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Tesi sul tema "Dependence modelling"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 19 febbraio 2022

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1

Taku, Marie Manyi. "Modelling Dependence of Insurance Risks." Thesis, Linnéuniversitetet, Institutionen för datavetenskap, fysik och matematik, DFM, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-9064.

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Abstract (sommario):
Modelling one-dimensional data can be performed by different wellknown ways. Modelling two-dimensional data is a more open question. There is no unique way to describe dependency of two dimensional data. In this thesis dependency is modelled by copulas. Insurance data from two different regions (Göinge and Kronoberg) in Southern Sweden is investigated. It is found that a suitable model is that marginal data are Normal Inverse Gaussian distributed and copula is a better dependence measure than the usual linear correlation together with Gaussian marginals.
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2

Lecei, Ivan [Verfasser]. "Modelling extremal dependence / Ivan Lecei." Ulm : Universität Ulm, 2018. http://d-nb.info/1173249745/34.

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3

Johnson, Jill Suzanne. ""Modelling Dependence in Extreme Environmental Events"." Thesis, University of Newcastle upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525050.

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4

Yu, Lanhua. "Risk management : modelling dependence between asset returns." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420966.

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5

Navarrete, Miguel A. Ancona. "Dependence modelling and spatial prediction for extreme values." Thesis, Lancaster University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369658.

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6

Kereszturi, Monika. "Assessing and modelling extremal dependence in spatial extremes." Thesis, Lancaster University, 2017. http://eprints.lancs.ac.uk/86369/.

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Abstract (sommario):
Offshore structures, such as oil platforms and vessels, must be built such that they can withstand extreme environmental conditions (e.g., high waves and strong winds) that may occur during their lifetime. This means that it is essential to quantify probabilities of the occurrence of such extreme events. However, a difficulty arises in that there are very limited data available at these levels. The statistical field of extreme value theory provides asymptotically motivated models for extreme events, hence allowing extrapolation to very rare events. In addition to the risk to a single site, we
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7

Menguturk, Levent Ali. "Information-based jumps, asymmetry and dependence in financial modelling." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/10953.

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In mathematical finance, economies are often presented with the specification of a probability space equipped with a filtration that encodes information flow. The information-based framework of Brody, Hughston and Macrina (BHM) emphasises the role of market information in deriving asset price dynamics, instead of assuming price behaviour from the start. We extend the BHM framework by (i) modelling the nature of access to information through information blockages and activations of new information sources, and (ii) introducing a new class of multivariate Markov processes that we call Generalise
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8

Carreira, Inês Duarte. "Modelling dependence between frequency and severity of insurance claims." Master's thesis, Instituto Superior de Economia e Gestão, 2017. http://hdl.handle.net/10400.5/14631.

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Mestrado em Actuarial Science<br>A estimação da perda individual é uma importante tarefa para calcular os preços das apólices de seguro. A abordagem padrão assume independência entre a frequência e a severidade dos sinistros, o que pode não ser uma suposição realística. Neste texto, a dependência entre números e montantes de sinistros é explorada, num contexto de Modelos Lineares Generalizados. Um modelo de severidade condicional e um modelo de Cópula são apresentados como alternativas para modelar esta dependência e posteriormente aplicados a um conjunto de dados fornecido por uma seguradora
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9

Werner, Christoph. "Structured expert judgement for dependence in probabilistic modelling of uncertainty : advances along the dependence elicitation process." Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=30519.

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In decision and risk analysis problems, modelling uncertainty probabilistically provides key insights and information for decision makers. A common challenge is that uncertainties are typically not isolated but interlinked which introduces complex (and often unexpected) effects on the model output. Therefore, dependence needs to be taken into account and modelled appropriately if simplifying assumptions, such as independence, are not sensible. Similar to the case of univariate uncertainty, relevant historical data to quantify a (dependence) model are often lacking or too costly to obtain. This
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10

Xia, Xinghua. "Essays on dependence modelling with vine copulas and its applications." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42235.

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This thesis contains three essays on dependence modelling with high dimension vine copulas and its applications in credit portfolio risk, asset allocation and international financial contagion. In the first essay, we demonstrate the superiority of vine copulas over multivariate Gaussian copula when modelling the dependence structure of a credit portfolio risk factors. We introduce the vine copulas to modelling the dependence structure of multi risk factors log returns in the combined framework of both threshold model and mixture model credit risk modelling. The second essay studies asset alloc
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11

Abadi, Mostafa Shams Esfand. "Analysis of new techniques for risk aggregation and dependence modelling." Master's thesis, Instituto Superior de Economia e Gestão, 2015. http://hdl.handle.net/10400.5/9239.

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Mestrado em Ciências Actuariais<br>In risk aggregation we are interested in the distribution of the sum of dependent risks. The objective of risk aggregation and dependence modeling is to model adequately dependent insurance portfolios in order to evaluate the overall risk exposure. This master thesis investigates some practical aspects of modeling risk aggregation and dependency. We give an introduction to copula-based hierarchical aggregation model through reordering algorithm. This approach can be easily applicable in high dimensions and consists of a tree structure, bivariate copulas, and
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12

Lundman, Josef. "Modelling Energy Dependence of Liquid Ionisation Chambers Using Fluence Pencil Kernels." Thesis, Umeå universitet, Radiofysik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53909.

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The high demand on accuracy in radiotherapy is to a large extent ensured through measurements of dose to water. The liquid ionisation chamber (LIC) is a type of detector that has several desirable properties for such measurements, e.g. a small active volume and minimal directional dependent response. There are, however, still gaps in knowledge concerning fundamental characteristics of this kind of detector. One of these characteristics is the detector’s response variation in relation to water with varying beam quality. This work aims to increase the knowledge of the LIC’s behaviour and attempt
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13

Backman, Fredrik. "Dependence Modelling and Risk Analysis in a Joint Credit-Equity Framework." Thesis, KTH, Matematisk statistik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168154.

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This thesis is set in the intersection between separate types of financial markets, with emphasis on joint risk modelling. Relying on empirical findings pointing toward the ex- istence of dependence across equity and corporate debt markets, a simulation framework intended to capture this property is developed. A few different types of models form building blocks of the framework, including stochastic processes describing the evolution of equity and credit risk factors in continuous time, as well as a credit rating based model, providing a mechanism for imposing dependent credit migrations and
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14

Deara, Mohamed Ahmed. "Replacement policies for a two-component system with failure dependence." Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366316.

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15

Oduneye, Chris Emeka. "Credit modelling : generating spread dynamics with intensities and creating dependence with copulas." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6910.

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The thesis is an investigation into the pricing of credit risk under the intensity framework with a copula generating default dependence between obligors. The challenge of quantifying credit risk and the derivatives that are associated with the asset class has seen an explosion of mathematical research into the topic. As credit markets developed the modelling of credit risk on a portfolio level, under the intensity framework, was unsatisfactory in that either: 1. The state variables of the intensities were driven by diffusion processes and so could not generate the observed level of default co
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16

Berg, Edvin, and Karl Wilhelm Lange. "Enhancing ESG-Risk Modelling - A study of the dependence structure of sustainable investing." Thesis, KTH, Matematisk statistik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-266378.

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The interest in sustainable investing has increased significantly during recent years. Asset managers and institutional investors are urged to invest more sustainable from their stakeholders, reducing their investment universe. This thesis has found that sustainable investments have a different linear dependence structure compared to the regional markets in Europe and North America, but not in Asia-Pacific. However, the largest drawdowns of an sustainable compliant portfolio has historically been lower compared to the a random market portfolio, especially in Europe and North America.<br>Intres
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17

Kosgodagan, Alex. "High-dimensional dependence modelling using Bayesian networks for the degradation of civil infrastructures and other applications." Thesis, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire, 2017. http://www.theses.fr/2017IMTA0020/document.

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Cette thèse explore l’utilisation des réseaux Bayésiens (RB) afin de répondre à des problématiques de dégradation en grandes dimensions concernant des infrastructures du génie civil. Alors que les approches traditionnelles basées l’évolution physique déterministe de détérioration sont déficientes pour des problèmes à grande échelle, les gestionnaires d’ouvrages ont développé une connaissance de modèles nécessitant la gestion de l’incertain. L’utilisation de la dépendance probabiliste se révèle être une approche adéquate dans ce contexte tandis que la possibilité de modéliser l’incertain est un
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18

Zugic, Richard. "Modelling the tribology of thin film interfaces." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365788.

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19

Aparicio, Acosta Felipe Miguel. "Nonlinear modelling and analysis under long-range dependence with an application to positive time series /." [S.l.] : [s.n.], 1995. http://library.epfl.ch/theses/?nr=1381.

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20

Labukhin, Dmitry Li Xun. "Modelling, design, and simulation of facet reflection and gain polarization dependence in semiconductor optical amplifiers." *McMaster only, 2007.

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21

Patta, Vaia. "Aspects of categorical physics : a category for modelling dependence relations and a generalised entropy functor." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:8bfd2a2d-524e-4ffa-953b-33d66ba186ed.

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Two applications of Category Theory are considered. The link between them is applications to Physics and more specifically to Entropy. The first research chapter is broader in scope and not explicitly about Physics, although connections to Statistical Mechanics are made towards the end of the chapter. Matroids are abstract structures that describe dependence, and strong maps are certain structure-preserving functions between them with desirable properties. We examine properties of various categories of matroids and strong maps: we compute limits and colimits; we find free and cofree constructi
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22

Santos, Mariana Faria dos. "Modelling claim counts of homogeneous risk groups using copulas." Master's thesis, Instituto Superior de Economia e Gestão, 2010. http://hdl.handle.net/10400.5/2932.

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Mestrado em Ciências Actuariais<br>Over the years modelling the dependence between random variables has been a challenge in many areas, like insurance and finance. Recently with the new capital requirement regime for the European insurance business, this subject is increasing importance since, according to Solvency II, the insurer's risks should be modelled separately, then aggregated follow¬ing some dependence structure. The challenge of this framework is to achieve an accurate way of joining dependent risks in order to not over or underestimate the capital require¬ments. The aim of this thes
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23

Forrest, Robyn Elizabeth. "Simulation models for estimating productivity and trade-offs in the data-limited fisheries of New South Wales, Australia." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/3417.

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Recent shifts towards ecosystem based fisheries management (EBFM) around the world have necessitated consideration of effects of fishing on a larger range of species than previously. Non-selective multispecies fisheries are particularly problematic for EBFM, as they can contribute to erosion of ecosystem structure. The trade-off between catch of productive commercial species and abundance of low-productivity species is unavoidable in most multispecies fisheries. A first step in evaluation of this trade-off is estimation of productivity of different species but this is often hampered by poor d
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24

Snguanyat, Ongorn. "Stochastic modelling of financial time series with memory and multifractal scaling." Queensland University of Technology, 2009. http://eprints.qut.edu.au/30240/.

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Financial processes may possess long memory and their probability densities may display heavy tails. Many models have been developed to deal with this tail behaviour, which reflects the jumps in the sample paths. On the other hand, the presence of long memory, which contradicts the efficient market hypothesis, is still an issue for further debates. These difficulties present challenges with the problems of memory detection and modelling the co-presence of long memory and heavy tails. This PhD project aims to respond to these challenges. The first part aims to detect memory in a large number of
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25

Rodríguez, Gasén Rosa. "Modelling SEP events: latitudinal and longitudinal dependence of the injection rate of shock-accelerated protons and their flux profiles." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/31855.

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Gradual SEP events is one of the greatest hazards in space environment, particularly for the launch and operation of spacecraft and for manned exploration. Predictions of their occurrence and intensity are essential to ensure the proper operation of technical and scientific instruments. However, nowadays there is a large gap between observations and models these events that can lead to predictions. This work focuses on the modelling of SEP events, particularly, on the influence of the observer's relative position and of the shock strength, on the simulated SEP flux profiles. Part I of the
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26

Kostet, Daniel. "Railway bridges with floating slab track systems : Numerical modelling of rail stresses - Dependence on properties of floating slab mats." Thesis, Luleå tekniska universitet, Byggkonstruktion och -produktion, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-67297.

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The increased use of continuously welded rails in the railway systems makes it necessary to increase the control of the rail stresses to avoid instability and damages of the rails. Large stresses are especially prone to appear at discontinuities in the railway systems, such as bridges, due to the interaction between the track and the bridge. The interaction leads to increased horizontal forces in the rails due to the changed stiffness between the embankment and the bridge, temperature variations, bending of the bridge structure because of vertical traffic loads and braking and traction forces.
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27

Salih, Sarmed. "Rate-dependent cohesive-zone models for fracture and fatigue." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/ratedependent-cohesivezone-models-for-fracture-and-fatigue(d8bfee97-1a75-4418-8916-b5a7cf8cdfd9).html.

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Despite the phenomena of fracture and fatigue having been the focus of academic research for more than 150 years, it remains in effect an empirical science lacking a complete and comprehensive set of predictive solutions. In this regard, the focus of the research in this thesis is on the development of new cohesive-zone models for fracture and fatigue that are afforded an ability to capture strain-rate effects. For the case of monotonic fracture in ductile material, different combinations of material response are examined with rate effects appearing either in the bulk material or localised to
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28

Gaigalas, Raimundas. "A Non-Gaussian Limit Process with Long-Range Dependence." Doctoral thesis, Uppsala : Matematiska institutionen, Univ. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3993.

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29

Tate, Catriona Mary. "Effect of probe-target sequence mismatches on the results of microarray hybridisations : position-dependence, modelling and impact of evolutionary distance." Thesis, University of Manchester, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529202.

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30

Griffith, Daniel, Manfred M. Fischer, and James P. LeSage. "The spatial autocorrelation problem in spatial interaction modelling: A comparison of two common solutions." Springer, 2017. http://epub.wu.ac.at/6032/1/spatial.pdf.

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Spatial interaction models of the gravity type are widely used to describe origin-destination flows. They draw attention to three types of variables to explain variation in spatial interactions across geographic space: variables that characterize the origin region of interaction, variables that characterize the destination region of interaction, and variables that measure the separation between origin and destination regions. A violation of standard minimal assumptions for least squares estimation may be associated with two problems: spatial autocorrelation within the residuals, and spatial au
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31

Pesee, Chatchai. "Stochastic Modelling of Financial Processes with Memory and Semi-Heavy Tails." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16057/.

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This PhD thesis aims to study financial processes which have semi-heavy-tailed marginal distributions and may exhibit memory. The traditional Black-Scholes model is expanded to incorporate memory via an integral operator, resulting in a class of market models which still preserve the completeness and arbitragefree conditions needed for replication of contingent claims. This approach is used to estimate the implied volatility of the resulting model. The first part of the thesis investigates the semi-heavy-tailed behaviour of financial processes. We treat these processes as continuous-t
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32

Sun, Huiling. "System dependency modelling." Thesis, Loughborough University, 2007. https://dspace.lboro.ac.uk/2134/34918.

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Abstract (sommario):
It is common for modern engineering systems to feature dependency relationships between its components. The existence of these dependencies render the fault tree analysis (FTA) and its efficient implementation, the Binary Decision Diagram (BDD) approach, inappropriate in predicting the system failure probability. Whilst the Markov method provides an alternative means of analysis of systems of this nature, it is susceptible to state space explosion problems for large, or even moderate sized systems. Within this thesis, a process is proposed to improve the applicability of the Markov analysis. W
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33

Essman, Carl. "Social preconditions of collective action among NGO:s : A social network analysis of the information exchanges between 55 NGO:s in Georgia." Thesis, Stockholms universitet, Sociologiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-118567.

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Individual shortcomings and the need for resources stimulates organizations desire to establish collaborative relations with each other. An organization tends to prefer to collaborate with other familiar organizations. The information available to an organization about its peers is necessary for its ability to appreciate the suitability of potential partners as well as their capabilities and ability to contribute to a successful collaborative relation. In a three stage analytical process, social network analysis and statistical network modelling is applied to investigate the correlation betwee
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34

Wollscheid, Daniel [Verfasser], Alexander [Akademischer Betreuer] Lion, and Leif [Akademischer Betreuer] Kari. "Predeformation and frequency dependence of filler-reinforced rubber under vibration : Experiments - Modelling - Finite Element Implementation / Daniel Wollscheid. Universität der Bundeswehr München, Fakultät für Luft- und Raumfahrttechnik. Gutachter: Alexander Lion ; Leif Kari. Betreuer: Alexander Lion." Neubiberg : Universitätsbibliothek der Universität der Bundeswehr München, 2014. http://d-nb.info/1071848372/34.

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35

Wollscheid, Daniel Verfasser], Alexander [Akademischer Betreuer] [Lion, and Leif [Akademischer Betreuer] Kari. "Predeformation and frequency dependence of filler-reinforced rubber under vibration : Experiments - Modelling - Finite Element Implementation / Daniel Wollscheid. Universität der Bundeswehr München, Fakultät für Luft- und Raumfahrttechnik. Gutachter: Alexander Lion ; Leif Kari. Betreuer: Alexander Lion." Neubiberg : Universitätsbibliothek der Universität der Bundeswehr München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:706-4247.

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36

Shahtahmasebi, Said. "Statistical modelling of dependency in old age." Thesis, Bangor University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318077.

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37

Fernández, S. Alejandro D. "Modelling the temperature dependences of Silicon Carbide BJTs." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-202754.

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Silicon Carbide (SiC), owing to its large bandgap, has proved itself to be a very viable semiconductor material for the development of extreme temperature electronics. Moreover, its electrical properties like critical field (Ecrit) and saturation velocity (vsat) are superior as compared to the commercially abundant Silicon, thus making it a better alternative for RF and high power applications. The in-house SiC BJT process at KTH has matured a lot over the years and recently developed devices and circuits have shown to work at temperatures exceeding 500˚C. However, the functional reliability o
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38

Ayis, Salma Ahmed. "Modelling unobserved heterogeneity : theoretical and practical aspects." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261592.

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39

Dakpo, K. Hervé. "Non-parametric modelling of pollution-generating technologies : theoretical and methodological considerations, with an application to the case of greenhouse gas emissions in suckler breeding systems in French grassland areas." Thesis, Clermont-Ferrand 1, 2015. http://www.theses.fr/2015CLF10474/document.

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La prise en compte des problèmes environnementaux dans la responsabilité sociale des entreprises a généré en économie de nombreuses propositions. Parmi elles, le cadre d’analyse basé sur l’évaluation de la performance en utilisant notamment les techniques d’enveloppement des données (DEA) s’est très vite répandu dans la littérature théorique comme empirique. Ce travail de thèse s’inscrit dans cette logique en mettant l’accent sur la modélisation des technologies polluantes. Par ailleurs, la question des changements climatiques et de la forte contribution de l’agriculture et en particulier de l
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40

Ho, Duc Thang. "Context dependent fuzzy modelling and its applications." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13574/.

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Fuzzy rule-based systems (FRBS) use the principle of fuzzy sets and fuzzy logic to describe vague and imprecise statements and provide a facility to express the behaviours of the system with a human-understandable language. Fuzzy information, once defined by a fuzzy system, is fixed regardless of the circumstances and therefore makes it very difficult to capture the effect of context on the meaning of the fuzzy terms. While efforts have been made to integrate contextual information into the representation of fuzzy sets, it remains the case that often the context model is very restrictive and/o
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41

Lumley, Thomas. "Marginal regression modelling of weakly dependent data /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/9555.

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42

Song, Fei. "Modelling time-dependent plastic behaviour of geomaterials." Doctoral thesis, Universitat Politècnica de Catalunya, 2021. http://hdl.handle.net/10803/672273.

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Representing the time-dependent plastic behaviour of geomaterials is a critical issue in the correct application of tunnelling design techniques such as the convergence-confinement method or numerical modelling. Furthermore, during underground excavations below the water table, the effect of seepage flow cannot be ignored, and the behaviour of the tunnel must be analysed in a coupled hydro-mechanical framework. The main objective of this thesis is to analyse the response of tunnels excavated in saturated time-dependent plastic rock masses. For this purpose, a time-dependent plastic constituti
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43

Ridley, L. M. "Dependency modelling using fault-tree and cause-consequence analysis." Thesis, Loughborough University, 2000. https://dspace.lboro.ac.uk/2134/7350.

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The technique of fault tree analysis is commonly used to assess the probability of failure of industrial systems. During the analysis of the fault tree the component failures are assumed to occur independently. When this condition is not satisfied alternative approaches such as the Markov method can be used. Constructing the Markov representation of a system is not such as intuitive process for engineers as fault tree construction since the state-transition diagram does not readily document the failure logic. In addition to this the size of the Markov diagram increases rapidly as the number of
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44

Kaehkoenen, Kalle Esa Eelis. "Modelling activity dependencies for building construction project scheduling." Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336061.

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45

Jämsä, Anne. "In vitro modelling of tau phosphorylating kinases: emphasis on Cdk5 /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-400-6/.

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46

Doherty, B. "Context dependency and sub-band based modelling for speech recognition." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368773.

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47

Dimitrova, Dimitrina S. "Dependent risk modelling in (re)insurance and ruin." Thesis, City, University of London, 2007. http://openaccess.city.ac.uk/18910/.

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The work presented in this dissertation is motivated by the observation that the classical (re)insurance risk modelling assumptions of independent and identically distributed claim amounts, Poisson claim arrivals and premium income accumulating linearly at a certain rate, starting from possibly non-zero initial capital, are often not realistic and violated in practice. There is an abundance of examples in which dependence is observed at various levels of the underlying risk model. Developing risk models which are more general than the classical one and can successfully incorporate dependence b
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48

Panchenko, Valentyn. "Nonparametric methods in economics and finance: dependence, causality and prediction." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/30844.

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49

Ranciati, Saverio <1988&gt. "Statistical modelling of spatio-temporal dependencies in NGS data." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7680/.

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Next-generation sequencing (NGS) has rapidly become the current standard in genetic related analysis. This switch from microarray to NGS required new statistical strategies to address the research questions inherent to the considered phenomena. First and foremost, NGS dataset usually consist of discrete observations characterized by overdispersion - that is, discrepancy between expected and observed variability - and an abundance of zeros, measured across a huge number of regions of the genome. With respect to chromatin immunoprecipitation sequencing (ChIP-Seq), a class of NGS data, it is of p
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50

Zurauskiene, Justina. "Bayesian nonparametric approaches to modelling dependencies in systems biology." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/30660.

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All living organisms exhibit complex behaviour, and this is a result of the underlying regulatory mechanisms that occur at cellular and molecular levels. For this reason such reactions are of central importance in the field of systems biology. Throughout this thesis we are concerned with mathematical models that allow us to better under- stand and represent the biological phenomena behind experimental data, and equally to make predictions about key regulatory processes happening in the cells. Specifically, this work explores and demonstrates how modern Bayesian nonparametric techniques, namely
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