Bibliografie tematiche / CYP199A4

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Letteratura scientifica selezionata sul tema "CYP199A4"

Autore: Grafiati
Pubblicato: 10 dicembre 2022
Ultima modifica: 31 luglio 2025

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Articoli di riviste sul tema "CYP199A4"

1

Yuan, Chang, Jiaqi Xu, Shun Wang, Ye-Guang Fang та Hongwei Tan. "Mechanistic Insights into CYP199A4-Catalyzed α-Hydroxyketone Formation and Hydrogen Bond-Assisted C–C Bond Cleavage Catalyzed by the CYP199A4 F182L Mutant". International Journal of Molecular Sciences 26, № 4 (2025): 1526. https://doi.org/10.3390/ijms26041526.

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Abstract (sommario):
CYP199A4 is a cytochrome P450 and can catalyze the hydroxylation of 4-propionylbenzoic acid (4-pIBA) to generate α-hydroxyketone with high stereoselectivity. The F182L mutant of CYP199A4 (F182L-CYP199A4) has been shown to support the cleavage of the C–C bond between the carbonyl and hydroxyl groups of α-hydroxyketone, whereas wild-type CYP199A4 cannot. To uncover how the Phe182 regulates substrate reactivity, we conducted classical molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) MD simulations on these systems. The results predicted that the formation of α-hydroxyketo
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Chao, Rebecca R., James J. De Voss, and Stephen G. Bell. "The efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4." RSC Advances 6, no. 60 (2016): 55286–97. http://dx.doi.org/10.1039/c6ra11025h.

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Coleman, Tom, Rebecca R. Chao, John B. Bruning, James J. De Voss, and Stephen G. Bell. "CYP199A4 catalyses the efficient demethylation and demethenylation of para-substituted benzoic acid derivatives." RSC Advances 5, no. 64 (2015): 52007–18. http://dx.doi.org/10.1039/c5ra08730a.

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Abstract (sommario):
CYP199A4, a cytochrome P450 enzyme from Rhodopseudomonas palustris HaA2, is able to efficiently demethylate a range of benzoic acids at the para-position. It can also catalyse demethenylation reactions.
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Faletrov, Y. V., V. O. Maliugin, N. S. Frolova, and V. M. Shkumatov. "<i>In silico</i> evaluation of new affine interactions of methylcoumarin with cytochromes P450." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 58, no. 2 (2022): 186–90. http://dx.doi.org/10.29235/1561-8331-2022-58-2-186-190.

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Abstract (sommario):
4-methyl-7-methoxycoumarin (CumOMe) has been synthesized and in silico calculations demonstrated localization of methoxy group within 0.4 nm from Fe ion of hem groups for some structures of human CYP19 &amp; CYP46 as well as CYP152 S. paucimobilis, CYP158 St. coelicolor, HMUO C. diphtheriae, XPLA R. rhodochrous, CYP199A4 Rh. palustris, CYP101A1 Ps. putida and CYP51 M. tuberculosis.
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Bell, Stephen G., Wen Yang, Adrian B. H. Tan, et al. "The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site." Dalton Transactions 41, no. 28 (2012): 8703. http://dx.doi.org/10.1039/c2dt30783a.

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Bell, Stephen G., Adrian B. H. Tan, Eachan O. D. Johnson, and Luet-Lok Wong. "Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2." Mol. BioSyst. 6, no. 1 (2009): 206–14. http://dx.doi.org/10.1039/b913487e.

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Coleman, Tom, Siew Hoon Wong, Matthew N. Podgorski, John B. Bruning, James J. De Voss, and Stephen G. Bell. "Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris Catalyzes Heteroatom Dealkylations, Sulfoxidation, and Amide and Cyclic Hemiacetal Formation." ACS Catalysis 8, no. 7 (2018): 5915–27. http://dx.doi.org/10.1021/acscatal.8b00909.

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Coleman, Tom, Rebecca R. Chao, James J. De Voss, and Stephen G. Bell. "The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864, no. 6 (2016): 667–75. http://dx.doi.org/10.1016/j.bbapap.2016.03.006.

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Vanselow, Jens, Alan J. Conley, Cynthia J. Corbin, and Trish Berger. "Genomic Structure of the Porcine CYP19 Locus and Expression of the CYP19A3 Paralog." Genes 12, no. 4 (2021): 533. http://dx.doi.org/10.3390/genes12040533.

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Abstract (sommario):
Proper, tissue-specific regulation of CYP19, the gene encoding aromatase, the key enzyme of estrogen synthesis, is essential for reproductive processes. Here, we analyzed transcriptional regulation of the porcine CYP19 in female and male gonads and brain by 5’RACE and RT-PCR and comprehensively mapped the pig CYP19 locus by in silico analysis. Our data revealed that the complete locus, including three paralogous copies, CYP19A1, CYP19A2 and CYP19A3, spans approximately 330 kb of the porcine chromosome 1. The locus also harbors the first exon of the Gliomedin gene (GLDN) in reverse orientation.
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Bell, Stephen G., Ruimin Zhou, Wen Yang, et al. "Investigation of the Substrate Range of CYP199A4: Modification of the Partition between Hydroxylation and Desaturation Activities by Substrate and Protein Engineering." Chemistry - A European Journal 18, no. 52 (2012): 16677–88. http://dx.doi.org/10.1002/chem.201202776.

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Tesi sul tema "CYP199A4"

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Youn, Jin Young. "Polymorphisms of FSHR, ESR and CYP19A1 and ovarian stimulation outcome." Thesis, Boston University, 2012. https://hdl.handle.net/2144/31627.

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Abstract (sommario):
Thesis (M.A.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Ovarian stimulation is frequently used in many assisted reproductive technologies (ART) procedures to increase the number of dominant follicles. However, achieving the optimal response to ovarian stimulation w
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Escobar, Gabriela Fortes. "Polimorfismos genéticos dos genes CYP19A1 e NFKB1 e o risco de melanoma cutâneo." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/116777.

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Abreu, Lauriane Giselle de. "Expressão do gene da aromatase (CYP19A1) nas células da granulosa murais luteinizadas de mulheres com endometriose submetidas a técnicas de reprodução assistida." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-27092013-094914/.

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Abstract (sommario):
Introdução:Até 60% das mulheres com endometriose apresentam como sintoma a infertilidade. Entretanto, os mecanismos envolvidos ainda permanecem não totalmente esclarecidos, especialmente quando não há distorção da anatomia pélvica. A etiologia multifatorial e comprometimento poligênico nesta doença têm sido amplamente aceitos. A aromatase é uma molécula das mais estudadas e há evidências de aumento da expressão do seu gene no endométrio eutópico e ectópico na endometriose. Esta enzima, codificada pelo gene CYP19A1, converte andrógenos a estrógenos e está presente normalmente nas célul
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Viciano, Gonzalo Ignacio. "A theoretical study on the mechanism of the oxidation of substrates by human aromatase enzyme (CYP19A1)." Doctoral thesis, Universitat Jaume I, 2016. http://hdl.handle.net/10803/392148.

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Abstract (sommario):
The enzyme Cytochrome P450 aromatase plays an essential role in the biosynthesis of estrogens, and its inhibition is an important target for the development of drugs for the treatment of breast cancer. The main purpose of the present thesis is to improve the understanding of the catalytic mechanism and the biochemistry of this enzyme from the standpoint of theoretical chemistry. The results of this thesis have been divided into three main sections: (1) Study of the reactive species of the enzyme aromatase: Compound I; (2) Study of the hydroxylation of the natural substrate androstenedione, dur
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Reuter, Benoit [Verfasser], and Peter [Gutachter] Fasching. "Genetische Polymorphismen im Aromatasegen (CYP19A1) und deren Assoziation mit dem Geburtsgewicht des Kindes / Benoit Reuter ; Gutachter: Peter Fasching." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017. http://d-nb.info/1143231996/34.

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Schmid, Heidi. "" Aromatase and the Pharmacogenomic Profile - Influence of CYP19A1 polymorphisms in the response of breast cancer patients treated with aromatase inhibitors"." Master's thesis, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/57191.

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Schmid, Heidi. "" Aromatase and the Pharmacogenomic Profile - Influence of CYP19A1 polymorphisms in the response of breast cancer patients treated with aromatase inhibitors"." Dissertação, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/57191.

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Nunes, Marília Danyelle. "Análise do polimorfismo nos genes CYP19a e CYP19b em Oreochromis niloticus da linhagem Supreme e suas relações com caracteres reprodutivos." Universidade Federal de Pelotas, 2011. http://repositorio.ufpel.edu.br/handle/ri/2590.

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Abstract (sommario):
Made available in DSpace on 2014-08-20T14:38:44Z (GMT). No. of bitstreams: 1 Dissertacao_Marilia_Danyelle_Nunes.pdf: 2251889 bytes, checksum: 70b649c990ada42de45d8b20813f9a4d (MD5) Previous issue date: 2011-02-27<br>The aromatase enzyme complex is responsible for converting androgens into estrogens in vertebrates. One of the key enzymes of this complex is the cytochrome P450arom gene expression and regulation of this enzyme is directly linked to sexual differentiation. Estrogen is essential for the development of the gonads and various physiological processes, ranging from normal growth to
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Thaler, Kerstin [Verfasser], and Peter Andreas [Gutachter] Fasching. "Bedeutung von zwei Single Nucleotid Polymorphismen im Aromatase-Gen (CYP19A1) für die Entstehung einer Mammakarzinomerkrankung - Eine Fall-Kontroll-Studie / Kerstin Thaler ; Gutachter: Peter Andreas Fasching." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017. http://d-nb.info/113917858X/34.

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Bouchard, Marie-France. "Fonctions aberrantes des facteurs de transcription GATA chez l'humain : régulation de l'expression ectopique du gène CYP19A1 par GATA3/4 dans les cellules de cancer du sein et effet des mutations ponctuelles de GATA4 sur la régulation de ses gènes cibles gonadiques." Thesis, Université Laval, 2009. http://www.theses.ulaval.ca/2009/26555/26555.pdf.

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Capitoli di libri sul tema "CYP199A4"

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Akhtar, Muhammad, and J. Neville Wright. "Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16009-2_4.

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Dam, Anh Tuan, Mariel Galotta, Yuhei Eto, et al. "Exploring Tissues-Bias DNA Methylation of Two Sex-Related Genes (Cyp19a1 and Dmrt1) in Correlation with Gene Expression in Japanese Anchovy (Engraulis Japonicus)." In Mathematics for Industry. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-7850-8_13.

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"CYP19A1." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_310933.

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Atti di convegni sul tema "CYP199A4"

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Vinnikava, V. Y., Alena Mikhalenka, Alena Kuzminova, DA V. Bajda та A. V. Kilchevsky. "CYP19A1 and СOMT polymorphisms in elderly people and long-livers of Belarus". У XIth International Congress of Geneticists and Breeders from the Republic of Moldova. Scientific Association of Geneticists and Breeders of the Republic of Moldova, Institute of Genetics, Physiology and Plant Protection, Moldova State University, 2021. http://dx.doi.org/10.53040/cga11.2021.047.

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Lin, Jennifer H., Shumin M. Zhang, Marc J. Gunter, et al. "Abstract A67: The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women." In Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Oct 22-25, 2011; Boston, MA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1940-6207.prev-11-a67.

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Starlard-Davenport, Athena, Rosalind B. Penney, Ishwori Dhakal, and Susan Kadlubar. "Abstract 547: Ethnic differences in CYP19A1 intronic SNPs and haplotype distributions among African American and Caucasian populations." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-547.

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Massillo, Cintia, Guillermo N. Dalton, Juliana Porretti, et al. "Abstract 5496: Intratumor estradiol increment mediated by CtBP1/CYP19A1 decreases the proliferation of androgen insensitive prostate tumor cells." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5496.

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Park, I., J. Ro, K. Lee, S. Kim, and Y. Lee. "Single Nucleotide Polymorphisms of CYP19A1, rs10459592 and rs4775936 Predict Clinical Benefit of Letrozole in Patients with Metastatic Breast Cancer." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-2117.

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Johansson, H., S. Gandini, V. Aristarco, et al. "Abstract P4-08-05: Impact of common polymorphisms of CYP19A1 and UGT2B17 gene deletion on early endocrine-responsive postmenopausal breast cancer." In Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.sabcs17-p4-08-05.

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Wang, X., X. Shao, Y. Zheng, L. Shi, and Y. Huang. "Abstract P3-07-22: RS1008805 polymorphism in CYP19A1 gene is related to the efficacy of hormone therapy in early breast cancer." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p3-07-22.

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Lo, Wing-Yee, Werner Schroth, Reiner Hoppe, et al. "Abstract 5483: CYP19A1 genetic variation is a potential predictor of outcome in ER-positive postmenopausal early breast cancer patients treated with tamoxifen." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5483.

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Dabydeen, Sarah A., Weisheng Wang, Edgar S. Diaz-Cruz, Levy Kopelovich, Robert I. Glazer, and Priscilla A. Furth. "Abstract 197: Reduction in lobular but not ductal hyperplasia by the PGR inhibitor ORG33628 in a CYP19A1 overexpressing mouse model of breast cancer risk." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-197.

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Chachibaia, Tamar, and Joy Hoskeri. "In silico computer simulation risk assessment of triazole fungicides on human cytochrome p450 aromatase enzyme: cyp19a1 inhibition by triazoles using autodock software." In MOL2NET, International Conference on Multidisciplinary Sciences. MDPI, 2015. http://dx.doi.org/10.3390/mol2net-1-f002.

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