioxidante utilizou-se hemácias humanas obtidas da unidade transfusional do Hospital Universitário Lauro Wanderley/UFPB. Para os estudos antioxidantes utilizou-se as técnicas com fenilhidrazina e peróxido de hidrogênio. O estudo in silico demonstrou que os monoterpenos RC, SC e 7-OH apresentaram uma maior probabilidade de serem ativos, expressa em porcentagem, frente aos microrganismos fúngicos. Os experimentos de atividade antifúngica revelaram que os monoterpenos RC e SC promoveram efeito antifúngico forte com CIM50 de 256 μg/mL para as cepas de Candida albicans e Candida tropicalis, bem como ação fungicida por apresentarem CFM50 512 μg/mL. O monoterpeno 7-OH apresentou forte efeito antifúngico tanto para as cepas de Candida albicans como para as cepas de Candida tropicalis, com CIM50 de 256 μg/mL e CIM50 512 μg/mL, respectivamente, bem como ação fungicida com CFM50 de 512 μg/mL e 1024 μg/mL. Os monoterpenos RC, SC e 7-OH não demonstraram efeito oxidante frente a eritrócitos humanos. Além disso, os monoterpenos apresentaram efeito antioxidante frente a fenilhidrazina e ao peróxido de hidrogênio. A análise da citotoxicidade de RC, SC e 7-OH frente a eritrócitos revelou valores de hemólise abaixo de 25% para todos os tipos sanguíneos testados, na concentração de 256 μg/mL. Diante desses resultados, foi possível inferir que a estereoisomeria dos monoterpenos RC e SC não interferiu nas atividades testadas. Em conclusão, estes resultados sugerem que o RC, SC e 7-OH apresentam efeito antifúngico e antioxidante, com baixo efeito citotóxico.
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Arias, Vecino Pablo. "Role of adsorption in catalysis : applications of NMR relaxometry". Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/248756.
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The work described in this thesis focuses on the effects that adsorption processes on catalytic surfaces pose in controlling key steps that can affect and control reaction pathways. To that, the development of Nuclear Magnetic Resonance (NMR) relaxometry methods and the comparison with traditional catalytic was performed with a series of C5 and C6 unsaturated hydrocarbons on two different alumina supports, γ- and θ-Al2O3. The developed techniques were applied in the study of liquid phase selective hydrogenation of citral on 5% Pt/SiO2. Infrared (IR) spectroscopy, volumetric adsorption isotherms, dynamic isotherms via a Tapered Element Oscillating Microbalance (TEOM), temperature programmed desorption (TPD) as well as 13C T1 NMR and 1H 2D T1-T2 relaxometry methods were employed. Energies of adsorption as a function of coverage were obtained via adsorption isotherms and the particular surface adsorbate interactions were described with IR spectroscopy. For example, 1-pentyne showed the strongest interaction with the alumina (94 kJ mol-1) while 1-pentene presented a weaker interaction (46 kJ mol-1) on θ-Al2O3. Desorption energies obtained from TPD ranged 85 – 130 kJ mol-1, irrespective of the adsorbate. Reactivity of the aluminas was captured with TPD, TEOM and NMR relaxometry. Interaction of adsorbates with hydrocarbon occurred predominantly on weak adsorption sites. 13C NMR T1 relaxometry provided in addition atom-specific adsorbate-adsorbent interaction strengths, showing the molecular geometry of adsorption, and applied in co adsorption measurements. The selective hydrogenation of citral as a model α,β-unsaturated aldehyde and the effect of different solvents on the activity and product distribution was studied at 298 and 373 K. A series of polar protic, polar aprotic and non polar solvents was investigated. Results showed higher initial reaction rates in non polar solvents but higher selectivities towards desired products on polar protic solvents. Solvent used also affected by product formation. The strong variations in reaction rates and selectivities reported were related with adsorbate catalyst interactions, as well as solvent reactant interactions. For example, adsorption isotherms showed that ethanol notably reduced the adsorption capacity of citral as compared with hexane, related with the rate differences observed. ATR-IR measurements indicated solvent citral interactions were solely present in polar protic solvents in line with higher yields of geraniol and nerol. Finally, 13C T1 NMR and 1H 2D T1-T2 correlation experiments determined that the geometry of adsorption of citral, influenced by solvent, affected product selectivity, and that product adsorption affected selectivity and deactivation.
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Paula, Camila Gurgel Dantas de. "Atividade antifúngica in vitro do óleo essencial de cymbopogon nardus L. Rendle (citronela) e do fitoconstituinte citronelal sobre cladosporium carrionii". Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/8637.
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Dematiaceous, demaceous or dark fungi comprise a large, heterogeneous group of fungi that cause a variety of diseases, including feohifomycoses, cromoblastomycoses, mycetoma and allergies. Species of the genus Cladosporium are relevant in developing cromoblatomycoses, and stand out as plant contaminants. The toxicity of conventional antifungal and increased resistance to therapeutic regimens, driving the study of the antifungal activity of new alternatives, including natural sources. Given this context, the aim of this study was to evaluate the In vitro antifungal activity of seven essential oils (Laurus nobilis L., Mentha arvensis, Mentha X piperita L., Mentha spicata, Ocimum basilicum L., Cymbopogon nardus L. Rendle e Origanum vulgare) and the phytoconstituent citronellal on strains of dematiaceous fungi. In this study, the following methods were used: microbiological screening, determining the minimum inhibitory concentration (MIC) and Minimum Fungicidal Concentration (MFC), kinetics of microbial death, inhibition of conidial germination and evaluation of morphological changes. Among the essential oils tested, the C. nardus essential oil demonstrated potent antifungal activity, inhibiting the growth of 83,3% of strains used. The Cymbopogon Nardus L. Rendle (citronella grass) belongs to the family Poaceae, subfamily Panicoideae. The Cymbopogon genus consists of eighty-five species. C. nardus presents constitution of essential oil with two major compounds: the citronellal and geraniol. Citronellal is a monoterpene, predominantly formed by the secondary metabolism of plants. The essential oil of C. nardus had its MIC and MFC established at 64 mg / mL and the citronellal in 32 mg / mL. Both the essential oil of C. nardus as citronellal significantly inhibited the radial mycelial growth of the tested strains, the MIC concentrations, MICx2 and MICx4 after 12 days of exposure. In MIC50 concentrations (64 ug / ml- essential oil and 32μg / ml -citronellal) and MIC90 (128 ug / ml - 512μg essential oil and / ml - citronellal), were able to significantly inhibit the germination of fungal conidia from both strains tested. The determination of the effect of the essential oil of C. nardus and citronellal on the morphogenesis of C. carrionii strains showed that both were capable of inducing morphological changes, as development tortuous hyphae, fine and decreased conidiation in MIC concentrations, MICx2 and MICx4. Thus, it is concluded that the essential oil of C. nardus and its phytoconstituent citronellal showed pronounced antifungal activity against the strains of C. carrionii tested, what drives the study of its In vivo antifungal activity, as well as the search for pharmaceutical formulations to be used for the therapy of certain mycoses, especially those caused by dematiaceous fungi.
Fungos dematiáceos, demáceos ou escuros compõem um grupo grande e heterogêneo de fungos que causam uma variedade de doenças, incluindo feohifomicoses, cromoblastomicoses, micetomas e alergias. Espécies do gênero Cladosporium são relevantes no desenvolvimento de cromoblatomicoses, e se destacam como contaminantes de plantas. A toxicidade dos antifúngicos convencionais e o aumento da resistência aos esquemas terapêuticos utilizados impulsionam o estudo da atividade antifúngica de novas alternativas, incluindo as de fonte natural. Diante desse contexto, o objetivo deste trabalho foi avaliar a atividade antifúngica In vitro de sete óleos essenciais (Laurus nobilis L., Mentha arvensis, Mentha X piperita L., Mentha spicata, Ocimum basilicum L., Cymbopogon nardus L. Rendle e Origanum vulgare) e do fitoconstituinte citronelal sobre cepas de fungos dematiáceos. Neste estudo, os seguintes métodos foram utilizados: triagem microbiológica, determinação da Concentração Inibitória Mínima (CIM) e Concentração Fungicida Mínima (CFM), cinética de morte microbiana, inibição da germinação de conídios e avaliação de alterações morfológicas. Dentre os óleos essenciais testados, o de C. nardus demonstrou uma potente atividade antifúngica, inibindo o crescimento de 83,3% das cepas de fungos demáceos utilizadas. O Cymbopogon nardus L. Rendle (capim-citronela) pertence à família Poaceae, subfamília Panicoideae. O gênero Cymbopogon é constituído de oitenta e cinco espécies. O C. nardus apresenta constituição do óleo essencial com dois compostos majoritários: o citronelal e o geraniol. Citronelal é um monoterpeno, predominantemente formado pelo metabolismo secundário de plantas. O óleo essencial de C. nardus teve sua CIM e CFM estabelecidas em 64 μg/ mL e o citronelal em 32 μg/ mL. Tanto o óleo essencial de C. nardus quanto o citronelal inibiram de forma significativa o crescimento micelial radial das cepas testadas, nas concentrações CIM, CIMx2 e CIMx4, após 12 dias de exposição. Nas concentrações CIM50 (64 μg/ mL- óleo essencial e 32μg/mL -citronelal) e CIM90 (128 μg/mL - óleo essencial e 512μg/mL - citronelal), foram capazes de inibir de forma significativa a germinação dos conídios fúngicos de ambas as cepas testadas. A determinação do efeito do óleo essencial de C. nardus e do citronelal sobre a morfogênese das cepas de C. carrionii demonstrou que ambos foram capazes de induzir alterações morfológicas, como desenvolvimento de hifas tortuosas, finas e diminuição da conidiação, nas concentrações CIM, CIMx2 e CIMx4. Dessa forma, conclui-se que o óleo essencial de C. nardus e o seu fitoconstituinte citronelal mostraram pronunciada atividade antifúngica sobre as cepas de C. carrionii testadas, o que impulsiona o estudo de suas atividades antifúngicas In vivo, bem como a busca por formulações farmacêuticas a serem utilizadas para a terapia de algumas micoses, especialmente aquelas causadas por fungos demáceos.
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Rabelo, Diego de Moura. "Estudo fitoquímico e biológico de guatteria citriodora ducke". Universidade Federal do Amazonas, 2008. http://tede.ufam.edu.br/handle/tede/3332.
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Previous issue date: 2008-01-24Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
The Guatteria citriodora Ducke is an Amazon species known family Annonaceae, popularly as enviara amarela or laranjinha , that occurs in rain forest on land-firm, with distribution on the states of Amazonas and Pará, being found in Guiane and Suriname. The phytochemical study of stem bark of this plant resulted on isolation of three oxoaporphine alkaloids, O-methylmoschatoline, liriodenine and oxoputerine, common in Annonaceae, and previously obtained from species of Guatteria genus. Their identifications were accomplished through spectroscopic analyses (IR, RMN 1H, HSQC and HMBC) and by comparison with the data of the literature. The essential oil extracted from leaves was analyzed by GC/MS and presented as major constituents the monoterpenoids citronnelal (25.5%) and citronnelol (22.4%). The biological evaluation of this oil showed leishmanicidal activity in vitro against Leishmania guianensis (IC50=12.1±1.5 g/mL), and 94.5% of lethality against Artemia salina Leach, in the concentration of 500 g/mL. The species needs more research for the study of its application, for presenting biotechnical potential in its constituents.
A Guatteria citriodora Ducke é uma espécie amazônica da família Annonaceae, conhecida popularmente como envira-amarela ou laranjinha, a qual ocorre em floresta pluvial de terra firme com distribuição nos estados do Amazonas e Pará, bem como nas Guianas, Suriname, Bolívia, Equador, Colômbia, Peru e Venezuela. O estudo fitoquímico da casca do caule dessa planta resultou no isolamento de três alcalóides oxoaporfínicos, O-metilmoshatolina, liriodenina e oxoputerina, essas substâncias foram previamente isoladas e descritas em espécies do gênero Guatteria. A identificação desses compostos foi realizada por meio de técnicas espectroscópicas (IV, RMN 1H, HSQC e HMBC) e por comparação com dados da literatura. O óleo essencial extraído das folhas foi analisado por CG/EM e apresentou como constituintes majoritários os monoterpenóides citronelal (25,5%) e citronelol (22,4%). A avaliação biológica desse óleo apresentou atividade leishmanicida in vitro contra Leishmania guyanensis (CI50=12,1±1,5 g/mL), e 94,5% de letalidade frente à Artemia salina Leach, na concentração de 500 g/mL. A espécie necessita de mais pesquisa para o estudo de suas aplicabilidades, por apresentar potencial biotecnológico em seus constituintes.
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Silva, Jaqueline Maria Ramos da. "Epoxidação quimio-enzimática do citronelol e B-cariofileno". Florianópolis, SC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/96427.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química.Made available in DSpace on 2012-10-26T11:57:09Z (GMT). No. of bitstreams: 1 301775.pdf: 1532162 bytes, checksum: 5f9da1e3cc2b06a41a8e3d8bbdfcb96b (MD5)
In this work, the chemoenzymatic epoxidation of terpenes citronellol and â-caryophyllene is reported. Some experimental conditions, such as the use of different lipases and mycelia, oxidizing agents (H2O2 or UHP), reaction time, acyl donor type, temperature (15-45°C) and the influence of the organic medium, including the use of ionic liquids (ILs) were evaluated. In the epoxidation of citronellol two products were obtained; namely citronellol oxide 43 and/or citronellol epoxide ester 47. Depending on the reaction conditions, the product 43 was obtained in conv. >99%. CAL-B was the most efficient catalyst. The highest conversions were achieved for the epoxide 43 at 20 and 25 °C, with conv. of 80% and 77%. The organic medium was one of the most important parameters in this reaction. Using chloroform or dichloromethane, product 43 was obtained in conversions >99% after 24 h. Using mixtures of organic solvents and ILs, the results were dependent on both the organic solvent and the counter ion type in IL. These parameters were also evaluated when â-caryophyllene was used as the substrate. Using this substrate two products, the mono-epoxide 44 and the di-epoxide 45, were formed. The use of several lipases from different sources was also evaluated, and CAL-B was the most efficient catalyst (conv. >99% in 44). By the use of commercial lipases (Amano PS-C I, F-AP15, Amano PS-C SD, Amano PS, Amano AY 30, Amano PS IM, M Amano 10, 20 Amano AK, Amano PS-C II, A Amano 12, Lipozyme RM IM, Lipozyme IM), the conversions in product 44 were of 16-27%; by using the native lipases LAN and LRO the conversions were 20-23% and using the mycelia UEA_06 and UEA_53, the conversions were 16 and 21%, in 24 h. The best oxidizing agent was H2O2 as compared to UHP, considering that the reaction occurred in a shorter time and only a small amount of the reagent was necessary to obtain 44 or 45 as unique products in high conv. (60 ->99%). Using 2.0 mmol of H2O2, CAL-B could be reused up to 5 times with minimal loss in the conversion degrees to 44 (93-90%). The organic solvents were also selective. By using n-hexane, the preferential formation of 44 was observed with conv. >99% after 8 and 24 h reaction. When ethyl acetate and toluene were used, the conversions were of >99% on 45 after 8 and 24h. It is worth of mentioning that the chemoenzymatic methodology used mild conditions and presented selectivity, as depending on the reaction conditions only one product could be obtained in good conversion degrees.
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Maharaj, Riddhi Anubhav. "The conversion of citronellal over sulphonated polystyrene resin catalysts". Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20486.
Testo completoAbstract (sommario):
Citronellal was converted over sulphonated polystyrene resin catalysts of different acid loading. The catalysts had been prepared sulphonating a commercial polystyrene resin with sulfuric acid. Catalyst activities were screened in the liquid phase and in the gas phase in a temperature range of 50 to 110°C, varying space velocity. Catalyst activities (in terms of rates of citronellal conversion) followed the degree of sulphonation and were similar in both the environments, but apparently governed by external mass transfer control in the liquid phase or limited by the very low partial pressure of citronellal in the gas phase. No effect of the degree of sulphonation on selectivity was observed. [Please note: the fulltext of this thesis has been deferred to 9 June 2018]
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Förster-Fromme, Karin. "Der Citronellolstoffwechsel in Pseudomonaden - Funktionelle Zuordnung beteiligter Gene und deren Produkte". [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-34550.
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Stuttgart, Universiẗat, Diss., 2008.Aus: Appl. Environ. Microbiol. 2006 Jul;72(7):4819-28, FEMS Microbiol. Lett. 2006 Nov;264(2):220-5, Microbiology. 2008 Mar;154(Pt 3):789-96, FEMS Microbiol. Lett. 2005 May 1;246(1):25-31.
Libri sul tema "Citronellol"
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Purnima, Jayasinha, e Industrial Technology Institute (Colombo, Sri Lanka). Information Services Centre., a cura di. Citronella: A literature survey. Colombo: Information Services Centre, Industrial Technology Institute, 1999.
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Jayasinha, Purnima. Citronella ; Cymbopogon Nardus - A Literature Survey. Information Services Centre, Industrial, 1999.
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(Firm), Custom Cartographics. Citrus County, Florida, streetmap: Including Chassahowitzka, Citronelle, Citrus Springs ... Sulphur Spring & Yankeetown. Universal Map, 2001.
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(Firm), Custom Cartographics. Citrus County, Florida, StreetMap: Including Chassahowitzka, Citronelle, Citrus Springs ... Sulphur Spring & Yankeetown. Universal Map, 1999.
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(Firm), Custom Cartographics. Citrus County, Florida, StreetMap: Including Chassahowitzka, Citronelle, Citrus Springs ... Sulphur Spring & Yankeetown. Universal Map, 1998.
Cerca il testo completoCapitoli di libri sul tema "Citronellol"
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Bährle-Rapp, Marina. "Citronellol". In Springer Lexikon Kosmetik und Körperpflege, 114. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_2147.
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Bährle-Rapp, Marina. "Citronellal". In Springer Lexikon Kosmetik und Körperpflege, 114. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_2146.
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Bährle-Rapp, Marina. "Citronellöl". In Springer Lexikon Kosmetik und Körperpflege, 114. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_2148.
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Bährle-Rapp, Marina. "Citronellöl." In Springer Lexikon Kosmetik und Körperpflege, 114. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_2149.
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Bährle-Rapp, Marina. "Citronellyl Acetate". In Springer Lexikon Kosmetik und Körperpflege, 114. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_2150.
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Gooch, Jan W. "Citronella Oil". In Encyclopedic Dictionary of Polymers, 146. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_2414.
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Marulanda, Valentina Aristizábal, Christian David Botero Gutiérrez e Carlos Ariel Cardona Alzate. "Citronella Oil". In Green Pesticides Handbook, 151–84. Boca Raton : Taylor & Francis, CRC Press, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315153131-8.
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Yoshii, Fumiko, Shuichi Hirono e Ikuo Moriguchi. "Odor of (R)-Ethyl Citronellyl Oxalate and Its Conformations". In Olfaction and Taste XI, 280–81. Tokyo: Springer Japan, 1994. http://dx.doi.org/10.1007/978-4-431-68355-1_108.
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de Castro, Heizir F., Diovana A. S. Napoleão e Pedro C. Oliveira. "Production of Citronellyl Acetate in a Fed-Batch System Using Immobilized Lipase Scientific Note". In Biotechnology for Fuels and Chemicals, 667–75. Totowa, NJ: Humana Press, 1998. http://dx.doi.org/10.1007/978-1-4612-1814-2_61.
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Singh, Sonia, Nitin Agrawal e Isha Mishra. "Pharmacology and Phytochemistry of Coriander". In Ethnopharmacological Investigation of Indian Spices, 173–96. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-2524-1.ch014.
Testo completoAbstract (sommario):
Coriander, named as Coriandrum sativum Linn, belongs to the family Umbelliferae and is one of the most popular and well-known spices/condiments and herbal medicines. The essential oils and fatty oils are the two major active chemical constituents present in the plant. The other minor ingredients found to be present are monoterpenes hydrocarbons i-e limonene, γ-terpinene, α-pinene, p-cymene, borneol, citronellol, camphor, geraniol, and geraniol acetate and abd heterocyclic components such as pyrazine, pyridine, thiazole, furan and tetrahudrofuran derivatives, isocoumarins, coriandrin, dihydrocoriandrin, coriandrons A-E, flavonoids. The volatile oil from the leaf contains aromatic acids such as 2-decenoic acid, E-11-tetradecenoic acid, undecyl alcohol, tridecanoic acid, capric acid, undecanoic acid, and more. The current pharmacological research reveals the application of coriander has antibacterial and antifungal activity.
Atti di convegni sul tema "Citronellol"
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Widiyarti, Galuh, Sri Handayani e Muhammad Hanafi. "Synthesis and cytotoxic activity of citronellol esters". In SolarPACES 2017: International Conference on Concentrating Solar Power and Chemical Energy Systems. Author(s), 2018. http://dx.doi.org/10.1063/1.5064295.
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Xie, Wancui, Chao Yin, Xihong Yang, Sheng Lei, Ling Zhang, Wei Zhao e Tiandong Zhang. "Thermal Decomposition Kinetics Analysis of Citronellol- -D-glucopyranoside". In 2016 5th International Conference on Sustainable Energy and Environment Engineering (ICSEEE 2016). Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/icseee-16.2016.147.
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Oelgemo¨ller, Michael, Christian Jung, Ju¨rgen Ortner, Jochen Mattay, Christian Schiel e Elmar Zimmermann. "“Back to the Roofs”: The Solarchemical Production of Fine Chemicals With Sunlight". In ASME 2004 International Solar Energy Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/isec2004-65021.
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Three photochemical reactions were performed successfully under solar irradiation conditions: the photoacylation of quinones with aldehydes and the rose bengal sensitized photooxygenations of citronellol or 1,5-dihydroxynaphthalene. All reactions were easily performed on multigram to kilogram scales using cheap and commercially available starting materials, and yielded important key-intermediates for industrial applications.
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Silva, Jaqueline Maria Ramos da, e Maria da Graça Nascimento. "Influence of temperature on the chemo-enzymatic epoxidation of citronellol". In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0187-3.
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Sudiyarmanto, Luthfiana N. Hidayati, Anis Kristiani, Almira Ghaisani, Dede Sukandar, Indri B. Adilina e Silvester Tursiloadi. "Preparation and characterization of Ni based on natural zeolite catalyst for citronellol conversion to 3,7-Dimethyl-1-Octanol". In PROCEEDINGS OF THE 3RD INTERNATIONAL SYMPOSIUM ON APPLIED CHEMISTRY 2017. Author(s), 2017. http://dx.doi.org/10.1063/1.5011919.
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Silvianti, Risna, Warsito e Chandrawati Cahyani. "Separation Process of Citronellal and Rhodinol from Citronella Oil using Vacuum Fractionations at Pilot Plant Scale". In 2nd International Conference of Essential Oil Indonesia. SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0009957300910095.
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Koperna, George. "SECARB Phase III: Citronelle". In NETL CCUS and Oil & Gas Technologies Integrated Review Meeting. US DOE, 2019. http://dx.doi.org/10.2172/1765830.
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Dittmar, Gary. "SECARB – Plant Barry to Citronelle". In 8th Annual Southeast Regional Carbon Sequestration Partnership Stakeholders’ Briefing. US DOE, 2013. http://dx.doi.org/10.2172/1765142.
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Gerasimchuk, A. L., D. V. Antsiferov, P. A. Bukhtiyarova e D. A. Ivasenko. "OBTAINING A LIPOPHILIC BACTERIAL CONSORTIUM FOR FAT DEPOSITS UTILIZATION". In STATE AND DEVELOPMENT PROSPECTS OF AGRIBUSINESS. DSTU-PRINT, 2020. http://dx.doi.org/10.23947/interagro.2020.1.81-84.
Testo completoAbstract (sommario):
Bacterial strains with lipolytic activities Pseudomonas citronellolis A13, Pseudomonas extremaustralis Б11, Pseudomonas nitroreducens Д14, Pseudomonas sp. B21, Microvirgula curvata B37, Brevibacillus sp. 28Д, Bacillus subtilis spp. B10, B34 were isolated from fat-containing industrial wastewater of food industry and were used for obtaining a lipophilic bacterial consortium that perspective for fat deposits utilization.
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Zulkeflee, S. A., e N. Aziz. "Model Identification for Batch Esterification Process to Produce Citronellyl Laurate". In Modelling, Identification, and Control. Calgary,AB,Canada: ACTAPRESS, 2010. http://dx.doi.org/10.2316/p.2010.702-085.
Testo completoRapporti di organizzazioni sul tema "Citronellol"
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Weislogel, Amy. Actualistic and Geochemical Modeling of Reservoir Rock, CO2 and Formation Fluid Interaction, Citronelle Oil Field, Alabama. Office of Scientific and Technical Information (OSTI), gennaio 2014. http://dx.doi.org/10.2172/1172596.
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