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Articoli di riviste sul tema "Cyclodextrins"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Pashupati Nath Sharma, Pashupati Nath Sharma. "A Study of Hydroxypropyl Α-Cyclodextrin and Α-Cyclodextrin Inclusion Complexity". Journal of Advances and Scholarly Researches in Allied Education 19, № 3 (2022): 5–10. https://doi.org/10.29070/ag4ehh15.

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Cyclodextrins are generated with a range of readily available enzymes for the treatment of ordinary starch. Along with amylase, cyclodextrin glycosylotransferase is commonly used. The first is to liquify starch by thermal treatment or amylase and add CGTase to the enzyme conversion. The synthesis of all three types of cyclodextrins is possible at ratios that depend strictly on the enzyme used. Each CGTase has an independent synthesis relationship. Cyclodextrins are filtered according to their different water solubility CDs that are very poorly water-soluble can be easily crystallised while the

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2

Labes, Antje, and Peter Schönheit. "Unusual Starch Degradation Pathway via Cyclodextrins in the Hyperthermophilic Sulfate-Reducing Archaeon Archaeoglobus fulgidus Strain 7324." Journal of Bacteriology 189, no. 24 (2007): 8901–13. http://dx.doi.org/10.1128/jb.01136-07.

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ABSTRACT The hyperthermophilic archaeon Archaeoglobus fulgidus strain 7324 has been shown to grow on starch and sulfate and thus represents the first sulfate reducer able to degrade polymeric sugars. The enzymes involved in starch degradation to glucose 6-phosphate were studied. In extracts of starch-grown cells the activities of the classical starch degradation enzymes, α-amylase and amylopullulanase, could not be detected. Instead, evidence is presented here that A. fulgidus utilizes an unusual pathway of starch degradation involving cyclodextrins as intermediates. The pathway comprises the

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3

Bansal, Paramjit S., Craig L. Francis, Noel K. Hart та ін. "Regioselective Alkylation of β-Cyclodextrin". Australian Journal of Chemistry 51, № 10 (1998): 915. http://dx.doi.org/10.1071/c98064.

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Methodology for preparation of heptakis(2,6-di-O-alkyl)-β-cyclodextrins, heptakis(2-O-alkyl)-β- cyclodextrins, and heptakis(6-O-alkyl)-β-cyclodextrins in substantially purified form has been developed. Treatment of β-cyclodextrin (1) with sodium or barium hydroxide and various alkyl halides in dimethyl sulfoxide or a mixture of dimethyl sulfoxide and N,N-dimethylformamide provided the corresponding heptakis(2,6-di-O-alkyl)-β-cyclodextrins. Treatment of heptakis(6-O-t-butyldimethylsilyl)-β-cyclodextrin (5) with sodium hydroxide and several haloalkanes in dimethyl sulfoxide followed by desilylat

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4

Wang, Runmiao, Hui Zhou, Shirley W. I. Siu, Yong Gan, Yitao Wang, and Defang Ouyang. "Comparison of Three Molecular Simulation Approaches for Cyclodextrin-Ibuprofen Complexation." Journal of Nanomaterials 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/193049.

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Cyclodextrins are widely used for the solubilisation of poorly soluble drugs in the formulations. However, current cyclodextrin formulation development strongly depends on trial-and-error in the laboratory, which is time-consuming and high cost. The aim of this research was to compare three modeling approaches (Docking, molecular dynamics (MD), and quantum mechanics (QM)) for cyclodextrin/drug complexation. Ibuprofen was used as a model drug. Binding free energy from three simulation methods was calculated as an important parameter to compare with the experimental results. Docking results from

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5

Easton, Christopher J., Steven J. van Eyk, Stephen F. Lincoln, Bruce L. May, John Papageorgiou, and Michael L. Williams. "A Versatile Synthesis of Linked Cyclodextrins." Australian Journal of Chemistry 50, no. 1 (1997): 9. http://dx.doi.org/10.1071/c96168.

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Reactions of amino-substituted cyclodextrins with bis(3-nitrophenyl) oxalate, malonate, succinate and glutarate, and with diphenyl carbonate, afford a range of linked cyclodextrins. These include α- and β-cyclodextrin dimers, joined by substitution at either C6 or C3, and asymmetric species with a β-cyclodextrin bonded to an a-cyclodextrin and a C3-substituted cyclodextrin attached to a C6-substituted moiety.

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6

Castillo Cruz, Betzaida, Sandra Chinapen Barletta, Bryan G. Ortiz Muñoz, et al. "Effect of Cyclodextrins Formulated in Liposomes and Gold and Selenium Nanoparticles on siRNA Stability in Cell Culture Medium." Pharmaceuticals 17, no. 10 (2024): 1344. http://dx.doi.org/10.3390/ph17101344.

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Background: Encapsulation of siRNA fragments inside liposome vesicles has emerged as an effective method for delivering siRNAs in vitro and in vivo. However, the liposome’s fluid-phospholipid bilayer of liposomes allows siRNA fragments to diffuse out of the liposome, decreasing the dose concentration and therefore the effectiveness of the carrier. We have previously reported that β-cyclodextrins formulated in liposomes help increase the stability of siRNAs in cell culture medium. Here, we continued that study to include α, γ, methyl-β-cyclodextrins and β-cyclodextrin-modified gold and selenium

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7

Lavandier, CD, MP Pelletier та VC Reinsborough. "Surfactant Inclusions by Modified β-Cyclodextrins". Australian Journal of Chemistry 44, № 3 (1991): 457. http://dx.doi.org/10.1071/ch9910457.

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Binding constants for the inclusion of sodium alkane-1-sulfonates (C5-C10, C12) by four modified β- cyclodextrins (2,6-O-dimethyl-β-cyclodextrin, 2,3,6-O-trimethyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin and maltosyl-β-cyclodextrin ) were determined conductimetrically at 25°C. Binding increased with increasing length of the alkyl chain. Generally, the substituted β- cyclodextrins were no more effective as encapsulating agents than ordinary β- cyclodextrin with the persubstituted 2,3,6-O-trimethyl-β-cyclodextrin being the weakest.

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8

Fenyvesi, Ferenc. "Biological Studies on Cyclodextrins." Proceedings 78, no. 1 (2020): 60. http://dx.doi.org/10.3390/iecp2020-08692.

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In recent years, our knowledge of the biological effects of cyclodextrins has grown significantly. Cellular actions of cyclodextrins originate in their ability to form complexes with lipophilic biomolecules. Cyclodextrins can target different types of molecules according to their size, for instance, alpha-cyclodextrins form complexes with phospholipids, while beta-cyclodextrins can bind cholesterol or prostaglandin E2. Due to their interactions with the main membrane constituents, cyclodextrins can affect the barrier function of biological barriers or influence the function of membrane protein

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9

S. Panwar, Vikas, Lokesh Adhikari, Mona Semalty, and Ajay Semalty. "DRUG-CYCLODEXTRIN COMPLEXES: CURRENT STATUS AND RECENT ADVANCEMENTS." INDIAN DRUGS 60, no. 10 (2023): 7–18. http://dx.doi.org/10.53879/id.60.10.12952.

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Cyclodextrins are water-soluble oligosaccharides formed by the action of cyclodextrin glucosyl transferase enzyme (CGTase) on the medium containing starch. Cyclodextrins are proven to be a cost-effective breakthrough in the pharmaceutical industry by formulating them with polymers and drugs to improve the safety, bioavailability, and solubility of APIs. This review describes the current status and advancement of cyclodextrin research in drug delivery. The use of cyclodextrins to improve the solubility and dissolution properties of poor water-soluble products has been reviewed exhaustively with

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10

Yhaya, Firdaus, Andrew M. Gregory, and Martina H. Stenzel. "Polymers with Sugar Buckets - The Attachment of Cyclodextrins onto Polymer Chains." Australian Journal of Chemistry 63, no. 2 (2010): 195. http://dx.doi.org/10.1071/ch09516.

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This Review summarizes the structures obtained when marrying synthetic polymers of varying architectures with cyclodextrins. Polymers with cyclodextrin pendant groups were obtained by directly polymerizing cyclodextrin-based monomers or by postmodification of reactive polymers with cyclodextrins. Star polymers with cyclodextrin as the core with up to 21 arms were usually obtained by using modified cyclodextrins as initiator or controlling agent. Limited reports are available on the synthesis of star polymers by arm-first techniques, which all employed azide-functionalized cyclodextrin and ‘cli

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11

Sivakumar, Ponnurengam M., Shohreh Peimanfard, Ali Zarrabi, Arezoo Khosravi, and Matin Islami. "Cyclodextrin-Based Nanosystems as Drug Carriers for Cancer Therapy." Anti-Cancer Agents in Medicinal Chemistry 20, no. 11 (2020): 1327–39. http://dx.doi.org/10.2174/1871520619666190906160359.

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Background and Objective: Cyclodextrins have been of great interest as excellent candidates for fabricating versatile nano-drug delivery systems due to their commercial availability, easy functionalization, low immunogenicity, biocompatibility and safety. The possibility of reversible inclusion complex formation between cyclodextrins and various guest molecules in association with versatile exclusive properties of cyclodextrins offer a route towards the fabrication of highly sophisticated nanostructures with enormous potential for cancer treatment. Methods and Results: The current review discu

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12

Masoumi, Saeideh, Sahar Amiri, and Seyed Hajir Bahrami. "PCL-based nanofibers containing ibuprofen/cyclodextrins nanocontainers: A potential candidate for drug delivery application." Journal of Industrial Textiles 48, no. 9 (2018): 1420–38. http://dx.doi.org/10.1177/1528083718764910.

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Poor solubility and low dissolution rate of ibuprofen (IBU) in the aqueous gastro-intestinal fluids restrict its application, absorption, distribution, target organ delivery, and bioavailability. For improvement of aqueous solubility of IBU, supramolecular nanocontainers of IBU/cyclodextrin were prepared via formation of inclusion complex between ibuprofen and cyclodextrins (α-cyclodextrin and β-cyclodextrin) at various conditions (at room temperature at 25℃ and under sonic energy). The formation of inclusion complex between IBU and cyclodextrins can be confirmed by hydrogen nuclear magnetic r

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13

Ji, Xin-Yu, Yi-Xuan Zou, Han-Fang Lei, et al. "Advances in Cyclodextrins and Their Derivatives in Nano-Delivery Systems." Pharmaceutics 16, no. 8 (2024): 1054. http://dx.doi.org/10.3390/pharmaceutics16081054.

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The diversity of cyclodextrins and their derivatives is increasing with continuous research. In addition to monomolecular cyclodextrins with different branched chains, cyclodextrin-based polymers have emerged. The aim of this review is to summarize these innovations, with a special focus on the study of applications of cyclodextrins and their derivatives in nano-delivery systems. The areas covered include nanospheres, nano-sponges, nanogels, cyclodextrin metal–organic frameworks, liposomes, and emulsions, providing a comprehensive and in-depth understanding of the design and development of nan

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14

Musuc, Adina Magdalena. "Cyclodextrins: Advances in Chemistry, Toxicology, and Multifaceted Applications." Molecules 29, no. 22 (2024): 5319. http://dx.doi.org/10.3390/molecules29225319.

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Cyclodextrins (CDs) have garnered significant attention in various scientific and industrial fields due to their unique ability to form inclusion complexes with a wide range of guest molecules. This review comprehensively explores the latest advancements in cyclodextrin chemistry, focusing on the synthesis and characterization of cyclodextrin derivatives and their inclusion complexes. This review examines the biological activities of cyclodextrins, highlighting their pharmacological properties and pharmacokinetics, and discussing their promising applications in drug delivery systems. Furthermo

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15

Prior, Marguerite, Sylvain Lehmann, Man-Sun Sy, Brendan Molloy, and Hilary E. M. McMahon. "Cyclodextrins Inhibit Replication of Scrapie Prion Protein in Cell Culture." Journal of Virology 81, no. 20 (2007): 11195–207. http://dx.doi.org/10.1128/jvi.02559-06.

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ABSTRACT Prion diseases are fatal neurodegenerative disorders that are caused by the conversion of a normal host-encoded protein, PrPC, to an abnormal, disease-causing form, PrPSc. This paper reports that cyclodextrins have the ability to reduce the pathogenic isoform of the prion protein PrPSc to undetectable levels in scrapie-infected neuroblastoma cells. Beta-cyclodextrin removed PrPSc from the cells at a concentration of 500 μM following 2 weeks of treatment. Structure activity studies revealed that antiprion activity was dependent on the size of the cyclodextrin. The half-maximal inhibito

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16

Gatiatulin, Askar K., Ivan A. Grishin, Aleksey V. Buzyurov, Timur A. Mukhametzyanov, Marat A. Ziganshin, and Valery V. Gorbatchuk. "Determination of Melting Parameters of Cyclodextrins Using Fast Scanning Calorimetry." International Journal of Molecular Sciences 23, no. 21 (2022): 13120. http://dx.doi.org/10.3390/ijms232113120.

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The first evidence of native cyclodextrins fusion was registered using fast scanning calorimetry (FSC) with heating rates up to 40,000 K s−1. The endothermal effects, detected at low heating rates, correspond to the decomposition processes. Upon the increase of the heating rate the onset of these effects shifts to higher temperatures, reaching a limiting value at high heating rates. The limiting temperatures were identified as the melting points of α-, β- and γ-cyclodextrins, as the decomposition processes are suppressed at high heating rates. For γ-cyclodextrin the fusion enthalpy was measure

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17

Braga, Susana Santos. "Cyclodextrins as Multi-Functional Ingredients in Dentistry." Pharmaceutics 15, no. 9 (2023): 2251. http://dx.doi.org/10.3390/pharmaceutics15092251.

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Cyclodextrins are present in a variety of oral hygiene compositions. The present work describes the role of cyclodextrins in several toothpastes and mouthwashes that are already available in the market, as well as their prospective use in other applications as investigated in studies in the literature. Moreover, cyclodextrins are under study for the development of materials used in various techniques of dental repair, such as fillings, cements and binders therein. Their role in each of the innovative materials is presented. Finally, the prospect of the use of cyclodextrin-based delivery system

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18

Székely-Szentmiklósi, Blanka, and B. Tőkés. "Study of Cyclodextrin/Fluoroquinolone Inclusion Complexes by Capillary Electrophoresis." Acta Medica Marisiensis 59, no. 2 (2013): 107–10. http://dx.doi.org/10.2478/amma-2013-0026.

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AbstractIntroduction: In the present work we evaluated the complexation role of cyclodextrins toward fluoroquinolones in an attempt to assess their potential as new formulation additives for more efficient fluoroquinolone delivery and as selectors in capillary electrophoresis.Material and method: Guest-host interactions of two second generation quinolones, ciprofloxacin and norfloxacin with four cyclodextrins, beta-cyclodextrin (β-CD), gamma-cyclodextrin (γ-CD) and two beta-cyclodextrin derivatives, 2-hydroxypropyl beta-cyclodextrin (HP-β-CD) and randomly methylated beta-cyclodextrin (RAMEB),

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19

Braga, Susana Santos, Karyna Lysenko, Firas El-Saleh, and Filipe A. Almeida Paz. "Cyclodextrin-Efavirenz Complexes Investigated by Solid State and Solubility Studies." Proceedings 78, no. 1 (2020): 15. http://dx.doi.org/10.3390/iecp2020-08690.

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This short paper investigates the solubilizing ability of various cyclodextrins with efavirenz as well as the formation of solid inclusion complexes of efavirenz with β-CD and γ-CD. (1) Background: Efavirenz is a non-nucleoside reverse transcriptase inhibitor used as first-line treatment for adult and pediatric human immunodeficiency virus type 1 infection (HIV-1). Belonging to class II of Biopharmaceutical Classification System (BCS), efavirenz is poorly water-soluble. Inclusion into cyclodextrins is a possible strategy for increasing its solubility. (2) Methods: Solubility modulation was inv

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20

Wang, Lei, Xuguo Duan та Jing Wu. "Enhancing the α-Cyclodextrin Specificity of Cyclodextrin Glycosyltransferase from Paenibacillus macerans by Mutagenesis Masking Subsite −7". Applied and Environmental Microbiology 82, № 8 (2016): 2247–55. http://dx.doi.org/10.1128/aem.03535-15.

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ABSTRACTCyclodextrin glycosyltransferases (CGTases) (EC 2.4.1.19) catalyze the conversion of starch or starch derivates into mixtures of α-, β-, and γ-cyclodextrins. Because time-consuming and expensive purification procedures hinder the widespread application of single-ingredient cyclodextrins, enzymes with enhanced specificity are needed. In this study, we tested the hypothesis that the α-cyclodextrin selectivity ofPaenibacillus maceransα-CGTase could be augmented by masking subsite −7 of the active site, blocking the formation of larger cyclodextrins, particularly β-cyclodextrin. Five singl

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21

Healy, Bronach, Tian Yu, Daniele C. da Silva Alves, Cynthia Okeke, and Carmel B. Breslin. "Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors." Materials 14, no. 7 (2021): 1668. http://dx.doi.org/10.3390/ma14071668.

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Supramolecular chemistry, although focused mainly on noncovalent intermolecular and intramolecular interactions, which are considerably weaker than covalent interactions, can be employed to fabricate sensors with a remarkable affinity for a target analyte. In this review the development of cyclodextrin-based electrochemical sensors is described and discussed. Following a short introduction to the general properties of cyclodextrins and their ability to form inclusion complexes, the cyclodextrin-based sensors are introduced. This includes the combination of cyclodextrins with reduced graphene o

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22

Durand, Amaury, David Mathiron, Sébastien Rigaud, Florence Djedaini-Pilard та Frédéric Marçon. "Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment". Pharmaceutics 15, № 12 (2023): 2794. http://dx.doi.org/10.3390/pharmaceutics15122794.

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This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution. This approach may enhance the effectiveness of mefloquine, a drug which can be used for malaria prophylaxis and treatment in children. Mefloquine hydrochloride’s solubility was assessed in different buffer solutions, and its quantification was achieved through high-performance liquid chromatography. The complexation efficiency with cyclodextrins was evaluated, and nuclear magnetic resonance (NMR) methods were employed to determine the interactions

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Murai, Hisao, Yoshinori Yamamoto, and Yasumasa J. I'Haya. "Time-resolved ESR study on photochemical formation of radical pair in cyclodextrin cavities." Canadian Journal of Chemistry 69, no. 11 (1991): 1643–48. http://dx.doi.org/10.1139/v91-241.

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The photoreduction of xanthone with diethylaniline in cyclodextrin cavities was studied at 77 K and room temperature by a time-resolved ESR technique. The radical pair observed in β- and γ-cyclodextrins showed inverted spin polarization compared to that of precursor excited triplet xanthone. This result is rationalized by taking account of the fixed orientation of the radical ion pair in the cyclodextrins. Frozen aqueous solutions and dried powder-like samples provided similar results. The spectrum of the radical pair was also detected in an aqueous solution of β-cyclodextrin at room temperatu

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Raut, Sushil Y., Alekhya S. N. Manne, Guruprasad Kalthur, Sanyog Jain, and Srinivas Mutalik. "Cyclodextrins as Carriers in Targeted Delivery of Therapeutic Agents: Focused Review on Traditional and Inimitable Applications." Current Pharmaceutical Design 25, no. 4 (2019): 444–54. http://dx.doi.org/10.2174/1381612825666190306163602.

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The objective of the article is to provide a comprehensive review on the application of cyclodextrin complexation in the delivery of drugs, bioactive molecules or macromolecules, with more emphasis on targeted drug delivery. Classically the cyclodextrins have been considered only as a means of improving the solubility of drugs; however, many attempts have been made to use cyclodextrins as drug delivery carriers. The cyclodextrin surface can be modified with various ligands for active targeting of drugs. It can also be passively targeted through various triggering mechanisms like thermal, magne

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Easton, CJ, S. Kassara, SF Lincoln, and BL May. "Amino Substituents as a Probe of Reactions of Phenyl Acetates With Cyclodextrins." Australian Journal of Chemistry 48, no. 2 (1995): 269. http://dx.doi.org/10.1071/ch9950269.

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The effects of α- and β- cyclodextrin and 6A-amino-6A-deoxy-α- and -β- cyclodextrin on the rates of reactions of m- and p-nitrophenyl acetate, in borate buffer at pH 10.0 and 298.2 K, show that the amino substituents of the modified cyclodextrins have only a modest influence on the dissociation constants of the complexes formed with each ester and the first-order rate constants for the reactions of complexed m-nitrophenyl acetate. By contrast, the amino substituents significantly increase the rate constants for the reactions of complexes of p- nitrophenyl acetate. These results indicate that o

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Vranić, Edina, and Alija Uzunović. "Dissolution Studies of Physical Mixtures of Indomethacin with Alpha- and Gamma-Cyclodextrins." Bosnian Journal of Basic Medical Sciences 10, no. 3 (2010): 197–203. http://dx.doi.org/10.17305/bjbms.2010.2685.

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Oral administration of indomethacin has been limited by its poor water solubility. Cyclodextrins have been recognized as potential candidates to overcome the poor solubility of indomethacin through the formation of inclusion complexes.The aim of our study was to compare the dissolution profiles of pure indomethacin and its mixtures with α- and γ-cyclodextrins The inclusion complexes of indomethacin with α- and γ-cyclodextrins were prepared by direct mixing in dissolution vessel. Fixed volumes of the dissolution medium were withdrawn at 0,5; 1 and 4 hours. Dissolution tests were performed on th

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Cabal, Jiří. "Hydrolytic Reactions of Methylfluorophosphonates with Cyclodextrins." Collection of Czechoslovak Chemical Communications 60, no. 7 (1995): 1162–69. http://dx.doi.org/10.1135/cccc19951162.

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Reactions of three methylfluorophosphonates (isopropyl, 1,2,2-trimethylpropyl, and cyclohexyl) with α-, β- and γ-cyclodextrins were investigated. The cyclodextrins were found to react with stereoisomers of the methylfluorophosphonates at different rates depending on the location of the substituents at the phosphorus atom. The dependence of the rate increase on cyclodextrin concentration showed a saturation effect. The reactivity of the inclusion complexes of the cyclodextrins with the methylfluorophosphonates depended on the size of the alkyl part of the phosphonate molecule as well as on the

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Easton, Christopher J., Stephen F. Lincoln, Bruce L. May, and John Papageorgiou. "Reactions of Amino-Substituted Cyclodextrins with 2-Arylpropanoic Acid Derivatives." Australian Journal of Chemistry 50, no. 5 (1997): 451. http://dx.doi.org/10.1071/c97034.

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Reactions of 6A-amino-6A-deoxy-β-cyclodextrin and 3A-amino-3A-deoxy-(2AS,3AS)-β-cyclodextrin with the 3-nitrophenyl esters of 2-phenylpropanoic acid and Ibuprofen occur with only low diastereoselectivity, to afford the corresponding arylpropanamido-substituted cyclodextrins. These amides are also formed by decarboxylation of corresponding malonates, again with only low diastereoselectivity. The n.m.r. spectra of the amido-substituted cyclodextrins indicate that the aryl substituent is included within the cyclodextrin annulus at low temperature, but becomes dissociated from the cavity as the te

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Belyakova, L. A. "Encapsulation of benzene carboxylic acids using cyclodextrins." Himia, Fizika ta Tehnologia Poverhni 12, no. 1 (2021): 40–51. http://dx.doi.org/10.15407/hftp12.01.040.

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The encapsulation of medicinal substances in various polymers is a common way to increase their thermal, hydrolytic, and chemical stability. However, the bioavailability of the encapsulated drugs decreases. The solution to this important problem can be the preparation of nanocapsules of medicinal substances using complexing agents, for example, cyclodextrins. The purpose of this work is to study the possibility of encapsulation of benzoic, salicylic, and β-resorcylic acids using α- and β-cyclodextrins. The interaction of benzene carboxylic acids with cyclodextrins in aqueous solutions at 20–30

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Kazlauskaite, Jurga Andreja, Liudas Ivanauskas, and Jurga Bernatoniene. "Cyclodextrin-Assisted Extraction Method as a Green Alternative to Increase the Isoflavone Yield from Trifolium pratensis L. Extract." Pharmaceutics 13, no. 5 (2021): 620. http://dx.doi.org/10.3390/pharmaceutics13050620.

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Trifolium pratense L. is receiving increasing attention due to the isoflavones it contains, which have been studied for their benefits to human health. A common problem with isoflavone aglycones is a rather low water solubility and limited pharmaceutical applications. The use of excipients, such as cyclodextrins in the production of isoflavone rich extracts, could become one of the new strategies for the extraction of target compounds. The aim of this study was to evaluate an eco-friendly method using the effects of α-, β- and γ-cyclodextrins for isoflavone solubilization in plant extracts in

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Yannakopoulou, Konstantina, Laszlo Jicsinszky, Crysie Aggelidou та ін. "Symmetry Requirements for Effective Blocking of Pore-Forming Toxins: Comparative Study with α-, β-, and γ-Cyclodextrin Derivatives". Antimicrobial Agents and Chemotherapy 55, № 7 (2011): 3594–97. http://dx.doi.org/10.1128/aac.01764-10.

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ABSTRACTWe compared the abilities of structurally related cationic cyclodextrins to inhibitBacillus anthracislethal toxin andStaphylococcus aureusα-hemolysin. We found that both β- and γ-cyclodextrin derivatives effectively inhibited anthrax toxin action by blocking the transmembrane oligomeric pores formed by the protective antigen (PA) subunit of the toxin, whereas α-cyclodextrins were ineffective. In contrast, α-hemolysin was selectively blocked only by β-cyclodextrin derivatives, demonstrating that both symmetry and size of the inhibitor and the pore are important.

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Kazlauskaite, Jurga Andreja, Liudas Ivanauskas, Mindaugas Marksa, and Jurga Bernatoniene. "The Effect of Traditional and Cyclodextrin-Assisted Extraction Methods on Trifolium pratense L. (Red Clover) Extracts Antioxidant Potential." Antioxidants 11, no. 2 (2022): 435. http://dx.doi.org/10.3390/antiox11020435.

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Red clover is the subject of numerous studies because of its antioxidant properties, the positive influence of isoflavones on the health, and its potential use in the prevention and treatment of chronic diseases. The right excipients, such as cyclodextrins, can increase the profile of valuable phenolic compounds in extraction media to obtain rich in antioxidants, extracts that can be used in nutraceuticals production. The aim of this study was to investigate and compare the total phenolic content, flavonoid content, and antioxidant activity of red clover aerial parts, aqueous and ethanolic ext

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Delyagina, E. S., A. A. Garibyan та I. V. Terekhova. "Comparative Analysis of the Effect of Native and Polymeric β-Cyclodextrins on the Solubility and Membrane Permeability of Baricitinib". Журнал физической химии 97, № 8 (2023): 1218–24. http://dx.doi.org/10.31857/s0044453723080046.

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A study is performed of the effect native and polymeric β-cyclodextrins have on the solubility and membrane permeability of baricitinib, a new generation immunomodulator. It is found that native and polymeric β-cyclodextrins exhibit the same solubilizing effect in relation to baricitinib, while their effect on the membrane permeability of the drug differs. The increased solubility of baricitinib is due to the formation of inclusion complexes that have the same stability but are enthalpy-entropy stabilized in native β-cyclodextrin and enthalpy stabilized in polymeric β-cyclodextrin. The effect

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34

Li, Shujing, Li Yuan, Bing Zhang, Wei Zhou, Xinrui Wang та Dongsheng Bai. "Photostability and antioxidant activity studies on the inclusion complexes of trans-polydatin with β-cyclodextrin and derivatives". RSC Advances 8, № 46 (2018): 25941–48. http://dx.doi.org/10.1039/c8ra04778b.

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35

Rusznyák, Ágnes, Mercédesz Palicskó, Milo Malanga, et al. "Cellular Effects of Cyclodextrins: Studies on HeLa Cells." Molecules 27, no. 5 (2022): 1589. http://dx.doi.org/10.3390/molecules27051589.

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Abstract (sommario):

Cyclodextrins are high molecular weight, hydrophilic, cyclic, non-reducing oligosaccharides, applied as excipients for the improvement of the solubility and permeability of insoluble active pharmaceutical ingredients. On the other hand, beta-cyclodextrins are used as cholesterol sequestering agents in life sciences. Recently, we demonstrated the cellular internalization and intracellular effects of cyclodextrins on Caco-2 cells. In this study, we aimed to further investigate the endocytosis of (2-hydroxylpropyl)-beta-(HPBCD) and random methylated-beta-cyclodextrin (RAMEB) to test their cytotox

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36

Musilová, Lenka, Aleš Mráček, Eduarda F. G. Azevedo та ін. "Interactions between Sodium Hyaluronate and β-Cyclodextrin as Seen by Transport Properties". International Journal of Molecular Sciences 24, № 3 (2023): 2889. http://dx.doi.org/10.3390/ijms24032889.

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Knowledge of mass transport parameters, diffusion, and viscosity of hyaluronic acid (HA) in the presence of cyclodextrins is of considerable importance for areas such as food packaging and drug delivery, among others. Despite a number of studies investigating the functionalization of HA or the corresponding sodium salt by cyclodextrins, only a few studies have reported the effect of cyclodextrins on the mass transport of HA in the presence of these oligosaccharides. Here, we report the tracer binary and ternary interdiffusion coefficients of sodium hyaluronate (NaHy) in water and aqueous β-cyc

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Rassu, Giovanna, Silvia Fancello, Marta Roldo, et al. "Investigation of Cytotoxicity and Cell Uptake of Cationic Beta-Cyclodextrins as Valid Tools in Nasal Delivery." Pharmaceutics 12, no. 7 (2020): 658. http://dx.doi.org/10.3390/pharmaceutics12070658.

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Abstract (sommario):

Cyclodextrin polymers have high applicability in pharmaceutical formulations due to better biocompatibility, solubility enhancement, loading capacity and controlled drug release than their parent, cyclodextrins. The cytotoxicity and cell uptake of new cationic beta-cyclodextrin monomers and polymers were evaluated as suitable materials for nasal formulations and their protective effects on cells exposed to hydrogen peroxide were studied. PC12 and CACO-2 cells were selected as the neuronal- and epithelial-type cells, respectively, to mimic the structure of respiratory and olfactory epithelia of

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38

Rusznyák, Ágnes, Milo Malanga, Éva Fenyvesi, et al. "Investigation of the Cellular Effects of Beta- Cyclodextrin Derivatives on Caco-2 Intestinal Epithelial Cells." Pharmaceutics 13, no. 2 (2021): 157. http://dx.doi.org/10.3390/pharmaceutics13020157.

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Abstract (sommario):

Cyclodextrins are widely used excipients for increasing water-solubility, delivery and bioavailability of lipophilic drugs. By using fluorescent cyclodextrin derivatives, we showed previously that cyclodextrins are able to enter Caco-2 intestinal cells by endocytosis, but the influence of different fluorescent labeling on the same cyclodextrin derivative has not been studied. The consequences of the cellular internalization of cyclodextrins have not been revealed yet either. The aims of this study were to compare the cellular internalization of fluorescein- and rhodamine-labeled (2-hydroxyprop

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Nazli, Adila, Milo Malanga, Tamás Sohajda, and Szabolcs Béni. "Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery." Pharmaceutics 17, no. 1 (2025): 81. https://doi.org/10.3390/pharmaceutics17010081.

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Abstract (sommario):

Cyclodextrins can serve as carriers for various payloads, utilizing their capacity to form unique host–guest inclusion complexes within their cavity and their versatile surface functionalization. Recently, cationic cyclodextrins have gained considerable attention, as they can improve drug permeability across negatively charged cell membranes and efficiently condense negatively charged nucleic acid due to electrostatic interactions. This review focuses on state-of-the-art and recent advances in the construction of cationic cyclodextrin-based delivery systems. First, we identified different cati

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40

Lemli, Beáta, Péter Vilmányi, Eszter Fliszár-Nyúl, et al. "Testing Serum Albumins and Cyclodextrins as Potential Binders of the Mycotoxin Metabolites Alternariol-3-Sulfate, Alternariol-9-Monomethylether and Alternariol-9-Monomethylether-3-Sulfate." International Journal of Molecular Sciences 23, no. 22 (2022): 14353. http://dx.doi.org/10.3390/ijms232214353.

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Abstract (sommario):

Alternaria mycotoxins, including alternariol (AOH), alternariol-9-monomethylether (AME), and their masked/modified derivatives (e.g., sulfates or glycosides), are common food contaminants. Their acute toxicity is relatively low, while chronic exposure can lead to the development of adverse health effects. Masked/modified metabolites can probably release the more toxic parent mycotoxin due to their enzymatic hydrolysis in the intestines. Previously, we demonstrated the complex formation of AOH with serum albumins and cyclodextrins; these interactions were successfully applied for the extraction

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41

Solomon, Cristina, Valentina Anuța, Iulian Sarbu, et al. "Enhancing the Drug Release and Physicochemical Properties of Rivaroxaban via Cyclodextrin Complexation: A Comprehensive Analytical Approach." Pharmaceuticals 18, no. 6 (2025): 761. https://doi.org/10.3390/ph18060761.

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Abstract (sommario):

Background/Objectives: Rivaroxaban, an oral anticoagulant, shows poor aqueous solubility, posing significant challenges to its bioavailability and therapeutic efficiency. The present study investigates the improvement of rivaroxaban’s solubility through the formation of different inclusion complexes with three cyclodextrin derivatives, such as β-cyclodextrin (β-CD), methyl-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD) prepared by lyophilization in order to stabilize the complexes and improve dissolution characteristics of rivaroxaban. Methods: The physicochemical propert

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42

ZHEKOVA, BORIANA Y., and VESELIN S. STANCHEV. "Reaction Conditions for Maximal Cyclodextrin Production by Cyclodextrin Glucanotransferase from Bacillus megaterium." Polish Journal of Microbiology 60, no. 2 (2011): 113–18. http://dx.doi.org/10.33073/pjm-2011-015.

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Abstract (sommario):

The effect of the reaction conditions (substrate concentration, enzyme dosage, and pH) on cyclodextrin production by cyclodextrin glucanotransferase from Bacillus megaterium was investigated by applying mathematical modeling methods. Adequate models were developed and they were used for determination of the optimal conditions for maximal formation of beta-cyclodextrins at minimal concentrations of a- and gamma-cydclodextrins. The main factor affecting the ratio of the products was pH of the reaction mixture. At pH 9 the enzyme formed mainly beta- and y-cyclodextrins and the ratio a:beta:gamma

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Jessen, Cecilie Høgfeldt, Jesper Bendix, Theis Brock Nannestad, et al. "CO₂ complexation with cyclodextrins." Beilstein Journal of Organic Chemistry 19 (July 17, 2023): 1021–27. http://dx.doi.org/10.3762/bjoc.19.78.

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Abstract (sommario):

Carbon dioxide (CO2) emissions from industrial processes, power generation, and transportation contribute significantly to global warming and climate change. Carbon capture and storage (CCS) technologies are essential to reduce these emissions and mitigate the effects of climate change. Cyclodextrins (CDs), cyclic oligosaccharides, are studied as potential CO2 capture agents due to their unique molecular structures and high selectivity towards CO2. In this paper we have investigated binding efficiency of a number of cyclodextrins towards CO2. It is found that the crystal structure of α-cyclode

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44

Dumanski, Paul G., Christopher J. Easton, Stephen F. Lincoln, and Jamie S. Simpson. "Effect of Cyclodextrins on Electrophilic Aromatic Bromination in Aqueous Solution." Australian Journal of Chemistry 56, no. 11 (2003): 1107. http://dx.doi.org/10.1071/ch03102.

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Abstract (sommario):

Cyclodextrins act as molecular reactors to change the ratios of the products of reactions of anisole, acetanilide, 3-methylanisole, and 3-methylacetanilide with pyridinium dichlorobromate. With anisole and acetanilide, bromination at the para position is favoured over ortho substitution, and the effect is greatest with α-cyclodextrin. In the reactions of the methylanisole and methylacetanilide, the cyclodextrins afford higher yields of monobrominated products and less of the di- and tribromides, and β-cyclodextrin has the greatest effect. These outcomes can be attributed to inclusion of the su

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45

Kean, Suzanna D., Christopher J. Easton та Stephen F. Lincoln. "Metallo-β-cyclodextrins of 6A-(2-(2-(2-Aminoethylamino)-ethylamino)ethylamino)-6A-deoxy-β-cyclodextrin and 6A-Deoxy-6A-(1,4,7,10-tetraazacyclododecan-1-yl)-β-cyclodextrin: Their Formation and Complexation of (R)- and (S)-Tryptophan and Tryptophanate in Aqueous Solution". Australian Journal of Chemistry 53, № 5 (2000): 375. http://dx.doi.org/10.1071/ch00052.

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Abstract (sommario):

The binary metallo-β-cyclodextrins formed by 6A-(2-(2-(2-aminoethylamino)ethylamino)ethylamino)-6A-deoxy-β-cyclodextrin, [M(βCDtrien)]2+, where M2+ = Ni2+, Cu2+ and Zn2+, are characterized by log(K/dm3 mol-1) = 11.500.02, 10.700.07 and 9.400.01, respectively, in aqueous solution at 298.2 K and I = 0.1 mol dm-3 (NaClO4), where K is the stability constant. For those formed by 6A-deoxy-6A-(1,4,7,10-tetraazacyclododecan-1-yl)-β-cyclodextrin, [M(βCDcyclen)]2+, where M2+ = Cu2+ and Zn2+, log(K/dm3 mol-1) = 13.610.02 and 11.620.04, respectively. The ternary metallo-β-cyclodextrins formed by [M(βCDtri

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46

Rajput, Kiransinh N., Kamlesh C. Patel та Ujjval B. Trivedi. "β-Cyclodextrin Production by Cyclodextrin Glucanotransferase from an Alkaliphile Microbacterium terrae KNR 9 Using Different Starch Substrates". Biotechnology Research International 2016 (25 серпня 2016): 1–7. http://dx.doi.org/10.1155/2016/2034359.

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Abstract (sommario):

Cyclodextrin glucanotransferase (CGTase, EC 2.4.1.19) is an important member of α-amylase family which can degrade the starch and produce cyclodextrins (CDs) as a result of intramolecular transglycosylation (cyclization). β-Cyclodextrin production was carried out using the purified CGTase enzyme from an alkaliphile Microbacterium terrae KNR 9 with different starches in raw as well as gelatinized form. Cyclodextrin production was confirmed using thin layer chromatography. Six different starch substrates, namely, soluble starch, potato starch, sago starch, corn starch, corn flour, and rice flour

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47

Kontogiannidou, Eleni, Martina Ferrari, Asteria-Danai Deligianni, et al. "In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery." Pharmaceutics 11, no. 8 (2019): 398. http://dx.doi.org/10.3390/pharmaceutics11080398.

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Abstract (sommario):

In the current study, the development of mucoadhesive tablets for buccal delivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes with piroxicam and cyclodextrins (β-cyclodextrin (β-CD), methylated-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD)) were prepared by the co-evaporation method. All formulations were characterized by means of differential scanning calorimetry, infrared spectroscopy and powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by direct compression using chitosan as mucoadhesive polymer. The

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48

Poulson, Benjamin Gabriel, Qana A. Alsulami, Abeer Sharfalddin, et al. "Cyclodextrins: Structural, Chemical, and Physical Properties, and Applications." Polysaccharides 3, no. 1 (2021): 1–31. http://dx.doi.org/10.3390/polysaccharides3010001.

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Abstract (sommario):

Due to their unique structural, physical and chemical properties, cyclodextrins and their derivatives have been of great interest to scientists and researchers in both academia and industry for over a century. Many of the industrial applications of cyclodextrins have arisen from their ability to encapsulate, either partially or fully, other molecules, especially organic compounds. Cyclodextrins are non-toxic oligopolymers of glucose that help to increase the solubility of organic compounds with poor aqueous solubility, can mask odors from foul-smelling compounds, and have been widely studied i

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Braga, Susana Santos, Jéssica S. Barbosa, Nádia E. Santos, Firas El-Saleh, and Filipe A. Almeida Paz. "Cyclodextrins in Antiviral Therapeutics and Vaccines." Pharmaceutics 13, no. 3 (2021): 409. http://dx.doi.org/10.3390/pharmaceutics13030409.

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Abstract (sommario):

The present review describes the various roles of cyclodextrins (CDs) in vaccines against viruses and in antiviral therapeutics. The first section describes the most commonly studied application of cyclodextrins—solubilisation and stabilisation of antiviral drugs; some examples also refer to their beneficial taste-masking activity. The second part of the review describes the role of cyclodextrins in antiviral vaccine development and stabilisation, where they are employed as adjuvants and cryopreserving agents. In addition, cyclodextrin-based polymers as delivery systems for mRNA are currently

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50

Varan, Gamze. "Cyclodextrin in Vaccines: Enhancing Efficacy and Stability." Future Pharmacology 3, no. 3 (2023): 597–611. http://dx.doi.org/10.3390/futurepharmacol3030038.

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Abstract (sommario):

Cyclodextrins, a family of cyclic oligosaccharides, have received considerable interest in the field of pharmaceuticals due to their unique molecular structure and versatile properties. In the context of vaccines, cyclodextrins can effectively encapsulate antigens, ensuring their protection from degradation and improving their immunogenicity. Cyclodextrins offer stability advantages to vaccines by preventing the degradation of labile vaccine components during storage and transportation. Furthermore, cyclodextrins can serve as adjuvants, potentiating the immune response triggered by vaccines. T

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