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Letteratura scientifica selezionata sul tema "Estrogen Therapeutic use"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 31 gennaio 2023

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Articoli di riviste sul tema "Estrogen Therapeutic use"

1

Fillit, Howard. "Future Therapeutic Developments of Estrogen Use." Journal of Clinical Pharmacology 35, no. 9S (September 1995): 25S—28S. http://dx.doi.org/10.1002/j.1552-4604.1995.tb04144.x.

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2

Martin-Jiménez, Cynthia, Diana Milena Gaitán-Vaca, Natalia Areiza, Valentina Echeverria, Ghulam Md Ashraf, Janneth González, Amirhossein Sahebkar, Luis Miguel Garcia-Segura, and George E. Barreto. "Astrocytes Mediate Protective Actions of Estrogenic Compounds after Traumatic Brain Injury." Neuroendocrinology 108, no. 2 (November 4, 2018): 142–60. http://dx.doi.org/10.1159/000495078.

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Traumatic brain injury (TBI) is a serious public health problem. It may result in severe neurological disabilities and in a variety of cellular metabolic alterations for which available therapeutic strategies are limited. In the last decade, the use of estrogenic compounds, which activate protective mechanisms in astrocytes, has been explored as a potential experimental therapeutic approach. Previous works have suggested estradiol (E2) as a neuroprotective hormone that acts in the brain by binding to estrogen receptors (ERs). Several steroidal and nonsteroidal estrogenic compounds can imitate

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3

Santen, Richard J., Risa Kagan, Corrado J. Altomare, Barry Komm, Sebastian Mirkin, and Hugh S. Taylor. "Current and Evolving Approaches to Individualizing Estrogen Receptor-Based Therapy for Menopausal Women." Journal of Clinical Endocrinology & Metabolism 99, no. 3 (March 1, 2014): 733–47. http://dx.doi.org/10.1210/jc.2013-3680.

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Context: Adding progestogens to estrogens changes the risk profile of hormonal therapy for menopausal women, and recent data support the need for progestogen-free options. Several current and evolving approaches to managing estrogen deficiency allow for progestogen omission. We review the mechanisms of estrogen activity and provide an overview of emerging and available estrogen receptor (ER)–based therapies. Evidence Acquisition: PubMed was searched for relevant English-language articles using keywords pertaining to estrogen deficiency, menopause, hormone therapy, and estrogen-only therapy. Pi

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4

Macciò, Antonio, and Clelia Madeddu. "Obesity, Inflammation, and Postmenopausal Breast Cancer: Therapeutic Implications." Scientific World JOURNAL 11 (2011): 2020–36. http://dx.doi.org/10.1100/2011/806787.

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Breast cancer is the female malignant neoplasia with the highest incidence in the industrialized world. Although early diagnosis has contributed to therapeutic success, breast cancer remains a major health issue. In the last few year the hormone therapy for estrogen-dependent breast cancer has evolved achieving significant clinical results; at the same time, it has enabled us to better define the role of estrogens in the etiopathogenesis of this tumour. Weight increase and obesity have been identified as the most important risk and prognostic factors for breast cancer in postmenopausal women.

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Mitra, Saikat, Mashia Subha Lami, Avoy Ghosh, Rajib Das, Trina Ekawati Tallei, Fatimawali, Fahadul Islam, et al. "Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications?" Cancers 14, no. 3 (February 1, 2022): 759. http://dx.doi.org/10.3390/cancers14030759.

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In recent years, hormone therapy has been shown to be a remarkable treatment option for cancer. Hormone treatment for gynecological cancers involves the use of medications that reduce the level of hormones or inhibit their biological activity, thereby stopping or slowing cancer growth. Hormone treatment works by preventing hormones from causing cancer cells to multiply. Aromatase inhibitors, anti-estrogens, progestin, estrogen receptor (ER) antagonists, GnRH agonists, and progestogen are effectively used as therapeutics for vulvar cancer, cervical cancer, vaginal cancer, uterine cancer, and ov

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Gérard, Céline, Mélanie Mestdagt, Ekaterine Tskitishvili, Laudine Communal, Anne Gompel, Elisabete Silva, Jean-François Arnal, et al. "Combined Estrogenic and Antiestrogenic Properties of Estetrol on Breast Cancer may provide a Safe Therapeutic Window for the Treatment of Menopausal Symptoms." Journal of SAFOMS 3, no. 1 (2015): 31–33. http://dx.doi.org/10.5005/jsafoms-3-1-31.

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Abstract Increased risk of breast cancer is a critical side-effect associated with the use of a menopausal hormone therapy (MHT). Estetrol (E4) is a natural estrogen produced by the human fetal liver and is a promising compound for clinical use in MHT. However, its impact on breast cancer is controversial and poorly defined. In this preclinical study, we show that E4 acts as a weak estrogen by stimulating the growth of hormone-dependent breast cancer only at concentrations exceeding menopausal therapeutic needs. Estetrol (E4) presents also an antitumor activity by decreasing the strong prolife

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7

Hwang, Wu Jeong, Tae Young Lee, Nahrie Suk Kim, and Jun Soo Kwon. "The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders." International Journal of Molecular Sciences 22, no. 1 (December 31, 2020): 373. http://dx.doi.org/10.3390/ijms22010373.

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Increasing evidence suggests estrogen and estrogen signaling pathway disturbances across psychiatric disorders. Estrogens are not only crucial in sexual maturation and reproduction but are also highly involved in a wide range of brain functions, such as cognition, memory, neurodevelopment, and neuroplasticity. To add more, the recent findings of its neuroprotective and anti-inflammatory effects have grown interested in investigating its potential therapeutic use to psychiatric disorders. In this review, we analyze the emerging literature on estrogen receptors and psychiatric disorders in cellu

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8

Zhao, Zhuo, Hao Wang, Jewell A. Jessup, Sarah H. Lindsey, Mark C. Chappell, and Leanne Groban. "Role of estrogen in diastolic dysfunction." American Journal of Physiology-Heart and Circulatory Physiology 306, no. 5 (March 1, 2014): H628—H640. http://dx.doi.org/10.1152/ajpheart.00859.2013.

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The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women after menopause and may lead to heart failure. While evidence suggests that estrogens protect the premenopausal heart from hypertension and ventricular remodeling, the specific mechanisms involved remain elusive. Moreover, whether there is a protective role of estrogens against cardiovascular disease, and specifically LVDD, continues to be controversial. Clinical and basic science have implicated activation of the renin-angiotensin-aldosterone system (RAAS), linked to the loss of ovarian estrogens, in th

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Farkas, Szidónia, Adrienn Szabó, Anita Emőke Hegyi, Bibiána Török, Csilla Lea Fazekas, Dávid Ernszt, Tamás Kovács, and Dóra Zelena. "Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions." Biomedicines 10, no. 4 (April 6, 2022): 861. http://dx.doi.org/10.3390/biomedicines10040861.

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Estrogen is one of the most important female sex hormones, and is indispensable for reproduction. However, its role is much wider. Among others, due to its neuroprotective effects, estrogen protects the brain against dementia and complications of traumatic injury. Previously, it was used mainly as a therapeutic option for influencing the menstrual cycle and treating menopausal symptoms. Unfortunately, hormone replacement therapy might be associated with detrimental side effects, such as increased risk of stroke and breast cancer, raising concerns about its safety. Thus, tissue-selective and no

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10

Sulaymanova, R. T. "EXPERIMENTAL MODELS OF TRANSGENERATIONAL EFFECTS OF THE INFLUENCE OF ESTROGENS ON THE MORPHOLOGY OF REPRODUCTIVE ORGANS IN POSTNATAL ONTOGENESIS." Morphological newsletter 27, no. 1 (March 30, 2019): 36–44. http://dx.doi.org/10.20340/mv-mn.19(27).01.36-44.

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In the modern clinical practice there is an increase in the use of hormones, their analogues and substances with hormone-like action in medical practice for the regulation of the menstrual cycle, conception, prevention, maintenance and resolution of pregnancy. According to official reports, in recent years, the number of annual cycles of assisted reproductive technology with hormonal support has increased six times in the country. The purpose of the review is to summarize current data on the effects of experimental and clinical effects of various doses of estrogens and drugs with estrogenic ef

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Tesi sul tema "Estrogen Therapeutic use"

1

Jetson, Rachael Rene. "Design and Development of Potential Therapeutic Agents for Use in Hormone Responsive Cancers." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1384270219.

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Dennis, Maxine Elizabeth. "Oestrogen and atherosclerosis." University of Western Australia. School of Pathology and Laboratory Medicine, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0134.

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[Truncated abstract] Our understanding of the actions of oestrogen on the vasculature has recently been questioned following the results of large clinical trials revealing a negative effect of hormone replacement therapy (HRT) on cardiovascular disease (CVD) risk amongst postmenopausal women. It is important to determine how a hormone with numerous positive effects on intermediate pathways of atherosclerosis fails to offer cardioprotection. Further investigation into the actions of oestrogen in the vasculature may add to our current understanding of the pathogenesis of atherosclerosis and oest

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3

Benz, David James. "Estrogenic and androgenic regulation of human osteoblast-like cells is mediated by specific steroid receptors." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185442.

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The effectiveness of estrogen replacement therapy in the prevention of postmenopausal osteoporosis has led to its current widespread use throughout the United States and much of Western Europe, and recently, clinical correlations between circulating androgen levels and structural bone integrity have been presented. Nevertheless, the biochemical mechanism through which estrogens and androgens act to protect and maintain bone has remained unclear. One possibility is that these hormones directly modulate the activity of cells responsible for bone formation. Therefore, studies were conducted to ex

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Amaral, Sandra Margarida Caldas. "Estrogen receptor dependent genetic and epigenetic factors of tamoxifen resistance." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2009. http://hdl.handle.net/10362/5038.

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Resumo: A decisão da terapêutica hormonal no tratamento do cancro da mama baseiase na determinação do receptor de estrogénio alfa por imunohistoquímica (IHC). Contudo, a presença deste receptor não prediz a resposta em todas as situações, em parte devido a limitações do método IHC. Investigámos se a expressão dos genes ESR1 e ESR2, bem como a metilação dos respectivos promotores, pode estar relacionada com a evolução desfavorável de uma proporção de doentes tratados com tamoxifeno assim como com a perda dos receptores de estrogénio alfa (ERα) e beta (ERß). Amostras de 211 doentes com cancro

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Papich, Sandra G. (Sandra Gene). "Estrogen Replacement Therapy and its Association with Life Satisfaction of Women over Fifty." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc500948/.

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This study analyzed the effects of estrogen replacement therapy (ERT), ethnicity, marital status, education level, maternal status and financial security on the perceived life satisfaction of women over fifty. Information was collected from 125 subjects at an independent school district. The instrument was adapted from a life satisfaction scale originally developed by B. Neugarten. Eight demographic items included ERT use, age, menopause status, marital status, educational level, ethnicity and perception of financial security. Statistical analysis consisting of one way analysis of variance, St

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Hatchell, Esme Claire. "Insight into estrogen action in breast cancer via the study of a novel nuclear receptor corepressor : SLIRP." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0206.

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[Truncated abstract] Breast cancer is the cause of significant suffering and death in our community. It is now estimated that the risk of developing breast cancer for an Australian woman before the age of 85 is 1 in 8, with this risk rising for unknown reasons. While mortality rates from breast cancer are falling due to increased awareness and early detection, few new treatments have been developed from an advanced understanding of the molecular basis of the disease. From decades of scientific research it is clear that estrogen (E2) has a large role to play in breast cancer. However, the basic

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Visser, Jacobus Albertus Koch. "Phytoestrogenic extracts of Cyclopia modulate molecular targets involved in the prevention and treatment of breast cancer." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86718.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Phytoestrogen containing extracts of Cyclopia, an indigenous South African fynbos plant used to prepare honeybush tea, may serve as a source of new estrogen analogues. It would be of great benefit if these new analogues would not only prevent the development and progression of breast cancer which, globally, is responsible for the highest number of cancer associated deaths among females, but also have a reduced side-effect profile when compared to current treatments and, in addition, also alleviate menopause associated symptoms.

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Wu, Wing Man. "An investigation into the neuroprotective effects of estrogen and progesterone in a model of homocysteine-induced neurodegeration." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003284.

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Homocysteine (Hcy) is a sulfur containing amino acid and is a potent neurotoxin. It has been shown that elevated levels of Hcy, termed hyperhomocysteinemia, plays a role in the pathologies of Alzheimer’s disease (AD) and age-related cognitive decline. Hcy is a glutamate agonist, which causes in increase in Ca[superscript (2+)] influx via the activation of NMDA class of excitatory amino acid receptors, which results in neuronal cell death and apoptosis. Estrogen and progesterone are female hormones that are responsible for reproduction and maternal behaviour. However, in the last decade, it is

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9

Kampen, Diane L. "The relationship between estrogen and memory in healthy postmenopausal women and women in the early stages of Alzheimer's disease." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41108.

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The effects of exogenous estrogen administration on aspects of memory and cognition in women were examined in two studies. In Study 1, women receiving estrogen replacement therapy were compared to untreated women on four measures of verbal memory. Those receiving estrogen had significantly better scores on a measure of delayed memory for propositional material. In Study 2, women in the early stages of Alzheimer's Disease (AD) were administered either estrogen or placebo on a double-blind basis for six months. Women given estrogen showed improvement on a measure of verbal memory and spatial att

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Phillips, Susana M. (Susana Maria). "The relationship between sex steroid levels and memory functions in women." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28513.

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Memory function was examined in association with sex hormone levels in women. The results of the first study suggest that self-reports of memory problems were especially prevalent among women attending a menopause clinic compared to a nonpatient sample. In the following investigation, women given placebo after undergoing a bilateral oophorectomy showed decreases in memory performance, specifically on a paired-associate learning task, coincident with declines in estrogen levels. Significant improvements were found in estrogen-treated women pre- to postoperatively in the immediate recall of para

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Libri sul tema "Estrogen Therapeutic use"

1

The estrogen decision: A self-help program. Los Altos, Calif: Westchester Pub. Co., 1994.

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2

R, Bartos James, ed. Estrogens: Production, functions and applications. Hauppauge, NY: Nova Science, 2009.

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Farley, Dixie. How to take your medicine: Estrogens. [Rockville, Md: Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, Office of Public Affairs, 1993.

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Farley, Dixie. Cómo tomar las medicinas: Los estrógenos. [Rockville, Md. (5600 Fishers Lane, Rockville 20857): Departamento de Salud y Servicios Sociales, Servicio de Salud Pública, Administración de Drogas y Alimentos, Oficina de Asuntos Públicos, 1991.

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Farley, Dixie. Cómo tomar las medicinas: Los estrógenos. [Rockville, Md. (5600 Fishers Lane, Rockville 20857): Departamento de Salud y Servicios Sociales, Servicio de Salud Pública, Administración de Drogas y Alimentos, Oficina de Asuntos Públicos, 1991.

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Nachtigall, Lila. Estrogen: Revised and Expanded. New York: HarperPerennial, 1991.

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Henkel, Gretchen. Making the estrogen decision. New York: Fawcett Columbine, 1993.

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Henkel, Gretchen. Making the estrogen decision. Los Angeles: Lowell House, 1992.

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Making the estrogen decision. New York: Fawcett Columbine, 1992.

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Nachtigall, Lila. Estrogen. 2nd ed. New York: HarperPerennial, 1995.

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Capitoli di libri sul tema "Estrogen Therapeutic use"

1

Oettel, M. "Therapeutic Use of Estrogens in Veterinary Medicine." In Handbook of Experimental Pharmacology, 603–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-60107-1_27.

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2

Espino y Sosa, Salvador, Myriam Cortés Fuentes, Jacobo Alejandro Gómez Rico, and Manuel Cortés Bonilla. "Non-polymeric Microspheres for the Therapeutic Use of Estrogens: An Innovative Technology." In Estrogen. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.82553.

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Trombetta, Giulia, Monica Della Martina, Martina Venier, and Angelo Cagnacci. "Hormonal Replacement Therapy After Neoplasia Treatment." In NEOPLASIA and FERTILITY, 175–86. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815050141122010012.

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Post-menopausal hormonal therapy (HT) may help to improve quality of life and prevent long-term consequences of estrogen deficiency. The use of HT in postmenopausal cancer survivors is controversial, particularly for those women having survived hormone-dependent tumors, like breast or gynecological cancers. Endometrial cancer is the most frequent gynecological cancer. The limited data of the literature on women having suffered from endometrial cancer do not show an increased recurrence or death with HT use, but guidelines do not yet indicate the generalized use of HT in these women. HT should be avoided in uterine sarcomas. Breast cancer survivors suffer from climacteric symptoms after menopause or as a consequence of adjuvant hormonal anti-estrogen treatment. The risk of cancer recurrence with HT is uncertain: the two randomized prospective controlled trials were prematurely stopped. Actually, clinical guidelines contraindicate HT use in breast cancer survivors. New therapeutic approach for selected symptoms such as ospemifene (a SERM molecule) can be promising. There is no strong evidence for denying HT to patients treated for ovarian cancer, independently of disease stage. Even for women with an endometrioid carcinoma of the ovary, an estrogen-sensitive tumor, evidence indicates no harm from HT. More controversial is the use of HT after granulosa cell tumors. HT can be administered in women treated for squamous cancers of the cervix and the vulva or vaginal neoplasm. The approach to cervical adenocarcinoma should follow that of endometrial cancer. In conclusion, HT is not contraindicated in all women with a history of gynecological cancer, but its use is dependent on the type of cancer the woman has suffered from.

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Fidalgo, Javier, Ana Novo Barros, and Ana Casas. "Resveratrol: Apromising Antiaging Agent for Cosmetic Skin Treatments." In Resveratrol - Recent Advances, Application, and Therapeutic Potential [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.107860.

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Nowadays, resveratrol, a polyphenolic phytoalexin is increasingly included in the formulas of cosmetic products and dermatology as an active ingredient, as a consequence of the well-known health beneficial properties, namely antioxidant, anti-inflammatory, anti-viral and anti-bacterial effects. This important compound can be biosynthesized naturally by plants or by industrial synthetic processes. Apart from its anti-inflammatory and antioxidant effects, a broad spectrum of effects has been attributed to the use of this compound such as anti-aging, skin-whitening, anti-angiogenic, collagen I and III stimulation (in fibroblasts) and estrogen-like effects, as well as the ability to protect cells against hydrogen peroxide-induced oxidative stress and UV-irradiation-mediated cell death. In cosmetology and dermatology has been popular because of its ability to penetrate the skin barrier and its anti-aging activity. In fact, resveratrol as an important impact on the regulation of inflammation and, as consequence, repair-related processes in skin. Furthermore, when administered either topically or orally has been proven to be safe and also to overcome the skin barrier. This review will focus in its potential application on melasma treatment and in photo-aging. Resveratrol chemistry, pharmacology, mechanism of action and evidence of its efficacy as photo skin aging protector and its potential use in melasma is discussed.

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Ramasamy, Kumaraguruparan, Cathy Samayoa, Naveen Krishnegowda, and Rajeshwar R. Tekmal. "Therapeutic Use of Estrogen Receptor β Agonists in Prevention and Treatment of Endocrine Therapy Resistant Breast Cancers: Observations From Preclinical Models." In Progress in Molecular Biology and Translational Science, 177–94. Elsevier, 2017. http://dx.doi.org/10.1016/bs.pmbts.2017.08.002.

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Yousuf, Hanna. "Role of Estrogens in Addiction-Related Learning." In Estrogens and Memory, 456–74. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190645908.003.0027.

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Females exhibit more vulnerability to cocaine abuse compared to males. Sexually dimorphic patterns of cocaine seeking have been observed in both humans and rodents during the different stages of the addiction cycle. While cocaine pharmacokinetics play a minimal role in driving sex differences in addictive behaviors, hormonal influences may be responsible for the reinforcing properties of cocaine in females. In particular, 17β‎-estradiol (E2), enhances performance in a variety of learning paradigms and may act to enhance the formation of drug-related learning. Paradoxically, preclinical work demonstrates that the memory-enhancing effects of E2 may also aid to suppress cocaine seeking via extinction training. In addition to discussing how E2 mediates cocaine use in females, this chapter provides neurobiological mechanisms underlying E2’s influence on cocaine addiction. Finally, this chapter discusses potential strategies for novel therapeutic interventions for female cocaine addicts.

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Hubbard, W. J., and I. H. Chaudry. "The Use of Estrogen for the Treatment of Traumatic Brain Injury." In New Therapeutics for Traumatic Brain Injury, 161–77. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-802686-1.00010-9.

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Goswami, Nandini, Shalini Jain, and Sreemoyee Chatterjee. "Nutritive Importance and Medicinal Properties of Foeniculum vulgare Mill. (Fennel) and Trachyspermum ammi L. (Ajwain)." In Therapeutic Implications of Natural Bioactive Compounds, 135–54. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815080025122030010.

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In tropical and sub-tropical countries, spices have a long history in traditional food preparations. Several spices are described to have medicinal effects. Among them are Foeniculum vulgare Mill. and Trachyspermum ammi L. belonging to the Apiaceae family are the most common spices known for their highly aromatic nature and flavor with culinary and traditional uses. F. vulgare seeds increase urine flow, improve the digestive system, promote menstruation and improve milk flow. Various pharmacological activities of F. vulgare such as antioxidant, hepatoprotective, antimicrobial, estrogenic, acaricidal, antihirutism, antidiabetic, anti-inflammatory, and antithrombotic, have been reported in the literature. T. ammi seeds are used for relieving flatulence, dyspepsia, spasmodic disorders, common cold, acute pharyngitis, sore and congested throat, dipsomania, and hysteria. T. ammi seeds are reported to possess antimicrobial, antioxidant, hepatoprotective, nematicidal, antihelmintic, and gastroprotective activities. The review presents an overview of the traditional uses, phytochemical constituents, and pharmacological properties of F. vulgare and T. ammi seeds.

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Hussain, Syed Faisal Jahir, Mohammed Adil A., Durga Munireddy, and Ashok Kumar Kumar Pandurangan. "Effects of Nigella sativa and Its Active Ingredient Thymoquinone on Breast Cancer." In Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics, 249–63. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-9258-8.ch012.

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Breast cancer (BC) is the most prevalent malignancy in women. The main treatment for BC is surgery and chemotherapy. Generally, the chemotherapeutic drugs used for treatment cause numerous side effects. Substances derived from natural products have proven to exhibit anti-cancer effects without causing side effects. For instance, biochannin A found in cabbage and cauliflower reduced the growth of estrogen dependent MCF 7 cells. Another example is curcumin present in turmeric exhibits anti-proliferative and inhibitory effect against BC. The active compound of Nigella sativa is thymoquinone. The oil extracted from Nigella sativa reduced blood pressure. Nigella sativa exerts anti-pyritic, anti-inflammatory, and anti-microbial activity. Thymoquinone is found in seeds of Nigella sativa. Thymoquinone is a promising anti-neoplastic, anti-carcinogenic, anti-proliferative agent. In this chapter, the authors emphasize the anticancer potential of Nigella sativa and its derivatives and the mechanism of action against BC.

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Sadik, Saabira Banu Sahubar, Prathibha Sivaprakasam, Nishanthi Ramasami, and Ashok Kumar Pandurangan. "The Molecular Mechanisms Involved in Suppressing Triple Negative Breast Cancer Using Natural Agents." In Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics, 45–71. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-9258-8.ch003.

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Breast cancer is an aggressive and primary cause of death among women globally. Triple negative breast cancer (TNBC) is one of the sub types of breast cancer. TNBC lacks the expression of progesterone receptor (PR), estrogen receptor (ER), and human epidermal factor 2 (HER2), which leads to poor diagnosis resulting in lack of targeted therapies. On the other hand, natural products are also cost efficient, non-toxic, and abundantly available in nature. Natural products have also been reported to exert various pharmacological activities including cardioprotective, anti-diabetic, antimicrobial, anti-inflammatory, etc. In this chapter, summarization of 12 well known natural products such as chebulinic acid, maslinic acid, apigenin, piperlongumine, Liquiritigenin, berberine, icariin, bufalin, which are targeted against TNBC through regulation of different pathways, and their mechanism are briefly explained. These natural products are already used to treat various diseases at the preclinical level and also have shown to have effective anti-tumor effect and can act as potent anti-TNBC agents.

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Atti di convegni sul tema "Estrogen Therapeutic use"

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Samayoa, C., NK Krishnegowda, R. Vadlamudi та RR Tekmal. "Abstract P3-04-03: Investigating the therapeutic use of estrogen receptor β agonists in breast cancer". У Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p3-04-03.

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Ramasamy, Kumaraguruparan, Cathy Samayoa, Naveen K. Krishnegowda, Ratna K. Vadlamudi та Rajeshwar R. Tekmal. "Abstract 3616: Potential therapeutic use of Estrogen Receptor β agonist in the prevention and progression of breast cancer using HER-2/neu mouse model". У Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3616.

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Ferreri, Suzanne, and Yi-Xian Qin. "Alteration of Bone’s Nonlinear Elastic and Viscoelastic Nanomechanical Properties Is Triggered by Low Intensity Pulsed Ultrasound." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206711.

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Dynamic mechanotransduction, particularly under high frequency, low amplitude signals, has been proven effective in mediating bone loss and improving mechanical strength for tissues affected by estrogen deficient osteopenia. Ultrasound, which behaves as an alternating pressure wave in bone, may offer an effective, non-invasive technology for delivery of anabolic signals. In vitro, dynamic mechanical signals delivered using ultrasound have been shown to increase osteoblast proliferation [1], and in vivo studies have established ultrasound as an effective treatment for delayed and non-union frac

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Lima, Beatriz Alves, Andressa da Silva Pereira, Bruna Alves Lima, Diana Gonçalves Lima, Leonardo Ferreira Pucci, Renato Moraes Ferreira, Tiago Castro Ferreira, and Henrique Ferreira Pucci. "PREDICTORS OF BREAST CANCER PROGNOSIS BASED ON TUMOR BIOMARKERS." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2022.

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Objective: To analyze the tumor biological markers of breast cancer associated with the prognostic of the disease. Methodology: A systematic review was carried out on the Scielo, PubMed, and the National Cancer Institute databases on the topic. Descriptors used were: tumor biomarkers, breast cancer, and prognosis. Thus, 15 articles published between 2001 and 2020 were selected. Results: Breast cancer, characterized by the disordered multiplication of breast cells, is the most incident in women in the world, representing 24.2% of the total cases in 2018, and the most frequent cause of death in

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Nunes, Mirella Laranjeira, Carlos Eduardo Caiado Anunciação, Vidianna Barbosa Sampaio, Rossano Robério Fernandes Araújo, Cinthya Roberta Santos de Jesus, Ana Leide Guerra dos Santos, Bruno Pacheco Pereira, and João Esberard de Vasconcelos Beltrão Neto. "OCCULT PRIMARY BREAST CARCINOMA: A CASE REPORT." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2049.

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Introduction: Occult breast carcinoma (OBC) is the histologically proven axillary lymph node (LN) metastasis, consistent with primary breast cancer, with no identifiable primary site. It is most commonly found in women above 60 years. Owing to the absence of protocols, management is challenging. According to the National Comprehensive Cancer Network (NCCN), the therapeutic options are mastectomy plus lymphadenectomy with or without radiotherapy, or lymphadenectomy with breast irradiation with or without axillary irradiation. Mastectomy is often used, but advances in neoadjuvant chemotherapy ha

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Santos, Catharine Coelho, Camila Santos Farabotti, Pedro Santos Gomes, Luiz Henrique Gebrim, and André Santos Mattar. "IMMUNOHISTOCHEMICAL PROFILE STRATIFIED IN AGE RANGE IN11,326 PATIENTS FROM THE BRAZILIAN UNIFIED HEALTH SYSTEM (SUS) IN SÃO PAULO." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1047.

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Introduction: The development of breast cancer is heterogeneous and there are variations in its morphologic and biological characteristics. Several risk factors for breast cancer have already been identified, including the age group. It is wellestablished that the incidence of breast cancer increases from the age of 65. Older patients are more likely to have tumors which are positive estrogen receptors (ER) and progesterone receptors (RP) and, HER2 negative, which are associated with better outcomes. In contrast, younger patients with triple-negative breast cancer and HER2 positive are associa

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