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Autore: Grafiati
Pubblicato: 12 aprile 2025

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1

Stamate, Mirela Cristina, Nicolae Todor e Marcel Cosgarea. "Comparative multivariate analyses of transient otoacoustic emissions and distorsion products in normal and impaired hearing". Medicine and Pharmacy Reports 88, n. 4 (6 novembre 2015): 500–512. http://dx.doi.org/10.15386/cjmed-467.

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ABSTRACT:Background & aim: The clinical utility of otoacoustic emissions as a noninvasive objective test of cochlear function has been long studied. Both transient otoacoustic emissions and distorsion products can be used to identify hearing loss, but the extent that they can be used as predictors for hearing loss is still debated. Most studies agree that multivariate analyses have better test performances than univariate analyses. The study aims to determine transient otoacoustic emissions and distorsion products performance in identifying normal and impaired hearing loss, using the pure tone audiogram as a gold standard procedure and different multivariate statistical approaches.Patients and methods: The study included 105 adult subjects with normal hearing and hearing loss that underwent the same test battery: pure-tone audiometry, tympanometry, otoacoustic emission tests. We chose to use the logistic regression as a multivariate statistical technique. Three logistic regression models were developped to characterize the relations between different risk factors (age, sex, tinnitus, demographic features, cochlear status defined by otoacoustic emissions) and hearing status defined by pure-tone audiometry. The multivariate analyses allow the calculation of the logistic score, which is a combination of the inputs, weighted by coefficients, calculated within the analyses. The accuracy of the each model was assessed using receiver operating characteristics curve analysis. We used the logistic score to generate receivers operating curves curves and to estimate the areas under the curves in order to compare different multivariate analyses.Results: Each of the three multivariate analyses provides high values of the area under the curves. Each otoacoustic emission test presents small differences for the value of the area under the curve, but transient otoacoustic emissions seems to be the most powerful predictive for the hearing level for the right ear and distorsion products for the left ear. Adding demographic variables, the value of the area under the curve is similar for both ears, but we found out that tinnitus is a strong predictive variable only for the left ear. Our multivariate analyses revealed that age is a predictor factor of the auditory status for both ears. In our study, gender had no predictive value for hearing level in any of the multivariate analyses. Our study also confirms that the combination of age and distorsion products can better predict hearing level than distorsion products alone. We have found out that the otoacoustic emissions tests have improved performance for both ears when using the multivariate analysis which combines transient otoacoustic emissions and distortion products data.Conclusion: Like any other audiological test, using otoacoustic emissions to identify hearing loss is not without error. Even when applying multivariate analysis, perfect test performance is never achieved. Although most studies demonstrated the benefit of using the multivariate analysis, it has not been incorporated into clinical decisions maybe because of the idiosyncratic nature of multivariate solutions or because of the lack of the validation studies.Key words: otoacoustic emissions, multivariate analyses, logistic regression, hearing loss, receiver operating curves.
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Kleinjung, Tobias. "Zusammenhang zwischen Tinnituston und Frequenzbereich des Gehörverlusts". Laryngo-Rhino-Otologie 97, n. 04 (aprile 2018): 230–31. http://dx.doi.org/10.1055/s-0044-100277.

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Keppler H et al. The relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. J Laryngol Otol 2017; 131: 1017–1025 Ein chronischer Tinnitus ist mit einem reduzierten akustischen Reiz assoziiert. Auf die Schädigung reagiert das zentrale Hörsystem mit Veränderungen. Den Zusammenhang zwischen Tinnituston und Parametern der Audiometrie sowie der distorsiv produzierten otoakustischen Emissionen (DPOAE) untersuchten Ärzte des Hör-Sprachzentrums der Universität der belgischen Stadt Gent.
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Biro, K., L. Noszek, P. Prekopp, K. Vehovszky, E. Nemeth, K. Nagyivanyi, L. Geczi, I. Gaudi e I. Bodrogi. "Spontaneous otoacoustic emissions (SOAE) changes in testicular cancer patients treated with cisplatin: A pilot study of whether the acute ototoxic effect of cisplatin treatment can be detected". Journal of Clinical Oncology 25, n. 18_suppl (20 giugno 2007): 15581. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.15581.

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15581 Background: We studied the acute ototoxic effect of cisplatin in testicular cancer patients with two highly sensitive new methods for detecting high frequency hearing loss: distorsion product otoacoustic emissions (DPOAE), and spontaneous otoacoustic emissions (SOAE). Methods: Checking the acute effect, 32 (63 ears) testicular cancer patients (median age: 33 years, range: 16–59 years) were measured on the first day of their first cycle and after one week of their last cycle of cisplatin treatment. 20 mg/m2 cisplatin was administered for five days, in BEP chemotherapy regimen. The patients got on the average 2.19 cycles (2–3 cycles). We also measured the SOAE of ten healthy control persons (without chemotherapy) matching sex and age distribution of this group. A detailed medical history evaluated audiological risk factors and hearing problems. Tympanometry, DPOAE and SOAE were measured, to detect the acute changes in the inner ear after low cumulative dose of cisplatin treatment. Paired t-test, and sign test was used for statistical analysis. Results: The DPOAE did not show any changes close after cisplatin treatment (average: 2.19 cycles, 2–3 cycles), similarly to our earlier results with pure tone audiometry (PTA) and transiently evoked otoacoustic emission (TOAE). But the SOAE showed significant, early changes in incidence, shape and amplitude, in the treated group. 66% of the SOAE changed after treatment (p=0,006). In the control group (20 ears) the SOAE never changed in a three months period. (It behaves as a fingerprint) Conclusions: DPOAE did not change significantly after 2 or 3 cycles of cisplatin treatment, similarly to our earlier results with PTA, and TOAE, but the change of the SOAE-incidence, shape and amplitude close after cisplatin treatment shows acute changes in the inner ear function (first described in the literature) after administration of low cumulative dose of cisplatin. This case is the first indication of the possible clinical relevance of SOAE. Our observation has to be confirmed in further studies, with larger number of patients. No significant financial relationships to disclose.
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Negley, Candice, Bharti Katbamna, Teresa Crumpton e Gary D. Lawson. "Effects of Cigarette Smoking on Distortion Product Otoacoustic Emissions". Journal of the American Academy of Audiology 18, n. 08 (settembre 2007): 665–74. http://dx.doi.org/10.3766/jaaa.18.8.4.

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This study measured distortion product otoacoustic emissions (DPOAEs) and DPOAE input/output (I/O) curves to assess the effects of smoking on cochlear function. Twenty-four healthy adults, 12 smokers and 12 nonsmokers in the 20–30 years age range were selected based on self-reported histories of five to eight years of smoking or no smoking, respectively. All subjects received tympanometric screening to rule out middle ear pathology. Conventional (0.25–8 kHz) and ultra high frequency (UHF; 10–20 kHz) audiometry showed normal or age-appropriate thresholds across both groups. DPOAE results showed small, but significant, decline in DPOAE levels without concomitant changes in noise floors in smokers as compared to nonsmokers. I/O detection thresholds were also significantly elevated at high frequencies in smokers as compared to their nonsmoking counterparts. These findings indicate that smokers are at greater risk for cochlear damage than nonsmokers, and that DPOAE amplitudes and I/O detection thresholds may identify early changes in cochlear function in smokers. Este estudio midió las emisiones otoacústicas por productos de distorsión (DPOAES) y las curvas de ingreso/salida (I/O) de las DPOAE para evaluar los efectos del fumado sobre la función coclear. Veinticuatro adultos, 12 fumadores y 12 no fumadores, en el rango de edad de 20 a 30 años, fueron seleccionados con base en sus historia auto-reportadas de fumado o no fumado en los últimos 5–8 años, respectivamente. Todos los sujetos se sometieron a un tamizaje timpanométrico para descartar patología del oído medio. La audiometría convencional (0.25–8 kHz) y la de ultra-alta frecuencia (UHF, 10–20 kHz) mostraron umbrales normales o apropiados para la edad en ambos grupos. Los resultados de las DPOAE mostraron una caída pequeña pero significativa en los niveles de las DPOAE en los fumadores comparado con los no fumadores, sin cambios concomitantes en el piso de ruido. Los umbrales I/O de detección también estuvieron significativamente elevados en las altas frecuencias en los fumadores, comparado con sus contrapartes no fumadores. Estos hallazgos indican que los fumadores tienen un mayor riesgo de daño coclear que los no fumadores, y que las amplitudes de las DPOAE y los umbrales I/O de detección pueden identificar cambios tempranos en la función coclear de los fumadores.
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Biro, K., L. Noszek, P. Prekopp, K. Nagyiványi, L. Géczi, I. Gaudi e I. Bodrogi. "Characteristics and Risk Factors of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients Detected by Distorsion Product Otoacoustic Emission". Oncology 70, n. 3 (2006): 177–84. http://dx.doi.org/10.1159/000093776.

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Beattie, Randall C. "Distortion Product Otoacoustic Emissions: Comparison of Sequential versus Simultaneous Presentation of Primary-Tone Pairs". Journal of the American Academy of Audiology 14, n. 09 (ottobre 2003): 471–84. http://dx.doi.org/10.1055/s-0040-1715939.

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Abstract (sommario):
This Grason-Stadler GSI-60 system for measuring distortion product otoacoustic emissions (DPOAEs) allows the examiner to present one set of primary-tone pairs at a time (i.e., sequential presentation), or to present as many as four sets of primary-tone pairs at a time (i.e., simultaneous presentation). The Sequential and Simultaneous protocols were used to compare administration times, DPOAEs, and noise floors (NFs) on normal-hearing subjects at three frequencies (f2 = 1000, 2000, and 4000 Hz) and eight intensities (L1 = 40–75 dB SPL in 5 dB steps; L2 = 30–65 dB SPL). The Simultaneous protocol was completed in less than half the time (mean = 2 minutes, 21 seconds) required for the Sequential protocol (mean = 5 minutes, 13 seconds). When stimulus intensity (L1) was <60 dB SPL, the Sequential and Simultaneous protocols yielded similar DPOAEs and NFs. However, at the higher L1 intensities, the NFs for the Simultaneous protocol were larger than those for the Sequential protocol. The higher Simultaneous NFs reflect the greater system distortion/noise generated by the GSI-60 instrumentation. Reliability was assessed using the standard error of measurement of the difference between two scores. The data revealed no significant differences between protocols, and suggest that differences between two DPOAEs are statistically significant if they exceed ~7 dB (95% confidence interval). Este sistema Grason-Stadler (GSI-60) para la medición de emisiones otoacústicas por productos de distorsión (DPOAE) permite al examinador la presentación de un juego de pares de tonos primarios al mismo tiempo (p.e., presentación secuencial), o presentar hasta cuatro juegos de pares de tonos primarios a la vez (p.e., presentación simultánea). Se utilizaron los protocolos Secuencial y Simultáneo para comparar los tiempos de administración, las DPOAE y los pisos de ruido (NF) en sujetos normo-oyentes, en tres frecuencias (f2 = 1000, 2000 y 4000 Hz) y ocho intensidades (L1 = 40-75 dB en pasos de 5 dB; L2 = 30-65 dB SPL). El protocolo Simultáneo se completó en menos de la mitad del tiempo (media = 2 minutos, 21 segundos) requerido por el protocolo Secuencial (media = 5 minutos, 13 segundos). Cuando la intensidad del estímulo (L1) fue £60 dB SPL, los protocolos Secuencial y Simultáneo rindieron DPOAE y NF similares. Sin embargo, en las intensidades L1 más altas, los NF para el protocolo Simultáneo fueron mayores que aquellas para el protocolo Secuencial. Los NF Simultáneos más altos reflejan la mayor distorsión/ruido del sistema, generado por la instrumentación del GSI-60. La confiabilidad fue evaluada utilizando el error estándar de medición de la diferencia entre los dos puntajes. Los datos revelaron que no había diferencias significativas entre los protocolos, y sugieren que las diferencias entre dos DPOAE son estadísticamente significativas si exceden ~7 dB (intervalo de confianza del 95%).
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Torre, Peter, Laura E. Dreisbach, Richard Kopke, Ron Jackson e Ben Balough. "Risk Factors for Distortion Product Otoacoustic Emissions in Young Men with Normal Hearing". Journal of the American Academy of Audiology 18, n. 09 (ottobre 2007): 749–59. http://dx.doi.org/10.3766/jaaa.18.9.4.

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The purpose of this study was to evaluate the possible effects of risk factors on distortion product otoacoustic emissions (DPOAEs) in young adult men with normal hearing. Four hundred thirty-six United States Marine recruit men (mean age = 19.2 years ± 1.8 years; age range = 17 - 29 years) participated in this study. Questionnaires were given to each recruit to obtain demographic data and history of noise exposure, solvent exposure, smoking history, and hearing-related histories. Otoscopy, tympanometry, pure-tone air-conduction audiometry (2.0 – 8.0 kHz) and DPOAEs (2.3 - 8.0 kHz) were measured. DPOAE levels were lower in Not Hispanic or Latino recruits, in heavy smokers, in recruits who reported loud live music exposure and ringing in their ears after noise exposure. These differences were not statistically significant at all frequencies. Recruits with multiple risk factors had the lowest DPOAEs as compared to recruits with fewer, or no, risk factors; these differences were not statistically significant. Obtaining risk factor data as part of an audiometric evaluation is important even though the individual may have normal hearing. El propósito de este estudio fue evaluar los posibles efectos de los factores de riesgo sobre las emisiones otoacústicas por productos de distorsión (DPOAE) en hombres adultos jóvenes con audición normal. Cuatrocientos cuarenta y seis reclutas masculinos de la Marina de los Estados Unidos (edad media de 19.2 años ± 1.8; rango de edad = 17 - 29 años) participaron del estudio. Los cuestionarios se entregaron a cada recluta para obtener datos demográficos e historias de exposición a ruido, exposición a solventes, historia de fumado, e historias relacionadas con la audición. Se realizaron otoscopias, timpanometrías, audiometrías de tonos puros por vía aérea (2.0 – 8.0 kHz) y DPOAE (2.3 – 8.0 kHz). Los niveles de las DPOAE fueron más bajos en reclutas no hispánicos o no latinos, en fumadores fuertes, en reclutas que reportaron exposición a música fuerte en vivo, y ruidos en los oídos después de exposición a ruido. Estas diferencias no fueron estadísticamente significativas en todas las frecuencias. Los reclutas con múltiples factores de riesgo tuvieron las DPOAEs más bajas, comparados con los reclutas con menos o ningún dato de factores de riesgo; estas diferencias no fueron estadísticamente significativas. Obtener datos de factores de riesgo como parte de una evaluación audiométrica es importante aunque los individuos tengan audición normal.
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Kossowski, Michel, Thierry Mom, Matthieu Guitton, Jean-Luc Poncet, Pierre Bonfils e Paul Avan. "Fine Alterations of Distortion-product Otoacoustic Emissions after Moderate Acoustic Overexposure in Guinea Pigs: Alteraciones moderadas de los productos de distorsion de las emisiones otoacusticas después de sobrexposición acústica moderada en cobayos". International Journal of Audiology 40, n. 3 (gennaio 2001): 113–22. http://dx.doi.org/10.3109/00206090109073106.

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Beattie, Randall C., O. T. Kenworthy e Christina A. Luna. "Immediate and short-term reliability of distortion-product otoacoustic emissions: Confiabilidad inmediata y a corto plazo de las emisiones otoacústicas por productos de distorsión". International Journal of Audiology 42, n. 6 (gennaio 2003): 348–54. http://dx.doi.org/10.3109/14992020309101328.

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O'rourke, Clare, Carlie Driscoll, Joseph Kei e Veronica Smyth. "A normative study of distortion-product otoacoustic emissions in 6-year-old schoolchildren: Estudio normativo de las emisiones otoacústicas por productos de distorsión en escolares de 6 años". International Journal of Audiology 41, n. 3 (gennaio 2002): 162–69. http://dx.doi.org/10.3109/14992020209077180.

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ERSOY ÇALLIOĞLU, Elif, Ebru SALMAN, Öznur DOĞAN e Ali Sami BERÇİN. "Effects of Esmolol Induced Hypotensive Anaesthesia on Distortion Product Otoacoustic Emission". Kulak Burun Boğaz ve Baş Boyun Cerrahisi Dergisi 28, n. 1 (2020): 49–56. http://dx.doi.org/10.24179/kbbbbc.2020-73483.

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Rasmussen, Arne Nørby, Poul Aabo Osterhammel, Søren Peter Lund, Gitte Bondegård Kristiansen e Svend Andersen. "A system for measuring distortion product otoacoustic emissions at ultra-sonic frequencies in rodents Un sistema para medida emisiones otoacústicas por productos de distorsión en roedores a frecuencias ultra-sónicas". International Journal of Audiology 44, n. 4 (aprile 2005): 237–43. http://dx.doi.org/10.1080/14992020500057640.

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SEIDMAN, M. "Distortion-product Otoacoustic Emissions". Otolaryngology - Head and Neck Surgery 112, n. 4 (aprile 1995): 628. http://dx.doi.org/10.1016/s0194-5998(95)70227-x.

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Seidman, Michael D. "Distortion-Product Otoacoustic Emissions". Otolaryngology–Head and Neck Surgery 112, n. 4 (aprile 1995): 628. http://dx.doi.org/10.1177/019459989511200425.

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Silman, Shlomo, Michele B. Emmer e Carol A. Silverman. "Technical Report: Distortion Product Otoacoustic Emissions That Are Not Outer Hair Cell Emissions". Journal of the American Academy of Audiology 20, n. 05 (maggio 2009): 306–10. http://dx.doi.org/10.3766/jaaa.20.5.3.

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Abstract (sommario):
Purpose: To present a case study in order to alert clinicians to the possibility of occurrence of intermodulation distortion during otoacoustic emissions testing that arises from the cavity formed by the external auditory meatus and tympanic membrane rather than from the inner ear, compromising the reliability and validity of otoacoustic emissions testing. Research Design: Prospective case study. Study Sample: A young (26-year-old) female adult with a longstanding, bilateral, essentially moderate to severe sensorineural hearing loss presented with robust distortion product otoacoustic emissions. Results: Repeat otoacoustic emissions testing with another device of the same model revealed essentially absent distortion product otoacoustic emissions and transient otoacoustic emissions. Calibration of both otoacoustic emissions devices using a 1 cc membranous cavity indicated present intermodulation distortion for the device that yielded robust distortion product otoacoustic emissions for the patient but absent intermodulation distortion for the device that revealed absent distortion product otoacoustic emissions and absent transient evoked otoacoustic emissions for the patient. The calibration findings for the device yielding intermodulation distortion in the cavity were confirmed by an engineer of a technical instrumentation company. The device was shipped back to the manufacturer of the device for repair. The manufacturer's engineers diagnosed the problem as an interruption in the relay system. Following repair, calibration revealed the absence of intermodulation distortion in the 1 cc membranous cavity. Conclusions: The findings have implications for the reliability and validity of otoacoustic emissions. Clinicians should routinely calibrate otoacoustic emissions devices using 1.0 and 0.5 cc membranous cavities to rule out intermodulation distortion that could produce artifactual otoacoustic emissions in patients.
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Lasky, Robert, Jeffrey Perlman e Kurt Hecox. "Distortion-Product Otoacoustic Emissions in". Ear and Hearing 13, n. 6 (dicembre 1992): 430–41. http://dx.doi.org/10.1097/00003446-199212000-00009.

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Silva, Paula Botelho da, Ana Cláudia Fiorini e Marisa Frasson de Azevedo. "Otoacoustic emissions in young adults exposed to drums noise of a college band". Revista CEFAC 19, n. 5 (settembre 2017): 645–53. http://dx.doi.org/10.1590/1982-0216201719512216.

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ABSTRACT Purpose: to identify cochlear dysfunction and occurrence of tinnitus in young adults exposed to drums noise of a college band. Methods: the sample included 50 subjects: 25 musicians (study group) and 25 non-musicians (control group). The procedures included anamnesis, pure tone audiometry, acoustic impedance and Transient Evoked Otoacoustic Emissions, Distortion Product Otoacoustic Emissions and Distortion Product Otoacoustic Emissions Input-Output function. Results: positive correlation between the occurrence of tinnitus and the variables exposure time and use of personal stereos was found. Overall, the study group showed significantly lower Transient Evoked Otoacoustic Emissions, when compared to the control group. In the study group, there was a tendency toward worse response in 6 kHz(f2) in Distortion Product Otoacoustic Emissions in both ears. The Distortion Product Otoacoustic Emissions Input-Output function did not differ between groups nor did its slope. Conclusion: in general, otoacoustic emissions were worse in noise-exposed young people (study group) when compared to the unexposed (control group), indicating that the test may be important in early identification of cochlear changes.
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Wooles, N., M. Mulheran, P. Bray, M. Brewster e A. R. Banerjee. "Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure". Journal of Laryngology & Otology 129, n. 12 (9 novembre 2015): 1174–81. http://dx.doi.org/10.1017/s0022215115002790.

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AbstractObjective:To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupational noise exposure related auditory deficit.Methods:A retrospective review was conducted of pure tone audiometry and distortion product otoacoustic emission data obtained sequentially during mandatory screening of brickyard workers (n = 16). Individual pure tone audiometry thresholds were compared with distortion product otoacoustic emission amplitudes, and a correlation of these measurements was conducted.Results:Pure tone audiometry threshold elevation was identified in 13 out of 16 workers. When distortion product otoacoustic emission amplitudes were compared with pure tone audiometry thresholds at matched frequencies, no evidence of a robust relationship was apparent. Seven out of 16 workers had substantial distortion product otoacoustic emissions with elevated pure tone audiometry thresholds.Conclusion:No clinically relevant predictive relationship between distortion product otoacoustic emission amplitude and pure tone audiometry threshold was apparent. These results do not support the replacement of pure tone audiometry with distortion product otoacoustic emissions in screening. Distortion product otoacoustic emissions at frequencies associated with elevated pure tone audiometry thresholds are evidence of intact outer hair cell function, suggesting that sites distinct from these contribute to auditory deficit following ototrauma.
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Timpe-Syverson, Genaya Kae, e T. Newell Decker. "Attention Effects on Distortion-Product Otoacoustic Emissions with Contralateral Speech Stimuli". Journal of the American Academy of Audiology 10, n. 07 (luglio 1999): 371–78. http://dx.doi.org/10.1055/s-0042-1748509.

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AbstractThis study investigated the effect of selective attention on the distortion-product otoacoustic emission (DPOAE) level through the use of environmentally meaningful, contralateral auditory stimuli. Four different conditions were used for measurement: quiet, contralateral noise, contralateral speech (unattended), and contralateral speech (attended). A statistically significant suppression effect for both the noise and speech conditions was found. However, there was no support for an auditory selective attention effect on the distortion-product amplitude. Abbreviations: ABR = auditory brainstem response, ANOVA = analysis of variance, DPOAEs = distortion-product otoacoustic emissions, IHC = inner hair cell, MES = medial efferent system, OAEs = otoacoustic emissions, OCB = olivochlear bundle, OHC = outer hair cell, SOAEs = spontaneous otoacoustic emissions, TEOAEs = transient evoked otoacoustic emissions
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Yellin, M. Wende, e Robert D. Stillman. "Otoacoustic Emissions in Normal-Cycling Females". Journal of the American Academy of Audiology 10, n. 07 (luglio 1999): 400–408. http://dx.doi.org/10.1055/s-0042-1748512.

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AbstractThe purpose of this study was to determine if the menstrual cycle influences the amplitude of transient (TEOAEs) and distortion-product (DPOAEs) otoacoustic emissions. Thirteen normal-hearing, normal-cycling females were monitored weekly for 12 weeks. TEOAE and DPOAE amplitudes were analyzed to determine if amplitude changes could be detected and correlated to phases of the menstrual cycle. No systematic amplitude changes were observed, demonstrating that evoked OAEs are unaffected by physiologic changes associated with the menstrual cycle. Abbreviations: ABR = auditory brainstem response, DPOAEs = distortion product otoacoustic emissions, OAEs = otoacoustic emissions, RMANOVA = repeated measures analysis of variance, SOAEs = spontaneous otoacoustic emissions, TEOAEs = transient evoked otoacoustic emissions
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Kirubaharane, S. I., S. Palani, A. Alexander e A. Sreenivasan. "Effect of chronic suppurative otitis media on distortion product otoacoustic emission input–output functions in conventional and ultra-high frequencies". Journal of Laryngology & Otology 133, n. 11 (21 ottobre 2019): 995–1004. http://dx.doi.org/10.1017/s0022215119002123.

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AbstractBackgroundDetection and valid measurements of distortion product otoacoustic emissions are not influenced by cochlear status alone, but also by middle-ear status. There is a need to understand the use of ultra-high frequency distortion product otoacoustic emissions in cases of abnormal distortion product otoacoustic emission findings for conventional frequencies related to the middle-ear condition.MethodThe present study investigated distortion product otoacoustic emission input–output functions in conventional and ultra-high frequencies in: 37 adults with chronic suppurative otitis media (clinical group) and 37 adults with normal hearing sensitivity (control group).ResultsThere were significant reductions in distortion product otoacoustic emission amplitude and mean signal-to-noise ratio in the clinical group compared to the control group, especially for conventional frequencies.ConclusionThere was a significant reduction in the rate of ears with measurable distortion product otoacoustic emissions in the clinical group, especially for conventional frequencies. The effect of chronic suppurative otitis media was more pronounced in the conventional frequency range compared to the smaller effect seen in the ultra-high frequency range.
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Wing-Kin Ma e Yuan-Ting Zhang. "Estimation of distortion product otoacoustic emissions". IEEE Transactions on Biomedical Engineering 46, n. 10 (1999): 1261–64. http://dx.doi.org/10.1109/10.790504.

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Widick, Michael P., Fred F. Telischi, Brenda L. Lonsbury-Martin e Barden B. Stagner. "First Place — Resident Clinical Science Award 1994: Early Effects of Cerebellopontine Angle Compression on Rabbit Distortion-Product Otoacoustic Emissions: A Model for Monitoring Cochlear Function during Acoustic Neuroma Surgery". Otolaryngology–Head and Neck Surgery 111, n. 4 (ottobre 1994): 407–16. http://dx.doi.org/10.1177/019459989411100404.

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A rabbit model was developed to simulate the effects of Ischemia that may occur during surgical removal of tumors Involving the cerebellopontine angle or internal auditory canal. Specifically, the internal auditory artery was visualized through a posterior craniotomy and mechanically compressed for repetitive 1-minute intervals with a micromanipulator-controlled glass pipet terminating in a smooth bead. The 2f1-f2 distortion-product otoacoustic emissions were used to monitor the susceptibility of cochlear function to compressive effects. Distortion-product otoacoustic emissions were measured during discrete preblock, block, and postblock periods to determine the time course of distortion-product otoacoustic emission reduction and its return to baseline levels after rapid obstruction and resumption, respectively, of the cochlear vascular supply. Comparisons during these times indicated that preblock distortion-product otoacoustic emission levels were very stable, often varying by less than 1 dB. Additionally, distortion-product otoacoustic emissions were very sensitive to brief vascular occlusions in that, within approximately 25 seconds of blockage onset, emission levels at all frequencies decreased at rates of about − 1.5 dB/second. On alleviation of the occlusion, distortion-product otoacoustic emissions rapidly and completely returned to preblock levels with a delay of about 4 seconds and recovery slopes of about 10.5 dB/second. A notable finding in some animals was that early and reproducible variations in distortion-product otoacoustic emission levels occurred within 5 to 8 seconds of internal auditory artery compression. When present, these transitory changes on distortion-product otoacoustic emission levels acted as early warning signs for vascular compromise of cochlear function.
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24

Keppler, H., S. Degeest e I. Dhooge. "The relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions". Journal of Laryngology & Otology 131, n. 11 (6 settembre 2017): 1017–25. http://dx.doi.org/10.1017/s0022215117001803.

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AbstractObjectives:Chronic tinnitus is associated with reduced auditory input, which results in changes in the central auditory system. This study aimed to examine the relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. For audiometry, the parameters represented the edge frequency of hearing loss, the frequency of maximum hearing loss and the frequency range of hearing loss. For distortion product otoacoustic emissions, the parameters were the frequency of lowest distortion product otoacoustic emission amplitudes and the frequency range of reduced distortion product otoacoustic emissions.Method:Sixty-seven patients (45 males, 22 females) with subjective chronic tinnitus, aged 18 to 73 years, were included.Results:No correlation was found between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. However, tinnitus pitch fell mostly within the frequency range of hearing loss.Conclusion:The current study seems to confirm the relationship between tinnitus pitch and the frequency range of hearing loss, thus supporting the homeostatic plasticity model.
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Kuroda, Tsutomu, Satoshi Fukuda, Eiji Chida, Masaaki Kashiwamura, Michiya Matsumura, Ryuichirou Ohwatari e Yukio Inuyama. "Effects of spontaneous otoacoustic emissions on distortion product otoacoustic emission". Auris Nasus Larynx 28 (maggio 2001): S33—S38. http://dx.doi.org/10.1016/s0385-8146(01)00074-8.

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26

Migirov, L., e M. Wolf. "Distortion product otoacoustic emissions following stapedectomy versus stapedotomy". Journal of Laryngology & Otology 124, n. 1 (14 ottobre 2009): 16–18. http://dx.doi.org/10.1017/s0022215109991150.

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AbstractObjectives:To evaluate distortion product otoacoustic emissions following stapes surgery in patients with otosclerosis, and to compare in this respect two surgical techniques used in our department.Method:This retrospective study included 17 stapedectomy and 23 stapedotomy patients aged 16–68 years who had been followed up for at least 12 months. Distortion product otoacoustic emission results at 2, 3, 4 and 5 kHz (i.e. =f2, with 2f1 − f2 = 0.6f2) were obtained pre-operatively and four weeks post-operatively. The control group included 13 volunteers aged 18–50 years with normal hearing and normal otoscopic findings.Results:Distortion product otoacoustic emissions were detected pre-operatively in 34.8 per cent of stapedotomy patients and 29.4 per cent of stapedectomy patients, and post-operatively in 91.3 per cent of stapedotomy patients and 88.2 per cent of stapedectomy patients. The differences between the stapedotomy and stapedectomy groups were statistically insignificant for each tested frequency, both pre- and post-operatively. The patients' post-operative distortion product otoacoustic emission amplitudes were less than those of normal hearing individuals, even in patients with complete air–bone gap closure and a significant improvement in hearing.Conclusion:Distortion product otoacoustic emissions were detected in most of our patients following successful stapes surgery, and appeared to be unaffected by the surgical technique or prosthesis used.
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Kim, D.-K., S.-N. Park, K.-H. Park, H. G. Choi, E.-J. Jeon, Y.-S. Park e S. W. Yeo. "Clinical characteristics and audiological significance of spontaneous otoacoustic emissions in tinnitus patients with normal hearing". Journal of Laryngology & Otology 125, n. 3 (5 novembre 2010): 246–50. http://dx.doi.org/10.1017/s0022215110002380.

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AbstractObjective:To define the clinical and audiological features of normal-hearing tinnitus patients with spontaneous otoacoustic emissions, and to evaluate the role of spontaneous otoacoustic emissions in tinnitus generation.Materials and methods:Thirty-two patients with spontaneous otoacoustic emissions were compared with 29 patients without spontaneous otoacoustic emissions, regarding clinical and audiological aspects.Results:The mean age of the study group subjects was significantly lower, and they experienced the kindling effect less frequently than the control group. The mean tinnitus handicap inventory score of the study group was considerably higher than that of the controls, although the difference was not statistically significant. The study group had significantly quieter tinnitus, and higher transient evoked and distortion product otoacoustic emission responses, compared with the control group.Conclusions:Normal-hearing tinnitus patients with spontaneous otoacoustic emissions have different clinical and audiological characteristics, compared with those without spontaneous otoacoustic emissions. Appropriate evaluation and treatment should be considered at an early stage in these patients.
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28

Garbaruk, Ekaterina S., Pavel V. Pavlov, Oksana K. Gorkina, Nina V. Subora e Margarita B. Belogurova. "Otoacoustic emissions: major trends in pediatric practice". Pediatrician (St. Petersburg) 11, n. 3 (19 agosto 2020): 101–8. http://dx.doi.org/10.17816/ped113101-108.

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The high prevalence of hearing loss in children determines the need for reliable methods for the timely detection and diagnosis of hearing impairment at any age, starting from a birth. Otoacoustic emissions are widely used in hearing screening and audiological assessment as an objective tool for cochlear status evaluation. Over the past 30 years, their use in routine audiological assessments has increased significantly. Understanding the subtle processes that occur in the cochlea during the transmission of acoustic stimuli which generate otoacoustic emissions as well as knowledge about the registration parameters, otoacoustic emissions characteristics, otoacoustic emissions advantages and constraints are important for results analysis. Contemporary understanding of the occurrence of auditory sensations as well as the description of various types of otoacoustic emissions used in routine clinical practice (transient otoacoustic emissions and distorting product otoacoustic emissions) are presented in the review. The features of otoacoustic emissions using in pediatric practice are described: in newborns hearing screening, including the peculiarities of applying of this test for infants having had got their treatment in the intensive care units. Otoacoustic emissions significance for hearing diagnosis and as well as for ototoxicity monitoring is shown. Reliability, non-invasiveness, objectivity, simplicity of the otoacoustic emissions testing has done it one of the main methods both in hearing screening and diagnostics for children on any age.
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29

Ozturan, Orhan, e Cagatay Oysu. "Influence of spontaneous otoacoustic emissions on distortion product otoacoustic emission amplitudes". Hearing Research 127, n. 1-2 (gennaio 1999): 129–36. http://dx.doi.org/10.1016/s0378-5955(98)00184-1.

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30

Karabulut, H., M. Dagli, A. Ates e Y. Karaaslan. "Results for audiology and distortion product and transient evoked otoacoustic emissions in patients with systemic lupus erythematosus". Journal of Laryngology & Otology 124, n. 2 (26 ottobre 2009): 137–40. http://dx.doi.org/10.1017/s0022215109991332.

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AbstractThe aim of the current study was to investigate hearing loss and cochlear function in patients with systemic lupus erythematosus, using audiology, distortion product otoacoustic emissions and transient evoked otoacoustic emissions.Study design:Prospective, case–control study.Methods:The study included 26 randomised patients with systemic lupus erythematosus (52 ears) and 30 healthy control subjects (60 ears). Pure tone audiometry was performed at 250 and 500 Hz and at 1, 2, 4, 6, 8, 10, 12, 14 and 16 kHz. Distortion product otoacoustic emissions and transient evoked otoacoustic emissions were measured using Biologic System equipment with Scout Acoustic Emissions System software.Results:The distortion product otoacoustic emission signal responses were significantly different only at 750 Hz, while the distortion product otoacoustic emission signal–noise ratios were significantly different at 750 Hz and 6 kHz (p < 0.05), comparing patients and controls. The transient evoked otoacoustic emission signal–noise ratios were significantly different at 2 and 3 kHz, comparing patients and controls (p < 0.05). The transient evoked otoacoustic emission total signal–noise ratios were significantly different, comparing patients and controls (p < 0.05). In addition, the pure tone audiometry thresholds were significantly different at 250 and 500 Hz and at 1, 2, 10 and 12 kHz, comparing patients and controls (p < 0.05).Conclusion:Our findings do not completely agree with those of previous temporal bone histopathological studies. However, our results do support a general picture of low frequency hearing loss in systemic lupus erythematosus patients. We consider these results to be related to endolymphatic and cochlear hydrops, and we suggest that electrocochleography could be performed in further studies for clarification of this subject.
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31

Vinck, Bart M., Eddy De Vel, Zheng-Min Xu e Paul B. Van Cauwenberge. "Distortion Product Otoacoustic Emissions: A Normative Study". International Journal of Audiology 35, n. 5 (gennaio 1996): 231–45. http://dx.doi.org/10.3109/00206099609071944.

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32

Bowling, Thomas, Kaikai Che, Charlsie Lemons e Julien Meaud. "Computational modeling of distortion product otoacoustic emissions". Journal of the Acoustical Society of America 137, n. 4 (aprile 2015): 2410. http://dx.doi.org/10.1121/1.4920783.

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33

Bershad, Eric M., Mian Z. Urfy, Alina Pechacek, Mary McGrath, Eusebia Calvillo, Nicholas J. Horton e Susan E. Voss. "Intracranial Pressure Modulates Distortion Product Otoacoustic Emissions". Neurosurgery 75, n. 4 (27 maggio 2014): 445–55. http://dx.doi.org/10.1227/neu.0000000000000449.

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Abstract BACKGROUND: There is an important need to develop a noninvasive method for assessing intracranial pressure (ICP). We report a novel approach for monitoring ICP using cochlear-derived distortion product otoacoustic emissions (DPOAEs), which are affected by ICP. OBJECTIVE: We hypothesized that changes in ICP may be reflected by altered DPOAE responses via an associated change in perilymphatic pressure. METHODS: We measured the ICP and DPOAEs (magnitude and phase angle) during opening and closing in 20 patients undergoing lumbar puncture. RESULTS: We collected data on 18 patients and grouped them based on small (&lt;4 mm Hg), medium (5–11 mm Hg), or large (≥15 mm Hg) ICP changes. A permutation test was applied in each group to determine whether changes in DPOAEs differed from zero when ICP changed. We report significant changes in the DPOAE magnitudes and angles, respectively, for the group with the largest ICP changes and no changes for the group with the smallest changes; the group with medium changes had variable DPOAE changes. CONCLUSION: We report, for the first time, systematic changes in DPOAE magnitudes and phase in response to acute ICP changes. Future studies are warranted to further develop this new approach.
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34

Cianfrone, Giancarlo, Giovanni Ralli, Mariantonietta Fabbricatore, Giancarlo Altissimi e Giuseppe Nola. "Distortion product otoacoustic emissions in Ménière's disease". Scandinavian Audiology 29, n. 2 (gennaio 2000): 111–19. http://dx.doi.org/10.1080/010503900424525.

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35

Preyer, Serena, Alexander Baisch, Dominik Bless e Anthony W. Gummer. "Distortion product otoacoustic emissions in human hypercholesterolemia". Hearing Research 152, n. 1-2 (febbraio 2001): 139–51. http://dx.doi.org/10.1016/s0378-5955(00)00245-8.

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36

Strain, G. M., A. J. Rosado Martinez, K. A. McGee e C. L. McMillan. "Distortion product otoacoustic emissions in geriatric dogs". Veterinary Journal 216 (ottobre 2016): 101–6. http://dx.doi.org/10.1016/j.tvjl.2016.07.010.

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37

Kasse, C. A., J. R. G. Testa, Y. Fukuda e O. L. M. Cruz. "Distortion product otoacoustic emissions in Bell's palsy". International Congress Series 1240 (ottobre 2003): 251–55. http://dx.doi.org/10.1016/s0531-5131(03)00756-8.

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38

Lonsbury-Martin, Brenda L., Marcy J. McCoy, Martin L. Whitehead e Glen K. Martin. "Clinical Testing of Distortion-Product Otoacoustic Emissions". Ear and Hearing 14, n. 1 (febbraio 1993): 11–22. http://dx.doi.org/10.1097/00003446-199302000-00003.

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39

Lonsbury-Martin, Brenda L., Martin L. Whitehead e Glen K. Martin. "Clinical Applications of Otoacoustic Emissions". Journal of Speech, Language, and Hearing Research 34, n. 5 (ottobre 1991): 964–81. http://dx.doi.org/10.1044/jshr.3405.964.

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Abstract (sommario):
On the basis of recent advances in auditory physiology, new tests of cochlear function have been developed using measures of otoacoustic emissions. In the present report, the clinical potential for each of the four basic emission types is examined. In addition, the practical advantages of examining the ear with two specific types of evoked emissions, transiently evoked and distortion-product otoacoustic emissions, are reviewed in detail. Finally, the future role of tests of otoacoustic emissions in the diagnosis of hearing impairment is discussed. The current view is that evoked emissions hold promise as an essential part of the clinical examination of the auditory system.
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40

Cevette, Michael J., Danielle Drew, Teresa M. Webb e Mitchell S. Marion. "Cisplatin Ototoxicity, Increased DPOAE Amplitudes, and Magnesium Deficiency". Journal of the American Academy of Audiology 11, n. 06 (giugno 2000): 323–29. http://dx.doi.org/10.1055/s-0042-1748061.

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AbstractOuter hair cell (OHC) metabolism is blocked by cisplatin. Concurrent changes in the renal handling of magnesium occur because of the damage cisplatin causes to the renal proximal tubule cells within the thick ascending loop of Henle. Although there is no evidence of cisplatin within the OHCs, there are significant levels of intracellular calcium, the antagonist to magnesium at the cell membrane. The OHC motile response is dependent on intracellular calcium. When the calcium current is suppressed by an antagonist, the extracellular OHC microphonic potential decreases. Magnesium deficiency is known to produce hyperexcitabililty within the central nervous system, including fatal audiogenic seizures. In addition, increases in the amplitude of the auditory brainstem response wave V occur with aminoglycoside therapy and magnesium deficiency. This paper illustrates the amplitude growth of distortion product otoacoustic emissions in two patients treated with cisplatin and explores the possible underlying reasons why this may be related to magnesium metabolism. Abbreviations: DPOAEs = distortion product otoacoustic emissions, OAEs = otoacoustic emissions, OHC = outer hair cell, TEOAEs = transient otoacoustic emissions
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41

Nakamura, Masaichi, Masashi Sugasawa e Kimitaka Kaga. "Evoked Otoacoustic Emissions(EOAEs) and Distortion Product Otoacoustic Emissions(OPOAEs) in Patients with Idiopathic Sudden Deafness." AUDIOLOGY JAPAN 37, n. 4 (1994): 265–69. http://dx.doi.org/10.4295/audiology.37.265.

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42

Norrix, Linda W., e Theodore J. Glattke. "Distortion product otoacoustic emissions created through the interaction of spontaneous otoacoustic emissions and externally generated tones". Journal of the Acoustical Society of America 100, n. 2 (agosto 1996): 945–55. http://dx.doi.org/10.1121/1.416206.

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43

Sigaleva, Е. E., L. Yu Marchenko, O. B. Pasekova, E. I. Matsnev, K. V. Gordienko e V. I. Grishin. "PROSPECTS FOR USING THE METHOD OF BREATHING NORMOXIC ARGON/OXYGEN GAS MIXTURE FOR PURPOSES OF NOISE OTOPROTECTION". Aerospace and Environmental Medicine 57, n. 2 (2023): 65–73. http://dx.doi.org/10.21687/0233-528x-2023-57-2-65-73.

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Effectiveness of inhaled normoxic argon/oxygen mixture was tested with participation of volunteers with good initial hearing prior to white noise exposure (preconditioning). Results of comprehensive audiometry including measurements of tone threshold, delayed evoked otoacoustic emissions, otoacoustic emissions at distortion-product frequencies and short-latency auditory evoked potentials attested to the benefit of this method of otoprotection.
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44

Avan, Paul, e Pierre Bonfils. "Frequency Specificity of Human Distortion Product Otoacoustic Emissions". International Journal of Audiology 32, n. 1 (gennaio 1993): 12–26. http://dx.doi.org/10.3109/00206099309072924.

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45

Moulin, Annie, Jean-Christophe Bera e Lionel Collet. "Distortion Product Otoacoustic Emissions and Sensorineural Hearing Loss". International Journal of Audiology 33, n. 6 (gennaio 1994): 305–26. http://dx.doi.org/10.3109/00206099409071890.

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46

Balatsouras, DimitriosG, Antonis Tzagaroulakis, Dimitris Kandiloros, Elisabeth Ferekidou, Stavros Korres e GeorgeS Korres. "Distortion product otoacoustic emissions in an industrial setting". Noise and Health 11, n. 43 (2009): 103. http://dx.doi.org/10.4103/1463-1741.50695.

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47

Takahasih, Shin, Kenji Ohyama, Katuhisa Ikeda, Hiroshi Wada e Tomonori Takasaka. "Distortion Product Otoacoustic Emissions in Cisplatin Administered Patients." AUDIOLOGY JAPAN 38, n. 3 (1995): 229–36. http://dx.doi.org/10.4295/audiology.38.229.

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48

Sakashita, Tetsushi, Takeshi Kubo, Makoto Kusuki, Kazushi Kyunai, Keita Ueno, Chie Hikawa e Yoshiaki Nakai. "Distortion-product Otoacoustic Emissions in Idiopathic Sudden Deafness." AUDIOLOGY JAPAN 40, n. 2 (1997): 100–108. http://dx.doi.org/10.4295/audiology.40.100.

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49

Zebian, Makram, Volker Schirkonyer, Johannes Hensel, Sven Vollbort, Thomas Fedtke e Thomas Janssen. "Distortion product otoacoustic emissions upon ear canal pressurization". Journal of the Acoustical Society of America 133, n. 4 (aprile 2013): EL331—EL337. http://dx.doi.org/10.1121/1.4795290.

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50

Wagner, Wolfgang, Guido Heppelmann, Reinhard Vonthein e Hans Peter Zenner. "Test???Retest Repeatability of Distortion Product Otoacoustic Emissions". Ear and Hearing 29, n. 3 (giugno 2008): 378–91. http://dx.doi.org/10.1097/aud.0b013e31816906e7.

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