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Letteratura scientifica selezionata sul tema "Controlled and sustained release"

Autore: Grafiati

Pubblicato: 7 giugno 2025

Ultima modifica: 2 agosto 2025

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Articoli di riviste sul tema "Controlled and sustained release"

1

Gauthier, Serge, and Donna Amyot. "Sustained Release Antiparkinson Agents: Controlled Release Levodopa." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 19, S1 (1992): 153–55. http://dx.doi.org/10.1017/s0317167100041548.

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ABSTRACT:The rationale for sustained release oral levodopa preparations is to deliver levodopa in the areas of maximal intestinal absorption in a slow and predictable way, leading to stable plasma levodopa levels and brain dopamine levels, therefore resulting in a lengthened duration of action. Sinemet CR is the prototype of such preparations, with demonstrated efficacy in decreasing periods of akinesia in parkinsonian patients with mild to moderate motor fluctuations. Total doses of levodopa are raised 10 to 30% because of the lowered bioavailability; diphasic dyskinesias may increase at the

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2

Kumar, Deepak, ,. Archana, and Abadhesh Kumar Niranjan. "A Comprehensive Review on Sustained Release Matrix Drug Delivery System." Journal of Drug Delivery and Therapeutics 12, no. 4-S (2022): 249–53. http://dx.doi.org/10.22270/jddt.v12i4-s.5540.

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Formulations for sustained medication release are very useful in the treatment of chronic disorders. The oral route has selected matrix tablets as the most likely type of prolonged drug release. In order to generate therapeutic activity for a protracted duration, matrix tablets maintain a stable plasma drug concentration and sustain the rate of release of the drug throughout time. In preparations with a short half-life and high dosage frequency, extended-release is crucial. The matrix regulates how quickly the medication is released. Retardants such polyglycolic acid, polymethyl methacrylate,

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3

Kalyani Shelar, Gauri Mahajan, Nikita Pagare, Prachiti Sahane, and Sakshi Bhosale. "Review on Sustained Release Tablet." International Journal of Scientific Research in Science and Technology 11, no. 6 (2024): 698–708. https://doi.org/10.32628/ijsrst241161126.

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This review highlights the advantages of SR formulations, including reduced side effects, enhanced drug utilization, improved treatment efficacy, and better patient compliance. Key considerations for developing sustained release tablet involve the drug's physicochemical properties and biological factors, such as absorption and metabolism. Various formulation strategies, including diffusion-controlled, dissolution-controlled, and osmotic systems, are discussed alongside essential evaluation parameters like density, hardness, and in-vitro drug release profiles. The outlook for sustained release

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4

Addanki, Anusha, Ponnekanti Krishnaphanisri, Tiwari Ramanuj, Swapna L., Mabrur Hussain Md, and Siddhardha A. "A review of medicines with sustained release." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 221–33. https://doi.org/10.5281/zenodo.8036007.

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Sustained-release matrix tablets allow for continuous drug release while also optimizing a drug's biologic, pharmacokinetic, and pharmacodynamic properties for maximum therapeutic efficacy. The matrix regulates the rate at which the drug is released. Because it facilitates prolonged release, the major excipient in the formulation is a release retardant. The technology may promote patient compliance and efficiently treat chronic illnesses by decreasing the overall dosage and dosing schedule. The drug is supplied in this system via diffusion- and dissolution-controlled methods. The primary g

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5

Addanki Anusha, Krishnaphanisri Ponnekanti, Ramanuj Tiwari, L. Swapna, Md Mabrur Hussain, and A Siddhardha. "A review of medicines with sustained release." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 221–33. http://dx.doi.org/10.30574/wjbphs.2023.13.3.0141.

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Sustained-release matrix tablets allow for continuous drug release while also optimizing a drug's biologic, pharmacokinetic, and pharmacodynamic properties for maximum therapeutic efficacy. The matrix regulates the rate at which the drug is released. Because it facilitates prolonged release, the major excipient in the formulation is a release retardant. The technology may promote patient compliance and efficiently treat chronic illnesses by decreasing the overall dosage and dosing schedule. The drug is supplied in this system via diffusion- and dissolution-controlled methods. The primary goal

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6

KATO, Yasutomi, Hisakazu SUNADA, Yorinobu YONEZAWA, and Ryuzo ISHINO. "Sustained Release Mechanisms of Wax Matrix System for Controlled Release." CHEMICAL & PHARMACEUTICAL BULLETIN 42, no. 8 (1994): 1646–50. http://dx.doi.org/10.1248/cpb.42.1646.

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Khoder, Mouhamad, Henry Gbormoi, Ali Ryan, Ayman Karam, and Raid Alany. "Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads." Pharmaceutics 11, no. 2 (2019): 83. http://dx.doi.org/10.3390/pharmaceutics11020083.

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In this study, bovine serum albumin (BSA) and alginate (ALG) conjugates were synthesized by the Maillard reaction in order to evaluate their potential to develop controlled release drug delivery systems. The progress of the Maillard reaction was evidenced using ultraviolet (UV) absorbance, determination of BSA remaining free amino groups, and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). BSA-ALG conjugates possessed enhanced and tunable viscosity, foamability and foam stability. Foam generated from BSA-ALG conjugate solution was used to prepare floating gastroretentive

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Bodhankar, Shishupal S., and Mohini Sihare. "Formulation and Evaluation of Multiparticulate Pellet Systems for Antidiabetic and Antihypertensive Drugs: Application of Extrusion– Spheronization and Solution Layering Techniques." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–08. https://doi.org/10.25258/ijddt.15.2.10.

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The present study focuses on the development and comprehensive evaluation of sustained and controlled release multiparticulate pellet formulations for three therapeutic agents: Tolbutamide, Saxagliptin, and Verapamil. The primary objective was to enhance drug release profiles and patient compliance using extrusion–spheronization and solution layering techniques. Tolbutamide and Verapamil were formulated into matrix-based sustained release pellets using hydrophilic polymers (HPMC) and plasticizers (MCC), while Saxagliptin pellets were prepared via solution layering on nonpareil seeds with optio

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Bayer, Ilker S. "Controlled Drug Release from Nanoengineered Polysaccharides." Pharmaceutics 15, no. 5 (2023): 1364. http://dx.doi.org/10.3390/pharmaceutics15051364.

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Polysaccharides are naturally occurring complex molecules with exceptional physicochemical properties and bioactivities. They originate from plant, animal, and microbial-based resources and processes and can be chemically modified. The biocompatibility and biodegradability of polysaccharides enable their increased use in nanoscale synthesis and engineering for drug encapsulation and release. This review focuses on sustained drug release studies from nanoscale polysaccharides in the fields of nanotechnology and biomedical sciences. Particular emphasis is placed on drug release kinetics and rele

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Sadhu, Venkateswara Rao, Priyanka Bopparaju, and Padmalatha Kantamneni. "Bilayer tablet technology: A novel approach." GSC Biological and Pharmaceutical Sciences 7, no. 2 (2019): 022–28. https://doi.org/10.5281/zenodo.4286145.

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Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second lay

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Tesi sul tema "Controlled and sustained release"

1

Rodriguez, Lidia Betsabe. "Controlled Release System for Localized and Sustained Drug Delivery Applications." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1365107103.

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Khamanga, Sandile Maswazi Malungelo. "Formulation and assessment of verapamil sustained release tablets." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1018236.

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The oral route of drug administration is most extensively used due to the obvious ease of administration. Verapamil hydrochloride is a WHO listed phenylalkylarnine, L-type calcium channel antagonist that is mainly indicated for cardiovascular disorders such as angina pectoris, supraventricular tachycardia and hypertension. Due to its relatively short half-life of approximately 4.0 hours, the formulation of a sustained-release dosage form is useful to improve patient compliance and to achieve predictable and optimized therapeutic plasma concentrations. Direct compression and wet granulation wer

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Li, Anqi. "Injectable hydrogels for controlled and sustained local drug delivery." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASQ014.

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Les hydrogels injectables sont largement explorés en tant que réservoirs pour une administration locale de substances actives (SA) afin d'en augmenter la biodisponibilité et réduire la toxicité systémique. En oncologie, une telle approche peut être particulièrement pertinent par exemple dans le traitement de la carcinose péritonéale pour laquelle le protocole thérapeutique standard repose sur une chirurgie cytoréductive suivie de l'administration intrapéritonéale (IP) d'une thermo-chimiothérapie (HIPEC). Cependant, les SA administrés par voie intrapéritonéale ont un temps de résidence court en

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McLellan, Bradley John. "Development of an Intraruminal Controlled-Release Device." The University of Waikato, 2007. http://hdl.handle.net/10289/2527.

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Slow-release devices retained in the rumen, are a simple method for continuous administration of bioactives to ruminant animals. To satisfy regulatory requirements and avoid waste of bioactive due to under- or over-dosing, it is advantageous to have a constant and predictable release rate. Existing intraruminal controlled-release technologies cannot easily be adapted for different bioactives or rates of release and can be influenced by the variable physiological environment in the rumen. Some existing commercial products use the pressure generated by a hydrogen gas-producing cell to extrude

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Sachikonye, Tinotenda Chipo Victoria. "Development and assessment of minocycline sustained release capsule formulations." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1013127.

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The use of minocycline for the treatment of a broad range of systemic infections and for severe acne has been associated with vestibular side effects. The severity of side effects may lead to poor adherence to therapy by patients. The use of sustained release formulations of minocycline that display slow dissolution of minocycline following administration may be beneficial in reducing the incidence and severity of side effects. Therefore, sustained release capsule dosage forms containing 100 mg minocycline (base) were manufactured and assessed for use as sustained release oral dosage forms of

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Kao, Chen-Yu. "Developing a Minimally Invasive Sustained Release System for Glioma Therapy." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19757.

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Malignant brain tumor is one of the most lethal forms of cancers. In the United States alone, approximately 20,500 new cases of primary malignant brain and central nervous system tumors are expected to be diagnosed in 2007 with 12,740 deaths estimated. Treatment of malignant brain tumor remains a major challenge despite recent advance in surgery and other adjuvant therapies, such as chemotherapy. The failure of potential effective chemotherapeutics for brain tumor treatment is usually not due to the lack of potency of the drug, but rather can be attributed to lack of therapeutic strategies ca

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Yeh, Hsi-wei. "Investigation of Polymeric Composites for Controlled Drug Release." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4971.

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The Electrospray (ES) technique is a promising particle generation method for drug delivery due to its capabilities of producing monodisperse PLGA composite particles with unique configurations and high drug encapsulation efficiency. In the dissertation work, the coaxial dual capillary ES was used to generate drug-loaded core-shell PLGA particles to study the effects of particle filling materials, drug loading locations and particle shell thicknesses on the resultant in vitro release behaviors of the hydrophilic and/ or hydrophobic model drugs. Through release profile characterization of drug-

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Mohl, Silke. "The Development of a Sustained and Controlled Release Device for Pharmaceutical Proteins based on Lipid Implants." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-30092.

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Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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Wang, Qing. "STRATEGIES FOR SUSTAINED RELEASE OF SMALL HYDROPHILIC DRUGS FROM HYDROGEL BASED MATRICES." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515164088562922.

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Libri sul tema "Controlled and sustained release"

1

M, MacLeod Stuart, and Szefler S. J, eds. Childhood asthma and sustained release theophylline: International workshop, Whistler, Canada. Excerpta Medica, 1986.

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2

Fan, Liang-tseng, and Satish Kumar Singh. Controlled Release. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74507-2.

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J, Norris R., Wale Laurence, and Revlon Health Care Group, eds. Sustained release verapamil workshop. Medical News Tribune Group, 1985.

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4

Lee, Ping I., and William R. Good, eds. Controlled-Release Technology. American Chemical Society, 1987. http://dx.doi.org/10.1021/bk-1987-0348.

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Keen, Fiona Eleanor. Controlled release antioxidants. University of Birmingham, 1989.

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Kyodonieus, Agis F. Controlled Release Technologies. Routledge, 2022. https://doi.org/10.1201/9780429297724.

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Varadachari, Chandrika. Slow-release and controlled-release nitrogen fertilizers. Published by Indian Nitrogen Group, Society for Conservation of Nature in association with South Asian Nitrogen Centre, International Nitrogen Initiative, 2010.

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Purkiss, Ronald. Bioequivalence of sustained release theophylline formulations. Aston University. Department of Pharmaceutical Sciences, 1986.

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9

Dinh, Steven M., John D. DeNuzzio, and Ann R. Comfort, eds. Intelligent Materials for Controlled Release. American Chemical Society, 1999. http://dx.doi.org/10.1021/bk-1999-0728.

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M, Dinh Steven, DeNuzzio John D. 1959-, and Comfort Ann R. 1960-, eds. Intelligent materials for controlled release. American Chemical Society, 1999.

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Capitoli di libri sul tema "Controlled and sustained release"

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Sharma, Shivangi, Neeru Dabas, Deepa Sharma, Mohit Kumar, Sanjay Kumar Kataria, and Gautam Jaiswar. "Smart Materials for Sustained and Controlled Drug Release." In Smart Micro- and Nanomaterials for Pharmaceutical Applications. CRC Press, 2024. http://dx.doi.org/10.1201/9781003468431-12.

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Ganguly, Sayan, and Shlomo Margel. "General Overview of Controlled and Sustained Release Systems." In Handbook of Nutraceuticals. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-030-69677-1_22-1.

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Sharma, Kartikey, and Vandana Guleria. "Adoption of Smart Materials for Sustained and Controlled Drug Release." In Smart Micro- and Nanomaterials for Drug Delivery. CRC Press, 2024. http://dx.doi.org/10.1201/9781003468424-16.

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Toews, Parker M., and Jeffrey S. Bates. "Molecular Imprinted Hydrogels for the Controlled and Sustained Release of Hydrophilic Drug Therapy." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4402-7_8.

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Kumar, Amrish, Sunil K. Jain, Dinesh K. Mishra, and Rupesh Gautam. "Influence of Drug Properties and Routes of Drug Administration on Design of Sustained and Controlled Release Systems." In Novel Carrier Systems for Targeted and Controlled Drug Delivery. Springer Nature Singapore, 2024. https://doi.org/10.1007/978-981-97-4970-6_1.

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Nahler, Gerhard. "sustained release." In Dictionary of Pharmaceutical Medicine. Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_1374.

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Tadros, Tharwat. "Controlled Release." In Encyclopedia of Colloid and Interface Science. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-20665-8_56.

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Huynh, Cong Truc, and Doo Sung Lee. "Controlled Release." In Encyclopedia of Polymeric Nanomaterials. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-36199-9_314-1.

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Smith, Kelly L., and Scott M. Herbig. "Controlled Release." In Membrane Handbook. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3548-5_47.

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Altinkaya, Sacide Alsoy. "Controlled Release." In Encyclopedia of Membranes. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_1236.

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Atti di convegni sul tema "Controlled and sustained release"

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Viglione, Jennavieve F., and Ali Kiapour. "Controlled Release Transdermal Patch." In 2024 IEEE MIT Undergraduate Research Technology Conference (URTC). IEEE, 2024. https://doi.org/10.1109/urtc65039.2024.10937605.

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Li, Wenyan, and Luz M. Calle. "Controlled Release Microcapsules for Smart Coatings." In CORROSION 2007. NACE International, 2007. https://doi.org/10.5006/c2007-07228.

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Abstract Corrosion in service is a serious problem for most military operations. The cost of corrosion includes manpower, materials used to repair corrosion damage, equipment downtime, and reduced capacity due to corrosion damage. A considerable number of corrosion problems can be solved by coatings. However, even the best protective coatings can fail by allowing the slow diffusion of oxygen and moisture to the metal surface. Corrosion accelerates when a coating delaminates. Often, the problems start when microscopic nicks or pits on the surface develop during manufacturing or through wear and

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Makovik, I. N., A. V. Dunaev, E. U. Rafailov, and V. V. Dremin. "Controlled Photosensitizer-free Singlet Oxygen Release for Biomedical Applications." In 2024 International Conference Laser Optics (ICLO). IEEE, 2024. http://dx.doi.org/10.1109/iclo59702.2024.10624325.

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Starly, Binil, Shih-Feng Lan, and David Schmidtke. "Customized Release of Metronidazole From Composite Casted Rings of Poly-Caprolactone/Alginate for Periodontal Drug Delivery." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14177.

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Dental implants provide support for dental crowns and bridges by serving as abutments for the replacement of missing teeth. The objective of this study was to demonstrate a novel method of controlled localized delivery of antibacterial agents to an implant site using a custom fabricated ring. The study involved incorporating a model antibacterial agent (metronidazole) into custom designed Poly-ε-Caprolactone/Alginate (PCL/Alginate) composite rings to produce the intended controlled release profile. In vitro release studies indicate that pure (100%) alginate rings exhibited an expected burst re

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Wu, Juan, Aipeng Deng, Wei Jiang, Renbing Tian, Wei Jiang, and Yewen Shen. "Synthesis and characterization of pH-sensitive magnetic nanoparticles as drug carriers for sustained and controlled release of MTX." In 2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2016. http://dx.doi.org/10.1109/nano.2016.7751295.

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Banerjee, Rupak K., Robert J. Lutz, Keyvan Keyhani, Robert L. Dedrick, Brian King, and Michael Robinson. "Comparison of Drug Distribution Between Intravitreal Injection and a Controlled–Release Implant in a Rabbit Eye." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2235.

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Abstract Due to physiological barriers within the eye, which limit penetration of many drugs from the systemic circulation into the vitreous, the most common method of treating retinal disease is direct intravitreal injection. However, this common procedure may be inappropriate for a wide range of drugs as it may lead to highly variable concentrations potentially causing higher toxicity for tissues inside the eye and limiting therapeutic effect. A recent procedure is to use surgically implanted drug release device, called implant here, in the vitreous of the eye that allow controlled release o

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Spurr, N., D. Stanley, M. Usie, F. Debenedictis, D. Schneider, and A. Lawler. "Deepwater Application of Proppant Controlled Release Inhibitor Leads to Successful Well Production in Gulf of Mexico." In SPE International Conference and Exhibition on Formation Damage Control. SPE, 2024. http://dx.doi.org/10.2118/217845-ms.

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Abstract Designing and achieving a deep-water frac pack in a new field that delivers low drawdown/low skin and high PI's is always a challenge. Successful design work, planning and execution are all key parameters. With additional challenges of a suspected high asphaltene content crude oil with relatively low onset pressures (AOP), another challenge was posed, "Can you place a solid inhibitor during the completion phase that can prolong expensive remediation treatments, while maximizing value by adjusting the chemical release pressure?" A new solid, controlled release proppant like inhibitor w

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Giammancheri, M., G. Tassone, Gabriel Carpineta, et al. "Infused Scale-Inhibitor Proppant Ensures Sustained Production Assurance Strategy Against Scale Deposition in Multi-Fractured Wells." In SPE International Hydraulic Fracturing Technology Conference and Exhibition. SPE, 2023. http://dx.doi.org/10.2118/215716-ms.

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Abstract This paper describes the production assurance strategy adopted to resolve scaling deposition in hydraulically fractured wellbores by means of incorporating a ceramic proppant infused with a controlled release scale inhibitor in the primary completion. This chemical delivery system has been applied as an integral component in the offshore field development program and yielded positive results. Production assurance and scale inhibition chemicals are traditionally injected via a dedicated capillary in the production string, but this approach is often not very efficient or effective as a

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Li, Xinyan, and Dan Zhao. "Feedback Control of Self-Sustained Nonlinear Combustion Oscillations." In ASME Turbo Expo 2015: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/gt2015-42126.

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Detrimental combustion instability is unwanted in gas turbines, aeroengines and rocket motors. It is typically generated due to the dynamic coupling between unsteady heat release and acoustic pressure. To prevent the onset of combustion instability or dampen large-amplitude oscillations, the coupling must somehow be interrupted. In this work, we design and implement a sliding mode controller and observer to mitigate self-sustained combustion oscillations in an open-ended thermoacoustic system. An acoustically compact heat source is confined and modeled by using a modified form of King’s Law. C

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Alhajeri, Mubarak Muhammad, Jenn-Tai Liang, and Reza Barati Ghahfarokhi. "Polyelectrolyte Multilayered Nanoparticles as Nanocontainers for Enzyme Breakers During Hydraulic Fracturing Process." In SPE Annual Technical Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/205981-ms.

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Abstract In this study, Layer-by-Layer (LbL) assembled polyelectrolyte multilayered nanoparticles were developed as a technique for targeted and controlled release of enzyme breakers. Polyelectrolyte multilayers (PEMs) were assembled by means of alternate electrostatic adsorption of polyanions and polycations using colloidal structure of polyelectrolyte complexes (PECs) as LbL building blocks. High enzyme concentrations were introduced into polyethyleneimine (PEI), a positively charged polyelectrolyte solution, to form an electrostatic PECs with dextran sulfate (DS), a negatively charged polye

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Rapporti di organizzazioni sul tema "Controlled and sustained release"

1

Mukhtar, Hasan. Sustained Release Oral Nanoformulated Green Tea for Prostate Cancer. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada545577.

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Mukhtar, Hasan. Sustained Release Oral Nanoformulated Green Tea for Prostate Cancer Prevention. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada585226.

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Mukhtar, Hasan, Nihal Ahmad, Vaqar M. Adhami, and Naghma Khan. Sustained Release Oral Nanoformulated Green Tea for Prostate Cancer Prevention. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada589659.

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4

Chutimaworapan, Suchada, Chaiyo Chaichantippayuth, and Areerat Laopaksa. Formulation of pharmaceutical products of Garcinia mangostana Linn. extracts. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.32.

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Part I: The purpose of the investigation was to develop the extraction process that was simple, practical and giving high yield. The maceration of dried powder of Garcinia mangostana fruit husk with ethyl acetate gave yellow crystalline powder of mangostin. The yield was calculated as 7.47%. The identification of the Garcinia mangostanahusk extract was carried out by thin-layer chromatography (TLC) and differential scanning calorimetry. The TLC of mangostin was done by using the alumina sheet and ethyl acetate: hexane (3:1) as mobile phase. The Rf value as compared with standard mangostin was

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5

Randen, Neil A. Controlled-Release Personal Use Arthropod Repellent Formulation. Phase 2. Defense Technical Information Center, 1986. http://dx.doi.org/10.21236/adb112150.

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6

Randen, Neil A. Controlled-Release Personal Use Arthropod Repellent Formulation. Phase 3. Defense Technical Information Center, 1987. http://dx.doi.org/10.21236/adb116939.

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7

Killorn, Randy, Marianela Gonzalez, Jeffrey Moore, and David Haden. Effect of Controlled-Release N Fertilizer on Corn Grain Yield. Iowa State University, Digital Repository, 2006. http://dx.doi.org/10.31274/farmprogressreports-180814-621.

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8

Citarrella, Maria Clara, Emmanuel Fortunato Gulino, and Roberto Scaffaro. Green composites for fertilizer controlled release produced by compression molding and FDM. Peeref, 2023. http://dx.doi.org/10.54985/peeref.2303p8203188.

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9

Sirivat, Anuvat. Electrically controlled release of drugs from alginate hydrogels for transdermal drug delivery application. Chulalongkorn University, 2014. https://doi.org/10.58837/chula.res.2014.80.

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A drug-loaded conductive polymer/hydrogel blend, benzoic acid-loaded poly(3,4-ethylenedioxythiophene/alginate (BA-loaded PEDOT/Alg) hydrogel, was used as a carrier/matrix for an electrical stimuli transdermal drug delivery system (TDDS). The effects of crosslinking ratio, PEDOT particle size, and electric field strength on the release mechanism and the diffusion coefficient (D) of BA were examined by using a modified Franz-diffusion cell. The diffusion scaling exponent value of BA is close to 0.5 which refers to the diffusion controlled mechanism, or the Fickian diffusion as the BA release mec

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10

Kardon, Randy. Treatment of Laser-Induced Retinal Injury and Visual Loss Using Sustained Release of Intra-Vitreal Neurotrophic Growth Factors. Addendum. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada558524.

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