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Letteratura scientifica selezionata sul tema "Fu ci"

Autore: Grafiati

Pubblicato: 25 luglio 2024

Ultima modifica: 31 luglio 2025

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Articoli di riviste sul tema "Fu ci"

Kim, Hoyon, Jamie C. Little, Jiashen Li, Bryna Patel, and Daniel Kalderon. "Hedgehog-stimulated phosphorylation at multiple sites activates Ci by altering Ci–Ci interfaces without full Suppressor of Fused dissociation." PLOS Biology 23, no. 4 (2025): e3003105. https://doi.org/10.1371/journal.pbio.3003105.

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Hedgehog (Hh) proteins elicit dose-dependent transcriptional responses by binding Patched receptors to activate transmembrane Smoothened (Smo) proteins. Activated Smo inhibits Ci/Gli transcription factor phosphorylation by Protein Kinase A and consequent proteolytic processing to repressor forms; it also promotes nuclear transport and activity of full-length Ci/Gli proteins to induce Hh target genes. Smo-activated Fused (Fu) kinase drives Ci activation in Drosophila, while Suppressor of Fused (Su(fu)) counters full-length Ci/Gli activity and stabilizes full-length Ci/Gli by direct binding to a

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Methot, N., and K. Basler. "Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus." Development 127, no. 18 (2000): 4001–10. http://dx.doi.org/10.1242/dev.127.18.4001.

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Hedgehog controls the expression of key developmental genes through the conversion of the transcription factor Cubitus interruptus (Ci) into either an activator (Ci[act]) or a repressor (Ci[rep]) form. Proteolytic cleavage of full-length Ci is important for the generation of Ci[rep], but little is known about how Ci[act] arises in response to Hh. Here we examine Hh signal transduction components for their role in the conversion of full-length Ci into either Ci[act] or Ci[rep]. We report that Cos2, PKA and Fused are necessary for the generation of Ci[rep], whereas the inhibition of either Cos2

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Zhou, Mengmeng, Yuhong Han, Bing Wang, Yong Suk Cho, and Jin Jiang. "Dose-dependent phosphorylation and activation of Hh pathway transcription factors." Life Science Alliance 5, no. 11 (2022): e202201570. http://dx.doi.org/10.26508/lsa.202201570.

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Graded Hedgehog (Hh) signaling is mediated by graded Cubitus interruptus (Ci)/Gli transcriptional activity, but how the Hh gradient is converted into the Ci/Gli activity gradient remains poorly understood. Here, we show that graded Hh induces a progressive increase in Ci phosphorylation at multiple Fused (Fu)/CK1 sites including a cluster located in the C-terminal Sufu-binding domain. We demonstrated that Fu directly phosphorylated Ci on S1382, priming CK1 phosphorylation on adjacent sites, and that Fu/CK1-mediated phosphorylation of the C-terminal sites interfered with Sufu binding and facili

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Köhne, C.-H., J. Wils, M. Lorenz, et al. "Randomized Phase III Study of High-Dose Fluorouracil Given As a Weekly 24-Hour Infusion With or Without Leucovorin Versus Bolus Fluorouracil Plus Leucovorin in Advanced Colorectal Cancer: European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952." Journal of Clinical Oncology 21, no. 20 (2003): 3721–28. http://dx.doi.org/10.1200/jco.2003.11.122.

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Purpose: This trial was conducted to determine whether high-dose fluorouracil (FU) given as a weekly 24-hour infusion is more active than bolus FU + leucovorin (LV), and whether high-dose infusional FU can be modulated by LV. Patients and Methods: A total of 497 patients with previously untreated metastatic colorectal cancer were randomly assigned to receive bolus FU 425 mg/m2 intravenously + LV 20 mg/m2 on days 1 to 5 and repeated on day 28 (FU + LV), or FU 2,600 mg/m2 as a 24-hour infusion alone (FU24h) or in combination with 500 mg/m2 LV (FU24h + LV)—all given weekly ×6 followed by a 2-week

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Kabbinavar, Fairooz, Herbert I. Hurwitz, Louis Fehrenbacher, et al. "Phase II, Randomized Trial Comparing Bevacizumab Plus Fluorouracil (FU)/Leucovorin (LV) With FU/LV Alone in Patients With Metastatic Colorectal Cancer." Journal of Clinical Oncology 21, no. 1 (2003): 60–65. http://dx.doi.org/10.1200/jco.2003.10.066.

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Purpose: This phase II trial investigated the safety and efficacy of two doses of bevacizumab, a monoclonal antibody to vascular endothelial growth factor, plus fluorouracil (FU)/leucovorin (LV) versus FU/LV alone in patients with metastatic colorectal cancer. Patients and Methods: One hundred four previously untreated patients with measurable metastatic colorectal cancer were randomly assigned to one of the following three treatment groups: 36 to FU (500 mg/m2)/LV (500 mg/m2) alone, 35 to FU/LV + low-dose bevacizumab (5 mg/kg every 2 weeks), and 33 to FU/LV + high-dose bevacizumab (10 mg/kg e

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Ku, Geoffrey Yuyat, Benjamin Haaland, and Gilberto de Lima Lopes. "Cetuximab (C225) in the first-line treatment of advanced colorectal cancer (CRC) patients (Pts) with K-ras wild-type (WT) tumors: Does the choice and schedule of fluoropyrimidine (Fp) matter?" Journal of Clinical Oncology 30, no. 4_suppl (2012): 576. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.576.

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576 Background: C225, a monoclonal antibody against the epidermal growth factor receptor, has been shown to inconsistently improve response rates (RR), progression-free survival (PFS) and overall survival (OS) in the first-line treatment of advanced CRC Pts with K-ras WT tumors. Methods: We performed a meta-analysis of four trials where K-ras WT Pts received a Fp (capecitabine (C) or bolus (b) or infusional (CI) 5-fluorouracil (5-FU)) and oxaliplatin (oxali) or irinotecan (CPT) ± C225 (CRYSTAL, OPUS, COIN and NORDIC VII trials) and one trial, where K-ras WT and mutant Pts received C225 with ca

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Wang-Gillam, Andrea, Chung-Pin Li, Gyorgy Bodoky, et al. "Updated overall survival analysis of NAPOLI-1: Phase III study of nanoliposomal irinotecan (nal-IRI, MM-398), with or without 5-fluorouracil and leucovorin (5-FU/LV), versus 5-FU/LV in metastatic pancreatic cancer (mPAC) previously treated with gemcitabine-based therapy." Journal of Clinical Oncology 34, no. 4_suppl (2016): 417. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.417.

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417 Background: NAPOLI-1 is a global, randomized Phase 3 study evaluating nal-IRI—a nanoliposomal irinotecan—with or without 5-FU/LV in 417 patients with mPAC previously treated with gemcitabine-based therapy. Primary survival analysis was based on 313 events. Nal-IRI+5FU/LV significantly improved overall survival (OS, primary endpoint), 6.1 months (mo) vs 4.2 mo; with 5-FU/LV (unstratified hazard ratio [HR] = 0.67; P = 0.012). Primary endpoint was supported by improved progression-free survival, time to treatment failure, objective response and CA19-9 tumor marker response rates, and manageab

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Wagner, Anna D., Wilfried Grothe, Johannes Haerting, Gerhard Kleber, Axel Grothey, and Wolfgang E. Fleig. "Chemotherapy in Advanced Gastric Cancer: A Systematic Review and Meta-Analysis Based on Aggregate Data." Journal of Clinical Oncology 24, no. 18 (2006): 2903–9. http://dx.doi.org/10.1200/jco.2005.05.0245.

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Purpose This systematic review and meta-analysis were performed to assess the efficacy and tolerability of chemotherapy in patients with advanced gastric cancer. Methods Randomized phase II and III clinical trials on first-line chemotherapy in advanced gastric cancer were identified by electronic searches of Medline, Embase, the Cochrane Controlled Trials Register, and Cancerlit; hand searches of relevant abstract books and reference lists; and contact to experts. Meta-analysis was performed using the fixed-effect model. Overall survival, reported as hazard ratio (HR) with 95% CI, was the prim

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Arkenau, Hendrik-Tobias, Dirk Arnold, Jim Cassidy, et al. "Efficacy of Oxaliplatin Plus Capecitabine or Infusional Fluorouracil/Leucovorin in Patients With Metastatic Colorectal Cancer: A Pooled Analysis of Randomized Trials." Journal of Clinical Oncology 26, no. 36 (2008): 5910–17. http://dx.doi.org/10.1200/jco.2008.16.7759.

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PurposeSix randomized phase II and III trials have investigated the role of oxaliplatin (OX) in combination with capecitabine (CAP) or infusional fluorouracil (FU) in metastatic colorectal cancer. This meta-analysis compared the efficacy of CAP/OX compared with infusional FU/OX.Patients and MethodsThis analysis compared all published CAP/OX versus infusional FU/OX regimens. A total of 3,494 patients (FU, n = 1,737; CAP, n = 1,757) were analyzed for response rate (RR), progression-free (PFS), overall survival (OS), and toxicity.ResultsThe fixed-effect pooled estimate for RR showed higher RR for

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Nam, Ki-Woong, Chi Kyung Kim, Tae Jung Kim, et al. "FLAIR vascular hyperintensities predict early ischemic recurrence in TIA." Neurology 90, no. 9 (2018): e738-e744. http://dx.doi.org/10.1212/wnl.0000000000005034.

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ObjectiveTo evaluate the relationship between fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) and early ischemic lesion recurrence (follow-up diffusion-weighted imaging [FU-DWI] [+]) in patients with lesion-negative TIA.MethodsWe recruited consecutive patients with lesion-negative TIA within 24 hours of symptom onset, who underwent follow-up MRI during the acute period. FVH was defined as a focal or serpentine high signal intensity on FLAIR images. Other potential confounders were adjusted to evaluate the relationship between FVH and FU-DWI (+). Furthermore, to compar

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Più fonti

Tesi sul tema "Fu ci"

Chen, Min-Chu, and 陳民珠. "The Research On Wang,Fu-zhi''s Jiang-Zhai Ci." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/36064492030948343152.

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蕭岳煊. "A study of Feng Weimin’s "Hai Fu Shan Tan Ci Gao"." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/54nhra.

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Yeh, Yiang-yin, and 葉亮吟. "A Study on the Creative Writings of Su Shi’s “Ci”and “Fu” Poetry." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/32549906268857509177.

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Duk, Yang Seoung, and 梁承德. "A Study on The theory of Ci Fu in Wei Jin Southern Northern Dynasty." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/18280292973029020302.

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Siao, Wan-Ru, and 蕭琬茹. "Cross-Genre Writing: Essay, Fu and Qu Inheritance and Innovation Of Shih-Chuan Ciang’s Tung-Hsien Ci." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/6p5385.

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碩士 國立中興大學 中國文學系所 101 英文摘要 This dissertation aims to investigate the cross-genre writing of 《Tung-Hsien Ci》 among prose, Fu (poetry) and Qu (poetry). In terms of turning the prose into “Ci (poetry),” it discusses the grand style of Chia-Hsuan Ci, mixed with prose syntaxes. As for the turning from Fu to Qu, this article chooses the Ci of Elegant Cial School in Song Dynasty as a contrast to Tung-Hsien Ci. Although there are differences in terms of the style between the two, both of them are mainly chant. Dealing with the turning of Ci to Qu, taking the Ci of Ming Dynasty and Tung Hs

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I-ChiaChen and 陳怡嘉. "A Study of Shuo Tang Gu Ci “Story of Qin Qiong’s Visit and Disturbance in Tai Yuan Fu with illustration”." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/17243807172670894329.

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碩士 國立成功大學 中國文學系碩博士班 98 The ancient history stories about the heroes fought for power at the end of Sui Dynasty and at the beginning of Tang Dynasty had a great development among Chinese classic novels, dramas, and other forms of literature. For example, “Shuo Tang Quan Zhuan” which was collated by Yun Hu Yu Sou of Cing Dynasty (abbr. “Shuo Tang”) was very popular among people. Many stories of Folk Literature were based on its plots. When it comes to the study of “Shuo Tang”, many researchers were focus on contrasting the different plots of “Shuo Tang” and other series novels of Sui

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Libri sul tema "Fu ci"

ping, Xu yi. Fu ci. Wai yu jiao xue yu yan jiu chu ban she, 1997.

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Songlin, Huo, and Xu Zongwen, eds. Ci fu da ci dian. Jiangsu gu ji chu ban she, 1996.

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Xie, Jun. Fu li ci. s.n., 1990.

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Zeng, Zao. Yue fu ya ci: Fu shi yi. Zhonghua shu ju, 1985.

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Lu, Sanqiang, and Zao Zeng. Yue fu ya ci. Liaoning jiao yu chu ban she, 1997.

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Zhongding, Luo, and Yu Huanping, eds. Fu tang ci lu. Zhejiang gu ji chu ban she, 2018.

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Deveraux, Jude. Tian ci zhi fu. Lin bai chu ban she you xian gong si, 2000.

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Gengyuan, Wei, and Xue Lian, eds. Wan jia ci fu. Zhongguo she hui chu ban she, 2004.

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Xu, Qinwen. Fang fu ru ci. Beijing zhong xian tuo fang ke ji fa zhan you xian gong si, 2012.

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Qing, Yu. Tian guan ci fu. Xing he chu ban she, 2001.

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Capitoli di libri sul tema "Fu ci"

Bajini, Irina. "Un gentiluomo tra i Navigli e la laguna. Alejandro Alonso e l’arte della cubanía rivoluzionaria." In isola che ci abita La isla que nos habita. Milano University Press, 2024. http://dx.doi.org/10.54103/criando.200.c342.

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Con questo contributo mi propongo di tracciare la traiettoria vitale e scientifica di un intellettuale cubano di grande spessore. Uno studioso sui generis, un maestro malgré lui.Alejandro Alonso (1935-2017) fu un giornalista cubano e un critico d’arte, di cinema, di balletto. Fondò e diresse il museo del-la ceramica artistica dell’Avana e pubblicò diverse monografie, tra cui Cosas y casas de Cuba. Habana Deco, Alfredo Sosabravo, Amelia Peláez.Di origini spagnole, era innamorato della sua isola, nonostante ostentasse modi e abiti d’antan. In molti lo rimpiangono, perché quando era un amico era

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Letta, Cesare. "C.D. 41.51.7-8 alla luce dei fasti Privernates. Nota sui magistri equitum di Cesare dittatore perpetuo." In Organizzare il tempo. Fasti e calendari a Roma e nell’Italia romana. Milano University Press, 2025. https://doi.org/10.54103/consonanze.218.c358.

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Il passo di Dione (43.5.6-8) sui magistri equitum designati da Cesare dittatore perpetuo sarebbe pienamente compatibile con le nuove informazioni fornite dai Fasti Privernates se, secondo un uso linguistico ampiamente documentato in Dione, si corregge il tràdito ἄλλον τέ τινα καὶ τὸν Ὀκτάουιον in ἄλλο<υς> τέ τινα<ς> καὶ τὸν Ὀκτάουιον. Al § 7, dunque, Dione non parlerebbe di due soli magistri equitum annuali per un periodo di tre o quattro anni, ma genericamente di un numero imprecisato di magistri, tra i quali, oltre a Ottavio e agli altri magistri annuali non nominati, deve consid

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Iannaccone, Philip, Robert Holmgren, Marilyn L. G. Lamm, et al. "The Sonic Hedgehog Signaling Pathway." In Inborn Errors Of Development. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195306910.003.0019.

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Abstract The highly conserved hedgehog (Hh) family of signaling proteins triggers crucial processes in early vertebrate and invertebrate development, including cell fate speci7cation, patterning, and organogenesis. The development of a large number of organ systems is directly affected by the Hh signaling pathway. Indeed, the Hh ligands, patched and smoothened transmembrane proteins, and the Ci/Gli family of transcription factors are at the nexus of mesodermal development and they are critical to epithelial–mesenchymal interactions throughout the body. It is also becoming clear that a relative

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"upstream portion of a river basin can also extend For example, the supply of some economic good ldo ownstream as reduced streamflow may result in (e.g., water, hay, hydroelectric power) is weather n lo o c we tateirorxness , erevvoeinratnhdouggrhoum ndwater levels at downstream dependent. In most instances, the dema ist in this portion oef te tohreolboagsiicna . lRde ro duug ct h io tndsoe in sagn oo d d /o irsipnecrrecaasp in it gaacsoansru es mup lt tioofni . n T cr heearse in fo grnpd for tha e, opdu ro la utg io hnt reservoir and groundwater levels in downstream could be defined as occurring when the demand for tppuob rt liiocns of th duction, wraetcerre basin e at siuopnp , l ie msa , y h re ysdurlote in s transportati loenc , terr ic io us p o im w pacts on that good exceeds supply as a result of a weather-ot agricultu erre , parnod rceelpatteodfsdurpopu ly ghstho su rt p fa plol rt ( sSatnhde fo srtd ro n1g97s9y ) m . b T io hsiissctohn at m str heearms ectors. Conflicts between upstream and down exists between drought and human activities. Thus, 19 a9n4yfr wa o iv retrerb use an eaxsa in rss may mpl ienftrhree su U lt, as has been the case in the incidence of drought could increase be om th nei te MdisS so ta utreisR ( isveeerBOapsp in e ) r . cchha an ng gee in in so th ci e e ta flrevquu ln en er cayb il o it fytthoewpah te yrsischaolcaeuvseenot, faaw In h te errneartiivoen rs altrw an astceernddisnpau ti te osnaolfb te onrdaerriss , e su in chsiatsu atio rtages, or Middle East or between the United States ina th nesb ov o e th rg . r For example, nd increas aezs in o g il cea ro nsd io e n cr epao se oran la im nd a -l ucsaer ry pr in ac g tice , which exacerbates th ceaipsacsiu ty chanads Me T xi hceo . discussion up to this point has focused on the a es npdecviu al llnyerraeblielv it aynttoin fu t s ure droughts. This e m xa p m ac ptlseo is fodn is ste inctions between the types of drought during its Africa, Australia) and e in miaarre id a s re ogfiohnis ll y ( e o .g r ., sl Soopu in th g phase t or development pha drough otfd ty rpoeusgm ht a , y th deififnetre . rsree . l a During the termination terrain (e.g., Lesotho). understanding the termin Faitg io u ti roe nships between these During drought onset, agricul n tu p1h . a4se is sao ls fodurso ef uuglhitn ." In Droughts. Routledge, 2016. http://dx.doi.org/10.4324/9781315830896-30.

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Atti di convegni sul tema "Fu ci"

Mudiganti, J. C., T. Idehara, Y. Tatematsu, et al. "Design of a 394.6 GHz compact gyrotron FU CW CI for 600 MHz DNP-NMR spectroscopy." In 2011 36th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz 2011). IEEE, 2011. http://dx.doi.org/10.1109/irmmw-thz.2011.6105136.

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Mudiganti, J., T. Idehara, R. Ikeda, et al. "Compact gyrotron FU CW CI for 600 MHz DNP-NMR spectroscopy and hybrid quantum beam technologies." In 2012 37th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz 2012). IEEE, 2012. http://dx.doi.org/10.1109/irmmw-thz.2012.6380204.

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