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Tesi sul tema "Damage function"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 2 febbraio 2022

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1

Byrne, Christopher. "Muscle function after exercise-induced muscle damage." Thesis, Bangor University, 2001. https://research.bangor.ac.uk/portal/en/theses/muscle-function-after-exerciseinduced-muscle-damage(2bbf5fe1-f35b-4b7b-9790-ff3a04b86875).html.

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Muscle function after exercise-induced muscle damage has traditionally been evaluated by measures of isometric strength at a single joint angle or muscle length. The thesis investigates the effect of muscle damage on other muscle function parameters such as, isometric strength as a function of muscle length, concentric strength as a function of angular velocity, strength across muscle actions, the stretch-shortening cycle, power output, and fatigability. Study 1 The first part of this study aimed to determine how the muscle length at which strength is measured affects reductions in isometric s

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2

Ohtsuki, Akimichi. "Organic Chemical Approaches to DNA Function and Damage." 京都大学 (Kyoto University), 2011. http://hdl.handle.net/2433/142392.

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3

Li, Xiaoling. "Investigation of tissue transglutaminase function in apoptosis." Thesis, Nottingham Trent University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251281.

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4

Karras, Georgios Ioannis. "Mechanism and function of RAD6-mediated DNA damage tolerance." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-129233.

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5

Nafria, Javier Garcia. "Structure-function studies on proteins involved in DNA damage prevention." Thesis, University of York, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547327.

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6

Burrage, Joseph. "Analysis of the function of LSH in DNA damage repair." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/9416.

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DNA damage from both normal metabolic activities and environmental factors such as UV and radiation can cause as many as 1 million individual lesions to the DNA per cell per day (Lodish et al 2004). Cells respond to this continuous damage by employing many, highly efficient DNA repair mechanisms and undergo apoptosis when normal DNA repair fails. Of the many types of DNA damage that can occur, double strand breaks (DSBs) are the most toxic (Featherstone & Jackson 1999). A single unrepaired DSB is enough to induce cellular apoptosis and several mechanisms have developed to repair DSBs. The reco

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7

Maisse, Carine. "Regulation and function of the DeltaNp73 isoforms after DNA damage." Paris 6, 2004. http://www.theses.fr/2004PA066598.

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Les cellules d’un organisme subissent chaque jour des stress dus à l’environnement (rayons UV, agents chimiques, métaux lourds) pouvant conduire à des lésions du patrimoine génétique ou à un déséquilibre de l’état RedOx. De nombreux systèmes cellulaires permettent tout d’abord d’identifier le dommage puis d’induire éventuellement la réparation de l’ADN ou la mort de la cellule si le dommage subi est irréversible. Une cellule cancéreuse est le résultat d’échecs cumulés des systèmes de contrôle intra et extra-cellulaires et de mort programmée. Identifiée en 1979, la protéine p53 est un facteur d

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8

De, Moura Miguez Araujo Sofia Jorge. "Interactions and function of nucleotide excision repair protein complexes." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322320.

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9

Zhang, Muyu [Verfasser], Bernd [Akademischer Betreuer] Markert, and Rüdiger [Akademischer Betreuer] Schmidt. "Auto-correlation-function-based damage index for damage detection and system identification / Muyu Zhang ; Bernd Markert, Rüdiger Schmidt." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1130327329/34.

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10

Chapman, J. R. "Molecular analysis of mediator-protein function in the DNA damage response." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597474.

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I report the identification of phosphorylation sites in MDC1 that are phosphorylated by ATM in response to ionizing radiation (IR), and demonstrates that these motifs are required for the efficient recruitment of BRCA1 and 53BP1 into IRIF. We identified the E3 Ubiquitin ligase RNF8 as critical for this process, and show that upon phosphorylation, these MDC1 sites are bound directly by the FHA domain of RNF8, directing it to generate ubiquitinated proteins at DSB sites. We demonstrate that it is the formation of these ubiquitin conjugates at DSB sites that facilitate BRCA1 and 53BP1 recruitment

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11

Twigg, Jeremy Philip. "DNA damage in human spermatozoa : free radicals, sperm function and ICSI." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391610.

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12

Hurley, Michael V. "Muscle function, inhibition and rehabilitation following traumatic and degenerative joint damage." Thesis, King's College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321690.

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13

Xie, Jenny X. "Regulation of BACH1/FANCJ Function in DNA Damage Repair: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/435.

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The DNA damage response (DDR) pathway is a complicated network of interacting proteins that function to sense and remove DNA damage. Upon exposure to DNA damage, a signaling cascade is generated. The damage is either removed, restoring the original genetic sequence, or apoptosis is activated. In the absence of DDR, cells are unable to effectively process DNA damage. Unprocessed DNA damage can lead to chromosomal changes, gene mutations, and malignant transformation. Thus, the proteins involved in DDR are critical for maintaining genomic stability. One essential DDR protein is the BRCA1 Associa

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14

Smith, Peter Alan. "A study of the transient effects of high energy laser light on visual function." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243277.

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15

Kysela, Boris. "Ionizing radiation-induced DNA damage and repair in relation to biological function." Thesis, Brunel University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384841.

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16

Archer, Sophie. "Innate immune cell migration and function in response to damage associated signals." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665383.

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Tissue damage initiates the release of a complex, interacting collection of chemical signals. The coordinated function of these signals gives rise to an inflammatory event, whereby circulating immune cells are recruited to clear pathogens. Invertebrate models of tissue damage have revealed a key role for damage-associated signals, specifically hydrogen peroxide (H2O2), in attracting immune cells to sites of tissue damage. The Src family kinase (SFK), Lyn, is oxidised by H2O2 in zebrafish wound models, and subsequent activation of Lyn triggers directed cell motility. In mammalian systems, H2O2

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17

Hill, Sarah J. "Familial ALS Proteins Function in Prevention/repair of Transcription-Associated DNA Damage." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:27007760.

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Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron dysfunction disease that leads to paralysis and death. There is currently no defined molecular pathogenesis pathway. Multiple proteins involved in RNA processing are linked to ALS, including FUS and TDP43; and we propose a disease mechanism in which loss of function of one of these proteins leads to an accumulation of transcription-associated DNA damage contributing to motor neuron cell death and progressive neurological symptoms. In support of this hypothesis, we found that depletion of FUS and TDP43 leads to increased se

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18

Ninic, Dejan Mechanical &amp Manufacturing Engineering Faculty of Engineering UNSW. "Fatigue in automatic transmissions." Awarded by:University of New South Wales. School of Mechanical and Manufacturing Engineering, 2006. http://handle.unsw.edu.au/1959.4/28056.

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A novel method of predicting the multiaxial high-cycle fatigue strength of metallic components is proposed and verified for various steel, aluminium and cast iron alloys. The proposed Fatigue Damage Function shows superior multiaxial fatigue strength prediction compared to the established methods of Gough and Pollard, McDiarmid and Carpinteri and Spagnoli. A new material property, the Normal Stress Sensitivity Factor, is also introduced and its applicability is verified according to published test results of sixteen different structural alloys. To highlight the effectiveness of the proposed cr

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19

Kennedy, Jessica Ashley. "Structure-Function Analysis of the DNA Damage Repair Complex STR in Saccharomyces cerevisiae." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5713.

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The RecQ family of helicases has been termed the “Caretakers of the Genome,” and rightfully so. These proteins are highly conserved from bacteria to humans and have been implicated in functions from homologous recombinatorial repair to damage checkpoint response to telomere maintenance and more. Mutant genes of three of the human RecQ helicases lead to syndromes characterized by a high incidence of cancer, premature aging and early death. Despite their implications in several biological functions and importance to the integrity of the human genome and suppression of cancer, many aspects of the

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20

Ajina, Sara. "Changes in connectivity, structure and function following damage to the primary visual cortex." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:2e274261-c71a-4ad1-82cf-2fe6bbdbf673.

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Residual vision, or blindsight, following damage to the primary visual cortex was first identified almost a century ago. However, the mechanism and pathways underlying this ability, as well as the extent of visual function, remain unclear and are a continuing source of speculation. The work presented here goes some way to try to address these questions, investigating 18 patients with V1 damage and homonymous visual field loss acquired in adulthood. Six experimental chapters explore the extent and potential for visual function after V1 damage, and apply novel neuroimaging paradigms and techniqu

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21

Maisel, Simon F. "Repetitive anodal tDCS of perilesional cortex impairs recovery of function after parietal damage." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12501.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Unilateral spatial neglect is a common disorder, most often occurring after right hemispheric stroke and resulting in severe functional impairment and a poor prognosis of recovery. Previous research has shown th

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22

Barr, Alexis. "Characterising the function of CDK5RAP2 in the vertebrate centrosome." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/228639.

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The centrosome is the major microtubule organising centre in vertebrate cells. CDK5RAP2 is a human protein that localises to the centrosome. At the start of this thesis work, the function of CDK5RAP2 was uncharacterised. Significantly, cdk5rap2 is one of several centrosomal genes that are mutated in the developmental disorder Primary Microcephaly, where affected individuals have smaller brains than expected for the age- and sex-adjusted mean. Orthologues of CDK5RAP2 in the fruit fly (Centrosomin/Cnn) and in fission yeast (Mod20p) have been well characterised and are known to have important rol

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23

Cromie, Lillian. "The influence of reactive oxygen species on human lymphoid cell function in vitro." Thesis, University of Ulster, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281431.

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24

Brooks, William Samuel. "Localization and function of G2E3." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/brooks.pdf.

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25

Gürler, Hakan [Verfasser]. "Effects of cryopreservation on mitochondrial function and DNA damage of bovine sperm / Hakan Gürler." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/104671029X/34.

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26

Ghospurkar, Padmaja Laxman. "Characterization of RPA2 N-terminal Function in the DNA Damage Response in Saccharomyces Cerevisiae." Diss., North Dakota State University, 2015. http://hdl.handle.net/10365/24843.

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In response to DNA damage, two general but fundamental processes occur in the cell: (1) a DNA lesion is recognized and repaired, and (2) concomitantly, the cell halts the cell cycle to provide a window of opportunity for repair to occur. A key factor involved in the DNA damage response is the heterotrimeric protein complex Replication Protein A (RPA), which is not only essential for the repair of damaged DNA, but also is post-translationally modified on at least two of the three subunits in response to DNA damage by checkpoint kinases. Of particular interest is the 32-kDa subunit, called Rpa2,

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27

Lomax, Martine Elizabeth. "The evaluation of p53 function in cells from members of cancer prone families." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298202.

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28

Zhang, Fang. "Flood Damage and Vulnerability Assessment for Hurricane Sandy in New York City." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1374108651.

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29

Ochodnický, Peter. "Vascular endothelial and myogenic function in renal disease focus on individual susceptibility to organ damage /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/289761514.

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30

Silva, Garcia Maria [Verfasser]. "A novel function of DPP9 in DNA damage repair via BRCA2 regulation / Maria Silva Garcia." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1222264986/34.

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31

Levadoux, Marilyne. "A novel approach to the study of metallothionein function in oxidative stress and DNA damage." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323398.

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Metallothioneins (MTs) have a major role in metal metabolism and may also protect DNA against oxidants. MT protein has been found localized in the nucleus during S-phase. The mRNA encoding for the MT-1 isoform is found localized around the nucleus and associated with the cytoskeleton; this is due to targeting signals within the 3'untranslated region (3'UTR). Using cells transfected with gene constructs differing in their 3'UTRs, the role of perinuclear mRNA localization in facilitating MT synthesis close to its site of function and subsequent import of protein into the nucleus has been investi

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32

Bennett, Brian Thomas. "Human Rad51: Regulation of Cellular Localization and Function in Response to DNA Damage: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/224.

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Repair of DNA double-strand breaks via homologous recombination is an essential pathway for vertebrate cell development and maintenance of genome integrity throughout the organism’s lifetime. The Rad51 enzyme provides the central catalytic function of homologous recombination while many other proteins are involved in regulation and assistance of Rad51 activity, including a group of five proteins referred to as Rad51 paralogs (Rad51B, Rad51C, Rad51D, Xrcc2, Xrcc3). At the start of my work, cellular studies of human Rad51 (HsRad51) had shown only that it forms distinct nuclear foci in response t

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33

Macabuag, Joshua. "Tsunami damage prediction for buildings : development of methods for empirical and analytical fragility function derivation." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10047419/.

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Over the past two decades, tsunami have been the cause of 33% of total deaths and 35% of total economic losses due to natural disasters globally, and currently 6 out of 10 of the most populous megacities in the world are at risk of being severely affected by tsunami. Quantifying tsunami risk is therefore centrally important for land use and emergency planning in the DRR sector, for human and financial loss estimation in the insurance sector, and for performance-based design in the engineering sector. Tsunami fragility functions are statistical models that relate a measure of tsunami intensity

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34

Yang, Yu-Ying. "The Effects of Exogenous Ubiquinone on Mitochondrial Function, Oxidative Damage, and Lifespan in Caenorhabditis elegans." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1278098162.

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35

Croft, Richard P. "The epidemiology, risk factors and response to treatment by corticosteroids of acute nerve function impairment in leprosy." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325251.

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36

Can, Geylani. "S-phase checkpoint activity and function throughout the cell cycle." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/268506.

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DNA damage or replication stress during S-phase can activate the S-phase checkpoint which executes a variety of responses, such as the inhibition of origin firing and replication fork stabilisation. Deregulation of the S-phase checkpoint leads to genomic instability, which has been implicated in diseases such as cancer. In this thesis, I aimed to address whether the S-phase checkpoint is regulated outside of S-phase, and how the S-phase checkpoint targets its substrates in budding yeast. Although this checkpoint has thus far been associated exclusively with S-phase, it remains unknown whether

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37

Miller, Halie Kay. "Characterization of the Lone Extracytoplasmic Function Sigma Factor, óS, and its Role in the Staphylococcus aureus Virulence and Stress Responses." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4164.

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Previously our laboratory had identified a novel component of the Staphylococcus aureus regulatory network, an extracytoplasmic function ó factor, óS, involved in stress response and disease causation. Here we present additional characterization of óS, demonstrating a role for it in protection against DNA damage, cell wall disruption and interaction with components of the innate immune system. Promoter mapping reveals the existence of four unique sigS start sites, one of which appears to be subject to auto-regulation. Transcriptional profiling revealed that sigS expression remains low in a

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38

Navarro, Serer Judith 1990. "Understanding functional interplay between PARP-1 and PARP-2 in T cell development and function." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/481994.

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T-cell homeostasis must be tightly regulated and maintained in order to guarantee appropriate immune responses and prevent immunopathology. This maintenance depends on MHC-TCR interaction and cytokine-mediated signals among others. However, cell intrinsic factors that modulate essential functions in T-cells must be also integrated to support genomic stability and contribute to the control of T-cell homeostasis. The present work establishes a coordinated role of poly (ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function, demonstrated by the defective

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39

Pessoa-Brandão, Luis. "Genetic and molecular studies of Saccharomyces cerevisiae Cdc7-Dbf4 kinase function in DNA damage-induced mutagenesis /." Connect to full text via ProQuest. IP filtered, 2005.

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40

Angelin, Karinne Ansiliero. "Dano injusto como pressuposto do dever de indenizar." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/2/2131/tde-10012014-073936/.

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O objetivo desta dissertação é demonstrar que a responsabilidade civil aquiliana, no ordenamento jurídico brasileiro, tem como pressuposto fundamental a causação de dano injusto. Esse objetivo justifica-se porque existem posições doutrinárias, conhecidas como direito de danos, que defendem a desnecessidade do dano injusto para que seja deflagrada a estrutura de responsabilização civil. Analisam-se, para tanto, a estrutura e a finalidade da responsabilidade civil, bem como o seu enquadramento no sistema jurídico brasileiro.<br>The aim of this dissertation is to show that the non-contractual civ

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41

Hass, Cathy Staloch. "Function of Replication Protein A in DNA repair and cell checkpoints." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2515.

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Replication Protein A (RPA), the major eukaryotic single-strand DNA (ssDNA) binding protein, is essential for replication, repair, recombination, and checkpoint activation. Defects in RPA-associated cellular activities lead to genomic instability, a major factor in the pathogenesis of cancer. The ssDNA-binding activity of RPA is primarily mediated by two domains in the RPA1 subunit. I characterized mutant forms of RPA to elucidate the contribution of specific residues in the high affinity DNA binding domains to the cellular function of RPA. These studies enhance the understanding of the proper

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42

Grauer, Christine M. "The effects of zinc status on hepatic poly(ADP-ribose) polymerase function in response to DNA damage." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq24472.pdf.

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43

Befroy, Douglas Eugene. "Osmotic shock : modulation of contractile function, pHâ†i and ischaemic damage in the perfused guinea-pig heart." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326024.

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44

Li, Kai. "Regulation of WRN Function by Acetylation and SIRT1-Mediated Deacetylation in Response to DNA Damage: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/511.

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Werner syndrome (WS) is an autosomal recessive disorder associated with premature aging and cancer predisposition. WS cells show increased genomic instability and are hypersensitive to DNA-damaging agents. WS is caused by mutations of the WRN gene. WRN protein is a member of RecQ DNA helicase family. In addition to a conserved 3’–5’ helicase activity, the WRN protein contains unique 3’–5’ exonuclease activity. WRN recognizes specific DNA structures as substrates that are intermediates of DNA metabolism. WRN physically and functionally interacts with many other proteins that function in telomer

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45

Taura, Akiko. "Recovery of hair cell function after damage induced by gentamicin in organ culture of rat vestibular maculae." Kyoto University, 2007. http://hdl.handle.net/2433/135651.

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46

Farukh, Farukh. "Experimental and numerical analysis of deformation and damage in thermally bonded nonwoven material." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/12812.

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47

Grahn, Tonje. "Risk assessment of natural hazards : Data availability and applicability for loss quantification." Doctoral thesis, Karlstads universitet, Institutionen för miljö- och livsvetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-48324.

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Quantitative risk assessments are a fundamental part of economic analysis and natural hazard risk management models. It increases the objectivity and the transparency of risk assessments and guides policymakers in making efficient decisions when spending public resources on risk reduction. Managing hazard risks calls for an understanding of the relationships between hazard exposure and vulnerability of humans and assets. The purpose of this thesis is to identify and estimate causal relationships between hazards, exposure and vulnerability, and to evaluate the applicability of systematically

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48

Lozada, Santiago Enerlyn Meliza. "GENOTOXIN-INDUCED ACETYLATION OF THE WERNER SYNDROME PROTEIN (WRN) AND EFFECT ON ITS DNA METABOLIC FUNCTION." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/817.

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Loss of function of the WRN protein causes the genetic disorder Werner Syndrome that is characterized by increased cancer and premature aging. WRN belongs to the RecQ helicase family that plays key roles in preventing genome instability. In response to treatment with genotoxins, WRN is subject to post-translational modification. The relationship of post-translational modification of WRN with its function in DNA metabolism is unknown. There is accumulating evidence suggesting that WRN contributes to the maintenance of genomic integrity through its involvement in DNA replication. Consistent with

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49

Frey, Erin N. "ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1365777374.

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50

Powers, Kyle Thomas. "Structure and function of the disordered regions within translesion synthesis DNA polymerases." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6625.

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Normal DNA replication is blocked by DNA damage in the template strand. Translesion synthesis is a major pathway for overcoming these replication blocks. In this process, multiple non-classical DNA polymerases form a complex at the stalled replication fork called the mutasome. This complex is structurally organized by the replication accessory factor PCNA and the non-classical DNA polymerase Rev1. One of the non-classical DNA polymerases within the mutasome then catalyzes replication through the damage. Each non-classical DNA polymerase has one or more cognate lesions, which the enzyme bypasse

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