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Articoli di riviste sul tema "Experimental trials"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Bolton, Sanford. "Experimental Design in Clinical Trials." Clinical Research and Regulatory Affairs 17, no. 4 (2000): 285–344. http://dx.doi.org/10.3109/10601330009010839.

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Fujinaka, Hidehiko, Masanori Hara, Makoto Uchiyama, et al. "Therapeutic Trials of Experimental Crescentic Glomerulonephritis." Nihon Shoni Jinzobyo Gakkai Zasshi 10, no. 1 (1997): 87–91. http://dx.doi.org/10.3165/jjpn.10.87.

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Salama, Ragga H., Abd El Rahman G. Ramadan, Tasneem A. Alsanory, Mohammed O. Herdan, Omnia M. Fathallah, and Aya A. Alsanory. "Experimental and Therapeutic Trials of Amygdalin." International Journal of Biochemistry and Pharmacology 1, no. 1 (2019): 21–26. http://dx.doi.org/10.18689/ijbp-1000105.

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4

Finkel, R. "Experimental trials in spinal muscular atrophy." Neuromuscular Disorders 27 (March 2017): S2. http://dx.doi.org/10.1016/s0960-8966(17)30224-9.

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5

Snart, Ronald S. "Human trials of experimental AIDS vaccines." AIDS 2 (1988): S107–112. http://dx.doi.org/10.1097/00002030-198800001-00016.

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6

Fast, Patricia E., and Mary Clare Walker. "Human trials of experimental AIDS vaccines." AIDS 7 (January 1992): S147—S160. http://dx.doi.org/10.1097/00002030-199201001-00020.

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Fast, Patricia E., and Mary Clare Walker. "Human trials of experimental AIDS vaccines." AIDS 7 (January 1993): S147—S160. http://dx.doi.org/10.1097/00002030-199301001-00020.

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8

Gibbs, Lauren. "Rethinking Eligibility for Experimental Clinical Trials." JAMA Neurology 75, no. 1 (2018): 22. http://dx.doi.org/10.1001/jamaneurol.2017.3492.

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9

Logvinov, Ilana. "Clinical trials transparency and the Trial and Experimental Studies Transparency (TEST) act." Contemporary Clinical Trials 37, no. 2 (2014): 219–24. http://dx.doi.org/10.1016/j.cct.2014.01.001.

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Fisher, Dwight S. "Defining the experimental unit in grazing trials." Journal of Animal Science 77, E-Suppl (2000): 1. http://dx.doi.org/10.2527/jas2000.00218812007700es0006x.

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11

Cooper, M. "Experimental Labour--Offshoring Clinical Trials to China." East Asian Science, Technology and Society 2, no. 1 (2008): 73–92. http://dx.doi.org/10.1215/s12280-008-9040-y.

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Sprenger, Jan. "Evidence and Experimental Design in Sequential Trials." Philosophy of Science 76, no. 5 (2009): 637–49. http://dx.doi.org/10.1086/605818.

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Naficy, A. B., J. D. Clemens, and M. R. Rao. "Randomized controlled clinical trials of experimental vaccines." Bulletin de l'Institut Pasteur 95, no. 4 (1997): 187–96. http://dx.doi.org/10.1016/s0020-2452(97)83527-1.

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Reintgen, Douglas, Jeanne Becker, and Hilliard F. Seigler. "Experimental trials of immunotherapy for malignant melanoma." Seminars in Surgical Oncology 7, no. 4 (1991): 192–98. http://dx.doi.org/10.1002/ssu.2980070404.

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15

PV, Indu, and Vidhukumar K. "Experimental studies: Randomized controlled trials – Part I." Kerala Journal of Psychiatry 35, no. 2 (2023): 384. http://dx.doi.org/10.30834/kjp.35.2.2023.384.

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16

Cooper, Melinda. "Experimental Labour—Offshoring Clinical Trials to China." East Asian Science, Technology and Society: an International Journal 2, no. 1 (2008): 73–92. http://dx.doi.org/10.1007/s12280-008-9040-y.

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17

Doussau, Adélaïde, Isha Agarwal, Tito Fojo, Ian F. Tannock, and Christine Grady. "Design of placebo-controlled randomized trials of anticancer agents: Ethical considerations based on a review of published trials." Clinical Trials 18, no. 6 (2021): 690–98. http://dx.doi.org/10.1177/17407745211052474.

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Background Limited information exists about the design of placebo-controlled cancer trials. Through a systematic review of trials published in 2013, we describe placebo use in randomized trials testing anticancer agents and analyze strategies that increase exposure to the experimental regimen. Methods Trials were classified as add-on (placebo in combination with standard treatment) or placebo-only. Strategies to allow more than half of the participants to receive the experimental regimen were reviewed. The risk–benefit ratio of receiving the experimental agent was considered favorable if the d

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18

Cicchetti, Americo, Domenico Addesso, Filippo Elvino Leone, et al. "Valorization of clinical trials from the Italian National Health Service perspective: definition and first application of a model to estimate avoided costs." Global & Regional Health Technology Assessment 7, no. 1 (2020): 26–32. http://dx.doi.org/10.33393/grhta.2020.709.

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 Introduction: From the perspective of healthcare organizations and public health care systems, the value of a clinical trial can be assessed from a clinical and economical perspective. However, to date, there is no standardized model for systematically capturing the economic value of clinical trials at organizational and system levels. The aim of this study was to develop and test a methodology for estimating the avoided costs deriving from the management of patients as part of a clinical trial. Methods: Our methodology is based on the assumption that the economic value of a clini

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19

Chugh, Rashmi. "Experimental Therapies and Clinical Trials in Bone Sarcoma." Journal of the National Comprehensive Cancer Network 8, no. 6 (2010): 715–25. http://dx.doi.org/10.6004/jnccn.2010.0052.

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Sarcomas originating in the bone represent a challenge for physicians and patients. Because they constitute only 0.2% of all adult malignancies and 6% of pediatric malignancies, resources for studying this disease are often limited.1,2 Nonetheless, significant advancements have been made in the treatment of this disease, and there are ongoing efforts toward improvement. This article discusses recently completed and currently enrolling clinical trials for the 3 most common bone sarcomas: osteosarcoma, Ewing's sarcoma family tumors, and chondrosarcoma.

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20

NAKAMURA, Takehiro, Anass BENJEBBOUR, Yoshihisa KISHIYAMA, Satoshi SUYAMA, and Tetsuro IMAI. "5G Radio Access: Requirements, Concept and Experimental Trials." IEICE Transactions on Communications E98.B, no. 8 (2015): 1397–406. http://dx.doi.org/10.1587/transcom.e98.b.1397.

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21

Tadokoro, Yasuho. "The Experimental Trials against “the Chattonella Red Tide”." Japan journal of water pollution research 12, no. 4 (1989): 225–29. http://dx.doi.org/10.2965/jswe1978.12.225.

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22

Nemeth, Balazs T., Zoltan V. Varga, Wen Jin Wu, and Pal Pacher. "Trastuzumab cardiotoxicity: from clinical trials to experimental studies." British Journal of Pharmacology 174, no. 21 (2016): 3727–48. http://dx.doi.org/10.1111/bph.13643.

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23

Uchida, E., T. Aimoto, Y. Nakamura, et al. "HAMSTER PANCREATIC CANCER MODEL FOR EXPERIMENTAL THERAPEUTIC TRIALS." Pancreas 35, no. 4 (2007): 431–32. http://dx.doi.org/10.1097/01.mpa.0000297800.73046.b9.

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Marini, Richard P. "Experimental Designs and Statistical Analyses for Rootstock Trials." Agronomy 14, no. 10 (2024): 2312. http://dx.doi.org/10.3390/agronomy14102312.

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Abstract (sommario):

Modern agricultural research, including fruit tree rootstock evaluations, began in England. In the mid-1800s, field plots were established at the Rothamsted Research Station to evaluate cultivars and fertilizer treatments for annual crops. By the early 1900s, farmers questioned the value of field experimentation because the results were not always valid due to inadequate randomization and replication and poor data summarization. During the first half of the 20th century, Rothamsted statisticians transformed field plot experimentation. Field trials were tremendously improved by incorporating ne

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25

Fayers, Peter M. "Randomization in clinical trials and experimental molecular medicine." Molecular Medicine Today 2, no. 9 (1996): 366–68. http://dx.doi.org/10.1016/s1357-4310(96)20023-1.

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26

Guénette, Chantal C., Gary A. Sergy, Edward H. Owens, Roger C. Prince, and Kenneth Lee. "Experimental design of the Svalbard shoreline field trials." Spill Science & Technology Bulletin 8, no. 3 (2003): 245–56. http://dx.doi.org/10.1016/s1353-2561(03)00038-0.

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Talbot, George H., Maureen Skros, and Mary Provencher. "70% Alcohol Disinfection of Transducer Heads: Experimental Trials." Infection Control 6, no. 6 (1985): 237–39. http://dx.doi.org/10.1017/s0195941700061609.

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AbstractWe investigated the feasibility of transducer head disinfection with 70% alcohol wipes. In the initial trial, nine gas-sterilized transducers were inoculated with an estimated 5 × 106 organisms of a clinical isolate of Enterobacter cloacae, mimicking a contaminated fluid couple. A sterile disposable transducer dome was attached to each transducer. The units were allowed to sit for 24 hours at room temperature; the domes were then removed. Three transducer heads were cultured prior to disinfection to ensure that viable organisms remained. Each transducer head was wiped clean with a sing

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28

Katsileros, Anastasios, and Christos Koukouvinos. "Evaluation of experimental designs in durum wheat trials." Biometrical Letters 52, no. 2 (2015): 105–14. http://dx.doi.org/10.1515/bile-2015-0010.

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Abstract Variability among experimental plots may be a relevant problem in field genotype experiments, especially when a large number of entries are involved. Four field trials on 24 durum wheat genotypes were conducted in 2013/14 in order to evaluate the efficiency of Incomplete Block, Alpha and Augmented designs in comparison with the traditional Randomized Complete Block Design (RCBD). The results showed that the RCBD can be replaced by an Alpha design, which provides better control of variability among the experimental units when the number of treatments to be tested in an experiment excee

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29

Bellin, Eran. "Non-Placebo Controlled HIV Experimental Trials in Prisoners." Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology 9, no. 3 (1995): 315. http://dx.doi.org/10.1097/00042560-199507000-00019.

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Varghese, Cini, Eldho Varghese, Seema Jaggi, and Arpan Bhowmik. "Experimental designs for open pollination in polycross trials." Journal of Applied Statistics 42, no. 11 (2015): 2478–84. http://dx.doi.org/10.1080/02664763.2015.1043860.

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31

Detre, Katherine M. "Design of Clinical Trials." Prehospital and Disaster Medicine 1, S1 (1985): 33–35. http://dx.doi.org/10.1017/s1049023x00043697.

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A Controlled Clinical Trial is the formal experimental approach to treatment evaluation. In such a trial, the investigator controls the assignment of treatments—ideally by randomization— to experimental groups. When well executed, such a trial provides the strongest evidence for the relative effectiveness of the different therapeutic interventions. Some people, myself among them, believe that the clinical trial approach should be used early when a new therapeutic modality is first introduced.The purpose of a controlled clinical trial is to answer the question of whether the new therapy is pref

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32

Uchida, Eiji, Akira Matsushita, Ken Yanagi, et al. "Experimental Pancreatic Cancer Model Using PGHAM-1 Cells: Characteristics and Experimental Therapeutic Trials." Journal of Nippon Medical School 75, no. 6 (2008): 325–31. http://dx.doi.org/10.1272/jnms.75.325.

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33

Ali Khan, Javed, and Pathan Jamal Khan. "AN OVERVIEW OF RANDOMIZATION IN CLINICAL TRIALS." International Journal of Advanced Research 8, no. 12 (2020): 35–36. http://dx.doi.org/10.21474/ijar01/12123.

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Randomization is a process of assigning the treatments to various experimental units in a purely chance manner to the control and treatment groups in clinical trials. The process of reducing the experimental error by dividing the relatively heterogeneous experimental units in to homogeneous blocks is known as local control. This paper describes some of the main steps in those performing reviewers of randomized controlled trials (RCT).

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34

Tabandeh, Homayoun, and David Boyer. "Experimental Treatments for Diabetic Macular Edema." US Ophthalmic Review 04, no. 02 (2011): 125. http://dx.doi.org/10.17925/usor.2011.04.02.125.

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Diabetic macular edema (DME) is the most common reason for the loss of reading vision in diabetes patients. Systemic control of blood sugar, blood pressure, and lipids is an important aspect of the management of DME. In these patients, macular laser photocoagulation has been shown to reduce the incidence of moderate visual loss by 50 %. Significant visual improvement occurs in a small minority. Other treatment modalities, such as intravitreal steroids and anti-vascular endothelial growth factor (VEGF) drugs, have become increasingly popular. Case series and small clinical studies are suggestiv

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35

Storck, Lindolfo, Sidinei José Lopes, Alberto Cargnelutti Filho, Alessandro Dal'Col Lúcio, and Marcos Toebe. "Experimental precision in corn trials using the Papadakis method." Ciência e Agrotecnologia 34, no. 6 (2010): 1458–64. http://dx.doi.org/10.1590/s1413-70542010000600015.

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The objective of this work was to verify whether the use of the Papadakis method in competing corn hybrid trials would lead to modifications in the validity of assumptions for the mathematical model of variance analysis and for experimental precision indicators. To achieve this, corn-grain-yield data from 25 competing corn hybrid trials, performed in a design of complete randomized blocks, were examined. Each trial entailed verification of assumptions, variance analysis, hypothesis tests, statistics to identify experimental precision, and analysis using the Papadakis method. This method improv

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36

Blackwell, Simon E., and Marcella L. Woud. "Making the leap: From experimental psychopathology to clinical trials." Journal of Experimental Psychopathology 13, no. 1 (2022): 204380872210800. http://dx.doi.org/10.1177/20438087221080075.

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One important aim of experimental psychopathology research is to inform development of new interventions derived from basic science. However, testing whether a newly developed intervention is in fact effective requires moving from experimental studies to clinical trials, and this transition can pose many problems. These problems stem not only from the inherent complexity of even the simplest clinical trial but also from differences between experimental psychopathology and clinical trial research that may not always be obvious to researchers immersed in only one of these specialist areas. In th

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37

Hemant A. Kinikar, A.B. Kanase-Patil, Tushar A. Jadhav, and Dr. S. S. Thipse. "Experimental Assessment of Genset Performance for PCCI-DI Combustion Engine." ARAI Journal of Mobility Technology 3, no. 4 (2023): 835–41. http://dx.doi.org/10.37285/ajmt.3.4.6.

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Applying the PCCI-DI combustion concept which can yield low emissions is tried for vehicular applications. However, much work has not been carried out on the genset engine which is a constant speed application. The PCCI can be achieved by various methods like port injection, late direct injection, early direct injection, and multiple direct injections to name a few. However in this case, it is achieved using the port injection. The two different port injection quantities are tried out. The first is with 3 ms pulse and the other with 5 ms pulse of port injection. In this study, PCCI-DI engine i

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38

Islam, Nadia. "Safety and efficacy of Combination of Fludarabine, Cyclophosphamide, and Rituximab compared to Chemotherapy alone in Chronic Lymphocytic Leukemia Patients." International Journal of Multidisciplinary Research and Growth Evaluation 6, no. 3 (2025): 1423–31. https://doi.org/10.54660/.ijmrge.2025.6.3.1423-1431.

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Background: Chronic lymphocytic leukemia, one of the most common hematological malignancies, has been treated with several treatment regimens. Recently chemoimmunotherapy with Fludarabine, Cyclophosphamide, and Rituximab (FCR) regimen have shown significant success in treating these patients. Aim: This systematic review aims compare the efficacy and safety of chemoimmunotherapy combination (FCR) to chemotherapy alone (FC) in chronic lymphocytic leukemia patients. Methods: Three healthcare related databases were systematically searched: PubMed, Cochrane registry for clinical trials, and cumulat

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39

Tinè, Fabio, Massimo Attanasio, Vito M. R. Muggeo, and Ciprian M. Crainiceanu. "Evidence of bias in randomized clinical trials of hepatitis C interferon therapies." Clinical Trials 14, no. 5 (2017): 483–88. http://dx.doi.org/10.1177/1740774517715447.

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Introduction: Bias may occur in randomized clinical trials in favor of the new experimental treatment because of unblinded assessment of subjective endpoints or wish bias. Using results from published trials, we analyzed and compared the treatment effect of hepatitis C antiviral interferon therapies experimental or control. Methods: Meta-regression of trials enrolling naïve hepatitis C virus patients that underwent four therapies including interferon alone or plus ribavirin during past years. The outcome measure was the sustained response evaluated by transaminases and/or hepatitis C virus-RNA

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Rossi, Lucas Félix, Renata Ribeiro Ramos, Jorge Bins Ely, et al. "Considerations that may influence the result of trials assessing tensile strength in experimental surgery." Acta Cirurgica Brasileira 22, no. 6 (2007): 499–502. http://dx.doi.org/10.1590/s0102-86502007000600015.

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PURPOSE: To provide information gathered upon the execution of trials assessing tensile strength in experimental surgeries. METHODS: Descriptive study considering details on the execution of trials assessing tensile strength in experimental surgery. RESULTS: The analysis of the rupture force in a mechanical test machine is an adequate technique since it provides precise and quick results. It can, undoubtedly, be developed in this context of the eminently mechanical analysis of trials on experimental surgery. CONCLUSION: The utilization of a mechanical test machine is a useful tool in the asses

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41

Pearl, Judea. "Generalizing Experimental Findings." Journal of Causal Inference 3, no. 2 (2015): 259–66. http://dx.doi.org/10.1515/jci-2015-0025.

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AbstractThis note examines one of the most crucial questions in causal inference: “How generalizable are randomized clinical trials?” The question has received a formal treatment recently, using a non-parametric setting, and has led to a simple and general solution. I will describe this solution and several of its ramifications, and compare it to the way researchers have attempted to tackle the problem using the language of ignorability. We will see that ignorability-type assumptions need to be enriched with structural assumptions in order to capture the full spectrum of conditions that permit

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42

Hamilton, E. P., G. H. Lyman, S. Kim, and J. Peppercorn. "Availability of experimental therapy outside of randomized clinical trials in oncology." Journal of Clinical Oncology 27, no. 15_suppl (2009): 6539. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6539.

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6539 Background: Investigational cancer therapies may be available outside of trials, or “off protocol” (OPRx), with implications for patient safety, trial accrual, and access to care. Previous studies suggest OPRx is prevalent in oncology, but there is little consensus on when it should or should not be considered. We evaluated the scope and impact of OPRx through assessment of availability of the experimental arms of recent randomized trials (RCT), and evaluation of study outcomes and accrual. Methods: We conducted a Medline search to identify all English language phase III RCT of medical in

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Menefee, Michael E., Yutao Gong, Pallavi Shruti Mishra-Kalyani, et al. "Project Switch: Docetaxel as a potential synthetic control in metastatic non-small cell lung cancer (mNSCLC) trials." Journal of Clinical Oncology 37, no. 15_suppl (2019): 9105. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.9105.

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9105 Background: Docetaxel is a common comparator arm to test novel therapies in post-platinum mNSCLC trials. The advent of Real World Evidence (RWE) has renewed interest in the use of synthetic control arms (control arms from previously conducted randomized trials) to improve accrual to trials and increase patient access of promising experimental agents. We reviewed legacy second-line (2L) mNSCLC trials to assess the impact of switching docetaxel control arms from one trial to another and compare to an experimental regimen. Methods: We identified 5 contemporary 2L trials that enrolled 2013 pa

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44

Bikundo, Edwin. "Experimental Norms: Power–Knowledge, Bare Life and Medical Trials." Law, Technology and Humans 2, no. 2 (2020): 42–52. http://dx.doi.org/10.5204/lthj.1712.

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Humans experimenting on other humans sits precisely at the junction of law, technology and the humanities, synthesising descriptive, normative and creative elements in relation to reality. Experiments describe reality, normalise shared conceptions of reality as well as create their own reality. Human experiments consequently inflect both ‘norm’ and ‘humanity’ as a pattern or as a model, or even a standard to be met or fulfilled. Experiments abound in Italian philosopher Giorgio Agamben’s body of work, including where he engages with the capacity for development of Michel Foucault’s opus. This

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Carlsson, J., and B. Pehrson. "Experimental Trials Assessed by Two Different Protein Evaluation Systems." Acta Veterinaria Scandinavica 35, no. 2 (1994): 193–205. http://dx.doi.org/10.1186/bf03548347.

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Perevezentsev, A. N., A. C. Bell, L. A. Rivkis, et al. "Experimental Trials of Methods for Metal Detritiation for JET." Fusion Science and Technology 52, no. 1 (2007): 84–99. http://dx.doi.org/10.13182/fst07-16.

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Forrester, Stephanie E. "Selecting the number of trials in experimental biomechanics studies." International Biomechanics 2, no. 1 (2015): 62–72. http://dx.doi.org/10.1080/23335432.2015.1049296.

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48

Simpson, Jennifer E., Corrine M. Folsom-O'Keefe, James E. Childs, Leah E. Simons, Theodore G. Andreadis, and Maria A. Diuk-Wasser. "Avian Host-Selection by Culex pipiens in Experimental Trials." PLoS ONE 4, no. 11 (2009): e7861. http://dx.doi.org/10.1371/journal.pone.0007861.

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Peterson, Arthur V., Sue L. Mann, Kathleen A. Kealey, and Patrick M. Marek. "Experimental Design and Methods for School-Based Randomized Trials." Controlled Clinical Trials 21, no. 2 (2000): 144–65. http://dx.doi.org/10.1016/s0197-2456(99)00050-1.

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Mojon, M., C. Saura, N. Roojee, and R. Tran Manh Sung. "An experimental model for therapeutic trials of anthelminthic drugs." Journal of Antimicrobial Chemotherapy 19, no. 1 (1987): 73–77. http://dx.doi.org/10.1093/jac/19.1.73.

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