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Articoli di riviste sul tema "Erg3"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 1 febbraio 2022

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1

Khan, Noman Ahmed Jang, Mahmoud Abdallah, Todd W. Gress, and Mohamed Farouq Alsharedi. "Association between estrogen receptor status and Oncotype Dx breast recurrence score." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e12519-e12519. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12519.

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e12519 Background: The 21 gene assay Oncotype Dx Breast Recurrence Score (RS) is currently the standard of care to determine if adjuvant chemotherapy is needed in early stage node negative, hormone receptor positive, HER-2 negative breast cancer. In current American society of clinical oncology (ASCO) guidelines there is little or no benefit of adjuvant chemotherapy in patients older than 50 years whose tumors have Oncotype DX RS <26, and for patients 50 years or less whose tumors have Oncotype DX RS <16. We sought to evaluate the percentage of estrogen receptor (ER) expression as a surr

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2

De Backer, Marianne D., Tatiana Ilyina, Xiao-Jun Ma, Sandy Vandoninck, Walter H. M. L. Luyten, and Hugo Vanden Bossche. "Genomic Profiling of the Response of Candida albicans to Itraconazole Treatment Using a DNA Microarray." Antimicrobial Agents and Chemotherapy 45, no. 6 (June 1, 2001): 1660–70. http://dx.doi.org/10.1128/aac.45.6.1660-1670.2001.

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ABSTRACT The application of genome-wide expression profiling to determine how drugs achieve their therapeutic effect has provided the pharmaceutical industry with an exciting new tool for drug mode-of-action studies. We used DNA chip technology to study cellular responses to perturbations of ergosterol biosynthesis caused by the broad-spectrum antifungal agent itraconazole. Simultaneous examination of over 6,600 Candida albicans gene transcript levels, representing the entire genome, upon treatment of cells with 10 μM itraconazole revealed that 296 genes were responsive. For 116 genes transcri

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3

White, Elizabeth J., Sung Jin Park, Jane A. Foster, and Jan D. Huizinga. "Ether-a-go-go-related gene 3 is the main candidate for the E-4031-sensitive potassium current in the pacemaker interstitial cells of Cajal." American Journal of Physiology-Gastrointestinal and Liver Physiology 295, no. 4 (October 2008): G691—G699. http://dx.doi.org/10.1152/ajpgi.90348.2008.

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The interstitial cells of Cajal (ICC), as pacemaker cells of the gut, contribute to rhythmic peristalsis and muscle excitability through initiation of slow-wave activity, which subsequently actively propagates into the musculature. An E-4031-sensitive K+ current makes a critical contribution to membrane potential in ICC. This study provides novel features of this current in ICC in physiological solutions and seeks to identify the channel isoform. In situ hybridization and Kit immunohistochemistry were combined to assess ether-a-go-go-related gene (ERG) mRNA expression in ICC in mouse jejunum,

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Yu, Li-hua, Xin Wei, Ming Ma, Xiao-jun Chen, and Shuang-bo Xu. "Possible Inhibitory Molecular Mechanism of Farnesol on the Development of Fluconazole Resistance in Candida albicans Biofilm." Antimicrobial Agents and Chemotherapy 56, no. 2 (November 21, 2011): 770–75. http://dx.doi.org/10.1128/aac.05290-11.

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ABSTRACTCandida albicansbiofilm infections are usually treated with azole antifungals such as fluconazole. However, the development of resistance to this drug inC. albicansbiofilms is very common, especially in immunocompromised individuals. The upregulation of the sterol biosynthetic pathway geneERGand the efflux pump genesCDRandMDRmay contribute to this azole tolerance inCandidaspecies. We hypothesize that farnesol, an endogenous quorum sensing molecule with possible antimicrobial properties which is also the precursor of ergosterols inC. albicans, may interfere with the development of fluco

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5

Alcazar-Fuoli, Laura, Emilia Mellado, Guillermo Garcia-Effron, Maria J. Buitrago, Jordi F. Lopez, Joan O. Grimalt, J. Manuel Cuenca-Estrella, and Juan L. Rodriguez-Tudela. "Aspergillus fumigatus C-5 Sterol Desaturases Erg3A and Erg3B: Role in Sterol Biosynthesis and Antifungal Drug Susceptibility." Antimicrobial Agents and Chemotherapy 50, no. 2 (February 2006): 453–60. http://dx.doi.org/10.1128/aac.50.2.453-460.2006.

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ABSTRACT Two erg3 genes encoding C-5 sterol desaturase enzymes (Erg3A and Erg3B) in Aspergillus fumigatus were characterized with respect to their nucleotide sequences and null mutant phenotypes. Targeted disruption of the erg3A and erg3B genes and a double gene knockout, erg3A − erg3B −, showed that they are not essential for A. fumigatus viability. Mutant phenotypes clearly showed that Erg3B is a C-5 sterol desaturase, but no apparent role for Erg3A in A. fumigatus ergosterol biosynthesis was found. Susceptibility to amphotericin B, itraconazole, fluconazole, voriconazole, and ketoconazole w

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6

Baldus, Claudia D., Cornelia Schlee, Julia Thibaut, Sandra Heesch, Arend Bohne, Eckhard Thiel, and Wolf K. Hofmann. "Differential Expression of ERG Isoforms in Acute Myeloid and T-Lymphoblastic Leukemia Is Regulated by DNA-Methylation." Blood 110, no. 11 (November 16, 2007): 2126. http://dx.doi.org/10.1182/blood.v110.11.2126.2126.

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Abstract The oncogenic ETS transcription factor ERG is involved in various cellular pathways including developmental regulation, proliferation, and differentiation. In hematopoiesis ERG plays a specific role during normal T-cell differentiation showing high expression levels in stem cells and down regulation in the progenitor compartment. In this regard, it is intriguing that aberrant expression of ERG was found in a subset of patients with acute T-lymphoblastic leukemia (T-ALL) and was associated with an inferior outcome. Furthermore, high level ERG expression was of adverse prognostic signif

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Martel, Claire M., Josie E. Parker, Oliver Bader, Michael Weig, Uwe Gross, Andrew G. S. Warrilow, Nicola Rolley, Diane E. Kelly, and Steven L. Kelly. "Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans." Antimicrobial Agents and Chemotherapy 54, no. 11 (August 23, 2010): 4527–33. http://dx.doi.org/10.1128/aac.00348-10.

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ABSTRACT Sterol analysis identified four Candida albicans erg3 mutants in which ergosta 7,22-dienol, indicative of perturbations in sterol Δ5,6-desaturase (Erg3p) activity, comprised >5% of the total sterol fraction. The erg3 mutants (CA12, CA488, CA490, and CA1008) were all resistant to fluconazole, voriconazole, itraconazole, ketoconazole, and clotrimazole under standard CLSI assay conditions (MIC values, ≥256, 16, 16, 8, and 1 μg ml−1, respectively). Importantly, CA12 and CA1008 retained an azole-resistant phenotype even when assayed in the presence of FK506, a multidrug efflux inhibitor

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8

Chau, Andrew S., Maya Gurnani, Robyn Hawkinson, Michel Laverdiere, Anthony Cacciapuoti та Paul M. McNicholas. "Inactivation of Sterol Δ5,6-Desaturase Attenuates Virulence in Candida albicans". Antimicrobial Agents and Chemotherapy 49, № 9 (вересень 2005): 3646–51. http://dx.doi.org/10.1128/aac.49.9.3646-3651.2005.

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ABSTRACT Two clinical Candida albicans isolates that exhibited high-level resistance to azoles and modest decreases in susceptibility to amphotericin B were cultured from unrelated patients. Both isolates harbored homozygous nonsense mutations in ERG3, which encodes an enzyme, sterol Δ5,6-desaturase, involved in ergosterol synthesis. Extraction and analysis of the sterols from both isolates confirmed the absence of sterol Δ5,6-desaturase activity. Although the loss of sterol Δ5,6-desaturase activity is known to confer resistance to azoles, this mechanism of resistance has rarely been seen in c

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9

Wimmers, Sönke, Iris Wulfsen, Christiane K. Bauer, and Jürgen R. Schwarz. "Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers." Pfl�gers Archiv European Journal of Physiology 441, no. 4 (January 15, 2001): 450–55. http://dx.doi.org/10.1007/s004240000467.

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Li, Guohui, Wenxuan Fu, Yu Deng, and Yunying Zhao. "Role of Calcium/Calcineurin Signalling in Regulating Intracellular Reactive Oxygen Species Homeostasis in Saccharomyces cerevisiae." Genes 12, no. 9 (August 25, 2021): 1311. http://dx.doi.org/10.3390/genes12091311.

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The calcium/calcineurin signalling pathway is required for cell survival under various environmental stresses. Using Saccharomyces cerevisiae, we explored the mechanism underlying calcium-regulated homeostasis of intracellular reactive oxygen species (ROS). We found that deletion of acyltransferase Akr1 and C-5 sterol desaturase Erg3 increased the intracellular ROS levels and cell death, and this could be inhibited by the addition of calcium. The hexose transporter Hxt1 and the amino acid permease Agp1 play crucial roles in maintaining intracellular ROS levels, and calcium induced the expressi

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11

Sharma, Ruby, Shanti P. Gangwar, and Ajay K. Saxena. "Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence." Acta Crystallographica Section F Structural Biology Communications 74, no. 10 (September 21, 2018): 656–63. http://dx.doi.org/10.1107/s2053230x1801110x.

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ERG3 (ETS-related gene) is a member of the ETS (erythroblast transformation-specific) family of transcription factors, which contain a highly conserved DNA-binding domain. The ETS family of transcription factors differ in their binding to promoter DNA sequences, and the mechanism of their DNA-sequence discrimination is little known. In the current study, crystals of the ETSi domain (the ETS domain of ERG3 containing a CID motif) in space group P41212 and of its complex with the E74 DNA sequence (DNA9) in space group C2221 were obtained and their structures were determined. Comparative structur

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12

Smith, S. J., J. H. Crowley, and L. W. Parks. "Transcriptional regulation by ergosterol in the yeast Saccharomyces cerevisiae." Molecular and Cellular Biology 16, no. 10 (October 1996): 5427–32. http://dx.doi.org/10.1128/mcb.16.10.5427.

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Sterol biosynthesis in the yeast Saccharomyces cerevisiae is an energy-expensive, aerobic process, requiring heme and molecular oxygen. Heme, also synthesized exclusively during aerobic growth, not only acts as an enzymatic cofactor but also is directly and indirectly responsible for the transcriptional control of several yeast genes. Because of their biosynthetic similarities, we hypothesized that ergosterol, like heme, may have a regulatory function. Sterols are known to play a structural role in membrane integrity, but regulatory roles have not been characterized. To test possible regulator

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13

Miyazaki, Taiga, Yoshitsugu Miyazaki, Koichi Izumikawa, Hiroshi Kakeya, Shunichi Miyakoshi, John E. Bennett, and Shigeru Kohno. "Fluconazole Treatment Is Effective against a Candida albicans erg3/erg3 Mutant In Vivo Despite In Vitro Resistance." Antimicrobial Agents and Chemotherapy 50, no. 2 (February 2006): 580–86. http://dx.doi.org/10.1128/aac.50.2.580-586.2006.

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ABSTRACT Candida albicans ERG3 encodes a sterol C5,6-desaturase which is essential for synthesis of ergosterol. Defective sterol C5,6 desaturation has been considered to be one of the azole resistance mechanisms in this species. However, the clinical relevance of this resistance mechanism is still unclear. In this study, we created a C. albicans erg3/erg3 mutant by the “Ura-blaster” method and confirmed the expected azole resistance using standard in vitro testing and the presence of ergosta-7,22-dien-3β-ol instead of ergosterol. For in vivo studies, a wild-type URA3 was placed back into its n

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Hirayama, Tatsuro, Taiga Miyazaki, Makoto Sumiyoshi, Nobuyuki Ashizawa, Takahiro Takazono, Kazuko Yamamoto, Yoshifumi Imamura, et al. "ERG3-Encoding Sterol C5,6-DESATURASE in Candida albicans Is Required for Virulence in an Enterically Infected Invasive Candidiasis Mouse Model." Pathogens 10, no. 1 (December 31, 2020): 23. http://dx.doi.org/10.3390/pathogens10010023.

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Gastrointestinal colonization by Candida species is considered the main source of candidemia. The ERG3 gene in Candida albicans encodes a sterol C5,6-desaturase, which is essential for ergosterol biosynthesis. Although ERG3 inactivation shows reduced virulence in mouse models of disseminated candidiasis, the role of ERG3 in intestinal infections is unknown. Here, we infected mice with the C. albicans strains CAE3DU3 and CAF2-1, containing mutant and wild-type ERG3, respectively, and studied gut infection and colonization by these strains. We found that the CAE3DU3 strain showed reduced coloniz

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15

Yadav, Anamika, Anubhav Singh, Yue Wang, Merlijn HI van Haren, Ashutosh Singh, Theun de Groot, Jacques F. Meis, Jianping Xu, and Anuradha Chowdhary. "Colonisation and Transmission Dynamics of Candida auris among Chronic Respiratory Diseases Patients Hospitalised in a Chest Hospital, Delhi, India: A Comparative Analysis of Whole Genome Sequencing and Microsatellite Typing." Journal of Fungi 7, no. 2 (January 26, 2021): 81. http://dx.doi.org/10.3390/jof7020081.

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Candida auris is a nosocomial pathogen responsible for an expanding global public health threat. This ascomycete yeast has been frequently isolated from hospital environments, representing a significant reservoir for transmission in healthcare settings. Here, we investigated the relationships among C. auris isolates from patients with chronic respiratory diseases admitted in a chest hospital and from their fomites, using whole-genome sequencing (WGS) and multilocus microsatellite genotyping. Overall, 37.5% (n = 12/32) patients developed colonisation by C. auris including 9.3% of the screened p

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Sanglard, Dominique, Françoise Ischer, Tania Parkinson, Derek Falconer, and Jacques Bille. "Candida albicans Mutations in the Ergosterol Biosynthetic Pathway and Resistance to Several Antifungal Agents." Antimicrobial Agents and Chemotherapy 47, no. 8 (August 2003): 2404–12. http://dx.doi.org/10.1128/aac.47.8.2404-2412.2003.

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ABSTRACT The role of sterol mutations in the resistance of Candida albicans to antifungal agents has not been thoroughly investigated. Previous work reported that clinical C. albicans strains resistant to both azole antifungals and amphotericin B were defective in ERG3, a gene encoding sterol Δ5,6-desaturase. It is also believed that a deletion of the lanosterol 14α-demethylase gene, ERG11, is possible only under aerobic conditions when ERG3 is not functional. We tested these hypotheses by creating mutants by targeted deletion of the ERG3 and ERG11 genes and subjecting those mutants to antifun

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Lo, Hsiu-Jung, Jang-Shiun Wang, Chih-Yang Lin, Chia-Geun Chen, Ting-Yin Hsiao, Chia-Tung Hsu, Chia-Li Su, Ming-Ji Fann, Yu-Tai Ching, and Yun-Liang Yang. "Efg1 Involved in Drug Resistance by Regulating the Expression of ERG3 in Candida albicans." Antimicrobial Agents and Chemotherapy 49, no. 3 (March 2005): 1213–15. http://dx.doi.org/10.1128/aac.49.3.1213-1215.2005.

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ABSTRACT The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.

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Xia, Zhikuan, Haiying Yu, Congmin Wang, Xiao Ding, Dequan Zhang, Xinyu Tan, Jianghan Chen, Songnian Hu, and Rongya Yang. "Genomic and transcriptome identification of fluconazole-resistant genes for Trichosporon asahii." Medical Mycology 58, no. 3 (August 22, 2019): 393–400. http://dx.doi.org/10.1093/mmy/myz088.

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Abstract Trichosporon asahii infection is difficult to control clinically. This study identified a case with over 15 years of T. asahii infection-related systemic dissemination disease and conducted genome and transcriptome sequencing to identify fluconazole-resistant genes in fluconazole-resistant versus susceptible strains isolated from this patient's facial skin lesions. The data revealed mutations of the ergosterol biosynthetic pathway-related genes in the T. asahii genome of the fluconazole-resistant strain, that is, there were 36 novel mutations of the ERG11 gene, three point mutations (

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Simons, Veronika, John P. Morrissey, Maita Latijnhouwers, Michael Csukai, Adam Cleaver, Carol Yarrow, and Anne Osbourn. "Dual Effects of Plant Steroidal Alkaloids on Saccharomyces cerevisiae." Antimicrobial Agents and Chemotherapy 50, no. 8 (August 2006): 2732–40. http://dx.doi.org/10.1128/aac.00289-06.

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ABSTRACT Many plant species accumulate sterols and triterpenes as antimicrobial glycosides. These secondary metabolites (saponins) provide built-in chemical protection against pest and pathogen attack and can also influence induced defense responses. In addition, they have a variety of important pharmacological properties, including anticancer activity. The biological mechanisms underpinning the varied and diverse effects of saponins on microbes, plants, and animals are only poorly understood despite the ecological and pharmaceutical importance of this major class of plant secondary metabolite

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Papa, Michele, Francesca Boscia, Adriana Canitano, Pasqualina Castaldo, Stefania Sellitti, Lucio Annunziato, and Maurizio Taglialatela. "Expression pattern of the ether-a-gogo-related (ERG) k+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system." Journal of Comparative Neurology 466, no. 1 (September 19, 2003): 119–35. http://dx.doi.org/10.1002/cne.10886.

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Simone, Polvani, Masi Alessio, Pillozzi Serena, Gragnani Laura, Crociani Olivia, Olivotto Massimo, Becchetti Andrea, Wanke Enzo, and Arcangeli Annarosa. "Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3." Gene Expression Patterns 3, no. 6 (December 2003): 767–76. http://dx.doi.org/10.1016/s1567-133x(03)00124-8.

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Liu, Teresa T., Robin E. B. Lee, Katherine S. Barker, Richard E. Lee, Lai Wei, Ramin Homayouni, and P. David Rogers. "Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans." Antimicrobial Agents and Chemotherapy 49, no. 6 (June 2005): 2226–36. http://dx.doi.org/10.1128/aac.49.6.2226-2236.2005.

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ABSTRACT Antifungal agents exert their activity through a variety of mechanisms, some of which are poorly understood. We examined changes in the gene expression profile of Candida albicans following exposure to representatives of the four currently available classes of antifungal agents used in the treatment of systemic fungal infections. Ketoconazole exposure increased expression of genes involved in lipid, fatty acid, and sterol metabolism, including NCP1, MCR1, CYB5, ERG2, ERG3, ERG10, ERG25, ERG251, and that encoding the azole target, ERG11. Ketoconazole also increased expression of severa

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Davies, Brandon S. J., Helen S. Wang, and Jasper Rine. "Dual Activators of the Sterol Biosynthetic Pathway of Saccharomyces cerevisiae: Similar Activation/Regulatory Domains but Different Response Mechanisms." Molecular and Cellular Biology 25, no. 16 (August 15, 2005): 7375–85. http://dx.doi.org/10.1128/mcb.25.16.7375-7385.2005.

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ABSTRACT Genes encoding biosynthetic enzymes that make ergosterol, the major fungal membrane sterol, are regulated, in part, at the transcriptional level. Two transcription factors, Upc2p and Ecm22p, bind to the promoters of most ergosterol biosynthetic (ERG) genes, including ERG2 and ERG3, and activate these genes upon sterol depletion. We have identified the transcriptional activation domains of Upc2p and Ecm22p and found that UPC2-1, a mutation that allows cells to take up sterols aerobically, increased the potency of the activation domain. The equivalent mutation in ECM22 also greatly enha

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Lotfali, Ensieh, Ali Ghajari, Parivash Kordbacheh, Farideh Zaini, Hossein Mirhendi, Rasoul Mohammadi, Fatemeh Noorbakhsh, and Sassan Rezaie. "Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis." Iranian Biomedical Journal 21, no. 4 (July 1, 2017): 275–81. http://dx.doi.org/10.18869/acadpub.ibj.21.4.275.

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Vik, Åshild, and Jasper Rine. "Upc2p and Ecm22p, Dual Regulators of Sterol Biosynthesis in Saccharomyces cerevisiae." Molecular and Cellular Biology 21, no. 19 (October 1, 2001): 6395–405. http://dx.doi.org/10.1128/mcb.21.19.6395-6405.2001.

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ABSTRACT Sterol levels affect the expression of many genes in yeast and humans. We found that the paralogous transcription factors Upc2p and Ecm22p of yeast were sterol regulatory element (SRE) binding proteins (SREBPs) responsible for regulating transcription of the sterol biosynthetic genes ERG2 and ERG3. We defined a 7-bp SRE common to these and other genes, including many genes involved in sterol biosynthesis. Upc2p and Ecm22p activatedERG2 expression by binding directly to this element in the ERG2 promoter. Upc2p and Ecm22p may thereby coordinately regulate genes involved in sterol homeos

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Anderson, James B., Caroline Sirjusingh, Ainslie B. Parsons, Charles Boone, Claire Wickens, Leah E. Cowen, and Linda M. Kohn. "Mode of Selection and Experimental Evolution of Antifungal Drug Resistance in Saccharomyces cerevisiae." Genetics 163, no. 4 (April 1, 2003): 1287–98. http://dx.doi.org/10.1093/genetics/163.4.1287.

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Abstract We show that mode of selection, degree of dominance of mutations, and ploidy are determining factors in the evolution of resistance to the antifungal drug fluconazole in yeast. In experiment 1, yeast populations were subjected to a stepwise increase in fluconazole concentration over 400 generations. Under this regimen, two mutations in the same two chromosomal regions rose to high frequency in parallel in three replicate populations. These mutations were semidominant and additive in their effect on resistance. The first of these mutations mapped to PDR1 and resulted in the overexpress

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Yu, Lu, Wenliang Zhang, Lingling Wang, Jian Yang, Tao Liu, Junping Peng, Wenchuan Leng, Lihong Chen, Ruoyu Li, and Qi Jin. "Transcriptional Profiles of the Response to Ketoconazole and Amphotericin B in Trichophyton rubrum." Antimicrobial Agents and Chemotherapy 51, no. 1 (October 23, 2006): 144–53. http://dx.doi.org/10.1128/aac.00755-06.

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ABSTRACT Trichophyton rubrum is a pathogenic filamentous fungus of increasing medical concern. Two antifungal agents, ketoconazole (KTC) and amphotericin B (AMB), have specific activity against dermatophytes. To identify the mechanisms of action of KTC and AMB against T. rubrum, a cDNA microarray was constructed from the expressed sequence tags of the cDNA library from different developmental stages, and transcriptional profiles of the responses to KTC and AMB were determined. T. rubrum was exposed to subinhibitory concentrations of KTC and AMB for 12 h, and microarray analysis was used to exa

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Anderson, James B., Nicole Ricker, and Caroline Sirjusingh. "Antagonism between Two Mechanisms of Antifungal Drug Resistance." Eukaryotic Cell 5, no. 8 (August 2006): 1243–51. http://dx.doi.org/10.1128/ec.00048-06.

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ABSTRACT This study tested for interaction between two independently evolved mechanisms of fluconazole resistance in Saccharomyces cerevisiae. One set of strains was from a 400-generation evolution experiment, during which the concentration of fluconazole was increased from 16 to 256 μg/ml in four increments. At 100 generations, populations became fixed for resistance mutations in either of two transcriptional regulators, PDR1 or PDR3. At 400 generations, replicate populations became fixed for another resistance mutation in UNK1, an unmapped gene further increasing resistance. Another genotype

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Schledermann, Wiebke, Iris Wulfsen, Jürgen R. Schwarz, and Christiane K. Bauer. "Modulation of rat erg1, erg2, erg3 and HERG K + currents by thyrotropin‐releasing hormone in anterior pituitary cells via the native signal cascade." Journal of Physiology 532, no. 1 (April 2001): 143–63. http://dx.doi.org/10.1111/j.1469-7793.2001.0143g.x.

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OuYang, Qiuli, Yangmei Liu, Okwong Reymick Oketch, Miaoling Zhang, Xingfeng Shao, and Nengguo Tao. "Citronellal Exerts Its Antifungal Activity by Targeting Ergosterol Biosynthesis in Penicillium digitatum." Journal of Fungi 7, no. 6 (May 29, 2021): 432. http://dx.doi.org/10.3390/jof7060432.

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Ergosterol (ERG) is a potential target for the development of antifungal agents against Penicillium digitatum, the pathogen of green mold in citrus fruits. This study examined the mechanism by which citronellal, a typical terpenoid of Cymbopogon nardus essential oil, acts on ergosterol to exhibit its antifungal activity against P. digitatum. We previously reported that citronellal inhibited the growth of P. digitatum with minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of 1.36 and 2.72 mg/mL, respectively. In citronellal-treated cells, the membrane integrity a

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Cowen, Leah E., Anne E. Carpenter, Oranart Matangkasombut, Gerald R. Fink, and Susan Lindquist. "Genetic Architecture of Hsp90-Dependent Drug Resistance." Eukaryotic Cell 5, no. 12 (October 20, 2006): 2184–88. http://dx.doi.org/10.1128/ec.00274-06.

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ABSTRACT Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.

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Young, Laura Y., Christina M. Hull, and Joseph Heitman. "Disruption of Ergosterol Biosynthesis Confers Resistance to Amphotericin B in Candida lusitaniae." Antimicrobial Agents and Chemotherapy 47, no. 9 (September 2003): 2717–24. http://dx.doi.org/10.1128/aac.47.9.2717-2724.2003.

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ABSTRACT Candida lusitaniae is an emerging human pathogen that, unlike other fungal pathogens, frequently develops resistance to the commonly used antifungal agent amphotericin B. Amphotericin B is a member of the polyene class of antifungal drugs, which impair fungal cell membrane integrity. Here we analyzed mechanisms contributing to amphotericin B resistance in C. lusitaniae. Sensitivity to polyenes in the related fungi Saccharomyces cerevisiae and Candida albicans requires the ergosterol biosynthetic gene ERG6. In an effort to understand the mechanisms contributing to amphotericin B resist

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33

Markovich, Sarit, Aya Yekutiel, Itamar Shalit, Yona Shadkchan, and Nir Osherov. "Genomic Approach to Identification of Mutations Affecting Caspofungin Susceptibility in Saccharomyces cerevisiae." Antimicrobial Agents and Chemotherapy 48, no. 10 (October 2004): 3871–76. http://dx.doi.org/10.1128/aac.48.10.3871-3876.2004.

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ABSTRACT The antifungal agent caspofungin (CAS) specifically interferes with glucan synthesis and cell wall formation. To further study the cellular processes affected by CAS, we analyzed a Saccharomyces cerevisiae mutant collection (4,787 individual knockout mutations) to identify new genes affecting susceptibility to the drug. This collection was screened for increased CAS sensitivity (CAS-IS) or increased CAS resistance (CAS-IR). MICs were determined by the broth microdilution method. Disruption of 20 genes led to CAS-IS (four- to eightfold reductions in the MIC). Eleven of the 20 genes are

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34

Kang, Jiesheng, Xiao-Liang Chen, and David Rampe. "The Antipsychotic Drugs Sertindole and Pimozide Block erg3, a Human Brain K+ Channel." Biochemical and Biophysical Research Communications 286, no. 3 (August 2001): 499–504. http://dx.doi.org/10.1006/bbrc.2001.5434.

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35

Klein, E. A., S. M. Falzarano, T. Maddala, D. Cherbavaz, W. F. Novotny, C. Millward, and C. Magi-Galluzzi. "Use of TMPRSS2-ERG gene rearrangement and quantitative ERG expression to predict clinical recurrence after radical prostatectomy." Journal of Clinical Oncology 29, no. 7_suppl (March 1, 2011): 36. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.36.

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36 Background: The association of TMPRSS2-ERG fusions and ERG expression in prostate cancer (PC) with adverse clinical outcomes has been controversial, with mixed results in the literature. We conducted a study to test whether tumor-derived gene expression profiles, including the presence of TMPRSS2-ERG fusions and ERG gene expression, are associated with clinical recurrence (cR) after radical prostatectomy (RP). Methods: All patients with clinical stage T1/T2 prostate cancer treated with RP at CC from 1987 to 2004 were identified (n∼f2,600). A cohort sampling design was used to select 127 pat

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36

Smooha, Gil, Yehudit Birger, Liat Goldberg, Jasmine Jacob-Hirsch, Ninette Amariglio, Gideon Rechavi, Ditsa Levanon, et al. "MODELING and Targeting ERG-INDUCED Acute MYELOID LEUKEMIA (AML)." Blood 114, no. 22 (November 20, 2009): 475. http://dx.doi.org/10.1182/blood.v114.22.475.475.

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Abstract Abstract 475 ERG is an oncogene located on the long arm of human chromosome 21 that encodes an ETS transcription factor that has been reported to be involved in normal and aberrant megakaryopoiesis (Salek-Ardakani et al Cancer Res. 2009;69:4665; Stankiewicz et al Blood 2009;113:3337). High ERG expression has also been reported associated with poor prognosis of cytogenetically normal AML (Marcucci et al J Clin Oncol. 2007;25:3337). Thus, deciphering the molecular targets and oncogenic pathways activated by overexpressed ERG protein is likely to lead to more effective therapy for ERG-re

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37

Morio, F., F. Pagniez, C. Lacroix, M. Miegeville, and P. Le Pape. "Implication des mutations sur le gène erg3 dans la résistance de Candida albicans aux antifongiques azoles." Journal de Mycologie Médicale 22, no. 1 (March 2012): 118. http://dx.doi.org/10.1016/j.mycmed.2011.12.059.

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38

Xiao, Kuo, Zhiming Sun, Xueqin Jin, Weining Ma, Yan Song, Shirong Lai, Qian Chen, et al. "ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice." Journal of Physiology 596, no. 19 (September 7, 2018): 4729–52. http://dx.doi.org/10.1113/jp275970.

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39

Brumfield, Kristy M., James V. Moroney, Thomas S. Moore, Tiffany A. Simms, and David Donze. "Functional Characterization of the Chlamydomonas reinhardtii ERG3 Ortholog, a Gene Involved in the Biosynthesis of Ergosterol." PLoS ONE 5, no. 1 (January 11, 2010): e8659. http://dx.doi.org/10.1371/journal.pone.0008659.

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40

Dewhurst-Maridor, Gisèle, Daniel Abegg, Fabrice P. A. David, Jacques Rougemont, Cameron C. Scott, Alexander Adibekian, and Howard Riezman. "The SAGA complex, together with transcription factors and the endocytic protein Rvs167p, coordinates the reprofiling of gene expression in response to changes in sterol composition inSaccharomyces cerevisiae." Molecular Biology of the Cell 28, no. 20 (October 2017): 2637–49. http://dx.doi.org/10.1091/mbc.e17-03-0169.

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Changes in cellular sterol species and concentrations can have profound effects on the transcriptional profile. In yeast, mutants defective in sterol biosynthesis show a wide range of changes in transcription, including a coinduction of anaerobic genes and ergosterol biosynthesis genes, biosynthesis of basic amino acids, and several stress genes. However the mechanisms underlying these changes are unknown. We identified mutations in the SAGA complex, a coactivator of transcription, which abrogate the ability to carry out most of these sterol-dependent transcriptional changes. In the erg3 mutan

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41

Miyazaki, Yoshitsugu, Antonia Geber, Haruko Miyazaki, Derek Falconer, Tanya Parkinson, Christopher Hitchcock, Brian Grimberg, Katherine Nyswaner, and John E. Bennett. "Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicans." Gene 236, no. 1 (August 1999): 43–51. http://dx.doi.org/10.1016/s0378-1119(99)00263-2.

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42

Brumfield, Kristy M., James V. Moroney, Thomas S. Moore, Tiffany A. Simms, and David Donze. "Correction: Functional Characterization of the Chlamydomonas reinhardtii ERG3 Ortholog, a Gene Involved in the Biosynthesis of Ergosterol." PLOS ONE 10, no. 5 (May 28, 2015): e0129189. http://dx.doi.org/10.1371/journal.pone.0129189.

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43

Ahmad, Suhail, Leena Joseph, Josie E. Parker, Mohammad Asadzadeh, Steven L. Kelly, Jacques F. Meis, and Ziauddin Khan. "ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait." Antimicrobial Agents and Chemotherapy 63, no. 2 (November 19, 2018): e01900-18. http://dx.doi.org/10.1128/aac.01900-18.

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Abstract (sommario):

ABSTRACT Candida glabrata is intrinsically less susceptible to azoles, and resistance to echinocandins and reduced susceptibility (RS) to amphotericin B (AMB) have also been detected. The molecular mechanisms of RS to AMB were investigated in C. glabrata strains in Kuwait by sequence analyses of genes involved in ergosterol biosynthesis. A total of 1,646 C. glabrata isolates were tested by Etest, and results for 12 selected isolates were confirmed by reference broth microdilution. PCR sequencing of three genes (ERG2, ERG6, and ERG11) was performed for all isolates with RS to AMB (RS-AMB isolat

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44

Laborenz, Janina, Katja Hansen, Cristina Prescianotto-Baschong, Anne Spang, and Johannes M. Herrmann. "In vitro import experiments with semi-intact cells suggest a role of the Sec61 paralog Ssh1 in mitochondrial biogenesis." Biological Chemistry 400, no. 9 (August 27, 2019): 1229–40. http://dx.doi.org/10.1515/hsz-2019-0196.

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Abstract (sommario):

AbstractMitochondrial biogenesis relies on the synthesis of hundreds of different precursor proteins in the cytosol and their subsequent import into the organelle. Recent studies suggest that the surface of the endoplasmic reticulum (ER) actively contributes to the targeting of some mitochondrial precursors. In the past,in vitroimport experiments with isolated mitochondria proved to be extremely powerful to elucidate the individual reactions of the mitochondrial import machinery. However, thisin vitroapproach is not well suited to study the influence of non-mitochondrial membranes. In this stu

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45

Sharma, Ruby, Shanti P. Gangwar, and Ajay K. Saxena. "Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence. Corrigendum." Acta Crystallographica Section F Structural Biology Communications 75, no. 5 (April 29, 2019): 397–98. http://dx.doi.org/10.1107/s2053230x19003376.

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46

Branco, J., M. Ola, R. M. Silva, E. Fonseca, N. C. Gomes, C. Martins-Cruz, A. P. Silva, et al. "Impact of ERG3 mutations and expression of ergosterol genes controlled by UPC2 and NDT80 in Candida parapsilosis azole resistance." Clinical Microbiology and Infection 23, no. 8 (August 2017): 575.e1–575.e8. http://dx.doi.org/10.1016/j.cmi.2017.02.002.

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47

Hood, Donald C., William Seiple, Karen Holopigian, and Vivienne Greenstein. "A comparison of the components of the multifocal and full-field ERGs." Visual Neuroscience 14, no. 3 (May 1997): 533–44. http://dx.doi.org/10.1017/s0952523800012190.

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Abstract (sommario):

AbstractThe multi-input technique of Sutter and Tran (1992) yields multiple focal ERGs. The purpose here was to compare the components of this multifocal ERG to the components of the standard, full-field ERG. To record multifocal ERGs, an array of 103 hexagons was displayed on a monitor. Full-field (Ganzfeld) ERGs were elicited by flashes presented upon steady background fields. The latencies of two prominent subcomponents of the full-field ERG were altered by varying the intensity of the incremental flash or the intensity of the background field. By showing that similar manipulations of the m

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48

Geber, A., C. A. Hitchcock, J. E. Swartz, F. S. Pullen, K. E. Marsden, K. J. Kwon-Chung, and J. E. Bennett. "Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility." Antimicrobial Agents and Chemotherapy 39, no. 12 (December 1, 1995): 2708–17. http://dx.doi.org/10.1128/aac.39.12.2708.

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49

Arthington-Skaggs, B. A., D. N. Crowell, H. Yang, S. L. Sturley, and M. Bard. "Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway." FEBS Letters 392, no. 2 (August 26, 1996): 161–65. http://dx.doi.org/10.1016/0014-5793(96)00807-1.

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50

Feng, Wenli, Jing Yang, Zhiqin Xi, Ying Ji, Xin Zhu, Lu Yang, and Yan Ma. "Regulatory Role of ERG3 and Efg1 in Azoles-Resistant Strains of Candida albicans Isolated from Patients Diagnosed with Vulvovaginal Candidiasis." Indian Journal of Microbiology 59, no. 4 (November 2, 2019): 514–24. http://dx.doi.org/10.1007/s12088-019-00833-x.

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