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Articoli di riviste sul tema "CYP199A4"

Autore: Grafiati

Pubblicato: 10 dicembre 2022

Ultima modifica: 31 luglio 2025

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1

Yuan, Chang, Jiaqi Xu, Shun Wang, Ye-Guang Fang та Hongwei Tan. "Mechanistic Insights into CYP199A4-Catalyzed α-Hydroxyketone Formation and Hydrogen Bond-Assisted C–C Bond Cleavage Catalyzed by the CYP199A4 F182L Mutant". International Journal of Molecular Sciences 26, № 4 (2025): 1526. https://doi.org/10.3390/ijms26041526.

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CYP199A4 is a cytochrome P450 and can catalyze the hydroxylation of 4-propionylbenzoic acid (4-pIBA) to generate α-hydroxyketone with high stereoselectivity. The F182L mutant of CYP199A4 (F182L-CYP199A4) has been shown to support the cleavage of the C–C bond between the carbonyl and hydroxyl groups of α-hydroxyketone, whereas wild-type CYP199A4 cannot. To uncover how the Phe182 regulates substrate reactivity, we conducted classical molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) MD simulations on these systems. The results predicted that the formation of α-hydroxyketo

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2

Chao, Rebecca R., James J. De Voss, and Stephen G. Bell. "The efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4." RSC Advances 6, no. 60 (2016): 55286–97. http://dx.doi.org/10.1039/c6ra11025h.

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3

Coleman, Tom, Rebecca R. Chao, John B. Bruning, James J. De Voss, and Stephen G. Bell. "CYP199A4 catalyses the efficient demethylation and demethenylation of para-substituted benzoic acid derivatives." RSC Advances 5, no. 64 (2015): 52007–18. http://dx.doi.org/10.1039/c5ra08730a.

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CYP199A4, a cytochrome P450 enzyme from Rhodopseudomonas palustris HaA2, is able to efficiently demethylate a range of benzoic acids at the para-position. It can also catalyse demethenylation reactions.

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4

Faletrov, Y. V., V. O. Maliugin, N. S. Frolova, and V. M. Shkumatov. "<i>In silico</i> evaluation of new affine interactions of methylcoumarin with cytochromes P450." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 58, no. 2 (2022): 186–90. http://dx.doi.org/10.29235/1561-8331-2022-58-2-186-190.

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4-methyl-7-methoxycoumarin (CumOMe) has been synthesized and in silico calculations demonstrated localization of methoxy group within 0.4 nm from Fe ion of hem groups for some structures of human CYP19 & CYP46 as well as CYP152 S. paucimobilis, CYP158 St. coelicolor, HMUO C. diphtheriae, XPLA R. rhodochrous, CYP199A4 Rh. palustris, CYP101A1 Ps. putida and CYP51 M. tuberculosis.

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5

Bell, Stephen G., Wen Yang, Adrian B. H. Tan, et al. "The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site." Dalton Transactions 41, no. 28 (2012): 8703. http://dx.doi.org/10.1039/c2dt30783a.

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6

Bell, Stephen G., Adrian B. H. Tan, Eachan O. D. Johnson, and Luet-Lok Wong. "Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2." Mol. BioSyst. 6, no. 1 (2009): 206–14. http://dx.doi.org/10.1039/b913487e.

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7

Coleman, Tom, Siew Hoon Wong, Matthew N. Podgorski, John B. Bruning, James J. De Voss, and Stephen G. Bell. "Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris Catalyzes Heteroatom Dealkylations, Sulfoxidation, and Amide and Cyclic Hemiacetal Formation." ACS Catalysis 8, no. 7 (2018): 5915–27. http://dx.doi.org/10.1021/acscatal.8b00909.

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8

Coleman, Tom, Rebecca R. Chao, James J. De Voss, and Stephen G. Bell. "The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864, no. 6 (2016): 667–75. http://dx.doi.org/10.1016/j.bbapap.2016.03.006.

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9

Vanselow, Jens, Alan J. Conley, Cynthia J. Corbin, and Trish Berger. "Genomic Structure of the Porcine CYP19 Locus and Expression of the CYP19A3 Paralog." Genes 12, no. 4 (2021): 533. http://dx.doi.org/10.3390/genes12040533.

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Abstract (sommario):

Proper, tissue-specific regulation of CYP19, the gene encoding aromatase, the key enzyme of estrogen synthesis, is essential for reproductive processes. Here, we analyzed transcriptional regulation of the porcine CYP19 in female and male gonads and brain by 5’RACE and RT-PCR and comprehensively mapped the pig CYP19 locus by in silico analysis. Our data revealed that the complete locus, including three paralogous copies, CYP19A1, CYP19A2 and CYP19A3, spans approximately 330 kb of the porcine chromosome 1. The locus also harbors the first exon of the Gliomedin gene (GLDN) in reverse orientation.

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10

Bell, Stephen G., Ruimin Zhou, Wen Yang, et al. "Investigation of the Substrate Range of CYP199A4: Modification of the Partition between Hydroxylation and Desaturation Activities by Substrate and Protein Engineering." Chemistry - A European Journal 18, no. 52 (2012): 16677–88. http://dx.doi.org/10.1002/chem.201202776.

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11

Kazeto, Yukinori, Shigeho Ijiri, Allen R. Place, Yonathan Zohar, and John M. Trant. "The 5′-Flanking Regions of CYP19A1 and CYP19A2 in Zebrafish." Biochemical and Biophysical Research Communications 288, no. 3 (2001): 503–8. http://dx.doi.org/10.1006/bbrc.2001.5796.

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12

Kazeto, Y., and J. M. Trant. "Molecular biology of channel catfish brain cytochrome P450 aromatase (CYP19A2): cloning, preovulatory induction of gene expression, hormonal gene regulation and analysis of promoter region." Journal of Molecular Endocrinology 35, no. 3 (2005): 571–83. http://dx.doi.org/10.1677/jme.1.01805.

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Cytochrome P450 aromatase (CYP19) converts androgens to estrogens. Unlike mammals, teleosts have two CYP19 genes, expressed differentially in ovary (CYP19A1) and neuronal tissues (CYP19A2). The primary purpose of this study was to demonstrate the potential involvement of CYP19A2 in the reproductive endocrinology of teleosts. Channel catfish CYP19A2 (ccCYP19A2) cDNAs were isolated from the brain using a PCR-based strategy. The ccCYP19A2 cDNA putatively encodes 500 amino acids which conferred aromatase activity in transfected COS-7 cells. Additionally, an alternatively spliced transcript was iso

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13

Dong, Wu, and Kristine L. Willett. "Local expression of CYP19A1 and CYP19A2 in developing and adult killifish (Fundulus heteroclitus)." General and Comparative Endocrinology 155, no. 2 (2008): 307–17. http://dx.doi.org/10.1016/j.ygcen.2007.05.018.

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14

Bimonte, Viviana M., Francesco Marampon, Ambra Antonioni, et al. "Phosphodiesterase Type-5 Inhibitor Tadalafil Modulates Steroid Hormones Signaling in a Prostate Cancer Cell Line." International Journal of Molecular Sciences 22, no. 2 (2021): 754. http://dx.doi.org/10.3390/ijms22020754.

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Background: The androgen receptor (AR) plays a key role in normal prostate homeostasis and in prostate cancer (PCa) development, while the role of aromatase (Cyp19a1) is still unclear. We evaluated the effects of a treatment with Tadalafil (TAD) on both these proteins. Methods: Androgen-sensitive human PCa cell line (LnCAP) was incubated with/without TAD (10−6 M) and bicalutamide (BCT) (10−4 M) to evaluate a potential modulation on cell proliferation, protein and mRNA expression of Cyp19a, AR and estrogen receptor-β (ERβ), respectively. Results: TAD increased early AR nuclear translocation (p

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15

Jędrzejczak, M., I. Szatkowska, S. Zych, W. Grzesiak, E. Czerniawska-Piątkowska, and A. Dybus. "Evaluation of associations of the polymorphism in the placentaspecific promoter 1.1 of the <i>CYP19</i> gene in Black-and-White and Jersey cattle with milk production traits (short communication)." Archives Animal Breeding 49, no. 4 (2006): 311–14. http://dx.doi.org/10.5194/aab-49-311-2006.

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Abstract. The relationship between the SNP of the cytochrome P450 gene (CYP19-PvuII) and milk production traits of Black-and-White and Jersey cattle were analysed. A total of 437 cows were included in the study. A PCR-RFLP was used to genotype. The frequencies of genotypes and alleles for the Black-and-White cows were as follows: 0.8985 – AA, 0.0977 – AB, 0.0038 – BB, and 0.9474 – CYP19A, 0.0526 – CYP19B. In the Jersey, all cows were genotyped as CYP19AA (no polymorphism). There weren’t any associations between CYP19-PvuII polymorphism and milk production traits of the investigated cows.

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16

Furuya, Toshiki, Yuka Arai, and Kuniki Kino. "Biotechnological Production of Caffeic Acid by Bacterial Cytochrome P450 CYP199A2." Applied and Environmental Microbiology 78, no. 17 (2012): 6087–94. http://dx.doi.org/10.1128/aem.01103-12.

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ABSTRACTCaffeic acid is a biologically active molecule that has various beneficial properties, including antioxidant, anticancer, and anti-inflammatory activities. In this study, we explored the catalytic potential of a bacterial cytochrome P450, CYP199A2, for the biotechnological production of caffeic acid. When the CYP199A2 enzyme was reacted withp-coumaric acid, it stoichiometrically produced caffeic acid. The crystal structure of CYP199A2 shows that Phe at position 185 is situated directly above, and only 6.35 Å from, the heme iron. This F185 residue was replaced with hydrophobic or hydrox

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17

Zhang, Yan, Xiang Chen, Zhinan Zhou, Xingzhou Tian, Peifang Yang, and Kaibing Fu. "CYP19A1 May Influence Lambing Traits in Goats by Regulating the Biological Function of Granulosa Cells." Animals 12, no. 15 (2022): 1911. http://dx.doi.org/10.3390/ani12151911.

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Abnormal expression of CYP19A1, a gene related to steroid hormone synthesis, causes steroid hormone disruption and leads to abnormal ovulation in granulosa cells. However, the exact mechanism of CYP19A1 regulation is unclear. In this study, we confirmed the localization of CYP19A1 in goat ovarian tissues using immunohistochemistry. Subsequently, we investigated the effects of CYP19A1 on granulosa cell proliferation, steroid hormone secretion, and expression of candidate genes for multiparous traits by overexpressing and silencing CYP19A1 in goat granulosa cells (GCs). The immunohistochemistry

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18

Li, Huitao, Yu Zhao, Lanlan Chen, et al. "Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms." BioMed Research International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/8284097.

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Human aromatase (CYP19A1) is an important enzyme, which produces estrogen from androgen for maintaining the female reproductive function and pregnancy. Triclocarban and triclosan are antimicrobial chemicals added to personal care, household, and industrial products. They could be endocrine disruptors and may disrupt human CYP19A1 activity. In the present study, we investigated the effects of triclocarban and triclosan on estradiol production and human CYP19A1 activity in JEG-3 cells. Triclocarban and triclosan reduced estradiol production in JEG-3 cells. Triclocarban and triclosan inhibited hu

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19

Meyer, Ashley E., Caroline A. Pfeiffer, Kelsey E. Brooks, et al. "New perspective on conceptus estrogens in maternal recognition and pregnancy establishment in the pig†." Biology of Reproduction 101, no. 1 (2019): 148–61. http://dx.doi.org/10.1093/biolre/ioz058.

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Abstract The proposed signal for maternal recognition of pregnancy in pigs is estrogen (E2), produced by the elongating conceptuses between days 11 to 12 of pregnancy with a more sustained increase during conceptus attachment and placental development on days 15 to 30. To understand the role of E2 in porcine conceptus elongation and pregnancy establishment, a loss-of-function study was conducted by editing aromatase (CYP19A1) using CRISPR/Cas9 technology. Wild-type (CYP19A1+/+) and (CYP19A1−/−) fibroblast cells were used to create embryos through somatic cell nuclear transfer, which were trans

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20

Ge, Hongshan, Lanlan Chen, Ying Su, Chunyan Jin, and Ren-Shan Ge. "Effects of Folpet, Captan, and Captafol on Human Aromatase in JEG-3 Cells." Pharmacology 102, no. 1-2 (2018): 81–87. http://dx.doi.org/10.1159/000484171.

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Background: Estradiol, produced by aromatase (CYP19A1), is very important for reproduction. Folpet, captan, and captafol belong to the phthalimide class of fungicides. They are used to protect the leaves of plants or fruits. They could be endocrine disruptors and may disrupt CYP19A1 activity. Methods: In the present study, we investigated the effects of folpet, captan, and captafol on estradiol production and human CYP19A1 activity in JEG-3 cells. Results: Folpet, captan, and captafol decreased estradiol production in JEG-3 cells in a concentration-dependent manner. Folpet, captan, and captafo

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21

Choi, Hyeonhae, Ki-Young Ryu, and Jaesook Roh. "Krüppel-like factor 4 plays a role in the luteal transition in steroidogenesis by downregulating Cyp19A1 expression." American Journal of Physiology-Endocrinology and Metabolism 316, no. 6 (2019): E1071—E1080. http://dx.doi.org/10.1152/ajpendo.00238.2018.

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The transition from granulosa cell (GC) to luteal cell involves a change from estrogen production to predominantly progesterone production. We analyzed the role of Krüppel-like factor 4 ( Klf4), a transcriptional repressor used to generate pluripotent cells, in that transition. After luteinizing hormone (LH)/human chorionic gonadotropin treatment of preovulatory follicles, a major but transient increase in Klf4 transcript levels was detected. Therefore, we enquired whether Klf4 is involved in the rapid decline of aromatase, the key estrogen-producing enzyme, using preovulatory GCs obtained fro

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22

Yazawa, Takashi, Mohammad Sayful Islam, Yoshitaka Imamichi, et al. "Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian Species." Animals 13, no. 4 (2023): 622. http://dx.doi.org/10.3390/ani13040622.

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During mammalian gestation, large amounts of progesterone are produced by the placenta and circulate for the maintenance of pregnancy. In contrast, primary plasma estrogens are different between species. To account for this difference, we compared the expression of ovarian and placental steroidogenic genes in various mammalian species (mouse, guinea pig, porcine, ovine, bovine, and human). Consistent with the ability to synthesize progesterone, CYP11A1/Cyp11a1, and bi-functional HSD3B/Hsd3b genes were expressed in all species. CYP17A1/Cyp17a1 was expressed in the placenta of all species, exclu

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23

Chu, Ma, Sun, et al. "Leptin Receptor Mediates Bmal1 Regulation of Estrogen Synthesis in Granulosa Cells." Animals 9, no. 11 (2019): 899. http://dx.doi.org/10.3390/ani9110899.

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Chronobiology affects female fertility in mammals. Lepr is required for leptin regulation of female reproduction. The presence of E-box elements in the Lepr promoter that are recognized and bound by clock genes to initiate gene transcription suggested that circadian systems might regulate fertility through Lepr. However, it is unclear whether Bmal1, a key oscillator controlling other clock genes, is involved in leptin regulation in hormone synthesis through Lepr. In this study, serum estradiol (E2) concentration and the expressions of Bmal1, Lepr, Cyp19a1, and Cyp11a1 genes were found to displ

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24

Gu, Yu, Wenbin Xu, Bole Zhuang, and Wei Fu. "Role of A-kinase anchoring protein 95 in the regulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) in human ovarian granulosa cells." Reproduction, Fertility and Development 30, no. 8 (2018): 1128. http://dx.doi.org/10.1071/rd17313.

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Irregular expression of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) is involved in the development of polycystic ovary syndrome (PCOS). Activation of the cAMP/protein kinase A (PKA)/cAMP response element-binding protein (CREB) pathway plays a crucial role in FSH regulation of CYP19A1 in human ovarian granulosa cells. A-Kinase anchor protein 95 (AKAP95) is known to confine PKA to the nucleus. However, it is unclear whether anchoring PKA to the nucleus is essential for the induction of CYP19A1 by FSH in human ovarian granulosa cells. Using the human granulosa cell line KGN and prima

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25

Kudryavtseva, E. V., N. V. Kurbatova, V. V. Кovalev, and D. K. Islamidi. "Investigating genetic predisposition to premature decline in ovarian reserve." Obstetrics, Gynecology and Reproduction 16, no. 3 (2022): 266–76. http://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2022.301.

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Introduction. Normal ovarian reserve (OR) determining the ovarian response to follicle development containing fully-featured oocytes is an important factor in pregnancy, including assisted reproductive technology (ART) programs. The causes of premature OR decrease are multifactorial. The study of gene polymorphism as a cause of the premature OR decrease deserves attention.Aim: to determine genetic predisposition to premature OR decrease and create a prognostic model based on study results.Materials and Methods. A retrospective comparative cohort study was conducted. A total of 200 reproductive

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26

FURUYA, Toshiki, and Kuniki KINO. "Biocatalytic Synthesis of Dihydroxynaphthoic Acids by Cytochrome P450 CYP199A2." Bioscience, Biotechnology, and Biochemistry 73, no. 12 (2009): 2796–99. http://dx.doi.org/10.1271/bbb.90624.

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27

Ahmed, Nashwa E., Ghada M. Shams, Omnia E. Abdallah, Adel M. Elkholy, Manar G. Abd Elrazik, and Shaymaa M. Abdelrahman. "Exploring the role of CYP19A1 single nucleotide polymorphisms in the pathogenesis of female pattern hair loss." Egyptian Journal of Dermatology and Venereology 45, no. 2 (2025): 142–47. https://doi.org/10.4103/ejdv.ejdv_32_24.

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Female Pattern Hair Loss (FPHL) is a common dermatological condition in women, often causing significant psychological distress. The role of genetic factors, particularly single nucleotide polymorphisms (SNPs) in the cytochrome P450 (CYP19A1) gene, has been a subject of interest but has not been extensively studied in Egyptian populations. Hence, this study aimed to investigate the association between specific SNPs in the CYP19A1 gene (rs184895853 and rs116904472) and FPHL in an Egyptian population. This case-control study was conducted on 180 unrelated women (120 patients with FPHL and 60 hea

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28

Lee, Lifa, Hiromi Asada, Fumie Kizuka, et al. "Changes in Histone Modification and DNA Methylation of the StAR and Cyp19a1 Promoter Regions in Granulosa Cells Undergoing Luteinization during Ovulation In Rats." Endocrinology 154, no. 1 (2013): 458–70. http://dx.doi.org/10.1210/en.2012-1610.

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The ovulatory LH surge induces rapid up-regulation of steroidogenic acute regulatory (StAR) protein and rapid down-regulation of aromatase (Cyp19a1) in granulosa cells (GCs) undergoing luteinization during ovulation. This study investigated in vivo whether epigenetic mechanisms including histone modifications are involved in the rapid changes of StAR and Cyp19a1 gene expression. GCs were obtained from rats treated with equine chorionic gonadotropin (CG) before (0 h) and after human (h)CG injection. StAR mRNA levels rapidly increased after hCG injection, reached a peak at 4 h, and then remained

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Ali, Ruba M., Svetlana V. Lomteva, Anzhela A. Aleksandrova, et al. "Differential expression of CYP19A1 and lncRNA-CTBP1-AS in the granulosa cells of women with polycystic ovary syndrome." Research Results in Biomedicine 10, no. 2 (2024): 292–302. http://dx.doi.org/10.18413/2658-6533-2024-10-2-0-9.

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Background: Hyperandrogenism is the basic indicator of polycystic ovarian syndrome (PCOS) and a key factor in its pathological processes. Patients with PCOS have higher testosterone levels along with a decline in the estradiol/testosterone ratio, which may indicate an aromatase dysfunction. The aim of the study: Investigating the expression levels of CYP19A1 and lncRNA-CTBP1-AS in the granulosa cells (GCs) of women with and without PCOS. Materials and methods: We compared the expression levels of CYP19A1 and lncRNA-CTBP1-AS in granulosa cells from 16 PCOS patients and 20 controls who underwent

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Casteleiro Alves, Maria Manuel, Micaela Almeida, António Hélio Oliani, Luiza Breitenfeld, and Ana Cristina Ramalhinho. "CYP19A1 TC/CC Polymorphism, along with Deletion of GSTM1 and GSTT1 Genes, Strongly Influences Female Infertility Risk." Antioxidants 12, no. 4 (2023): 940. http://dx.doi.org/10.3390/antiox12040940.

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Oxidative stress has a fundamental role in the pathophysiology of various conditions, like infertility. This case-control study was performed to assess the potential role of CYP19A1, GSTM1, and GSTT1 in modifying individual predisposition to female infertility. Genotyping of 201 women with established infertility and 161 fertile female controls was performed, and statistical associations were analyzed. For carriers of GSTM1 null genotype along with CYP19A1 C allele, there is a significant association with female infertility risk (OR 7.023; 95% CI (3.627–13.601; p < 0.001), and, also for car

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Costermans, N. G. J., N. M. Soede, F. van Tricht, et al. "Follicular fluid steroid profile in sows: relationship to follicle size and oocyte quality†." Biology of Reproduction 102, no. 3 (2019): 740–49. http://dx.doi.org/10.1093/biolre/ioz217.

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Abstract Identification of reliable characteristics of follicle quality and developmental competence has been pursued in numerous studies, but with inconsistent outcomes. Here, we aimed to identify these characteristics by analysis of the follicular fluid (FF) steroid profile in relation to cumulus-oocyte complex (COC) morphology and follicle size, followed by molecular substantiation. Multiparous sows at weaning were used to facilitate analysis at the start of the follicular phase of the oestrus cycle. Sows with a higher average follicle size (≥5 mm vs. &lt; 5 mm) had a higher follicular

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Desmawati, Elis. "Hubungan Polimorfisme Gen Cyp19A1 dengan Kejadian Polycystic Ovarian Syndrome." Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal 13, no. 4 (2023): 1161–68. http://dx.doi.org/10.32583/pskm.v13i4.1204.

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Polycystic Ovarian Syndrome ialah interaksi dari faktor genetik dan faktor lingkungan yang berhubungan dengan sistem reproduksi sehingga dapat meningkatkan infertilitas dan gangguan metabolisme pada wanita reproduktif. Maka dari itu, penelitian ini dilakukan untuk mengetahui hubungan polimorfisme gen CYP19A1 dengan Kejadian PCOS pada wanita usia reproduktif di sumatera selatan. Jenis penelitian secara statistic observasional analitik dengan desain case control, sampel DNA pada pasien PCOS Kasus dan Kontrol diambil secara total sampling masing-masing sebanyak 36 sampel dilakukan dengan tekhnik

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Fukami, Maki, Takayoshi Tsuchiya, Heike Vollbach, et al. "Genomic Basis of Aromatase Excess Syndrome: Recombination- and Replication-Mediated Rearrangements Leading to CYP19A1 Overexpression." Journal of Clinical Endocrinology & Metabolism 98, no. 12 (2013): E2013—E2021. http://dx.doi.org/10.1210/jc.2013-2520.

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Context: Genomic rearrangements at 15q21 have been shown to cause overexpression of CYP19A1 and resultant aromatase excess syndrome (AEXS). However, mutation spectrum, clinical consequences, and underlying mechanisms of these rearrangements remain to be elucidated. Objective: The aim of the study was to clarify such unsolved matters. Design, Setting, and Methods: We characterized six new rearrangements and investigated clinical outcome and local genomic environments of these rearrangements and of three previously reported duplications/deletions. Results: Novel rearrangements included simple du

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Smolarz, Beata, Tomasz Szaflik, Hanna Romanowicz, and Krzysztof Szyłło. "Polymorphisms in the 3 ′ UTR Region of ESR2 and CYP19A1 Genes and Its Influence on Allele-Specific Gene Expression in Endometriosis." Disease Markers 2020 (December 1, 2020): 1–7. http://dx.doi.org/10.1155/2020/8845704.

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Objectives. Endometriosis is supported by hormonal, immunological, and environmental factors. No specific marker for endometriosis has yet been identified. ESR2 and CYP19A1 genes play a major role in the hormonal control of endometriosis women, the development of which largely depends on steroid hormones. Aim. An analysis of ESR2 and CYP19A1 allele-specific gene expressions in the context of the risk for endometriosis occurrence. Methods. The study material included paraffin-embedded tissue specimens, collected from patients ( n = 100 ) with endometriosis. Blood samples from age-matched, endom

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Oh, Jong-Nam, Jae Yeon Hwang, Kwang-Hwan Choi, and Chang-Kyu Lee. "Treatment of aromatase (CYP19A1) inhibitor reduces fertility in porcine sperm." Zygote 24, no. 1 (2015): 98–106. http://dx.doi.org/10.1017/s0967199414000781.

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SummaryTo ascertain whether aromatase (CYP19A1) expression is linked to sperm fertility of pigs, the present study determined the expression of the CYP19A1 gene in porcine sperm and its relationship with fertilization in vitro. First, to investigate its role in fertility, the presence of CYP19A1 of mRNA and protein expression in porcine sperm were confirmed by real-time (RT) or quantitative polymerase chain reaction (q-PCR) and by western blots. The expression levels were determined quantitatively using two sperm groups recovered by a Percoll gradient, which revealed that the sperm group with

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Dewaele, Aurélie, Emilie Dujardin, Marjolaine André, et al. "Absence of Testicular Estrogen Leads to Defects in Spermatogenesis and Increased Semen Abnormalities in Male Rabbits." Genes 13, no. 11 (2022): 2070. http://dx.doi.org/10.3390/genes13112070.

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Estrogens are steroid hormones produced by the aromatization of androgens by the aromatase enzyme, encoded by the CYP19A1 gene. Although generally referred to as “female sex hormones”, estrogen is also produced in the adult testes of many mammals, including humans. To better understand the function of estrogens in the male, we used the rabbit model which is an important biomedical model. First, the expression of CYP19A1 transcripts was localized mainly in meiotic germ cells. Thus, testicular estrogen appears to be produced inside the seminiferous tubules. Next, the cells expressing ESR1 and ES

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Kim, So-Sun, David Nahm-Joon Kim, Chang-Ju Lee, et al. "The Potential Sex Determination Genes, Sox9a and Cyp19a, in Walleye Pollock (Gadus Chalcogrammus) Are Influenced by Water Temperature." Journal of Marine Science and Engineering 8, no. 7 (2020): 501. http://dx.doi.org/10.3390/jmse8070501.

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Our aim was to study the relationship between the sex-determining genes, sox9a and cyp19a, and water temperature in Gadus chalcogrammus. We assessed the sex ratio based on the expression levels of sox9a and cyp19a at different water temperatures (5, 8, 11, and 14 °C) and at different stages of walleye pollock development (embryos, larvae, and juveniles). Next, we used immature walleye pollock to assess sox9a expression in males and cyp19a and vitellogenin (VTG) expression in females at different water temperatures. Males expressed sox9a in the gonadal tissues, while females expressed cyp19a in

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Wang, De-Shou, Tohru Kobayashi, Lin-Yan Zhou, et al. "Foxl2 Up-Regulates Aromatase Gene Transcription in a Female-Specific Manner by Binding to the Promoter as Well as Interacting with Ad4 Binding Protein/Steroidogenic Factor 1." Molecular Endocrinology 21, no. 3 (2007): 712–25. http://dx.doi.org/10.1210/me.2006-0248.

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Abstract Increasing evidence suggests the crucial role of estrogen in ovarian differentiation of nonmammalian vertebrates including fish. The present study has investigated the plausible role of Foxl2 in ovarian differentiation through transcriptional regulation of aromatase gene, using monosex fry of tilapia. Foxl2 expression is sexually dimorphic, like Cyp19a1, colocalizing with Cyp19a1 and Ad4BP/SF-1 in the stromal cells and interstitial cells in gonads of normal XX and sex-reversed XY fish, before the occurrence of morphological sex differentiation. Under in vitro conditions, Foxl2 binds t

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Kasielska-Trojan, Anna, Michał Pietrusiński, Magdalena Bugaj-Tobiasz, Jerzy Strużyna, Maciej Borowiec, and Bogusław Antoszewski. "Genetic Factors of Idiopathic Gigantomastia: Clinical Implications of Aromatase and Progesterone Receptor Polymorphisms." Journal of Clinical Medicine 11, no. 3 (2022): 642. http://dx.doi.org/10.3390/jcm11030642.

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The role of estrogen, progesterone, their receptors and aromatase in the development of the breast is well documented. In this study we examined the association of genetic variants of progesterone receptor (PGR) and aromatase (CYP19A1) genes with gigantomastia risk. We conducted a case-control study among 124 women: 60 with gigantomastia and 64 controls. We examined the single nucleotide polymorphisms (SNPs) for CYP19A1 (rs749292 and rs7172156) and PGR (rs1042838). Our results showed that allele G in rs749292 (CYP19A1) increased the risk of gigantomastia, but not significantly (p = 0.09). Ther

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Andric, Nebojsa, Mika Thomas, and Mario Ascoli. "Transactivation of the Epidermal Growth Factor Receptor Is Involved in the Lutropin Receptor-Mediated Down-Regulation of Ovarian Aromatase Expression in Vivo." Molecular Endocrinology 24, no. 3 (2010): 552–60. http://dx.doi.org/10.1210/me.2009-0450.

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Abstract Ovarian follicular development and differentiation is characterized by dramatic changes in aromatase (Cyp19a1) expression. In preovulatory follicles, activation of the FSH receptor increases aromatase expression until the surge of LH decreases it. Here we provide in vivo evidence that down-regulation of Cyp19a1 by the LH surge requires efficient signaling through the epidermal growth factor receptor (EGFR). The human chorionic gonadotropin (hCG)-induced down-regulation of Cyp19a1 expression in the two different mouse models with inactivating mutations of the EGFR (wa2 and velvet) is i

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Kuo, Fang-Ting, Kenneth Fan, Ikuko Bentsi-Barnes, Gillian M. Barlow, and Margareta D. Pisarska. "Mouse forkhead L2 maintains repression of FSH-dependent genes in the granulosa cell." REPRODUCTION 144, no. 4 (2012): 485–94. http://dx.doi.org/10.1530/rep-11-0259.

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The forkhead transcription factor forkhead box L2 (FOXL2) is expressed in granulosa cells of small and medium follicles in the mouse ovary.Foxl2female knockout mice exhibit primordial follicle depletion and primary ovarian failure, but evidence from adult female conditionalFoxl2knockout mice suggests that FOXL2 may also play a significant role in maintenance of ovarian differentiation at stages beyond the primordial follicle and initial wave of folliculogenesis. We previously showed that human FOXL2 functions as a transcriptional repressor of several key genes involved in granulosa cell prolif

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Fedulichev, P. N. "Polymorphisms in ESR1 and CYP19A1 genes in postmenopausal women with knee osteoarthritis." Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH) 14, no. 3 (2024): 15–20. http://dx.doi.org/10.20340/vmi-rvz.2024.3.morph.1.

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Abstract (sommario):

To date, a number of studies have been carried out to investigate the role of polymorphisms in estrogen receptor (ESR) and aromatase (CYP19A1) genes in knee osteoarthritis. However, the obtained results are contradictory and are not sufficient to formulate final conclusions. Purpose of the study: to investigate the associations of the rs2234693 and rs9340799 polymorphisms in ESR1 gene and the rs2414096 and rs936306 polymorphisms in CYP19A1 gene with knee osteoarthritis in postmenopausal women. Material and methods. Molecular genetic studies were performed in 157 postmenopausal women with knee

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Liu, Guangzheng, Yixiu Peng, Zeyu Li, et al. "An Inducible CYP19A1 Excision Model for Sexual Differentiation in Chicken (Gallus gallus) via the CRSPIR/Cas9 System." Veterinary Sciences 12, no. 4 (2025): 296. https://doi.org/10.3390/vetsci12040296.

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Aromatase, a crucial enzyme for estrogen synthesis, plays a vital role in gender determination and differentiation. This study aimed to establish an inducible knockout model of the chicken CYP19A1 gene, which encodes aromatase, to support gender control in chickens. We selected the most efficient sgRNA target site and constructed an inducible knockout model based on the Tet-on system. The knockout efficiency reached 80% with 20 μg/mL DOX induction in vitro. The encapsulation of the plasmid with PEI and injection into eggs achieved a knockout efficiency of 45% in ovo. qRT-PCR analysis revealed

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Lunardi, G., L. Del Mastro, M. Serra, et al. "Plasma levels of estrone sulfate (ES) in postmenopausal women with breast cancer (BC) during letrozole (L) treatment: Association with single nucleotide polymorphisms (SNPs) of CYP19A1." Journal of Clinical Oncology 27, no. 15_suppl (2009): 555. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.555.

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555 Background: The CYP19A1 gene encodes aromatase, a key enzyme for estrogen biosynthesis. We investigated the association between four CYP19A1 SNPs, affecting different circulating estrogen levels (rs10046 C>T, rs4646 G>T, rs749292 C>T, rs727479 T>G), and suppression of plasma ES levels induced by 6 weeks (time needed to reach L steady-state concentrations) of L (25 mg/d). Methods: Patients were enrolled into a prospective, italian multi-centre trial (GIM5) testing the correlation of CYP19A1 SNPs with the efficacy of L adjuvant therapy, after 5 years of tamoxifen, in postmenopaus

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Liang, Ning, Yinglei Xu, Yimeng Yin та ін. "Steroidogenic Factor-1 Is Required for TGF-β3-Mediated 17β-Estradiol Synthesis in Mouse Ovarian Granulosa Cells". Endocrinology 152, № 8 (2011): 3213–25. http://dx.doi.org/10.1210/en.2011-0102.

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The TGF-β superfamily members are indicated to play key roles in ovarian follicular development, such as granulosa cell proliferation, estrogens, and progesterone production. However, little is known about the roles of TGF-β3 in follicular development. In this study, we found that TGF-β3 was predominantly expressed in granulosa cells of mouse ovarian follicles, and it significantly promoted 17β-estradiol (E2) release in a dose-dependent manner. The orphan nuclear receptor steroidogenic factor-1 (SF-1) was required in TGF-β3-induced Cyp19a1 (a key rate-limiting enzyme for estrogen biosynthesis)

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Baatjes, Karin, Armand Peeters, Micheal McCaul, et al. "CYP19A1 rs10046 Pharmacogenetics in Postmenopausal Breast Cancer Patients Treated with Aromatase Inhibitors: One-year Follow-up." Current Pharmaceutical Design 26, no. 46 (2020): 6007–12. http://dx.doi.org/10.2174/1381612826666200908141858.

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Background: Significant individual variation in bone loss associated with aromatase inhibitors (AIs) emphasizes the importance of identifying postmenopausal breast cancer patients at high risk for this adverse effect. The study explores the clinical relevance of genetic variation in the Cytochrome P450 19A1 (CYP19A1) gene in a subset of South African patients during the first year of taking AIs for estrogen receptor (ER)-positive breast cancer. Methods: The study population consisted of ER-positive breast cancer patients on AIs, followed in real-life clinical practice. Body mass index was meas

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Villareal, Reina, Angela W. Meisner, Lina Aguirre, et al. "Association of CYP19A1 gene variants with differences in disease progression in breast cancer patients from different racial/ethnic backgrounds." Journal of Clinical Oncology 30, no. 15_suppl (2012): 1558. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.1558.

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Abstract (sommario):

1558 Background: Polymorphisms in the aromatase (CYP19A1) gene result in differences in the risk for breast cancer and response to treatment. We hypothesize that allele frequencies in the CYP19A1 gene vary according to race and may result in differences in progression of breast cancer among women from different racial backgrounds. The objectives of this study are: 1) to determine the allele/genotype frequencies in the CYP19A1 gene among women with breast cancer from different racial backgrounds, and, 2) to determine the association between disease progression and CYP19A1 gene variants. Methods

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Furuya, Toshiki, and Kuniki Kino. "Regioselective oxidation of indole- and quinolinecarboxylic acids by cytochrome P450 CYP199A2." Applied Microbiology and Biotechnology 85, no. 6 (2009): 1861–68. http://dx.doi.org/10.1007/s00253-009-2207-1.

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Uzar, Izabela, Anna Bogacz, Elżbieta Sowińska-Przepiera, et al. "Association of the CYP19A1 rs700518 Polymorphism with Selected Markers of Bone Metabolism in Women with Hyperandrogenism." Journal of Clinical Medicine 11, no. 12 (2022): 3537. http://dx.doi.org/10.3390/jcm11123537.

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Abstract (sommario):

Hyperandrogenism is the most common endocrine disorder in women, characterized by an imbalance of normal estrogen and androgen levels in the blood. Androgens play an important role in the female body because they influence bone mineral density (BMD), body mass composition, muscle mass, mental state, and the regulation of sexual function. The reduced activity of aromatase, due to mutations in the CYP19A1 gene, reduces the estrogen pool in favor of androgens. Clinically, aromatase deficiency causes hyperandrogenism in women. Therefore, the aim of the study was to assess the effect of the CYP19A1

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Rodríguez Castaño, Parween, and Pandey. "Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway." International Journal of Molecular Sciences 20, no. 18 (2019): 4606. http://dx.doi.org/10.3390/ijms20184606.

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Turmeric, a popular ingredient in the cuisine of many Asian countries, comes from the roots of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric is rich in curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have potent wound healing, anti-inflammatory, and anti-carcinogenic activities. While curcuminoids have been studied for many years, not much is known about their effects on steroid metabolism. Since many anti-cancer drugs target enzymes from the steroidogenic pathway, we tested the effect of curcuminoids on cytoc

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