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Letteratura scientifica selezionata sul tema "DYNAMIC DCVSL"

Autore: Grafiati

Pubblicato: 11 settembre 2023

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Articoli di riviste sul tema "DYNAMIC DCVSL"

Bajpai, Pratibha, Neeta Pandey, Kirti Gupta, Shrey Bagga e Jeebananda Panda. "On Improving the Performance of Dynamic DCVSL Circuits". Journal of Electrical and Computer Engineering 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/8207104.

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This contribution aims at improving the performance of Dynamic Differential Cascode Voltage Switch Logic (Dy-DCVSL) and Enhanced Dynamic Differential Cascode Voltage Switch Logic (EDCVSL) and suggests three architectures for the same. The first architecture uses transmission gates (TG) to reduce the logic tree depth and width, which results in speed improvement. As leakage is a dominant issue in lower technology nodes, the second architecture is proposed by adapting the leakage control technique (LECTOR) in Dy-DCVSL and EDCVSL. The third proposed architecture combines features of both the first and the second architectures. The operation of the proposed architectures has been verified through extensive simulations with different CMOS submicron technology nodes (90 nm, 65 nm, and 45 nm). The delay of the gates based on the first architecture remains almost the same for different functionalities. It is also observed that Dy-DCVSL gates are 1.6 to 1.4 times faster than their conventional counterpart. The gates based on the second architecture show a maximum of 74.3% leakage power reduction. Also, it is observed that the percentage of reduction in leakage power increases with technology scaling. Lastly, the gates based on the third architecture achieve similar leakage power reduction values to the second one but are not able to exhibit the same speed advantage as achieved with the first architecture.

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Wong, Man Yan, Samantha L. Cavolo e Edwin S. Levitan. "Synaptic neuropeptide release by dynamin-dependent partial release from circulating vesicles". Molecular Biology of the Cell 26, n. 13 (luglio 2015): 2466–74. http://dx.doi.org/10.1091/mbc.e15-01-0002.

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Neurons release neuropeptides, enzymes, and neurotrophins by exocytosis of dense-core vesicles (DCVs). Peptide release from individual DCVs has been imaged in vitro with endocrine cells and at the neuron soma, growth cones, neurites, axons, and dendrites but not at nerve terminals, where peptidergic neurotransmission occurs. Single presynaptic DCVs have, however, been tracked in native terminals with simultaneous photobleaching and imaging (SPAIM) to show that DCVs undergo anterograde and retrograde capture as they circulate through en passant boutons. Here dynamin (encoded by the shibire gene) is shown to enhance activity-evoked peptide release at the Drosophila neuromuscular junction. SPAIM demonstrates that activity depletes only a portion of a single presynaptic DCV's content. Activity initiates exocytosis within seconds, but subsequent release occurs slowly. Synaptic neuropeptide release is further sustained by DCVs undergoing multiple rounds of exocytosis. Synaptic neuropeptide release is surprisingly similar regardless of anterograde or retrograde DCV transport into boutons, bouton location, and time of arrival in the terminal. Thus vesicle circulation and bidirectional capture supply synapses with functionally competent DCVs. These results show that activity-evoked synaptic neuropeptide release is independent of a DCV's past traffic and occurs by slow, dynamin-dependent partial emptying of DCVs, suggestive of kiss-and-run exocytosis.

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Trexler, Adam J., Kem A. Sochacki e Justin W. Taraska. "Imaging the recruitment and loss of proteins and lipids at single sites of calcium-triggered exocytosis". Molecular Biology of the Cell 27, n. 15 (agosto 2016): 2423–34. http://dx.doi.org/10.1091/mbc.e16-01-0057.

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How and when the dozens of molecules that control exocytosis assemble in living cells to regulate the fusion of a vesicle with the plasma membrane is unknown. Here we image with two-color total internal reflection fluorescence microscopy the local changes of 27 proteins at single dense-core vesicles undergoing calcium-triggered fusion. We identify two broad dynamic behaviors of exocytic molecules. First, proteins enriched at exocytic sites are associated with DCVs long before exocytosis, and near the time of membrane fusion, they diffuse away. These proteins include Rab3 and Rab27, rabphilin3a, munc18a, tomosyn, and CAPS. Second, we observe a group of classical endocytic proteins and lipids, including dynamins, amphiphysin, syndapin, endophilin, and PIP2, which are rapidly and transiently recruited to the exocytic site near the time of membrane fusion. Dynamin mutants unable to bind amphiphysin were not recruited, indicating that amphiphysin is involved in localizing dynamin to the fusion site. Expression of mutant dynamins and knockdown of endogenous dynamin altered the rate of cargo release from single vesicles. Our data reveal the dynamics of many key proteins involved in exocytosis and identify a rapidly recruited dynamin/PIP2/BAR assembly that regulates the exocytic fusion pore of dense-core vesicles in cultured endocrine beta cells.

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Chen, Yu, Aiwu Shi, Kai He, Zhiqiang Hu e Nan Su. "DCVS A Dynamic Control for Video Traffic in SPICE". Journal of Information Technology Research 11, n. 3 (luglio 2018): 15–28. http://dx.doi.org/10.4018/jitr.2018070102.

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This article describes how with the development of cloud computing and virtualization technology, the desktop virtualization solution is becoming more and more mature. As a virtual desktop transport protocol, SPICE is used for deploying virtual desktops on servers and remote clients with high performance. However, it will take up a lot of network bandwidth and cause network congestion in a relatively poor network environment on video transmission. To solve this problem, a dynamic adjustment for video traffic (DCVS) in SPICE is proposed. It can dynamically adjust the bit rate of the video encoding according to the state of the virtual buffer and the feedback from client. The experiment results prove that DCVS can effectively reduce the video traffic and the probability of congestion.

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Gu, Feifei, Huazhao Cao, Pengju Xie e Zhan Song. "Accurate Depth Recovery Method Based on the Fusion of Time-of-Flight and Dot-Coded Structured Light". Photonics 9, n. 5 (11 maggio 2022): 333. http://dx.doi.org/10.3390/photonics9050333.

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3D vision technology has been gradually applied to intelligent terminals ever since Apple Inc. introduced structured light on iPhoneX. At present, time-of-flight (TOF) and laser speckle-based structured light (SL) are two mainstream technologies applied to intelligent terminals, both of which are widely regarded as efficient dynamic technologies, but with low accuracy. This paper explores a new approach to achieve accurate depth recovery by fusing TOF and our previous work—dot-coded SL (DCSL). TOF can obtain high-density depth information, but its results may be deformed due to multi-path interference (MPI) and reflectivity-related deviations. In contrast, DCSL can provide high-accuracy and noise-clean results, yet only a limited number of encoded points can be reconstructed. This inspired our idea to fuse them to obtain better results. In this method, the sparse result provided by DCSL can work as accurate “anchor points” to keep the correctness of the target scene’s structure, meanwhile, the dense result from TOF can guarantee full-range measurement. Experimental results show that by fusion, the MPI errors of TOF can be eliminated effectively. Dense and accurate results can be obtained successfully, which has great potential for application in the 3D vision task of intelligent terminals in the future.

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Menshenina, A. P., I. A. Goroshinskaya, E. M. Frantsiyants, T. I. Moiseenko, E. V. Verenikina, I. V. Kaplieva e L. A. Nemashkalova. "Effect of dendritic cell vaccine on blood redox status in patients with cervical cancer". Research and Practical Medicine Journal 10, n. 1 (26 marzo 2023): 36–49. http://dx.doi.org/10.17709/2410-1893-2023-10-1-3.

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Purpose of the study. The purpose of the study was to evaluate the dynamics of parameters of malondialdehyde (MDA), reduced glutathione and antioxidant enzyme activity in patients with advanced cervical cancer (CC) receiving anticancer treatment with dendritic cell vaccine (DCV).Patients and methods. Levels of malondialdehyde (MDA), reduced glutathione and antioxidant enzyme activity were studied in 27 patients aged 27–65 years with advanced primary and recurrent CC receiving chemotherapy (CT) with DCV or DCV as monotherapy at a dose of 10 million cells intradermally once a week. The same indices were studied in 20 healthy women from the comparison group.Results. The majority of patients showed the initial increase of MDA: in blood plasma by an average of 66.7 %, in red blood cells – statistically insignificant. After CT, MDA levels were elevated respectively in primary and recurrent patients in erythrocytes by 85.6 % and 96.4 % compared to donors, and by 53.9 % and 33.7 % compared to the initial values; the levels in plasma were elevated by 79.8 % and 57.1 % compared to donors. After 5–7 DCVs in combination with CT, MDA levels in erythrocytes and in blood plasma were similar to the donor values. MDA in erythrocytes of patients receiving DCV without CT decreased by 36 % compared to initial values. Oxidase activity of ceruloplasmin, initially increased by 34.2–57.1 %, normalized after DCV. Superoxide dismutase activity decreased by 16.7–27.3 % after 4–6 DCVs and normalized after 7 DCVs. Catalase activity, initially reduced by more than 40 %, remained 20–38 % lower than the norm at all stages of DCV. In this setting, hydrogen peroxide was probably inactivated by glutathione peroxidase whose activity was increased at all stages of treatment and decreased only when MDA was normalized after 7 DCVs.Conclusion. Administration of 5–7 DCVs in combination with CT or as monotherapy to patients with advanced CC normalizes parameters of free radical oxidation and antioxidant system of the blood.

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Moro, Alessandro, Anne van Nifterick, Ruud F. Toonen e Matthijs Verhage. "Dynamin controls neuropeptide secretion by organizing dense-core vesicle fusion sites". Science Advances 7, n. 21 (maggio 2021): eabf0659. http://dx.doi.org/10.1126/sciadv.abf0659.

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Abstract (sommario):

Synaptic vesicles (SVs) release neurotransmitters at specialized active zones, but release sites and organizing principles for the other major secretory pathway, neuropeptide/neuromodulator release from dense-core vesicles (DCVs), remain elusive. We identify dynamins, yeast Vps1 orthologs, as DCV fusion site organizers in mammalian neurons. Genetic or pharmacological inactivation of all three dynamins strongly impaired DCV exocytosis, while SV exocytosis remained unaffected. Wild-type dynamin restored normal exocytosis but not guanosine triphosphatase–deficient or membrane-binding mutants that cause neurodevelopmental syndromes. During prolonged stimulation, repeated use of the same DCV fusion location was impaired in dynamin 1-3 triple knockout neurons. The syntaxin-1 staining efficiency, but not its expression level, was reduced. αSNAP (α–soluble N-ethylmaleimide–sensitive factor attachment protein) expression restored this. We conclude that mammalian dynamins organize DCV fusion sites, downstream of αSNAP, by regulating the equilibrium between fusogenic and non-fusogenic syntaxin-1 promoting its availability for SNARE (SNAP receptor) complex formation and DCV exocytosis.

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Liao, Haini, Jie Zhang, Svetlana Shestopal, Gabor Szabo, Anna Castle e David Castle. "Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis". American Journal of Physiology-Cell Physiology 294, n. 3 (marzo 2008): C797—C809. http://dx.doi.org/10.1152/ajpcell.00493.2007.

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Five secretory carrier membrane proteins (SCAMP-1, -2, -3, -4, and -5) have been characterized in mammalian cells. Previously, SCAMP-1 and -2 have been implicated to function in exocytosis. RNA inhibitor-mediated deficiency of one or both of these SCAMPs interferes with dense core vesicle (DCV) exocytosis in neuroendocrine PC12 cells as detected by amperometry. Knockdowns of these SCAMPs each decreased the number and frequency of depolarization-induced exocytotic events. SCAMP-2 but not SCAMP-1 depletion also delayed the onset of exocytosis. Both knockdowns, however, altered fusion pore dynamics, increasing rapid pore closure and decreasing pore dilation. In contrast, knockdowns of SCAMP-3 and -5 only interfered with the frequency of fusion pore opening and did not affect the dynamics of newly opened pores. None of the knockdowns noticeably affected upstream events, including the distribution of DCVs near the plasma membrane and calcium signaling kinetics, although norepinephrine uptake/storage was moderately decreased by deficiency of SCAMP-1 and -5. Thus, SCAMP-1 and -2 are most closely linked to the final events of exocytosis. Other SCAMPs collaborate in regulating fusion sites, but the roles of individual isoforms appear at least partially distinct.

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Tesi sul tema "DYNAMIC DCVSL"

TRIVEDI, JAYESH. "LEAKAGE POWER REDUCTION IN DYNAMIC DCVSL USING ONOFIC APPROACH". Thesis, 2017. http://dspace.dtu.ac.in:8080/jspui/handle/repository/16019.

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Differential logic styles have been becoming popular over conventional CMOS logic because of they promise lower power consumption and high computational speed. DCVSL promises the advantages of both traditional CMOS logic and pseudo NMOS logic thus offering high speed area effective rail to rail swing logic option. The dynamic DCVSL logic family has been explored and leakage power and delay has been considered. Various dynamic versions of DCVSL logic have been introduced and their leakage power and delay have been studied. Leakage power is an important issue in dynamic circuits and a leakage control technique (LECTOR) has been explored in context of two variations of dynamic DCVSL structures. The LECTOR technique is applied to other variants of dynamic DCVSL structures and performance in terms of leakage power dissipation, propagation delay time, power delay product, transistor number is examined. In this thesis, a relatively new leakage reduction technique known as ONOFIC technique has been successfully proposed in various DCVSL structures. Various performance related parameters and transistor count has been reported. This thesis includes relative performance comparison of dynamic DCVSL structures in their conventional format and with the introduction of LECTOR and ONOFIC approach. The effectiveness and functionality of all dynamic DCVSL structures and proposed architectures are confirmed through intensive simulations on Symica Design Environment. The structures were implemented using Symica Design Environment (Symica DE) using 90 nm PTM model technology at 1.2V to analyse the variation in leakage power and delay.

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Capitoli di libri sul tema "DYNAMIC DCVSL"

Li, Qingshan, Lei Wang, Hua Chu e Shaojie Mao. "DCISL: Dynamic Control Integration Script Language". In Artificial Intelligence and Computational Intelligence, 241–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-16527-6_31.

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Atti di convegni sul tema "DYNAMIC DCVSL"

Purohit, Sohan, e Martin Margala. "Data driven DCVSL: A clockless approach to dynamic differential circuit design". In 2010 53rd IEEE International Midwest Symposium on Circuits and Systems (MWSCAS). IEEE, 2010. http://dx.doi.org/10.1109/mwscas.2010.5548907.

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