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Letteratura scientifica selezionata sul tema "Furosemide – Stability"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 1 febbraio 2022

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Articoli di riviste sul tema "Furosemide – Stability"

Machado, Ana Isabel, Rita Fragoso, Ana Vitória Martins Neves Barrocas Dordio e Elizabeth Duarte. "Furosemide in water matrix: HPLC-UV method development and degradation studies". Ambiente e Agua - An Interdisciplinary Journal of Applied Science 15, n. 1 (17 febbraio 2020): 1. http://dx.doi.org/10.4136/ambi-agua.2406.

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This study developed a method for furosemide quantification through high performance liquid chromatographic technique. Special attention was given to solute loss and storage stability due to furosemide’s low solubility and photosensitivity, respectively. The performance of Nylon and PVDF filters was tested in a 2 mg.L-1 furosemide solution. PVDF filters showed better recovery capacity and therefore are more suitable for furosemide filtration. Over eight days, three different storage conditions were studied to access furosemide degradation susceptibility: (i) exposure to light at room temperature, (ii) storage at room temperature without exposure to light, and (iii) storage at 4ºC without exposure to light. The study demonstrated that after 48 h under natural light exposure furosemide was completely degraded. Furosemide solution stored in the dark was stable. Storage temperature did not seem to affect furosemide concentration. The study shows that the selection of more suitable filter and storage conditions for furosemide determination is crucial to avoid underestimation errors.

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Elwell, Rowland J., Anne P. Spencer, Julie F. Barnes, James E. Wynn e Curtis E. Jones. "Stability of Furosemide in Human Albumin Solution". Annals of Pharmacotherapy 36, n. 3 (marzo 2002): 423–26. http://dx.doi.org/10.1345/aph.1a232.

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OBJECTIVE: To determine the chemical stability of furosemide in human albumin solution over a 28-day period and to assess admixtures for microbiologic contamination. METHODS: Samples were prepared by mixing furosemide injectable solution and 25% human albumin solution in a 1:1 molar ratio. Six bulk containers were prepared and stored in the dark: 3 under refrigeration (∼4 °C) and 3 at room temperature (∼25 °C). Study samples were withdrawn from each bulk solution immediately after preparation and at predetermined intervals over the subsequent 28 days. Containers were observed for color change and precipitation against a light and dark background at each sampling interval. Total furosemide concentration was determined using HPLC. Additional vials were prepared and assessed for microbiologic growth at time points corresponding with chemical stability results. RESULTS: A mean of 94.5% ± 1.33% of the initial furosemide concentration remained after 48 hours at room temperature. Under refrigeration, 100.6% ± 1.02% of the initial concentration remained at 14 days. Beyond these respective time points, <90% of the initial furosemide concentration remained. No bacterial or fungal growth was observed. CONCLUSIONS: When combined with 25% human albumin solution and stored under darkness, furosemide is chemically stable and free of microbiologic contamination for 48 hours at room temperature and 14 days under refrigeration.

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Hanna, George M., e Cesar A. Lau-Cam. "Stability-Indicating Proton Nuclear Magnetic Resonance Spectroscopic Assay Method for Furosemide in Tablets and Injections". Journal of AOAC INTERNATIONAL 76, n. 3 (1 maggio 1993): 526–30. http://dx.doi.org/10.1093/jaoac/76.3.526.

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Abstract A simple, specific, and accurate proton nuclear magnetic resonance (1H-NMR) spectroscopic method has been developed for the identification and assay of furosemide and its degradation product, 4-chloro-5-sulfamoylanthranilic acid (CSA), in tablets and injections. Dissolution of the sample in D20-NaOD resulted in a solution yielding the required separation among the resonance signals of furosemide, CSA, and ferf-butyl alcohol, the internal standard. The mean ± SD recovery values of furosemide and CSA from 10 synthetic formulations were 99.6 ± 0.8 and 98.9 ± 1.7%, respectively. Commercial tablets (6 lots) and injections (5 lots) of furosemide were assayed by the proposed method and found to contain 53.1-99.8% furosemide and 0.3-45.2% CSA.

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Vlachou, Marilena, Natassa Pippa, Angeliki Siamidi e Aimilia Kyrili. "Thermal analysis studies on the compatibility of furosemide with solid state and liquid crystalline excipients". Chemical Industry 74, n. 1 (2020): 15–23. http://dx.doi.org/10.2298/hemind190910002v.

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In the context of the present study, the thermal behavior of furosemide and the solid state excipients, sodium alginate, poly(ethylene oxide), poly(vinylpyrrolidone), lactose mono-hydrate and magnesium stearate, using Differential Scanning Calorimetry (DSC), was probed. It was found that the thermal behavior of these solid-state pharmaceutical excipients and furosemide correlates nicely with the literature relevant data. Regarding the furosemide-excipients mixtures, the DSC scans appear as a compilation of the thermal curves of each excipient. This suggests that the formulations containing these mixtures, may retain their stability over time. This information, which arises from the cooperativity of materials, their thermal stability and behavioris very helpful for the research and development of safe and effective pharmaceutical formulations. DSC experiments were also carried out with chimeric bilayers (called ?liposomes?), composed of hydrogenated soy phosphatidylcholine (HSPC) and poly(n-butylacrylate)-b-poly(acrylic acid) block copolymer with 70 % content of poly(acrylic acid (PnBA-b-PAA 30/70) with the addition of furosemide at the molar ratio of 9:0.1:1.0 in the system HSPC:PnBA-b-PAA 30/70:furosemide. Chimeric liposomal systems were characterized as ?fluid-like? by their DSC curves, which may be potentially translated as an easy way for release of furosemide from the advanced delivery system.

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Cies, Jeffrey J., Wayne S. Moore, Arun Chopra, Guizhen Lu e Robert W. Mason. "Stability of furosemide and chlorothiazide stored in syringes". American Journal of Health-System Pharmacy 72, n. 24 (15 dicembre 2015): 2182–88. http://dx.doi.org/10.2146/ajhp150023.

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Ram, Rajesh R., Vijay R. Ram e Hitendra S. Joshi. "Analytical Method Validation of Simultaneous Determination of Spironolactone and Furosemide in Tablet Formulation and its Statistical Evaluation". International Letters of Chemistry, Physics and Astronomy 42 (dicembre 2014): 25–35. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.42.25.

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The objective of current study was to Statistical Comparison for Precision and Intermediate Precision study for Analytical Method Validation of Spironolactone and Furosemide in tablet formulation and developed easy, exact and correct isocratic stability indicating reversed phase HPLC assay method and validated for determination of Spironolactone and Furosemide in solid pharmaceutical dosage forms. Isocratic RP-HPLC separation was achieved on an SGE make 150 4.6mm SS Wakosil II 5C18RS 5 μm column (Part Number: 206610 and Serial Number: A01-063) using mobile phase of Acetonitrile- Ammonium acetate buffer (50:50, v/v) at a flow rate of 1.1 ml/min and the detection was carried out at 254 nm using photo-diode array detector. The method was validated for specificity, linearity, precision, accuracy, robustness and solution stability. The method was linear in the drug concentration range of 40-160 µg/ml with a correlation coefficient 0.9977 and 0.9953 for Spironolactone and Furosemide respectively. The precision (RSD) amongst six-sample preparation was 0.87% and 1.1 % for Spironolactone and Furosemide respectively. For repeatability and intermediate precision (RSD) amongst six-sample preparation was 0.46 % and 0.20 % for Spironolactone and Furosemide respectively. As result shown that for furosemide, % RSD was 1.12% and in ANOVA study Significance F value found 0.625502408 and for spironolactone Precision study and Intermediate precision study % RSD was 0.68, in ANOVA study Significance F value found 0.905843808.

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Alfred-Ugbenbo, Deghinmotei, Oleksandr Zdoryk e Viktoria Georgiyants. "Quality assessment and stability study of compounded furosemide syrup". ScienceRise: Pharmaceutical Science, n. 5 (9) (31 ottobre 2017): 28–35. http://dx.doi.org/10.15587/2519-4852.2017.113517.

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Asafu-Adjaye, E. B., A. S. Carlin, E. H. Jefferson, A. R. Bryant, B. Rothman, M. A. Khan e P. J. Faustino. "Comparative stability study of unit-dose repackaged furosemide tablets". Clinical Research and Regulatory Affairs 28, n. 2 (20 aprile 2011): 38–48. http://dx.doi.org/10.3109/10601333.2011.568492.

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Brevedan, Marta I. V., María A. Varillas e Noelia L. Gonzalez Vidal. "Pharmaceutical Equivalence and Stability of Furosemide Tablets in Argentina". Dissolution Technologies 26, n. 4 (novembre 2019): 30–37. http://dx.doi.org/10.14227/dt260419p30.

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Shaik, Javed S., e Nutan N. Rao. "SIMULTANEOUS ESTIMATION AND FORCED DEGRADATION STUDIES OF AMILORIDE HYDROCHLORIDE AND FUROSEMIDE IN A PHARMACEUTICAL DOSAGE FORM USING REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD". Asian Journal of Pharmaceutical and Clinical Research 11, n. 7 (7 luglio 2018): 215. http://dx.doi.org/10.22159/ajpcr.2018.v11i7.25783.

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Abstract (sommario):

Objective: The present study describes the stability indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method for simultaneous estimation of amiloride hydrochloride and furosemide in pharmaceutical dosage forms.Methods: The proposed RP-HPLC method was developed using Shimadzu LC-2030 HPLC system equipped with UV detector, and chromatographic separation was carried on Shim-pack C18 (250 mm×4.6 mm, 5 μ) column at a flow rate of 1 ml/min and the runtime was 4min. The mobile phase consisted of water and acetonitrile in the ratio of 35:65, and elements were scanned using a UV detector at 281 nm.Results: The retention time of amiloride hydrochloride and furosemide was found to be 1.92 min and 3.14min, respectively. Linearity was found to be 12–28 ppm for amiloride hydrochloride and 96–224 ppm for furosemide, respectively. Limit of detection and limit of quantification for amiloride hydrochloride were 0.381 ppm and 1.156 ppm and for furosemide were 2.00 ppm and 6.068 ppm, respectively.Conclusion: The stability indicating method was developed by subjecting the drugs to stress conditions such as acid and base hydrolysis, oxidation, humidity, photolytic, and thermal degradation, and the degraded products formed were resolved successfully from the samples.

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Più fonti

Tesi sul tema "Furosemide – Stability"

Melane, Babalwa Blossom. "Thermal and photostability studies of furosemide and its cyclodextrin mixtures". Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1007625.

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Abstract (sommario):

Furosemide (Lasix®), abbreviated as FR and also known as frusemide, is a drug used for renal problems and treatment of cardiac edema. Various polymorphic forms of furosemide, dependent upon the method of preparation and thermal treatment, have been reported. The main thermal decomposition product of furosemide has been identified as saluamine. The dissolution properties of furosemide have also been reported to be improved by complexation with beta-cyclodextrin. Photostabilities of the different crystal forms have been studied. Differential scanning calorimetry (DSC) and thermogravimetry (TG) have been used to examine the thermal behaviour of furosemide itself and of its physical and kneaded mixtures with betacyclodextrin (BCD) and gamma-cyclodextrin (GCD). There is strong evidence from DSC that complex formation between FR and GCD occurs. This is supported by IR and XRD data. Decreases in the intensity and broadening of the characteristic carbonyl (1660 cm'l) and amine (1588 cm⁻¹) bands in the kneaded mixture, compared to the physical mixture, were observed with IR. X-ray diffraction results for the 1:3 molar ratio FR/GCD kneaded mixture showed a halo diffraction pattern characteristic. of an amorphous solid and did not resemble patterns from the drug, or the gamma, cyclodextrin, or the physical mixture. Photostability studies have been conducted on solid furosemide and its mixtures with GCD or BCD. An HPLC method was developed to determine the amount of drug remaining after exposure and the presence of any degradants. Results indicated that about 10% degradation of the drug occurred during exposure for 16 hours at 550 W/m², with the appearance of polar degradants. Although IR and DSC results for the 1:3 molar ratio FR/GCD kneaded mixture showed a probable strong interaction between FR and GCD, the photostability of FR was decreased. The 1 :3 molar ratio FR/BCD kneaded mixture showed less photo-degradation than the 1:3 molar ratio FR/GCD mixture under similar conditions, suggesting that inclusion of the drug molecule (FR) is different in the two cyclodextrins.

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Capitoli di libri sul tema "Furosemide – Stability"

"Furosemide". In Extended Stability for Parenteral Drugs, 197–98. American Society of Health-System Pharmacists, 2017. http://dx.doi.org/10.37573/9781585285280.087.

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"Famciclovir – Furosemide". In Trissel’s Stability of Compounded Formulations, 6e. 2215 Constitution Avenue, N.W. Washington, DC 20037-2985: The American Pharmacists Association, 2018. http://dx.doi.org/10.21019/9781582122960.f.

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Atti di convegni sul tema "Furosemide – Stability"

Chentoufi, M. Alami, S. Bennis, M. Benabbes, A. Cheikh, H. Meftah, A. Zahidi, Mould Bouyahya Idrissi, M. Draoui e M. Bouatia. "3PC-009 Physicochemical stability of intravenous injection of a generic product of furosemide prepared in polypropylene syringes". In Abstract Book, 23rd EAHP Congress, 21st–23rd March 2018, Gothenburg, Sweden. British Medical Journal Publishing Group, 2018. http://dx.doi.org/10.1136/ejhpharm-2018-eahpconf.61.

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