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Articoli di riviste sul tema "Cochlea"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Balkany, Thomas, Bruce J. Gantz, Ronald L. Steenerson, and Noel L. Cohen. "Systematic Approach to Electrode Insertion in the Ossified Cochlea." Otolaryngology–Head and Neck Surgery 114, no. 1 (1996): 4–11. http://dx.doi.org/10.1016/s0194-59989670275-9.

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Ossification of the fluid spaces of the cochlea occurs often in candidates for cochlear implantation, especially children. When noted before surgery on computerized tomography, ossification previously was thought to contraindicate cochlear implantation because of possible mechanical obstruction and uncertainty about the level of function that could be achieved by stimulating an ossified cochlea. However, during the preceding 6 years, techniques have been developed that permit implantation in ossified cochleas. We present a systematic approach that has been developed to treat the three clinical

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2

Mutalipova, G. A., D. N. Asretov, D. A. Temirova, et al. "Cochlear models used in cochlear implant research." CARDIOMETRY, no. 32 (August 25, 2024): 13–20. http://dx.doi.org/10.18137/cardiometry.2024.32.1320.

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Over the past few decades, cochlear implants have undergone significant changes due to intensive research through experimental and computational analysis. However, obtaining an accurate and reliable cochlear model remains an open issue. Invasive measurements on the human ear are hardly possible, and the only alternative is animal models, but even this is not an ideal option, as animal cochleae are anatomically significantly different from the human cochleae. In this context, an ear model based on the latest knowledge of the physiology and molecular principles of hearing will allow the study of

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3

Englisch, Colya N., Jakob Steinhäuser, Silke Wemmert, et al. "Immunohistochemistry Reveals TRPC Channels in the Human Hearing Organ—A Novel CT-Guided Approach to the Cochlea." International Journal of Molecular Sciences 24, no. 11 (2023): 9290. http://dx.doi.org/10.3390/ijms24119290.

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TRPC channels are critical players in cochlear hair cells and sensory neurons, as demonstrated in animal experiments. However, evidence for TRPC expression in the human cochlea is still lacking. This reflects the logistic and practical difficulties in obtaining human cochleae. The purpose of this study was to detect TRPC6, TRPC5 and TRPC3 in the human cochlea. Temporal bone pairs were excised from ten body donors, and the inner ear was first assessed based on computed tomography scans. Decalcification was then performed using 20% EDTA solutions. Immunohistochemistry with knockout-tested antibo

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4

Tröger, Andrea, Werner Bader, Timo Gottfried, et al. "Optimizing Factors in Murine Whole-Organ Cochlea Culture." International Journal of Molecular Sciences 26, no. 8 (2025): 3908. https://doi.org/10.3390/ijms26083908.

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In 2008, Hahn et al. presented a method for cultivating a 3D organ culture of the cochlea. Although this method is well established, it is currently only applied to early postnatal animals. Given the known differences in regeneration and repair abilities between early postnatal and adult mammalian cochleae, our goal was to further develop and optimize this method to extend it beyond early postnatal animals to include adult mammalian cochleae. After rapidly dissecting the cochlea, it is opened and placed in a neurotrophin-containing culture medium. The culture is then maintained at 32 °C in a r

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5

Yu, J.-F., K.-C. Lee, Y.-L. Wan, and Y.-C. Peng. "Curvature measurement of human bilateral cochleae." Journal of Laryngology & Otology 129, no. 11 (2015): 1085–90. http://dx.doi.org/10.1017/s0022215115002480.

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AbstractObjective:This study aimed to characterise the geometry of the human bilateral spiral cochlea by measuring curvature and length.Method:Eight subjects were recruited in this study. Magnetic resonance imaging was used to visualise the right and left cochlea. Visualisation of the cochlear spiral was enhanced by T2 weighting and further processing of the raw images. The spirals were divided into three segments: the basal turn, the middle turn and the apex turn. The length and curvature of each segment were non-invasively measured.Results:The mean left and right cochlear lengths were 3.11 c

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6

Dong, Wei, and Nigel P. Cooper. "An experimental study into the acousto-mechanical effects of invading the cochlea." Journal of The Royal Society Interface 3, no. 9 (2006): 561–71. http://dx.doi.org/10.1098/rsif.2006.0117.

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The active and nonlinear mechanical processing of sound that takes place in the mammalian cochlea is fundamental to our sense of hearing. We have investigated the effects of opening the cochlea in order to make experimental observations of this processing. Using an optically transparent window that permits laser interferometric access to the apical turn of the guinea-pig cochlea, we show that the acousto-mechanical transfer functions of the sealed (i.e. near intact) cochlea are considerably simpler than those of the unsealed cochlea. Comparison of our results with those of others suggests that

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7

Hosoya, Makoto, Masato Fujioka, Hideyuki Okano, and Kaoru Ogawa. "Distinct Expression Pattern of a Deafness Gene,KIAA1199, in a Primate Cochlea." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/1781894.

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Deafness is one of the most common types of congenital impairments, and at least half of the cases are caused by hereditary mutations. Mutations of the geneKIAA1199are associated with progressive hearing loss. Its expression is abundant in human cochlea, but interestingly the spatial expression patterns are different between mouse and rat cochleae; the pattern in humans has not been fully investigated. We performed immunohistochemical analysis of a nonhuman primate, common marmoset (Callithrix jacchus), cochlea with a KIAA1199-specific antibody. In the common marmoset cochlea, KIAA1199 protein

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8

Soliman, A. M. "An improved technique for the study of immunofluorescence using non-decalcified frozen guinea pig cochlea." Journal of Laryngology & Otology 102, no. 3 (1988): 215–18. http://dx.doi.org/10.1017/s0022215100104554.

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SummaryA technique for producing frozen sections from the non-decalcified guinea pig cochlea is described. The sections can be utilised or various immunofluorescent studies, including the detection of humoral anti-bodies against different cellular elements in patients with cochleo-vestibular disorders. The technique assures the preservation of the cochlear architecture and the tissue antigenicity, and it avoids damage to the fine cochlear structural details.

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9

Toulemonde, Philippine, Michaël Risoud, Pierre Emmanuel Lemesre, et al. "Evaluation of the Efficacy of Dexamethasone-Eluting Electrode Array on the Post-Implant Cochlear Fibrotic Reaction by Three-Dimensional Immunofluorescence Analysis in Mongolian Gerbil Cochlea." Journal of Clinical Medicine 10, no. 15 (2021): 3315. http://dx.doi.org/10.3390/jcm10153315.

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Cochlear implant is the method of choice for the rehabilitation of severe to profound sensorineural hearing loss. The study of the tissue response to cochlear implantation and the prevention of post-cochlear-implant damages are areas of interest in hearing protection research. The objective was to assess the efficacy of dexamethasone-eluting electrode array on endo canal fibrosis formation by three-dimensional immunofluorescence analysis in implanted Mongolian gerbil cochlea. Two trials were conducted after surgery using Mongolian gerbil implanted with dexamethasone-eluting or non-eluting intr

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10

Robles, Luis, and Mario A. Ruggero. "Mechanics of the Mammalian Cochlea." Physiological Reviews 81, no. 3 (2001): 1305–52. http://dx.doi.org/10.1152/physrev.2001.81.3.1305.

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In mammals, environmental sounds stimulate the auditory receptor, the cochlea, via vibrations of the stapes, the innermost of the middle ear ossicles. These vibrations produce displacement waves that travel on the elongated and spirally wound basilar membrane (BM). As they travel, waves grow in amplitude, reaching a maximum and then dying out. The location of maximum BM motion is a function of stimulus frequency, with high-frequency waves being localized to the “base” of the cochlea (near the stapes) and low-frequency waves approaching the “apex” of the cochlea. Thus each cochlear site has a c

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11

Moore, David R., Nina J. Rogers, and Stephen J. O'Leary. "Loss of Cochlear Nucleus Neurons following Aminoglycoside Antibiotics or Cochlear Removal." Annals of Otology, Rhinology & Laryngology 107, no. 4 (1998): 337–43. http://dx.doi.org/10.1177/000348949810700413.

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This study compared the effects of aminoglycoside ototoxicity and surgical ablation of the cochlea in infancy on the survival of neurons in the rat cochlear nucleus (CN). Ototoxicity was induced by a single, systemic dose of gentamicin sulfate and furosemide on postnatal day 6 (P6), P7, or P10, and assessed by the elevation of auditory brain stem response thresholds, as described in a companion paper. Unilateral cochlear removals were performed under Saffan anesthesia on P6, P9, and P12. Rats were painlessly sacrificed in adulthood, and the formalin-perfused brains and cochleas were embedded i

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12

Gupta, Ankur, Viktoria Schiel, Ritwija Bhattacharya, Kourosh Eftekharian, Anping Xia, and Peter L. Santa Maria. "Chemokine Receptor CCR2 Is Protective toward Outer Hair Cells in Chronic Suppurative Otitis Media." ImmunoHorizons 8, no. 9 (2024): 688–94. http://dx.doi.org/10.4049/immunohorizons.2400064.

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Abstract Chronic suppurative otitis media (CSOM) is a neglected disease that afflicts 330 million people worldwide and is the most common cause of permanent hearing loss among children in the developing world. Previously, we discovered that outer hair cell (OHC) loss occurred in the basal turn of the cochlea and that macrophages are the major immune cells associated with OHC loss in CSOM. Macrophage-associated cytokines are upregulated. Specifically, CCL-2, an important member of the MCP family, is elevated over time following middle ear infection. CCR2 is a common receptor of the MCP family a

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13

Lin, Wei-Ching, Anes Macic, and Jong-Hoon Nam. "Characterizing the primary resonator in the cochlea." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A308. http://dx.doi.org/10.1121/10.0027608.

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The cochlear traveling waves are explained by a bank of independent resonators coupled longitudinally by lymphatic fluids. Many cochlear models require at least two resonators to account for observed responses. To investigate the resonators in the cochlea, we used high-resolution optical coherence tomography to measure 2-D vibration patterns of the organ of Corti in acutely excised cochleae from young Mongolian gerbils. The excised tissues were acoustically stimulated. The transverse and radial vibrations of the basilar membrane (BM) and the tectorial membrane (TM) were obtained over their rad

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14

Szczepek, Agnieszka J., Tatyana Dudnik, Betül Karayay, Valentina Sergeeva, Heidi Olze, and Alina Smorodchenko. "Mast Cells in the Auditory Periphery of Rodents." Brain Sciences 10, no. 10 (2020): 697. http://dx.doi.org/10.3390/brainsci10100697.

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Mast cells (MCs) are densely granulated cells of myeloid origin and are a part of immune and neuroimmune systems. MCs have been detected in the endolymphatic sac of the inner ear and are suggested to regulate allergic hydrops. However, their existence in the cochlea has never been documented. In this work, we show that MCs are present in the cochleae of C57BL/6 mice and Wistar rats, where they localize in the modiolus, spiral ligament, and stria vascularis. The identity of MCs was confirmed in cochlear cryosections and flat preparations using avidin and antibodies against c-Kit/CD117, chymase,

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15

Sargsyan, Liana, Austin R. Swisher, Alisa P. Hetrick, and Hongzhe Li. "Effects of Combined Gentamicin and Furosemide Treatment on Cochlear Macrophages." International Journal of Molecular Sciences 23, no. 13 (2022): 7343. http://dx.doi.org/10.3390/ijms23137343.

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Combining aminoglycosides and loop diuretics often serves as an effective ototoxic approach to deafen experimental animals. The treatment results in rapid hair cell loss with extended macrophage presence in the cochlea, creating a sterile inflammatory environment. Although the early recruitment of macrophages is typically neuroprotective, the delay in the resolution of macrophage activity can be a complication if the damaged cochlea is used as a model to study subsequent therapeutic strategies. Here, we applied a high dose combination of systemic gentamicin and furosemide in C57 BL/6 and CBA/C

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16

Zhang, Guoping, Yiling Gao, Zhen Zhao, Ilmari Pyykko, and Jing Zou. "Low-Molecular-Weight Hyaluronic Acid Contributes to Noise-Induced Cochlear Inflammation." Audiology and Neurotology 28, no. 5 (2023): 380–93. http://dx.doi.org/10.1159/000530280.

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Introduction: Our previous work indicated that the activation of the Toll-like receptor (TLR) 4 signaling pathway contributed to noise-induced cochlear inflammation. Previous studies have reported that low-molecular-weight hyaluronic acid (LMW-HA) accumulates during aseptic trauma and promotes inflammation by activating the TLR4 signaling pathway. We hypothesized that LMW-HA or enzymes synthesizing or degrading HA might be involved in noise-induced cochlear inflammation. Methods: The present study included two arms. The first arm was the noise exposure study, in which TLR4, proinflammatory cyt

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17

Langman, Alan W., and Suzanne M. Quigley. "Accuracy of High-Resolution Computed Tomography in Cochlear Implantation." Otolaryngology–Head and Neck Surgery 114, no. 1 (1996): 38–43. http://dx.doi.org/10.1016/s0194-59989670281-4.

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Multichannel cochlear implants are a proven method for the auditory rehabilitation of individuals who have severe-to-profound sensorineural hearing loss. These devices typically require insertion into the scala tympani of the cochlea to provide auditory stimulations. A patent scala provides the best chance for an adequate insertion of the electrode array. Preoperative high-resolution computed tomography imaging has traditionally been used to determine the patency of the scala tympani. Its ability to accurately predict the patency of the cochlea has been questioned in several retrospective stud

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18

Ni, Guangjian, Stephen J. Elliott, Mohammad Ayat, and Paul D. Teal. "Modelling Cochlear Mechanics." BioMed Research International 2014 (2014): 1–42. http://dx.doi.org/10.1155/2014/150637.

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The cochlea plays a crucial role in mammal hearing. The basic function of the cochlea is to map sounds of different frequencies onto corresponding characteristic positions on the basilar membrane (BM). Sounds enter the fluid-filled cochlea and cause deflection of the BM due to pressure differences between the cochlear fluid chambers. These deflections travel along the cochlea, increasing in amplitude, until a frequency-dependent characteristic position and then decay away rapidly. The hair cells can detect these deflections and encode them as neural signals. Modelling the mechanics of the coch

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19

Martins, Maria Clara Iruzun, Travis Park, Rachel Racicot, and Natalie Cooper. "Intraspecific variation in the cochleae of harbour porpoises (Phocoena phocoena) and its implications for comparative studies across odontocetes." PeerJ 8 (April 13, 2020): e8916. http://dx.doi.org/10.7717/peerj.8916.

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In morphological traits, variation within species is generally considered to be lower than variation among species, although this assumption is rarely tested. This is particularly important in fields like palaeontology, where it is common to use a single individual as representative of a species due to the rarity of fossils. Here, we investigated intraspecific variation in the cochleae of harbour porpoises (Phocoena phocoena). Interspecific variation of cochlear morphology is well characterised among odontocetes (toothed whales) because of the importance of the structure in echolocation, but g

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20

Li, Jianan, Shuoshuo Kang, Haiqiao Du, et al. "Analysis of Cochlear Parameters in Paediatric Inner Ears with Enlarged Vestibular Aqueduct and Patent Cochlea." Journal of Personalized Medicine 12, no. 10 (2022): 1666. http://dx.doi.org/10.3390/jpm12101666.

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Is cochlear implant (CI) electrode selection for cochleae with an enlarged vestibular aqueduct (EVA) the same as that for patent cochleae with a normal inner ear structure? Preoperative high-resolution computed tomography (HRCT) images of 247 ears were assessed retrospectively. The A-value, B-value, and H-value were measured with OTOPLAN, and Bell curves were created to show the distribution. All ears with EVA were re-evaluated using a 3D slicer to confirm whether incomplete partition type II (IP II) existed. The Mann–Whitney U-test was applied to determine a statistically significant differen

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Swain, Santosh Kumar. "Cochlear deformities and its implication in cochlear implantation: a review." International Journal of Research in Medical Sciences 10, no. 10 (2022): 2339. http://dx.doi.org/10.18203/2320-6012.ijrms20222547.

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Hearing loss is one of the world’s leading causes of chronic health conditions. Cochlea plays a vital role in the hearing mechanisms and it converts sound energy into electrical stimuli which are transmitted to the brain through the neural pathway. The human cochlea is difficult to explore because of its vulnerability and bordering bony capsule. Congenital malformation of the inner ear or cochlea is an important cause of congenital sensorineural hearing loss. The deformity of the cochlea may result from arrested development of cochlea at different stages of fetal life or from abnormal developm

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Neagoș, Cristian Mircea, Eugenia Maria Domuța, Anca Gabriela Vlad, and Adriana Neagoș. "The Role of Imaging Investigations in Evaluation of Cochlear Dimensions in Candidates for Cochlear Implantation—Our Experience." Medicina 59, no. 12 (2023): 2086. http://dx.doi.org/10.3390/medicina59122086.

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Background and Objectives: The Cochlear implant is the first approved cranial nerve stimulator that works by directly stimulating the cochlear nerve. Various attempts have been made to evaluate the dimensions of the cochlea related to cochlear implantation. The preoperative computed tomographic examination is essential not only in assessing the anatomical aspect of the cochlea, but also in determining its dimensions to choose an appropriate electrode and obtain the best possible audiological performance. Materials and Methods: In the present paper, we aimed to carry out an observational study

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23

Deep, Nicholas, Baishakhi Choudhury, and J. Roland. "Auditory Brainstem Implantation: An Overview." Journal of Neurological Surgery Part B: Skull Base 80, no. 02 (2019): 203–8. http://dx.doi.org/10.1055/s-0039-1679891.

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AbstractAn auditory brainstem implant (ABI) is a surgically implanted central neural auditory prosthesis for the treatment of profound sensorineural hearing loss in children and adults who are not cochlear implant candidates due to a lack of anatomically intact cochlear nerves or implantable cochleae. The device consists of a multielectrode surface array which is placed within the lateral recess of the fourth ventricle along the brainstem and directly stimulates the cochlear nucleus, thereby bypassing the peripheral auditory system. In the United States, candidacy criteria for ABI include deaf

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WANNAPRASERT, THANAKUL, and NATHAN JEFFERY. "Variations of Mammalian Cochlear Shape in Relation to Hearing Frequency and Skull Size." Tropical Natural History 15, no. 1 (2015): 41–54. https://doi.org/10.58837/tnh.15.1.103087.

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The cochlea is the receptive organ of mammalian hearing and variations of its gross morphology have been linked to differences of hearing ability but as yet there has been little quantitative assessment of the proposed link, partly due to the difficulties of defining the complex geometry of the cochlea. The present study aims to quantitatively define the geometry and then determine whether adaptations of cochlear form are linked to the spatial limitations of the skull and hearing among a range of extant mammals. Advanced techniques in micro-CT imaging, 3D image visualization, geometric morphom

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Chen, Penghui, Yongchuan Chai, Haijin Liu, et al. "Postnatal Development of Microglia-Like Cells in Mouse Cochlea." Neural Plasticity 2018 (July 31, 2018): 1–5. http://dx.doi.org/10.1155/2018/1970150.

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Microglial cells are involved in surveillance and cleaning of the central nervous system. Recently, microglial-like cells (MLC) have been found in an adult cochlea and investigated for their role in cochlear inflammation. The presence and potential roles of MLCs during the development of the cochlea, however, remain unclear. In this study, immunostaining was performed using the MLC-specific marker IBA1 to characterize the presence, distribution, and morphology of MLCs in the developing cochlea. From P0 to P14, MLCs were present in a variety of cochlear regions including the modiolus, spiral la

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Zaluzec, Daniel, Joseph Ramzy, Robert Wotring, and Lincoln Gray. "Microsphere Determination of Cochlear Blood Flow in Chickens." Otolaryngology–Head and Neck Surgery 96, no. 4 (1987): 341–48. http://dx.doi.org/10.1177/019459988709600407.

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Chickens were injected with 9-micron-diameter radioactive microspheres. Cochleas were removed through the external auditory meatus, and the positions of all embedded microspheres were drawn under camera-lucida. Constant measurements of arterial pressures and postinjection blood-gas determinations confirmed that injections were made into normal circulatory systems. The averaged estimate of cochlear blood flow in chickens is 0.75 μl/min. Variability in these data from chickens is similar to that reported from mammals. A potentially important but puzzling observation is an inverse relationship be

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Lyu, Ah-Ra, Tae Hwan Kim, Sung Jae Park, et al. "Mitochondrial Damage and Necroptosis in Aging Cochlea." International Journal of Molecular Sciences 21, no. 7 (2020): 2505. http://dx.doi.org/10.3390/ijms21072505.

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Age-related hearing loss (ARHL) is an irreversible, progressive neurodegenerative disorder and is presently untreatable. Previous studies using animal models have suggested mitochondrial damage and programmed cell death to be involved with ARHL. Thus, we further investigated the pathophysiologic role of mitochondria and necroptosis in aged C57BL/6J male mice. Aged mice (20 months old) exhibited a significant loss of hearing, number of hair cells, neuronal fibers, and synaptic ribbons compared to young mice. Ultrastructural analysis of aged cochleae revealed damaged mitochondria with absent or

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Balkany, Thomas, Bruce Gantz, and Joseph B. Nadol. "Multichannel Cochlear Implants in Partially Ossified Cochleas." Annals of Otology, Rhinology & Laryngology 97, no. 5_suppl2 (1988): 3–7. http://dx.doi.org/10.1177/00034894880975s201.

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Deposition of bone within the fluid spaces of the cochlea is encountered commonly in cochlear implant candidates and previously has been considered a relative contraindication to the use of multichannel intracochlear electrodes. This contraindication has been based on possible mechanical difficulty with electrode insertion as well as uncertainty about the potential benefit of the multichannel device in the patient. Fifteen profoundly deaf patients with partial ossification of the basal turn of the cochlea received implants with long intracochlear electrodes (11, Nucleus; 1, University of Calif

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Keppeler, Daniel, Christoph A. Kampshoff, Anupriya Thirumalai, et al. "Multiscale photonic imaging of the native and implanted cochlea." Proceedings of the National Academy of Sciences 118, no. 18 (2021): e2014472118. http://dx.doi.org/10.1073/pnas.2014472118.

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The cochlea of our auditory system is an intricate structure deeply embedded in the temporal bone. Compared with other sensory organs such as the eye, the cochlea has remained poorly accessible for investigation, for example, by imaging. This limitation also concerns the further development of technology for restoring hearing in the case of cochlear dysfunction, which requires quantitative information on spatial dimensions and the sensorineural status of the cochlea. Here, we employed X-ray phase-contrast tomography and light-sheet fluorescence microscopy and their combination for multiscale a

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Jeong, Sung-Wook, and Lee-Suk Kim. "A New Classification of Cochleovestibular Malformations and Implications for Predicting Speech Perception Ability after Cochlear Implantation." Audiology and Neurotology 20, no. 2 (2015): 90–101. http://dx.doi.org/10.1159/000365584.

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Objectives: The aims of this study were to introduce a new classification of cochleovestibular malformation (CVM) and to investigate how well this classification can predict speech perception ability after cochlear implantation in children with CVM. Methods: Fifty-nine children with CVM who had used a cochlear implant for more than 3 years were included. CVM was classified into 4 subtypes based on the morphology of the cochlea and the modiolus on temporal bone computed tomography (TBCT): normal cochlea and normal modiolus (type A, n = 16), malformed cochlea and partial modiolus (type B, n = 31

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Barker, Emma, Keith Trimble, Harley Chan, et al. "Intraoperative use of cone-beam computed tomography in a cadaveric ossified cochlea model." Otolaryngology–Head and Neck Surgery 140, no. 5 (2009): 697–702. http://dx.doi.org/10.1016/j.otohns.2008.12.046.

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Objectives: To describe a cadaveric temporal bone model of labyrinthitis ossificans and investigate the utility of intraoperative cone-beam computed tomography (CBCT) in the facilitating cochlear implantation. Design: Cadaveric temporal bone study. Methods: Five cadaveric heads had cement introduced into the 10 cochleas. CBCT and a conventional CT scan were compared to assess the extent of cochlear obliteration. The cement was drilled-out (under CBCT guidance, if required) and cochlear implant electrode arrays (from 3 different manufacturers) inserted. Results: CBCT images demonstrated tempora

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Xu, D.-Y., Q.-X. Zhang, Y.-Q. Ma, X.-L. Zheng, and S.-X. Liu. "Immunohistochemical localisation of endothelin receptor subtypes in the cochlear lateral wall." Journal of Laryngology & Otology 124, no. 10 (2010): 1073–77. http://dx.doi.org/10.1017/s0022215110001428.

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AbstractObjective:Endothelin has many biological activities, including regulation of the functions of the cochlear lateral wall. The present study aimed to analyse the expression of endothelin receptors in the cochlear lateral wall, and to investigate the significance of such receptors in maintaining the homeostatic environment of the cochlea.Methods:The cochleae of healthy guinea pigs were fixed, decalcified, embedded in paraffin and serially sectioned. Expression of the endothelin receptor subunits A and B in the cochlear lateral wall was examined using an immunohistochemical technique.Resul

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Massager, Nicolas, Ouzi Nissim, Carine Delbrouck, et al. "Irradiation of cochlear structures during vestibular schwannoma radiosurgery and associated hearing outcome." Journal of Neurosurgery 107, no. 4 (2007): 733–39. http://dx.doi.org/10.3171/jns-07/10/0733.

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Abstract (sommario):

Object The purpose of this study was to measure the dose of radiation delivered to the cochlea during a Gamma knife surgery (GKS) procedure for treatment of patients with vestibular schwannomas (VSs), and to analyze the relationship between cochlear irradiation and the hearing outcome of these patients. Methods Eighty-two patients with VSs were treated with GKS using a marginal dose of 12 Gy. No patient had neurofibromatosis Type 2 disease, and all had a Gardner–Robertson hearing class of I to IV before treatment, and a radiological and audiological follow-up of at least 1-year after GKS. The

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Kuzovkov, V. E., A. S. Lilenko, S. B. Sugarova, V. A. Tanaschishina, P. R. Kharitonova, and Yu S. Korneva. "Preoperative and intraoperative measurements of ossification length of cochlea canal." Russian Otorhinolaryngology 23, no. 1 (2024): 31–36. http://dx.doi.org/10.18692/1810-4800-2024-1-31-36.

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Cochlear implantation is a high-tech method of rehabilitation of patients with progressive hearing loss, up to deafness. Ossification of the cochlear spiral canal is no longer considered a surgical contraindication for cochlear implantation (CI). However, performing the surgical stage of CI in patients with ossification of the cochlea spiral canal may be accompanied by a number of difficulties. The advanced process of ossification and remodeling can lead to significant difficulty in inserting the electrode into the cochlea, leading to the risk of incomplete insertion. Today, the introduction o

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Carswell, V., J. A. Crowther, R. Locke, W. Taylor, and G. Kontorinis. "Cochlear patency following translabyrinthine vestibular schwannoma resection: implications for hearing rehabilitation." Journal of Laryngology & Otology 133, no. 7 (2019): 560–65. http://dx.doi.org/10.1017/s0022215119001087.

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AbstractObjectiveTo examine when cochlear fibrosis occurs following a translabyrinthine approach for vestibular schwannoma resection, and to determine the safest time window for potential cochlear implantation in cases with a preserved cochlear nerve.MethodsThis study retrospectively reviewed the post-operative magnetic resonance imaging scans of patients undergoing a translabyrinthine approach for vestibular schwannoma resection, assessing the fluid signal within the cochlea. Cochleae were graded based on the Isaacson et al. system (from grade 0 – no obstruction, to grade 4 – complete obliter

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Pan, Dorothy W., Jinkyung Kim, Patricia M. Quiñones, Anthony J. Ricci, Brian E. Applegate, and John S. Oghalai. "Cochlear Mechanics Are Preserved After Inner Ear Delivery of Gold Nanoparticles." International Journal of Molecular Sciences 26, no. 1 (2024): 126. https://doi.org/10.3390/ijms26010126.

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Abstract (sommario):

Novel therapeutic delivery systems and delivery methods to the inner ear are necessary to treat hearing loss and inner ear disorders. However, numerous barriers exist to therapeutic delivery into the bone-encased and immune-privileged environment of the inner ear and cochlea, which makes treating inner ear disorders challenging. Nanoparticles (NPs) are a type of therapeutic delivery system that can be engineered for multiple purposes, and posterior semicircular canal (PSCC) infusion is a method to directly deposit them into the cochlea. We sought to assess PSCC infusion of gold NPs into the co

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Kim, Seong Min, Ho Yun Lee, Han Kyu Kim, and Joseph M. Zabramski. "Cochlear line: a novel landmark for hearing preservation using the anterior petrosal approach." Journal of Neurosurgery 123, no. 1 (2015): 9–13. http://dx.doi.org/10.3171/2014.12.jns132840.

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Abstract (sommario):

OBJECT The goal of this study was to develop a practical landmark for the safe and easy identification of the cochlea when performing anterior petrosectomy based on cadaver dissection results. METHODS The cochlear line was defined as the line drawn from the crossing point between the greater superficial petrosal nerve (GSPN) and the petrous internal carotid artery to the line drawn over the apex of the superior circumference of the dura of the internal auditory canal at a right angle. The validity of the cochlear line marking the anteromedial perimeter of the cochlea at the angle of the GSPN a

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Perényi, Ádám, Roland Nagy, Bence Horváth, et al. "Új műtéti képalkotó lehetőség a belsőfül-implantátum elektródasorának dinamikus helyzetmeghatározására." Orvosi Hetilap 162, no. 22 (2021): 878–83. http://dx.doi.org/10.1556/650.2021.32085.

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Abstract (sommario):

Összefoglaló. Bevezetés: A cochlearis implantátum egy műtétileg behelyezett elektromos eszköz, amely az akusztikus hanghullámokat elektromos jelekké alakítja, közvetlenül a hallóideget stimulálja, így segíti a súlyos fokú hallássérüléssel vagy teljes hallásvesztéssel élők életét. Cochlearis implantációt követően a legjobb rehabilitációs eredmény elérésének technikai feltétele többek között az esetre szabott elektródaválasztás és az elektródasor teljes, kontrollált, szövődménymentes bejuttatása a scala tympaniba, miközben a cochlea belső struktúrája a lehető legkisebb mértékben sérül. A rutin i

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Swain, Santosh Kumar. "Vertigo following cochlear implantation: a review." International Journal of Research in Medical Sciences 10, no. 2 (2022): 572. http://dx.doi.org/10.18203/2320-6012.ijrms20220310.

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Abstract (sommario):

Cochlear implantation may cause a detrimental effect on vestibular function and residual hearing. A significant number of patients with a cochlear implant present with vertigo. There are several mechanisms for dizziness following cochlear implantations. The causes may be surgical trauma, disruption of normal cochlear physiology, or ensuing endolymphatic hydrops. Vibratory trauma affecting the cochlea during cochleostomy plays a vital role in causing paroxysmal vertigo in patients with a cochlear implant. In addition, the vibrations affecting the cochlea are enough to dislodge otoconia particle

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Köles, László, Judit Szepesy, Eszter Berekméri, and Tibor Zelles. "Purinergic Signaling and Cochlear Injury-Targeting the Immune System?" International Journal of Molecular Sciences 20, no. 12 (2019): 2979. http://dx.doi.org/10.3390/ijms20122979.

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Abstract (sommario):

Hearing impairment is the most common sensory deficit, affecting more than 400 million people worldwide. Sensorineural hearing losses currently lack any specific or efficient pharmacotherapy largely due to the insufficient knowledge of the pathomechanism. Purinergic signaling plays a substantial role in cochlear (patho)physiology. P2 (ionotropic P2X and the metabotropic P2Y) as well as adenosine receptors expressed on cochlear sensory and non-sensory cells are involved mostly in protective mechanisms of the cochlea. They are implicated in the sensitivity adjustment of the receptor cells by a K

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Hang, Jianfeng, Wenlu Pan, Aoshuang Chang, et al. "Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats." Neural Plasticity 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/4545826.

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Abstract (sommario):

Prestin is the motor protein expressed in the cochlear outer hair cells (OHCs) of mammalian inner ear. The electromotility of OHCs driven by prestin is responsible for the cochlear amplification which is required for normal hearing in adult animals. Postnatal expression of prestin and activity of OHCs may contribute to the maturation of hearing in rodents. However, the temporal and spatial expression of prestin in cochlea during the development is not well characterized. In the present study, we examined the expression and function of prestin from the OHCs in apical, middle, and basal turns of

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Schurzig, Daniel, Max Eike Timm, Cornelia Batsoulis, et al. "A Novel Method for Clinical Cochlear Duct Length Estimation toward Patient-Specific Cochlear Implant Selection." OTO Open 2, no. 4 (2018): 2473974X1880023. http://dx.doi.org/10.1177/2473974x18800238.

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Abstract (sommario):

Objective In the field of cochlear implantation, the current trend toward patient-specific electrode selection and the achievement of optimal audiologic outcomes has resulted in implant manufacturers developing a large portfolio of electrodes. The aim of this study was to bridge the gap between the known variability of cochlea length and this electrode portfolio. Design Retrospective analysis on cochlear length and shape in micro–computed tomography and cone beam computed tomography data. Setting Tertiary care medical center. Subjects and Methods A simple 2-step approach was developed to accur

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Salkim, Enver. "Effect of Dielectric Properties of Cochlea on Electrode Insertion Guidance Based on Impedance Variation." Applied Sciences 14, no. 22 (2024): 10408. http://dx.doi.org/10.3390/app142210408.

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Abstract (sommario):

The cochlear neuromodulator provides substantial auditory perception to those with impaired hearing. The accurate insertion of electrodes into the cochlea is an important factor, as misplaced may lead to further damage. The impedance measurement may be used as a marker of the electrode insertion guidance. It is feasible to investigate the impact of the dielectric properties of the cochlea tissue layers on the electrode insertion guidance using sophisticated bio-computational methods that are impractical or impossible to perform in cochlear implant (CI) patients. Although previous modeling appr

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Bassiouni, Mohamed, Alina Smorodchenko, Heidi Olze, and Agnieszka J. Szczepek. "Identification and Characterization of TMEM119-Positive Cells in the Postnatal and Adult Murine Cochlea." Brain Sciences 13, no. 3 (2023): 516. http://dx.doi.org/10.3390/brainsci13030516.

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Abstract (sommario):

Transmembrane protein 119 (TMEM119) is expressed in a subset of resident macrophage cells of the brain and was proposed as a marker for native brain microglia. The presence of cells expressing TMEM119 in the cochlea has not yet been described. Thus, the present study aimed to characterize the TMEM119-expressing cells of the postnatal and adult cochlea, the latter also after noise exposure. Immunofluorescent staining of cochlear cryosections detected TMEM119 protein in the spiral limbus fibrocytes and the developing stria vascularis at postnatal Day 3. Applying the macrophage marker Iba1 reveal

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Honda, Tomoko, Norihito Kawasaki, Rei Yanagihara, et al. "Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9)." PLOS ONE 17, no. 7 (2022): e0268485. http://dx.doi.org/10.1371/journal.pone.0268485.

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Abstract (sommario):

Late-onset non-syndromic autosomal dominant hearing loss 9 (DFNA9) is a hearing impairment caused by mutations in the coagulation factor C homology gene (COCH). COCH encodes for cochlin, a major component of the cochlear extracellular matrix. Though biochemical and genetic studies have characterized the properties of wild-type and mutated cochlins derived from DFNA9, little is known about the underlying pathogenic mechanism. In this study, we established a cochlin reporter cell, which allowed us to monitor the interaction of cochlin with its ligand(s) by means of a β-galactosidase assay. We fo

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Ren, DongDong, JingWU Sun, GuangLun Wan, Feng Yang, and Fang Shen. "Influence of carbon dioxide laser irradiation on the morphology and function of guinea pig cochlea." Journal of Laryngology & Otology 119, no. 9 (2005): 684–92. http://dx.doi.org/10.1258/0022215054797899.

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Abstract (sommario):

Both experimental and clinical studies have demonstrated that carbon dioxide laser is suitable for stapedotomy. The aim of this study was to investigate morphological, electrophysiological and functional changes in the inner ear after irradiation with CO2 laser set with different energy parameters.A cochleostomy in the basal cochlear turn of guinea pig cochleae was performed with CO2 laser of 1, 2 and 3 w, respectively. The cochleae were removed three weeks after laser irradiation. The auditory evoked brainstem response (ABR) was measured before and after laser application and immediately befo

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XU, LIFU, XINSHENG HUANG, NA TA, ZHUSHI RAO, and JIABIN TIAN. "FINITE ELEMENT MODELING OF THE HUMAN COCHLEA USING FLUID–STRUCTURE INTERACTION METHOD." Journal of Mechanics in Medicine and Biology 15, no. 03 (2015): 1550039. http://dx.doi.org/10.1142/s0219519415500396.

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Abstract (sommario):

In this paper, a 3D finite element (FE) model of human cochlea is developed. This passive model includes the structure of oval window, round window, basilar membrane (BM) and cochlear duct which is filled with fluid. Orthotropic material property of the BM is varying along its length. The fluid–structure interaction (FSI) method is used to compute the responses in the cochlea. In particular, the viscous fluid element is adopted for the first time in the cochlear FE model, so that the effects of shear viscosity in the fluid are considered. Results on the cochlear impedance, BM response and intr

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Uenaka, Miku, Hidekazu Nagamura, Aya Okamoto, Shizuko Hiryu, Kohta I. Kobayasi, and Yuta Tamai. "Feasibility evaluation of transtympanic laser stimulation of the cochlea from the outer ear." Journal of the Acoustical Society of America 152, no. 3 (2022): 1850–55. http://dx.doi.org/10.1121/10.0014241.

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Abstract (sommario):

Infrared laser stimulation has been studied as an alternative approach to auditory prostheses. This study evaluated the feasibility of infrared laser stimulation of the cochlea from the outer ear, bypassing the middle ear function. An optic fiber was inserted into the ear canal, and a laser was used to irradiate the cochlea through the tympanic membrane in Mongolian gerbils. A pulsed infrared laser (6.9 mJ/cm2) and clicking sound (70 peak-to-peak equivalent sound pressure level) were presented to the animals. The amplitude of the laser-evoked cochlear response was systematically decreased foll

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Balkany, Thomas, Annelle V. Hodges, Martin Whitehead, Faramarz Memari, and Glen K. Martin. "Cochlear Endoscopy with Preservation of Hearing in Guinea Pigs." Otolaryngology–Head and Neck Surgery 111, no. 4 (1994): 439–45. http://dx.doi.org/10.1177/019459989411100408.

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Abstract (sommario):

Advances in fiberoptic technology have revolutionized the way many disorders are treated by otolaryngologists. We have previously described our experiences with cochlear endoscopy during cochlear Implantation. However, endoscopy of the functioning cochlea has not previously been reported. To test the hypothesis that endoscopy of the guinea pig cochlea is possible without catastrophic loss of auditory function, we subjected 20 ears of 10 Hartley-strain albino guinea pigs to limited endoscopy of the cochlea through the round window with evaluation of distortion product otoacoustic emissions and

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Fernando, Adrian F., Brian Joseph dG De Jesus, Alejandro P. Opulencia, Gil M. Maglalang, and Antoio H. Chua. "An Anatomical Study of the Cochlea among Filipinos using High-Resolution Computed Tomography Scans." Philippine Journal of Otolaryngology-Head and Neck Surgery 26, no. 1 (2011): 6–9. http://dx.doi.org/10.32412/pjohns.v26i1.591.

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Abstract (sommario):

Objective: To describe the cochlear anatomy among Filipinos through high resolution computed tomography (HRCT) imaging.  Methods: Design: Retrospective Study Setting: Tertiary Private University Hospital Patients: Cochlear images retrospectively obtained from computed tomography (CT) scans of subjects who underwent cranial, facial, paranasal sinus and temporal bone computed tomography from October 2009 to July 2010 were reconstructed and analyzed.  Results: 388 cochlear images were obtained from the scans of 194 subjects (101 males and 93 females

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