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Tesi sul tema "Gemfibrozilo"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 6 febbraio 2022

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1

Breña, Figueroa Mirtha Rocío. "Diseño y desarrollo de una formulación para Gemfibrozilo 600 mg. tableta recubierta." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2005. https://hdl.handle.net/20.500.12672/2603.

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Abstract (sommario):
En el presente trabajo se han evaluado tres formulaciones para Gemfibrozilo 600 mg tableta recubierta, una realizada por compresión directa y dos por granulación húmeda, de las cuales se ha seleccionado a la formulación que cumple los parámetros establecidos para el dosaje, disolución y los factores de deferencia (F1) y similitud (F2), estos factores fueron determinados a través de la comparación por perfil de disolución con respecto al producto innovador. Se realizó el estudio de estabilidad acelerada (40ºC ± 2 ºC / 75% de humedad relativa ± 5%.), estabilidad a largo plazo (25 ºC ± 2 ºC / 60
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2

Maguiña, Cacha Elbis Jhon, and Verástegui Diocelino Fernando Nuevo. "Análisis costo-efectividad del uso de estatinas frente a gemfibrozilo en pacientes de consultorios externos del Centro Médico Naval : Cirujano Mayor Santiago Távara." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2006. https://hdl.handle.net/20.500.12672/2326.

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Abstract (sommario):
El presente es un estudio transversal, descriptivo y retrospectivo realizado en el Centro Médico Naval “Santiago Távara”, ubicado en Av. Venezuela s/n Bellavista-Callao, con el objetivo de determinar y comparar el costo-efectividad de Estatinas (Atorvastatina 20mg y Pravastatina 20 mg) frente a Gemfibrozilo 600 mg en el tratamiento de hiperlipidemia durante el período de enero 2002 a julio 2005. Se revisaron las historias clínicas de 64 pacientes hiperlipidémicos, con edades entre los 40 y 64 años de ambos sexos que acuden a los consultorios externos de Cardiología, Endocrinología, Geriatría y
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3

Hemingway, Cheryl Joy. "Investigation of the molecular mechanisms of inhibition of hepatic fatty acid and cholestral biosynthesis by hypolipidaemic agents." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285489.

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4

Chamouret, Sandrine. "Le gemfibrozil : étiologie possible de pneumopathies médicamenteuses : à propos de deux cas." Saint-Etienne, 1995. http://www.theses.fr/1995STET6222.

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5

Prindiville, John S. "Circulating lipoproteins and tissue lipids: Effects of gemfibrozil on lipid metabolism in rainbow trout." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28555.

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Abstract (sommario):
Lipids support crucial functions in teleost fish, including the production of energy; lipoproteins support the movement of lipids through the vascular system. The objective of this thesis was to determine if gemfibrozil (GEM), a mammalian PPARalpha agonist pharmaceutical, could alter the circulating lipoproteins and tissue lipid metabolism in the rainbow trout, Oncorhynchus mykiss. Injections of GEM lowered the concentration of lipoproteins and changed their size distribution, lipid and fatty acid content. These changes were associated with an increased lipoprotein lipase transcript level but
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6

Santos, Tiago André Azevedo dos. "Fish personality, memory and learning hability: the effect of pharmaceuticals and abiotic factors." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22023.

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Abstract (sommario):
Mestrado em Biologia Molecular e Celular<br>Over the last years, animal personality has been gaining a lot of attention from the scientific community, and, at the moment, it is being questioned its importance in survival and the evolution of species in stress situation. Between all of potential stress agents, there are emerging environmental contaminants, such as, pharmaceuticals. However, there are not many behavior and personality studies in fish. The present work aims to increase the knowledge of how factors associated with personality can influence the response to pharmaceuticals detected
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7

Filho, José Joaquim Fernandes Raposo. "Suco de laranja tem efeito sinérgico à estatina e ao genfibrozila no tratamento da aterosclerose." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-22092010-162733/.

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Abstract (sommario):
FUNDAMENTO: O suco de laranja (Citrus sinensis) é rico em vitami-na C, folatos e seu principal flavonóide, a hesperidina, cuja conformação es-pacial é semelhante à genisteína de soja que tem ação favorável sobre o aparelho cardiovascular. A vitamina C é conhecida como potente inibidor da peroxidação lipídica. Mas sua capacidade por possuir efeitos terapêuticos no tratamento da aterosclerose é pouco estudada. OBJETIVO: O presente tra-balho visa a determinar se o suco de laranja pode ter efeito aditivo no trata-mento com estatinas e fibratos, reduzindo placas ateroscleróticas e a quanti-dade de
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8

Laser, Eric [Verfasser], Olaf [Gutachter] Picker, and Georg [Gutachter] Flügen. "Der Einfluss von Gemfibrozil und Pravastatin auf die mitochondriale Funktion im Colon und in der Leber in vitro - Ein Therapieansatz bei Sepsis? / Eric Laser ; Gutachter: Olaf Picker, Georg Flügen." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1230135111/34.

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9

Bergman, Ebba. "The Hepatobiliary Transport of Rosuvastatin In Vivo." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109866.

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Abstract (sommario):
In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. The research included in this thesis has focused on the involvement of hepatic transport proteins in the hepatobiliary disposition of rosuvastatin. The impact that several transport inhibitors had on the pharmacokinetics of rosuvastatin was investigated
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10

Dah-Chung, Owe Yang, and 歐陽大中. "The Synthesis of Gemfibrozil." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/75834394951751380638.

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碩士<br>國立成功大學<br>化學工程研究所<br>82<br>2,2-dimethyl-5(2,5-xylyloxy) valeric acid, known as gemfibrozil, and used for treatment or prevention of arteriosclerosis, can be produced by these ways: (1) Abstraction of proton from Me2CHCOPh using NaNH2 followed by alkylation with Br(CH2)3Cl resulted in Cl(CH2)3CMe2COPh(b). Refluxing b with anhydrous K2CO3,KI and 2,5-xylenol in a medium polar solvent gave 2,5-Me2C6H3O(CH2)3CMe2COPh. The latter was heated with KOCMe3 in anisole to yield gemfibrozil. The r
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11

Ke, Kai De, and 柯開德. "Study on the synthesis of hypolipoproteinemic agent gemfibrozil." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/40398412301635033522.

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12

Ker, Kai-Der, and 柯開德. "1.Study on Synthesis of Hypolipoproteinemic Agent Gemfibrozil." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/88108221674407079088.

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Abstract (sommario):
碩士<br>國立臺灣大學<br>藥學研究所<br>82<br>Part I: A novel synthetic scheme for preparation of hypolipoprot einemic agent,gemfibrozil,is proposed.In this study using p-xyle ne and 2,5-dimethylphenol as starting materials.The significance of the synthetic process is to produce gemfibrozil end product along with 2,5-dimethylphenol, a starting material for use in the next synthetic process of gemfibrozil. Part II: Designed and synthesis a series of 2,4-diamino-6-hydroxy 5-(1-substituted-4-piperidinyl)-
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13

YE, JING-JING, та 葉菁菁. "Gemfibrozil葉效藥劑學之研究". Thesis, 1991. http://ndltd.ncl.edu.tw/handle/75911352297005536743.

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碩士<br>國立臺灣大學<br>藥學研究所<br>79<br>Gemfibrozil 是一種血脂調節劑，結構上類似clofibrate，同是屬於fibric acid 的 衍生物。Gemfibrozil 可有效地降低血中三酸甘油酯的濃度，並增加高密度脂蛋白的 濃度；因此gemfibrozil 常被用來治療嚴重的高血脂症，以及降低因血脂異常而導致 冠狀動脈性心臟病的發生率。 胡研究指出，市面上不同配方的藥物產品對於其吸收曲線的形態有不同的影響。因此 ，本實驗即針對製劑上幾個配方因素進行研究，希望找出可能造成體內吸收差異的因 素。實驗內容主要包括體外溶離試驗，熱掃描分析試驗，以及體內吸收試驗。 影響固體劑型的釋出和吸收的因素有很多，例如：原料顆粒的大小，稀釋劑，潤滑劑 ，崩散劑及界面活性劑等。在體外溶離試驗中，乳糖、澱粉、硬脂酸、硬脂酸鎂及月 桂基硫酸鈉被採用來測試添加不同的賦形劑可能造成的影響；且藥品顆粒大小所造成 的影響亦被測試之。實驗結果顯示在不加酵素的人工腸液中，乳糖、澱粉、月桂基硫
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14

Chen, Yi-Yen, and 陳怡晏. "Effectiveness of Repaglinide-Gemfibrozil Interaction Alert in a Medical Center." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/38444993918405916470.

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Abstract (sommario):
碩士<br>國立陽明大學<br>藥理學研究所<br>104<br>Background: Drug-drug interaction (DDI) is defined as the change of pharmacodynamics or pharmacokinetics of a drug by prior administration or coadministration of another drug. DDI may cause adverse drug events (ADEs). The computerized drug-interaction alert system (DIAS) may reduce the occurrence of DDIs. Contraindicated repaglinide and gemfibrozil interaction alert was implemented in DIAS at a medical center since 2004. When physicians issued the prescriptions with both repaglinide and gemfibrozil, the alert automatically popped out the warning details: “gemfi
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15

Krkosek, Wendy Helen. "REMOVAL AND TRANSFORMATION OF GEMFIBROZIL, A PHARMACEUTICALLY ACTIVE COMPOUND, IN WASTEWATER TREATMENT." 2013. http://hdl.handle.net/10222/44169.

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Pharmaceutically active compounds (PhACs) have been found in wastewater effluents and receiving waters around the world. As yet there are no jurisdictions that regulate their release, or their impact on receiving water ecosystem health. The issue is complex due to the number of PhACs that exist, the variability in their structure and function, the variability in removal during different wastewater treatment processes, the potential for formation of metabolites and transformation products, and a lack of information on the impacts due to their presence on receiving waters. Gemfibrozil is a lipid
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16

Lin, Pai-Ching, and 林柏青. "Micronization of Gemfibrozil, Lidocaine, Ethosuximide and Tolbutamide by Rapid Expansion Supercritical Technique." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/23927696591114881104.

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碩士<br>國立臺灣大學<br>化學工程學研究所<br>96<br>The particle sizes of the pharmaceutical substances are important for their bioavailability, which can be improved by size reduction. In this study, Gemfibrozil, Lidocaine, and Ethosuximide were micronized using the rapid expansion of supercritical solution (RESS) technique. It is found that Gemfibrozil were heterogeneous under certain operational conditions of the RESS process. This phenomenon was explained by phase equilibrium theory. Under modified conditions, the dispersible and micronized gemfibrozil particles were successfully obtained. The effects of ex
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17

Lin, Yi-Sheng, and 林益生. "Trends in Ambulatory Prescription of Potential Drug-Drug Interaction: Gemfibrozil-Repaglinide Co-medication as An Example." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/80605108145374867261.

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Abstract (sommario):
碩士<br>國立陽明大學<br>藥理學研究所<br>104<br>Background: Gemfibrozil, a lipid lowering agent belonging to the fibric acid derivates, is a strong cytochrome P450 2C8 (CYP2C8) inhibitor. Repaglinide, an oral antidiabetic drug belonging to meglitinides category, is metabolized by CYP2C8 and CYP3A4. Recent studies indicated that concomitant use of gemfibrozil and repaglinide would markedly enhanced and prolonged the blood glucose-lowering effect of repaglinide, and might increase risk of severe hypoglycemia, a life-threatening adverse effect. Therefore, in 2003 the Ministry of Health and Welfare in Taiwan ann
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18

"Qualitative and quantitative changes in serum lipid profile of patients with combined hyperlipidaemia on combination therapy with fluvastatin and gemfibrozil." 1998. http://library.cuhk.edu.hk/record=b5889810.

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Abstract (sommario):
by Lee Hon Kit.<br>Thesis (M.Sc.)--Chinese University of Hong Kong, 1998.<br>Includes bibliographical references (leaves 80-89).<br>Chapter 1. --- Introduction --- p.1<br>Chapter 1.1 --- Lipids and Lipoproteins --- p.1<br>Chapter 1.1.1 --- Chemistry and Classification of Lipids --- p.1<br>Chapter 1.1.2 --- Lipoprotein and Apolipoprotein --- p.3<br>Chapter 1.1.2.1 --- Lipoprotein: Structure and Classification --- p.3<br>Chapter 1.1.2.2 --- Apolipoprotein: Structure and Function --- p.5<br>Chapter 1.1.2.3 --- Lipoprotein (a) and Apolipoprotein (a) --- p.8<br>Chapter 1.1.3 --- Outline of L
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19

Lee, On, and 李昂. "I. Study on the Synthesis and Hypocholesteremic Activities of Gemfibrozil Analogues. II. Study on the Synthesis and Antitumor Activities of Pyrimidine and Azatyrosine Analogues." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/50063398551951211969.

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Abstract (sommario):
博士<br>國立臺灣大學<br>藥學系<br>85<br>This thesis containe three parts, which are (1) study on the synthesis and hypocholesteremic activities of gemfibrozil analogues , (2) design and synthesis of novel kcat type dihydrofolate reductase inhibitors and (3) study on the synthesis and cell growth inhibition of azatyrosine analogues.In the first part, a novel process for the synthesis of gemfibrozil was developed. The avoidance of using strong bases in the new process lowers the complexity and increases
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20

Crosina, Quinn Kathleen. "A Bench-scale Evaluation of the Removal of Selected Pharmaceuticals and Personal Care Products by UV and UV/H₂O₂ in Drinking Water Treatment." Thesis, 2006. http://hdl.handle.net/10012/2632.

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Abstract (sommario):
A bench-scale study of the degradation of four selected pharmaceuticals and personal care products (PPCPs) was carried out using UV and UV/H₂O₂ treatment employing low pressure (LP) and medium pressure (MP) lamps. The target substances included the pharmaceutical compounds ibuprofen, naproxen, and gemfibrozil, along with the bactericide triclosan. There were four main objectives of the study, as follows: to evaluate the removal of the target compounds using UV irradiation alone and UV/H₂O₂, to determine the reaction kinetics for direct and indirect photolysis of each selected compound, to det
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21

Barreto, Ângela Maria Almeida. "Effects of gold nanoparticles on Sparus aurata." Doctoral thesis, 2018. http://hdl.handle.net/10773/26081.

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Abstract (sommario):
Estuarine and coastal areas are the ultimate recipient for most contaminants, including emerging contaminants of concern such as nanoparticles (NPs) and pharmaceuticals. Gold nanoparticles (AuNPs) are used for a wide range of applications and have the potential to be extensively released into the environment. One of the fundamental requirements for the wide use of AuNPs is their presumed non-toxic and biocompatible nature, but recent studies have highlighted their possible toxicity, including oxidative stress, genotoxicity and protein modifications. These findings raise concerns about the pote
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22

Hoose, Scott Allen. "Systematic Analysis of Genetic and Pharmaceutical Modulators of the Eukaryotic Cell Cycle." Thesis, 2012. http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11777.

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Abstract (sommario):
Cell replication and division are central to the proliferation of life, and have implications for normal growth and development as well as disease state. Assembly of a complete picture of the systems which control this process requires identification of individual genetic components, but the identity and complete sequence of events that trigger initiation of cell division, at a point called START in yeast, remain unknown. Here, we evaluated panels of non-essential single gene deletion strains and tested the effects of FDA-approved drugs on cell-cycle progression, using flow cytometry to detect
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