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Articoli di riviste sul tema "Gene Expression RNA, Messenger"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 3 febbraio 2022

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1

Bøe, Sigurd, Stein Sæbøe-Larssen, and Eivind Hovig. "Light-Induced Gene Expression Using Messenger RNA Molecules." Oligonucleotides 20, no. 1 (2010): 1–6. http://dx.doi.org/10.1089/oli.2009.0209.

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2

Frye, Michaela, Bryan T. Harada, Mikaela Behm, and Chuan He. "RNA modifications modulate gene expression during development." Science 361, no. 6409 (2018): 1346–49. http://dx.doi.org/10.1126/science.aau1646.

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Abstract (sommario):

RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example,N6-methyladenosine (m6A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications

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3

Zhang, Jing, Fanghui Ding, Dan Jiao, Qiaozhi Li, and Hong Ma. "The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382091733. http://dx.doi.org/10.1177/1533033820917332.

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RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients with various types of cancer. Although gastric cancer is a relatively frequent and potentially fatal malignancy, the mechanism by which insulin-like growth factor 2 messenger RNA–binding protein 3 regulates the development of this cancer remains unclear. This study aimed to investigate the role and regulatory mechanism of insulin-like growth facto

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4

Weil, D., S. Brosset, and F. Dautry. "RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2." Molecular and Cellular Biology 10, no. 11 (1990): 5865–75. http://dx.doi.org/10.1128/mcb.10.11.5865.

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We have previously reported that tumor necrosis factor beta (TNF beta) expression is induced by interleukin-2 (IL-2) in the murine lymphocytic T-cell line CTLL-2. In this study, we have characterized the nuclear and cytoplasmic TNF beta transcript and assessed their role in TNF beta gene expression. A unique feature of TNF beta expression was the accumulation of nuclear precursors, which reflected a slow nuclear RNA processing. As a consequence, there was a delay in the appearance of cytoplasmic messengers after the transcriptional induction of TNF beta by IL-2. We also found that two messenge

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Weil, D., S. Brosset, and F. Dautry. "RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2." Molecular and Cellular Biology 10, no. 11 (1990): 5865–75. http://dx.doi.org/10.1128/mcb.10.11.5865-5875.1990.

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We have previously reported that tumor necrosis factor beta (TNF beta) expression is induced by interleukin-2 (IL-2) in the murine lymphocytic T-cell line CTLL-2. In this study, we have characterized the nuclear and cytoplasmic TNF beta transcript and assessed their role in TNF beta gene expression. A unique feature of TNF beta expression was the accumulation of nuclear precursors, which reflected a slow nuclear RNA processing. As a consequence, there was a delay in the appearance of cytoplasmic messengers after the transcriptional induction of TNF beta by IL-2. We also found that two messenge

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6

Lei, Sibei, Xueyan Zhang, Jingmei Li, et al. "Current Progress in Messenger RNA-Based Gene Therapy." Journal of Biomedical Nanotechnology 16, no. 7 (2020): 1018–44. http://dx.doi.org/10.1166/jbn.2020.2961.

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Based on its rapid expression, simple sequence composition, low immunogenicity, and flexible modification possibilities, in vitro synthesized mRNA has demonstrated strong potential as a candidate for gene therapy. Many efforts have been made to enhance its therapeutic efficacy and safety. Profiting from the development in pathogenesis and materials science, much progress has been achieved in mRNA-based therapy studies. Many mRNA-derived therapeutics including vaccines, antibodies, cytokines, and growth factors have emerged for the treatment of diverse diseases that have multiple modes of actio

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7

Fioravanti, Antonella, Luigi Pirtoli, Antonio Giordano, and Francesco Dotta. "Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology." International Journal of Molecular Sciences 21, no. 4 (2020): 1270. http://dx.doi.org/10.3390/ijms21041270.

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8

Barrow, L., M. S. Tanner, and D. R. Critchley. "Expression of the Caeruloplasmin Gene in the Adult and Neonatal Rat Liver." Clinical Science 77, no. 3 (1989): 259–63. http://dx.doi.org/10.1042/cs0770259.

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1. It has been suggested that low levels of serum caeruloplasmin in Wilson's disease result from the failure to switch from a fetal to an adult mode of caeruloplasmin gene expression. To investigate postnatal expression of the caeruloplasmin gene, steady-state levels of caeruloplasmin messenger RNA in adult and neonatal rat liver were measured. 2. Copper parameters observed in neonatal rats were similar to those seen in Wilson's disease: hepatic copper concentration was significantly elevated (neonatal 164 ± 35 μg/g, adults 50 ± 8 μg/g, P < .001) and serum copper and caeruloplasmin levels w

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9

Carrier, T. A., and J. D. Keasling. "Controlling Messenger RNA Stability in Bacteria: Strategies for Engineering Gene Expression." Biotechnology Progress 13, no. 6 (1997): 699–708. http://dx.doi.org/10.1021/bp970095h.

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10

Straub, Bernd, Markus Müller, Hans Krause, Mark Schrader, Carsten Goessl, and Kurt Miller. "Receptor Gene Messenger RNA Expression in Metastatic Lesions of Prostate Cancer." Journal of Urology 168, no. 3 (2002): 1212–14. http://dx.doi.org/10.1016/s0022-5347(05)64627-7.

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11

Sasaki, Hidefumi, Hiroshi Haneda, Haruhiro Yukiue, Yoshihiro Kobayashi, Motoki Yano, and Yoshitaka Fujii. "Decreased Fragile Histidine Triad Gene Messenger RNA Expression in Lung Cancer." Clinical Lung Cancer 7, no. 6 (2006): 412–16. http://dx.doi.org/10.3816/clc.2006.n.026.

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12

Eastwood, Sharon L., Nigel J. Cairns, and Paul J. Harrison. "Synaptophysin gene expression in schizophrenia." British Journal of Psychiatry 176, no. 3 (2000): 236–42. http://dx.doi.org/10.1192/bjp.176.3.236.

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BackgroundDecreased expression of proteins such as synaptophysin in the hippocampus and prefrontal cortex in schizophrenia is suggestive of synaptic pathology. However, the overall profile of changes is unclear.AimsTo investigate synaptophysin gene expression in the cerebral cortex in schizophrenia.MethodThe dorsolateral prefrontal (Brodmann area [BA] 9/46), anterior cingulate (BA 24), superior temporal (BA 22) and occipital (BA 17) cortex were studied in two series of brains, totalling 19 cases and 19 controls. Synaptophysin was measured by immunoautoradiography and immunoblotting. Synaptophy

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13

Goldmann, Wilfred, Gerard O’Neill, Foo Cheung, Fiona Charleson, Peter Ford, and Nora Hunter. "PrP (prion) gene expression in sheep may be modulated by alternative polyadenylation of its messenger RNA." Journal of General Virology 80, no. 8 (1999): 2275–83. http://dx.doi.org/10.1099/0022-1317-80-8-2275.

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Scrapie-associated fibrils and their major protein component, PrP or prion protein, accumulate in the brains and some other tissues of all species affected by transmissible spongiform encephalopathies or prion diseases. To investigate the role of PrP gene expression in the hosts of these diseases, we have analysed some characteristics of PrP gene RNA transcripts in sheep and cattle tissues and made comparisons with PrP RNA transcripts in human and mouse tissues. Two PrP messenger RNAs of 4·6 kb and 2·1 kb, the result of alternative polyadenylation, were found first in sheep peripheral tissues

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Charlton, S. T., B. J. Cameron, D. R. Glimm, G. R. Foxcroft, and J. J. Kennelly. "Insulin-like growth factor 1 (IGF-1) gene expression in porcine ovarian tissue." Canadian Journal of Animal Science 73, no. 2 (1993): 253–57. http://dx.doi.org/10.4141/cjas93-027.

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A study was conducted to demonstrate IGF-1 gene expression in porcine ovarian tissue. Using northern blot analysis, IGF-1 messenger ribonucleic acid (mRNA) transcripts could not be consistently detected in total RNA. Authentic mRNA transcripts were detected in polyadenylated RNA-enriched RNA with sizes of 8.0, 3.6 and 2.3 bases, and possibly 0.8–1.1 kbases. Key words: Ovary, IGF-1, pig, mRNA

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15

Lichtor, Terry, George J. Dohrmann, and Mark E. Gurney. "Cytokine Gene Expression by Human Gliomas." Neurosurgery 26, no. 5 (1990): 788–93. http://dx.doi.org/10.1227/00006123-199005000-00009.

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Abstract Two glioma tumor lines and specimens from five patients with gliomas were analyzed to determine genic expression of four growth factors found in human brain. Messenger RNA encoding for interleukin-1β, interleukin-6, and basic fibroblast growth factor was found to be expressed in significant amounts in some of these tumors, while mRNA for interleukin-3 was found in small quantities in only the tumor lines. Multiple species of mRNA for basic fibroblast growth factor were found. Expression of growth factor genes may play a role in the growth of human gliomas.

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16

Smith, James R., and Olivia M. Pereira-Smith. "Altered gene expression during cellular aging." Genome 31, no. 1 (1989): 386–89. http://dx.doi.org/10.1139/g89-058.

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The limited division potential of normal human diploid fibroblasts in culture represents a model system for cellular aging. Observations indicate cellular senescence is an active process. Senescent cells, although unable to divide, are actively metabolizing. Hybrids from fusion of normal and immortal human cells exhibit limited division potential, suggesting that the phenotype of cellular senescence is dominant and supporting the hypothesis that senescence is genetically programmed. Fusion of immortal human cell lines with each other has identified four complementation groups for indefinite di

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17

Licht, Konstantin, and Michael F. Jantsch. "Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications." Journal of Cell Biology 213, no. 1 (2016): 15–22. http://dx.doi.org/10.1083/jcb.201511041.

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Advances in next-generation sequencing and mass spectrometry have revealed widespread messenger RNA modifications and RNA editing, with dramatic effects on mammalian transcriptomes. Factors introducing, deleting, or interpreting specific modifications have been identified, and analogous with epigenetic terminology, have been designated “writers,” “erasers,” and “readers.” Such modifications in the transcriptome are referred to as epitranscriptomic changes and represent a fascinating new layer of gene expression regulation that has only recently been appreciated. Here, we outline how RNA editin

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18

Rahman, Rayees, Nicole Zatorski, Jens Hansen, et al. "Protein structure–based gene expression signatures." Proceedings of the National Academy of Sciences 118, no. 19 (2021): e2014866118. http://dx.doi.org/10.1073/pnas.2014866118.

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Gene expression signatures (GES) connect phenotypes to differential messenger RNA (mRNA) expression of genes, providing a powerful approach to define cellular identity, function, and the effects of perturbations. The use of GES has suffered from vague assessment criteria and limited reproducibility. Because the structure of proteins defines the functional capability of genes, we hypothesized that enrichment of structural features could be a generalizable representation of gene sets. We derive structural gene expression signatures (sGES) using features from multiple levels of protein structure

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De Gaudenzi, Javier G., Griselda Noé, Vanina A. Campo, Alberto C. Frasch, and Alejandro Cassola. "Gene expression regulation in trypanosomatids." Essays in Biochemistry 51 (October 24, 2011): 31–46. http://dx.doi.org/10.1042/bse0510031.

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Trypanosomatids are protozoan micro-organisms that cause serious health problems in humans and domestic animals. In addition to their medical relevance, these pathogens have novel biological structures and processes. From nuclear DNA transcription to mRNA translation, trypanosomes use unusual mechanisms to control gene expression. For example, transcription by RNAPII (RNA polymerase II) is polycistronic, and only a few transcription initiation sites have been identified so far. The sequences present in the polycistronic units code for proteins having unrelated functions, that is, not involved

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Anderson, Paul, and Nancy Kedersha. "RNA granules." Journal of Cell Biology 172, no. 6 (2006): 803–8. http://dx.doi.org/10.1083/jcb.200512082.

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Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. RNA granules contain various ribosomal subunits, translation factors, decay enzymes, helicases, scaffold proteins, and RNA-binding proteins, and they control the localization, stability, and translation of their RNA cargo. We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger

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21

Anderson, Kelsi L., and Paul M. Dunman. "Messenger RNA Turnover Processes inEscherichia coli, Bacillus subtilis, and Emerging Studies inStaphylococcus aureus." International Journal of Microbiology 2009 (2009): 1–15. http://dx.doi.org/10.1155/2009/525491.

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The regulation of mRNA turnover is a recently appreciated phenomenon by which bacteria modulate gene expression. This review outlines the mechanisms by which three major classes of bacterialtrans-acting factors, ribonucleases (RNases), RNA binding proteins, and small noncoding RNAs (sRNA), regulate the transcript stability and protein production of target genes. Because the mechanisms of RNA decay and maturation are best characterized inEscherichia coli, the majority of this review will focus on how these factors modulate mRNA stability in this organism. However, we also address the effects of

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Peng, Ziqi, Boyang Xu, and Feng Jin. "Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382092847. http://dx.doi.org/10.1177/1533033820928471.

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This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer. The circular RNA expression microarray “GSE101123” related to breast cancer was downloaded from the Gene Expression Omnibus database. The differentially expressed circular RNAs between tumor and normal samples were screened using Limma package. The targeted microRNAs of the differentially expressed circular RNAs and the targeted messenger RNAs of the microRNAs were predicted using miRanda and miRWalk, respectively, and a circular

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Zhang, Quanwei, Qi Wang, Yong Zhang, et al. "Comprehensive Analysis of MicroRNA–Messenger RNA from White Yak Testis Reveals the Differentially Expressed Molecules Involved in Development and Reproduction." International Journal of Molecular Sciences 19, no. 10 (2018): 3083. http://dx.doi.org/10.3390/ijms19103083.

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Testis development is a vital and tightly regulated process in mammals. Understanding the biological mechanisms underlying testis development will benefit the animal reproduction industry. Expression changes in microRNA and messenger RNA in response to dynamic regulation effects have been associated with this process. However, very little is known about the roles of these molecules in yak development. Using whole-genome small RNA and messenger RNA sequencing, we performed a comprehensive analysis of the microRNA–messenger RNA interaction network expression in the testicles of Tianzhu white yak

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Saikia, Snigdha, Asad Ur Rehman, Prajjalendra Barooah, et al. "Alteration in the expression of MGMT and RUNX3 due to non-CpG promoter methylation and their correlation with different risk factors in esophageal cancer patients." Tumor Biology 39, no. 5 (2017): 101042831770163. http://dx.doi.org/10.1177/1010428317701630.

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Promoter methylation reflects in the inactivation of different genes like O6-methylguanine-DNA methyltransferase DNA repair gene and runt-related transcription factor 3, a known tumor suppressor gene in various cancers such as esophageal cancer. The promoter methylation was evaluated for O6-methylguanine-DNA methyltransferase and runt-related transcription factor 3 in CpG, CHH, and CHG context (where H is A, T, or C) by next-generation sequencing. The methylation status was correlated with quantitative messenger RNA expression. In addition, messenger RNA expression was correlated with differen

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López de Silanes, Isabel, María Paz Quesada, and Manel Esteller. "Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer." Analytical Cellular Pathology 29, no. 1 (2007): 1–17. http://dx.doi.org/10.1155/2007/586139.

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The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enha

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Hesketh, John E., M. Helena Vasconcelos, and Giovanna Bermano. "Regulatory signals in messenger RNA: determinants of nutrient–gene interaction and metabolic compartmentation." British Journal of Nutrition 80, no. 4 (1998): 307–21. http://dx.doi.org/10.1017/s0007114598001378.

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Nutrition has marked influences on gene expression and an understanding of the interaction between nutrients and gene expression is important in order to provide a basis for determining the nutritional requirements on an individual basis. The effects of nutrition can be exerted at many stages between transcription of the genetic sequence and production of a functional protein. This review focuses on the role of post-transcriptional control, particularly mRNA stability, translation and localization, in the interactions of nutrients with gene expression. The effects of both macronutrients and mi

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Prescott, James L., and Donald J. Tindall. "Clathrin Gene Expression Is Androgen Regulated in the Prostate*." Endocrinology 139, no. 4 (1998): 2111–19. http://dx.doi.org/10.1210/endo.139.4.5926.

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Abstract Androgens are required for the development and function of the prostate. In a normal human prostate, androgens control the synthesis of proteins such as prostate-specific antigen and human glandular kallikrein. The prostate secretes these proteins as well as a number of other compounds to form the prostatic fluid. Using differential display PCR to detect novel androgen-regulated genes, clathrin heavy chain expression was identified as potentially being up-regulated by androgens in the prostate cancer cell line LNCaP. We report here that the clathrin heavy chain and light chain genes a

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Liu, Tao, Guoru Zhang, Yaling Wang, et al. "Identification of Circular RNA-MicroRNA-Messenger RNA Regulatory Network in Atrial Fibrillation by Integrated Analysis." BioMed Research International 2020 (September 29, 2020): 1–13. http://dx.doi.org/10.1155/2020/8037273.

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Background. Circular RNA (circRNA) is a noncoding RNA that forms a closed-loop structure, and its abnormal expression may cause disease. We aimed to find potential network for circRNA-related competitive endogenous RNA (ceRNA) in atrial fibrillation (AF). Methods. The circRNA, miRNA, and mRNA expression profiles in the heart tissue from AF patients were retrieved from the Gene Expression Omnibus database and analyzed comprehensively. Differentially expressed circRNAs (DEcircRNAs), differentially expressed miRNAs (DEmiRNAs), and differentially expressed mRNAs (DEmRNAs) were identified, followed

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Yamaoka, Y., M. Kita, T. Kodama, N. Sawai, and J. Imanishi. "Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa." Gastroenterology 110, no. 6 (1996): 1744–52. http://dx.doi.org/10.1053/gast.1996.v110.pm8964399.

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Rostoks, Nils, Brian J. Steffenson, and Andris Kleinhofs. "Structure and expression of the barley stem rust resistance gene Rpg1 messenger RNA." Physiological and Molecular Plant Pathology 64, no. 2 (2004): 91–101. http://dx.doi.org/10.1016/j.pmpp.2004.05.006.

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Ogawa, Kazuhiko, Tohru Utsunomiya, Koshi Mimori, et al. "Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal Cancer." Clinical Cancer Research 11, no. 8 (2005): 2889–93. http://dx.doi.org/10.1158/1078-0432.ccr-04-2281.

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Wild, Gary E., Patrizia Papalia, Mark J. Ropeleski, Julio Faria, and Alan BR Thomson. "Applications of Recombinant Dna Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part B: Eukaryotic Gene Transcription and Post-Transcripional Rna Processing." Canadian Journal of Gastroenterology 14, no. 4 (2000): 283–92. http://dx.doi.org/10.1155/2000/385327.

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Abstract (sommario):

The transcription of DNA into RNA is the primary level at which gene expression is controlled in eukaryotic cells. Eukaryotic gene transcription involves several different RNA polymerases that interact with a host of transcription factors to initiate transcription. Genes that encode proteins are transcribed into messenger RNA (mRNA) by RNA polymerase II. Ribosomal RNAs (rRNAs) and transfer RNAs (tRNAs) are transcribed by RNA polymerase I and III, respectively. The production of each mRNA in human cells involves complex interactions of proteins (ie, trans-acting factors) with specific sequences

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Collinge, John, and David Curtis. "Decreased Hippocampal Expression of a Glutamate Receptor Gene in Schizophrenia." British Journal of Psychiatry 159, no. 6 (1991): 857–59. http://dx.doi.org/10.1192/bjp.159.6.857.

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‘A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue obtained at necropsy from 6 patients with schizophrenia, when compared to specimens from 8 controls without neurological or psychiatric signs or symptoms. These findings support suggestions of aberrant glutamatergic function in schizophrenia. Evidence that gene expression may be abnormal in schizophrenia, with decreased production of an excitatory neurotransmitter receptor, may have therapeutic as well as pathogenetic implications.’

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Harrison, Paul J., Amanda J. L. Barton, Abdolrahman Najlerahim, Brendan McDonald, and R. Carl A. Pearson. "Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease." Psychological Medicine 21, no. 4 (1991): 855–66. http://dx.doi.org/10.1017/s0033291700029858.

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SYNOPSISMessenger RNA (mRNA) is the key intermediate in the gene expression pathway. The amount of mRNA in Alzheimer's disease (AD) brains has been determined using in situ hybridization histochemistry (ISHH) to detect the poly(A) tails of polyadenylated mRNA (poly(A) + mRNA). On a regional basis, AD cases had significantly less poly(A) + mRNA than controls in hippocampus (field CA3) and cerebellum (granule cell layer). Analysis of constituent pyramidal neurons showed mean reductions per cell within AD hippocampus (field CA3) and temporal cortex, but not in visual cortex. Similar changes were

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Albitar, M., C. Peschle, and SA Liebhaber. "Theta, zeta, and epsilon globin messenger RNAs are expressed in adults." Blood 74, no. 2 (1989): 629–37. http://dx.doi.org/10.1182/blood.v74.2.629.629.

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Abstract The theta globin gene is the most recently discovered member of the alpha globin gene family. Its pattern of expression during development is not fully defined, and its encoded protein has not yet been detected in vivo. The detection of theta globin messenger RNA (mRNA) in embryonic and fetal erythroid tissue but not in adults has suggested that theta is an embryonic globin gene. The present study further defines the pattern of theta globin gene expression. We use a modification of the highly sensitive polymerase chain reaction (PCR) technique to assess the levels of theta globin gene

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Albitar, M., C. Peschle, and SA Liebhaber. "Theta, zeta, and epsilon globin messenger RNAs are expressed in adults." Blood 74, no. 2 (1989): 629–37. http://dx.doi.org/10.1182/blood.v74.2.629.bloodjournal742629.

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Abstract (sommario):

The theta globin gene is the most recently discovered member of the alpha globin gene family. Its pattern of expression during development is not fully defined, and its encoded protein has not yet been detected in vivo. The detection of theta globin messenger RNA (mRNA) in embryonic and fetal erythroid tissue but not in adults has suggested that theta is an embryonic globin gene. The present study further defines the pattern of theta globin gene expression. We use a modification of the highly sensitive polymerase chain reaction (PCR) technique to assess the levels of theta globin gene expressi

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Mikami, Maya, and Jay Yang. "Short Hairpin RNA–mediated Selective Knockdown of NaV1.8 Tetrodotoxin-resistant Voltage-gated Sodium Channel in Dorsal Root Ganglion Neurons." Anesthesiology 103, no. 4 (2005): 828–36. http://dx.doi.org/10.1097/00000542-200510000-00022.

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Background Voltage-gated sodium channels comprise a family of closely related proteins, each subserving different physiologic and pathologic functions. NaV1.8 is an isoform of voltage-gated sodium channel implicated in the pathogenesis of inflammatory and neuropathic pain, but currently, there is no isoform-specific inhibitor of any voltage-gated sodium channels. The authors explored the possibility of short hairpin RNA-mediated selective knockdown of NaV1.8 expression. Methods DNA constructs designed to transcribe short hairpin RNA targeting NaV1.8 were created and incorporated into recombina

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S, Saraswat. "RNA in Semen and Sperm: Importance and Transcriptome Analysis in Buck." Open Access Journal of Veterinary Science & Research 3, no. 2 (2018): 1–3. http://dx.doi.org/10.23880/oajvsr-16000158.

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Mammalian sperm contains an array of RNAs including messenger RNAs (mRNAs), ribosomal RNAs (rRNAs) and small RNAs (sRNAs), largely representing remnant transcripts produced during spermatogenesis. Increasing evidence has indicated that ncRNAs, which control gene expression at transcriptional, post - transcriptional, and epigenetic levels, play critical roles in male germ cell development. Sperm transcribe their RNA,RNAs have different role, high fertile buck have more RNA yie ld /spermatozoon vs low fertile buck, transcripts such as miR - 34c, BMP2, TRADD influence semen quality and fertility.

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Owens, Robert A., Kimberly B. Tech, Jonathan Y. Shao, Teruo Sano, and C. Jacyn Baker. "Global Analysis of Tomato Gene Expression During Potato spindle tuber viroid Infection Reveals a Complex Array of Changes Affecting Hormone Signaling." Molecular Plant-Microbe Interactions® 25, no. 4 (2012): 582–98. http://dx.doi.org/10.1094/mpmi-09-11-0258.

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Abstract (sommario):

Viroids like Potato spindle tuber viroid (PSTVd) are the smallest known agents of infectious disease—small, highly structured, circular RNA molecules that lack detectable messenger RNA activity, yet are able to replicate autonomously in susceptible plant species. To better understand the possible role of RNA silencing in disease induction, a combination of microarray analysis and large-scale RNA sequence analysis was used to compare changes in tomato gene expression and microRNA levels associated with PSTVd infection in two tomato cultivars plus a third transformed line expressing small PSTVd

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Rodrigues, Daniela F., Vera M. Costa, Ricardo Silvestre, Maria L. Bastos, and Félix Carvalho. "Methods for the analysis of transcriptome dynamics." Toxicology Research 8, no. 5 (2019): 597–612. http://dx.doi.org/10.1039/c9tx00088g.

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Abstract The transcriptome is the complete set of transcripts in a cell or tissue and includes ribosomal RNA (rRNA), messenger RNA (mRNA), transfer RNA (tRNA), and regulatory noncoding RNA. At steady-state, the transcriptome results from a compensatory variation of the transcription and decay rate to maintain the RNA concentration constant. RNA transcription constitutes the first stage in gene expression, and thus is a major and primary mode of gene expression control. Nevertheless, regulation of RNA decay is also a key factor in gene expression control, involving either selective RNA stabiliz

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Bollmann, Stephanie, Dengpan Bu, Jiaqi Wang, and Massimo Bionaz. "Unmasking Upstream Gene Expression Regulators with miRNA-corrected mRNA Data." Bioinformatics and Biology Insights 9S4 (January 2015): BBI.S29332. http://dx.doi.org/10.4137/bbi.s29332.

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Abstract (sommario):

Expressed micro-RNA (miRNA) affects messenger RNA (mRNA) abundance, hindering the accuracy of upstream regulator analysis. Our objective was to provide an algorithm to correct such bias. Large mRNA and miRNA analyses were performed on RNA extracted from bovine liver and mammary tissue. Using four levels of target scores from TargetScan (all miRNA:mRNA target gene pairs or only the top 25%, 50%, or 75%) Using four levels of target scores from TargetScan (all miRNA:mRNA target gene pairs or only the top 25%, 50%, or 75%) and four levels of the magnitude of miRNA effect (ME) on mRNA expression (3

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Liu, Xiaoyi, Liying Liu, Maozhi Zhang, et al. "Messenger RNA expression of chicken CLOCK gene in the response to Campylobacter jejuni inoculation." Poultry Science 94, no. 9 (2015): 2124–30. http://dx.doi.org/10.3382/ps/pev203.

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43

Iwasa, Atushi, Hiroshi Higuchi, and Hiroshi Yoshida. "Age-related changes in messenger RNA expression of rat neuropeptide Y (NPY) precursor gene." Japanese Journal of Pharmacology 49 (1989): 206. http://dx.doi.org/10.1016/s0021-5198(19)56455-1.

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Fraser, Melissa M., Patricia M. Watson, Mostafa M. Fraig, et al. "CaSm-Mediated Cellular Transformation Is Associated with Altered Gene Expression and Messenger RNA Stability." Cancer Research 65, no. 14 (2005): 6228–36. http://dx.doi.org/10.1158/0008-5472.can-05-0650.

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45

Johnston, Sean, Jar-How Lee, and Dan S. Ray. "High-level expression of M13 gene II protein from an inducible polycistronic messenger RNA." Gene 34, no. 2-3 (1985): 137–45. http://dx.doi.org/10.1016/0378-1119(85)90121-0.

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46

Zhang, Aiguo, Larry Pastor, Quan Nguyen, et al. "Small Interfering RNA and Gene Expression Analysis Using a Multiplex Branched DNA Assay without RNA Purification." Journal of Biomolecular Screening 10, no. 6 (2005): 549–56. http://dx.doi.org/10.1177/1087057105277414.

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Abstract (sommario):

The authors have developed a novel multiplex detection system that quantitatively measures the expression level of 11 messenger RNAs (mRNAs) directly from cell lysates or tissue homogenates without RNA purification. The system incorporates branched DNA (bDNA) technology from Bayer and a multiplex bead array platform from Luminex. In this study, a 21-nt synthetic small interfering RNA (siRNA; specifically designed to knockdown interleukin-8 [IL-8] expression) was delivered into HeLa cells. Using the multiplex bDNA assay, gene expression levels were measured simultaneously from cell lysates for

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47

Chapman, Ria M., Caroline L. Tinsley, Matthew J. Hill, et al. "Convergent Evidence That ZNF804A Is a Regulator of Pre-messenger RNA Processing and Gene Expression." Schizophrenia Bulletin 45, no. 6 (2018): 1267–78. http://dx.doi.org/10.1093/schbul/sby183.

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Abstract (sommario):

Abstract Genome-wide association studies have linked common variation in ZNF804A with an increased risk of schizophrenia. However, little is known about the biology of ZNF804A and its role in schizophrenia. Here, we investigate the function of ZNF804A using a variety of complementary molecular techniques. We show that ZNF804A is a nuclear protein that interacts with neuronal RNA splicing factors and RNA-binding proteins including RBFOX1, which is also associated with schizophrenia, CELF3/4, components of the ubiquitin-proteasome system and the ZNF804A paralog, GPATCH8. GPATCH8 also interacts w

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Aleyakpo, Benjamin, Oghenetega Umukoro, Ryan Kavlie та ін. "G-protein αq gene expression plays a role in alcohol tolerance in Drosophila melanogaster". Brain and Neuroscience Advances 3 (січень 2019): 239821281988308. http://dx.doi.org/10.1177/2398212819883081.

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Abstract (sommario):

Ethanol is a psychoactive substance causing both short- and long-term behavioural changes in humans and animal models. We have used the fruit fly Drosophila melanogaster to investigate the effect of ethanol exposure on the expression of the Gαq protein subunit. Repetitive exposure to ethanol causes a reduction in sensitivity (tolerance) to ethanol, which we have measured as the time for 50% of a set of flies to become sedated after exposure to ethanol (ST50). We demonstrate that the same treatment that induces an increase in ST50 over consecutive days (tolerance) also causes a decrease in Gαq

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Guan, Guofang, Ranwei Li, Wenfang Tang, et al. "Expression of RNA-binding motif 10 is associated with advanced tumor stage and malignant behaviors of lung adenocarcinoma cancer cells." Tumor Biology 39, no. 3 (2017): 101042831769174. http://dx.doi.org/10.1177/1010428317691740.

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Abstract (sommario):

This study assessed RNA-binding motif 10 expression in lung adenocarcinoma tissues and examined the role and mechanism of RNA-binding motif 10 in the regulation of lung adenocarcinoma malignancy. Lung adenocarcinoma and corresponding adjacent non-tumor lung tissues from 41 patients were subjected to reverse transcription-polymerase chain reaction and Western blot assessment to detect RNA-binding motif 10 expression. Recombinant lentivirus carrying RNA-binding motif 10 complementary DNA was used to infect lung adenocarcinoma cell lines, A549 and H1299 cells. Complementary DNA microarray was use

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50

Blum and Moradpour. "Recombinant drugs and gene therapy." Therapeutische Umschau 56, no. 12 (1999): 730–37. http://dx.doi.org/10.1024/0040-5930.56.12.730.

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Abstract (sommario):

Ausgehend von der Biologie somatischer Zellen mit Transkription der chromosomalen DNA in messenger RNA (mRNA) und deren Translation in Proteine werden die Prinzipien der Gentechnologie illustriert. Die Gentechnologie ermöglicht die Klonierung, Identifizierung und Charakterisierung von Genen sowie deren Expression mit Synthese von medizinisch relevanten Proteinen. Die Produkte der Gentechnologie sind somit zum einen klonierte Gene, die für die molekulare Diagnostik und die Gentherapie medizinisch bedeutsam sind. Zum anderen sind es in vitro oder in vivo hergestellte Proteine, die als Diagnostik

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