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Tesi sul tema "Cyclophosphamide"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Levy, Karine. "Toxicité du cyclophosphamide." Paris 5, 1993. http://www.theses.fr/1993PA05P156.

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2

Afsharian, Parvaneh. "Optimization of cyclophosphamide therapy based on pharmacogenetics /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-997-1/.

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3

Yule, S. M. "The clinical pharmacology of cyclophosphamide in children." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309831.

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4

Chanellière, Christiane. "Intérêt de l'utilisation du cyclophosphamide dans le traitement des pemphigoi͏̈des bulleuses et des pemphigus." Montpellier 1, 1989. http://www.theses.fr/1989MON11064.

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5

Belfayol-Pisanté, Laurence. "Evaluation d'un index prédictif de l'apparition des effets secondaires liés au traitement par le cyclophosphamide chez des patients atteints de vascularites et de collagénoses." Paris 5, 2000. http://www.theses.fr/2000PA05P629.

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Abstract (sommario):

Le cyclophosphamide est un agent anticancéreux et immunosuppresseur utilisé aussi bien dans le traitement des affections malignes que des maladies systémiques. Si les études pharmacocinétiques ont été largement décrites chez les patients traités par le cyclophosphamide seul ou en association pour ses propriétés antinéoplasiques, aucune n'aborde la pharmacocinétique du cyclophosphamide et de son métabolite, le 4-hydroxycyclophosphamide/aldophosphamide, chez les patients atteints de vascularites ou de collagénoses. En raison de la toxicité liée au traitement par le cyclophosphamide chez ces suje

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6

Lo, Kwun-hang Kenny. "Effects of cyclophosphamide on ulcer in rat stomachs /." View the Table of Contents & Abstract, 2004. http://sunzi.lib.hku.hk/hkuto/record/B30708825.

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7

盧冠恆 and Kwun-hang Kenny Lo. "Effects of cyclophosphamide on ulcer in rat stomachs." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B45010158.

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8

Maynard-Faure, Patricia. "Synthèse d'analogues bicycliques préactives du cyclophosphamide et de l'aldophosphamide." Lyon 1, 1997. http://www.theses.fr/1997LYO10268.

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Ce memoire de these concerne l'etude de voies de synthese de nouveaux analogues du cyclophosphamide et de l'aldophosphamide. Apres avoir rappele la place du cyclophosphamide, agent cancerostatique le plus utilise en clinique humaine, dans l'arsenal des medicaments anticancereux, nous avons passe en revue les nombreux analogues deja synthetises en vue d'obtenir des composes a index therapeutique plus eleve. Nous presentons ensuite des voies de syntheses possibles pour des derives bicycliques preactives cibles ne necessitant pas d'activation biologique. Ce travail a permis de completer l'etude d

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9

Lu, Hong. "Pharmacokinetic and drug metabolism studies of cyclophosphamide and ifosfamide /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu148795015360318.

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10

Li, Zhaoyang. "DNA alkylation by active metabolites of Cyclophosphamide and Ifosfamide /." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488192960169091.

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11

Klinger, Mary Beth. "Neuroplasticity of Micturition Reflex Pathways with Cyclophosphamide-Induced Cystitis." ScholarWorks @ UVM, 2008. http://library.uvm.edu/dspace/bitstream/123456789/173/1/marybethklingerfinal.pdf.

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12

Ren, Song. "Metabolism of cyclophosphamide : implications for hematopoietic stem cell transplantation /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7968.

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13

Sarkar, Anish Ali. "Inflammation Of The Taste Sensory System: Cyclophosphamide And Amifostine." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1168.

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Abstract (sommario):

Chemotherapeutics are used extensively to treat cancer patients and often induce adverse effects, including taste dysfunctions. Disturbances in taste are detrimental to the overall well-being of cancer patients, causing malnutrition and weight loss that aggravate their condition even further. Inflammation due to an infection of the taste sensory system as previously shown, has detrimental effects on the taste sensation. Our study focused on if chemotherapy induced an inflammatory response in the taste buds using cyclophosphamide (CYP), a pro-drug. Once metabolized by the P450 enzyme complex, i

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14

Henin, Coralie. "Potentialisation de la réponse immunitaire anti-tumorale par le cyclophosphamide." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/252210.

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À ce jour, il est connu que le succès des traitements chimiothérapeutiques, outre l’effet cytotoxique direct sur les cellules tumorales, repose sur la contribution du système immunitaire. Nos travaux de recherche montrent que le traitement au cyclophosphamide de souris DBA/2 porteuses du mastocytome P815 induit le rejet de la tumeur, ainsi qu’une protection à long terme, de façon dépendante de la présence des lymphocytes T CD4+ et CD8+. De plus, le rejet du mastocytome P815 corrèle avec une augmentation de l’infiltration au sein de la tumeur de lymphocytes T CD8+ spécifiques d’un antigène muté

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15

Delgado, Zambrano Luis Fernando. "Bioréacteur à membrane externe pour le traitement d'effluents contenant des médicaments anticancéreux : élimination et influence du cyclophosphamide et de ses principaux métabolites sur le procédé." Thesis, Toulouse, INPT, 2009. http://www.theses.fr/2009INPT005G/document.

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La problématique concernant la présence et les risques potentiels liés aux micropolluants dans l'environnement est devenue une préoccupation d'actualité. Aujourd'hui, les stations d'épuration ne sont pas en mesure de traiter de manière adéquate ce nouveau type de pollution. Dans le cadre de cette thèse, l'application de la technologie des bioréacteurs à membrane a été envisagée afin d'évaluer leur potentiel pour la dégradation d'un médicament anticancéreux : le cyclophosphamide (CP). Les objectifs de cette étude sont d'une part évaluer le potentiel des bioréacteurs à membrane pour la dégradati

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16

Cárcano, Flavio Mavignier [UNESP]. "Quimioterapia à base de ciclofosfamida metronômica no tratamento de pacientes com câncer de próstata resistente à castração." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/88070.

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Made available in DSpace on 2014-06-11T19:23:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-03-14Bitstream added on 2014-06-13T19:49:50Z : No. of bitstreams: 1 carcano_fm_me_botfm.pdf: 463339 bytes, checksum: 1e76f6dc55ab48a9f3d597694700438f (MD5)<br>Fundação Pio Xii - Barretos<br>O câncer de próstata é o sexto tipo de câncer mais comum no mundo e cerca de três quartos dos casos ocorrem a partir dos 65 anos. O tratamento paliativo inicial para doença avançada contempla a castração, mas invariavelmente, metástases e resistência é desenvolvida em algum momento, quando então a quimio

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17

Brain, Étienne. "Les alkylants oxazaphosphorines (cyclophosphamide et ifosfamide), la modulation de leur métabolisme hépatique et de leur pharmacocinétique." Paris 5, 2005. http://www.theses.fr/2005PA05S018.

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Le métabolisme hépatique des oxazaphosphorines cyclophosphamide et ifosfamide via les cytochromes P450 oscille entre une voie d'activation (4-hydroxylation) et une voie de toxification (N-déchloroéthylation). A l'aide d'inducteurs/inhibiteurs spécifiques des cytochromes P450 identifiés in vitro, il est possible de moduler in vivo ce métabolisme en terme pharmacocinétique. En clinique, la modalité de perfusion intraveineuse (continue vs courte) n'influence ni la pharmacocinétique ni la pharmacodynamique de l'ifosfamide dont le ratio d'activation est le plus défavorable, que ce soit en analyse n

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18

Arms, Lauren. "Inflammation-Induced Plasticity of Micturition Reflex Pathways." ScholarWorks @ UVM, 2011. http://scholarworks.uvm.edu/graddis/9.

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Although a seemingly basic and simple behavior, micturition necessitates precise integration and coordination of multiple divisions of the nervous system: visceral sensory, somatic motor, sympathetic, parasympathetic, as well as voluntary control from higher brain/ brainstem centers. When coordination of this circuitry falters, the consequences can be devastating and include severely decreased quality of life and substantial economic burden. This dissertation project investigates the potential role(s) of inflammatory mediators in bladder sensory physiology with the long term goal of elucidatin

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19

Manley, Jennifer J. "An assessment of DNA damage in rat sperm following cyclophosphamide treatment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0026/MQ50826.pdf.

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20

Xie, Hanjing. "Pharmacogenetic and pharmacokinetic studies of cyclophosphamide : in cell, animal and human /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-785-1/.

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21

Kelly, Sara M. "Paternal cyclophosphamide exposure exerts deleterious effects on early rat embryo development." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41634.

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Abstract (sommario):

Cyclophosphamide is an alkylating agent which has deleterious effects on reproduction in both males and females. When administered to male rats in chronic low doses (6 mg/kg/day), cyclophosphamide caused a dose-dependent increase in post-implantation death of the offspring. On day 7 of gestation, two days after implantation, the inner cell mass-derived embryonic tissues were retarded or absent while trophectoderm-derived extraembryonic tissues appeared normal. The preimplantation growth of embryos sired by cyclophosphamide-treated males was affected; as early as day 3 there was a significant d

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22

Li, Li. "Modification of antitumor immunity by cyclophosphamide given after active specific immunizaition." Kyoto University, 1998. http://hdl.handle.net/2433/182266.

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23

Roux, Stéphan. "Ciblage des Toll-Like récepteurs en immunithérapie antitumorale : Applications et perspectives thérapeutiques." Paris 11, 2009. http://www.theses.fr/2009PA11T013.

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24

Maillefert, Thierry. "Traitement des formes graves de connectivites et de vascularites par le cyclophosphamide en perfusions séquentielles : à propos de 20 cas." Montpellier 1, 1990. http://www.theses.fr/1990MON11069.

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25

Qiu, Ruolun. "ABCC2 (cMOAT) : role in 4-hydroxycyclophosphamide elimination from the liver and survival of high dose cyclophosphamide regimens /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/7962.

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26

Codrington, Alexis. "The impact of the chemotherapeutic drug cyclophosphamide on rat spermiogenic chromatin remodeling /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103039.

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Abstract (sommario):

Male reproductive health is of growing concern, as male toxicant exposure can affect progeny outcome; sperm chromatin structure integrity may be a contributing factor. The formation of mature sperm involves the expression of numerous proteins involved in organizing and packaging the chromatin in a specific manner; this ensures transmission and participation of the paternal genome in embryogenesis. Exposure of male rats to cyclophosphamide as spermatid chromatin is remodeled has an adverse effect on embryo development. The hypothesis of this thesis is that cyclophosphamide exposure causes genet

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27

Gerfen, Ashlee. "Chemomobilization with cyclophosphamide and filgrastim in multiple myeloma patients following lenalidomide treatment." The University of Arizona, 2012. http://hdl.handle.net/10150/623611.

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Class of 2012 Abstract<br>Specific Aims: Autologous stem cell transplant (ASCT) is the current gold standard following induction therapy to improve survival of multiple myeloma (MM). Lenalidomide (LEN) is used for treatment of MM before ASCT, but exposure may impair autologous peripheral blood stem cell (PBSC) mobilization. Chemomobilization with cyclophosphamide (CTX) has not been evaluated in this setting. CTX + filgrastim was investigated to determine if LEN-associated mobilization impairment can be abrogated. Methods: 36 pts (group A=12 pts who received ≥2 cycles of LEN and group B=24 pts

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28

Gerfen, Ashlee, and Myke Green. "Chemomobilization with Cyclophosphamide and Filgrastim in Multiple Myeloma Patients Following Lenalidomide Treatment." The University of Arizona, 2012. http://hdl.handle.net/10150/614472.

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Class of 2012 Abstract<br>Specific Aims: Autologous stem cell transplant (ASCT) is the current gold standard following induction therapy to improve survival of multiple myeloma (MM). Lenalidomide (LEN) is used for treatment of MM before ASCT, but exposure may impair autologous peripheral blood stem cell (PBSC) mobilization. Chemomobilization with cyclophosphamide (CTX) has not been evaluated in this setting. CTX + filgrastim was investigated to determine if LEN-associated mobilization impairment can be abrogated. Methods: 36 pts (group A=12 pts who received ≥2 cycles of LEN and group B=24 p

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29

Cárcano, Flavio Mavignier. "Quimioterapia à base de ciclofosfamida metronômica no tratamento de pacientes com câncer de próstata resistente à castração /." Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/88070.

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Orientador: Sérgio Vicente Serrano<br>Banca: Odair Carlito Michelin<br>Resumo: O câncer de próstata é o sexto tipo de câncer mais comum no mundo e cerca de três quartos dos casos ocorrem a partir dos 65 anos. O tratamento paliativo inicial para doença avançada contempla a castração, mas invariavelmente, metástases e resistência é desenvolvida em algum momento, quando então a quimioterapia é oferecida. Entretanto, a busca por tratamentos menos tóxicos se faz necessária para atender uma população cada vez mais idosa e com comorbidades que limitam o uso de drogas convencionais. As combinações à b

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30

Jezequel, Laetitia. "Développement d'approches prédictives pour l'ingénierie des protéines par évolution dirigée et application au développement d'une thérapie anticancéreuse." Paris 11, 2009. http://www.theses.fr/2009PA112260.

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Abstract (sommario):

Le souhait de réduire des effets secondaires associés aux anticancéreux a mené à considérer l’utilisation de prodrogues activables au site d’action, comme la cyclophosphamide (CPA). La CPA est activée majoritairement par le CYP2B6 humain avec une faible efficacité, obligeant à l’utilisation de concentrations importantes de prodrogue. Celles-ci peuvent être réduites par transfection au niveau de la tumeur d’un gène codant pour un P450 optimisé, possédant une efficacité catalytique élevée vis-à-vis de la CPA tout en étant le moins immunogène possible. Pour ce faire, en partant de la modélisation

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31

Daillere, Romain. "Impact du microbiote intestinal sur l’efficacité anti-tumorale de la chimiothérapie par cyclophosphamide." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS073.

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Plus de 50 ans après son approbation par les agences réglementaires, le cyclophosphamide (CTX) reste une drogue aux propriétés variées et aux effets pléiotropiques couramment utilisée en clinique. Cet agent cytotoxique, administré en cancérologie, possède des propriétés immuno-modulatrices et stimule les réponses immunitaires anti-tumorales. A doses métronomiques, le CTX induit notamment une polarisation des splénocytes CD4+ vers un profil Th1 et Th17, caractérisés par la sécrétion d’IFNet d’IL-17, nécessaire à l’activité tumoricide du CTX. Comme tout agent cytotoxique, le CTX cible les cell

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32

Li, Siu-ming Ian. "A study of cyclophosphamide on dextran sulfate sodium-induced ulcerative colitis in mice." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971994.

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33

Wathelet, Nathalie. "Etude de l'effet du cyclophosphamide sur la réponse immunitaire spécifique du mastocytome P815." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209566.

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La découverte des antigènes tumoraux dans les années 1980s a permis d’envisager l’élaboration de protocoles de vaccination de patients cancéreux. Les résultats obtenus chez les patients traités sont prometteurs mais encore insuffisants et la chimiothérapie reste, à ce jour, régulièrement utilisée dans le traitement de tumeurs.<p>\<br>Doctorat en Sciences<br>info:eu-repo/semantics/nonPublished

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34

Li, Siu-ming Ian, and 李紹銘. "A study of cyclophosphamide on dextran sulfate sodium-induced ulcerative colitis in mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971994.

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35

Anwer, Faiz, Seongseok Yun, Anju Nair, Yusuf Ahmad, Ravitharan Krishnadashan, and H. Joachim Deeg. "Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag." Hindawi, 2015. http://hdl.handle.net/10150/617180.

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UA Open Access Publishing Fund<br>Severe refractory ITP is clinically challenging and a variety of single or combination chemotherapies have been tried with limited outcome. We report a case of ITP that was unresponsive to multiple agents including high-dose steroid, IVIG, Rho(D) immune globulin, rituximab, cyclosporine, azathioprine, vincristine, mycophenolate mofetil, romiplostim, and eltrombopag; however, it achieved complete remission with combination treatment of cyclophosphamide and eltrombopag.

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36

Gardner, R., and John Bossaer. "Possible Drug-Induced Pancreatitis in a Patient Receiving Cyclophosphamide, Vincristine, and Prednisone Chemotherapy." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7797.

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Drug-induced pancreatitis is a condition characterized by sudden inflammation of the pancreas that can be mild or severe but usually subsides. Signs and symptoms consist of abdominal pain, nausea/vomiting, low-grade fever and pain radiating to the lower back. The incidence of acute drug-induced pancreatitis is approximately 2% but in patients that have disease states that predispose them to the development of pancreatitis, such as malignancy, hypercalcemia, tumor lysis syndrome, and immunosuppression it is found to be much higher. Conditions that should be considered in the differential diagno

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37

Horiuchi, Yuka. "Lactoferrin is associated with a decrease in oocyte depletion in mice receiving cyclophosphamide." Kyoto University, 2009. http://hdl.handle.net/2433/126421.

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38

Béthoux, François. "Essai therapeutique de cylcophosphamide dans la maladie de charcot." Lyon 1, 1990. http://www.theses.fr/1990LYO1M313.

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39

TSTE, WOON YUEN KHEE KIM. "Cancer du sein : chimiotherapie adjuvante ; resultats a long terme d'une serie de patientes n+ traitees de 1978 a 1992 a la clinique sainte-catherine par cmf ou avcf adjuvant." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20143.

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40

Guenther, Michael. "Cancer Therapy with Metronomically Scheduled Cyclophosphamide: Experimental Modalities within GDEPT and Tumor Escape Mechanisms." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-68423.

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41

Grenier, Lisanne. "The effects of paternal exposure to cyclophosphamide on the development of cleavage stage embryos." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110358.

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Abstract (sommario):

Abnormal embryonic development can arise from maternal or paternal exposure to therapeutic agents, environmental toxicants or social habits. Such exposures prior to conception may damage the gametes and have detrimental effects on the developing embryo. When male rats are exposed to the chemotherapeutic agent, cyclophosphamide, the genomic integrity of the male germ cells is altered. The goals of these studies were to determine the impact of paternal preconceptional exposure to cyclophosphamide on embryonic development and to elucidate how cleavage stage embryos respond to DNA damage in the ma

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42

Aguilar, Adriana. "Stress response mechanisms during rat spermatogenesis and the effects of the anticancer agent cyclophosphamide." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85111.

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Abstract (sommario):

Exposure of males to drugs or environmental chemicals can alter reproductive health and affect progeny outcome. The quality of the male germ cell is determined in part by the presence and function of stress response mechanisms. During spermatogenesis, different germ cell types display differential susceptibility to toxicants, suggesting there is variation in the presence and function of stress response mechanisms. Exposure of male rats to cyclophosphamide, a commonly used anticancer and immunosuppressive drug, alters male fertility and progeny outcome in a male-germ cell phase specific

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43

Viaud, Sophie. "Etude des effets du cyclophosphamide sur l’immunité anti-tumorale : relations avec le microbiote intestinal." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T064.

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Les chimiothérapies conventionnelles anticancéreuses ont été développées dans le but de traiter le cancer par élimination directe et/ou par inhibition de croissance les cellules tumorales en division. Les cellules endothéliales en prolifération à l’origine de la vascularisation intra-tumorale sont également connues pour être sensibles aux effets cytotoxiques des agents anticancéreux. Depuis, de nombreuses études ont montré que certaines thérapies conventionnelles peuvent être exploitées pour leurs capacités anti-angiogéniques (Browder et al. Cancer Research 2000). La stratégie mise en place co

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44

Morozova, O. M. "Features of the reyer's patches small intestine of the immature rats after cyclophosphamide ingection." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/31968.

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Peyer's patches of the small intestine is one of the first barrier against antigens in the human body. They are dynamic systems, and actively respond to external and internal factors. The aim of this study was to determine the effect of cyclophosphamide on the structure of Peyer's patches of the small intestine of immature rats.The study was conducted on 36 albino immature male rats weighing 60-90 g. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/31968

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45

Meen, Murielle. "La cystite induite par le cyclophosphamide chez le rat : un nouveau modele comportemental de douleur viscerale.aspects methodologiques,physiopathologiques et pharmacologiques (doctorat)." Clermont-Ferrand 1, 2001. http://www.theses.fr/2001CLF1PP07.

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46

Liang, Lijin. "Prevention of cyclophosphamide-accelerated diabetes in NOD mice with the phosphodiesterase inhibitors Pentoxifylline and Rolipram." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0023/MQ50821.pdf.

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47

Harrouk, Wafa A. "Consequences of paternal exposure to the anti-cancer drug, cyclophosphamide, on rat pre-implantation development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0029/NQ64572.pdf.

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48

Troster, Charles Micah Smolkin. "Trace analysis of cyclophosphamide and its metabolites in urine by liquid chromatography-tandem mass spectrometry." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29263.

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Abstract (sommario):

Cyclophosphamide (CP) is an antineoplastic drug used to treat a wide variety of cancers and immune disorders. CP is also a highly toxic alkylating agent, classified as an IARC Group 1 carcinogen. Workers in health-care environments are vulnerable to occupational exposure to CP, primarily via inhalation and dermal absorption. CP is a prodrug; both its therapeutic effectiveness and toxicity are activated through metabolism. To date, however, no study measuring occupational exposure to CP has successfully analyzed its metabolites. The main objective of this work was to develop an analytical metho

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49

Liang, Lijin 1966. "Prevention of cyclophosphamide-accelerated diabetes in NOD mice with the phosphodiesterase inhibitors Pentoxifylinne and Rolipram." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21594.

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Interleukin (IL)-12, interferon (IFN)-gamma, and other inflammatory cytokines play an important role in the pathogenesis of autoimmune insulitis and diabetes in NOD mice, and inhibition of these cytokines is likely to be beneficial. In this study, we found that Pentoxifylline (PTX) and Rolipram (phosphodiesterase [PDE] inhibitors that induce increased intracellular cAMP) can block inflammatory cytokine production. Inhibition of IL-12 and IFN-gamma secretion was demonstrated in macrophages activated with lipopolysaccharide or T-cells stimulated through the CD3/T-cell receptor complex, respectiv

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50

Harrouk, Wafa. "Consequences of paternal exposure to the anti-cancer drug, cyclophosphamide, on rat pre-implantation development." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36604.

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Abstract (sommario):

Administration of cyclophosphamide to males targets the germ cells and causes DNA damage including single strand breaks and DNA-DNA cross links. When males are treated with a chronic low dose of cyclophosphamide and then mated to normal females, progeny loss is manifested at the pre- and post-implantation stages of development. The earliest events that lead to embryonic loss were traced to day 2 of gestation when embryos had a decreased DNA synthesis profile and lower cell numbers than control litters. I investigated the hypothesis that chronic exposure of male rats to cyclophosphamide alters

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