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Letteratura scientifica selezionata sul tema "Critic genetics"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 11 febbraio 2022

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Articoli di riviste sul tema "Critic genetics"

Morimura, Tetsuro, Eiji Uchibe e Kenji Doya. "Natural actor-critic with baseline adjustment for variance reduction". Artificial Life and Robotics 13, n. 1 (dicembre 2008): 275–79. http://dx.doi.org/10.1007/s10015-008-0514-8.

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Itoh, Hideaki, e Kazuyuki Aihara. "Combination of an actor/critic algorithm with goal-directed reasoning". Artificial Life and Robotics 5, n. 4 (dicembre 2001): 233–41. http://dx.doi.org/10.1007/bf02481507.

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Ahn, Inkyung, e Jooyoung Park. "Drug scheduling of cancer chemotherapy based on natural actor-critic approach". Biosystems 106, n. 2-3 (novembre 2011): 121–29. http://dx.doi.org/10.1016/j.biosystems.2011.07.005.

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Makino, Kenji, Yutaka Nakamura, Tomohiro Shibata e Shin Ishii. "Adaptive control of a looper-like robot based on the CPG-actor-critic method". Artificial Life and Robotics 12, n. 1-2 (marzo 2008): 129–32. http://dx.doi.org/10.1007/s10015-007-0453-9.

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Frémaux, Nicolas, Henning Sprekeler e Wulfram Gerstner. "Reinforcement Learning Using a Continuous Time Actor-Critic Framework with Spiking Neurons". PLoS Computational Biology 9, n. 4 (11 aprile 2013): e1003024. http://dx.doi.org/10.1371/journal.pcbi.1003024.

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Bystrov, Vladimir, e Vladimir Kamnev. "Vulgar Sociologism: The History of the Concept". Sotsiologicheskoe Obozrenie / Russian Sociological Review 18, n. 3 (2019): 286–308. http://dx.doi.org/10.17323/1728-192x-2019-3-286-308.

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This article can be considered as the history of the concept of vulgar sociologism, including both the moment of the emergence of this concept and its subsequent history. In the 20th century, new approaches were formed in the natural sciences about society and man which assumed to consider all of the ideas from the point of view of class psycho-ideology. This approach manifested itself somewhat in the history of philosophical and scientific knowledge, but chiefly in literary criticism (Friche, Pereverzev). As a result, any work of art turns into a ciphered message behind which the interest of a certain class or group hides. The critic has to solve this code and define its sociological equivalent. In the discussions against vulgar sociology, M. Lifshitz and his adherents insisted on a limitation of the vulgar-sociological approach, qualifying it as a bourgeois perversion of Marxism. They saw the principle of the criticism of vulgar sociology in the well-known statement by K. Marx about the aesthetic value of the Ancient Greek epos. The task of the critic does not only reduce to the establishment of social genetics of the work of art because he also needs to explain why this work causes aesthetic pleasure during other historical eras. In the article, it is shown that later attempts to reduce the complete spectrum of modern western philosophy and aesthetics into a paradigm of vulgar sociology of the 1920s is an unreasonable exaggeration. At the same time, in discussions in the 1930s, the question of the need of the differentiation of the vulgar-sociological approach and a sociological method in general was raised. As for sociology, this question remains relevant even today.

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Mannella, Francesco, e Gianluca Baldassarre. "A neural-network reinforcement-learning model of domestic chicks that learn to localize the centre of closed arenas". Philosophical Transactions of the Royal Society B: Biological Sciences 362, n. 1479 (11 gennaio 2007): 383–401. http://dx.doi.org/10.1098/rstb.2006.1966.

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Previous experiments have shown that when domestic chicks ( Gallus gallus ) are first trained to locate food elements hidden at the centre of a closed square arena and then are tested in a square arena of double the size, they search for food both at its centre and at a distance from walls similar to the distance of the centre from the walls experienced during training. This paper presents a computational model that successfully reproduces these behaviours. The model is based on a neural-network implementation of the reinforcement-learning actor–critic architecture (in this architecture the ‘critic’ learns to evaluate perceived states in terms of predicted future rewards, while the ‘actor’ learns to increase the probability of selecting the actions that lead to higher evaluations). The analysis of the model suggests which type of information and cognitive mechanisms might underlie chicks' behaviours: (i) the tendency to explore the area at a specific distance from walls might be based on the processing of the height of walls' horizontal edges, (ii) the capacity to generalize the search at the centre of square arenas independently of their size might be based on the processing of the relative position of walls' vertical edges on the horizontal plane (equalization of walls' width), and (iii) the whole behaviour exhibited in the large square arena can be reproduced by assuming the existence of an attention process that, at each time, focuses chicks' internal processing on either one of the two previously discussed information sources. The model also produces testable predictions regarding the generalization capabilities that real chicks should exhibit if trained in circular arenas of varying size. The paper also highlights the potentialities of the model to address other experiments on animals' navigation and analyses its strengths and weaknesses in comparison to other models.

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Singh, Rama S. "Darwin’s legacy: why biology is not physics, or why evolution has not become a common sense1Award Lecture, Genetics Society of Canada P. Moens and W.F. Grant Award of Excellence, 2010. / Conférence du récipiendaire, Prix d’excellence P. Moens et W.F. Grant de la Société de Génétique du Canada, 2010." Genome 54, n. 10 (ottobre 2011): 868–73. http://dx.doi.org/10.1139/g11-046.

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Cosmology and evolution together have enabled us to look deep into the past and comprehend evolution—from the big bang to the cosmos, from molecules to humans. Here, I compare the nature of theories in biology and physics and ask why physical theories get accepted by the public without necessarily comprehending them but biological theories do not. Darwin’s theory of natural selection, utterly simple in its premises but profound in its consequences, is not accepted widely. Organized religions, and creationists in particularly, have been the major critic of evolution, but not all opposition to evolution comes from organized religions. A great many people, between evolutionary biologists on one hand and creationists on the other, many academics included, who may not be logically opposed to evolution nevertheless do not accept it. This is because the process of and the evidence for evolution are invisible to a nonspecialist, or the theory may look too simple to explain complex traits to some, or because people compare evolution against God and find evolutionary explanations threatening to their beliefs. Considering how evolution affects our lives, including health and the environment to give just two examples, a basic course in evolution should become a required component of all our college and university educational systems.

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Hatakeyama, Hiroyuki, Shingo Mabu, Kotaro Hirasawa e Jinglu Hu. "Genetic Network Programming with Actor-Critic". Journal of Advanced Computational Intelligence and Intelligent Informatics 11, n. 1 (20 gennaio 2007): 79–86. http://dx.doi.org/10.20965/jaciii.2007.p0079.

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A new graph-based evolutionary algorithm named “Genetic Network Programming, GNP” has been already proposed. GNP represents its solutions as graph structures, which can improve the expression ability and performance. In addition, GNP with Reinforcement Learning (GNP-RL) was proposed a few years ago. Since GNP-RL can do reinforcement learning during task execution in addition to evolution after task execution, it can search for solutions efficiently. In this paper, GNP with Actor-Critic (GNP-AC) which is a new type of GNP-RL is proposed. Originally, GNP deals with discrete information, but GNP-AC aims to deal with continuous information. The proposed method is applied to the controller of the Khepera simulator and its performance is evaluated.

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Condit, Celeste M. "How the public understands genetics: non-deterministic and non-discriminatory interpretations of the “blueprint” metaphor". Public Understanding of Science 8, n. 3 (luglio 1999): 169–80. http://dx.doi.org/10.1088/0963-6625/8/3/302.

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Critics have worried that recent mass media coverage of genetics encourages genetic determinism and discriminatory attitudes in the public. They have identified the “blueprint” metaphor as one major component of public discourse that encourages such undesirable public opinions. To assess public interpretations of popular discourse about genetics, this audience study exposed 137 college students to sample genetics news articles and asked for their interpretations of the “blueprint” metaphor and of genetics in general. A larger group, the plurality, offered non-deterministic interpretations and perspectives on genetics. A small minority offered discriminatory interpretations, whereas a plurality offered explicit antidiscriminatory interpretations and opinions. Non-deterministic views were based on interpretations of the blueprint metaphor that understood genes as operating in a partial and probabilistic fashion, and that interpreted genes as malleable through individual will or technological intervention.

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Più fonti

Tesi sul tema "Critic genetics"

Vieira, Karine Moura. "O desafio de narrar uma vida : a crítica genética no estudo da biografia como gênero jornalístico". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/30217.

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Esta dissertação analisa a biografia como gênero jornalístico através da aplicação dos procedimentos da Crítica Genética ao processo de produção da obra Padre Cícero – poder, fé e guerra no sertão, do jornalista Lira Neto. Procura-se identificar e compreender as características e especificidades que podem vir a definir a biografia como um gênero jornalístico - critérios de noticiabilidade, valores-notícia, tratamento e relação com as fontes e as estratégias comunicativas utilizadas para produzir a narrativa. Para tanto, realiza-se um estudo de gênese dos documentos, cadernetas e manuscritos que constituem os vestígios de produção da obra. Compreende-se que a biografia origina-se e desenvolve-se na fronteira entre a história e a literatura e constitui-se no jornalismo em aproximação com a reportagem, como uma narrativa de reconstituição que se constrói no devir da história de vida do biografado, estabelecendo uma nova identidade narrativa do personagem.
This thesis analyzes the biography as a genre of journalism by applying the procedures of Genetic Criticism of the production process of the work Padre Cícero – poder, fé e guerra no sertão, of the journalist Lira Neto. It seeks to identify and understand the characteristics and needs that may define the biography as a journalistic genre - criteria of newsworthiness, news values, treatment and relationship with sources and communication strategies used to produce the narrative. The study presents a study of the genesis of docume nts, books and manuscripts which are the remains of the production work. It is understood that the biography originates and develops at the border between history and literature and in journalism is approaching with the story as a narrative reconstruction that builds upon the transformation of the life history of the biography, by establishing a new narrative identity of the character.

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Aston, Elizabeth Jane. "Critical mutation rates in small populations". Thesis, Keele University, 2014. http://eprints.keele.ac.uk/1321/.

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Mutation introduces change at the sequence level. There is a critical mutation rate above which changes occur too frequently for natural selection to maintain the population's genetic makeup. This thesis examines the relationship between this critical mutation rate and the number of individuals in the adapting population. It presents an algorithmic method capable of providing widely applicable results in haploid and diploid populations, and varies this method against analytical models for the error threshold. Use of the method led to the discovery of an exponential relationship between the critical mutation rate and population size, particularly strong in small populations with 100 individuals or less, contradicting the existing idea that critical mutation rate and population size are independent. The critical mutation rate (and error threshold) were found to be lower in diploids due to differences in recombination. Analysis of the survival-of-the-fittest to survival-of-the-flattest transition enabled improvement of existing definitions of the critical mutation rate. Development of a faster algorithm capable of running experiments with parameter values within the range found in nature began the process of bridging the gap between artificial and biological evolution. A link was established between the exponential model and natural mutation rates. Increasing the gene length by a factor of 10 was found to decrease both the critical mutation rate and error threshold by an order of magnitude. Natural mutation rates lie below these values, although further work is required to establish any trend. A potential link has been established between the critical mutation rate, error threshold, and optimal mutation rate control theory. Future work may develop the algorithmic method to include more complex features of biological populations, and go on to determine the effect the exponential model can have on population extinction, recovery, and conservation.

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Johansson, Christian, e Gustav Evertsson. "Optimizing Genetic Algorithms for Time Critical Problems". Thesis, Blekinge Tekniska Högskola, Institutionen för programvaruteknik och datavetenskap, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4993.

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Genetic algorithms have a lot of properties that makes it a good choice when one needs to solve very complicated problems. The performance of genetic algorithms is affected by the parameters that are used. Optimization of the parameters for the genetic algorithm is one of the most popular research fields of genetic algorithms. One of the reasons for this is because of the complicated relation between the parameters and factors such as the complexity of the problem. This thesis describes what happens when time constraints are added to this problem. One of the most important parameters is population size and we have found by testing a well known set of optimization benchmark problems that the optimal population size is not the same when time constraints were involved.
Genetiska algoritmer har många egenskaper som gör dem till ett bra val när man ska lösa väldigt komplicerade problem. Prestandan för genetiska algoritmer påverkas av de parametrar som används. Optimering av parametrarna för genetiska algoritmer är ett av de mest populära forskningsområdena för genetiska algoritmer. En av anledningarna till detta är den komplexa relationen mellan parametrarna och faktorer så som komplexiteten av problemet. Detta arbete beskriver vad som händer när tidsfaktorn läggs till detta problem. En av de viktigaste parametrarna är populationsstorlek och vi har sett genom att testa en grupp med väl testade optimiseringsproblem att optimal populationsstorlek inte är samma när tidsfaktorn är inblandat.

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Difford, Gareth Frank. "Critical assessment of the “internal reference” method to eliminate non-genetic effects within a Combined Family Selection program on the abalone species (Haliotis midae)". Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85658.

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Thesis (MScAgric)--Stellenbosch University, 2013.
ENGLISH ABSTRACT: The aim of this study was to critically assess the implementation of the internal reference method within the most recent 173 full-sibling growth trial of the Innovation Fund Abalone Breeding Project. The trial was conducted over two locations for a period of five years, with minimal replication for the majority of test families and a single full-sibling family was entered into each experimental unit (basket) as an internal reference group. The primary focus was firstly, to validate the performance of the internal reference group as a control for comparisons and correction of environmental variation in test family performances. Secondly, to identify areas of weakness and either make recommendations to remedy areas of weakness or justify devoting resources to alternative methods of reducing extraneous environmental variance with limitations on replication. The efficiency and statistical power associated with utilising internal reference information as a covariate and for manual correction respectively were examined for the 6 full-sibling test families that were replicated. This study reports on the evaluation of factors which are potential sources of bias in the internal reference method, the first of which, tag loss, was found to be significant after 6- 12 months. However, it was not found to bias internal reference group performances as the factors which contribute to tag loss were found to act randomly. Variability in size ratio of internal reference to test family at co-stocking proved a significant source of bias, as reference groups smaller than their test family counterparts had reduced performances. Testing for genotype by environment interactions was precluded due to the inherent lack of replication and the subsequent confounding of genotype effects with inter-rearing structure effects at one of the locations. However, significant differences were detected for both traits of interest of the internal reference group over the two locations. Significant antagonistic interactions were detected and identified as a source of bias for average daily weight gain of replicate test families. The evaluation of average daily length gain for the efficiency of adjustment when the internal reference is a covariate and the change in statistical power when the internal reference is used for a manual correction, yielded conflicting results. The latter shows a decrease in statistical power and the former shows an increase in efficiency, both resulting in poor goodness of fit in the respective models. There was however evidence that when no antagonistic interactions occurred “between replicate variance” decreased and therefore the internal reference method has statistical merit provided all critical success factors are satisfied. Recommendations were made for future implementation of the internal reference method to facilitate adequate statistical testing for sources of bias and the prevention thereof. Additionally, an alternative method which may have merit in decreasing environmental variance and the need for replication, is discussed.
AFRIKAANSE OPSOMMING: Die doel van die studie was om die gebruik van ŉ interne verwysingsgroep te ontleed, soos toegepas tydens die evaluering van 173 volsib families as deel van die Innovasiefonds Perlemoen Teelprogram. Die evaluering is gedoen op twee lokaliteite oor 'n tydperk van vyf jaar, met minimale replikasie van die toets families en die gebruik van ‘n enkele volsib familie as 'n interne verwysingsgroep in elke eksperimentele eenheid (mandjie). Die primêre fokus was eerstens om die gebruik van die interne verwysingsgroep vir die korreksie van omgewingsvariasie in die toets familie optredes te evalueer. Tweedens, om spesifieke gebreke te identifiseer ten opsigte van die gebruik van die interne verwysingsgroep en aanbevelings maak dit reg te stel en om die meriete van alternatiewe metodes te oorweeg. Die doeltreffendheid en statistiese onderskeidingsvermoë van die gebruik van interne verwysingsgroep as 'n kovariaat is ondersoek met betrekking tot die 6 volsib groepe wat oor voldoende replikasies beskik het. Die studie doen voorts verslag oor die evaluering van potensiële oorsake van sydigheid ten opsigte van die gebruik van die interne verwysingsgroep, insluitend die beduidende verlies van identifikasie vanaf 6 tot 12 maande. Geen aanduiding van sydigheid is egter gevind en die aanleidende oorsake van verlies van identifikasie blyk van ŉ ewekansige aard te wees. Verskille in die grootte tussen die interne verwysingsgroep en toets-families met aanvang van evaluering blyk 'n belangrike bron van sydigheid te wees, waar die kleiner groepering aan verminderde prestasie gekoppel word. Bepaling van genotipe-omgewing-interaksies kon nie uitgevoer word nie as gevolg van die inherente gebrek van replisering oor lokaliteite. Beduidende verskille is egter waargeneem tussen interne verwysingsgroepe oor die twee lokasies ten opsigte van die beide groei eienskappe. Beduidende antagonistiese interaksies is waargeneem en geïdentifiseer as 'n bron van sydigheid ten opsigte van die gemiddelde daaglikse gewigstoename van replikaat toetsfamilies. Die evaluering van gemiddelde daaglikse lengtetoename met die interne verwysingsgroep as is 'n kovariaat en die verandering in statistiese ontledingsvermoë tydens die gebruik van die interne verwysingsgroep het teenstrydige resultate opgelewer. Laasgenoemde toon 'n afname in statistiese ontledingsvermoë en die eersgenoemde toon 'n toename in doeltreffendheid, met beide swak passing op die onderskeie modelle. In die afwesigheid van antagonistiese interaksies tussen replikasies het variansie afgeneem en beskik die interne verwysingsgroep oor die nodige statistiese meriete indien daar aan al die kritiese vereistes voldoen word. Aanbevelings is gemaak ten opsigte van die toekomstige implementering van die interne verwysingsmetode met verwysing na voldoende statistiese toetsing vir bronne van sydigheid en die voorkoming daarvan. 'n Verdere metode wat oor die nodige meriete beskik om die omgewingsvariasie en die noodsaaklikheid vir replikasie te verminder, word bespreek.

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French, Graham Christopher. "Conservation genetics of the critical plant genus Euphrasia L. in Britain". Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/13856.

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Recent national and international conservation legislation has led to an increased focus on ‘prioritised species lists’ for the allocation of conservation resources. However, prioritised species lists become problematic when there are difficulties in species delimitation. One particularly complex group accounting for the majority of these problems is Euphrasia. The goal of this thesis is to use molecular markers to evaluate taxon limits and evolutionary processes in British Euphrasia to clarify the most appropriate approach for conservation. The results show that the major reproductive barrier in the group corresponds to ploidy level, with AFLP and chloroplast data both significantly differentiated between diploid and tetraploid species, although occasional gene flow via inter-ploidal hybridisation appears to contribute towards diversification of the diploid group. The genetic data support the current species level taxonomy for the diploid but not the tetraploid species, where a considerable overlap between taxa was detected. The chloroplast data detected four discrete lineages, the distribution of these among species suggest at least three allopolyploid events in the formation of the tetraploid taxa, within which distinct ecological groups occur. Variation in the breeding system was detected at the intra- and inter-specific levels and estimates of the inbreeding coefficient showed a strong correlation with flower size and support the importance of multiple shifts in breeding system as contributing towards the overall diversification within the group. Given the lack of clear species limits in the tetraploid group and the dynamic nature of Euphrasia evolution, a change from a species- to process-based conservation approach is recommended. This charge include recognising the importance of progenitor taxa, and ecological and morphological diversity, and a decrease in the importance presently given to individual named endemic taxa.

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Duty, Timothy Lee. "Broken symmetry and critical phenomena in population genetics : the stepping-stone model". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/NQ56536.pdf.

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Richardson, Rose. "The critical role of p63 during palatal shelf fusion". Thesis, University of Manchester, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634942.

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Cleft palate affects approximately 1 in 2000 live births resulting in considerable morbidity to affected individuals and their families. Evidence that the p63 gene is mutated in at least seven human developmental syndromes which are each characterised by varying extents of orofacial clefting, coupled to the severe facial dysmorphism displayed by the p63 mutant mouse, highlight the need to elucidate the role of the p63 during normal and aberrant palatogenesis. In mice, secondary palate development closely mirrors that occurring in humans; consequently, the mouse is a pre-eminent model organism for studying palatogenesis. In mice, the palatal shelves initiate from the maxillary processes and grow vertically, lateral to the tongue. The shelves re-orientate and make contact above the tongue. The medial edge epithelia (MEE) of the apposed palatal shelves adhere to form a midline epithelial seam (MES). Subsequent degeneration of the MES allows mesenchymal confluence across the palate, at which point palatogenesis is considered complete. The mechanisms underlying degeneration of the MES remain contentious; however, in vivo studies suggest that cessation of proliferation, induction of apoptosis and periderm migration are essential to ensure removal of the midline seam. The data presented in this thesis uncover a key role for p63 in controlling these aspects of cell behaviour during palatal shelf fusion. Tgfb3-/- mice exhibit cleft palate with maintained expression of p63 in the MEE. This thesis reveals that epistatically lowering the dosage of p63 in Tgfb3-/- mice rescues this fusion defect, facilitating periderm cell migration out of the MEE and subsequent MES degradation. Recent research suggests that p63 orchestrates a cell adhesion network in the palate. In this context, this thesis suggests the importance of p63 down-regulation in the MES in compromising adhesion at the basal-periderm border, thereby allowing periderm cell migration out from the midline and subsequent MES degradation. To test the hypothesis that down-regulation of p63 is essential for palatal fusion, tetracycline-inducible transgenic animals in which ΔNp63α is targeted to the MEE of the developing palate have been engineered. ΔNp63α bi-transgenic mice presented with cleft palate in which the MES failed to degenerate. An observed lack of apoptotic activity in the MEE of ΔNp63α bi-transgenic mice suggested a role for p63-mediated apoptosis during MES degradation. Gene ontology analysis of a complete range of ΔNp63α transcriptional targets which have been identified in the secondary palate by ChIP-seq, lent support to this hypothesis. The data indicate that p63 down-regulation in the MES is essential to ensure complete removal of the MES and implicate p63 as a key regulator of apoptosis during this process; thereby building on work which suggests that cell death is the major fate of the MEE. In addition to dissecting a pathway of fundamental importance in secondary palate development, this research provides insights into ectodermal development more generally and has wider significance for the study of many congenital malformations.

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Eggers, Ben. "Identifying phenotypic traits critical for breeding winter malting barley adapted to Ohio and the genomic regions affecting those traits". The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1607035449218475.

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Appanah, Rowin. "Replisome-mediated homeostasis of DNA/RNA hybrids in eukaryotic genomes is critical for cell fates and chromatin stability". Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/100501/.

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During DNA replication, forks often stall upon encountering obstacles blocking their progression. Cells will act to speedily remove or overcome such barriers, thus allowing complete synthesis of chromosomes. This is the case for R-loops, DNA/RNA hybrids that arise during transcription. One mechanism to remove such R-loops involve DNA/RNA helicases. Here, I have shown that one such helicase, Sen1, associates with replisome components during S phase in the model organism S. cerevisiae. I demonstrate that the N-terminal domain of Sen1 is both sufficient and necessary for the interaction of the protein with the replisome. I also identified Ctf4 as one of at least two replisome interactors of Sen1. By mutational analysis, a mutant of Sen1 (Sen1-3) that cannot interact with the replisome was created. This mutant is healthy on its own but is lethal in the absence of both RNase H1 and H2. Overexpression of the sen1-3 allele from the constitutive ACT1 promoter is able to suppress this synthetic lethality, suggesting that Sen1 travels with replisomes in order to be quickly recruited at sites of R-loops that impair fork progression so as to remove those R-loops. In some cases, cells exploit fork stalling for biologically important processes. This is the case in Sz. pombe, where an imprint prevents complete DNA replication, triggering cell-type switching. This imprint is dependent on Pol1, a component of the replisome. Importantly, a single imprinting-defective allele of pol1 has been identified to date. Using in vitro assays, I have shown that this Pol1 mutant has reduced affinity for its substrates and is a correspondingly poor polymerase. By generating novel alleles of pol1, I have also demonstrated that switching-deficiency correlates with the affinity of Pol1 for its substrates in vivo. Finally, two interactors of Pol1 (Mcl1Ctf4 and Spp1Pri1 ) have been shown to have switching defects. S. cerevisiae and Sz. pombe have similar yet distinct genetic nomenclature conventions. Given that both model organisms were used in this study, it is important to highlight the conventions for both organisms to prevent confusion. In S. cerevisiae, wildtype gene names are expressed as a three letter, uppercase and italic name followed by a number (e.g. SEN1). The three letter name often corresponds to the screen through which the gene in question was originally identified. Mutants are generally designated with the same three letter but in lower case (unless the mutant is dominant) and with an allele designation (e.g. sen1∆, sen1-1 and sen1-2). Because of historical context, the allele designations vary in format (e.g. leu2-3,112 is a mutant of LEU2). Protein names are given as a three letter name with the first letter in uppercase (e.g. Sen1). This is also true for mutant proteins, with the added allele designation (e.g Sen1-1 and Sen1-2). In this study, I have generated constructs of the SEN1 gene and these constructs are referred to as SEN1 (X-Y), where X and Y refer to the first and last residues being encoded for. The corresponding proteins are referred to as Sen1 (X-Y). Different promoters have been used and, where appropriate, the promoters are expressed similarly to their wildtype gene names (e.g. GAL1, SEN1 and ACT1). In Sz. pombe, wildtype gene names are expressed as a three letter, lowercase and italic name followed by a number (e.g. pol1). Mutants are generally designated in the same format but with an allele designation. Like in S. cerevisiae, the allele designation varies widely (e.g. pol1-1, pol1-H4 and pol1-ts13). Additionally, because of the historical context, some (but not all) alleles of pol1 are referred to as swi7 to reflect the fact that they are defective for cell-type switching. Similar to the situation in S. cerevisiae, proteins names are given as a three letter name with the first letter in uppercase for both wildtype and mutants (e.g. Pol1 and Swi7-1). Sometimes, for the sake of comparison, genes or proteins are referred to their S. cerevisiae orthologues (e.g. swi1TOF1 and Swi1Tof1 , respectively). Several protein tags have been used in this study. When written in gene form, they were written in capital letters and italicized, irrespective of the host (e.g. 5FLAG) and when in protein form, they were written in capital, irrespective of the host (e.g. 5FLAG).

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Silva, Joyce do Rosario da. "Analise critica da expressão do gene da mucina 1(MUC1) no carcinoma papilifero da tireoide : correlações clinicas e anatomo-patologicas". [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310273.

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Orientador: Laura Sterian Ward
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-13T00:19:00Z (GMT). No. of bitstreams: 1 Silva_JoycedoRosarioda_D.pdf: 4211439 bytes, checksum: d230e48c7d6fd16a7f9c75667ad83f9a (MD5) Previous issue date: 2009
Resumo: A maior expressão de MUC1 tem sido relacionada com o pior prognóstico de diversas malignidades como o câncer de mama e pâncreas. Aproximadamente 20% dos carcinomas diferenciados da tiróide (CDT) evoluem com recidivas locais e a distância. O nosso objetivo foi o de avaliar o gene da MUC1 nos pacientes com CDT e relacionar com aspectos clínicos e anatomo-patológicos. CASUÍSTICA E MÉTODOS: Selecionamos 150 pacientes portadores de carcinoma papilífero (CP), 57 oriundos do Hospital das Clínicas da UNICAMP, acompanhados por 67 (73,29±39,83) meses, de 1995 a 2008 e 93 pacientes do Hospital AC Camargo - Fundação Antônio Prudente em São Paulo acompanhados por 41,37 (32,5±34,30) meses, de 1998 a 2008. Realizamos análise da expressão do gene da MUC 1 por imunoistoquímica e por PCR em Tempo Real e comparamos com dados de evolução clínica e do anatomopatológico. RESULTADOS: Observamos a expressão da proteína MUC1 em 82,19% dos pacientes com CP, no entanto, sem diferenças estatísticas para os dados de evolução clínica e do anatomo-patológico. A análise do RNA-m de MUC1 se correlacionou com a menor expressão nos indivíduos que apresentaram metástases ao diagnóstico (p valor=0,0216). Observamos a pior evolução: no sexo masculino, quando havia metástases ao diagnóstico, na ausência de tiroidite e nos tumores maiores que 4 cm. A presença de invasão tumoral foi mais freqüente nos indivíduos com ausência de tiroidite em 47% dos casos (p=0,0132; OR 2,473 - 95%IC: 1,198-5,104). CONCLUSÃO: Não conseguimos correlacionar a análise do gene MUC1 com aspectos clínicos e anatomo-patológicos de pior prognóstico para o CDT.
Abstract: The over expression of MUC1 has been related with the worst prognosis in malignancies like breast and pancreas cancer. We know that around 20% of the patients with differentiated thyroid cancer (DTC) can develop local and/or distant recurrences and because of that we decide to analyze the MUC1 gene in patients with DTC and tried to relate it with clinical and pathological patterns of the thyroid cancer. PATIENTS AND METHODS: We selected 150 patients with Papillary Thyroid Cancer: 57 from the Clinical Hospital of Campinas State University, followed up for 67 (73,29±39,83) months, since 1995 to 2008 and 93 patients from the A. C. Camargo Hospital - Antonio Prudente Foundation - São Paulo for 41,37 (32,5±34,3) months since 1998 to 2008. We analyzed the MUC1 gene with the immunohistochemistry and the Real Time - PCR techniques and compared the results with clinical and pathological data. RESULTS: The MUC1 expression was positive in 82,19% of the patients with papillary thyroid cancer, however, when we compared with clinical and pathological data, there was not statistical significance. The MUC1 m-RNA analysis was correlated with the less expression of the gene in the individuals who had had metastases at the diagnosis. We could observe the worst outcome in the individuals of the male gender, in the presence of metastases at the diagnosis, in the absence of thyroiditis in the non-neoplasic tissue and in tumors larger than 4 cm. The presence of tumoral invasion was significant in the patients with metastases to the diagnosis and in the ones without thyroiditis in 47% (p=0,0132; OR 2,473 - 95% CI: 1,198-5,104). CONCLUSION: We conclude that MUC1gene analysis was not useful to determine aggressive tumors nor to predict prognosis in papillary thyroid carcinomas.
Doutorado
Clinica Medica
Doutor em Clínica Médica

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Bellino, Raffaello Maria. Critica della ragione predittiva: L'etica tra scienza e nescienza. Bari: Levante, 2004.

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Understanding genetics. 4^a ed. New York: Oxford University Press, 1988.

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1883-1945, Mussolini Benito, a cura di. I discorsi del Duce: Un approccio critico-genetico. Ariccia (RM): Aracne editrice int.le S.r.l., 2015.

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Rothwell, Norman V. Understanding genetics: A molecular approach. New York: Wiley-Liss, 1993.

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Eugenics, human genetics, and human failings: The Eugenics Society, its sources and its critics in Britain. London: Routledge, 1992.

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Mazumdar, Pauline M. H. Eugenics, human genetics and human failings: The Eugenics Society, its source and its critics in Britain. London: Routledge, 1991.

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Comment c'est =: How it is ; and / et L'image : a critical-genetic edition = une édition critico-génétique. New York: Routledge, 2001.

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Filologia d'autore e critica genetica: Terzo quaderno del Dottorato in letterature straniere e scienze della letteratura, Università di Verona. Verona: Fiorini, 2009.

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Gattico, Emilio. Logica e psicologia nella cultura italiana del XIX secolo: Un tema di epistemologia genetica : analisi storico-critica della letteratura filosofica minore. Firenze: La nuova Italia, 1995.

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Viruses vs. superbugs: A solution to the antibiotics crisis? London: Macmillan, 2006.

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Capitoli di libri sul tema "Critic genetics"

Joseph, Jay. "Behavioral Genetics". In Encyclopedia of Critical Psychology, 151–56. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-5583-7_25.

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O’Doherty, Kieran C. "Genetic Counseling, Overview". In Encyclopedia of Critical Psychology, 774–79. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-5583-7_639.

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Steiling, Katrina, e Joshua D. Campbell. "Genetics of Lung Cancer". In Precision in Pulmonary, Critical Care, and Sleep Medicine, 87–103. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-31507-8_7.

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Schmid, Hans-Peter, Ladislav Prikler e Axel Semjonow. "Problems with Prostate-Specific Antigen Screening: A Critical Review". In Tumor Prevention and Genetics, 226–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55647-0_20.

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Cohen, M. Michael. "A Comprehensive and Critical Assessment of Overgrowth and Overgrowth Syndromes". In Advances in Human Genetics, 181–303. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0785-3_4.

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Mathai, Susan K., e David A. Schwartz. "Genetics of Idiopathic Pulmonary Fibrosis". In Precision in Pulmonary, Critical Care, and Sleep Medicine, 71–85. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-31507-8_6.

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Kan, Mengyuan, e Blanca E. Himes. "Genetics and Pharmacogenetics of Asthma". In Precision in Pulmonary, Critical Care, and Sleep Medicine, 25–37. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-31507-8_3.

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Bossé, Yohan, e Michael H. Cho. "Genetics and Pharmacogenetics of COPD". In Precision in Pulmonary, Critical Care, and Sleep Medicine, 39–55. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-31507-8_4.

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Pfleiderer, Georg, Gabriela Brahier e Klaus Lindpaintner. "Beyond Playing God: Critical Religious GenEthics for Pluralistic Societies". In GenEthics and Religion, 1–11. Basel: KARGER, 2010. http://dx.doi.org/10.1159/000315446.

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Prom-Wormley, Elizabeth, Amy Adkins, Irwin D. Waldman e Danielle Dick. "Critical Issues in Genetic Association Studies". In Psychological Science Under Scrutiny, 221–49. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119095910.ch12.

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Atti di convegni sul tema "Critic genetics"

Smith, Robert E. "Genetic and evolutionary systems". In Critical Review Collection. SPIE, 1994. http://dx.doi.org/10.1117/12.171199.

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Peng, Yiming, Gang Chen, Scott Holdaway, Yi Mei e Mengjie Zhang. "Automated state feature learning for actor-critic reinforcement learning through NEAT". In GECCO '17: Genetic and Evolutionary Computation Conference. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3067695.3076035.

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Johnson, Eric G., Alan D. Kathman, Diane H. Hochmuth, A. L. Cook, David R. Brown e William F. Delaney. "Advantages of genetic algorithm optimization methods in diffractive optic design". In Critical Review Collection. SPIE, 1993. http://dx.doi.org/10.1117/12.170193.

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Dubrovka, F. F., e D. A. Vasylenko. "Neural-genetic method applied to the design of Vivaldi antenna". In Telecommunication Technology" (CriMiCo 2008). IEEE, 2008. http://dx.doi.org/10.1109/crmico.2008.4676441.

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Dorofeev, S. Yu, e L. I. Babak. "Synthesys of lumped- and distributed-element matching networks using the genetic algorithm". In Telecommunication Technology" (CriMiCo 2008). IEEE, 2008. http://dx.doi.org/10.1109/crmico.2008.4676319.

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Zhou, Yangming, e Jin-Kao Hao. "A fast heuristic algorithm for the critical node problem". In GECCO '17: Genetic and Evolutionary Computation Conference. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3067695.3075993.

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Shingo Mabu, Yan Chen, Kotaro Hirasawa e Jinglu Hu. "Stock trading rules using genetic network programming with actor-critic". In 2007 IEEE Congress on Evolutionary Computation. IEEE, 2007. http://dx.doi.org/10.1109/cec.2007.4424513.

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Saenko, Igor, e Igor Kotenko. "Genetic algorithms for role mining in critical infrastructure data spaces". In GECCO '18: Genetic and Evolutionary Computation Conference. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3205651.3208283.

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Askari, Qamar, Irfan Younas e Mehreen Saeed. "Critical evaluation of sine cosine algorithm and a few recommendations". In GECCO '20: Genetic and Evolutionary Computation Conference. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3377929.3389982.

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Saenko, Igor, e Igor Kotenko. "A role-base approach and a genetic algorithm for VLAN design in large critical infrastructures". In GECCO '19: Genetic and Evolutionary Computation Conference. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3319619.3326853.

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Rapporti di organizzazioni sul tema "Critic genetics"

Fritz, Dominik Arthur. Genetic Algorithm Based Critical Experiment Design for Uranium Cross Section Validation. Office of Scientific and Technical Information (OSTI), agosto 2018. http://dx.doi.org/10.2172/1463589.

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Hutchinson, M. L., J. E. L. Corry e R. H. Madden. A review of the impact of food processing on antimicrobial-resistant bacteria in secondary processed meats and meat products. Food Standards Agency, ottobre 2020. http://dx.doi.org/10.46756/sci.fsa.bxn990.

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For meat and meat products, secondary processes are those that relate to the downstream of the primary chilling of carcasses. Secondary processes include maturation chilling, deboning, portioning, mincing and other operations such as thermal processing (cooking) that create fresh meat, meat preparations and ready-to-eat meat products. This review systematically identified and summarised information relating to antimicrobial resistance (AMR) during the manufacture of secondary processed meatand meat products (SPMMP). Systematic searching of eight literature databases was undertaken and the resultantpapers were appraised for relevance to AMR and SPMMP. Consideration was made that the appraisal scores, undertaken by different reviewers, were consistent. Appraisal reduced the 11,000 initially identified documents to 74, which indicated that literature relating to AMR and SPMMP was not plentiful. A wide range of laboratory methods and breakpoint values (i.e. the concentration of antimicrobial used to assess sensitivity, tolerance or resistance) were used for the isolation of AMR bacteria.The identified papers provided evidence that AMR bacteria could be routinely isolated from SPMMP. There was no evidence that either confirmed or refuted that genetic materials capable of increasing AMR in non-AMR bacteria were present unprotected (i.e. outside of a cell or a capsid) in SPMMP. Statistical analyses were not straightforward because different authors used different laboratory methodologies.However, analyses using antibiotic organised into broadly-related groups indicated that Enterobacteriaceaeresistant to third generation cephalosporins might be an area of upcoming concern in SPMMP. The effective treatment of patients infected with Enterobacteriaceaeresistant to cephalosporins are a known clinical issue. No AMR associations with geography were observed and most of the publications identified tended to be from Europe and the far east.AMR Listeria monocytogenes and lactic acid bacteria could be tolerant to cleaning and disinfection in secondary processing environments. The basis of the tolerance could be genetic (e.g. efflux pumps) or environmental (e.g. biofilm growth). Persistent, plant resident, AMR L. monocytogenes were shown by one study to be the source of final product contamination. 4 AMR genes can be present in bacterial cultures used for the manufacture of fermented SPMMP. Furthermore, there was broad evidence that AMR loci could be transferred during meat fermentation, with refrigeration temperatures curtailing transfer rates. Given the potential for AMR transfer, it may be prudent to advise food business operators (FBOs) to use fermentation starter cultures that are AMR-free or not contained within easily mobilisable genetic elements. Thermal processing was seen to be the only secondary processing stage that served as a critical control point for numbers of AMR bacteria. There were significant linkages between some AMR genes in Salmonella. Quaternary ammonium compound (QAC) resistance genes were associated with copper, tetracycline and sulphonamide resistance by virtue of co-location on the same plasmid. No evidence was found that either supported or refuted that there was any association between AMR genes and genes that encoded an altered stress response or enhanced the survival of AMR bacteria exposed to harmful environmental conditions.

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