Tesi: "ERx" – Grafiati

1

Miček, David. "Genetické algoritmy". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-218215.

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This thesis presents description of Genetic algorithm. The description begins with theory of complexity and following basic theory of genetic algorithm. Next part explains the principle of all three tasks – travelling salesman problem, knapsack problem and evolution of algorithm for five-in-a-row. The main focus was on developing the algorithm for five-in-a-row. The results were tested with other similar algorithms from internet. In case of travelling salesman problem and knapsack problem, the results were compared with gradient optimization methods.

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2

Delcour, Clémence. "Exploration des mécanismes étiopathogéniques des pathologies de la puberté". Electronic Thesis or Diss., Université Paris Cité, 2024. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=6023&f=74391.

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Le développement de l'axe gonadotrope (HHG) débute pendant la vie foetale mais ne s'achève qu'une fois la puberté terminée. De nombreux acteurs interviennent à chaque étape et le défaut de l'un d'entre eux peut mener à des pathologies de la puberté ou des troubles de la fertilité à l'âge adulte. Les facteurs génétiques ont une place centrale dans le développement de l'axe HHG et l'étude génétique des pathologies de la puberté a permis des avancées majeures dans la compréhension des mécanismes moléculaires sous-jacents, bien qu'il subsiste toujours de nombreuses inconnues. Pour mon travail de thèse, j'ai choisi d'explorer la génétique des maladies de la puberté afin de mieux comprendre les mécanismes étiopathogéniques de ces maladies complexes. Dans un premier temps, j'ai eu l'opportunité d'étudier une famille consanguine au sein de laquelle deux soeurs présentaient une absence de puberté associée à une augmentation des concentrations d'oestradiol et des gonadotrophines. Nous avons mis en évidence un variant rare à l'état homozygote dans le récepteur alpha de l'oestradiol (ERalpha). L'étude in vitro du récepteur muté a montré une diminution de son activité régulatrice sur un promoteur contenant des éléments de réponse à l'oestradiol ainsi qu'une activation paradoxale ligand-indépendante du promoteur de KISS1. L'étude de ces cas permet de mieux comprendre les conséquences des mutations perte de fonction de ERalpha ainsi que les mécanismes de régulation exercés par l'oestradiol via ERalpha. Dans un second temps, je me suis intéressée à la génétique de la puberté précoce centrale (PPC) et particulièrement au gène MKRN3 (Makorin ring finger protein 3) puisqu'il s'agit de la cause génétique la plus fréquente de la PPC. MKRN3 est un gène soumis à empreinte maternel dont la fonction protéique n'est pas connue. La détermination de la pathogénicité des variants faux-sens associés à la PPC repose presque exclusivement sur les analyses in silico. Dans cette partie de mon travail, j'ai montré que les outils usuels d'analyse in silico ne sont pas performants pour déterminer la pathogénicité des variants faux-sens rares de MKRN3. J'ai également proposé une nouvelle approche pour annoter la pathogénicité des variants basée sur l'analyse de la contrainte mutationnelle de MKRN3 et la conservation des acides aminés au sein de la famille des protéines MKRN. Les PPC avec transmission maternelle représentent la majorité des PPC familiales et ne sont pas expliquées par une mutation de MKRN3. J'ai cherché à identifier de nouveaux gènes impliqués dans la PPC de transmission maternelle, en partant de l'hypothèse qu'il pourrait exister un gène majeur selon un modèle monogénique. Pour cela, j'ai sélectionné 27 patients provenant de 18 familles chez qui l'analyse d'un panel de gènes associés à la PPC n'était pas contributive. L'analyse des variants sur les régions codantes combinée à l'analyse des variations du nombre de copies (CNV) sur l'ensemble du génome m'a permis d'identifier des gènes candidats dont la fréquence a été évaluée sur une cohorte réplicative de 48 patients par séquençage à haut débit (NGS). Cette analyse n'a pas permis d'identifier un gène majeur. Toutefois, nous avons identifié des variants perte de fonction dans deux gènes pour lesquels l'analyse de l'expression hypothalamique chez la souris a montré une diminution pendant la phase juvénile, suggérant leur implication dans le contrôle post-natal de la maturation de l'axe HHG. Cette troisième partie indique que la PPC est une maladie génétique complexe. Ce travail de thèse permet de mieux comprendre les conséquences cliniques et biologiques de la perte de fonction de ERalpha. Il confirme la complexité du contrôle génétique du développement et de la maturation de l'axe HHG. Finalement, il montre que l'annotation des variants pour les maladies de la puberté est complexe et que les analyses in-silico actuelles ne sont pas adaptées à l'étude de la PPC
The development of the gonadotropic axis (HHG) begins during fetal life but is not completed until puberty. Numerous players are involved at each stage, and a defect in any one of them can lead to pubertal pathologies or fertility disorders in adulthood. Genetic factors play a central role in the development of the HHG axis, and the genetic study of pubertal pathologies has led to major advances in our understanding of the underlying molecular mechanisms, although there are still many unknowns. For my thesis work, I chose to explore the genetics of pubertal diseases in order to better understand the etiopathogenic mechanisms of these complex disorders. First, I had the opportunity to study a consanguineous family in which two sisters showed an absence of puberty associated with increased concentrations of estradiol and gonadotropins. We identified a rare homozygous variant in the estradiol receptor alpha (ERalpha). In vitro study of the mutated receptor showed a decrease of its regulatory activity on a promoter containing Estradiol Response Elements, as well as a paradoxical ligand-independent activation of the KISS1 promoter. The study of these cases provides a better understanding of the consequences of ERalpha loss-of-function mutations and the regulatory mechanisms exerted by estradiol via ERalpha. Next, I focused on the genetics of central precocious puberty (CPP), and in particular the MKRN3 (Makorin ring finger protein 3) gene, since its mutations are the most common genetic cause of CPP. MKRN3 is a maternally imprinted gene whose protein function is unknown. Determining the pathogenicity of CPP-associated missense variants relies almost exclusively on in silico analyses. In this part of my work, I have shown that the usual in silico analysis tools do not efficiently determine the pathogenicity of rare MKRN3 missense variants. I have also proposed a new approach to annotate the pathogenicity of variants based on the analysis of MKRN3 mutational constraint and amino acid conservation within the MKRN protein family. Maternally inherited CPP accounts for the majority of familial CPP and is not explained by a mutation in MKRN3. I aimed to identify new genes involved in maternally inherited CPP, based on the hypothesis that a major gene might exist in a monogenic model. For this purpose, I selected 27 patients from 18 families in whom analysis of a panel of genes associated with CPP was non-contributory. Analysis of variants in coding regions combined with genome-wide copy number variation (CNV) analysis led to the identification of candidate genes whose frequency was assessed on a replicative cohort of 48 patients by high-throughput sequencing (NGS). This analysis failed to identify a major gene. However, we did identify loss-of-function variants in two genes for which mouse hypothalamic expression analysis showed a decrease during the juvenile phase, suggesting their involvement in the post-natal control of HHG axis maturation. This study shows that CPP is a complex genetic disease. My research provides a better understanding of the clinical and biological consequences of loss of ERalpha function. It confirms the complexity of genetic control of development and maturation of the HHG axis. Finally, it shows that the annotation of variants for pubertal diseases is complex and that current in-silico analyses are not adapted to the study of CPP

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3

Bonifácio, Paulo Ricardo Corrêa. "Estudo da sincronização e dessincronização cortical em EEG associada a movimento de membros inferiores". Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/3/3142/tde-05092006-143720/.

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Bonifácio, P.R.C. Estudo da sincronização e dessincronização cortical em EEG associada a movimento de membros inferiores. 84 f. Dissertação (Mestrado) Escola Politécnica, Universidade de São Paulo, São Paulo, 2006. Quando o ser humano prepara a execução de um movimento conhecido e treinado, é possível identificar as fases desta preparação no sinal eletrencefalográfico (EEG), sobre as faixas de freqüência delta, mu, beta e gama. A preparação do movimento dos membros inferiores pode ser antecipada em milhares de milissegundos e a facilitação descendente no sistema nervoso central pode ser identificada. Este trabalho sistematiza um processo de aquisição para o sinal de preparação motora baseado no EEG, em área associada a membros inferiores, como subsídio à identificação de Sincronização e Dessincronização corticais, nas faixas de freqüência acima de 13Hz, como reflexo da interação funcional de alças córtico-talâmicas, para movimento conhecido e treinado, em tarefa de retardo instruído. Buscou-se comprovar a possibilidade de uso de um número reduzido de cinco canais de EEG para monitorar esta preparação cortical, bem como formalizar a possibilidade de usar o sinal processado nas faixas beta e gama. Foram obtidos resultados coerentes com a literatura, com dessincronização mu e beta com todos os sujeitos e sincronização gama evidenciada em metade dos sujeitos. Como resultado principal ficou evidenciado que: o uso de cinco canais suportando a coleta de EEG apresenta-se cabível e possui uma boa capacidade de discriminação dos fenômenos de ERS/ERD nas faixas de interesse, para o monitoramento da atividade cortical pré-movimento para membros inferiores; que é possível identificar, no paradigma empregado, os períodos de envio de informação para os tratos descendentes, e quais são as condições mínimas para realizar o monitoramento com a preparação ambiental adequada para evitar os distratores mais conhecidos.
The analysis of the electroencephalogram (EEG) enables the identification of a pre-movement activity associated with the execution of a known and pre-trained movement. The main frequency bands to achieve this identification are the delta, mu, beta and gamma. The initiation of the movement of the legs can be anticipated by thousands of milliseconds by a suitable analysis of the EEG. The objective of this work is to develop signal acquisition and signal processing methodologies associated with the scalp EEG during pre-movement trials. The EEG recordings are concentrated over the leg cortical area with the objective of identifying cortical synchronization and desynchronization (ERS/ERD) associated with trained movements. The number of available EEG channels was limited to five and one task was to investigate if this low number of channels would be enough for the purposes of monitoring cortical preparation. The results were consistent with those presented in the literature. In all subjects mu and beta desynchronization were observed and in half (four) of them the gamma band showed synchronization. One conclusion was that the cortical ERS/ERD associated with the lower limbs are recognizable using only five EEG channels. Several aspects of the experimental paradigm and the signal processing were adjusted for optimal results. members, foot, leg.

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4

Pinhão, Sara Filipa Pereira. "Neurociência aplicada à comunicação: avaliação do impacto das campanhas publicitárias sobre a emoção de voluntários saudáveis". Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6284.

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Dissertação de Mestrado em Engenharia Biomédica, realizada no Laboratório de Processamento de Imagens e Sinais da Universidade Federal do Rio de Janeiro, para obtenção do título de Mestre em Engenharia Biomédica na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa
Neste estudo foi investigado o impacto da atenção e emocional dos anúncios publicitários através da aplicação de técnicas de processamento digital de sinais EEG. Os sinais EEG de 32 voluntários saudáveis foram adquiridos durante 300s de olhos fechados (OF) e durante a visualização de um filme composto por trechos de um documentário e por seis anúncios de diversos produtos. Com base nas respostas ao questionário, no qual os sujeitos emitiram a sua opinião, foram seleccionados o anúncio B (EVB) e o anúncio C (EVC) para análise por serem,respectivamente, o que menos gostaram e despertou emoções negativas ou o preferido e,portanto, o que despertou emoções positivas. A análise de sincronismo entre os sinais de EEG da actividade durante a estimulação (EVB e EVC) e a actividade de olhos fechados (OF), em torno de ±1Hz do pico de ALFA (BPA) para as derivações parieto-temporo-occipitais, foi realizada utilizando-se o índice event related dessynchronization / synchronization, ERD/ERS(f). Por um lado, os resultados do índice ERD/ERS(f), para α=0,05 com correcção de Bonferroni, e do Teste de Wilcoxon (α=0,05) indicaram dessincronismo na BPA com distribuição topográfica homogénea, tanto para EVB como EVC. Por outro lado, o Teste de Wilcoxon aplicado ao grau médio de sincronismo da BPA, indicou somente as regiões parieto-temporais esquerdas como as de maior dessincronismo quando os sujeitos eram estimulados pelo anúncio C, ou seja, o anúncio preferido e considerado pelos mesmos como de impacto emocional mais positivo. Tais resultados indicam a potencialidade do uso do índice ERD/ERS(f) na avaliação da resposta electrofisiológica cortical à publicidade e propaganda, em particular no que concerne à ligação emocional.

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5

Giroux, Véronique. "Rôle de la famille des récepteurs à l'oestrogène dans l'épithélium intestinal et les pathologies associées". Thèse, Université de Sherbrooke, 2013. http://hdl.handle.net/11143/6659.

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Plusieurs études animales et cellulaires suggèrent un rôle protecteur pour l’oestrogène dans les maladies inflammatoires intestinales. L'oestrogène agit principalement via l’interaction avec ses récepteurs ER? et ER?. Puisqu'ER? est l’isoforme prédominant dans l'épithélium colique, celui-ci devrait y être le médiateur des effets de l'oestrogène. Dans cette étude, nous avons tout d'abord démontré que la perte d’ER? chez la souris augmente les signes d'inflammation dans un modèle murin de colite. Également, l’activation sélective d’ER? avec le diarylpropionitrile (DPN) réduit les signes de colite dans le même modèle. L'expression de la cytokine inflammatoire TNF? était réduite alors que celle des cytokines anti-inflammatoires TGF?1, TGF?2 et TGF?3 était augmentée dans le côlon des souris traitées au DPN. Des études réalisées dans les cellules cancéreuses du côlon LS1034 ont démontré que le DPN augmente la signalisation du TGF? et que cette régulation contribue en partie à l’effet anti-inflammatoire du DPN dans ces mêmes cellules. Bref, ces résultats suggèrent que l'activation pharmacologique d’ER? réduit l’inflammation intestinale en partie via la régulation de la voie du TGF? dans les cellules épithéliales intestinales. Le récepteur nucléaire ERR?, un régulateur clé du métabolisme énergétique, possède une forte homologie avec les ERs bien que celui-ci ne peut lier l’oestrogène. Son activité est plutôt régulée par la disponibilité des coactivateurs ainsi que par des modifications post-traductionnelles. La découverte d'un variant d'épissage pour ERR? (ERR? ?5) a soulevé un nouveau mécanisme de régulation d'ERR?. En effet, puisqu'ERR? ?5 ne pourrait interagir avec les coactivateurs, il pourrait donc agir comme dominant négatif sur l’activité d'ERR?. Dans cette étude, nous avons démontré qu'ERR? et ERR? ?5 colocalisent au noyau en plus d’interagir physiquement De plus, ERR? ?5 réduit l'activité transcriptionnelle d'ERR? ainsi que l'expression de ses gènes cibles. Tout comme ERR?, ERR? ?5 est exprimé dans une multitude de lignées normales et cancéreuses du côlon ainsi que dans des cellules ou tissus provenant de d'autres organes et de d’autres espèces animales. Par contre, la protéine ERR? ?5 est exprimée plus faiblement qu'ERR? puisqu’elle est instable et rapidement dégradée par le protéasome. Néanmoins, la surexpression d'ERR? ?5 réduit la croissance cellulaire et possiblement l'adhésion cellulaire. Bref, nos résultats démontrent qu’ERR? ?5 agit comme dominant négatif sur ERR? et que son expression transitoire pourrait donc affecter l’activité d'ERR? ainsi que ses fonctions biologiques. [symboles non conformes]

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6

Cederberg, Lisa. "Felaktig alternativ splicing: Vissa mutationer i BRCA1, BRCA2, ERα och ERβ är starkt förknippade med bröstcancer". Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-69551.

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Alternative splicing is a process that partly rejects the common definition of a gene – that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. Alternative splicing is an important condition for the development of complex life forms, but it is also a highly sensitive process and inaccurate splicing is the cause of approximately 15 % of mutations that cause genetic diseases. This article presents four genes, BRCA1, BRCA2, ERα and ERβ, and inaccurate splicing of these genes increases the risk of developing cancer, particularly breast cancer and ovarian cancer. Breast cancer is the second most common form of lethal cancer among women. After identifying the cancerogenic mutations, women of high-risk families can undergo genetic testing and preventive therapy can reduce the morbidity and mortality. The article also presents a short discussion around the ethical problems of genetic testing, and the social and psychological dilemmas women of high-risk families are facing when they are given the option to undergo genetic testing.

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7

Pecorelli, Margherita. "Effetti della tDCS sui pattern ERS/ERD indotti da immaginazione motoria: stato dell'arte". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11307/.

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I sistemi BCI EEG-based sono un mezzo di comunicazione diretto tra il cervello e un dispositivo esterno il quale riceve comandi direttamente da segnali derivanti dall'attività elettrica cerebrale. Le features più utilizzate per controllare questi dispositivi sono i ritmi sensorimotori, ossia i ritmi mu e beta (8-30 Hz). Questi ritmi hanno la particolare proprietà di essere modulati durante l'immaginazione di un movimento generando così delle desincronizzazioni e delle sincronizzazioni evento correlate, ERD e ERS rispettavamente. Tuttavia i destinatari di tali sistemi BCI sono pazienti con delle compromissioni corticali e non sono sempre in grado di generare dei pattern ERD/ERS stabili. Per questo motivo, negli ultimi anni, è stato proposto l'uso di tecniche di stimolazione cerebrale non invasiva, come la tDCS, da abbinare al training BCI. In questo lavoro ci si è focalizzati sugli effetti della tDCS sugli ERD ed ERS neuronali indotti da immaginazione motoria attraverso un'analisi dei contributi presenti in letteratura. In particolare, sono stati analizzati due aspetti, ossia: i) lo studio delle modificazioni di ERD ed ERS durante (online) o in seguito (offline) a tDCS e ii) eventuali cambiamenti in termini di performance/controllo del sistema BCI da parte del soggetto sottoposto alla seduta di training e tDCS. Le ricerche effettuate tramite studi offline o online o con entrambe le modalità, hanno portato a risultati contrastanti e nuovi studi sarebbero necessari per chiarire meglio i meccanismi cerebrali che sottendono alla modulazione di ERD ed ERS indotta dalla tDCS. Si è infine provato ad ipotizzare un protocollo sperimentale per chiarire alcuni di questi aspetti.

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8

Pugazhendhi, Dhamayanthi. "Role of ERα and ERβ in oestrogen action in human breast cancer cells". Thesis, University of Reading, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494000.

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The role of ERα in hormone responsive breast cancer is well established but that of ERβ remains to be determined. In this thesis, the effects of overexpression of ERβlong have been studied in MCF7 human breast cancer cells which possess high endogenous levels of ERα . Stable overexpression of ERβlong protein (2-fold) resulted in reduced fold induction (from 2.6 to 1.8) of an ERE-CAT reporter gene with 10-8M 17β-oestradiol but enhanced fold induction (from 1.18 to 2.12) by 10-5M genistein and an increased induction (from 4.4 to 11.4) of growth with 10-4M methylparaben.

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9

Cerri, Marion. "Régulation et fonctions de facteurs de transcription ERF ERN au cours de la symbiose entre Medicago truncatula et Sinorhizobium meliloti". Thesis, Toulouse, INSA, 2013. http://www.theses.fr/2013ISAT0042/document.

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Les légumineuses sont capables de s’associer en symbiose avec des bactéries du sol Rhizobium. Cette interaction culmine par la formation d’un nouvel organe racinaire appelé nodule, à l’intérieur duquel les bactéries différentiées fixent l’azote atmosphérique sous une forme assimilable par la plante hôte. La mise en place de cette association repose sur un dialogue moléculaire entre les deux partenaires, faisant intervenir des signaux bactériens lipo-chitooligosaccharidiques appelés Facteurs Nod (FNods). Chez la légumineuse modèle Medicago truncatula, la perception de ces signaux symbiotiques au niveau de l’épiderme racinaire, initie une voie de signalisation qui conduit à des oscillations calciques nécessaires pour l`activation de gènes de la plante hôte, tel le gène marqueur ENOD11. Il a été montré que les facteurs de transcription ERF ERN1/ERN2, étroitement apparentés, agissent comme des activateurs directs de la transcription d’ENOD11, via leur liaison à la séquence cis régulatrice NFbox. Le mutant ern1 est de manière cohérente requis pour l’activation d’ENOD11 en réponse aux FNods mais également au cours des étapes suivantes d’infection et de développement nodulaire. Cependant, ce mutant présente un phénotype symbiotique partiel soulevant la question d’une redondance fonctionnelle, qui pourrait être attribuée à la présence du facteur ERN2, étroitement apparenté. Ainsi, au cours de ma thèse, j’ai étudié la relation fonctionnelle entre les facteurs ERN1/ERN2 par de approches diverses visant à déterminer leur expression et fonctions relatives au cours de la symbiose rhizobienne. Mon travail de thèse a dans tout d’abord porté sur l’étude des profils d’expression spatio-temporels de gènes ERN au cours de la symbiose rhizobienne, corroborée par la dynamique de localisation cellulaire des protéines de fusions ERN. Ces facteurs sont exprimés de manière séquentielle mais aussi conjointe aux cours de la signalisation FNods et l’infection rhizobienne. Par la suite, des expériences de complémentation croisée, dans le fond mutant ern1, ont montré qu’ERN2 peut remplacer ERN1 pour l’induction d’ENOD11 en réponse aux FNods et pour la formation de nodules, dès lors qu’il est exprimé sous le contrôle du promoteur d’ERN1. Ceci indique que ces facteurs ont des activités biologiques similaires et suggère que l’absence de complémentation d’ern1 par le facteur endogène ERN2 est probablement liée à une régulation transcriptionnelle différentielle de la part de leurs promoteurs. Enfin, nous avons initié la caractérisation phénotypique de nouvelles lignées mutées au niveau du gène ERN2, dans le but d’identifier les fonctions spécifiques de ce facteur au cours de la nodulation. A travers l’analyse d’une lignée Tilling (ern2.1) présentant une mutation ponctuelle dans le domaine de liaison à l’ADN, nous avons mis en évidence un rôle d’ERN2 dans la progression des cordons d’infection au niveau du cortex racinaire. Des études moléculaires ont permis de montrer que l’acide aminé muté est un résidu conservé et important pour la topologie du domaine de liaison à l’ADN, mais également pour l’activité transcriptionnelle d’ERN2 sur ENOD11. Contrairement à ern1, le mutants ern2.1 et ern2.2 (mutant d’insertion) sont capables de former des nodules. Néanmoins, l’infection nodulaire apparait dans les deux cas parfois défectueuse, conduisant à une sénescence précoce. Ces résultats démontrent qu’ERN2 remplit aussi des rôles spécifiques au cours de la nodulation, qui ne sont pas entièrement complémentés par ERN1. Il semblerait donc que les facteurs ERN contrôlent des étapes communes et divergentes de l‘infection rhizobienne, ERN1 ayant un rôle prépondérant dans l`initiation et progression de l’infection tandis qu’ERN2 aurait un rôle secondaire, plus centré dans la progression des cordons. La lignée double mutant ern1ern2.1, ouvre de nouvelles perspectives pour l’étude de la redondance fonctionnelle entre ces deux facteurs au cours des symbioses racinaires
Legumes are able to associate in symbiosis with Rhizobia bacteria in the soil, which culminates in the formation of a new organ referred to as the root nodule, within which differentiated bacteria fix nitrogen to the benefit of the host plant. The establishment of this association relies on a molecular dialogue between the two partners, involving bacterial lipo-chitooligosaccharide signals called Nod factors (NF). In the model legume Medicago truncatula, the perception of these symbiotic signals in the root epidermis, initiates a signaling pathway that leads to calcium oscillation responses required for the activation of downstream genes such as the well-characterized ENOD11. Previously, ERN1 and the closely-related ERN2 transcription factors (TFs) were reported as direct activators of ENOD11 via binding to the NFbox regulatory unit. In addition, phenotypic analysis of the ern1 knockout mutant has confirmed the importance of ERN1 not only during NF signaling but also throughout subsequent infection and nodule development stages. Nevertheless, the ern1 mutant displays a less severe phenotype compared to plants mutated in other NF signaling genes, raising the question of a possible functional redundancy with the endogenous closely-related ERN2 factor. My PhD project was focused on the study of the functional relationship between ERN1 and ERN2 TFs. By using a variety of strategies we aimed at determining both ERN expression profiles and relative functions during nodulation. We first examined the spatio-temporal expression profiles of these genes during rhizobial symbiosis and correlated this with the dynamics of cellular localization of ERN fusion proteins. These analyses revealed that these factors possess both common and distinct expression profiles, correlated with cell-type specific and dynamic in vivo protein accumulation, tightly associated with rhizobial pre-infection and subsequent infection stages in M. truncatula. Further cross-complementation studies in the ern1 mutant background showed that, when ERN2 is expressed under the control of the ERN1 promoter, it can fully restore the ern1 phenotype regarding NF-elicited ENOD11 activation and nodule formation. This indicates that these factors have similar biological activities and suggests that the incapacity of endogenous ERN2 to complement the ern1 mutant is mainly due to differences in their promoter activities. Finally, we also initiated a phenotypic characterization of M. truncatula ern2 mutant lines, in order to get a better insight into ERN2 specific functions during nodulation. The phenotypic analysis of a Tilling line (ern2.1) carrying a point mutation in a conserved amino acid in the ERN2 DNA binding domain, revealed a role for ERN2 during infection thread progression in the root cortex. Further molecular studies demonstrated that this mutated amino acid in the Tilling line is conserved and required for optimal DNA binding domain topology and transcriptional activity of ERN2 on its target ENOD11 gene. In addition, the ern2.1 line and a second ern2.2 insertional mutant line are both capable of forming nodules, in contrast to the ern1 mutant. Nevertheless, these nodules are partly infection defective leading to premature senescence. These findings provide evidence that ERN2 possesses specialized functions during nodulation that cannot be fully complemented by ERN1. This suggests that ERN possess common and divergent functions, ERN1 having a predominant role in rhizobial infection initiation and progression while ERN2 having a secondary and more centered role during infection thread progression. The ern1ern2.1 double mutant line, recently generated during my PhD, opens new perspectives to further study the functional relationship between ERN TFs during root endosymbioses

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10

Mattsson, Anna. "Roles of ERα and ERβ in Normal and Disrupted Sex Differentiation in Japanese Quail". Doctoral thesis, Uppsala universitet, Ekotoxikologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8921.

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Exposure to xenoestrogens during development has been shown to impair sexual differentiation in various species. The major aim of this thesis was to elucidate the respective roles of the two estrogen receptors ERα and ERβ in normal and disrupted differentiation of sex organs and copulatory behavior in the Japanese quail (Coturnix japonica). The expression of ERα mRNA was much stronger than that of ERβ mRNA in the gonads and Müllerian ducts (embryonic oviducts) in early embryos. By contrast, ERβ seemed to be predominantly expressed in regions of the embryonic brain that are associated with male sexual behavior. Embryos were exposed to the selective ERα agonists propyl-pyrazole-triol (PPT) and 16α-lactone-estradiol (16α-LE2). The estrogens 17β-estradiol (E2) and 17α-ethynylestradiol (EE2), which activate both ERα and ERβ, were used as positive controls. All substances impaired reproductive organ differentiation. The effects observed included oviductal malformations in females and partial development of oviducts in males. All substances also induced testis feminization (ovotestis) in male embryos. The male copulatory behavior was severely impaired by the positive controls but was unaffected by PPT and 16α-LE2 at doses that disrupted sex organ differentiation. A higher dose of 16α-LE2 significantly suppressed the behavior. However, it is possible that this effect was caused by cross-activation of ERβ. The substances also induced hepatic expression of mRNA encoding the egg-yolk proteins vitellogenin II and very low-density apolipoprotein II, which are commonly used as indicators of estrogen exposure. In conclusion, the results suggest that ERα is important for female reproductive organ differentiation. Excess activation of ERα by xenoestrogens impairs differentiation in both females and males and induces hepatic expression of egg-yolk proteins. The results also indicate that ERα alone cannot mediate demasculinization of male copulatory behavior in quail, although further studies are needed to test this hypothesis.

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11

Emil, Živkov. "Razvoj modela internih kontrolnih mehanizama u funkciji upravljanja preduzećem". Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2015. http://www.cris.uns.ac.rs/record.jsf?recordId=94923&source=NDLTD&language=en.

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Kvalitetna postavka kombinacije internih kontrolnih mehanizama, u značajnoj meri oredeljuje i kvalitet samog kontrolnog okruženja preduzeća. Ovim istraživanjem je potvrđena činjenica da kvalitetno kontrolno okruženje značajno doprinosi dobrom upravljanju ciljevima i rizicima. Centralno mesto u procesu korporativnog upravljanja zauzimaju interni kontrolni mehanizmi koncentrisani u procesu upravljanja rizicima. Interni kontrolni mehanizmi upotrebom svojih kontrolnih „alata“, olakšavaju procenu rizika, njegovo prepoznavanje i merenje. Svako iz svog ugla: računovodstvo, kontroling, Fast Close, ERP (Enterprise Resource Planning ), IMS (Integrisani sistemi menadžmenta) , finansijsko upravljanje i kontrola, ERM (Enterprise Risk Management) i interna revizija, su značajni elementi internih kontrolnih mehanizama, u procesu
Creating a right combination of internal control mechanisms, to a large extent, also determines the quality of a company’s control environment. This research has confirmedthe fact that an efficient control environment significantly contributes to proper management of goals and risks. The central place in the process of corporate governance belongs to internal control mechanisms centered in the process of risk management. Internal control mechanisms, by using their control "tools", facilitate the risk assessment, its identification and measurement. Everyone from their own perspective: accounting, controlling, Fast Close, ERP (Enterprise Resource Planning), IMS (Integrated Management Systems), financial management and control, ERM (Enterprise Risk Management) and internal audit, are important elements of internal control mechanisms in the process of managing the key financial and operational risks.

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12

Hertrampf, Torsten. "Analyse molekularer Mechanismen der ERα- und ERβ-vermittelten Wirkung spezifischer Liganden und des Phytoestrogens Genistein". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1180003908058-30532.

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Die Behandlung menopausaler und postmenopausaler Beschwerden ist mit einem erhöhten Risiko verbunden, an Mamma- und Endometriumskarzinomen zu erkranken. Darüber hinaus zeigen epidemiologische Studien, dass in ostasiatischen Ländern postmenopausale Beschwerden, osteoporotische Frakturen und Herz-Kreislauferkrankungen seltener auftreten als in westlichen Ländern. Vor diesem Hintergrund war es Ziel der Untersuchungen dieser Arbeit, in dem Tiermodell der ovarektomierten Ratte die mögliche Bedeutung von estrogenrezeptorsubtypspezifischen Einflüssen für hormonell bedingte Erkrankungen und Beschwerden zu untersuchen. Hierbei sollten gewebespezifische Wirkungen estrogenrezeptorsubtypspezifischer Liganden untersucht und explizit die Bedeutung der Estrogenrezeptorsubtypen ERα und ERβ bei der Gewebehomöostase in Knochen und Darm analysiert werden. Darüber hinaus sollten vor dem Hintergrund estrogenrezeptorsubtypspezifischer Wirkungsweisen gewebespezifische Einflüsse des Phytoestrogens Genistein (Gen) näher charakterisiert werden. Es konnte gezeigt werden, dass nach einer subkutanen Applikation der knochenprotektive Einfluss von Gen mit dem von Estradiol (E2) vergleichbar ist, durch die Kombination mit Bewegung verstärkt wird und über den ERα vermittelt zu sein scheint. Es zeigte sich außerdem, dass der stimulierende Einfluss von E2 auf den motorischen Antrieb ERα-vermittelt ist und ERβ-spezifische Liganden ebenso wie Gen diesen Effekt antagonisieren. Des Weiteren wurde deutlich, dass E2, nicht aber Gen über den ERα Einfluss auf die Körperfettverteilung nimmt. Mit einer phytoestrogenreichen Diät konnten in adulten Ratten physiologisch relevante Gen/Dai-Plasmaspiegel erreicht werden, allerdings blieben hierbei die nach einer subkutanen Applikation beobachteten knochenprotektiven Effekte dieser Phytoestrogene aus. Bei der näheren Betrachtung der Gewebehomöostase im Dünndarm zeigte sich, dass über den im Darm verstärkt exprimierten ERβ antiproliferative und proapoptotische Effekte vermittelt werden und Gen in diesem Gewebe wie ein ERβ-spezifischer Agonist wirkt. Bezogen auf eine hormonell bedingte Osteoporose, wie sie bei einem Großteil postmenopausaler Frauen auftritt, scheint das Phytoestrogen Genistein eine mögliche Alternative zur Hormonersatztherapie darzustellen. Außerdem zeigt sich, dass Genistein gewebe- und estrogenrezeptorsubtypspezifische antagonistische und agonistische Einflüsse hat und somit die Charakterisierung als „Phyto-SERMs“ (pflanzlicher selektiver Estrogenrezeptormodulator) zutreffend ist. Sollten sich in weiterführenden Studien die beobachteten Effekte im Dünndarm auch für die Gewebehomöostase im Kolon beschreiben lassen, können vor diesem Hintergrund Genistein und ERβ-spezifische Liganden für die Darmkrebsprävention diskutiert werden…

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Soares, Jackeline Cintra. "Composição fenólica e atividade biológica in vitro e in vivo de frutas nativas brasileiras". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/11/11141/tde-21062018-134748/.

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O Brasil possui condições climáticas adequadas para o desenvolvimento de um grande número de frutas nativas e essa biodiversidade tem se tornado um caminho promissor para a descoberta de novos compostos bioativos capazes de ser utilizados na formulação de alimentos funcionais e medicamentos. Os compostos fenólicos apresentam ações específicas, podendo atuar como antioxidantes e anti-inflamatórios, assim prevenindo doenças crônicas. Diante do exposto, o objetivo deste trabalho foi avaliar o potencial antioxidante, antiinflamatório e a composição fenólica de dez frutas nativas brasileiras ainda pouco conhecidas: araçá-boi (Eugenia stipitata), cambuití-cipó (Sagerectia elegans), murici vermelho (Bysonima arthropoda), murici guassú (Byrsonima lancifolia), morango silvestre (Rubus rosaefolius), cambuci (Campomanesia phaea), jaracatiá-mamão (Jacaratia spinosa), juquirioba (Solanum alterno-pinatum), fruta-do-sabiá (Acnistus arborescens) e cajá (Spondias mombin L.). Os extratos etanólicos (80% v/v) das polpas foram analisados inicialmente quanto à capacidade de sequestro dos radicais ABTS∙+ e ROO∙. A atividade anti-inflamatória foi avaliada in vivo por meio do modelo de migração de neutrófilos induzida por carragenina, enquanto que a composição fenólica foi realizada por técnicas cromatográficas (CLAE-DAD e CG-EM). As 5 frutas com as maiores atividades biológicas foram ainda analisadas quanto à capacidade de sequestro de O2 ∙-, HOCl e NO∙, atividade anti-inflamatória por meio do ensaio de ativação do fator nuclear-κB (NF-κB) e composição fenólica por espectrometria de massas de alta resolução (LC-ESI-QTOF-MS). Em relação ao sequestro do radical ABTS∙+ o cambuití-cipó apresentou a maior atividade (749,88 μmol TE.g-1) e para o ROO∙ o murici vermelho apresentou a maior atividade antioxidante (559,09 μmol TE.g-1). Os animais tratados com araçá-boi, cambuití-cipó, murici vermelho, cajá e morango silvestre apresentaram reduções no influxo de neutrófilos comparados ao grupo carragenina (p < 0,05). Por meio das técnicas de CLAE-DAD e CG-EM foi possível identificar compostos fenólicos pertencentes a classe dos flavonoides (catequina, epicatequina, rutina, quercetina glicosilada, kaempeferol glicosilado, quercetina, procianidina B1 e procianidina B2), sub-classe do ácido hidroxibenzóico (ácido gálico) e sub-classe dos ácidos hidrocinâmicos (ácido cumárico, ácido ferúlico e caféico). O araçá-boi, cambuití-cipó, murici vermelho, morango silvestre e cajá foram as cinco frutas que apresentaram as maiores atividades antioxidantes e/ou anti-inflamatórias, cujo perfil fenólico por LC-ESI-QTOF-MS indicou a presença de 18 compostos no araçá-boi, 32 no cambuitícipó, 26 no murici vermelho e 20 e 11 compostos no morango silvestre e cajá, respectivamente. Vários dos compostos fenólicos identificados foram encontrados pela primeira vez nessas espécies. O cambuiti-cipó e murici vermelho se destacaram em relação ao sequestro de HOCl (EC50 4,99 e 4,41 μg mL-1, respectivamente) e o cambuití-cipó foi o mais ativo para desativar o radical O2 ∙- (EC50 68,33 μg mL-1) e NO∙ (EC50 0,78 μg mL-1). Já os extratos de murici-vermelho, cambuití-cipó e morango silvestre inibiram significativamente a ativação do NF-κB. Portanto, as frutas nativas brasileiras são fontes de substâncias antioxidantes e anti-inflamatórias, bem como de uma grande diversidade de compostos fenólicos, os quais podem propiciar importantes benefícios para a saúde humana.
Brazil has favorable climatic conditions for the development of a large number of native fruits and this biodiversity has become a promising path towards the discovery of new bioactive compounds capable of being used in the formulation of functional foods and medicines. Phenolic compounds show specific action mechanisms, being able to act as antioxidants and anti-inflammatories, thus preventing chronic diseases. However, few Brazilian native fruits are well known and consumed by the population, undermining the investigation of chemical composition as well as the identification/quantification of bioactive compounds. In light of this, the objective of this work was to evaluate the antioxidant and anti-inflammatory potentials as well as the phenolic composition of ten underexploited Brazilian native fruits, namely: araçá-boi (Eugenia stipitata), cambuití-cipó (Sagerectia elegans), murici vermelho (Bysonima arthropoda), murici guassu (Byrsonima lancifolia), morango silvestre (Rubus rosaefolius), cambuci (Campomanesia phaea), jaracatiá-mamão (Jacaratia spinosa), juquirioba (Solanum alterno-pinatum), fruto-do-sabiá (Acnistus arborescens) and cajá (Spondias mombin L.). Pulps ethanolic extracts (80%, v/v) were initially analyzed regarding scavenging capacity of the ABTS∙+ and ROO∙ radicals. Antiinflammatory activity was evaluated in vivo using the carrageenan-induced neutrophil migration model, while phenolic composition was determined by chromatographic techniques (HPLC-PAD and GC-MS). The five fruits with the highest biological activities were analyzed for O2∙-, HOCl and NO∙ radicals scavenging capacities, for in vitro anti-inflammatory activity by nuclear factor-κB (NF-κB) activation, and for phenolic composition by High Resolution Mass Spectrometry (LC-ESI-QTOF-MS). In relation to ABTS∙+ radical scavenging cambuiticipó showed the highest activity (749.88 μmol TE.g-1), while for ROO∙ scavenging, murici vermelho had the highest antioxidant activity (559.09 μmol TE.g-1). The animals treated with araçá-boi, cambuití-cipó, murici vermelho, cajá and morango silvestre reported decreases in neutrophils influx compared to carrageenan group (p <0.05). It was possible to identify by HPLC-DAD and GC-MS techniques phenolic compounds belonging to the class of flavonoids (catechin, epicatechin, rutin, glycosylated quercetin, glycosylated kaempeferol, quercetin, procyanidin B1 and procyanidin B2), subclass of hydroxybenzoic acid (gallic acid) and subclass of hydrocinnamic acids (coumaric, ferulic and caffeic acids). Araçá-boi, cambuitícipó, murici vermelho, morango silvestre and cajá were the five fruits with the highest antioxidant and / or anti-inflammatory activities. The phenolic profile analysis by LC-ESIQTOF- MS pointed the presence of 18 compounds in araçá-boi, 32 in cambuití-cipó, 26 in murici vermelho, 20 in morango silvestre and 11 in cajá. Several of the identified phenolic compounds were found for the first time in these fruit species. Cambuiti-cipó and murici vermelho stood out in relation to HOCl scavenging (EC50 4.99 and 4.41 μg.mL-1, respectively) and cambuití-cipó was the most active to deactivate both O2 ∙- radical (EC50 68.33 μg.mL-1) as NO∙ (EC 500.78 μg.mL-1). Murici vermelho, cambuití-cipó and morango silvestre extracts significantly inhibited the activation of NF- κB.Therefore, Brazilian native fruits are sources of antioxidant and anti-inflammatory substances, as well as a great diversity of phenolic compounds, which can provide important benefits for human health.

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Souza, Bianca Ribeiro de [UNESP]. "Avaliação histopatológica e imuno-histoquímica dos ovários de ratas tratadas com o esteroide decanoato de nandrolona associado à melatonina". Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151646.

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Os esteroides anabólicos androgênicos são prescritos para o tratamento de várias doenças, porém apresentam efeitos colaterais mesmo em dosagens terapêuticas. Entre eles, destaca-se o decanoato de nandrolona (DN), o qual age sobre receptores de andrógenos (AR) e estrógenos (ERα e ERβ). Paralelamente, a melatonina (MLT) tem despertado a atenção na área da saúde devido às suas propriedades antioxidantes e profiláticas, com o intuito de reduzir ou suprimir os efeitos colaterais promovidos por fármacos. Então, o presente estudo teve por objetivo avaliar o ciclo estral, a estrutura histológica e a imunomarcação para AR, ERα e ERβ em ovários de ratas androgenizadas submetidas ao tratamento com MLT. Ratas Wistar (n = 8/grupo) receberam óleo mineral (Controle), DN (7,5 mg/kg; via subcutânea, 15 dias) e o tratamento com MLT (10 mg/kg; via intraperitoneal, 7 dias) isoladamente, previamente ou concomitantemente ao esteroide. O ciclo estral foi monitorado. Os ovários foram coletados e preparados para a avaliação do tecido. Nas ratas androgenizadas, a MLT recuperou o peso e o tecido ovariano, mas não restabeleceu o ciclo estral. O número e área dos corpos lúteos dos animais que receberam MLT, previamente ou concomitantemente ao DN, foram similares ao controle, e apenas o tratamento prévio restabeleceu a quantidade de folículos saudáveis e atrésicos. Nos folículos, a MLT promoveu uma fraca expressão do ERα e ERβ, e nos corpos lúteos inibiu a diminuição na expressão de ERβ induzido pelo DN. O tratamento prévio com MLT atenuou o aumento na expressão do AR promovido pelo DN em folículos atrésicos e corpos lúteos. Em conclusão, a MLT apresentou efeito benéfico nos ovários androgenizados através da recuperação da foliculogênese e da luteogênese. O tratamento prévio com melatonina foi mais eficaz em relação ao tratamento concomitante.
Androgenic anabolic steroids are prescribed as treatment to several diseases, however, they present side effects even in therapeutic dosages. Among them, we highlight the nandrolone decanoate (ND) which acts on androgen receptors (AR) and estrogen receptors (ERα e ERβ). At the same time, melatonin (MLT) has raised attention in health area due to its antioxidant and prophylactic properties intending reduction or surpassing side effects caused by medicine. Thus, the present study aimed assess the estrous cycle, histological structure and AR, ERα and ERβ immunolocalization in androgenized rats ovaries undergone treatment with MLT. Wistar rats (n= 8/group) received mineral oil (Control), ND (7,5 mg/kg; subcutaneously, 15 days) and treatment with MLT (10 mg/kg; intraperitoneally, 7 days) singly, previously or concomitantly to steroid. Estrous cycle was monitored. The ovaries were collected and prepared for tissue assessment. In androgenized rats, MLT recovered weight and ovarian tissue, but it did not reestablish the estrous cycle. The number and area of corpus luteum of animals which received MLT, previously or concomitantly to ND, were similar to control, and only previous treatment reestablished the quantity of healthy and atretic follicles. In follicles, MLT promoted a weak expression of the ERα and ERβ, and in corpora lutea, it inhibited the decrease in the ERβ expression induced by ND. Previous treatment with MLT mitigated the increase in AR expression promoted by ND in atretic follicles and corporea lutea. In conclusion, melatonin presented a beneficial effect on the androgenized ovaries through the recovery of the folliculogenesis and luteogenesis. The previous treatment was the most effective.

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Lafront, Camille. "Les récepteurs aux estrogènes ERa et ERb comme cibles thérapeutiques pour le cancer de la prostate". Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/67576.

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Román, Pérez Erick. "The role of ERa, ERß and phytoestrogens from soy in P53-mediated response to DNA damage in mammary epithelium". Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/dissertations/AAI3372274/.

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Thesis (Ph. D.)--University of Massachusetts Amherst, 2009.
On title page, the 'a' in ERa is symbolized by the Greek symbol for alpha. Includes bibliographical references (p. 108-124). Print copy also available.

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Dix, Annika. "Count on the brain". Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17411.

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Wir können Mathematikleistungen über fluide Intelligenz (FI) vorhersagen. Der Einfluss von FI auf kognitive Prozesse und neuronale Mechanismen, die mathematischen Fähigkeiten in verschiedenen Teildisziplinen zugrunde liegen, ist jedoch wenig verstanden. Vorliegende Arbeit spezifiziert FI-bezogene Unterschiede in diesen Prozessen und Mechanismen beim Lösen von Geometrie-, Arithmetik- und Algebra-Aufgaben. Mithilfe eines multimethodalen Ansatzes beleuchtet sie das Zusammenspiel zwischen FI, Leistung und Faktoren wie Aufgabenkomplexität, Lernen und Strategiewahl, die kognitive Prozesse und Anforderungen beim Problemlösen beeinflussen. Leistungsunterschiede wurden durch Messung von Reaktionszeiten und Fehlerraten, Strategien durch Augenbewegungsanalyse erfasst. Als Indikator kortikaler Aktivität diente die ereigniskorrelierte (De-)Synchronisation (ERD/ERS) im Alpha-Band. Um kognitive Prozesse zu unterscheiden, haben wir die ERD/ERS im Theta-Band und den Alpha-Unterbändern einbezogen. Beim Lösen unvertrauter geometrischer Analogien zeichnete sich hohe FI durch verstärkte Verarbeitung visuell-räumlicher Informationen zum Repräsentieren von Merkmalszusammenhängen aus. Schüler mit hoher FI passten ihre Strategiewahl den Anforderungen flexibler an. Erstmals konnten wir durch trialweise Identifikation von Strategien FI-bezogene Unterschiede in der neuronalen Effizienz der Strategieausführung feststellen. Beim Lösen vertrauter arithmetischer und algebraischer Terme zeigten sich bei Schülern mit hoher im Vergleich zu Schülern mit durchschnittlicher FI geringere Anforderungen zur Aktualisierung numerischer Repräsentationen und eine bessere Leistung in komplexen Aufgaben. Weitere Analysen legen nahe, dass Schüler mit hoher FI Zusammenhänge in der Aufgabenstruktur besser erkennen und passende Routinen abrufen können. Die Fähigkeit Zusammenhangsrepräsentationen zu bilden könnte demnach ein Schlüsselaspekt zur Erklärung FI-abhängiger Unterschiede in mathematischen Fähigkeiten sein.
Fluid intelligence (FI) is a strong predictor of mathematical performance. However, the impact of FI on cognitive processes and neural mechanisms underlying differences in mathematical abilities across different subdivisions is not well understood. The present work specifies FI-related differences in these processes and mechanisms for students solving geometric, arithmetic, and algebraic problems. We chose a multi-methodological approach to shed light on the interplay between FI, performance, and factors such as task complexity, learning, and strategy selection that influence cognitive processes and task demands in problem-solving. We measured response times and error rates to evaluate performance, eye movements to identify solution strategies, and the event-related (de-)synchronization (ERD/ERS) in the broad alpha band as indicator of general cortical activity. Further, we considered the ERD/ERS in the theta band and the alpha sub-bands to distinguish between associated cognitive processes. For unfamiliar geometric analogy tasks, students with high FI built relational representations based on a more intense processing of spatial information. Strategy analyses revealed a more adaptive strategy choice in response to increasing task demands compared to students with average FI. Further, we conducted the first study identifying strategies and related cortical activity trial-wise and thereby identified FI-related differences in the neural efficiency of strategy execution. For solving familiar arithmetic and algebraic problems, high compared to average FI was associated with lower demands on the updating of numbers leading to a better performance in complex tasks. Further analyses suggest that students with high FI had an advantage to identify the relational structure of the problems and to retrieve routines that match this structure. Thus, the ability to build relational representations might be one key aspect explaining FI-related difference in mathematical abilities.

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Platt, Allan Augusto. "ERP". Florianópolis, SC, 2004. http://repositorio.ufsc.br/xmlui/handle/123456789/88058.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Engenharia de Produção
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O desenvolvimento da tecnologia da informação e dos sistemas de informação trouxe uma nova forma de planejamento, controle e tomada de decisões para as organizações. Neste contexto, o ERP (enterprise resource planning), um sistema de informações integrado, surge como uma oportunidade para os gestores conduzirem seus negócios com informações em tempo real. Ao mesmo tempo, a expansão do número de universidades brasileiras aumentou a

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Radil, Lukáš. "Model akumulace velkých objemů energie". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217632.

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The purpose of this pursuit is to introduce the reader about the questions of the accumulation of the electric energy and to outline possibilities of its design and what instruments is possible to get it. The other purpose is to inscribe possibilities of today´s attachment of dispersive sources to the net from the sight of the ERU, eventually from the sight of the UCTE. This persuit describes the posibility of the accumulation of adequate dimensions from renewable resources, the modern trends in this area and the prediction of future progress. The two most proper types of the energy accumulation are chosen by the following process with regarding to the optimal resolution of the given questions. The general balance will be ana-lysed by the comparison of their basic parameters. The other point of this pursuit is to try to realize a small model of the accumulation through the hydrogen´s cycle, it comes to that we can develop the efficiency and influence by the help of the electrolyzer and the metalhydride reservoir is realized energy of accumulation . In the conclusion of this pursuit is the appreciation of the whole project with the view of partly economical and especially with the view of the prospective usage into the electric grid

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Bernroider, Edward, e Nelson K. H. Tang. "A Preliminary Empirical Study of the Diffusion of ERP Systems in Austrian and British SMEs". Institut für Informationsverarbeitung und Informationswirtschaft, WU Vienna University of Economics and Business, 2003. http://epub.wu.ac.at/954/1/document.pdf.

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This paper presents the work in progress regarding an international research project based on an empirical survey. It focuses on the early stages of making the adoption decision, thereafter evaluating and selecting an Enterprise Resource Planning (ERP) system prior to implementation in Small to Medium sized Enterprises (SMEs). The project seeks to close some of the identified gaps in ERP research. In addition, it attempts to link the results of the early stages of decision making to implementation, usage and evolution success in order to allow important conclusions to be made, for example, on the best practices in decision making or decision quality and success. This project will be restricted to the case of ERP software but will also give insights into the potential of integrating ERP and other important applications such as Customer Relationship Management (CRM) or Supply Chain Management (SCM). The proposed research seeks to identify any differences and similarities contributing to the analysed research areas between British and Austrian companies. The choice of companies originating from two different regions in Europe is an important precondition in order to formulate results that will be applicable to the European Union in general. Due to the pervasive nature of ERP systems, our research results should be of interest to a wide range of professional and scholarly communities (from software engineering to accounting), in addition to the Information Systems (IS) field. The results presented should especially help practitioners in SMEs facing the important task of introducing an ERP system into their company. (author's abstract)
Series: Working Papers on Information Systems, Information Business and Operations

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Sobyanina, Elena, e Ilona Mockutė. "ERP post-implementation: risk assessment". Thesis, Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-12844.

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The purpose of this Thesis was to create a framework of 11 risk factors, investigate which of them are the most critical for the company and to find relationships between them Research questions What continuing risks will the company experience after ERP implementation? What relationships and measures can be constructed to better understand and manage risk factors of post-implementation? Some years ago ERP was a novelty in doing business, but nowadays companies have advanced from the implementation to the exploitation phase. Discussions about ERP post-implementation have just started to appear and many researchers see it as a second wave of ERP research. Undesirable risks in post-implementation stage of ERP can affect not just ERP area, they can lead to a total business failure. ERP post-implementation is a very important topic that requires attention, because understanding potential risk factors and their dependence on each other can facilitate managing process and help to avoid negative consequences. Knowledge of the risks can help to bring forth better practices that are consistent with a company’s internal context.

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Strachota, Marek. "Technologické a funkční inovativní trendy ERP". Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-193056.

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Current trends in ERP system were studied by conducting research and analyzes to see to what degree are current ERP trends reflected in existing ERP solutions that are being developed by both Czech and multinational vendors. For the purposes of the research a set of hypotheses was formulated and used to analyze the selected solutions. The research found two trends that are represented in the majority of selected ERP solutions. The application of cloud computing technology and the suitability to use particular solutions as two-tiered ERP. It was also found that all researched vendors to a certain degree implement the principles of Green ICT, although no vendor specifically labeled their software as Green ERP. It was also found that the term Social ERP doesn't appear to be an acceptable term for ERP vendors, although Social ERP functionality of some degree was found to be present in ERP solutions from multinational vendors.

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Eggert, Sandy, e Tanja Eisbrenner. "Aktueller Marktüberblick zum Funktionsumfang von ERP-Systemen". Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2010/4444/.

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In diesem Beitrag lesen Sie: • welche Module die ERP-Lösungen aufweisen, • wie viele Projekte im Jahre 2007 durchgeführt wurden, • welches Alleinstellungsmerkmal die Systeme aus Sicht der Anbieter aufweisen.

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Jensen, William, e Strand Linnea. "“Det här var det bästa systemet de någonsin sett oss bygga” : Organisatoriskt meningsskapande som nyckel till framgångsrika ERP-implementationer". Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446413.

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Denna studie utforskar hur organisationer kan undvika tillkortakommanden vid ERP- implementationer. Studien bygger på två forskningsfrågor: i) “Hur arbetar projektledare med meningsgivande handlingar vid ERP-implementationer?” samt ii) “Vilka faktorer upplevs vara viktiga för systemanvändares meningsskapandet?”. För att besvara frågorna undersöker studien ERP-implementationer utifrån en socialkonstruktivistisk lins där teorin om meningsskapande appliceras. Studien bygger på en kvalitativ metod där 16 projektledare och systemanvändare inom åtta svenska organisationer intervjuats. Resultaten tyder på att projektledare använder fyra kommunikationskanaler i sitt meningsgivande: i) intranät/mail, ii) möten, iii) utbildningar samt iv) superanvändare. Vidare indikerar de även att de kanaler som möjliggjort social interaktion bidraget till en mer positiv uppfattning hos systemanvändarna. Systemanvändarnas meningsskapande upplevs påverkas av fem faktorer: i) generationstillhörighet, ii) förändringsförståelse, iii) avstånd till förändringen, iv) engagemang samt v) förändringskultur. Studien adderar till tidigare forskning genom att fördjupa kunskapen om hur ett socialkonstruktivistiskt synsätt kan användas för att studera ERP-implementationer.
This study explores how organizations can mitigate ERP failures. The study is based on two research questions: i) “How do project managers apply sensegiving during ERP implementations?”, and ii) “What aspects are perceived as important in the sensemaking process amongst systems users?”. Pursuing these questions, the study examines ERP implementations through a social constructivist lens and the theory of sensemaking. The study is based on a qualitative method, in which 16 project managers and system users, among eight Swedish organizations, are interviewed. The findings suggest that project managers use four channels of communication in their sensegiving: i) intranet/mail, ii) meetings, iii) education, and iv) superusers. It is also found that channels that enable social interaction contributes to more positive attitudes amongst system users. The sensemaking amongst system users is perceived to be affected by five aspects: i) generational affiliation, ii) understanding of change, iii) distance to change, iv) commitment, and v) change culture. The study adds to previous research by deepening the knowledge of how a social constructivist approach can be used to study ERP implementations.

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Fonsêca, Gleison Lopes. "Um estudo multicaso sobre as formas de avaliação e mensuração do valor proporcionado pelos sistemas ERP". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/96/96132/tde-08102014-110310/.

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A necessidade de gestão eficiente de recursos e informações criou nas empresas a demanda por investimentos cada vez maiores em tecnologia da informação e comunicação, buscando alcançarem vantagens competitivas sobre seus concorrentes de mercado. Nesse contexto surgiram os sistemas ERP (Enterprise Resource Planning - Sistemas Integrados de Gestão), caracterizados por oferecerem diversas funcionalidades capazes de dar suporte às operações do dia-a-dia das empresas e suas tomadas de decisão. Juntamente com os benefícios advindos desses sistemas, foram necessários elevados investimentos, tanto de tempo e dinheiro, como de recursos internos da empresa. Devido à esses contrapontos, alguns estudos procuraram discutir os benefícios gerados pela adoção dos sistemas ERP em relação aos custos envolvidos no seu processo de implantação. Tais estudos aplicaram diferentes formas de valor agregado por esses sistemas às empresas, encontrando também diferentes resultados. Nesse sentido, com o crescimento da importância dos sistemas ERP para as organizações e a cobrança, cada vez maior, por justificarem os investimentos feitos em projetos de implantação de um sistema ERP, faz-se necessário entender como as empresas avaliam o valor que esses sistemas lhes proporcionam. Para tanto, realizou-se um estudo de caráter descritivo e exploratório, por meio do estudo múltiplo de casos com duas empresas, buscando identificar como avaliam o valor proporcionado pelo sistema ERP. Foram encontrados durante a análise dos resultados diversos dos benefícios já relatados na literatura, apesar de não se ter identificado em nenhuma das empresas um processo formal de avaliação dos mesmos. Muitos dos benefícios identificados não puderam ser atribuídos aos sistemas ERP devido à falta de um processo de avaliação do valor desses sistemas, visto que as empresas não procuraram avaliar a situação anterior e posterior a implantação do mesmo. Em complemento, constatou-se que as empresas não identificam corretamente o valor entregue pelo sistema ERP. A partir dos resultados, conclui-se que a avaliação do valor dos sistemas ERP é um processo complexo, que exige da empresa um planejamento prévio para que possa identificar os benefícios e vantagens que espera obter do sistema, seu escopo de atuação e, que possa avaliar antes da decisão de adoção a adequação do sistema ERP à empresa e vice-versa. Em determinados casos, a subestimação do valor dos sistemas ERP ou a sua avaliação de maneira apenas informal, sem indicadores de desempenho pré-definidos, impede que a empresa realize todo o valor potencial do sistema.
The need of an efficient management of resources and information created in the companies the demand each time larger in information technology and communication searching to achieve competitive advantages over to its market competitors. On this context emerged the Enterprise Resource Planning (ERP) systems, characterized for offer many features capable to give support to day-to-day companies operations and its decisions making. Along with the benefits provided from this systems were needed a high level of investment, both time and money as well as company intern resources. Due to this counterpoints some studies look to discuss the benefits generated for the ERP systems adoption in relation to the involved costs on its implementation process. These studies apply different evaluation forms for these systems to the enterprise finding also different results. On this way, with the grown of ERP systems importance to the organizations and the collection each time bigger to justify the investments made in projects and implementation of an ERP system, became necessary understand how the companies evaluate the value provided for this systems. For this, was realized a descriptive and exploratory study through multiple case study with two enterprises searching to identify how evaluate the value generated for the ERP system. It was found, during the result analysis, many benefits already related in the bibliography despise not identified in none company a formal process to evaluate these. Many of the identified benefits couldn´t be attributed to the ERP systems due to the lack of evaluate process of generated value once that companies doesn´t look to evaluate the before and after implementation moment situation. From the results, concludes that measure and evaluation of ERP system value is a complex process which demands from the company an previous planning which can be identified the benefits and advantages expected to obtain from the system, its acting focus and to evaluate before the adoption decision the adequacy of the system to the enterprise and contrariwise. In some cases the underestimated of ERP systems value or its only informal evaluate way, without performance indicators predefined, prevents the company to realize all its potential value from the system.

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Gregůrek, Tadeáš. "Proces výběru a implementace ERP systému distribuční firmy". Master's thesis, Vysoká škola ekonomická v Praze, 2016. http://www.nusl.cz/ntk/nusl-205529.

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This thesis deals with the choice of ERP system from the perspective of companies engaged in the distribution of lighting signs. The theoretical part covers the concepts of ERP systems, current trends in ERP systems, different versions of these systems and the risks that may arise in this process. The practical part is focused on describing the distribution company, current ERP system that the company uses and the parameters that existing and new system have to comply. The primary aim of this thesis is to evaluate current ERP system offer on the market and to recommend the best suitable system for Dencop Lighting through decision matrix. For this part, methodology of analysis is used. The secondary aim is to asses risks that may arise in the process of changing ERP system.

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Eggert, Sandy. "ERP-Architekturen". Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4448/.

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Gallardo, Fuentes Luis, Andrades Cristián González e Sáez Fernando Tapia. "Sistemas ERP". Tesis, Universidad de Chile, 2003. http://repositorio.uchile.cl/handle/2250/108192.

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El, Sabeh Rana. "Pleiotropism of MyD88, as Determined by its Multiple Protein-Protein Interactions". Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10168.

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MyD88 est une protéine adaptatrice clé dans la signalisation des TLRs/IL-1R qui mène à l'activation de NF-KB et des MAPK, et à la production de cytokines inflammatoires. MyD88 participe à la tumorigénèse par le biais de son activité inflammatoire dans la signalisation des TLRs/IL-1R, et également via son interaction directe avec la kinase Erk dans la cellule cancéreuse. Dans cette thèse, nous identifions de nouveaux partenaires protéiques de MyD88 et nous examinons comment leurs interactions peuvent réguler sa fonction. Nous démontrons que MyD88 interagit avec Ubc9, ce qui conduit à sa sumoylation, et que cette modification posttraductionnelle régule négativement l'inflammation dépendante de MyD88. Nos résultats montrent également que MyD88 interagit avec le récepteur nucléaire, ER-α, et que cette interaction est nécessaire pour la réponse inflammatoire. Enfin, nous avons étudié l'importance de l'interaction MyD88/Erk dans le maintien de la transformation des tumeurs dépendant de l'oncogène Ras. Ces résultats pourraient éventuellement être exploités pour cibler MyD88 et ses interactions dans le traitement des maladies inflammatoires et le cancer
MyD88 is a protein that is at the interface between inflammation and cancer. It is the key adaptor protein used by TLRs/IL-1R to mediate their downstream signaling, resulting in NF-κB and MAPK activation, and inflammatory cytokine production. MyD88 also plays a role in tumorigenesis via two mechanisms, an inflammatory one dependent on its function in TLRs/IL- 1R signaling, and an intrinsic, cell-autonomous mechanism mediated by its interaction with the kinase Erk. Based on the different roles played by MyD88, this thesis work consisted in studying how MyD88 protein-protein interactions can regulate its function. We show that MyD88 interacts with Ubc9, resulting in its sumoylation and subsequent negative regulation of MyD88- mediated inflammation. We also demonstrate that MyD88 interacts with the nuclear receptor ER-α, an interaction necessary for the inflammatory response. Finally, we have studied the importance of the MyD88/Erk interaction in the maintenance of the transformed phenotype of Ras-dependent tumors. These findings could eventually be exploited to target MyD88 and its interactions in the treatment of inflammatory disorders and cancer

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Alouah, Amine, e Eric Smith. "The Influence of ERP Simulations on ERP Systems Implementation". Thesis, Jönköping University, JIBS, Business Informatics, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-13319.

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Companies are always trying to enhance their functioning to achieve a competitive advantage in a given market. Some of the tools that are used to improve organizational functioning include ERP systems. In fact, ERP systems are becoming very popular among firms, to the point where they are considered by some as an ailing business savior. Nevertheless, despite the attractive functions that an ERP system may display to an interested company, implementing such a system successfully is a task that is far from being easy. Several problems may arise in the implementation phase, and a failure to address them correctly can have terrible consequences on the general functioning of a firm. Two of the main factors that contribute to a failed ERP system implementation are training and resistance to change. A tool that may actually help with the ERP system implementation failure is ERP simulation.

The main purpose of this thesis is to study the potential effect that ERP simulations can have on a potential ERP system user skills and knowledge, and thereafter find the potential impact that they may have while being used during an ERP implementation to facilitate training and reduce resistance to change.

The tools that were used to successfully accomplish this research were a personal interview with an ERP simulation expert, a detailed survey with ERP simulation participants, and various information that were collected from books, articles, reports and websites.

This thesis main results show that ERP simulations can enable ERP users to improve their knowledge of ERP systems effectively, and also have potential to contribute during the implementation phase by reducing the possible problems that may arise from the training and the resistance to change perspectives.

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Chahrour, Ghada. "Estrogen-related receptor [alpha] (ERR[alpha]), estrogen receptor [alpha] (ERA[alpha]) and erbB-E (Neu) crosstalk in a mouse model of human breast cancer". Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80237.

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Estrogen (17-beta estradiol) and its receptor (ERalpha) have important physiological roles and are well implicated in human breast cancer, but less is known about the function of estrogen-related orphan nuclear receptor alpha (ERRalpha). The close kinship between ERalpha and ERRalpha and the existing, but yet to be fully characterized, interplay between ERalpha and erbB2 (Neu) protooncogene signaling pathways, suggest that ERRalpha may also play a significant role in breast cancer. Thus, the focus of the current study was to determine the extent of ERRalpha cross talk with ERalpha, its physiological role, as well as its possible implication in erbB2-driven mammary tumorigenesis. Using a well characterized erbB2 mouse model of human breast cancer where tumorigenesis occurs following a long latency period, we generated ERRalpha deficient mice (ERRalphaKO) expressing an activated erbB2 oncogene.

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Laouafa, Sofien. "Rôle protecteur de l'estradiol contre les conséquences systémiques et cellulaires dans un modèle d'apnées obstructives du sommeil : implication des récepteurs nucléaires ERa et ERB". Doctoral thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/34489.

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"Thèse en cotutelle, Université Laval, Québec, Philosophiæ doctor (Ph. D.), Canada et Université Claude Bernard Lyon 1 Villeurbanne, France."
L’apnée du sommeil (AS) induit des variations constantes d'oxygénation artérielle (hypoxie intermittente – HI) qui affectent environ 5 à 7 % de la population. Il se produit une augmentation du stress oxydatif (production d’espèces réactives de l’oxygène - ROS), augmentant les risques cardiovasculaires, neurologiques et métaboliques. Les études épidémiologiques démontrent que la prévalence d'AS est inférieure chez les femmes que chez les hommes, mais après la ménopause la prévalence augmente pour atteindre le même niveau que chez les hommes. L'oestradiol (E2) est un puissant agent antioxydant, mais son rôle éventuel dans le traitement ou la prévention de l'AS n'est pas exploité. Toutefois, l’oestradiol (associé ou non à la progestérone) permet de réduire l'AS chez les femmes ménopausées. Les ROS peuvent être produites par les mitochondries, la NADPH oxydase et/ou la Xanthine oxydase. La mitochondrie est le plus important producteur de ROS (90% de l'oxygène consommé) et son dysfonctionnement est très préjudiciable. L’oestradiol est une cible de la mitochondrie à travers ses récepteurs nucléaires alpha et bêta (ERa et ERβ) qui sont capables de moduler le fonctionnement de la mitochondrie et diminuer la production de ROS. Nous avons testé l’hypothèse dans un modèle animal ovariectomisé exposé à une HI, que l’estradiol et ses agonistes spécifiques ERa et Erβ sont capables de limiter le stress oxydatif cérébral, la dysfonction mitochondriale et l’apparition des désordres systémiques. Nos résultats ont permis de montrer que l’estradiol est capable d’éviter l’augmentation de la pression artérielle et la survenue de désordres respiratoires causés par l’HI. De plus, l’HI augmente le stress oxydatif cérébral en augmentant l’activité d’enzymes pro-oxydantes et en diminuant l’activité d’enzymes antioxydantes. L’estradiol permet de prévenir l’augmentation du stress oxydatif. On retrouve également une dysfonction de la chaine respiratoire mitochondriale dans le cortex en HI qui est préservée de manière différente par le traitement avec les modulateurs sélectifs des récepteurs ERa et ERβ (SERMs). Nous avons montré que ERβ joue un rôle dans le contrôle cardio-respiratoire et la fonction mitochondriale dans le cerveau. Nos résultats apportent une meilleure compréhension du rôle de l’estradiol comme agent protecteur contre l’apnée du sommeil et ses conséquences associées. L’utilisation d’agonistes spécifiques nous renseigne sur le rôle que tient chaque récepteur dans la protection induite par l’estradiol contre la dysfonction mitochondriale. L’utilisation du remplacement hormonal avec de l’estradiol ou des SERMs peut constituer une thérapie efficace contre l’apnée du sommeil et ses conséquences.
Sleep apnea (SA) induces constant changes of arterial oxygenation (Intermittent hypoxia - IH) that affect about 5 to 7% of the general population. IH increases oxidative stress (production of reactive oxygen species – ROS) and lead to cardiovascular, neurological and metabolic risks. Epidemiological studies show that the prevalence of SA is lower in women than in men, but after menopause the prevalence increases to the same level that in men. Estradiol (E2) is a potent antioxidant, but its potential role in the treatment or prevention of SA is not exploited. However, estradiol (with or without progesterone) can reduce SA in postmenopausal women. ROS can be produced by mitochondria, NADPH oxidase and/or Xanthine oxidase. Mitochondria is the most important producer of ROS (90% of oxygen consumed) and its dysfunction is very detrimental. Estradiol is a target of mitochondria through its mitochondria alpha and beta (ERa et ERβ) that are able to modulate mitochondrial function and decrease ROS production. We tested the hypothesis in ovariectomized animal model exposed to IH, that estradiol and its specific receptor ERa and ERβ agonists are able to limit cerebral oxidative stress, mitochondrial dysfunction and the appearance of systemic disorders Our results have shown that estradiol is able to avoid the increase of blood pressure and the occurrence of respiratory disorders caused by IH. Furthermore, IH increases cerebral oxidative stress by increasing activity of pro-oxidant enzymes and decreasing activity of antioxidant enzymes. Estradiol prevents against the increase of oxidative stress. There is also a mitochondrial respiratory chain dysfunction in the cortex by IH, that is preserved differently by treatment with selective ERa and ERβ receptor modulators (SERMs). We have shown that ERβ plays an important role in cardiorespiratory control and mitochondrial function in the brain. Our results provide a better understanding of the role of estradiol as a protective agent against sleep apnea and its associated consequences. The use of specific agonists informs us on the role of each receptors in estradiol-induced protection against mitochondrial dysfunction. The use of hormone replacement with estradiol or SERMs may be an effective therapy against sleep apnea and its consequences.

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Iqbal, Ilyas. "Development of a Generic Integration Layerfor an ERP system". Thesis, Linköpings universitet, Institutionen för datavetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-88555.

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Enterprise Resource Management (ERP) software is used by organizations to control accounting, manufacturing and customer processes. It is common practice that organizations use more than a singular ERP system and various modules from multiple ERP vendors in their business. Hence, there is a need to integrate systems and find technical solutions that allow the EPRs to communicate. This thesis presents the development of a Generic Integration Layer (GIL) that allows various available ERP systems to exchange data. The goal was to design and develop a module that could integrate different ERP modules, fill the data communication gaps among them, with the goal to minimize the need to use several commercial product for data integration purposes. The developed GIL allows flexible import from different file formats as well as provides verification and updates in a database management server. Moreover, it transforms data into a generic format based on XML that can be read by many modern ERPs.
Master Thesis
Development of a Generic Integration Layer for an ERP system

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Mach, Jan. "ERP jako služba". Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-124765.

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This work is focused on the problematics of ERP as a Service and its main goal is to identify opportunities for new Czech providers of ERP as a Service. In theoretical part of this work at first is described that, what is provided by ERP as a Service. Further off is this part focused on that, how and under which terms can be and should be ERP as a Service provided. In last chapter of this part are presented world IT trends (for example Lean IT) and its relation to ERP as a Service. In second part of this work was documented the analysis of selected providers of ERP as a Service. That analysis helped to identify opportunities for new providers of ERP as a Service and also determine advices for new or selected providers of ERP as a Service. Creation of the method of the analysis was based on ideal of the provider of ERP as a Service and its product, which is described in first part of this work. In the analysis was also found some characteristics of Czech market of ERP as a Service and its providers. Benefits of this work are not only pointed at providers of ERP as a Service, but also at its potential customers. They can for example find out in this work on what they should focus on or what they should beware of when choosing ERP as a Service.

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Leonavičius, Arnoldas. "ERP sistemoms diegti taikomų modelių analizė". Master's thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080716_105127-34540.

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Šiame darbe bus išanalizuoti pagrindiniai verslo valdymo sistemų diegimo modeliai ir apibendrintos jų charakteristikos. Darbo tikslas - apibendrinti esamus verslo valdymo sistemų diegimo modelius, tam kad jų diegimas taptų paprastesnis ir būtų sumažinta nesėkmingo adaptavimo rizika. Taip pat reikalinga pasiūlyti verslo valdymo sistemų diegimo metodiką, kurią būtų galima pritaikyti diegiant tokias sistemas. Diegiant ERP sistemas dažnai susiduriama su įvairiomis diegimo problemomis ir sunkumais. Pagrindinė jų - neteisingas sistemos integravimas ir adaptavimas prie konkretaus vartotojo poreikių, todėl reikalinga metodika padedanti šį procesą įvykdyti sklandžiai ir nepriekaištingai.
In this job the methods of Enterprise Resource Planning implementation and problems associated with a particular case of their adjustment are analyzed. The characteristics of these methods are summarized here. The most usable methods of Enterprise Resource Panning implementation are described here. The purpose of this job is to offer the optimum implementation method of Enterprise Resource Planning systems. Also it is necessary to generalize the main existing ERP implementation methods thereto its installation will be simpler and unfortunate adaptation risk will be reducing to the minimum.

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Calhoun, McKenzie L., L. Brian Cross e Rhonda M. Cooper-Dehoff. "Clinical Utility of Beta-Blockers for Primary and Secondary Prevention of Coronary Artery Disease". Digital Commons @ East Tennessee State University, 2013. https://doi.org/10.1586/erc.13.16.

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Evaluation of: Bangalore S, Steg PG, Deedwania P et al. β-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA 308(13), 1340–1349 (2012). The number of myocardial infarctions (MIs) in population remains high and this event is a significant predictor of mortality. Information in the literature points to a reduction in mortality, reinfarction and sudden death in first year, especially in patients with high risk, if β-blockers (BBs) are used after MI. In a perspective study, Zuckerman et al. have determined outcome following pharmacotherapy after acute MI in older adults. It is apparent that a number of matters require consideration in evaluation of the effectiveness of BBs. It seems that not all patients benefit equally from treatment with BBs but such an intervention reduces mortality. It is also important to recognize that the beneficial effects of BBs should not be considered in isolation since the biological system is too complex to manipulate with the use of a single class of drugs.

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Sofija, Bekić. "Razvoj bioloških testova za identifikaciju liganada steroidnih receptora i ispitivanje aktivnosti steroidogenog enzima aromataze". Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2020. https://www.cris.uns.ac.rs/record.jsf?recordId=114417&source=NDLTD&language=en.

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U ovoj doktorskoj disertaciji razvijen je fluorescentni test u kvascu za identifikaciju potencijalnih prirodnih ili sintetičkih liganada ERα, ERβ ili AR i kvantifikaciju njihovog afiniteta vezivanja sa mogućnošću testiranja čitavih biblioteka modifikovanih steroida i ksenoestrogena. Takođe, opisana je primena optimizovanog biosenzora za procenu estrogenog potencijala sintetskih steroida i odabranih biljnih ekstrakata bogatih jedinjenjima fitoestrogenih osobina. U cilju potpunijeg sagledavanja mehanizma delovanja odabranih modifikovanih steroida ispitana je njihova antiproliferativna aktivnost prema ćelijskim linijama estrogen receptor pozitivnog kancera dojke (MCF-7) i kancera prostate (PC-3), dok su in silico metodom molekularnog dokinga predviđene energije i geometrije vezivanja ovih jedinjenja za ligand-vezujuće domene ERα i ERβ. Drugi deo ovog rada obuhvata razvoj testa za ispitivanje aktivnosti humanog enzima aromataze, heterologno eksprimiranog u ćelijama kvasca Saccharomyces cerevisiae i/ili bakterija Escherichia coli, u prisustvu ili odsustvu inhibitora. Interakcije modifikovanih steroida, odabranih na osnovu strukture, sa aromatazom ispitane su osetljivim spektroskopskim metodama, praćenjem promene spinskog stanja Fe iz hem grupe ili promene fluorescencije ostatka triptofana iz aktivnog centra usled konformacione promene proteina, izazvane interakcijom sa ligandom. Razvijeni in vitro testovi bez upotrebe radioaktivnih izotopa su, osim visoke efikasnosti i bezbednosti po korisnika i okolinu, pokazali specifičnost i ekonomičnost u preliminarnom skriningu liganada steroidnih receptora i inhibitora aromataze. Jedinjenja kod kojih je detektovana značajna biološka aktivnost mogu potencijalno poslužiti kao osnova za razvoj terapeutika u lečenju hormon-zavisnih bolesti i stanja, koja danas predstavljaju globalni zdravstveni problem.
In this doctoral dissertation, a fluorescent assay in yeast was developed for identification of potential natural or synthetic ligands of ERα, ERβ or AR andquantification of their binding affinity, as well asevaluation of the estrogenic potential of synthetic steroids and selected plant extracts rich in phytoestrogen content. The assay could be used to screen libraries of modified steroids and xenoestrogens. In order to better understand the biomedical potential of selected modified steroids, results were compared to antiproliferative activity against estrogen receptor positive breast cancer (MCF-7) and prostate cancer (PC-3) cell lines. Binding energies and the geometry of binding of these compounds for ERα and ERβ ligand binding domains were predicted in silico by molecular docking methods. The second part of this study includes development of an assay for study of aromatase activity in the presence or absence of inhibitors by heterologous expression of human aromatase in Saccharomyces cerevisiae and/or Escherichia coli cells, as model-organisms. Furthermore, interactions between modified steroids, selected according to their structure, and aromatase were tested using sensitive spectroscopic methods based on ligand-induced changes in the spin state of Fe from the heme group or changes in the fluorescence of a tryptophan residue in the active site. The non-radioactive in vitro assays developed here, besides high efficiency, user and environmental safety, also have greater specificity and are more cost-effective for preliminary screening of steroid receptor ligands and aromatase inhibitors. Additionally, compounds identified to express significant biological activity can serve as a basis for the development of potential therapeutics in the treatment of hormone-dependent diseases and conditions, a global health issue today.

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38

Vašek, Martin. "Využití databázových systémů v sw balících typu ERP/ERP II". Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-76036.

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This thesis is concerning with problems of using database systems in ERP / ERP II software packages. The goal is to define position of ERP / ERP II systems in the Information System market. With this topic are also connected characteristics of database systems and definition of their specific position towards ERP / ERP II solutions. Except classical solutions, when the whole Information System is situated "inside" a company, there are also analyzed new attitudes, which respect external provider of ERP / ERP II and database services, particularly SaaS and Cloud Computing technology. This thesis also deals with evaluation of contributions and threats of these new business models, respecting different size of ERP / ERP II solutions. After introductory theoretical chapters, we choose respondents from groups of producers and distributors of ERP / ERP II products and we implemented a survey through questionnaire research. The goal is to clarify main reasons of choice of specific database platforms, used with different types of ERP / ERP II solutions. Afterward, with the aid of defined hypothesis, I'm trying to explain a degree of platform independence of robust ERP / ERP II software packages, towards database platforms. In closing parts of the thesis, there are compared individual database platforms among each other, respecting their suitability of usage in ERP / ERP II systems. Database systems are closely analyzed from several points of view. On the basis of ascertained theoretical and empirical frequency of particular database solutions we determine dominant market players and with the aid of multicriterial comparison we clear up reasons of their success among other competitors. Finally, we outline an anticipated trend, where the database systems market destined for ERP / ERP II products should grow in.

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Files, Benjamin Kym. "The nuclear era /". Cover title, title page, contents and introduction only, 2003. http://web4.library.adelaide.edu.au/theses/09AR/09arf481.pdf.

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40

Ewbank, Antônio Gabriel Gonçalves. "Antes como Era". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/27/27159/tde-11092018-112105/.

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41

Ortiz, de Zevallos Felipe. "La era global". THĒMIS-Revista de Derecho, 2015. http://repositorio.pucp.edu.pe/index/handle/123456789/108853.

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42

Pála, Milan. "Reporting - ERP systém". Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2013. http://www.nusl.cz/ntk/nusl-236395.

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This work deals with creating a module for existing ERP system. Module should be able to produce dataprogress of production, monitor productivity of production and warn if some issue will happen. This work evaluates a processing of a large amount of data and it shows different possibilities how to precalculate data. It also deals with a draft how to predict information from known data.

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43

Lega, Lukáš. "Implementace ERP systému". Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-256620.

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Enterprise Resource Planning (ERP) was developed from the fifties of the last century. Mainly used was for accounting. Another milestone was seventies when there was added functionality of material management. The biggest extensions came in the nineties when there was a significant increase of servers performance and ERP systems could be more complex. Suppliers began to develop new modules for Customer Relationship Management (CRM), analytics named Business Intelligence (BI), Warehouse Management System (WMS) and others. Expansion of Internet and secure connections began also cause of develop the Electronic Data Interchange (EDI). ERP systems are more complex so implementation of this systems are more complex too because it extends to most processes in the company. Implementation starts by selecting an ERP system in relation to the processes maps of the company. Then it is necessary to manage whole process of the implementation and write target concepts of each parts. Equally important is the data preparation and cleaning of data base for migrate to a new ERP system. After programming, editing and parameterization of the required functions and processes following phase of testing. If all goes as expected and acceptance document is approved, ERP system is prepared to productive mode.

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44

Týn, Jan. "Implementace ERP systému". Master's thesis, Česká zemědělská univerzita v Praze, 2017. http://www.nusl.cz/ntk/nusl-256821.

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This thesis deals with the implementation of the ERP system. The thesis is divided into theoretical knowledge and case study. Its aim is to develop a comprehensive search for applications such as ERP and its application to a specific case study. The theoretical part describes the characteristics and evolution of ERP systems. The practical part deals with a case study of the implementation of the specific ERP system.

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45

Rodríguez, León Karla Melissa. "Análisis de las bases de datos distribuidas como una alternativa para los sistemas ERP en las empresas". Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2013. http://hdl.handle.net/20.500.11799/99983.

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Las empresas actualmente trabajan con sistemas de información para agilizar sus procesos, tales como los sistemas de información gerencial, de apoyo a las decisiones, los sistemas ERP, entre otros. En este caso la investigación se enfoca en los sistemas de planificación de recursos empresariales (ERP), que son sistemas que integran y manejan los procesos de negocios (manera de coordinar y organizar actividades para elaborar un producto) que hay en las áreas funcionales de una organización; estos sistemas les proporcionan a las empresas mejor comunicación entre sus departamentos y mayor fiabilidad en la información por lo cual son de gran importancia para las organizaciones, ya que además esto hace que la productividad de la organización aumente significativamente.

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46

Holm, Frida, e Eric Isaksson. "Implementering av ERP-system i offentlig sektor : Kritiska faktorer och mått att beakta för framgång". Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169310.

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ERP-system (Enterprise Resource Planning Systems) spelar en allt större roll för organisationer och att implementeringen av dem blir framgångsrika är av stor betydelse för ett företag. Det finns exempel där en misslyckad implementeringsprocess medfört att hela företag försatts i konkurs. Följaktligen har flera studier gjorts gällande ERP-implementeringar. Ibland syftar artiklarna till att visa på rekommenderade tillvägagångssätt genom att redogöra för implementeringens kritiska framgångsfaktorer – de moment, aktiviteter eller liknande som genom studien identifierats som avgörande för en framgångsrik implementering. Majoriteten av studierna har berört organisationer i privat sektor. Författarna till denna uppsats ansåg att det fanns starka argument för att dessa studiers resultat inte med nödvändighet är applicerbara på organisationer i offentlig sektor, utan att de kritiska framgångsfaktorerna kan skilja sig åt eller ha olika prioriteringsgrad i respektive sektor. Att studera huruvida kritiska framgångsfaktorer och framgångsmått kan skiljas åt och prioriteras olika torde vara av vikt för implementeringar av ERP-system. Denna uppsats är uppstånden av denna anledning, att söka finna kritiska faktorer i implementeringen av ERP-system för organisationer i offentlig sektor.

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47

Pololáník, Pavel. "Analýza současných statistických výkazů a SW možností pro hodnocení energetických soustav". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442544.

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Diploma thesis deals with the issue of statistical reporting Energy regulátory office ČR. The introduction describes the contents regularly published reports on the operation of the electricity system in the Czech Republic. In the thsis deals with the analysis of statistical reports. Processing code in Python and describes its implementation in analytical platform KNIME.

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48

Vagner, Vlastimil. "Transformace konceptuálních modelů do realizace informačního systému". Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-72513.

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This thesis deals with the linkages between data models from conceptual models to physical design of information bases, used for implementation. The aim is to analyze the modern approach to design systems and specify how detailed the conceptual modeling and impact on the quality of the final form of application or system, including processes that take place in advance to the next level of design. Approximated the techniques the transition between these levels and will take into account structural features and limitations of selected platforms and requirements for their design and mutual coherence level view of the system. For the purpose of the thesis the well known data modeling methods are being analyzed together with their applicabilities.

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49

Gomis, Marie-Joseph. "Web-based ERP systems: the new generation : case study: mySAP ERP". Thesis, Jönköping University, JTH, Computer and Electrical Engineering, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-7711.

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With the proliferation of Internet, ERP systems like all the domains of Information Technology have known an important evolution. This final thesis project is a study about the evolution of ERP systems, more precisely about their migration to the Web giving birth to a new generation of systems: the Web-Based or Web-enabled ERP systems. This migration to the Web is justified by the difficulty of making possible the communication between partner’s legacy systems and the organizations’ ERP systems. A historical evolution of these systems is presented in order to understand the reasons that lead vendors to adopt the Web Service Technology. Based on different studies, the main technologies such as Web services, Service-Oriented Architecture and Web Application server are also presented. From an interpretative research approach mySAP ERP has been chosen as a case study. This Master’s thesis has been led into AIRBUS France Company within the framework of the SAP Customer Competence Center (SAPCCC) Web site project. The project is aimed at re-building the SAPCCC Web site. The new characteristic of the Web site is to make it accessible by all AIRBUS partners working with SAP applications. To make the Web site accessible by the partners from their own applications located on their own platforms the development has been done thanks to mySAP ERP which is an ERP using the Web service technology. Finally, this thesis presents a comparative study between traditional ERP systems and the new generation of Web-based ERP systems.

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Rashidzadeh, Azar Soran, e Muhammad Irfan Chaudhry. "ERP implementation - Seeing through a lens : A comparative literature review regarding the factors that influence a successful ERP system implementation". Thesis, Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-10074.

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Purpose: The purpose of this thesis is to describe and analyse the factors that contribute to the successful ERP system implementation, the stakeholders of ERP system and how these stakeholders are related to CSFs of ERP system implementation. Design/ methodology/ approach: The research methodology approach chosen for this research is based on reality and clear research which includes qualitative and quantitative method for collecting and analysing data. Data for this research consists of secondary data, gathered by conducting a critical literature review of research papers published by journals, magazines and books. The content analysis and comparative study methods are used to analyse data. Findings: Seventeen CSFs that are considered to contribute to ERP implementation success have been identified in accordance with their prioritization where twelve of them have been described; by analyzing some widely accepted in prior researches. Three stakeholders of ERP such as “Top management, IT professionals and End-users” have been identified and their involvement in the ERP implementation has been described. The result revealed that several CSFs of ERP such as “user training and involvement, ERP teamwork and selection of ERP are directly related to End-users”. The findings also revealed that Top management are related to majority of CSFs such as “top management support and commitment, change management, business plan and vision, system quality, project management, effective communication plan, selection of ERP, monitoring and focused performance evaluation, project champion, and business and IT infrastructure”. The result from analysis also showed a correlation between IT professionals and several CSFs such as “selection of ERP, system quality, user training and involvement, post-implementation evaluation, business plan and vision, change management, ERP teamwork, effective communication plan, and business and IT infrastructure”.

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