Bibliografie tematiche / Combined or multimodal treatments

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Letteratura scientifica selezionata sul tema "Combined or multimodal treatments"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 18 febbraio 2022

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Articoli di riviste sul tema "Combined or multimodal treatments"

Carrillo, Jose, Naveed Wagle, Garni Barkhoudarian, Daniel Kelly, Annie Heng, Jaya Gill, Tiffany Juarez e Santosh Kesari. "MNGI-05. COMBINED MULTIMODAL TREATMENT REGIMEN IN RECURRENT MENINGIOMAS". Neuro-Oncology 21, Supplement_6 (novembre 2019): vi140. http://dx.doi.org/10.1093/neuonc/noz175.587.

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Abstract Meningiomas are the most common primary brain tumor, subsequent tumor progression can be problematic for surgical treatment options based upon location. Currently there is limited activity of various single agent medical therapies. We evaluated a combined treatment modality in recurrent Meningiomas. Patients were consented to NOC study protocol JWCI-17–0401 in this retrospective analysis. Treatment consisted of combination Octreotide LAR, Everolimus, Hydroxyurea, and Mifepristone. Patient characteristics in the combined treatment meningioma group (n=12) had a median age 60, 50% male, 47% WHO grade I, 37% WHO grade II, 11% WHO grade III, 67% skull base location, median number of recurrences is 2.2, with median number of surgeries of 1.7. Total comparison meningioma patients (n=19) with median age 62, 42% male, 42% WHO grade I, 50% WHO grade II, 17% WHO grade III, 58% skull base location, median number of recurrences is 2.2, with median number of surgeries of 2.2. Median PFS in recurrence prior to initiation of multimodal combined therapy, mPFS=283 days. Median PFS with subsequent multimodal combined therapy, mPFS=318 days. Multimodal therapy may prolong mPFS in recurrent meningiomas. Our pilot data supports further clinical trials in combined multimodal treatments.

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D’Amico, Agata Grazia, Grazia Maugeri, Luca Vanella, Valeria Pittalà, Dora Reglodi e Velia D’Agata. "Multimodal Role of PACAP in Glioblastoma". Brain Sciences 11, n. 8 (28 luglio 2021): 994. http://dx.doi.org/10.3390/brainsci11080994.

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Glioblastoma multiforme (GBM) is the deadliest form of brain tumors. To date, the GBM therapeutical approach consists of surgery, radiation-therapy and chemotherapy combined with molecules improving cancer responsiveness to treatments. In this review, we will present a brief overview of the GBM classification and pathogenesis, as well as the therapeutic approach currently used. Then, we will focus on the modulatory role exerted by pituitary adenylate cyclase-activating peptide, known as PACAP, on GBM malignancy. Specifically, we will describe PACAP ability to interfere with GBM cell proliferation, as well as the tumoral microenvironment. Considering its anti-oncogenic role in GBM, synthesis of PACAP agonist molecules may open new perspectives for combined therapy to existing gold standard treatment.

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AJISAKA, Hideyuki, Yutaka YOSHIMITSU, Yoshiaki ISOBE e Yasuo TAKESHITA. "MULTIMODAL TREATMENT COMBINED WITH HYPERTHERMIA FOR MALIGNANCIES". Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 60, n. 2 (1999): 351–58. http://dx.doi.org/10.3919/jjsa.60.351.

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Levy, Florence. "Implications for Australia of the Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder". Australian & New Zealand Journal of Psychiatry 35, n. 1 (febbraio 2001): 45–48. http://dx.doi.org/10.1046/j.1440-1614.2001.00850.x.

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Objectives: This paper reviews the implications of the large-scale USA Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (MTA) by the MTA Cooperative group for planning of clinical services for children with attention deficit hyperactivity disorder in Australia. Method: The MTA study findings of no significant difference between active medication treatment alone, and combined medication combined with behaviour therapy treatments, on core symptom outcomes, are examined. Service traditions, workforce issues, diagnostic and ethical and philosophical considerations are discussed in relation to their impact on service planning in Australia. Implications of pharmacogenomic research are examined. Ethical and philosophical questions are raised in relation to the use of stimulant medications for subthreshold symptoms and for socialization of children. Results: A critical evaluation of results reveals that combined treatments allow the use of lower medication doses, and that multimodal treatments are effective for comorbid symptoms. Completion of the Human Genome Project promises increasing technological advances. Arguments for and against a technological approach to child rearing are posited. Conclusions: The MTA study raises not just service planning questions, but also important ethical and philosophical considerations about optimal degree of medicalization of services in an increasingly technological society. Child psychiatrists will be required to have an understanding of technological developments if they wish to contribute to future debates.

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Carvalho, M., D. Estevens e O. Tur. "Efficacy of Combined Treatments, Psychological and Pharmacological, for Depression in Adults". European Psychiatry 24, S1 (gennaio 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70938-1.

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According to the state of the art, combined treatments for depression are more efficacious than a unique approach. However, studies on the efficacy of different psychological treatments are scarce. We will present the results of an on-going research, carried out with the main purpose of analysing the efficacy of two psychological empirically validated treatments for depression, Cognitive-Behavioral Therapy (CBT) and Interpersonnal Therapy (IPT), combined with psychopharmacological approach. A sample of 30 adult females will be randomly assigned to one of three conditions: 1) CBT and pharmacological treatment; 2) IPT and pharmacological treatment; and 3) only pharmacological treatment. A multimodal assessment matrix will be used to evaluate depression, suicidal ideation and intention, and individual, social, and environmental factors commonly related to the onset of major depression, namely hopelessness and pessimism, cognitive processing, interpersonal relations, life events, before, at the end of treatments, and at follow-up. We expect that both combined approaches will be more efficacious in the reduction of depressive symptoms, including suicidal behaviours, compared to the pharmacological approach. We also expect to understand the sensitivity to change of the assessed psychological processes underlying each form of psychotherapy.

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Kazdin, Alan E. "Combined and Multimodal Treatments in Child and Adolescent Psychotherapy: Issues, Challenges, and Research Directions". Clinical Psychology: Science and Practice 3, n. 1 (marzo 1996): 69–100. http://dx.doi.org/10.1111/j.1468-2850.1996.tb00059.x.

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Tang, Zhao-You, e Giammaria Fiorentini. "Hepatoma Today: Therapeutic Experiences of Multimodal Approach". Tumori Journal 79, n. 3 (giugno 1993): 166–69. http://dx.doi.org/10.1177/030089169307900302.

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Aims and Background Hepatocellular carcinoma (HCC) ranks third of cancer deaths in China, it kills 100,000 patients every year. In Italy HCC is an increasing malignant tumor and kills about 7000 patients every year. Fortunately, due to a multimodal approach to the treatment of this fatal disease, HCC has been changed from « Incurable » to « partly curable ». The authors report and comment the methods and the strategies that have been used to increase the cure-rate of HCC. Methods The actual approaches, developed in the last thirty years mainly in China, included: screening of cirrhotic patients, early resection, new surgical criteria for cirrhotic liver, early detection of subclinical recurrence and re-resection, multimodality treatment for cytoreduction of huge HCC, sequential resection after cytoreduction of unresectable HCC, targeting therapy using radiolabelled antibodies and lipiodol, transarterial embolization, radiotherapy combined with Chinese herbs, other regional cancer therapy and biological response modifiers. Results Are that these methods have reached a marked increase series 5-year survival rate and number of 5-year survivors in more expert institutions. Conclusions We conclude that further biological and genetic studies on HCC are warranted and that it is mandatory to perform large clinical randomized trials comparing the more promising treatments.

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Rodrigo-Yanguas, Maria, Marina Martin-Moratinos, Angela Menendez-Garcia, Carlos Gonzalez-Tardon, Ana Royuela e Hilario Blasco-Fontecilla. "A Virtual Reality Game (The Secret Trail of Moon) for Treating Attention-Deficit/Hyperactivity Disorder: Development and Usability Study". JMIR Serious Games 9, n. 3 (1 settembre 2021): e26824. http://dx.doi.org/10.2196/26824.

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Background Attention-deficit/hyperactivity disorder (ADHD) affects between 4% and 8% of children worldwide. The treatment of choice is multimodal treatment. Multimodal interventions for ADHD may be improved by incorporating new treatments, such as treatment via serious video games. The Secret Trail of Moon (TSTM) is a virtual reality serious video game that was designed for cognitive training related to core ADHD symptoms and executive dysfunction. Objective We aimed to describe the development and usability of TSTM. Methods The usability study included 37 children and adolescents who tested TSTM during the early usability stage (preinclusion) of a randomized controlled clinical trial for testing the effectiveness of TSTM. Chi-square tests were performed to compare patients with ADHD (ADHD combined subtype vs inattentive subtype) and to compare frequent and infrequent video game players in the second study. We used SPSS version 20 for Macintosh (IBM Corporation). Results A total of 31/37 (86%) and 30/37 (83%) of participants liked playing TSTM and wanted to continue playing TSTM, respectively. Further, 5/37 (14%) of participants reported that they experienced either perceived dizziness or virtual reality motion sickness. We found no statistically significant differences after comparing the ADHD combined subtype to the inattentive subtype and frequent video game players to infrequent video game players. Conclusions Serious video games, such as TSTM, may complement the current multimodal approach for treating ADHD. Trial Registration ClinicalTrials.gov NCT04355065; https://clinicaltrials.gov/ct2/show/NCT04355065

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Han, Charles C., Davin Prasetyo e Gavin M. Wright. "Endobronchial Palliation Using Nd:YAG Laser Is Associated with Improved Survival when Combined with Multimodal Adjuvant Treatments". Journal of Thoracic Oncology 2, n. 1 (gennaio 2007): 59–64. http://dx.doi.org/10.1097/jto.0b013e31802bff2d.

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Bernstein, Cheryl, Andrea G. Gillman, Di Zhang, Anna E. Bartman, Jong-Hyeon Jeong e Ajay D. Wasan. "Identifying Predictors of Recommendations for and Participation in Multimodal Nonpharmacological Treatments for Chronic Pain Using Patient-Reported Outcomes and Electronic Medical Records". Pain Medicine 21, n. 12 (25 giugno 2020): 3574–84. http://dx.doi.org/10.1093/pm/pnaa203.

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Abstract Objective High-quality chronic pain care emphasizes multimodal treatments that include medication and nonpharmacological treatments. But it is not clear which patients will participate in nonpharmacological treatments, such as physical therapy or mental health care, and previous research has shown conflicting evidence. Methods We used the Patient Outcomes Repository for Treatment (PORT) registry, which combines patient-reported outcomes data with electronic medical records. In this retrospective observational study, we performed two separate multinomial regression analyses with feature selection to identify PORT variables that were predictive of 1) recommendation of a nonpharmacological treatment by the provider and 2) patient participation in nonpharmacological treatments. Two hundred thirty-six patients were recommended (REC) or not recommended (NO REC) a nonpharmacological treatment, and all REC patients were classified as participating (YES) or not participating (NO) in the recommendations. Results Female gender and a diagnosis of Z79 “Opioid drug therapy” were significant positive and negative predictors of nonpharmacological treatment recommendations, respectively. Schedule II opioid use at initial presentation and recommendations for rehabilitation therapy were significant predictors of nonparticipation. Conclusions Patients using opioids are less likely to be recommended nonpharmacological treatments as part of multimodal chronic pain care and are less likely to participate in nonpharmacological treatments once recommended. Males are also less likely to be recommended nonpharmacological treatments. Patients referred for rehabilitation therapies are less likely to comply with those recommendations. We have identified patients in vulnerable subgroups who may require additional resources and/or encouragement to comply with multimodal chronic pain treatment recommendations.

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Più fonti

Tesi sul tema "Combined or multimodal treatments"

Amado, Luz Laura. "Eficacia relativa y diferencial de una intervención combinada versus farmacológica para el Trastorno por Déficit de Atención con Hiperactividad en la infancia". Doctoral thesis, Universitat Ramon Llull, 2012. http://hdl.handle.net/10803/83710.

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El TDAH és un trastorn neuroevolutiu de l’atenció i la impulsivitat de naturalesa crònica que afecta un 4% de la població i que freqüentment s’associa amb altres trastorns, com els problemes de conducta i les dificultats en l’aprenentatge. Actualment hi ha base empírica sobre el seu origen genètic i biològic, encara que el seu curs evolutiu i el seu pronòstic estan molt influenciats per factors ambientals. És per això que un abordatge adequat del procés d’avaluació i d’intervenció d’aquest trastorn ha de contemplar de forma primerenca els contextos en què el nen es desenvolupa (escola, família i comunitat) i ha de comptar amb un equip multidisciplinari. En aquesta línia, las modalitats d’intervenció que han evidenciat ser més efectives són les medicacions psicoestimulants, les intervencions psicosocials i els tractaments que combinen ambdues modalitats terapèutiques. L’estimulant més utilitzat per al TDAH, el metilfenidat, és el fàrmac més prescrit en psiquiatria infantil i s’ha constatat la seva efectivitat de forma reiterada. No obstant això, s’ha d’administrar amb cautela perquè presenta limitacions que a vegades no en compensen l’administració, com el efectes no desitjats, el desconeixement sobre els efectes a llarg termini o els escassos estudis sobre eficàcia i seguretat en nens preescolars. Aquests troballes ens fan considerar les intervencions psicosocials, que també són una bona opció terapèutica. Les intervencions psicosocials validades empíricament serveixen d’entrenament a pares i mestres per manejar el trastorn, com també al mateix nen, tot i que en menor mesura, per exercitar les seves habilitats socioemocionals. La finalitat d’aquestes teràpies és que paral•lelament o tres la formació, s’implementen intervencions conductuals, cognitiu-conductuals, escolars i sòcio-emocionals en els contexts naturals del nen. Encara que està provada la eficàcia d’aquestes modalitat d’intervenció de forma aïllada, s’han trobat millores superiors amb els tractaments combinats o multimodals, que cobren un ampli ventall de dificultats i plànols de funcionament, permetent en ocasions reduir la dosi de medicació amb un manteniment dels efectes positius. Però, malauradament, encara s’observa una relativa carència d’estudis que incloguin tractaments combinats per al TDAH infantil, si més no a España. En el millor del casos, les intervencions han estat breus i intensives. Tanmateix, no s’han publicat estudis sobre l’eficàcia d’aquestes intervencions per millorar variables com el clima escolar i familiar d’aquests nens. L’objectiu, doncs, d’aquest projecte és analitzar l’eficàcia relativa i diferencial d’un tractament combinat (medicació estimulant + entrenament a pares i mestres) versus un de farmacològic, durant un curs escolar, per millorar diverses variables relacionades amb el nen hiperactiu, com també amb els seus mestres i pares (símptomes, rendiment acadèmic, clima escolar i familiar, autoeficàcia percebuda i coneixements sobre TDAH).
El TDAH es un trastorno neuro-evolutivo de la atención, la actividad y la impulsividad de naturaleza crónica, que afecta a un 4% de la población, asociándose frecuentemente con otros trastornos, como los problemas de conducta y las dificultades de aprendizaje. En la actualidad, hay evidencia empírica sobre su origen genético y biológico, aunque su curso evolutivo y pronóstico están enormemente influidos por factores ambientales. De ahí que un adecuado abordaje del proceso de evaluación e intervención de este trastorno deba contemplar de forma temprana los contextos donde el niño se desenvuelve (escuela, familia y comunidad), contando con un equipo multidisciplinar. En esta línea, las modalidades de intervención que han mostrado ser más efectivas son las medicaciones estimulantes, las intervenciones psicosociales y los tratamientos que combinan ambas opciones terapéuticas. El estimulante más utilizado para el TDAH, el metilfenidato, es el fármaco más prescrito en psiquiatría infantil y se ha constatado reiteradamente su efectividad. Pero se debe administrar con cautela porque presenta limitaciones que en ocasiones no compensan su administración, como sus efectos indeseados; el desconocimiento sobre sus efectos a largo plazo; y los escasos estudios sobre su eficacia y seguridad en niños preescolares. Estos hallazgos nos instan a considerar las intervenciones psicosociales, que son también una buena opción terapéutica. Las intervenciones psicosociales validadas empíricamente son el entrenamiento a padres y a maestros en el manejo del trastorno, y en menor medida el entrenamiento en habilidades socio-emocionales al propio niño. La finalidad de estas terapias es que paralelamente o tras la formación, se implementen intervenciones conductuales, cognitivo-conductuales, escolares y socio-emocionales en los contextos naturales del niño. Sin embargo, a pesar de la eficacia de estas modalidades de intervención de forma aislada, se han mostrado mejoras superiores con los tratamientos combinados o multimodales, que cubren un amplio abanico de dificultades y planos de funcionamiento, permitiendo en ocasiones reducir la dosis de medicación con un mantenimiento de los efectos positivos. Pero desafortunadamente, aún se observa una relativa carencia de estudios que incluyan tratamientos combinados para el TDAH infantil, al menos en España. Y en el mejor de los casos, las intervenciones han sido muy breves e intensivas. Asimismo, no se han publicado estudios sobre la eficacia de estas intervenciones para mejorar variables como el clima escolar y familiar de estos niños. Precisamente, el objetivo de este proyecto es analizar la eficacia relativa y diferencial de un tratamiento combinado (medicación estimulante+entrenamiento a padres y maestros) versus farmacológico, durante un curso escolar, para mejorar diversas variables relacionadas con el niño hiperactivo, sus maestros y sus padres (síntomas, rendimiento académico, clima escolar y familiar, autoeficacia percibida y conocimientos sobre TDAH).
ADHD is a neuro-developmental disorder of attention, impulsivity and activity of a chronic nature, affecting 4% of the population, frequently associated with other disorders such as behavioral problems and learning disabilities. Today, there is empirical evidence on genetic and biological origin, although its clinical course and prognosis are greatly influenced by environmental factors. Hence, an adequate management of the process of assessment and intervention for this disorder should contemplate early contexts where the child develops (school, family and community), with a multidisciplinary team. In this stratum, the interventions that have proven most effective are stimulant medications, psychosocial interventions and treatments that combine both options. The stimulant used for ADHD, methylphenidate, is the most prescribed drug in child psychiatry and has been found repeatedly to be effective. But it should be administered with caution, because it has limitations, like its side effects, the lack of long-term effects, and the few studies on efficacy and safety in preschool children. These findings urge us to consider psychosocial interventions, which are also a good option. Empirically valid psychosocial interventions are parent training and teachers in the management of the disorder, and less training in socio-emotional skills the child itself. The purpose of these therapies is that, - parallel or after the training -, behavioral, cognitive-behavioral, and socio-emotional interventions would be implemented in the child's natural settings. However, despite the effectiveness of these modalities of intervention in isolation, greater improvement has been shown with combined or multimodal treatments covering a wide range of problems, allowing sometimes to reduce the dose of medication, with a maintenance of positive effects. But unfortunately there is still a relative lack of studies involving combined treatments for childhood ADHD, at least in Spain. And in most cases, interventions have been very brief and intensive. Also, there are no published studies on the effectiveness of these interventions to improve variables such as school and family environment of these children. The precise purpose of this project is to analyze the relative and differential efficacy of combined treatment (stimulant medication + training for parents and teachers) versus drug, during a school year, in order to improve various variables related to the hyperactive child, their teachers and their parents (symptoms, academic performance, school and family evironment, self-efficacy and knowledge about ADHD).

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Ko, E. Soon. "Product Matching through Multimodal Image and Text Combined Similarity Matching". Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-301306.

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Product matching in e-commerce is an area that faces more and more challenges with growth in the e-commerce marketplace as well as variation in the quality of data available online for each product. Product matching for e-commerce provides competitive possibilities for vendors and flexibility for customers by identifying identical products from different sources. Traditional methods in product matching are often conducted through rule-based methods and methods tackling the issue through machine learning usually do so through unimodal systems. Moreover, existing methods would tackle the issue through product identifiers which are not always unified for each product. This thesis provides multimodal approaches through product name, description, and image to the problem area of product matching that outperforms unimodal approaches. Three multimodal approaches were taken, one unsupervised and two supervised. The unsupervised approach uses straight-forward embedding space to nearest neighbor search that provides better results than unimodal approaches. One of the supervised multimodal approaches uses Siamese network on the embedding space which outperforms the unsupervised multi- modal approach. Finally, the last supervised approach instead tackles the issue by exploiting distance differences in each modality through logistic regression and a decision system that provided the best results.
Produktmatchning inom e-handel är ett område som möter fler och fler utmaningar med hänsyn till den tillväxt som e-handelsmarknaden undergått och fortfarande undergår samt variation i kvaliteten på den data som finns tillgänglig online för varje produkt. Produktmatchning inom e-handel är ett område som ger konkurrenskraftiga möjligheter för leverantörer och flexibilitet för kunder genom att identifiera identiska produkter från olika källor. Traditionella metoder för produktmatchning genomfördes oftast genom regelbaserade metoder och metoder som utnyttjar maskininlärning gör det vanligtvis genom unimodala system. Dessutom utnyttjar mestadels av befintliga metoder produktidentifierare som inte alltid är enhetliga för varje produkt mellan olika källor. Denna studie ger istället förslag till multimodala tillvägagångssätt som istället använder sig av produktnamn, produktbeskrivning och produktbild för produktmatchnings-problem vilket ger bättre resultat än unimodala metoder. Tre multimodala tillvägagångssätt togs, en unsupervised och två supervised. Den unsupervised metoden använder embeddings vektorerna rakt av för att göra en nearest neighborsökning vilket gav bättre resultat än unimodala tillvägagångssätt. Ena supervised multimodal tillvägagångssätten använder siamesiska nätverk på embedding utrymmet vilket gav resultat som överträffade den unsupervised multimodala tillvägagångssättet. Slutligen tar den sista supervised metoden istället avståndsskillnader i varje modalitet genom logistisk regression och ett beslutssystem som gav bästa resultaten.

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Zhang, Zhiqing. "Carriers' liabilities in sea/land multimodal transport". Thesis, University of Bristol, 1995. http://hdl.handle.net/1983/e6ebb0c4-8e4c-49c2-a5d6-ee74379ae3b0.

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Cullen, Ralph Haywood. "Multimodal Multitasking: The Combined Effects of Postural and Cognitive Demands on Overall Workload". Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/49696.

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Workers are challenged by the increasingly complex multitasking environments they experience. To interact effectively with these environments, they must avoid overload. When workers get overloaded (when their mental demands exceed the resource capacity) quality drops, performance degrades, and safety suffers. What is largely unknown, however, is whether these results translate to postural tasks. Postural stability exhibits an entirely different set of challenges: injury, the danger of slips and falls, and risks associated with aging workers or those who have mental or physical challenges. An assembly line worker, for example, must assume different postures, interact with the product in some way, and react to visual and auditory alarms. Mistakes could be dangerous. It is clearly important, then, to understand the interactive effects of mental and postural workload. The goal of this research was to quantify the effects of mental and postural demands on overall workload. To accomplish this, we implemented three studies that were designed to capture the synergistic effects of different task types on overall workload and compare different types of workload measures against each other to help further design research in the area. We designed a dual-task mental/postural protocol to test the differential effects of a series of cognitive demands found in dual-task postural studied. The results of the first study depict a clear picture: the addition of an auditory task to unstable seating decreases postural sway. Based solely on this result, it might be concluded that workload did not increase. Using the same protocol while measuring mental workload however, we found that workload did in fact increase both subjectively and objectively, even when similar postural benefit was found. Even as performance seemed to improve, the participant moved nearer to possible overload and performance decrement (a condition we did not induce in this research). Based on the differences found between the different measures, we believe the importance of measuring overall workload as well as individual task performance in cognitive/postural dual-task research is very high.
Ph. D.

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Lee, Dong-Un. "Application of combined non-thermal treatments for the processing of liquid whole egg". [S.l.] : [s.n.], 2002. http://edocs.tu-berlin.de/diss/2002/lee_dongun.pdf.

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Maiorana, Maria Valeria. "Analysis of the effects of metformin administered alone or in combined treatments in colorectal cancer". Thesis, Open University, 2017. http://oro.open.ac.uk/49296/.

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The aim of this project was to investigate the anticancer activity of the anti-diabetic drug metformin, individually or combined in various settings with chemotherapy, on in vitro models of colorectal cancer (CRC). I found that metformin reduced cell proliferation by inducing cell cycle arrest in the G0/G1 phase, but did not lead to cell death. The anti-proliferative action of metformin resulted mediated by the inactivation of the mTOR pathway and of IGF1R protein. However, the drug only transiently arrested cell growth, since its effects were reversed after drug removal. When I combined the biguanide with the chemotherapy drugs commonly used to treat CRC I observed different responses in the cell lines analysed that reflected their genetic background and their different sensitivities to both the biguanide and chemotherapy. I found that metformin added before chemotherapy drugs antagonised their effects in the majority of the treatments. On the contrary, its administration after long chemotherapeutic treatments significantly reduced the cell viability. I noted that metformin better inhibits cell proliferation in cell lines with rapid growth. I have also assessed the dual treatment combination of metformin with different drugs that target specific genes or proteins (targeted therapies), focusing on BRAF-mutant cell lines. For most of the tested treatments the simultaneous administration of metformin and target drugs gave no advantages over the single drugs, and often resulted in antagonism. Overall, our results show that although further investigations are still needed to elucidate the results of the treaments including metformin, these data suggest that caution should be used in administering chemotherapy to indviduals taking metformin.

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Mark, Clarisse Ildikó. "Image-guided radiotherapy using 2D and 3D ultrasound combined with Monte Carlo dose calculations in prostate treatments". Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98761.

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Two ultrasound systems were studied to investigate the effects of positional and volumetric prostate variations on dosimetry over the course of external radiation therapy. A 2D system, currently used at the Montreal General Hospital for patient repositioning, was compared to a 3D system invented recently. Prostate variations were quantified from ultrasound images acquired daily during a 2003 clinical study. A method was devised to introduce ultrasound information in a Monte Carlo Treatment Planning System previously developed at McGill. Patient repositioning was evaluated for both systems using dose-volume histograms of Voxel Monte Carlo dose calculation. Repositioning with the 3D system, neglecting volume changes, was found to bring the target dose to within 1 % of the planned dose, rather than the 12 % of the clinical 2D system. However, when considering the varying 3D volumes, the dose could only be corrected to within 7 %. These results indicate that the 3D system provides not only a more accurate assessment of prostate displacements, but also volumetric information that significantly affects the dosimetry.

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Plattenburg, Joseph Allan. "Development of Refined Analytical Vibration Models for Plates and Shells with Combined Active and Passive Damping Treatments". The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460578500.

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Clemente, Bellido Miriam. "Contributions to Neuropsychotherapy of the Combined Use of Neuroimaging and Virtual Exposure for Assessment in Psychological Treatments". Doctoral thesis, Universitat Politècnica de València, 2014. http://hdl.handle.net/10251/37234.

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Neuropsychotherapy is a new philosophy in the treatment of mental disorders that bases its principles in the application of the information we have about the brain activations and brain functioning to adjust the therapy to them, in order to center the process in how the brain evolves to its normal activations. New tools in the field of neuroimaging have helped in this process, providing accurate and detailed information about how the particular brain of each patient works. Between the many neuroimaging techniques available nowadays, the functional magnetic resonance (fMRI) stands out by its high spatial resolution, which allows a better knowledge of which brain area is activated before each stimulus or while performing each activity. The disadvantages this technique presents in terms of size of the scanner and restriction of movements give light to another technique, more suitable in certain domains: the electroencephalography (EEG), which provides a greater freedom of movement and higher temporal resolution. For the purposes of this PhD Thesis, both techniques will be compared, in order to find which one better suits our interests. For doing so, another factor will be taken into account. Due to the limitations the neuroimaging techniques have in terms of presentation of the stimuli, we are not able to expose the subject to certain kinds of real life situations. There is where the virtual reality (VR) enters the scene. With VR we are able to move the subject to a virtual world where any kind of stimulus is possible. In the case of neuropsychotherapy, it will allow the exposition of the patient to a situation related to his disorder, in a safer and more controlled environment. In fact, virtual reality has been widely used for the treatment of psychological disorders; but, until now, it has not been applied during the assessment of the disease. For the aims of this Thesis, virtual environments will be used for the assessment of subjects before and after undergoing a psychological treatment for a specific disorder, using neuroimaging techniques to find useful information that could help during the therapeutic process. As an example of disorder, the phobia to small animals (spiders and cockroaches) has been chosen, although the conclusions of this study could be extended to other kinds of psychological disorders. Before being able to assure that the brain activations obtained are related to the disorder and not to other issues, it is needed to measure the sense of presence the subjects felt during the virtual experience. This is why before the assessment of a psychological disorder, a study of the sense of presence in a virtual environment was introduced. This study also helped in the decision of which neuroimaging technique apply in the second part of the Thesis. EEG and fMRI were used for the measure of presence in the same virtual environments, and the results in terms of brain activations were compared. Presence was also measured by means of questionnaires, the traditional subjective way of measuring it. As a result of this study it is expected to check if VR could effectively stimulate presence and which neuroimaging technique is more appropriate for the targets of this Thesis. To sum up, the initial hypotheses of this Thesis are that: 1- The new neuroimaging techniques can provide of useful information to use during neuropsychotherapy. 2- Virtual reality would help in the assessment of the disorder, improving the accuracy in the way the subjects are exposed to the stimuli. 3- The environments used would be immersive enough so the patient will feel present in them and feel them as real. For fulfilling these objectives, each of the two courses of work (study of presence and assessment of a mental disorder) was divided in two parts. In total, four studies were developed: 1- Study of the sense of presence in a virtual environment using fMRI: the aim of this part of the Thesis was to check if the environments were able to stimulate the sense of presence, correlating the results with those given to questionnaires. 2- Study of the sense of presence in a virtual environment using EEG: the aim here was to compare the brain activations obtained with EEG with those from the previous study, and if the responses of the questionnaires were equivalent despite being in a less intrusive scanner. As a result of these two studies, it was decided that the environments were immersive enough to induce the sense of presence, and that the best neuroimaging technique for the next part of the Thesis was the fMRI, due to the higher spatial resolution it brought. 3- Assessment of a psychological disorder, pre-treatment: once decided the study will continue with fMRI, the areas related to a specific disorder (small animals¿ phobia) were studied using VR as stimulus. Until now, the assessment has been done using real animals as stimuli but not using VR, which here is hypothesized to allow a better approach to the phobic experience than the view of photographs or videos of real animals. 4- Assessment of the state of subjects with a psychological disorder, post-treatment: once the patients had underwent a treatment to cure the disorder, they were assessed again to check if the brain areas related to the phobia stopped being activated after it. As a result of this second part of the Thesis, the brain areas related to the phobia (that stopped being activated after the treatment) were obtained, and this information is hoped to be useful in future neuropsychotherapeutic works, for the better adjustment of the disorder. In conclusion, this PhD Thesis studies the advantages that the new neuroimaging techniques and virtual reality could bring to the study of neuropsychotherapy.
Clemente Bellido, M. (2014). Contributions to Neuropsychotherapy of the Combined Use of Neuroimaging and Virtual Exposure for Assessment in Psychological Treatments [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/37234
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Rodríguez, Navarro Sarai. "New and combined treatments for cirrhosis and portal hypertension: effects on hemodynamics and hepatic fibrosis in experimental animal models". Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/390964.

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La cirrosi, la causa més freqüent d’hipertensió portal (HTP) en els països occidentals, és considerada una malaltia amb múltiples fases, que evoluciona des d'etapes inicials asimptomàtiques a un estat de cirrosi descompensada amb diverses manifestacions clíniques, les quals representen la principal causa de mort i de trasplantament hepàtic a tot el món. Per tant, caldria adaptar les diferents teràpies per a la cirrosi a cadascuna de les fases de la malaltia. Malgrat els avenços realitzats en les últimes dècades per entendre millor la fisiopatologia de la HTP i poder desenvolupar noves estratègies farmacològiques, fins al moment, els beta-bloquejants no selectius (BBNS) continuen sent la base del tractament dels pacients cirròtics amb HTP per a reduir la pressió portal (PP) i prevenir l'hemorràgia per varius. Aquesta tesi doctoral se centra en l'estudi de noves estratègies terapèutiques per al tractament de la cirrosi hepàtica en diferents etapes de la malaltia. Concretament, hem provat dos nous potencials fàrmacs orals, sols o en combinació amb d’altres fàrmacs convencionals, per veure la seva eficàcia en diversos models d’experimentació animal d’HTP: el model de lligadura de la vena porta (LVP), el de lligadura del conducte biliar (LCB), i el model d’intoxicació per tetraclorur de carboni (CCl4). Tres estudis conformen aquesta tesi. En el primer estudi, es va avaluar la utilitat de la droxidopa, un fàrmac pro-adrenèrgic que ja s'utilitza en humans per a altres indicacions, en el tractament de les alteracions hemodinàmiques i renals associades a la cirrosi hepàtica; en el segon estudi, es van testar combinacions de droxidopa amb d’altres fàrmacs que disminueixen la PP (BBNS o estatines), per tal d'intentar aconseguir un efecte sinèrgic i, en el tercer estudi, es va dur a terme una comparació, pel que fa a la reducció de la PP i la toxicitat, de l’efecte de les estatines convencionals (simvastatina, atorvastatina) amb el NCX 6560, una atorvastatina alliberadora d'òxid nítric (ON). La droxidopa va produir un efecte diürètic i natriürètic destacat, i va millorar les alteracions sistèmiques i hemodinàmiques de les rates amb HTP mitjançant l'augment de la pressió arterial mitjana i la resistència de l’artèria mesentèrica superior conjuntament amb una reducció del flux sanguini en l'artèria mesentèrica superior. El tractament crònic amb propranolol més droxidopa va reduir la PP, tot mantenint l'increment en la diüresi i la natriüresi de la droxidopa. Ni la combinació aguda de carvedilol més droxidopa, ni la combinació amb atorvastatina, van aconseguir un efecte sinèrgic. La comparació entre les diferents estatines va mostrar un major efecte tòxic d'aquests fàrmacs en un model que reprodueix una funció hepàtica deteriorada i colèstasi (especialment amb el tractament amb simvastatina), i el NCX 6560 va millorar la HTP de manera similar a l'atorvastatina en dos models cirròtics (LCB i CCl4), però amb menor toxicitat i un millor perfil vasoprotector intrahepàtic. En conjunt, els resultats d’aquesta tesi apunten a un potencial ús terapèutic de la droxidopa per al tractament dels pacients cirròtics amb ascites refractària i síndrome hepatorenal tipus 2, fins i tot en aquells pacients que estan en tractament amb propranolol, i a un ús més segur del NCX 6560 en el potencial tractament a llarg termini de la HTP amb estatines.
Cirrhosis, the most frequent cause of portal hypertension (PHT) in Western countries, is considered a multistage disease progressing from asymptomatic initial stages to decompensated cirrhosis with multiple clinical manifestations, which are a leading cause of death and liver transplantation worldwide. Therefore, therapies in liver cirrhosis should be adapted to each stage of the disease. Although many advances has been made in the last decades to understand the pathophysiology of PHT and develop new pharmacological approaches, up to now, non-selective beta-blockers (NSBB) still remain the mainstay of treatment in cirrhotic patient with PHT in order to reduce portal pressure (PP) and prevent variceal bleeding. The present doctoral thesis focuses on the study of new therapeutic strategies for the management of liver cirrhosis at different stages of the disease. In particular, two potential oral new drugs were tested, alone or in combination with other conventional drugs, to see their efficacy in several experimental animal models of PHT: the portal vein ligation (PVL), the bile duct ligation (BDL), and the carbon tetrachloride (CCl4) models. Three studies constitute this thesis. In the first study, the pro-adrenergic drug droxidopa, already used in humans for other indications, was evaluated for the management of the hemodynamic and renal alterations associated with liver cirrhosis; in the second study, combinations of droxidopa with other PP-lowering drugs (NSBB or statins) were performed in order to achieve a synergistic effect and, in the third study, a comparison of conventional statins (simvastatin, atorvastatin) with the nitric oxide (NO)-donating atorvastatin NCX 6560, in terms of PP lowering effect and toxicity, was also carried out. Droxidopa produced a marked diuretic and natriuretic effect, and improved the systemic and hemodynamic alterations of portal hypertensive rats by increasing mean arterial pressure and superior mesenteric artery resistance and by reducing superior mesenteric artery blood flow. A chronic treatment with propranolol plus droxidopa reduced PP, maintaining the increase in diuresis and natriuresis caused by droxidopa. Neither the acute combination of carvedilol plus droxidopa nor the combination with atorvastatin achieved a synergistic effect. The comparison among statins showed a magnified toxic effect of these drugs in a model that mimics a deteriorated liver function and cholestasis (especially with simvastatin treatment), and NCX 6560 improved PHT similarly to atorvastatin in two cirrhotic models (BDL and CCl4), but with less toxicity and a better intrahepatic vasoprotective profile. Altogether, the results presented in this thesis point to a potential therapeutic use of droxidopa in the management of cirrhotic patients with refractory ascites and type-2 hepatorenal syndrome, even in those patients on propranolol therapy, and to a safer use of NCX 6560 in the potential long-term statin treatment of PHT.

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Libri sul tema "Combined or multimodal treatments"

Butorac, Marc, James Bonneson, Kristine Connolly, Paul Ryus, Bastian Schroeder, Kristine Williams, Zhenyu Wang, Seckin Ozkul e Jerome Gluck. Assessing Interactions Between Access Management Treatments and Multimodal Users. Washington, D.C.: Transportation Research Board, 2018. http://dx.doi.org/10.17226/25344.

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C, Liebman Marcia, e Camp-Sorrell Dawn, a cura di. Multimodal therapy in oncology nursing. St. Louis: Mosby, 1996.

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Pfiffner, Linda J., e Lauren M. Haack. Nonpharmacologic Treatments for Childhood Attention-Deficit/Hyperactivity Disorder and Their Combination with Medication. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780199342211.003.0003.

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Of the nonpharmacological treatments for childhood attention-deficit/hyperactivity disorder (ADHD), behavioral interventions have the largest evidence base. Current behavioral interventions include behavioral parent training, behavioral classroom management, child skills training, behavioral multicomponent interventions, and multimodal treatment, which combines behavioral interventions and medication. This updated review of studies reveals significant behavioral treatment effects from randomized controlled trials on a wide range of child outcomes including ADHD and oppositional defiant disorder symptoms as well as areas of functional impairment such as homework, organizational, and social behaviors. Combined behavioral and medication treatments appear to reduce the needed dose or intensity of each intervention.

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Frank, Newman Cory, a cura di. El trastorno bipolar: Una aproximación desde la terapia cognitiva. Barcelona: Paidós, 2005.

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Cory F., Ph.D. Newman, Noreen Reilly-harrington, Laszlo M. D. Gyulai, Aaron T. Beck e Robert L. Leahy. El Trastorno Bipolar / Bipolar Disorder: Una aproximacion desde la terapia cognitiva/A Cognitive Therapy Approach (Psicologia, Psiquiatria, Psicoterapia). Ediciones Paidos Iberica, 2005.

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Hansen, Tom G. Acute paediatric pain management. A cura di Jonathan G. Hardman e Neil S. Morton. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0073.

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Paediatric pain management has made great strides in the past few decades in the understanding of developmental neurobiology, developmental pharmacology, the use of analgesics in children, the use of regional techniques in children, and of the psychological needs of children in pain. The consequences of a painful experience on the young nervous system are so significant that long-term effects can occur, resulting in behavioural changes and a lowered pain threshold for months after a painful event. Accurate assessment of pain in different age groups and the effective treatment of postoperative pain are constantly being refined, with newer drugs being used alone and in combination with other drugs, and continue to be explored. Systemic opioids, paracetamol, non-steroidal anti-inflammatories, and regional anaesthesia alone or combined with additives are currently used to provide effective postoperative analgesia. These modalities are often best utilized when combined as a multimodal approach to treat acute pain in the perioperative setting. The safe and effective management of pain in children includes the prevention, recognition, and assessment of pain; early and individualized treatment; and evaluation of the efficacy of treatment. This chapter discusses selected topics in paediatric acute pain management, with more specific emphasis placed on pharmacology and regional anaesthesia in the treatment of acute postoperative pain management.

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(Foreword), L. W. Brady, H. P. Heilmann (Foreword), M. Molls (Foreword), J. M. Brown (Editor), M. P. Mehta (Editor) e C. Nieder (Editor), a cura di. Multimodal Concepts for Integration of Cytotoxic Drugs (Medical Radiology / Radiation Oncology). Springer, 2006.

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(Editor), Morgan T. Sammons, e Norman B. Schmidt (Editor), a cura di. Combined Treatments for Mental Disorders: A Guide to Psychological and Pharmacological Interventions. American Psychological Association (APA), 2001.

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LaFrance, W. Curt, e Laura H. Goldstein. Evidence-Based Treatments. A cura di Barbara A. Dworetzky e Gaston C. Baslet. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190265045.003.0014.

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Psychogenic nonepileptic seizures (PNES) have been in the medical literature for centuries. However, treatments were limited, being based on uncontrolled data, until the past decade. Treatment advances published since 2010 have included pilot controlled trials using psychotherapies, psychoeducational approaches, medications, and combined pharmacological and psychotherapeutic approaches that provide new treatment options for patients with PNES. This chapter describes these controlled trials in detail. It also covers studies of treatments for other functional neurological disorders including PNES. One conclusion from this review is that future studies still need to improve on as-yet limited sample sizes and provide insights into predictors of treatment outcome so that rational decisions can be made about which treatments offer the best outcome and who is likely to best respond to which treatment.

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Tolin, David F., e Blaise L. Worden. Combining Pharmacotherapy and Psychological Treatments for OCD. A cura di Gail Steketee. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195376210.013.0081.

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This chapter reviews the outcome literature on the efficacy of combined pharmacotherapy and cognitive-behavioral therapy (CBT) for obsessive compulsive disorder (OCD). By far, most research on combinations of CBT and pharmacotherapy for OCD has examined antidepressant medications, particularly those in the serotonin reuptake inhibitor (SRI) class. Quantitative review of randomized studies in which treatments were combined simultaneously indicated that combined therapy shows a small but significant advantage over exposure and response prevention (ERP) monotherapy, and a moderate advantage over pharmacologic (antidepressant) monotherapy. Studies of sequential treatment combination, in which CBT was added after a trial of antidepressant medication, suggest a significant incremental benefit of CBT, including for patients who show minimal response to antidepressant medication alone. The chapter concludes by discussing new pharmacologic possibilities for combined therapy, such as the use of D-cycloserine (DCS).

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Petrovitch, Alexander, Merten Hommann, Dieter Hörsch, Patricia Grau, Sándor Kónya, Arnold Schneider e Richard P. Baum. "New Approaches: Combined Local and Multimodal Strategies in the Treatment of Complex Neuroendocrine Liver Metastases". In Therapeutic Nuclear Medicine, 405–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/174_2012_783.

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Cannarozzo, Giovanni, Steven Paul Nisticò, Keyvan Nouri e Mario Sannino. "Combined Laser Treatments". In Atlas of Lasers and Lights in Dermatology, 225–35. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-31232-9_25.

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Sánchez, C., E. Altmann-Canestri, U. Tropper, E. Tkach e D. Clar. "Ambulatory Phlebectomy and Combined Treatments". In Phlebology ’95, 33. London: Springer London, 1995. http://dx.doi.org/10.1007/978-1-4471-3095-6_15.

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Yan, Yiyi. "Combined Immunotherapy with Conventional Cancer Treatments". In The Basics of Cancer Immunotherapy, 115–23. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70622-1_7.

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Li, Zi Cai. "Singularities and Treatments". In Combined Methods for Elliptic Equations with Singularities, Interfaces and Infinities, 49–97. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4613-3338-8_2.

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Hildebrand, J. "Combined Modality Treatments in Malignant Supratentorial Gliomas". In Tumours of the Brain, 209–13. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-3437-4_13.

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Forsberg, Daniel, Yogesh Rathi, Sylvain Bouix, Demian Wassermann, Hans Knutsson e Carl-Fredrik Westin. "Improving Registration Using Multi-channel Diffeomorphic Demons Combined with Certainty Maps". In Multimodal Brain Image Analysis, 19–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-24446-9_3.

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Fabris, Rolando, Christopher W. K. Chow e Mary Drikas. "Combined Treatments for Enhanced Reduction of Trihalomethane Precursors". In ACS Symposium Series, 214–26. Washington, DC: American Chemical Society, 2008. http://dx.doi.org/10.1021/bk-2008-0995.ch015.

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Zanoni, Andrea, Simone Giacopuzzi, Elio Treppiedi, Jacopo Weindelmayer e Giovanni de Manzoni. "Long-Term Results with Surgery Alone and Multimodal Treatments". In Adenocarcinoma of the Esophagogastric Junction, 185–91. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-28776-8_19.

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Coelho, J., e P. Marteau. "Mild to moderate ulcerative colitis: sequential and combined treatments". In Intestinal Disorders, 103–6. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-1-4020-9591-7_12.

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Atti di convegni sul tema "Combined or multimodal treatments"

Smith, P. S., C. C. Clement e A. Mendoza Rojas. "Combined Scale Removal and Scale Inhibition Treatments". In International Symposium on Oilfield Scale. Society of Petroleum Engineers, 2000. http://dx.doi.org/10.2118/60222-ms.

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Calvo, C., G. A. Silva-Castro, I. Uad, M. Manzanera, C. Perucha, J. Laguna e J. Gónzalez-López. "Biostimulation combined treatments for remediation of diesel contaminated soil". In ENVIRONMENTAL TOXICOLOGY 2010. Southampton, UK: WIT Press, 2010. http://dx.doi.org/10.2495/etox100111.

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Spigulis, Janis, Ilona Kuzmina, Vanesa Lukinsone, Mindaugas Tamosiunas, Ilze Oshina, Laura Ozolina, Anna Maslobojeva, Maris Kuzminskis, Deyan Ivanov e Ekaterina Borisova. "Towards combined multispectral, FLIM and Raman imaging for skin diagnostics". In Multimodal Biomedical Imaging XV, a cura di Fred S. Azar, Xavier Intes e Qianqian Fang. SPIE, 2020. http://dx.doi.org/10.1117/12.2559107.

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Attendu, Xavier, Paul R. Bloemen, Niels H. Kind, Daniel M. de Bruin, Dirk J. Faber, Caroline Boudoux e Ton G. van Leeuwen. "Combined optical coherence tomography and broadband single fiber reflectance spectroscopy". In Multimodal Biomedical Imaging XVI, a cura di Fred S. Azar, Xavier Intes e Qianqian Fang. SPIE, 2021. http://dx.doi.org/10.1117/12.2578129.

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Dupuis, G., J. Bouillot, A. Zaitoun, G. Caremi e G. Burrafato. "Combined Water/Sand Control Polymer Treatments in Offshore Gas Wells". In SPE EOR Conference at Oil and Gas West Asia. Society of Petroleum Engineers, 2016. http://dx.doi.org/10.2118/179825-ms.

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Strupler, Mathias, Martin Poinsinet de Sivry-Houle, Xavier Attendu, Caroline Boudoux, Nicolas Godbout, Camille Crunelle, Joanie Urbain, Chloe Turrell e Billie Maubois. "Towards combined optical coherence tomography and hyper-spectral imaging for gastrointestinal endoscopy". In Multimodal Biomedical Imaging XIII, a cura di Fred S. Azar e Xavier Intes. SPIE, 2018. http://dx.doi.org/10.1117/12.2288772.

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Zhou, Jingkai, e Qiong Liu. "A combined similarity measure for multimodal image registration". In 2015 IEEE International Conference on Imaging Systems and Techniques (IST). IEEE, 2015. http://dx.doi.org/10.1109/ist.2015.7294549.

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Zhou, Yonghan, e Shuo Tang. "Combined speckle variance optical coherence tomography and multiphoton microscopy for in vivo chick CAM imaging". In Multimodal Biomedical Imaging XIV, a cura di Fred S. Azar, Xavier Intes e Qianqian Fang. SPIE, 2019. http://dx.doi.org/10.1117/12.2510296.

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Katsakioris, Miltiadis Marios, Helen Hastie, Ioannis Konstas e Atanas Laskov. "Corpus of Multimodal Interaction for Collaborative Planning". In Proceedings of the Combined Workshop on Spatial Language Understanding (. Stroudsburg, PA, USA: Association for Computational Linguistics, 2019. http://dx.doi.org/10.18653/v1/w19-1601.

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Fujimoto, Emily, e Matthew Turk. "Non-Visual Navigation Using Combined Audio Music and Haptic Cues". In ICMI '14: INTERNATIONAL CONFERENCE ON MULTIMODAL INTERACTION. New York, NY, USA: ACM, 2014. http://dx.doi.org/10.1145/2663204.2663243.

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Chen, Hongxi, Kenan Wu, Qinzuo Dong, Fan Liu, Xiuanwu Yue, Chunlin Xia, Yuanfeng Wang, Zeqin Ren e Rong Zhao. Acupuncture and moxibustion combined with various external treatments of traditional Chinese medicine to prevent and treat primary osteoporosis： A systematic review and Network Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, aprile 2021. http://dx.doi.org/10.37766/inplasy2021.4.0036.

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Kodupuganti, Swapneel R., Sonu Mathew e Srinivas S. Pulugurtha. Modeling Operational Performance of Urban Roads with Heterogeneous Traffic Conditions. Mineta Transportation Institute, gennaio 2021. http://dx.doi.org/10.31979/mti.2021.1802.

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The rapid growth in population and related demand for travel during the past few decades has had a catalytic effect on traffic congestion, air quality, and safety in many urban areas. Transportation managers and planners have planned for new facilities to cater to the needs of users of alternative modes of transportation (e.g., public transportation, walking, and bicycling) over the next decade. However, there are no widely accepted methods, nor there is enough evidence to justify whether such plans are instrumental in improving mobility of the transportation system. Therefore, this project researches the operational performance of urban roads with heterogeneous traffic conditions to improve the mobility and reliability of people and goods. A 4-mile stretch of the Blue Line light rail transit (LRT) extension, which connects Old Concord Rd and the University of North Carolina at Charlotte’s main campus on N Tryon St in Charlotte, North Carolina, was considered for travel time reliability analysis. The influence of crosswalks, sidewalks, trails, greenways, on-street bicycle lanes, bus/LRT routes and stops/stations, and street network characteristics on travel time reliability were comprehensively considered from a multimodal perspective. Likewise, a 2.5-mile-long section of the Blue Line LRT extension, which connects University City Blvd and Mallard Creek Church Rd on N Tryon St in Charlotte, North Carolina, was considered for simulation-based operational analysis. Vissim traffic simulation software was used to compute and compare delay, queue length, and maximum queue length at nine intersections to evaluate the influence of vehicles, LRT, pedestrians, and bicyclists, individually and/or combined. The statistical significance of variations in travel time reliability were particularly less in the case of links on N Tryon St with the Blue Line LRT extension. However, a decrease in travel time reliability on some links was observed on the parallel route (I-85) and cross-streets. While a decrease in vehicle delay on northbound and southbound approaches of N Tryon St was observed in most cases after the LRT is in operation, the cross-streets of N Tryon St incurred a relatively higher increase in delay after the LRT is in operation. The current pedestrian and bicycling activity levels seemed insignificant to have an influence on vehicle delay at intersections. The methodological approaches from this research can be used to assess the performance of a transportation facility and identify remedial solutions from a multimodal perspective.

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Lumpkin, Shamsie, Isaac Parrish, Austin Terrell e Dwayne Accardo. Pain Control: Opioid vs. Nonopioid Analgesia During the Immediate Postoperative Period. University of Tennessee Health Science Center, luglio 2021. http://dx.doi.org/10.21007/con.dnp.2021.0008.

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Background Opioid analgesia has become the mainstay for acute pain management in the postoperative setting. However, the use of opioid medications comes with significant risks and side effects. Due to increasing numbers of prescriptions to those with chronic pain, opioid medications have become more expensive while becoming less effective due to the buildup of patient tolerance. The idea of opioid-free analgesic techniques has rarely been breached in many hospitals. Emerging research has shown that opioid-sparing approaches have resulted in lower reported pain scores across the board, as well as significant cost reductions to hospitals and insurance agencies. In addition to providing adequate pain relief, the predicted cost burden of an opioid-free or opioid-sparing approach is significantly less than traditional methods. Methods The following groups were considered in our inclusion criteria: those who speak the English language, all races and ethnicities, male or female, home medications, those who are at least 18 years of age and able to provide written informed consent, those undergoing inpatient or same-day surgical procedures. In addition, our scoping review includes the following exclusion criteria: those who are non-English speaking, those who are less than 18 years of age, those who are not undergoing surgical procedures while admitted, those who are unable to provide numeric pain score due to clinical status, those who are unable to provide written informed consent, and those who decline participation in the study. Data was extracted by one reviewer and verified by the remaining two group members. Extraction was divided as equally as possible among the 11 listed references. Discrepancies in data extraction were discussed between the article reviewer, project editor, and group leader. Results We identified nine primary sources addressing the use of ketamine as an alternative to opioid analgesia and post-operative pain control. Our findings indicate a positive correlation between perioperative ketamine administration and postoperative pain control. While this information provides insight on opioid-free analgesia, it also revealed the limited amount of research conducted in this area of practice. The strategies for several of the clinical trials limited ketamine administration to a small niche of patients. The included studies provided evidence for lower pain scores, reductions in opioid consumption, and better patient outcomes. Implications for Nursing Practice Based on the results of the studies’ randomized controlled trials and meta-analyses, the effects of ketamine are shown as an adequate analgesic alternative to opioids postoperatively. The cited resources showed that ketamine can be used as a sole agent, or combined effectively with reduced doses of opioids for multimodal therapy. There were noted limitations in some of the research articles. Not all of the cited studies were able to include definitive evidence of proper blinding techniques or randomization methods. Small sample sizes and the inclusion of specific patient populations identified within several of the studies can skew data in one direction or another; therefore, significant clinical results cannot be generalized to patient populations across the board.

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Prostate Cancer: Evidence Update for Clinicians. Patient-Centered Outcomes Research Institute (PCORI), settembre 2017. http://dx.doi.org/10.25302/eu2.2017.9.

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Given the evidence of high 5- and 10-year survivorship rates for localized prostate cancer, the effect of treatment on symptom-related quality of life is an important consideration for men choosing among available treatment options. Two PCORI-funded studies published in the March 21, 2017 issue of JAMA compare the impact of current treatments on symptom-related quality of life for men with localized prostate cancer. Quality of life scores refer to symptoms, how much men were bothered by symptoms, or a combination of the two. The studies looked at observed outcomes from a combined total of 3,600 men for periods of two and three years following treatment. This evidence offers information that can help patients make treatment decisions.

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